WO2012164137A1 - Cellules mères et cellules de la souche neurale dérivées de la glie olfactive enveloppante, et leurs applications - Google Patents

Cellules mères et cellules de la souche neurale dérivées de la glie olfactive enveloppante, et leurs applications Download PDF

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Publication number
WO2012164137A1
WO2012164137A1 PCT/ES2012/070404 ES2012070404W WO2012164137A1 WO 2012164137 A1 WO2012164137 A1 WO 2012164137A1 ES 2012070404 W ES2012070404 W ES 2012070404W WO 2012164137 A1 WO2012164137 A1 WO 2012164137A1
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cells
stem cells
neural
glia
olfactory
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PCT/ES2012/070404
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English (en)
Spanish (es)
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Cintia MUÑOZ QUILES
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Fundación Investigación En Regeneración Del Sistema Nervioso
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system

Abstract

La présente invention concerne l'obtention de cellules mères et de cellules de souche neurale (neurones, glie, autres) à partir de la glie olfactive enveloppante (OEG ou GEO, aussi appelées cellules olfactives enveloppantes ou OEC), les cellules ainsi obtenues et leurs applications. Plus concrètement, l'invention concerne des cellules mères et les précurseurs de souche neurale (ou autres) dérivés de la dédifférenciation cellulaire de la glie olfactive enveloppante, qui peuvent être différenciés et donner lieu à divers types cellulaires, généralement de la souche neurale, sans être exclusifs. L'invention concerne également l'application des cellules mères et des différentes lignées cellulaires obtenues à partir de la glie olfactive enveloppante, et les produits dérivés de tous les types cellulaires générés, dans le traitement de maladies, en thérapie cellulaire, dans la recherche et la conception de nouveaux médicaments et dans des études cellulaires, moléculaires et de génomique et pharmacogénomique de pathologies humaines.
PCT/ES2012/070404 2011-05-30 2012-05-30 Cellules mères et cellules de la souche neurale dérivées de la glie olfactive enveloppante, et leurs applications WO2012164137A1 (fr)

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ES201100630 2011-05-30
ESP201100630 2011-05-30

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105349491A (zh) * 2015-12-15 2016-02-24 黄红云 来源于嗅粘膜神经元细胞分离制备技术
US11959100B2 (en) 2017-11-30 2024-04-16 Kyoto University Method for culture of cells

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105349491A (zh) * 2015-12-15 2016-02-24 黄红云 来源于嗅粘膜神经元细胞分离制备技术
CN105349491B (zh) * 2015-12-15 2019-09-24 北京市虹天济神经科学研究院 来源于嗅粘膜神经元细胞分离制备技术
US11959100B2 (en) 2017-11-30 2024-04-16 Kyoto University Method for culture of cells

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