WO2012158772A1 - Genetic identification of domestic cat breeds and populations - Google Patents

Genetic identification of domestic cat breeds and populations Download PDF

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Publication number
WO2012158772A1
WO2012158772A1 PCT/US2012/038101 US2012038101W WO2012158772A1 WO 2012158772 A1 WO2012158772 A1 WO 2012158772A1 US 2012038101 W US2012038101 W US 2012038101W WO 2012158772 A1 WO2012158772 A1 WO 2012158772A1
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Prior art keywords
phen
feline
markers
populations
population
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PCT/US2012/038101
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French (fr)
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Leslie A. Lyons
Jennifer D. KURUSHIMA
Lutz FROENICKE
Monika J. LIPINSKI
Barbara GANDOLFI
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The Regents Of The University Of California
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Publication of WO2012158772A1 publication Critical patent/WO2012158772A1/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Definitions

  • the invention relates to determining the contribution of one or more feline populations to the genome of a feline using a predetermined set of genetic markers, including single nucleotide polymorphisms (SNPs), short tandem repeats (STRs) and DNA- based phenotypic markers.
  • SNPs single nucleotide polymorphisms
  • STRs short tandem repeats
  • DNA- based phenotypic markers including single nucleotide polymorphisms (SNPs), short tandem repeats (STRs) and DNA- based phenotypic markers.
  • CR mtDNA control region
  • the present invention demonstrates the utility of a panel of 148 evenly dispersed genome-wide SNPs for population assignment of cats. Different assignment techniques are examined and demonstrated in a species exhibiting many recent and extreme population bottlenecks, comparing the power and efficiency of this 148 SNP panel to 4-fold fewer microsatellites. The power of phenotypic DNA variants is demonstrated for sensitivity and specificity to support individual assignment, specifically for closely related cat breeds that are demarcated by single gene traits.
  • the present invention provides genetic markers useful for the determination of the the population of origin (e.g., ancestral lineage and/or contributing breed(s)) of a test feline. Accordingly, in one aspect, the invention provides computer implemented methods for determining the contributions of feline populations to a feline genome. In some embodiments, the methods comprise:
  • the invention provides methods for defining one or more feline populations.
  • the methods comprise:
  • the invention provides methods for determining the contributions of feline populations to a feline genome.
  • the methods comprise performing a genotyping assay on a sample comprising genomic DNA obtained from a test feline to determine the identity of one or both alleles present in the test feline genome for each marker of a set of markers, wherein the set of markers is indicative of the contribution of feline populations to the genome of the test feline, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1.
  • the invention provides methods of assigning a feline individual to a population of origin (e.g., an ancestral lineage and/or one or more contributing breeds), which comprises:
  • step (c) assigning the feline individual to the one or more most likely populations identified in step (b).
  • the individual is assigned to the one or more most likely feline populations if the population genotype probability for the most likely feline populations exceeds the value of assignment to any other feline populations of the database.
  • SNPs comprises at least about 5 SNPs listed in Table 1, for example, at least about 10, 15, 20, 25, 30, 40, 50, 60, 70, 75, 80, 90, 100, 110, 120, 125, 130, 140 or 148 SNPs listed in Table 1.
  • the SNPs listed in Table 1 are as depicted at position 61 of a polynucleotide selected from the group consisting of SEQ ID NO: l to SEQ ID NO: 148 listed in Table 1.
  • the plurality of SNPs comprises all 148 SNPs listed in Table 1, e.g., as depicted at position 61 of polynucleotides SEQ ID NO: l to SEQ ID NO: 148 listed in Table 1.
  • the plurality of SNPs listed in Table 1 are as depicted at position 61 of a polynucleotide selected from the group consisting of SEQ ID NO: l to SEQ ID NO: 148.
  • the set of markers comprises a plurality of SNPs, wherein the SNPs are selected from the group consisting of position 61 of SEQ ID NO: l, position 61 of SEQ ID NO:2, position 61 of SEQ ID NO:3, position 61 of SEQ ID NO:4, position 61 of SEQ ID NO:5, position 61 of SEQ ID NO:6, position 61 of SEQ ID NO:7, position 61 of SEQ ID NO:8, position 61 of SEQ ID NO:9, position 61 of SEQ ID NO:10, position 61 of SEQ ID NO: 11, position 61 of SEQ ID NO: 12, position 61 of SEQ ID
  • the set of markers comprises a plurality of SNPs, wherein the SNPs are selected from the group consisting of chrAl_10141047,
  • chrB3_l 04483970 chrB3_l 11000326, chrB3_l 3666494, chrB3_39203469, chrB3_51317931, chrB3_57141954, chrB3_77094074, chrB4_l 05706694, chrB4_142658074, chrB4_143006494, chrB4_144693308, chrB4_146486983,
  • chrB4_21098349 chrB4_255106, chrB4_3093827, chrB4_40319102, chrB4_47638578, chrCl_l 16355295, chrCl_123164748, chrCl_l 81852965, chrCl_190502133,
  • chrCl_34981315 chrCl_396397, chrCl_44520932, chrCl_52456776, chrC2_106991233, chrC2_147124460, chrC2_l 50774106, chrC2_156491175, chrC2_187325, chrC2_262401, chrC2_5215469, chrDl_101321498, chrD 1 104941557, chrD 1 105498119,
  • the set of markers further comprises one or more microsatellite markers.
  • the set of markers further comprises one or more STRs selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
  • a most likely population of origin is based on one or more morphological features of the test feline.
  • one or more morphological features of the test feline allow the exclusion of one or more of the candidate populations of origin.
  • the feline may be evaluated for coat color (e.g. , chocolate, cinnamon, dilute, orange, white), coat patterning (e.g., agouti, tabby, spotted, ticked, calico, point coloring), coat texture (e.g., straight or rex), coat length (e.g., hairless, short or long), ear morphology (e.g. , normal, curled or folded), paw morphology (e.g. , normal or polydactyl), and tail morphology (e.g., manx, bobtail, long).
  • coat color e.g. , chocolate, cinnamon, dilute, orange, white
  • coat patterning e.g., agouti, tabby, spotted, ticked, calico, point coloring
  • the set of markers further comprises one or more phenotypic markers.
  • the set of markers further comprises one or more of the phenotypic markers selected from the group consisting of Phen CM AH G 139 A, Phen ASIP del, Phen_MLPH_T83del, Phen_MClR_G250A, Phen_TYRPl_C298T, Phen_TYRPl_5IVS6, Phen_TYR_del975C, Phen_TYR_G715T, Phen_TYR_G940A, Phen_KIT_G1035C_BI, Phen_FGF5_475, Phen_FGF5_474, phen_FGF5_406, Phen_FGF5_356, Phen_GBLl_G1457C_SIA_KOR,
  • Phen_MYBPC_C2460T_RAG Phen MPO ALC
  • Phen PLAU AG ALC
  • Phen CMAH del Phen_HEXB_C667T_DSH, Phen_GM2A_Del_DSH,
  • Phen lDUA del DSH Phen_ARSB_G1558A_SIA, Phen_ARSB_T1427C_Sia,
  • the set of markers further comprises one or more of the phenotypic markers selected from the group consisting of SEQ ID NO: 149 to SEQ ID NO:202, shown in Table 3.
  • the marker locus genotypes for each candidate population are in Hardy- Weinberg Equilibrium and/or Gametic Phase Equilibrium.
  • the genotype information in each feline population profile comprises identities of one or both alleles of each marker of the set of markers. In some embodiments, the genotype information in each feline population profile comprises allele frequencies for one or both alleles of each marker of the set of markers. In various embodiments, the genotype information in each feline population profile comprises both the identities and the allele frequencies of one or both alleles of each marker of the set of markers.
  • the database of feline population profiles comprises one or more feline population profiles.
  • the database of feline population profiles comprises a plurality of feline population profiles, for example, between about 5 and about 500 feline population profiles, for example, about 10-400, 15-300, or 20-200 feline population profiles, for example, about 5, 10, 15, 20, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, or more, feline population profiles.
  • the database of feline populations profiles comprise one or more profiles of feline ancestral lineages, i.e., randombred populations of origin.
  • the feline populations profiles may comprise the profiles of one or more ancestral lineages of random bred worldwide populations of cats, including, e.g., Europe,
  • the feline populations profiles may comprise the profiles of 1, 2, 3, 4, 5, 6, 7, 8, or more, ancestral lineages of random bred worldwide populations of cats.
  • the database of feline populations profiles comprise profiles of one or more feline breeds. Breeds of interest are recognized by at least one cat breed registry.
  • the breed may be recognized by one or more cat registries selected from the group consisting of The International Cat Association (TICA); the Cat Fanciers' Association (CFA); The Australian Cat Federation (ACF); Co-Ordinating Cat Council of Australia (CCC of A); Federation Internationale Feline (FIFe); Governing Council of the Cat Fancy (GCCF); The New Zealand Cat Fancy (NZCF); The Southern African Cat Council (SACC); The World Cat Federation (WCF); American Cat Fanciers Association (ACFA); The Traditional Cat Association, Inc. (TCA); International
  • IPCBA International Cat Breeders' Alliance
  • CCA Canadian Cat Association
  • CFF Cat Fanciers' Federation
  • AACE American Association of Cat Enthusiasts
  • WNCA Australian National Cats
  • CCI Catz Incorporated
  • CCIQ Council of Federated Cat Clubs of Qld
  • GCCFSA The Feline Association of NSW
  • FCC Feline Control Council
  • SW CFA The Governing Council of the Cat Fancy of South Australia
  • the database comprises profiles of a plurality of feline breeds, for example, profiles of at least about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more, feline breeds recognized by one or more cat registries.
  • the profiles of feline breeds are selected from the group consisting of Persian, Exotic Shorthair (SH), British SH, Scottish Fold, Chartreux, American SH, Sphynx, Japanese Bobtail, Cornish Rex, Ragdoll, Maine Coon, Abyssinian, Siberian, Norwegian FC, Manx, Egyptian Mau, Turkish Angora, Turkish Van, Bengal, Sokoke, Ocicat, Russian Blue, Australian Mist, Burmese, Birman, Havana Brown, Korat, Siamese and Singapura.
  • SH Exotic Shorthair
  • British SH British Fold
  • Chartreux American SH
  • Sphynx Japanese Bobtail
  • Cornish Rex Ragdoll
  • Maine Coon Abyssinian
  • Siberian Norwegian FC
  • Manx Egyptian Mau
  • Turkish Angora Turkish Van
  • Bengal Sokoke
  • Ocicat Russian Blue
  • Australian Mist Burmese
  • Birman Havana Brown
  • Korat Siamese and Singapura
  • the profiles of feline breeds are selected from the group consisting of Abyssinian, American Bobtail, American Bobtail Shorthair (SH), American Curl, American Curl Longhair (LH), American Shorthair, American Wirehair, Balinese, Bengal, Birman, Bombay, British Shorthair, British Longhair, Burmese, Chartreux, Colorpoint Shorthair, Cornish Rex, Cymric, Devon Rex, Don-Skoy, Egyptian Mau, European Burmese, Exotic Shorthair, Havana Brown, Himalayan, Japanese Bobtail, Japanese Bobtail Longhair, Korat, LaPerm, Maine Coon, Manx, Munchkin, Munchkin Longhair, Nebelung, Norwegian Forest Cat, Ocicat, Oriental Longhair, Oriental Shorthair, Persian, Peterbald, Pixiebob, Pixiebob Longhair, RagaMuffm, Ragdoll, Russian Blue, Scottish Fold, Scottish Fold Longhair, Selkirk Rex, Selkirk Rex Longhair, Siamese, Siberian, Singapur
  • the test feline is suspected of having genetic contributions of 4 or fewer breeds.
  • a test feline may be suspected of being a purebred, having a genetic composition primarily contributed from a single breed, having a genetic composition primarily contributed by two distinct breeds, having a genetic composition primarily contributed by three distinct breeds, or having a genetic composition primarily contributed by four distinct breeds.
  • the set of markers comprises a subset of the 148 SNP markers listed in Table 1 and the method determines the contributions of one or more feline populations to the test feline genome. In various embodiments, the set of markers comprises fewer than about 150 SNP markers and the method determines the contributions of 1, 2, 3 or 4 feline populations to the test feline genome.
  • the identity of one or both alleles of a marker can be determined using any method in the art. In some embodiments, the identity of one or both alleles of a marker is determined by amplifying genomic DNA of the test feline using primers specific for each of the set of markers and determining the size of the amplification product. In some embodiments, the identity of one or both alleles of a marker is determined by amplifying genomic DNA of the test feline using primers specific for each of the set of markers and sequencing the amplification product.
  • the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises a genotype clustering program. In some embodiments, the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises an assignment program. In some embodiments, the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises both a genotype clustering program and an assignment program.
  • the clustering program is a Bayesian clustering program.
  • the assignment program is a likelihood or frequentist program.
  • the test feline is assigned to the most likely population of origin if the population genotype probability for the most likely population of origin exceeds the value of assignment to any other population of the database.
  • the contributions of two or more genetically related feline populations to the test feline genome are discriminated by comparing the alleles in the test feline genome to a database comprising profiles of the two or more genetically related feline populations.
  • the two or more genetically related feline populations being discriminated are selected from the group consisting of (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese; (iv) Singapura and Burmese; (v) Birman and Korat, and (vi) Siamese and Havana Brown.
  • one or more phenotypic markers can be determined, in addition to determining the identity of a plurality of the SNPs listed in Table 1 , to help distinguish between the contributions of two or more genetically related feline populations to the test feline genome.
  • the genotype of the FGF5 SNP which causes long hair, can be determined to affirmatively assign a test feline to one or more breeds selected from the group consisting of Persian, Maine Coon, Turkish Angora, Vietnamese Van and Birman.
  • a FGF5 genotype indicative of the presence of long hair can be used to exclude assignment to one or more breeds selected from the group consisting of Abyssinian, Egyptian Mau, Sokoke, Ocicat, and short-haired varieties of other recognized feline breeds.
  • the genotypes of one or both alleles of one or more of the FGF5 SNPs depicted by SEQ ID NOs: 159-162 are determined.
  • the genotypes of one or both alleles of all four of the FGF5 SNPs depicted by SEQ ID NOs: 159-162 are determined.
  • the methods further comprise reporting the results of the analysis.
  • the methods further comprise the step of providing a document displaying the contributions of one or more feline populations to the genome of the test feline genome.
  • the document provides additional information regarding the one or more feline populations that contributed to the genome of the test feline.
  • the document provides health-related information.
  • the document provides a certification of the contributions of one or more feline populations to the genome of the test feline.
  • the document provides a representation of the one or more feline populations that contributed to the genome of the test feline.
  • the invention provides one or more primer sets for determining the identity of one or both alleles a plurality of single nucleotide
  • primer sets for determining the identity of one or both alleles of at least about 5 SNPs for example, at least about 10, 15, 20, 25, 30, 40, 50, 60, 70, 75, 80, 90, 100, 110, 120, 125, 130, 140, 148 SNPs listed in Table 1 are provided.
  • the primer sets may be provided in a kit.
  • the invention provides one or more computer-readable media.
  • the computer-readable media comprise:
  • a data structure stored thereon for use in distinguishing feline populations comprising: (i) marker data, wherein the marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
  • genotype information data provides genotype information for each marker of a set of markers in a feline population, wherein a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile;
  • each feline population profile comprises genotype information for the set of markers in the feline population.
  • the invention provides one or more computer-readable media comprising a data structure stored thereon for use in distinguishing feline
  • the data structure comprises:
  • marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ;
  • genotype information data provides genotype information for each marker of a set of markers in a feline population
  • a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile.
  • isolated refers to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. Genomic DNA or a polynucleotide that is the predominant species present in a preparation is substantially purified.
  • purified denotes that a nucleic acid gives rise to essentially one band in an electrophoretic gel. Particularly, it means that the nucleic acid or genomic DNA is at least 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure.
  • nucleic acid and “polynucleotide” are used interchangeably herein to refer to deoxyribonucleotides or ribonucleotides and polymers thereof in either single- or double-stranded form.
  • the term encompasses nucleic acids containing known nucleotide analogs or modified backbone residues or linkages, which are synthetic, naturally occurring, and non-naturally occurring, which have similar binding properties as the reference nucleic acid, and which are metabolized in a manner similar to the reference nucleotides.
  • nucleic acid sequence also encompasses conservatively modified variants thereof (e.g., degenerate codon substitutions) and complementary sequences, as well as the sequence explicitly indicated.
  • degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is substituted with mixed-base and/or deoxyinosine residues (Batzer et al, Nucleic Acid Res.
  • nucleic acid is used interchangeably with gene, cDNA, mRNA, oligonucleotide, and polynucleotide.
  • nucleic acid sequences refer to two or more sequences or subsequences that are the same or have a specified percentage of nucleotides that are the same (e.g., 80% identity, preferably 85%, 90%, 95%, 96%, 97%, 98%, 99% identity over a specified region such as the nucleic acid sequences of SEQ ID NOs: 1-148 and SEQ ID NOs: 149-202), when compared and aligned for maximum correspondence over a comparison window, or designated region as measured using a known sequence comparison algorithm (e.g. , BLAST, ALIGN) set to default settings or by manual alignment and visual inspection.
  • a known sequence comparison algorithm e.g. , BLAST, ALIGN
  • sequences are then said to be “substantially identical.”
  • This definition also refers to the complement of a test sequence.
  • the identity exists over a region that is at least about 25 nucleotides in length, or more preferably over a region that is 50-100 nucleotides in length, or over the full length of the contextual sequence flanking the genetic marker.
  • a “label” or “detectable label” is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, or chemical means. For example, useful
  • radioisotopes e.g., H, S, P, Cr, or I
  • fluorescent dyes e.g., H, S, P, Cr, or I
  • electron-dense reagents e.g., enzymes (e.g., alkaline phosphatase, horseradish peroxidase, or others commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins for which antisera or monoclonal antibodies are available (e.g., the polypeptide comprising a sequence encoded by SEQ ID NO: l can be made detectable, e.g., by incorporating a radiolabel into the peptide, and used to detect antibodies specifically reactive with the peptide).
  • radioisotopes e.g., H, S, P, Cr, or I
  • enzymes e.g., alkaline phosphatase, horseradish peroxidase, or others commonly used in an ELISA
  • biotin
  • An "amplification reaction” refers to any chemical reaction, including an enzymatic reaction, which results in increased copies of a template nucleic acid sequence.
  • Amplification reactions include polymerase chain reaction (PCR) and ligase chain reaction (LCR) (see U.S. Pat. Nos. 4,683,195 and 4,683,202; PCR Protocols: A Guide to Methods and Applications (Innis et al, eds, 1990)), strand displacement amplification (SDA) (Walker, et al. Nucleic Acids Res. 20(7): 1691 (1992); Walker PCR Methods Appl 3(1): 1 (1993)), transcription-mediated amplification (Phyffer, et al., J. Clin. Microbiol.
  • “Amplifying” refers to submitting a solution to conditions sufficient to allow for amplification of a polynucleotide if all of the components of the reaction are intact.
  • Components of an amplification reaction include, e.g., primers, a polynucleotide template, polymerase, nucleotides, and the like.
  • primers e.g., a polynucleotide template, polymerase, nucleotides, and the like.
  • an amplifying step can occur without producing a product if, for example, primers are degraded.
  • Amplification reagents refer to reagents used in an amplification reaction. These reagents can include, e.g., oligonucleotide primers; borate, phosphate, carbonate, barbital, Tris, etc. based buffers (see, U.S. Pat. No. 5,508, 178); salts such as potassium or sodium chloride; magnesium; deoxynucleotide triphosphates (dNTPs); a nucleic acid polymerase such as Taq DNA polymerase; as well as DMSO; and stabilizing agents such as gelatin, bovine serum albumin, and non-ionic detergents (e.g. Tween-20).
  • a "plurality" refers to two or more, for example, 2, 3, 4, 5, 10, 15, 20, 25, 30,
  • a plurality refers to concurrent or sequential determination of about 2-150, 5-148, 50-148, 100-148 markers, for example, about 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 1 10, 120, 130, 140, 145, 148, 150, or more, markers.
  • "plurality" refers to all markers listed in one or more tables, e.g., all markers listed in Table 1 , and optionally also including all markers listed in Table 3.
  • a "single nucleotide polymorphism" or "SNP” refers to polynucleotide that differs from another polynucleotide by a single nucleotide exchange. For example, without limitation, exchanging one A for one C, G or T in the entire sequence of polynucleotide constitutes a SNP. Of course, it is possible to have more than one SNP in a particular polynucleotide. For example, at one locus in a polynucleotide, a C may be exchanged for a T, at another locus a G may be exchanged for an A and so on.
  • a “variant” is a difference in the nucleotide sequence among related polynucleotides. The difference may be the deletion of one or more nucleotides from the sequence of one polynucleotide compared to the sequence of a related polynucleotide, the addition of one or more nucleotides or the substitution of one nucleotide for another.
  • the terms "mutation,” “polymorphism” and “variant” are used interchangeably herein to describe such variants.
  • variable in the singular is to be construed to include multiple variances; i. e., two or more nucleotide additions, deletions and/or substitutions in the same polynucleotide.
  • a "point mutation” refers to a single substitution of one nucleotide for another.
  • a nucleic acid "that distinguishes" as used herein refers to a
  • polynucleotide(s) that distinguishes a first polymorphism (e.g., a major allele of a SNP) from a second polymorphism (e.g. , a minor allele of the same SNP) at the same position in the genomic sequence.
  • the nucleic acid that distinguishes can allow for polynucleotide extension and amplification after annealing to a polynucleotide comprising the first polymorphism, but will not allow for polynucleotide extension or amplification after annealing to a polynucleotide comprising the second polymorphism.
  • a nucleic acid that distinguishes a first polymorphism from a second polymorphism at the same position in the sequence will hybridize to a polynucleotide comprising the first polymorphism but will not hybridize to a polynucleotide comprising the second
  • the invention provides polynucleotides that distinguish the SNPs and genetic markers listed in Table 1.
  • primer refers to a nucleic acid sequence that primes the synthesis of a polynucleotide in an amplification reaction.
  • a primer comprises fewer than about 100 nucleotides and preferably comprises fewer than about 30 nucleotides.
  • Exemplary primers range from about 5 to about 25 nucleotides.
  • the "integrity" of a primer refers to the ability of the primer to primer an amplification reaction. For example, the integrity of a primer is typically no longer intact after degradation of the primer sequences such as by endonuclease cleavage.
  • sequence refers to a sequence of nucleotides that are contiguous within a second sequence but does not include all of the nucleotides of the second sequence.
  • a “target” or “target sequence” refers to a single or double stranded polynucleotide sequence sought to be amplified in an amplification reaction. Two target sequences are different if they comprise non-identical polynucleotide sequences.
  • nucleic acid probe or oligonucleotide is defined as a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation.
  • a probe may include natural (i.e., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.).
  • the bases in a probe may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization.
  • probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.
  • probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions.
  • the probes are preferably directly labeled as with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled such as with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence.
  • a "labeled nucleic acid probe or oligonucleotide” is one that is bound, either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe.
  • Bio sample as used herein is a sample of biological tissue or fluid that contains genomic DNA. These samples can be tested by the methods described herein and include body fluids such as whole blood, serum, plasma, cerebrospinal fluid, urine, lymph fluids, and various external secretions of the respiratory, intestinal and genitourinary tracts, tears, saliva, milk, white blood cells, myelomas, and the like; and biological fluids such as cell extracts, cell culture supernatants; fixed tissue specimens; and fixed cell specimens. Biological samples may also include sections of tissues such as biopsy and autopsy samples or frozen sections taken for histologic purposes. A biological sample can also be skin cells, a cheek swab or a hair bulb sample. These samples are well known in the art. A biological sample is obtained from any mammal including, e.g., a cat. A biological sample may be suspended or dissolved in liquid materials such as buffers, extractants, solvents and the like.
  • feline refers to an animal that is a member of the family Felidae; including without limitation the subfamilies, Felinae, Pantherinae, and Acinonychinae; the genera Caracal, Catopuma, Felis, Herpailurus, Leopardus, Leptailurus, Lynx, Oncifelis, Oreailurus, Otocolobus, Prionailurus, Profelis, Puma, Neofelis, Panthera, Pardofelis, and Uncia; the species felis, lybica, jubatus, caracal, badia, bieti, chaus, margarita, nigripes, silvestris, gordonii, yaguarondi, pardalis, tigrinus, wiedi, serval, canadensis, lynx, pardinus, rufus, colocolo, geoffroyi, guigna, jacobita
  • determining the contributions of feline populations refers to estimating or inferring using statistical methods the contributions of feline populations to draw conclusions regarding whether one or more feline populations contributed to the genome of a test feline.
  • feline population refers to a group of felines related by descent, such as a domestic cat breed.
  • the term "breed” refers to an intraspecies group of animals with relatively uniform phenotypic traits that have been selected for under controlled conditions by man. For example, The International Cat Association (TICA) recognizes 57 Championship
  • the Cat Fanciers' Association lists 40 breeds.
  • the methods of the invention may be used to estimate the genetic contributions of any cat breed, including, but not limited to Abyssinian, American Bobtail, American Bobtail Shorthair (SH), American Curl, American Curl Longhair (LH), American Shorthair, American Wirehair, Balinese, Bengal, Birman, Bombay, British Shorthair, British Longhair, Burmese, Chartreux, Colorpoint Shorthair, Cornish Rex, Cymric, Devon Rex, Egyptian Mau, European Burmese, Exotic Shorthair, Havana Brown, Himalayan, Japanese Bobtail, Japanese Bobtail Longhair, Korat, LaPerm, Maine Coon, Manx, Munchkin, Munchkin Longhair, Nebelung, Norwegian Forest Cat, Ocicat, Oriental Longhair, Oriental Shorthair, Persian, Peterbald, Pixiebob, Pixiebob Longhair, RagaMuffm, Ragdoll
  • the term "marker” refers to any polymorphic genomic locus that is sufficiently informative across the feline populations used in the methods of the invention to be useful for estimating the genetic contribution of these feline populations to the genome of a test feline.
  • a genomic locus is polymorphic if it has at least two alleles.
  • allele refers to a particular form of a genomic locus that may be distinguished from other forms of the genomic locus by its nucleic acid sequence. Thus, different alleles of a genomic locus represent alternative nucleic acid sequences at that locus.
  • any individual feline genome there are two alleles for each marker. If both alleles are the same, the genome is homozygous for that marker. Conversely, if the two alleles differ, the genome is heterozygous for that marker.
  • Population-specific alleles are alleles that are present at some frequency in one feline population but have not been observed in the sampled feline from comparison feline populations (although they may be present at a significantly lower frequency).
  • Population-specific alleles may be used to assign an individual to a particular population. Accordingly, the difference in allele frequencies between populations can be used for determining genetic contributions.
  • a "set of markers” refers to a minimum number of markers that are sufficient for determining the genetic contribution of the feline populations used in the methods of the invention to the genome of a test feline.
  • the minimum number of markers required depends on the informativeness of the markers for the particular feline populations that are being used, as further described below.
  • the set of markers may comprise at least about 5, 10, 25, 50, 75, 100, 125, 150 markers, or more, as appropriate.
  • a "feline population profile" as used herein refers to the collection of genotype information for the set of markers in a feline population.
  • a feline population profile may comprise genotype information for most or all alleles of most or all markers in the set of markers in the feline population.
  • An "allele frequency” refers to the rate of occurrence of an allele in a population. Allele frequencies are typically estimated by direct counting. Generally, allele frequencies in a feline population are estimated by obtaining the identity of one or both alleles for each of the set of markers in at least about five members of that feline population.
  • a “database of feline population profiles” refers to the collection of feline population profiles for all of the feline populations used in an exemplary method of the invention.
  • the database of feline population profiles comprises between about five and about 500 feline population profiles, such as about 20 feline population profiles, about 50 feline population profiles, or about 100 feline population profiles.
  • a "computer-readable medium” refers to any available medium that can be accessed by computer and includes both volatile and nonvolatile media, removable and nonremovable media.
  • modulated data signal means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal.
  • a "data structure” refers to a conceptual arrangement of data and is typically characterized by rows and columns, with data occupying or potentially occupying each cell formed by a row-column intersection.
  • Figure 1 illustrates a map of random bred cat sampling locations.
  • the pie charts represent the percentage of the eight worldwide lineages found at each location.
  • the shading indicates the strength of the predominating lineage for each region of the world.
  • Figures 2A-F illustrate Delta K plots of random bred cat population structuring. Graphs of both the mean Ln(K) and ⁇ calculations based on the results of Bayesian clustering. Top) SNPs only, Middle) STRs only, Bottom) SNPs and STRs combined. Points where a peaks in a ⁇ plot occur indicate population stratification with higher likelihood than those where valleys occur.
  • Figures 5A-B illustrate principal coordinate analysis of world cat populations.
  • Figures 6A-B illustrate neighbor-joining trees of world cat populations.
  • Branch colors indicate the population as assigned by STRUCTURE.
  • Figures 7A-D illustrate log likelikhood and Delta K plots from the Bayesian clustering of cat breeds. Graphs of both the mean Ln(K) and ⁇ calculations based on the results of Bayesian clustering. Points where a peaks in a ⁇ plot occur indicate population stratification with higher likelihood than those where valleys occur.
  • Figure 8 illustrates Bayesian clustering of cat breeds. Clustering of breeds at
  • Figures 9A-B Figure 9A illustrates alternate plots of Bayesian clustering analysis for SNPs.
  • Figure 9B illustrates alternate plots of Bayesian clustering analysis for STRs.
  • Figures 10A-B illustrate principal coordinate analysis of cat breeds and worldwide random bred cat populations. Color shades indicate the population membership of the respective random bred populations.
  • Figures 11 A-B Figure 11 A illustrates crossed assignment rate between breeds as a function of the Reynolds distance between populations using SNPs.
  • Figure 1 IB illustrates crossed assignment rate between breeds as a function of the Reynolds distance between populations using STRs.
  • the present invention is based, in part, on the discovery of a panel of biomarkers useful for the assignment of domestic cats to specific breeds or world populations based on the frequency of genetic markers in their genome. Assignment testing utilizes microsatellite and/or single nucleotide polymorphism (SNP) biomarkers, as well as genetic biomarkers that are known to confer a physical characteristic or disease state in the cat. The combined panel of over 200 different genetic tests can be used to determine if a cat is from a specific breed or random bred population of origin within a database of approximately 2000 cats.
  • SNP single nucleotide polymorphism
  • the genotypes of the panel of biomarkers are determined in a biological sample of the cat (e.g., blood, tissue, hair bulb, buccal swab) comprising genomic DNA.
  • the genotypic "signature" over the panel of biomarkers of the test cat is compared against a database of the same panel of biomarkers with identified frequency associations with known cat breeds and random bred populations of origin.
  • the frequency of the DNA variants of the test cat are compared to the database to match the test cat to the population with the most similar frequencies, allowing assignment to one or more breeds and/or ancestral lineages of origin.
  • biomarker panels described herein it is possible to determine the geographical region of the genetic origins of the test cat, whether the test cat is highly related to a known breed, or whether the test cat has a parent or grandparent that is of a known breed.
  • the present genetic assignment tests also find use breeding strategies, e.g. , to facilitate the selection of a mating partner that is genetically dissimilar, or as a new foundation for a breed stock.
  • the methods find use in determining the contributing feline populations of origin of any feline, e.g., any member of the family Felidae. Oftentimes, the feline will be a domesticated feline. In various embodiments, the feline is a member of the genus Felis. For example, the feline may be a member of Felis silvestris or Felis catus. The feline further can have one or more identifiable phenotypic or morphological features associated with one or more recognized cat breeds, by a cat registry.
  • the feline may have genetic contributions from a cat breed recognized by one or more cat registries selected from the group consisting of The International Cat Association (TICA; tica.org); the Cat Fanciers' Association (CFA; cfa.org); The Australian Cat Federation (ACF; acf.asn.au); Co-Ordinating Cat Council of Australia (CCC of A; cccofa.asn.au); Federation
  • NSW CFA National Feline Association
  • QFA Queensland Feline Association
  • Illustrative breeds include without limitation Abyssinian, American Bobtail,
  • Additional populations can also be added. For example, breeds that are considered preliminary or under development, as well as breeds specific to a particular geographic location (e.g., breeds or populations specific to an island location), can be added to the databases described herein, first as a preliminary breed and then as an established breed. For example, the Selkirk Rex and American Curl breeds are under development. Also, additional analyses could be used to further refine population and breed definitions when compared on a less global and more regional scale.
  • the feline is a hybrid, e.g. , having genomic contributions from one or more wild felids.
  • the Bengal is a cross of various cat breeds and random bred cats with various sub-species of the Asian Leopard cat (Felis bengalensis, a.k.a. Prionailurus bengalensis).
  • the Chaussie breed is a cross of various cat breeds and random bred cats with various sub-species of the Jungle cat (Felis chaus).
  • the Savannah breed is a cross of various cat breeds and random bred cats with various subspecies of the Serval (Felis Serval).
  • Some cat breeds are mixtures of these various hybrid breeds, e.g., the Desert Lynx.
  • the methods may comprise the step of obtaining a biological sample comprising genomic DNA from the feline to be tested.
  • the biological sample may be obtained in the laboratory conducting the analysis or by another party (e.g., a veterinarian, a guardian of the feline).
  • the biological sample can be from solid tissue or a biological fluid that contains a nucleic acid comprising a single nucleotide polymorphism (SNP) described herein, e.g., a genomic DNA sample comprising a plurality of the genetic markers listed in Table 1 , particularly the SNPs depicted in SEQ ID NOs: 1-148.
  • SNP single nucleotide polymorphism
  • the biological sample can be tested by the methods described herein and include body fluids including whole blood, serum, plasma, cerebrospinal fluid, urine, lymph fluids, semen, and various external secretions of the respiratory, intestinal and genitourinary tracts, tears, saliva, milk, white blood cells, myelomas, and the like; and biological fluids such as cell extracts, cell culture supematants; fixed tissue specimens; and fixed cell specimens.
  • Biological samples can also be from solid tissue, including hair bulb, skin, cheek swab, biopsy or autopsy samples or frozen sections taken for histologic purposes. These samples are well known in the art.
  • a biological sample is obtained from any feline to be tested for the genotype of the genetic markers as described herein.
  • a biological sample can be suspended or dissolved in liquid materials such as buffers, extractants, solvents and the like.
  • Genetic markers useful for the determination of the contribution of one of more feline populations or breeds of origin are listed in Table 1.
  • the methods of the invention analyze in a test feline the genotype of a plurality of genetic markers depicted as SEQ ID NOs: l-148 in Table 1 , also identified by their chromosomal location.
  • TCTTCATG [A/G] CAG CAG AACACATTCCTTG AG G AAAAAACAATATGTCTT CACTTTATTTTGTCCCCTAAT
  • chrA3_75156179 G A 0.240 0.228 0.249 0.533 0.462 0.433 0.029 0.000 0.029 0.000 0.000 0.115 0.026 0.192 0.222 0.042 0.583 0.250 0.44 chrA3_91058022 A C 0.286 0.391 0.237 0.667 0.538 0.038 0.265 0.025 0.361 0.194 0.000 0.000 0.643 0.211 0.077 0.444 0.304 0.711 0.735 0.75 chrA3_99507784 A T 0.324 0.251 0.356 0.071 0.192 0.367 0.088 0.625 0.147 0.342 0.042 0.033 0.625 0.158 0.077 0.500 0.435 0.206 0.188 0.20 chrB1_10420438 C T 0.074 0.117 0.054 0.000 0.038 0.615 0.156 0.025 0.083 0.000 0.083 0.333 0.038 0.333 0.045 0.000 0.000 0.000 0.059 0.05 0.05
  • chrF1 82716202 C A 0.196 0.181 0.204 0.067 0.038 0.067 0.389 0.026 0.222 0.000 0.333 0.067 0.269 0.139 0.000 0.029 0.000 0.395 0.471 0.36 chrF1 91517402 C T 0.188 0.173 0.192 0.467 0.308 0.100 0.133 0.447 0.333 0.079 0.250 0.067 0.077 0.250 0.154 0.105 0.000 0.147 0.235 0.11 chrF2 26886470 G A 0.298 0.322 0.282 0.100 0.115 0.607 0.059 0.650 0.361 0.889 0.417 0.000 0.000 0.361 0.875 0.194 0.739 0.000 0.088 0.05 chrF2 38395360 C T 0.295 0.319 0.285 0.167 0.269 0.357 0.313 0.053 0.778 0.000 0.545 0.607 0.091 0.868 0.045 0.194 0.000 0.278 0.500 0.38 chrF
  • chrA1_223501140 G 0.222 0.100 0.067 0.333 0.118 0.267 0.071 0.588 0.000 0.219 0.147 0.075 0.162 0.082 0.074 0.039 0.111 0.167 0.076 0. chrA1_223506906 G 0.000 0.000 0.033 0.000 0.000 0.000 0.000 0.091 0.625 0.000 0.179 0.194 0.147 0.154 0.195 0.329 0.367 0.708 0.425 0.183 0. chrA1_225057933 A 0.111 0.067 0.267 0.056 0.029 0.133 0.133 0.000 0.000 0.000 0.190 0.132 0.221 0.218 0.284 0.401 0.000 0.259 0.139 0.
  • chrA1_235579538 A 0.000 0.036 0.036 0.000 0.000 0.033 0.036 0.000 0.071 0.059 0.000 0.132 0.054 0.144 0.090 0.299 0.324 0.125 0.056 0. chrA1_27523501 A 0.150 0.267 0.733 0.735 0.382 0.800 0.667 0.531 0.000 0.406 0.667 0.700 0.426 0.628 0.636 0.745 0.568 0.649 0.786 0. chrA1_68485376 G 0.000 0.107 0.067 0.000 0.118 0.000 0.067 0.000 0.235 0.053 0.184 0.141 0.076 0.009 0.000 0.000 0.006 0.015 0.
  • chrA1_69424718 T 0.000 0.500 0.400 0.433 0.118 0.367 0.500 0.000 0.143 0.088 0.316 0.556 0.292 0.343 0.332 0.755 0.542 0.335 0.412 0.
  • chrA1_7429296 T 0.050 0.167 0.100 0.000 0.382 0.000 0.000 0.000 0.375 0.533 0.105 0.028 0.183 0.150 0.161 0.244 0.581 0.296 0.028 0. chrA1_8742286 T 0.650 0.033 0.167 0.611 0.000 0.400 0.267 0.031 0.500 0.353 0.250 0.250 0.273 0.406 0.426 0.683 0.257 0.476 0.514 0.
  • chrA2_152258936 c 0.833 0.333 0.600 0.853 0.324 0.333 0.357 1.000 0.714 0.567 0.711 0.361 0.409 0.399 0.319 0.565 0.446 0.314 0.471 0.
  • chrA2 201526186 T 0.050 0.233 0.200 0.000 0.206 0.000 0.133 0.176 0.000 0.412 0.214 0.361 0.207 0.156 0.269 0.161 0.176 0.253 0.103 0.
  • chrA2_202225770 T 0.650 0.633 0.333 0.094 0.324 0.733 0.308 0.107 0.000 0.563 0.300 0.375 0.317 0.319 0.232 0.203 0.108 0.440 0.672 0.
  • chrA2_44241149 T 0.000 0.000 0.000 0.000 0.000 0.000 0.067 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.062 0.016 0.009 0.006 0.000 0.017 0.014 0.
  • chrA2_554046 c 0.050 0.000 0.200 0.111 0.059 0.000 0.133 0.000 0.000 0.147 0.150 0.053 0.133 0.169 0.217 0.186 0.027 0.144 0.028 0. chrA3_101420069 G 0.000 0.000 0.000 0.000 0.000 0.000 0.200 0.000 0.000 0.118 0.000 0.000 0.056 0.057 0.065 0.000 0.054 0.087 0.000 0.
  • chrA3 11480952 T 0.000 0.000 0.000 0.000 0.029 0.000 0.067 0.000 0.000 0.059 0.024 0.000 0.053 0.021 0.027 0.000 0.014 0.000 0.048 0. chrA3_12082294 A 0.313 0.467 0.300 0.400 0.406 0.000 0.286 0.833 0.000 0.118 0.071 0.225 0.336 0.171 0.252 0.126 0.095 0.063 0.103 0. chrA3_130195244 C 0.222 0.038 0.100 0.077 0.059 0.167 0.115 0.192 0.700 0.156 0.179 0.059 0.199 0.284 0.368 0.075 0.111 0.124 0.138 0.
  • chrA3_159537633 C 0.050 0.333 0.433 0.222 0.176 0.233 0.367 0.088 0.000 0.344 0.475 0.825 0.472 0.595 0.650 0.699 0.405 0.506 0.243 0. chrA3_162208567 G 0.167 0.786 0.200 0.441 0.794 0.000 0.536 0.100 0.000 0.594 0.382 0.250 0.377 0.194 0.196 0.260 0.068 0.064 0.016 0. chrA3_38781591 A 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.158 0.053 0.022 0.016 0.004 0.006 0.000 0.011 0.000 0.
  • chrA3_75156179 A 0.350 0.000 0.467 0.281 0.118 0.000 0.467 0.233 0.000 0.267 0.333 0.605 0.266 0.375 0.348 0.243 0.068 0.127 0.069 0. chrA3_91058022 C 0.313 0.433 0.633 0.233 0.147 0.133 0.633 0.706 0.786 0.294 0.625 0.342 0.484 0.256 0.241 0.104 0.230 0.106 0.121 0. chrA3_99507784 T 0.100 0.233 0.467 0.333 0.235 0.433 0.033 0.219 0.000 0.176 0.250 0.333 0.231 0.302 0.296 0.578 0.162 0.355 0.456 0.
  • chrB1_10420438 T 0.444 0.267 0.333 0.000 0.125 0.000 0.167 0.000 0.500 0.118 0.071 0.025 0.104 0.082 0.034 0.023 0.027 0.034 0.014 0.
  • chrB1_12214271 G 0.722 0.333 0.533 0.382 0.688 0.267 0.607 0.941 0.714 0.441 0.525 0.105 0.401 0.392 0.591 0.350 0.514 0.554 0.333 0. chrB1_195678303 C 0.056 0.067 0.133 0.500 0.029 0.033 0.143 0.000 0.667 0.088 0.175 0.132 0.102 0.258 0.230 0.358 0.351 0.116 0.071 0.
  • chrB1_199564532 A 0.200 0.067 0.100 0.206 0.147 0.000 0.250 0.000 0.000 0.147 0.095 0.075 0.156 0.101 0.154 0.003 0.027 0.052 0.000 0. chrB1_202966562 T 0.100 0.400 0.267 0.833 0.382 0.167 0.462 0.125 0.000 0.500 0.250 0.316 0.381 0.263 0.198 0.183 0.149 0.184 0.235 0.
  • chrB1_54775572 A 0.000 0.100 0.033 0.059 0.176 0.000 0.000 0.000 0.324 0.000 0.059 0.190 0.075 0.188 0.204 0.135 0.059 0.216 0.000 0.097 0. chrB1_80161671 A 0.000 0.231 0.000 0.036 0.594 0.033 0.222 0.583 0.000 0.147 0.056 0.028 0.169 0.096 0.058 0.241 0.068 0.122 0.097 0. chrB1_88148379 C 0.150 0.267 0.567 0.265 0.382 0.500 0.643 0.235 0.333 0.156 0.525 0.605 0.360 0.477 0.483 0.443 0.622 0.369 0.182 0.
  • chrB2_138312489 A 0.400 0.433 0.800 0.433 0.353 0.567 0.400 0.125 0.750 0.735 0.275 0.750 0.422 0.462 0.422 0.282 0.284 0.698 0.700 0. chrB2_146660650 T 0.050 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.467 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.014 0.034 0.139 0. chrB2_41509834 A 0.333 0.233 0.600 0.000 0.000 0.833 0.269 0.857 0.714 0.412 0.605 0.400 0.278 0.257 0.155 0.624 0.351 0.464 0.614 0.
  • chrB2_45093345 G 0.333 0.700 0.500 0.063 0.625 0.067 0.808 0.393 0.100 0.469 0.389 0.474 0.542 0.433 0.404 0.093 0.257 0.227 0.258 0. chrB2_6949528 A 0.000 0.467 0.000 0.083 0.324 0.000 0.214 0.000 0.000 0.029 0.262 0.100 0.201 0.195 0.111 0.029 0.149 0.029 0.014 0. chrB3_104483970 A 0.333 0.133 0.367 0.719 0.000 0.821 0.233 0.471 0.143 0.029 0.050 0.132 0.202 0.328 0.321 0.172 0.122 0.506 0.855 0.
  • chrB3_111000326 G 0.222 0.133 0.033 0.333 0.029 0.567 0.067 0.206 0.000 0.000 0.025 0.100 0.111 0.200 0.261 0.171 0.149 0.333 0.676 0. chrB3 13666494 G 0.667 0.667 0.767 0.563 0.706 0.667 0.286 0.563 0.083 0.353 0.361 0.225 0.475 0.439 0.504 0.255 0.243 0.560 0.765 0. chrB3_39203469 A 0.000 0.200 0.067 0.393 0.147 0.000 0.036 0.000 0.083 0.219 0.333 0.294 0.184 0.378 0.625 0.211 0.108 0.071 0.100 0.
  • chrB3_51317931 T 0.786 0.250 0.233 0.056 0.029 0.893 0.167 1.000 0.125 0.219 0.353 0.325 0.138 0.294 0.276 0.407 0.095 0.390 0.750 0. chrB3_57141954 c 0.350 0.571 0.667 0.882 0.471 0.067 0.533 0.767 0.000 0.531 0.324 0.588 0.377 0.173 0.171 0.242 0.230 0.137 0.069 0. chrB3_77094074 c 0.417 0.036 0.033 0.115 0.467 0.000 0.000 0.300 0.143 0.105 0.000 0.168 0.006 0.022 0.007 0.139 0.056 0.067 0.
  • chrB4 144693308 A 0.625 0.167 0.133 0.156 0.029 0.833 0.367 0.333 0.750 0.406 0.190 0.289 0.311 0.426 0.460 0.450 0.473 0.335 0.469 0. chrB4_146486983 T C 0.050 0.033 0.067 0.528 0.156 0.767 0.269 0.433 0.000 0.029 0.200 0.075 0.193 0.194 0.124 0.288 0.541 0.134 0.641 0. chrB4_147206961 C 0.556 0.179 0.292 0.719 0.000 0.900 0.500 0.938 0.917 0.222 0.294 0.100 0.350 0.276 0.434 0.293 0.176 0.544 0.750 0.
  • chrB4_149532846 T 0.200 0.000 0.233 0.000 0.324 0.000 0.115 0.063 0.000 0.067 0.000 0.025 0.126 0.056 0.030 0.016 0.014 0.023 0.057 0. chrB4_1687419 T 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.115 0.000 0.000 0.063 0.000 0.029 0.108 0.141 0.145 0.013 0.000 0.009 0.000 0. chrB4_20001848 c 0.000 0.000 0.000 0.000 0.063 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.046 0.008 0.000 0.003 0.000 0.029 0.029 0.
  • chrB4_40319102 T 0.688 0.643 0.767 0.000 0.412 0.867 0.467 0.813 0.500 0.118 0.316 0.368 0.468 0.470 0.600 0.500 0.730 0.560 0.818 0. chrB4_47638578 G 0.100 0.367 0.067 0.000 0.559 0.000 0.115 0.000 0.000 0.029 0.048 0.026 0.086 0.038 0.004 0.006 0.000 0.017 0.014 0.
  • chrCU 16355295 C T 0.500 0.233 0.200 0.000 0.500 0.500 0.500 0.300 0.265 0.000 0.206 0.350 0.667 0.332 0.262 0.272 0.203 0.284 0.320 0.235 0. chrC1_123164748 C T 0.150 0.167 0.067 0.000 0.088 0.000 0.467 0.588 0.000 0.059 0.389 0.275 0.261 0.237 0.196 0.267 0.000 0.229 0.242 0. chrC1_181852965 G
  • a 0.500 0.400 0.500 0.125 0.417 0.125 0.167 0.591 0.000 0.308 0.136 0.000 0.406 0.108 0.167 0.022 0.000 0.113 0.056 0.
  • chrC1_190502133 G A 0.300 0.133 0.000 0.139 0.235 0.133 0.067 0.000 0.000 0.200 0.275 0.176 0.381 0.293 0.576 0.306 0.215 0.028 0. chrC1_215441574 C A 0.056 0.700 0.367 0.118 0.265 0.200 0.462 1.000 0.125 0.588 0.206 0.583 0.394 0.346 0.272 0.235 0.459 0.323 0.574 0. chrC1_216852686 G A 0.250 0.607 0.500 0.375 0.265 0.000 0.375 0.607 0.750 0.133 0.605 0.529 0.356 0.339 0.507 0.312 0.200 0.231 0.340 0.
  • chrC1_24148281 T C 0.063 0.133 0.333 0.029 0.324 0.000 0.385 0.000 0.000 0.281 0.059 0.147 0.180 0.222 0.209 0.247 0.292 0.324 0.059 0. chrC1_28702055 G T 0.000 0.000 0.000 0.000 0.000 0.294 0.000 0.133 0.000 0.000 0.382 0.050 0.100 0.122 0.041 0.000 0.129 0.027 0.029 0.043 0. chrC1_34981315 A G 0.000 0.000 0.000 0.706 0.000 0.067 0.000 0.000 0.000 0.000 0.025 0.000 0.046 0.050 0.099 0.000 0.000 0.012 0.103 0.
  • chrC2 156491175 T C 0.786 0.433 0.167 0.765 0.412 0.200 0.464 1.000 0.600 0.545 0.405 0.447 0.381 0.408 0.307 0.672 0.662 0.667 0.313 0. chrC2_187325 C
  • chrC2_262401 G A 0.444 0.067 0.133 0.059 0.094 0.333 0.107 0.531 0.571 0.059 0.125 0.306 0.188 0.283 0.277 0.122 0.153 0.280 0.591 0.
  • chrC2_5215469 T C 0.050 0.000 0.400 0.344 0.088 0.800 0.179 0.286 0.417 0.235 0.286 0.395 0.241 0.342 0.250 0.728 0.500 0.313 0.838 0. chrD1_101321498 A G 0.250 0.607 0.000 0.618 0.765 0.100 0.462 0.000 0.643 0.500 0.375 0.368 0.441 0.279 0.281 0.258 0.432 0.134 0.061 0. chrD1_104941557 C T 0.200 0.100 0.000 0.028 0.088 0.000 0.107 0.000 0.000 0.438 0.024 0.105 0.144 0.197 0.147 0.136 0.243 0.052 0.014 0.
  • chrD1_105498119 T C 0.000 0.231 0.033 0.472 0.156 0.000 0.100 0.000 0.000 0.324 0.095 0.100 0.182 0.094 0.180 0.040 0.081 0.177 0.042 0. chrD1_10789012 G
  • chrDU 1484008 C T 0.167 0.067 0.000 0.176 0.000 0.133 0.000 0.250 0.071 0.088 0.156 0.025 0.068 0.073 0.044 0.178 0.189 0.247 0.081 0.
  • chrD1_117527468 G A 0.100 0.067 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.125 0.000 0.040 0.01 1 0.004 0.003 0.000 0.000 0. chrD1_125811329 G A 0.167 0.133 0.233 0.094 0.059 0.633 0.192 0.733 0.500 0.206 0.150 0.200 0.308 0.151 0.206 0.096 0.324 0.169 0.518 0. chrD1_126256993 T C 0.833 0.267 0.333 0.559 0.059 0.667 0.500 0.676 0.250 0.375 0.325 0.056 0.233 0.228 0.188 0.144 0.378 0.221 0.819 0.
  • chrD1_126847301 T C 0.000 0.000 0.000 0.000 0.059 0.179 0.1 15 0.000 0.000 0.147 0.000 0.147 0.100 0.137 0.218 0.010 0.054 0.052 0.043 0. chrD1_15984279 A G 0.222 0.100 0.000 0.794 0.059 0.033 0.417 0.000 0.167 0.235 0.289 0.316 0.245 0.278 0.265 0.050 0.014 0.100 0.368 0.
  • chrD1_16242433 A 0.167 0.333 0.583 0.125 0.118 0.792 0.409 1.000 0.300 0.300 0.235 0.346 0.336 0.256 0.273 0.139 0.143 0.198 0.517 0. chrD1_18390852 G 0.167 0.300 0.233 0.056 0.765 0.067 0.292 0.563 0.000 0.200 0.175 0.105 0.223 0.171 0.111 0.006 0.108 0.080 0.000 0. chrD1_18570323 G 0.300 0.286 0.167 0.361 0.147 0.533 0.500 0.029 0.500 0.324 0.214 0.475 0.401 0.409 0.561 0.243 0.527 0.430 0.379 0.
  • chrD1_66177762 A 0.000 0.300 0.000 0.028 0.294 0.000 0.033 0.000 0.000 0.029 0.048 0.075 0.161 0.112 0.104 0.010 0.097 0.052 0.014 0. chrD2_1020904 G 0.000 0.400 0.167 0.188 0.000 0.033 0.321 0.813 0.571 0.382 0.619 0.605 0.420 0.437 0.689 0.631 0.703 0.667 0.329 0. chrD2_105772916 G 0.600 0.143 0.167 0.969 0.176 0.933 0.267 0.500 0.500 0.250 0.357 0.395 0.192 0.272 0.372 0.284 0.338 0.412 0.426 0.
  • chrD2_1752007 A 0.200 0.133 0.300 0.625 0.088 0.533 0.000 0.000 0.000 0.088 0.167 0.053 0.135 0.056 0.043 0.133 0.041 0.147 0.250 0. chrD2_56777338 T 0.150 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.00 0.00 0.00 0.00 0. chrD2_717969 T 0.643 0.167 0.667 0.906 0.471 0.933 0.200 0.563 0.250 0.781 0.368 0.658 0.402 0.252 0.542 0.256 0.136 0.432 0.719 0.
  • chrD2_74293444 T 0.200 0.200 0.100 0.059 0.059 0.633 0.286 0.000 0.071 0.235 0.250 0.150 0.208 0.151 0.155 0.122 0.189 0.134 0.118 0. chrD2_91989307 A 0.100 0.067 0.133 0.029 0.118 0.200 0.000 0.000 0.000 0.031 0.050 0.000 0.133 0.041 0.065 0.013 0.041 0.029 0.014 0. chrD3_103840114 T 0.150 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.750 0.000 0.000 0.100 0.100 0.022 0.040 0.043 0.039 0.135 0.046 0.000 0.
  • chrD3_122502120 T 0.100 0.143 0.000 0.000 0.000 0.133 0.067 0.118 0.071 0.125 0.275 0.075 0.176 0.236 0.243 0.313 0.392 0.310 0.313 0. chrD3_1810839 G 0.071 0.423 0.500 0.000 0.800 0.000 0.643 0.292 0.167 0.667 0.292 0.750 0.603 0.528 0.427 0.065 0.129 0.211 0.143 0. chrD3_24565823 A 0.250 0.267 0.333 0.000 0.235 0.100 0.033 0.059 0.000 0.176 0.024 0.026 0.151 0.024 0.030 0.003 0.000 0.023 0.028 o.
  • chrD3_24823793 G 0.050 0.000 0.000 0.056 0.000 0.367 0.033 0.133 0.583 0.125 0.025 0.025 0.073 0.184 0.186 0.197 0.541 0.339 0.250 0. chrD3_28838660 C 0.100 0.033 0.067 0.147 0.000 0.200 0.036 0.679 0.500 0.094 0.000 0.000 0.022 0.011 0.009 0.000 0.041 0.100 0.343 0. chrD4_41078218 C 0.700 0.536 0.733 0.231 0.438 0.400 0.654 0.000 0.900 0.038 0.429 0.550 0.458 0.491 0.482 0.493 0.919 0.402 0.212 0.
  • chrD4_42000379 C 0.000 0.033 0.200 0.233 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.324 0.167 0.139 0.077 0.134 0.106 0.038 0.014 0.078 0.015 O.
  • chrD4_63622083 A 0.000 0.429 0.500 0.292 0.294 0.000 0.179 0.029 0.333 0.000 0.075 0.139 0.241 0.082 0.065 0.069 0.083 0.135 0.061 O.
  • chrE1_130875919 A 0.000 0.233 0.000 0.000 0.088 0.000 0.067 0.000 0.000 0.250 0.225 0.083 0.271 0.103 0.303 0.013 0.000 0.061 0.061 O.
  • chrE1_131587399 A 0.056 0.269 0.100 0.000 0.382 0.000 0.000 0.000 0.000 0.000 0.176 0.083 0.000 0.141 0.047 0.022 0.013 0.000 0.023 0.056 O.
  • chrE1_48228153 A 0.200 0.067 0.033 0.382 0.147 0.500 0.367 0.676 0.333 0.147 0.071 0.474 0.205 0.196 0.147 0.145 0.176 0.198 0.530 0. chrE1_48700963 T 0.222 0.100 0.067 0.111 0.029 0.000 0.036 0.000 0.000 0.000 0.000 0.025 0.050 0.096 0.060 0.048 0.000 0.027 0.034 0.000 O.
  • chrE1_5453028 A 0.000 0.286 0.400 0.278 0.471 0.067 0.462 0.000 1.000 0.647 0.633 0.350 0.522 0.376 0.435 0.211 0.284 0.157 0.029 O.
  • chrE2_22632289 A 0.850 0.500 0.300 0.094 0.353 0.833 0.500 0.031 0.917 0.529 0.200 0.389 0.373 0.389 0.421 0.374 0.608 0.371 0.724 0. chrE2_34027888 A 0.000 0.433 0.167 0.156 0.265 0.000 0.033 0.000 0.000 0.000 0.026 0.025 0.059 0.022 0.089 0.000 0.000 0.076 0.014 O.
  • chrE2_35914023 C T 0.167 0.000 0.000 0.278 0.059 0.033 0.600 0.1 18 0.083 0.107 0.306 0.333 0.275 0.241 0.152 0.050 0.292 0.194 0.181 0. chrE2_36986631 G T 0.200 0.786 0.533 0.333 0.625 0.200 0.467 0.313 0.143 0.324 0.750 0.526 0.410 0.603 0.618 0.392 0.257 0.471 0.281 0. chrE2_38860686 C T 0.150 0.133 0.133 0.056 0.735 0.000 0.179 0.000 0.500 0.059 0.139 0.000 0.297 0.049 0.039 0.090 0.081 0.059 0.015 0.
  • chrE2_39211557 C T 0.389 0.464 0.542 0.300 0.708 0.464 0.500 0.000 0.833 0.462 0.227 0.333 0.440 0.422 0.495 0.411 0.324 0.402 0.407 0. chrE2_65436639 c T 0.500 0.067 0.233 0.000 0.088 0.400 0.133 0.938 0.071 0.235 0.176 0.325 0.227 0.298 0.283 0.330 0.189 0.310 0.147 0.
  • chrE2_7950477 c A 0.722 0.500 0.467 0.806 0.471 0.667 0.433 0.063 0.400 0.781 0.528 0.368 0.457 0.497 0.417 0.566 0.597 0.579 0.677 O.
  • chrE2_8422942 A G 0.050 0.000 0.133 0.028 0.000 0.033 0.000 0.029 0.000 0.000 0.139 0.184 0.078 0.064 0.066 0.320 0.054 0.017 0.028 0.
  • chrE3_36044809 G A 0.000 0.400 0.536 0.028 0.382 0.067 0.133 0.344 0.286 0.500 0.175 0.200 0.237 0.41 1 0.548 0.530 0.243 0.282 0.191 o.
  • chrE3_55434272 C T 0.250 0.500 0.600 0.471 0.412 0.333 0.583 0.000 0.100 0.633 0.553 0.21 1 0.385 0.383 0.421 0.039 0.324 0.317 0.303 O.
  • chrE3_67006512 C T 0.056 0.067 0.357 0.000 0.235 0.000 0.091 0.000 0.100 0.265 0.333 0.129 0.123 0.109 0.083 0.045 0.032 0.030 o.
  • chrF1 20309325 G A 0.056 0.067 0.233 0.028 0.000 0.667 0.000 0.029 0.000 0.029 0.071 0.306 0.075 0.081 0.022 0.076 0.097 0.034 0.069 o.
  • chrF1_21799641 C T 0.400 0.300 0.400 0.469 0.147 0.067 0.433 0.281 0.000 0.156 0.071 0.050 0.331 0.079 0.113 0.048 0.108 0.098 0.042 0. chrF1_26100599
  • chrF1_27124984 C T 0.150 0.033 0.200 0.059 0.029 0.767 0.071 0.577 0.929 0.125 0.094 0.026 0.206 0.253 0.297 0.373 0.292 0.429 0.667 0. chrF1_38051725 A G 0.444 0.286 0.400 0.882 0.382 0.333 0.633 0.250 0.000 0.500 0.675 0.500 0.541 0.644 0.671 0.317 0.122 0.305 0.530 0.
  • chrF1 565223 G A 0.550 0.179 0.733 0.361 0.706 0.750 0.692 0.824 0.417 0.563 0.632 0.600 0.463 0.438 0.425 0.463 0.608 0.536 0.471 o.
  • chrF1_82068276 G T 0.938 0.444 0.143 0.000 0.417 0.700 0.1 15 0.882 0.333 0.269 0.056 0.079 0.187 0.065 0.059 0.007 0.015 0.250 0.379 0. chrF1_82716202 C A 0.000 0.250 0.167 0.853 0.206 0.067 0.107 0.000 0.000 0.324 0.132 0.026 0.288 0.191 0.125 0.339 0.243 0.100 0.100 0.100 0.100 0.
  • chrF1_91517402 C T 0.350 0.133 0.233 0.029 0.382 0.033 0.107 0.000 0.000 0.235 0.200 0.225 0.214 0.223 0.184 0.176 0.351 0.327 0.044 o.
  • chrF2_26886470 G A 0.444 0.133 0.433 0.344 0.118 0.833 0.143 0.781 0.750 0.235 0.024 0.100 0.104 0.153 0.104 0.459 0.405 0.494 0.591 0. chrF2_38395360 C T 0.643 0.833 0.367 0.235 0.765 0.033 0.269 0.000 0.214 0.156 0.333 0.025 0.349 0.270 0.279 0.334 0.338 0.360 0.029 0.
  • chrF2_78303221 T C 0.000 0.633 0.500 0.194 0.500 0.000 0.769 0.265 0.857 0.469 0.595 0.275 0.478 0.531 0.470 0.743 0.716 0.429 0.273 0.
  • chrF2_79632602 G C 0.000 0.167 0.000 0.063 0.125 0.000 0.000 0.000 0.000 0.059 0.000 0.000 0.025 0.01 1 0.004 0.062 0.000 0.006 0.000 O.
  • SNPs from Table 1 are determined. In some embodiments, the expression levels of all listed SNPs of SEQ ID NOs: 1-148 listed in Table 1 are determined.
  • one or more morphological features and/or the genotype of one or more phenotypic markers can be determined.
  • the morphologic and phenotypic markers can relate to hair length, coat color, coat texture, ear, paw and tail morphology, or a known disease marker.
  • the feline may be evaluated for coat color (e.g., chocolate, cinnamon, dilute, orange, white), coat patterning (e.g., agouti, tabby, spotted, ticked, calico, point coloring), coat texture (e.g., straight or rex), coat length (e.g., hairless, short or long), ear morphology (e.g., normal, curled or folded, paw morphology (e.g., normal or polydactyl), and tail morphology (e.g., manx, bobtail, long).
  • coat color e.g., chocolate, cinnamon, dilute, orange, white
  • coat patterning e.g., agouti, tabby, spotted, ticked, calico, point coloring
  • coat texture e.g., straight or rex
  • coat length e.g., hairless, short or long
  • ear morphology e.g., normal, curled or folded
  • paw morphology e
  • Some phenotypic markers can be evaluated by genetic analysis, without visual inspection of the feline.
  • the methods may further comprise determining the genotype of one or more phenotypic markers identified in Table 3, i.e., as SEQ ID NOs: 149-202.
  • the genotypes of at least about 3, 5, 10, 15, 20, 25, 30, 40, 50, or more, phenotypic markers, e.g., listed in Table 3, are determined.
  • phenotypic markers e.g., listed in Table 3.
  • the expression levels of all listed phenotypic marker of SEQ ID NOs: 149-202 are determined.
  • a genetic marker for long hair e.g., the A475C FGF5 mutation
  • the long hair mutations can also be used to distinguish different breeds that are long haired varietes within the breed family. For example, a Balinese is a longhaired Siamese and a Cymric is a longhaired Manx.
  • G715T TYR mutation which defines Burmese points
  • C298T TYRP1 is common to the red Abyssinian.
  • Certain dominant traits can be homozygous or heterozygous, such as the ear curl of American Curls or the bobtail of the Japanese Bobtail.
  • Tonkinese felines are genetically compound heterozygous for the G940A and the G715T TYR mutations and can produce both pointed and sepia cats, and genetically resemble a Siamese or Burmese, respectively.
  • Tonkinese variants are registered as Siamese or Burmese.
  • Additional phenotypic SNPs that find use include the Norwegian Forest Cat color variant amber (Peterschmitt et al. (2009) Animal Genetics, 40:547-552), three additional long-haired mutations (Kehler et al. (2007) Journal of Heredity, 98:555-566), and the mutations responsible for hairless of Sphynx and rexing of the Devon Rex (Gandolfi et al., Mamm Genome. (2010) (9-10):509-15).
  • a mutation in KIT (c.1035_1036delinsCA) for Birman glove white spotting should be restricted to the Birman breed. Phenotypic genetic markers, as well as disease mutations, find use to further delineate cat breeds.
  • morphological and/or phenotypic markers find use to distinguish between genetically related feline breeds, e.g., (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese; (iv) Singapura and Burmese; (v) Birman and Korat, and (vi) Siamese and Havana Brown.
  • determination of whether the feline has the phenotype for long hair can be used to distinguish between Persian and Exotic Shorthair; determination of whether the feline has curled ear morphology can be used to distinguish between British SH and Scottish Fold; determination of fur color and/or pattern can be used to distinguish between Australian Mist and Burmese; between Singapura and Burmese; between Birman and Korat; or between Siamese and Havana Brown.
  • a Burmese will lack barring and/or spotting, a Singapura possesses the dominant ticked tabby gene, Ta; and an Australian Mist will have spotting and barring.
  • a Birman and a Siamese will have the mutation for Siamese points (i.e, homozygous for the G940A TYR mutation), a Korat and a Havana Brown will not.
  • Phen_MLPH_T83del GGCAGAGATGGGGAAAAAACTGGATCTTTCCAAGCTCACGGACGACGAG
  • Phen_MC1 R_G250A CCTGGGGCTGGTGAGCGTGGTGGAGAACGTGCTGGTGGTGGCCGCCAT
  • Phen GBE1 Ins NFC TTAAGAATATTCATTCTAGGGGCGCCTGGGTGGCGCAGTCGGTTAAGCG
  • Phen_PKLR_13delE6_ CGCCCACCGGTGCCTGTTCCGTGCACGGCCCAGGCCCCAAGGTGGACA Aby GGCAATAGGACACGGGTTCCTGATTTCCTGGGGGCCCACGCCCCGTGCC
  • Phen_PKD1_C10063A CTCCCTCTGGGACCGGCCTCCTCGGAGCCGCTTCACCCGCGTCCAGCG _PER GGCCACCTGTTG[A/C]GTCCTCCTCGTCTGCCTCTTCCTGGGCGCCAATG
  • Phen_SHH_A481T_U CCAGTGGCTAATTTGTCTCAGGCCTCCGTCTTAAAGAGAC[A/T]CAGAAAT K2 GAGTAGGAAGTCCAGCGTGGTCTCAGAGAGCT
  • HMBS_189TT_SIA GCACGTGACTGATTCTCTCCTCAGTTGCTATGTCCACCACAGGGGACAAG
  • F disease SNP is frequent in the breed and may be breed specific
  • V the SNP variant has different frequencies in different breeds
  • the genotype of one or more microsatellite markers and/or short tandem repeats can be determined.
  • the genotype of one or more feline STRs selected from the group consisting of selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
  • feline microsatellites and STRs have been characterized and mapped, as described, e.g., in Menotti-Raymond, et al., Genomics (1999) 57(l):9-23; Menotti-
  • feline STRs are determined.
  • methods comprise obtaining the identity of one or both alleles in a test feline genome for each marker of a set of markers.
  • the genetic markers described herein, including the SNPs, STRs and phenotypic markers can be detected using any methods known in art, including without limitation amplification, sequencing and hybridization techniques. Detection techniques for evaluating nucleic acids for the presence of a single base change involve procedures well known in the field of molecular genetics. Methods for amplifying nucleic acids find use in carrying out the present methods. Ample guidance for performing the methods is provided in the art.
  • Exemplary references include manuals such as PCR Technology: PRINCIPLES AND APPLICATIONS FOR DNA AMPLIFICATION (ed. H. A. Erlich, Freeman Press, NY, N.Y., 1992); PCR PROTOCOLS: A GUIDE TO METHODS AND APPLICATIONS (eds. Innis, et al, Academic Press, San Diego, Calif, 1990); CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Ausubel, 1990-2008, including supplemental updates;
  • a method for assigning a feline to one or more breeds and/or populations of origin based on the genotypes of a set of gene polymorphisms comprises the steps of first isolating a genomic DNA sample from a feline, and then detecting, e.g., amplifying a region genomic DNA including the one or more of the genetic markers using an oligonucleotide pair to form nucleic acid amplification products of the one or more gene polymorphism sequences.
  • Amplification can be by any of a number of methods known to those skilled in the art including PCR, and the invention is intended to encompass any suitable methods of DNA amplification.
  • DNA amplification techniques are suitable for use with the present invention.
  • amplification techniques include methods such as polymerase chain reaction (PCR), strand displacement amplification (SDA), nucleic acid sequence based amplification (NASBA), rolling circle amplification, T7 polymerase mediated amplification, T3 polymerase mediated amplification, SP6 polymerase mediated amplification, and GoldenGate amplification assays.
  • PCR polymerase chain reaction
  • SDA strand displacement amplification
  • NASBA nucleic acid sequence based amplification
  • rolling circle amplification T7 polymerase mediated amplification
  • T3 polymerase mediated amplification T3 polymerase mediated amplification
  • SP6 polymerase mediated amplification and GoldenGate amplification assays.
  • the precise method of DNA amplification is not intended to be limiting, and other methods not listed here will be apparent to those skilled in the art and their use is within the scope of the invention.
  • PCR polymerase chain reaction
  • thermostable DNA polymerase known sequences as primers, and heating cycles, which separate the replicating deoxyribonucleic acid (DNA), strands and exponentially amplify a gene of interest.
  • Any type of PCR including quantitative PCR, RT-PCR, hot start PCR, LA-PCR, multiplex PCR, touchdown PCR, finds use. In some embodiments, real-time PCR is used.
  • the amplification products are then analyzed in order to detect the presence or absence of at least one polymorphism in the feline genome that is associated with the desired genotypes and/or phenotypes, as discussed herein.
  • the amplification products are then analyzed in order to detect the presence or absence of at least one polymorphism in the feline genome that is associated with the desired genotypes and/or phenotypes, as discussed herein.
  • the genetic markers may be detected by restriction fragment length polymorphism (RFLP) analysis of a PCR amplicon produced by amplification of genomic DNA with the oligonucleotide pair.
  • RFLP restriction fragment length polymorphism
  • the amplified DNA will further comprise labeled moieties to permit detection of relatively small amounts of product.
  • moieties are well known to those skilled in the art and include such labeling tags as fluorescent, bioluminescent, chemiluminescent, and radioactive or colorigenic moieties.
  • a variety of methods of detecting the presence and restriction digestion properties of amplification products are also suitable for use with the present invention. These can include methods such as gel electrophoresis, mass spectroscopy or the like.
  • the present invention is also adapted to the use of single stranded DNA detection techniques such as fluorescence resonance energy transfer (FRET).
  • FRET fluorescence resonance energy transfer
  • hybridization anchor and detection probes may be used to hybridize to the amplification products. The probes sequences are selected such that in the presence of the SNP, for example, the resulting hybridization complex is more stable than if there is a G or C residue at a particular nucleotide position. By adjusting the hybridization conditions, it is therefore possible to distinguish between animals with the SNP and those without.
  • a variety of parameters well known to those skilled in the art can be used to affect the ability of a hybridization complex to form. These include changes in temperature, ionic concentration, or the inclusion of chemical constituents like formamide that decrease complex stability. It is further possible to distinguish animals heterozygous for the SNP versus those that are homozygous for the same.
  • the method of FRET analysis is well known to the art, and the conditions under which the presence or absence of the SNP would be detected by FRET are readily determinable.
  • Suitable sequence methods of detection also include e.g., dideoxy
  • HPLC-based analyses include, e.g., denaturing HPLC (dHPLC) as described in e.g., Premstaller and Oefner, LC-GC Europe 1-9 (July 2002); Bennet et al, BMC Genetics 2: 17 (2001); Schrimi et al, Biotechniques 28(4):740 (2000); and Nairz et al, PNAS USA 99(16): 10575-10580 (2002); and ion-pair reversed phase HPLC-electrospray ionization mass spectrometry (ICEMS) as described in e.g., Oberacher et al.; Hum.
  • ICEMS ion-pair reversed phase HPLC-electrospray ionization mass spectrometry
  • Methods for detecting single base changes well known in the art often entail one of several general protocols: hybridization using sequence-specific oligonucleotides, primer extension, sequence-specific ligation, sequencing, or electrophoretic separation techniques, e.g., singled-stranded conformational polymorphism (SSCP) and heteroduplex analysis.
  • SSCP singled-stranded conformational polymorphism
  • exemplary assays include 5' nuclease assays, template-directed dye-terminator incorporation, molecular beacon allele-specific oligonucleotide assays, single-base extension assays, and SNP scoring by real-time pyrophosphate sequences.
  • Analysis of amplified sequences can be performed using various technologies such as microchips, fluorescence polarization assays, and matrix-assisted laser desorption ionization (MALDI) mass spectrometry.
  • MALDI matrix-assisted laser desorption ionization
  • FRET analysis can be used as a method of detection.
  • hybridization probes comprising an anchor and detection probe, the design of which art is well known to those skilled in the art of FRET analysis, are labeled with a detectable moiety, and then under suitable conditions are hybridized an amplification product containing the genetic marker of interest in order to form a hybridization complex.
  • a variety of parameters well known to those skilled in the art can be used to affect the ability of a hybridization complex to form. These include changes in temperature, ionic concentration, or the inclusion of chemical constituents like formamide that decrease complex stability. The presence or absence of the genetic marker is then determined by the stability of the hybridization complex.
  • the parameters affecting hybridization and FRET analysis are well known to those skilled in the art.
  • the amplification products and hybridization probes described herein are suitable for use with FRET analysis.
  • the methods comoprise determining the contributions of one or more feline populations (e.g., ancestral lineage and/or breed contributions) to the test feline genome by comparing the alleles at the predetermined genetic markers in the test feline genome (e.g. , a plurality of the SNPs listed in Table 1; optionally one or more phenotypic markers and/or microsatellite markers) to a database comprising feline population profiles, wherein each feline population profile comprises genotype information for alleles of the markers in the set of markers in the feline population.
  • a feline population profile may comprise genotype information for each allele of each marker in the set of markers in the feline population.
  • the genotype information in a feline population profile may comprise information such as the identity of one or both alleles of most or all of the markers in the set of markers in one or more felines that are members of that feline population, and/or estimated allele frequencies for at least one allele of most or all of the markers in the set of markers in that feline population.
  • the collection of feline population profiles can be collected in a database for use in practicing the invention. In some embodiments, the database of feline population profiles comprises one or more feline population profiles.
  • the database of feline population profiles comprises a plurality of feline population profiles, e.g., between about five and about 500 feline population profiles, such as about 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, or more, feline population profiles.
  • Determining the contributions of feline populations to the test feline genome can encompass both assigning a feline genome to one or more particular feline populations and/or determining the fraction of the feline genome that was derived from one or more feline populations.
  • the test feline is suspected of having at least about 25% of the feline genome, e.g., at least about 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100%), derived from a single defined feline population (e.g., ancestral lineage and/or breed).
  • Any algorithms useful for multi-locus genotype analysis may be used in the methods of the invention, for example, classic assignment algorithms. Suitable algorithms include those described in Rannala & Mountain (1997) Proc. Natl. Acad. Sci. U.S.A. 94:9197-9201, Paetkau et al. (2004) Molecular Ecology, 13:55-65 and Cornuet et al.
  • Cluster iterations can be combined, e.g., through the program CLUMP (Jakobsson & Rosenberg, Bioinformatics 23(14): 1801-6) and DISTRUCT (Rosenberg, (2004) Molecular Ecology Notes 4, 137-138) to create a consensus clustering. Migrants within populations can be detected, e.g., using the program Geneclass2 (Piry et al, (2004) Journal of Heredity 95, 536-539.
  • the methods of the invention comprise determining the probability that a specific feline population contributed to the genome of the test feline by determining the conditional probability that the alleles in the test feline genome would occur in the specific feline population divided by the sum of conditional probabilities that the alleles in the test feline genome would occur in each feline population in the database.
  • Some embodiments of the methods of the invention comprise discriminating between the contributions of two or more genetically related feline populations to the test feline genome by comparing the alleles in the test feline genome to a database comprising profiles of the two or more genetically related feline populations.
  • the two or more genetically related feline populations may comprise (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese;
  • sensitivity specifically indicates the percentage of individuals sampled from a breed that could be assigned back to that breed.
  • Specificity takes into account individuals sampled from other breeds that were misassigned to that breed. Sensitivity and specificity are properly used to describe the power of the testing in assignment testing. See, Example 2.
  • the test feline has at least 25% of the markers, e.g., at least about 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100% of the markers, associated with a defined ancestral lineage or breed.
  • Models that detect an individual's admixed state can be considered to group into two classes: models that require a combinatoric set of unique alleles for each of the possible mixtures of ancestral populations (Nason & Ellstrand (1993) J. Hered. 84: 1-12; Epifanio & Philipp (1997) J. Hered.
  • the latter set of models are more informative for most populations and data sets as they allow for a Bayesian posterior probabilistic assignment vector for each population/generation combination, thereby allowing for uncertainty analysis to be incorporated into the assignment vector; but existing models for the exact, recent admixture assignments of individuals from multiple ancestral populations are limited in their scope as they have been developed thus far only for two generation prediction and allow for only a few ancestral populations.
  • the methods of Anderson & Thompson (2002) are developed for a two generation, two population model with unlinked microsatellite data.
  • the methods may further comprise the step of reporting the results of the assignment analysis, e.g., to the purchaser, to the owner or guardian of the feline, to a breed registry, to a veterinarian or another interested individual.
  • the methods may further comprise the step of providing a document displaying the contributions of one or more feline populations to the genome of the test feline genome.
  • the document may be a chart, certificate, card, or any other kind of documentation.
  • the document may be electronic or paper copy.
  • the document may display the contributions of one or more feline populations to the test feline genome in a numeric format or in a graphic format.
  • the document may include photographs or other depictions, drawings, or representations of the one or more feline populations.
  • the document may also provide confidence values for the determined contributions (such as 80%, 85%, 90%> 95%, or 99% confidence).
  • the document provides a certification of the
  • the document additionally provides information regarding the one or more feline populations that contributed to the genome of the test feline or the test feline.
  • the information regarding feline populations that contributed to the genome of the test feline may include information related to the characteristics and origin of the feline population (e.g., ancestral origin and/or contributing breed(s)) or any other kind of information that would be useful knowledge concerning the test feline.
  • the information includes health-related information.
  • Many feline populations have predispositions to particular diseases or conditions. For example, heart disease in the Maine Coon and Ragdoll (Meurs et al. (2005) Human Molecular Genetics, 14:3587-3593; Meurs et al. (2007) Genomics, 90:261-264), polycystic kidney disease in the Persian (Lyons et al. 2004, supra), progressive retinal atrophy in the Abyssinian (Menotti- Raymond et al. (2007) Journal of Heredity, 98:211-220) and a craniofacial defect and hypokalemia in Burmese.
  • information regarding the contributions of one or more feline populations to the genome of the test feline genome is particularly valuable to mixed-breed feline owners or caretakers (both professional and non-professional) for the purpose of proactively considering health risks for individual tested animals.
  • a mixed breed cat that is found to be a mixture of a breed with known association or predisposition for certain disease conditions could be proactively monitored for such disease conditions that occur with rare frequency in the general population of cats, but occur with significant frequency in these specific breeds.
  • Health-related information may also include potential treatments, special diets or products, diagnostic information, and insurance information.
  • the invention provides one or more computer-readable media comprising a data structure stored thereon for use in distinguishing feline
  • the data structure comprises: a marker field, which is capable of storing the name of a marker (for example, an SNP marker) or the name of an allele of a marker; and a genotype information field, which is capable of storing genotype information for the marker (for example, the identity of one or both alleles of the marker in a feline genome or an estimate of the frequency of an allele of the marker in a feline population), wherein a record comprises an instantiation of the marker field and an instantiation of the genotype information field and a set of records represents a feline population profile.
  • a marker field which is capable of storing the name of a marker (for example, an SNP marker) or the name of an allele of a marker
  • a genotype information field which is capable of storing genotype information for the marker (for example, the identity of one or both alleles of the marker in a feline genome or an estimate of the frequency of an allele of the marker in a feline population)
  • a "computer-readable medium” refers to any available medium that can be accessed by computer and includes both volatile and nonvolatile media, removable and nonremovable media. Computer readable media that are non-transitory find use.
  • computer-readable media may comprise computer storage media and communication media.
  • Computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information, such as computer-readable instructions, data structures, program modules, or other data.
  • Computer storage media include, but are not limited to, RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital versatile disks (DVD) or other optical disk storage, magnetic cassettes, magnetic tapes, magnetic disk storage or other magnetic storage devices, or any other computer storage media.
  • Communication media typically embody computer-readable instructions, data structures, program modules or other data in a modulated data signal, such as a carrier wave or other transport mechanism that includes any information delivery media.
  • modulated data signal means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal.
  • communication media include wired media, such as a wired network or direct- wired connection, and wireless media, such as acoustic, RF infrared, and other wireless media.
  • wired media such as a wired network or direct- wired connection
  • wireless media such as acoustic, RF infrared, and other wireless media.
  • a "data structure” refers to a conceptual arrangement of data and is typically characterized by rows and columns, with data occupying or potentially occupying each cell formed by a row-column intersection.
  • a data structure in the computer-readable medium can comprise a marker field and a genotype information field, as described above. The instantiation of the marker field and the genotype information field provides a record, and a set of record provides a feline population profile.
  • the data structure may be used to create a database of feline population profiles.
  • the computer readable medium comprises a substrate having stored thereon: (a) a data structure for use in distinguishing feline populations, the data structure comprising: (i) a marker field, which is capable of storing the name of a marker or of an allele of a marker; and (ii) a genotype information field, which is capable of storing genotype information for the marker, wherein a record comprises an instantiation of the marker field and an instantiation of the frequency field and a set of records represents a feline population profile; and (b) computer-executable instructions for implementing a method for determining the contributions of feline populations to a feline genome, comprising: (i) obtaining the identity of one or both alleles in a test feline genome for each marker of a set of markers; and (ii) determining the contributions of feline populations to the test feline genome by comparing the alleles in the test feline genome to a database comprising feline population profiles, wherein each feline population profile comprises genotyp
  • the invention provides nucleic acid sequences for determining the identity of one or both alleles in a feline genome for each marker of a set of markers, e.g., as listed in Table 1.
  • the nucleic acid sequences can be primer sets.
  • the primer sets are provided in a kit.
  • kits useful for determining the population of origin ⁇ e.g., ancestral lineage and/or breed contributions) of a feline comprise one or more oligonucleotide primer pairs as described herein suitable to amplify the portions of a feline genome comprising a plurality of the SNPs listed in Table 1.
  • the kit comprises oligonucleotide primer pairs for determining all 148 SNPs listed in Table 1.
  • the kits may further comprise one or more oligonucleotide primer pairs for determining one or more biomarkers listed in Table 3, e.g., for determining the SNPs in one or more of SEQ ID NOs: 149-202.
  • kits comprise forward and reverse primers suitable for amplification of a genomic DNA sample taken from a feline.
  • the biological sample can be from any tissue or fluid in which genomic DNA is present.
  • the sample may be taken from blood, skin ⁇ e.g., cheek swab) or a hair bulb.

Abstract

This invention provides genetic markers for use in identifying and assigning the population of origin of a feline.

Description

GENETIC IDENTIFICATION OF DOMESTIC CAT BREEDS AND
POPULATIONS
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit under 35 U.S. C. § 119(e) of
U.S. Provisional Application No. 61/487,987, filed on May 19, 2011, which is hereby incorporated herein in its entirety for all purposes.
STATEMENT OF GOVERNMENTAL SUPPORT
[0002] This invention was made with government support under Grant No.
R24 RROO 16094 awarded by the National Institutes of Health, National Center for Research Resources (NCRR). The government has certain rights in the invention.
FIELD OF THE INVENTION
[0003] The invention relates to determining the contribution of one or more feline populations to the genome of a feline using a predetermined set of genetic markers, including single nucleotide polymorphisms (SNPs), short tandem repeats (STRs) and DNA- based phenotypic markers.
BACKGROUND OF THE INVENTION
[0004] The domestication of the cat has been a slow and prolonged process, especially when compared to most species associated with human agricultural development. Indeed, the cat is often considered to be only semi-domesticated. Archaeological remains of cats in close proximity to and even buried alongside humans suggest that cats were first domesticated in Cyprus during the Neolithic age 5,000-10,000 BP (Vigne et al, (2004) Science 304, 259-259.) but popular culture suggests cats were domesticated in Egypt (Malek, (1993) The cat in ancient Egypt British Museum Pr. for the Trustees of the British Museum, London; Nowell, (1996) Status Survey and Conservation Action Plan: Wild Cats IUCN, Gland, Switzerland.). Genetic studies using STR and mtDNA analysis of feral and wildcats from throughout Africa and Eurasia identified the Near Eastern Arabian/Northern African wildcat subspecies (Felis silvestris libyca) as the species most closely related to the domestic cat (Driscoll et al., (2007) Science 317, 519-523). Other early human civilizations developed near the Yellow River region of China and the Indus Valley of present day Pakistan. However, sufficient sampling or documentation of wildcats in these regions is inadequate. Only the Fertile Crescent lies within the range of F. s. lybica, which has better documentation and sampling. In addition to the wildcat studies, an independent STR study of both feral and pedigreed cats found the highest genetic diversity of the sampled cats in the region of the eastern Mediterranean Sea, supporting a Fertile Crescent origin of cat domestication (Lipinski et al, (2008) Genomics 91, 12-21.). However, neither study sampled the cats of the Fertile Crescent and Egypt sufficiently to closely examine cat populations in this historically important region, which is necessary for pinpointing the site of cat domestication.
[0005] Genetic markers that arise through a variety of mutational mechanisms help to resolve population stratifications and trace historical migrations (Zeder et al., (2006) Trends in Genetics 22:139-155). STRs and have long been the preferred tool for genetic analyses of recently diverged populations, such as cat breeds, due to their high mutation rate and relative cost effectiveness in comparison to sequencing techniques (Brown et al, (1979) Proc. Natl. Acad. Sci. USA 76: 1967-1971). Analysis of different areas of the mtDNA, particularly gene sequences provide evidence of the matrilineal history of the domesticated cat and of the closest common ancestor, the African wildcat from the Near East (Driscoll et al., 2007, supra). In addition, the mtDNA control region (CR), with its fast rate of mutation, provides evidence of recent admixture of most of the worldwide cat populations (Grahn et al, Forensic Sci Int Genet. (2011) 1 :33-42). The advent of high-throughput SNP typing platforms allows the genotyping of many markers with slower mutation rates, rates which can help define a population's more ancient origins and provide finer-scale evidence for the first domesticated cat populations. Thus, genetic analysis of the same cat populations, using an assortment of DNA markers with a variety of mutation patterns, will better define cat population stratification but not obfuscate the more ancient lineages, further clarifying the domestication progression from ancient to modern cats.
[0006] Data presented herein shows that the domestic cat origins lie within the
Northern region of the Fertile Crescent, where the earliest agriculture and civilizations began. Random bred domestic cat populations from around the world, specifically the region of the Fertile Crescent and Egypt, were genetically investigated to improve the resolution of cat population structures within this important site of cat domestication. Two types of genetic markers, STRs and SNPs, were genotyped in the same cat populations, including several larger populations from the Fertile Crescent region. [0007] The genetic markers further find application in determining the breed pedigree or population origins of a subject feline. Over the past 125 years, mankind has imposed artificial selection to further the previously unchecked process of cat domestication resulting in pedigreed cats. Since the first USA cat show in 1895, which presented five breeds, the development of pedigreed cats has increased in popularity (Gebhardt (1991) The Complete Cat Book. Howell Book House, New York.). Forty-one breeds are currently recognized for competition by the Cat Fanciers' Association (CFA, on the internet at cfa.org/) and 57 are accepted by The International Cat Association (TICA, on the internet at tica.org/). A majority of the breeds recognized by these two large registries is also recognized around the world. A common, sometimes obsessive hobby of cat breeders is feline genealogy, or tracing the true genetic ancestry of the breed and even of one's own random bred pet cat. Many commercial service laboratories are marketing genetic tests for dogs, promising the elucidation of "the breed ancestry of your best friend". Random bred house cats, however, have a different story to their genetic origins. Whereas the average feline mutt found in the streets of most developed countries is more likely a cross-bred individual from multiple purebred breeds, the average random bred cat is not a descendant of their pedigreed counterparts. For cats, the opposite scenario is more likely - pedigreed feline stocks are the descendants of common street cats from distinct parts of the world that have been selected for a distinctive trait (Table 8) (CFA (1993) The Cat Fanciers'
Association Cat Encyclopedia, Simon & Schuster, New York). Random bred cats are the original populations from which the breeds developed, not a population of pedigreed cats gone feral. In addition, also converse to most dog registries, to improve population health and reduce the effects of inbreeding depression, cat breeding associations often seek to diversify their breed populations with random bred cats from their ancestral origin. For this reason, most cat registries use the term "pedigreed" and not "purebred".
[0008] Two studies have evaluated the genetic distinction of cat breeds. Lipinski et al. ((2008) Genomics, 91 : 12-21) defined the connections between the random bred cat populations and their descendant pedigreed lines using a DNA marker panel containing two tetranucleotide and 36 dinucleotide STR markers. Five hundred fifty-five individuals were demarcated into 20 breeds. Four breeds could not be resolved at the breed level.
Furthermore, the breeds sampled by Lipinski et al. were shown to be similar to the populations of street cats found in Europe, the Eastern Mediterranean and Southeast Asia. Menotti-Raymond et al. ((2008) Genomics, 91 :1-11) used a panel of eleven tetranucleotide STR markers and ten regions of SNPs in a subset of their sample set in order to characterize the delineation of cat breeds. Further attempts at population division caused lineages within breeds to resolve before that of the recognized sister breeds. Using only the STR markers, 1040 individuals were demarcated into 8 individual breeds and 9 additional breed groups. Twenty breeds could not be resolved at the breed level. These studies indicated that distinct populations and breeds of cats can be defined genetically, that breeds do have different worldwide regions of origin, tetranucleotide STRs do not perform as well with defining cat breeds as the dinucleotide markers, and that some breeds are so closely related that they cannot be distinguished with even the rapidly evolving dinucleotide STRs.
[0009] The 38 highly polymorphic markers of Lipinski et al. (2008), supra, and a recently developed panel of 148 intergenic autosomal SNPs were recently applied to an extensive sample of random bred street cats collected throughout the world (described herein). Nine hundred forty-four samples were collected from 37 locations spread throughout North and South America, Europe, Africa, and Asia. This study found that while both were efficient at distinguishing five long established lineages, a few
geographically close populations were better delineated with either SNPs or STRs, most likely due to varying mutation rates between the markers.
[0010] Many methods of assignment testing have been developed in the past decade using common population genetic markers and a variety of statistical methods (Rannala & Mountain (1997) Proc Natl Acad Sci USA. 94(17):9197-9201; Pritchard et al. (2000) Genetics, 155:945-959; Baudouin & Lebrun (2001) In: Proc. Int. Symp. on Molecular Markers, pp. 81-94; Paetkau et al. (2004) Molecular Ecology, 13:55-65). These methods have been applied to various breeding populations including pigs, cattle, and dogs
(Schelling et al. (2005) Journal of Animal Breeding and Genetics, 122:71-77; Negrini et al. (2009) Animal Genetics, 40: 18-26; Boitard et al. (2010) Anim Genet. 2010 41(6):608-18. In cattle, Negrini et al. (2009), supra, used 90 SNPs to both allocate and then assign 24 breeds under both the Baysean methods of Pritchard et al. (2000), supra, and Rannala & Mountain (1997), supra, and Baudouin & Lebrun (2001), supra, and the likelihood method of Paetkau et al. (2004), supra. Negrini et al. (2009) concluded that the methods implemented through Rannala & Mountain (Bayesian) (1997) and Petkau et al.
(frequentist) (2004) worked best when attempting to assign unknown individuals to a known database of representative samples from each breed. Previous population studies used Bayesian clustering and neighbor-joining phylogenetic analyses to elucidate the cat breeds and the origins of random bred populations. The present invention demonstrates the utility of a panel of 148 evenly dispersed genome-wide SNPs for population assignment of cats. Different assignment techniques are examined and demonstrated in a species exhibiting many recent and extreme population bottlenecks, comparing the power and efficiency of this 148 SNP panel to 4-fold fewer microsatellites. The power of phenotypic DNA variants is demonstrated for sensitivity and specificity to support individual assignment, specifically for closely related cat breeds that are demarcated by single gene traits.
SUMMARY OF THE INVENTION
[0011] The present invention provides genetic markers useful for the determination of the the population of origin (e.g., ancestral lineage and/or contributing breed(s)) of a test feline. Accordingly, in one aspect, the invention provides computer implemented methods for determining the contributions of feline populations to a feline genome. In some embodiments, the methods comprise:
(a) genotyping a sample comprising genomic DNA obtained from a test feline to determine the identity of one or both alleles of each marker of a set of markers, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ;
(b) comparing the identity of one or both alleles for each of the markers in the set of markers determined to be present in the test feline genome to a database comprising one or more feline population profiles, wherein each feline population profile comprises genotype information for the set of markers in the feline population; and
(c) determining the contribution of the one or more feline populations to the test feline genome.
[0012] In a further aspect, the invention provides methods for defining one or more feline populations. In some embodiments, the methods comprise:
(a) determining the identity of one or both alleles for each marker of a set of markers in a test feline genome, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
(b) applying a computer-implemented statistical model to define one or more distinct feline populations, wherein one or more distinct feline populations are characterized by a set of allele frequencies for each marker of the set of markers comprising a plurality of
SNPs listed in Table 1. [0013] In a related aspect, the invention provides methods for determining the contributions of feline populations to a feline genome. In some embodiments, the methods comprise performing a genotyping assay on a sample comprising genomic DNA obtained from a test feline to determine the identity of one or both alleles present in the test feline genome for each marker of a set of markers, wherein the set of markers is indicative of the contribution of feline populations to the genome of the test feline, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1.
[0014] In another aspect, the invention provides methods of assigning a feline individual to a population of origin (e.g., an ancestral lineage and/or one or more contributing breeds), which comprises:
(a) genotyping the feline individual to identify one or both alleles of each marker of a set of markers to thereby identify the individual's genotype, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ;
(b) applying a computer-implemented statistical model to assign the feline individual to one or more feline populations in a database, wherein the one or more feline populations are characterized by a set of allele frequencies for each marker of the set of markers; and
(c) assigning the feline individual to the one or more most likely populations identified in step (b). In some embodiments, the individual is assigned to the one or more most likely feline populations if the population genotype probability for the most likely feline populations exceeds the value of assignment to any other feline populations of the database.
[0015] With respect to the embodiments, in some embodiments, the plurality of
SNPs comprises at least about 5 SNPs listed in Table 1, for example, at least about 10, 15, 20, 25, 30, 40, 50, 60, 70, 75, 80, 90, 100, 110, 120, 125, 130, 140 or 148 SNPs listed in Table 1. The SNPs listed in Table 1 are as depicted at position 61 of a polynucleotide selected from the group consisting of SEQ ID NO: l to SEQ ID NO: 148 listed in Table 1. In some embodiments, the plurality of SNPs comprises all 148 SNPs listed in Table 1, e.g., as depicted at position 61 of polynucleotides SEQ ID NO: l to SEQ ID NO: 148 listed in Table 1.
[0016] For example, the plurality of SNPs listed in Table 1 are as depicted at position 61 of a polynucleotide selected from the group consisting of SEQ ID NO: l to SEQ ID NO: 148. In some embodiments, the set of markers comprises a plurality of SNPs, wherein the SNPs are selected from the group consisting of position 61 of SEQ ID NO: l, position 61 of SEQ ID NO:2, position 61 of SEQ ID NO:3, position 61 of SEQ ID NO:4, position 61 of SEQ ID NO:5, position 61 of SEQ ID NO:6, position 61 of SEQ ID NO:7, position 61 of SEQ ID NO:8, position 61 of SEQ ID NO:9, position 61 of SEQ ID NO:10, position 61 of SEQ ID NO: 11, position 61 of SEQ ID NO: 12, position 61 of SEQ ID
NO: 13, position 61 of SEQ ID NO: 14, position 61 of SEQ ID NO: 15, position 61 of SEQ ID NO: 16, position 61 of SEQ ID NO: 17, position 61 of SEQ ID NO: 18, position 61 of SEQ ID NO: 19, position 61 of SEQ ID NO:20, position 61 of SEQ ID NO:21, position 61 of SEQ ID NO:22, position 61 of SEQ ID NO:23, position 61 of SEQ ID NO:24, position 61 of SEQ ID NO :25, position 61 of SEQ ID NO :26, position 61 of SEQ ID NO :27, position 61 of SEQ ID NO:28, position 61 of SEQ ID NO:29, position 61 of SEQ ID NO:30, position 61 of SEQ ID NO:31, position 61 of SEQ ID NO:32, position 61 of SEQ ID NO:33, position 61 of SEQ ID NO:34, position 61 of SEQ ID NO:35, position 61 of SEQ ID NO:36, position 61 of SEQ ID NO:37, position 61 of SEQ ID NO:38, position 61 of SEQ ID NO:39, position 61 of SEQ ID NO:40, position 61 of SEQ ID NO:41, position 61 of SEQ ID NO:42, position 61 of SEQ ID NO:43, position 61 of SEQ ID NO:44, position 61 of SEQ ID NO:45, position 61 of SEQ ID NO:46, position 61 of SEQ ID NO:47, position 61 of SEQ ID NO:48, position 61 of SEQ ID NO:49, position 61 of SEQ ID NO:50, position 61 of SEQ ID NO:51, position 61 of SEQ ID NO:52, position 61 of SEQ ID NO:53, position 61 of SEQ ID NO:54, position 61 of SEQ ID NO:55, position 61 of SEQ ID NO:56, position 61 of SEQ ID NO:57, position 61 of SEQ ID NO:58, position 61 of SEQ ID NO:59, position 61 of SEQ ID NO:60, position 61 of SEQ ID NO:61, position 61 of SEQ ID NO:62, position 61 of SEQ ID NO:63, position 61 of SEQ ID NO:64, position 61 of SEQ ID NO:65, position 61 of SEQ ID NO:66, position 61 of SEQ ID NO:67, position 61 of SEQ ID NO:68, position 61 of SEQ ID NO:69, position 61 of SEQ ID NO:70, position 61 of SEQ ID NO:71, position 61 of SEQ ID NO:72, position 61 of SEQ ID NO:73, position 61 of SEQ ID NO:74, position 61 of SEQ ID NO:75, position 61 of SEQ ID NO:76, position 61 of SEQ ID NO:77, position 61 of SEQ ID NO:78, position 61 of SEQ ID NO:79, position 61 of SEQ ID NO:80, position 61 of SEQ ID NO:81, position 61 of SEQ ID NO:82, position 61 of SEQ ID NO:83, position 61 of SEQ ID NO: 84, position 61 of SEQ ID NO: 85, position 61 of SEQ ID NO: 86, position 61 of SEQ ID NO:87, position 61 of SEQ ID NO:88, position 61 of SEQ ID NO:89, position 61 of SEQ ID NO:90, position 61 of SEQ ID NO:91, position 61 of SEQ ID NO:92, position 61 of SEQ ID NO:93, position 61 of SEQ ID NO:94, position 61 of SEQ ID NO:95, position 61 of SEQ ID NO:96, position 61 of SEQ ID NO:97, position 61 of SEQ ID NO:98, position 61 of SEQ ID NO:99, position 61 of SEQ ID NO: 100, position 61 of SEQ ID NO: 101, position 61 of SEQ ID NO: 102, position 61 of SEQ ID NO: 103, position 61 of SEQ ID NO: 104, position 61 of SEQ ID NO: 105, position 61 of SEQ ID NO: 106, position 61 of SEQ ID NO: 107, position 61 of SEQ ID NO: 108, position 61 of SEQ ID NO: 109, position 61 of SEQ ID NO: 110, position 61 of SEQ ID NO: 111, position 61 of SEQ ID NO: 112, position 61 of SEQ ID NO: 113, position 61 of SEQ ID NO: 114, position 61 of SEQ ID NO: 115, position 61 of SEQ ID NO: 116, position 61 of SEQ ID NO: 117, position 61 of SEQ ID NO : 118, position 61 of SEQ ID NO : 119, position 61 of SEQ ID NO : 120, position 61 of SEQ ID NO: 121, position 61 of SEQ ID NO: 122, position 61 of SEQ ID NO: 123, position 61 of SEQ ID NO: 124, position 61 of SEQ ID NO: 125, position 61 of SEQ ID NO: 126, position 61 of SEQ ID NO: 127, position 61 of SEQ ID NO: 128, position 61 of SEQ ID NO : 129, position 61 of SEQ ID NO : 130, position 61 of SEQ ID NO : 131 , position 61 of SEQ ID NO:132, position 61 of SEQ ID NO: 133, position 61 of SEQ ID NO: 134, position 61 of SEQ ID NO: 135, position 61 of SEQ ID NO: 136, position 61 of SEQ ID NO: 137, position 61 of SEQ ID NO: 138, position 61 of SEQ ID NO: 139, position 61 of SEQ ID NO: 140, position 61 of SEQ ID NO: 141, position 61 of SEQ ID NO: 142, position 61 of SEQ ID NO: 143, position 61 of SEQ ID NO: 144, position 61 of SEQ ID NO: 145, position 61 of SEQ ID NO: 146, position 61 of SEQ ID NO: 147, and position 61 of SEQ ID NO: 148.
[0017] In some embodiments, the set of markers comprises a plurality of SNPs, wherein the SNPs are selected from the group consisting of chrAl_10141047,
chrAl l 33621071, chrAl l 51648701, chrAl_175780586, chrAl_208054462,
chrAl_223501140, chrAl_223506906, chrAl_225057933, chrAl_235579538,
chrAl_27523501, chrAl_68485376, chrAl_69424718, chrAl_7429296, chrAl_8742286, chrA2_152258936, chrA2_201526186, chrA2_202225770, chrA2_44241149,
chrA2_554046, chrA3_101420069, chrA3_l 1480952, chrA3_12082294,
chrA3_l 30195244, chrA3_159537633, chrA3_l 62208567, chrA3_38781591,
chrA3_75156179, chrA3_91058022, chrA3_99507784, chrBl l 0420438,
chrBl_12214271, chrBl_195678303, chrB 1 199564532, chrBl_202966562,
chrBl_54775572, chrBl_80161671, chrBl_88148379, chrB2_138312489,
chrB2_146660650, chrB2_41509834, chrB2_45093345, chrB2_6949528,
chrB3_l 04483970, chrB3_l 11000326, chrB3_l 3666494, chrB3_39203469, chrB3_51317931, chrB3_57141954, chrB3_77094074, chrB4_l 05706694, chrB4_142658074, chrB4_143006494, chrB4_144693308, chrB4_146486983,
chrB4_147206961, chrB4_149532846, chrB4_1687419, chrB4_20001848,
chrB4_21098349, chrB4_255106, chrB4_3093827, chrB4_40319102, chrB4_47638578, chrCl_l 16355295, chrCl_123164748, chrCl_l 81852965, chrCl_190502133,
chrCl_215441574, chrCl_216852686, chrCl_24148281, chrCl_28702055,
chrCl_34981315, chrCl_396397, chrCl_44520932, chrCl_52456776, chrC2_106991233, chrC2_147124460, chrC2_l 50774106, chrC2_156491175, chrC2_187325, chrC2_262401, chrC2_5215469, chrDl_101321498, chrD 1 104941557, chrD 1 105498119,
chrDl_10789012, chrDl l 1484008, chrD 1 117527468, chrDl_125811329,
chrDl_126256993, chrDl_126847301, chrD 1_15984279, chrD 1_16242433,
chrDl_18390852, chrDl_18570323, chrD 1 66177762, chrD2_l 020904,
chrD2_l 05772916, chrD2_l 752007, chrD2_56777338, chrD2_717969, chrD2_74293444, chrD2_91989307, chrD3_103840114, chrD3_122502120, chrD3_1810839,
chrD3_24565823, chrD3_24823793, chrD3_28838660, chrD4_41078218,
chrD4_42000379, chrD4_63622083, chrEl_130875919, chrEl_131587399,
chrEl_3912105, chrEl_4114158, chrEl_48228153, chrEl_48700963, chrEl_5453028, chrE2_22632289, chrE2_34027888, chrE2_35914023, chrE2_36986631, chrE2_38860686, chrE2_39211557, chrE2_65436639, chrE2_7950477, chrE2_8422942, chrE3_36044809, chrE3_55434272, chrE3_67006512, chrFl_20309325, chrF 1 21799641, chrFl_26100599, chrFl_27124984, chrFl_38051725, chrFl_565223, chrFl_82068276, chrFl_82716202, chrFl_91517402, chrF2_26886470, chrF2_38395360, chrF2_46855978, chrF2_68572596, chrF2_74863327, chrF2_78303221, chrF2_79632602 and chrF2_8427817.
[0018] In some embodiments, the set of markers further comprises one or more microsatellite markers. For example, in some embodiments, the set of markers further comprises one or more STRs selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
[0019] In various embodiments, prior to or in addition to genotyping, a most likely population of origin is based on one or more morphological features of the test feline. In some embodiments, prior to or in addition to genotyping, one or more morphological features of the test feline allow the exclusion of one or more of the candidate populations of origin. For example, the feline may be evaluated for coat color (e.g. , chocolate, cinnamon, dilute, orange, white), coat patterning (e.g., agouti, tabby, spotted, ticked, calico, point coloring), coat texture (e.g., straight or rex), coat length (e.g., hairless, short or long), ear morphology (e.g. , normal, curled or folded), paw morphology (e.g. , normal or polydactyl), and tail morphology (e.g., manx, bobtail, long).
[0020] In some embodiments, the set of markers further comprises one or more phenotypic markers. For example, in some embodiments, the set of markers further comprises one or more of the phenotypic markers selected from the group consisting of Phen CM AH G 139 A, Phen ASIP del, Phen_MLPH_T83del, Phen_MClR_G250A, Phen_TYRPl_C298T, Phen_TYRPl_5IVS6, Phen_TYR_del975C, Phen_TYR_G715T, Phen_TYR_G940A, Phen_KIT_G1035C_BI, Phen_FGF5_475, Phen_FGF5_474, phen_FGF5_406, Phen_FGF5_356, Phen_GBLl_G1457C_SIA_KOR,
Phen HEXB Dellntr BUR, Phen_HEXB_del39C_KOR, Phen GBE 1 Ins NFC ,
Phen_KRT71_G/Aintro4_SPX, Phen_MYBPC_G93C_MCC,
Phen_MYBPC_C2460T_RAG, phen MPO ALC, Phen PLAU AG ALC,
Phen FC AT ALC , Phen_PKLR_13delE6_Aby, Phen_PKDl_C10063A_PER,
Phen_SHH_A479G_Hw, Phen_CEP290_PRA_Aby, Phen_CRX_546_Aby,
Phen CMAH del, Phen_HEXB_C667T_DSH, Phen_GM2A_Del_DSH,
Phen GRHPR DSH, Phen LPL G 1234A DSH, Phen LAMAN del PER,
Phen lDUA del DSH, Phen_ARSB_G1558A_SIA, Phen_ARSB_T1427C_Sia,
Phen GUSB Al 052G DSH, Phen_MYBPC_A74T_Poly, Phen NPC 1 G2864C PER, Phen_SHH_G257C_UKl , Phen_SHH_A481T_UK2, Phen_HMBS_del842_SIA, Phen- HMBS l 89TT SIA, Phen_CYP21Bl , Phen TAS 1 R2 CAT,
Phen_TASlR2_G8224A_CAT, Phen_CYP27Bl_Rob, Phen ZFX, KRT71 -Del Drex,
P2RY5_CRex, WNK4_Burm_HKL, and CARTl del Burm. In some embodiments, the set of markers further comprises one or more of the phenotypic markers selected from the group consisting of SEQ ID NO: 149 to SEQ ID NO:202, shown in Table 3.
[0021] In some embodiments, the marker locus genotypes for each candidate population are in Hardy- Weinberg Equilibrium and/or Gametic Phase Equilibrium.
[0022] In various embodiments, the genotype information in each feline population profile comprises identities of one or both alleles of each marker of the set of markers. In some embodiments, the genotype information in each feline population profile comprises allele frequencies for one or both alleles of each marker of the set of markers. In various embodiments, the genotype information in each feline population profile comprises both the identities and the allele frequencies of one or both alleles of each marker of the set of markers.
[0023] In some embodiments, the database of feline population profiles comprises one or more feline population profiles. In various embodiments, the database of feline population profiles comprises a plurality of feline population profiles, for example, between about 5 and about 500 feline population profiles, for example, about 10-400, 15-300, or 20-200 feline population profiles, for example, about 5, 10, 15, 20, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, or more, feline population profiles.
[0024] In some embodiments, the database of feline populations profiles comprise one or more profiles of feline ancestral lineages, i.e., randombred populations of origin. For example, the feline populations profiles may comprise the profiles of one or more ancestral lineages of random bred worldwide populations of cats, including, e.g., Europe,
Mediterranean, Egypt, Iraq/Iran, Arabian Sea, India, Southeast Asia, and East Asia. In some embodiments, the feline populations profiles may comprise the profiles of 1, 2, 3, 4, 5, 6, 7, 8, or more, ancestral lineages of random bred worldwide populations of cats.
[0025] In some embodiments, the database of feline populations profiles comprise profiles of one or more feline breeds. Breeds of interest are recognized by at least one cat breed registry. For example, the breed may be recognized by one or more cat registries selected from the group consisting of The International Cat Association (TICA); the Cat Fanciers' Association (CFA); The Australian Cat Federation (ACF); Co-Ordinating Cat Council of Australia (CCC of A); Federation Internationale Feline (FIFe); Governing Council of the Cat Fancy (GCCF); The New Zealand Cat Fancy (NZCF); The Southern African Cat Council (SACC); The World Cat Federation (WCF); American Cat Fanciers Association (ACFA); The Traditional Cat Association, Inc. (TCA); International
Progressive Cat Breeders' Alliance (IPCBA); Canadian Cat Association (CCA); Cat Fanciers' Federation (CFF); American Association of Cat Enthusiasts (AACE); Australian National Cats (WNCA); Capital Cats Incorporated (CCI); Catz Incorporated; Council of Federated Cat Clubs of Qld (CFCCQ); The Feline Association of NSW (TFA of NSW); Feline Control Council (FCC); Gold Coast Cat Club; The Governing Council of the Cat Fancy of South Australia (GCCFSA); NSW Cat Fanciers* Association (NSW CFA;);
Queensland Feline Association (QFA); Queensland Independent Cat Council (QICC;); Hong Kong Cat Lovers' Society; Korea Cat Club (KOCC); The Cat Federation of Southern Africa (CFSA); The Asian Cat Association (ACA); Bavarian Cat Fanciers' Association; and Feline Federation Europe.
[0026] In various embodiments, the database comprises profiles of a plurality of feline breeds, for example, profiles of at least about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more, feline breeds recognized by one or more cat registries. For example, in certain embodiments, the profiles of feline breeds are selected from the group consisting of Persian, Exotic Shorthair (SH), British SH, Scottish Fold, Chartreux, American SH, Sphynx, Japanese Bobtail, Cornish Rex, Ragdoll, Maine Coon, Abyssinian, Siberian, Norwegian FC, Manx, Egyptian Mau, Turkish Angora, Turkish Van, Bengal, Sokoke, Ocicat, Russian Blue, Australian Mist, Burmese, Birman, Havana Brown, Korat, Siamese and Singapura. In some embodiments, the profiles of feline breeds are selected from the group consisting of Abyssinian, American Bobtail, American Bobtail Shorthair (SH), American Curl, American Curl Longhair (LH), American Shorthair, American Wirehair, Balinese, Bengal, Birman, Bombay, British Shorthair, British Longhair, Burmese, Chartreux, Colorpoint Shorthair, Cornish Rex, Cymric, Devon Rex, Don-Skoy, Egyptian Mau, European Burmese, Exotic Shorthair, Havana Brown, Himalayan, Japanese Bobtail, Japanese Bobtail Longhair, Korat, LaPerm, Maine Coon, Manx, Munchkin, Munchkin Longhair, Nebelung, Norwegian Forest Cat, Ocicat, Oriental Longhair, Oriental Shorthair, Persian, Peterbald, Pixiebob, Pixiebob Longhair, RagaMuffm, Ragdoll, Russian Blue, Scottish Fold, Scottish Fold Longhair, Selkirk Rex, Selkirk Rex Longhair, Siamese, Siberian, Singapura, Snowshoe, Somali, Sphynx, Thai, Tonkinese, Toyger, Turkish Angora, and Turkish Van. The profiles of feline breeds may also include one or more of Chausie, Savannah, Bambino, Donskey,
Highlander, Highlander Shorthair, Kurilian Bobtail, Kurilian Bobtail Longhair, Minskin, Ojos Azules, Ojos Azules Longhair, Serengeti and Sokoke.
[0027] In various embodiments, the test feline is suspected of having genetic contributions of 4 or fewer breeds. For example, a test feline may be suspected of being a purebred, having a genetic composition primarily contributed from a single breed, having a genetic composition primarily contributed by two distinct breeds, having a genetic composition primarily contributed by three distinct breeds, or having a genetic composition primarily contributed by four distinct breeds.
[0028] In some embodiments, the set of markers comprises a subset of the 148 SNP markers listed in Table 1 and the method determines the contributions of one or more feline populations to the test feline genome. In various embodiments, the set of markers comprises fewer than about 150 SNP markers and the method determines the contributions of 1, 2, 3 or 4 feline populations to the test feline genome.
[0029] The identity of one or both alleles of a marker can be determined using any method in the art. In some embodiments, the identity of one or both alleles of a marker is determined by amplifying genomic DNA of the test feline using primers specific for each of the set of markers and determining the size of the amplification product. In some embodiments, the identity of one or both alleles of a marker is determined by amplifying genomic DNA of the test feline using primers specific for each of the set of markers and sequencing the amplification product.
[0030] In some embodiments, the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises a genotype clustering program. In some embodiments, the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises an assignment program. In some embodiments, the algorithm used to compare the identity of one or both alleles for each of the markers in the set of markers to a database comprising the one or more, or a plurality, of feline population profiles comprises both a genotype clustering program and an assignment program. In some embodiments, the clustering program is a Bayesian clustering program. In some embodiments, the assignment program is a likelihood or frequentist program. In some embodiments, the test feline is assigned to the most likely population of origin if the population genotype probability for the most likely population of origin exceeds the value of assignment to any other population of the database.
[0031] In some embodiments, the contributions of two or more genetically related feline populations to the test feline genome are discriminated by comparing the alleles in the test feline genome to a database comprising profiles of the two or more genetically related feline populations. For example, in various embodiments, the two or more genetically related feline populations being discriminated are selected from the group consisting of (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese; (iv) Singapura and Burmese; (v) Birman and Korat, and (vi) Siamese and Havana Brown. As appropriate, one or more phenotypic markers can be determined, in addition to determining the identity of a plurality of the SNPs listed in Table 1 , to help distinguish between the contributions of two or more genetically related feline populations to the test feline genome.
[0032] For example, the genotype of the FGF5 SNP, which causes long hair, can be determined to affirmatively assign a test feline to one or more breeds selected from the group consisting of Persian, Maine Coon, Turkish Angora, Turkish Van and Birman.
Similarly, a FGF5 genotype indicative of the presence of long hair can be used to exclude assignment to one or more breeds selected from the group consisting of Abyssinian, Egyptian Mau, Sokoke, Ocicat, and short-haired varieties of other recognized feline breeds. In some embodiments, the genotypes of one or both alleles of one or more of the FGF5 SNPs depicted by SEQ ID NOs: 159-162 are determined. In some embodiments, the genotypes of one or both alleles of all four of the FGF5 SNPs depicted by SEQ ID
NOs: 159-162 are determined.
[0033] In various embodiments, the methods further comprise reporting the results of the analysis. In some embodiments, the methods further comprise the step of providing a document displaying the contributions of one or more feline populations to the genome of the test feline genome. In various embodiments, the document provides additional information regarding the one or more feline populations that contributed to the genome of the test feline. In some embodiments, the document provides health-related information. In some embodiments, the document provides a certification of the contributions of one or more feline populations to the genome of the test feline. In some embodiments, the document provides a representation of the one or more feline populations that contributed to the genome of the test feline.
[0034] In another aspect, the invention provides one or more primer sets for determining the identity of one or both alleles a plurality of single nucleotide
polymorphisms (SNPs) listed in Table 1. In various embodiments, primer sets for determining the identity of one or both alleles of at least about 5 SNPs, for example, at least about 10, 15, 20, 25, 30, 40, 50, 60, 70, 75, 80, 90, 100, 110, 120, 125, 130, 140, 148 SNPs listed in Table 1 are provided. The primer sets may be provided in a kit.
[0035] In a related aspect, the invention provides one or more computer-readable media. In some embodiments, the computer-readable media comprise:
(a) a data structure stored thereon for use in distinguishing feline populations, the data structure comprising: (i) marker data, wherein the marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
(ii) genotype information data, wherein the genotype information data provides genotype information for each marker of a set of markers in a feline population, wherein a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile; and
(b) computer-executable instructions for controlling one or more computing devices to:
(i) identify one or both alleles in a test feline genome for each marker of the set of markers; and
(ii) determine the contributions of one or more feline populations to the test feline genome by comparing the identified alleles in the test feline genome to the database comprising one or more feline population profiles, wherein each feline population profile comprises genotype information for the set of markers in the feline population.
[0036] In a further aspect, the invention provides one or more computer-readable media comprising a data structure stored thereon for use in distinguishing feline
populations. In some embodiments, the data structure comprises:
(a) marker data, wherein the marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
(b) genotype information data, wherein the genotype information data provides genotype information for each marker of a set of markers in a feline population, wherein a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile.
[0037] Further embodiments in the computer readable media are as described above and herein. DEFINITIONS
[0038] Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Generally, the nomenclature used herein and the laboratory procedures in cell culture, molecular genetics, organic chemistry and nucleic acid chemistry and hybridization described below are those well known and commonly employed in the art. Standard techniques are used for nucleic acid and peptide synthesis. Generally, enzymatic reactions and purification steps are performed according to the manufacturer's specifications. The techniques and procedures are generally performed according to conventional methods in the art and various general references (see generally, Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL, 3rd ed.
(2001) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. and Ausubel, et al., Current Protocols in Molecular Biology, 1987-2011, John Wiley and Sons), which are provided throughout this document. The nomenclature used herein and the laboratory procedures in analytical chemistry, and organic synthetic described below are those well known and commonly employed in the art. Standard techniques, or modifications thereof, are used for chemical syntheses and chemical analyses.
[0039] The terms "isolated," "purified," or "biologically pure" refer to material that is substantially or essentially free from components that normally accompany it as found in its native state. Purity and homogeneity are typically determined using analytical chemistry techniques such as polyacrylamide gel electrophoresis or high performance liquid chromatography. Genomic DNA or a polynucleotide that is the predominant species present in a preparation is substantially purified. The term "purified" denotes that a nucleic acid gives rise to essentially one band in an electrophoretic gel. Particularly, it means that the nucleic acid or genomic DNA is at least 85% pure, more preferably at least 95% pure, and most preferably at least 99% pure.
[0040] The terms "nucleic acid" and "polynucleotide" are used interchangeably herein to refer to deoxyribonucleotides or ribonucleotides and polymers thereof in either single- or double-stranded form. The term encompasses nucleic acids containing known nucleotide analogs or modified backbone residues or linkages, which are synthetic, naturally occurring, and non-naturally occurring, which have similar binding properties as the reference nucleic acid, and which are metabolized in a manner similar to the reference nucleotides. Examples of such analogs include, without limitation, phosphorothioates, phosphoramidates, methyl phosphonates, chiral-methyl phosphonates, 2-O-methyl ribonucleotides, peptide-nucleic acids (PNAs). [0041] Unless otherwise indicated, a particular nucleic acid sequence also encompasses conservatively modified variants thereof (e.g., degenerate codon substitutions) and complementary sequences, as well as the sequence explicitly indicated. Specifically, degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is substituted with mixed-base and/or deoxyinosine residues (Batzer et al, Nucleic Acid Res. 19:5081 (1991); Ohtsuka et al, J. Biol. Chem. 260:2605 2608 (1985); Rossolini et al., Mol. Cell. Probes 8:91 98 (1994)). The term nucleic acid is used interchangeably with gene, cDNA, mRNA, oligonucleotide, and polynucleotide.
[0042] The terms "identical" or percent "identity," in the context of two or more nucleic acid sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of nucleotides that are the same (e.g., 80% identity, preferably 85%, 90%, 95%, 96%, 97%, 98%, 99% identity over a specified region such as the nucleic acid sequences of SEQ ID NOs: 1-148 and SEQ ID NOs: 149-202), when compared and aligned for maximum correspondence over a comparison window, or designated region as measured using a known sequence comparison algorithm (e.g. , BLAST, ALIGN) set to default settings or by manual alignment and visual inspection. Such sequences are then said to be "substantially identical." This definition also refers to the complement of a test sequence. Preferably, the identity exists over a region that is at least about 25 nucleotides in length, or more preferably over a region that is 50-100 nucleotides in length, or over the full length of the contextual sequence flanking the genetic marker.
[0043] A "label" or "detectable label" is a composition detectable by spectroscopic, photochemical, biochemical, immunochemical, or chemical means. For example, useful
3 35 32 51 125
labels include radioisotopes (e.g., H, S, P, Cr, or I) fluorescent dyes, electron-dense reagents, enzymes (e.g., alkaline phosphatase, horseradish peroxidase, or others commonly used in an ELISA), biotin, digoxigenin, or haptens and proteins for which antisera or monoclonal antibodies are available (e.g., the polypeptide comprising a sequence encoded by SEQ ID NO: l can be made detectable, e.g., by incorporating a radiolabel into the peptide, and used to detect antibodies specifically reactive with the peptide).
[0044] An "amplification reaction" refers to any chemical reaction, including an enzymatic reaction, which results in increased copies of a template nucleic acid sequence. Amplification reactions include polymerase chain reaction (PCR) and ligase chain reaction (LCR) (see U.S. Pat. Nos. 4,683,195 and 4,683,202; PCR Protocols: A Guide to Methods and Applications (Innis et al, eds, 1990)), strand displacement amplification (SDA) (Walker, et al. Nucleic Acids Res. 20(7): 1691 (1992); Walker PCR Methods Appl 3(1): 1 (1993)), transcription-mediated amplification (Phyffer, et al., J. Clin. Microbiol. 34:834 (1996); Vuorinen, et al, J. Clin. Microbiol. 33 : 1856 (1995)), nucleic acid sequence-based amplification (NASBA) (Compton, Nature 350(6313):91 (1991), rolling circle amplification (RCA) (Lisby, Mol. Biotechnol. 12(1):75 (1999)); Hatch et al., Genet. Anal. 15(2):35 (1999)) and branched DNA signal amplification (bDNA) (see, e.g., Iqbal et al, Mol. Cell Probes 13(4):315 (1999)).
[0045] "Amplifying" refers to submitting a solution to conditions sufficient to allow for amplification of a polynucleotide if all of the components of the reaction are intact.
Components of an amplification reaction include, e.g., primers, a polynucleotide template, polymerase, nucleotides, and the like. Thus, an amplifying step can occur without producing a product if, for example, primers are degraded.
[0046] "Amplification reagents" refer to reagents used in an amplification reaction. These reagents can include, e.g., oligonucleotide primers; borate, phosphate, carbonate, barbital, Tris, etc. based buffers (see, U.S. Pat. No. 5,508, 178); salts such as potassium or sodium chloride; magnesium; deoxynucleotide triphosphates (dNTPs); a nucleic acid polymerase such as Taq DNA polymerase; as well as DMSO; and stabilizing agents such as gelatin, bovine serum albumin, and non-ionic detergents (e.g. Tween-20). [0047] A "plurality" refers to two or more, for example, 2, 3, 4, 5, 10, 15, 20, 25, 30,
40, 50, 60, 70, 75, 80, 90, 100, 1 10, 120, 130, 140, 145, 148, 150, or more (e.g., genetic markers, including SNPs, short tandem repeats (STRs), microsatellites, phenotypic markers; feline population profiles). In some embodiments, a plurality refers to concurrent or sequential determination of about 2-150, 5-148, 50-148, 100-148 markers, for example, about 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 1 10, 120, 130, 140, 145, 148, 150, or more, markers. In some embodiments, "plurality" refers to all markers listed in one or more tables, e.g., all markers listed in Table 1 , and optionally also including all markers listed in Table 3.
[0048] A "single nucleotide polymorphism" or "SNP" refers to polynucleotide that differs from another polynucleotide by a single nucleotide exchange. For example, without limitation, exchanging one A for one C, G or T in the entire sequence of polynucleotide constitutes a SNP. Of course, it is possible to have more than one SNP in a particular polynucleotide. For example, at one locus in a polynucleotide, a C may be exchanged for a T, at another locus a G may be exchanged for an A and so on. When referring to SNPs, the polynucleotide is most often DNA and the SNP is one that usually results in a change in the genotype that is associated with a corresponding change in phenotype of the organism in which the SNP occurs. [0049] A "variant" is a difference in the nucleotide sequence among related polynucleotides. The difference may be the deletion of one or more nucleotides from the sequence of one polynucleotide compared to the sequence of a related polynucleotide, the addition of one or more nucleotides or the substitution of one nucleotide for another. The terms "mutation," "polymorphism" and "variant" are used interchangeably herein to describe such variants. As used herein, the term "variant" in the singular is to be construed to include multiple variances; i. e., two or more nucleotide additions, deletions and/or substitutions in the same polynucleotide. A "point mutation" refers to a single substitution of one nucleotide for another.
[0050] A nucleic acid "that distinguishes" as used herein refers to a
polynucleotide(s) that distinguishes a first polymorphism (e.g., a major allele of a SNP) from a second polymorphism (e.g. , a minor allele of the same SNP) at the same position in the genomic sequence. The nucleic acid that distinguishes can allow for polynucleotide extension and amplification after annealing to a polynucleotide comprising the first polymorphism, but will not allow for polynucleotide extension or amplification after annealing to a polynucleotide comprising the second polymorphism. In other embodiments, a nucleic acid that distinguishes a first polymorphism from a second polymorphism at the same position in the sequence will hybridize to a polynucleotide comprising the first polymorphism but will not hybridize to a polynucleotide comprising the second
polymorphism. The invention provides polynucleotides that distinguish the SNPs and genetic markers listed in Table 1.
[0051] The term "primer" refers to a nucleic acid sequence that primes the synthesis of a polynucleotide in an amplification reaction. Typically a primer comprises fewer than about 100 nucleotides and preferably comprises fewer than about 30 nucleotides.
Exemplary primers range from about 5 to about 25 nucleotides. The "integrity" of a primer refers to the ability of the primer to primer an amplification reaction. For example, the integrity of a primer is typically no longer intact after degradation of the primer sequences such as by endonuclease cleavage. [0052] The term "subsequence" refers to a sequence of nucleotides that are contiguous within a second sequence but does not include all of the nucleotides of the second sequence.
[0053] A "target" or "target sequence" refers to a single or double stranded polynucleotide sequence sought to be amplified in an amplification reaction. Two target sequences are different if they comprise non-identical polynucleotide sequences.
[0054] As used herein a "nucleic acid probe or oligonucleotide" is defined as a nucleic acid capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in a probe may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, for example, probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages. It will be understood by one of skill in the art that probes may bind target sequences lacking complete complementarity with the probe sequence depending upon the stringency of the hybridization conditions. The probes are preferably directly labeled as with isotopes, chromophores, lumiphores, chromogens, or indirectly labeled such as with biotin to which a streptavidin complex may later bind. By assaying for the presence or absence of the probe, one can detect the presence or absence of the select sequence or subsequence.
[0055] A "labeled nucleic acid probe or oligonucleotide" is one that is bound, either covalently, through a linker or a chemical bond, or noncovalently, through ionic, van der Waals, electrostatic, or hydrogen bonds to a label such that the presence of the probe may be detected by detecting the presence of the label bound to the probe.
[0056] "Biological sample" as used herein is a sample of biological tissue or fluid that contains genomic DNA. These samples can be tested by the methods described herein and include body fluids such as whole blood, serum, plasma, cerebrospinal fluid, urine, lymph fluids, and various external secretions of the respiratory, intestinal and genitourinary tracts, tears, saliva, milk, white blood cells, myelomas, and the like; and biological fluids such as cell extracts, cell culture supernatants; fixed tissue specimens; and fixed cell specimens. Biological samples may also include sections of tissues such as biopsy and autopsy samples or frozen sections taken for histologic purposes. A biological sample can also be skin cells, a cheek swab or a hair bulb sample. These samples are well known in the art. A biological sample is obtained from any mammal including, e.g., a cat. A biological sample may be suspended or dissolved in liquid materials such as buffers, extractants, solvents and the like.
[0057] The term "feline" refers to an animal that is a member of the family Felidae; including without limitation the subfamilies, Felinae, Pantherinae, and Acinonychinae; the genera Caracal, Catopuma, Felis, Herpailurus, Leopardus, Leptailurus, Lynx, Oncifelis, Oreailurus, Otocolobus, Prionailurus, Profelis, Puma, Neofelis, Panthera, Pardofelis, and Uncia; the species felis, lybica, jubatus, caracal, badia, bieti, chaus, margarita, nigripes, silvestris, gordonii, yaguarondi, pardalis, tigrinus, wiedi, serval, canadensis, lynx, pardinus, rufus, colocolo, geoffroyi, guigna, jacobita, manul, bengalensis, planiceps, rubiginosus, viverrinus, aurata, concolor, nebulosa, leo, onca, pardus, tigris, marmorata, and uncial.
[0058] The term "determining the contributions of feline populations" refers to estimating or inferring using statistical methods the contributions of feline populations to draw conclusions regarding whether one or more feline populations contributed to the genome of a test feline.
[0059] The term "feline population" refers to a group of felines related by descent, such as a domestic cat breed.
[0060] The term "breed" refers to an intraspecies group of animals with relatively uniform phenotypic traits that have been selected for under controlled conditions by man. For example, The International Cat Association (TICA) recognizes 57 Championship
Breeds, 2 Advanced New Breeds and 10 Preliminary New Breeds (identified at tica.org). The Cat Fanciers' Association (CFA) lists 40 breeds. The methods of the invention may be used to estimate the genetic contributions of any cat breed, including, but not limited to Abyssinian, American Bobtail, American Bobtail Shorthair (SH), American Curl, American Curl Longhair (LH), American Shorthair, American Wirehair, Balinese, Bengal, Birman, Bombay, British Shorthair, British Longhair, Burmese, Chartreux, Colorpoint Shorthair, Cornish Rex, Cymric, Devon Rex, Egyptian Mau, European Burmese, Exotic Shorthair, Havana Brown, Himalayan, Japanese Bobtail, Japanese Bobtail Longhair, Korat, LaPerm, Maine Coon, Manx, Munchkin, Munchkin Longhair, Nebelung, Norwegian Forest Cat, Ocicat, Oriental Longhair, Oriental Shorthair, Persian, Peterbald, Pixiebob, Pixiebob Longhair, RagaMuffm, Ragdoll, Russian Blue, Scottish Fold, Scottish Fold Longhair, Selkirk Rex, Selkirk Rex Longhair, Siamese, Siberian, Singapura, Snowshoe, Somali, Sphynx, Thai, Tonkinese, Toyger, Turkish Angora, Turkish Van, Chausie, Savannah, Bambino, Donskey, Highlander, Highlander Shorthair, Kurilian Bobtail, Kurilian Bobtail Longhair, Minskin, Ojos Azules, Ojos Azules Longhair, Serengeti and Sokoke, and mixtures thereof.
[0061] The term "marker" refers to any polymorphic genomic locus that is sufficiently informative across the feline populations used in the methods of the invention to be useful for estimating the genetic contribution of these feline populations to the genome of a test feline. A genomic locus is polymorphic if it has at least two alleles.
[0062] The term "allele" refers to a particular form of a genomic locus that may be distinguished from other forms of the genomic locus by its nucleic acid sequence. Thus, different alleles of a genomic locus represent alternative nucleic acid sequences at that locus. In any individual feline genome, there are two alleles for each marker. If both alleles are the same, the genome is homozygous for that marker. Conversely, if the two alleles differ, the genome is heterozygous for that marker.
[0063] Population-specific alleles are alleles that are present at some frequency in one feline population but have not been observed in the sampled feline from comparison feline populations (although they may be present at a significantly lower frequency).
Population-specific alleles may be used to assign an individual to a particular population. Accordingly, the difference in allele frequencies between populations can be used for determining genetic contributions.
[0064] A "set of markers" refers to a minimum number of markers that are sufficient for determining the genetic contribution of the feline populations used in the methods of the invention to the genome of a test feline. The minimum number of markers required depends on the informativeness of the markers for the particular feline populations that are being used, as further described below. The set of markers may comprise at least about 5, 10, 25, 50, 75, 100, 125, 150 markers, or more, as appropriate.
[0065] A "feline population profile" as used herein refers to the collection of genotype information for the set of markers in a feline population. Thus, a feline population profile may comprise genotype information for most or all alleles of most or all markers in the set of markers in the feline population.
[0066] An "allele frequency" refers to the rate of occurrence of an allele in a population. Allele frequencies are typically estimated by direct counting. Generally, allele frequencies in a feline population are estimated by obtaining the identity of one or both alleles for each of the set of markers in at least about five members of that feline population.
[0067] A "database of feline population profiles" refers to the collection of feline population profiles for all of the feline populations used in an exemplary method of the invention. In some embodiments, the database of feline population profiles comprises between about five and about 500 feline population profiles, such as about 20 feline population profiles, about 50 feline population profiles, or about 100 feline population profiles.
[0068] A "computer-readable medium" refers to any available medium that can be accessed by computer and includes both volatile and nonvolatile media, removable and nonremovable media.
[0069] The term "modulated data signal" means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal.
[0070] A "data structure" refers to a conceptual arrangement of data and is typically characterized by rows and columns, with data occupying or potentially occupying each cell formed by a row-column intersection.
BRIEF DESCRIPTION OF THE DRAWINGS
[0071] Figure 1 illustrates a map of random bred cat sampling locations. The pie charts represent the percentage of the eight worldwide lineages found at each location. The shading indicates the strength of the predominating lineage for each region of the world.
[0072] Figures 2A-F illustrate Delta K plots of random bred cat population structuring. Graphs of both the mean Ln(K) and ΔΚ calculations based on the results of Bayesian clustering. Top) SNPs only, Middle) STRs only, Bottom) SNPs and STRs combined. Points where a peaks in a ΔΚ plot occur indicate population stratification with higher likelihood than those where valleys occur.
[0073] Figures 3A-F illustrate Bayesian clustering of random bred worldwide cat populations. Clustering of cat populations using STRUCTURE A) SNPs K=5, B) SNPs K=8, C) STRs K=5, D) STRs K=7, E) SNPS and STRs K=5, F) SNPs and STRs K=8.
[0074] Figures 4A-C illustrate alternate Bayesian clustering of worldwide cat populations. Alternate clustering of cat populations using STRUCTURE based on ΔΚ calculations. A) SNPs at K=l 1 and 23, B) STRs at K=9 and 13, and C) SNPs and STRs combined at K=10, 16, 18, and 22.
[0075] Figures 5A-B illustrate principal coordinate analysis of world cat populations. A) SNPs and B) STRs by sampling location calculated via Nei's Unbiased Distance. Colors indicate the eight random bred populations. Circles indicate the five lineages.
[0076] Figures 6A-B illustrate neighbor-joining trees of world cat populations.
Bootstrap values over 50% indicated on nodes. Branch colors indicate the population as assigned by STRUCTURE. A) SNP-based phylogeny produced with Reynolds, Weir and Cockerham's genetic distance. B) STR-based tree produced with Nei's unbiased genetic distance.
[0077] Figures 7A-D illustrate log likelikhood and Delta K plots from the Bayesian clustering of cat breeds. Graphs of both the mean Ln(K) and ΔΚ calculations based on the results of Bayesian clustering. Points where a peaks in a ΔΚ plot occur indicate population stratification with higher likelihood than those where valleys occur.
[0078] Figure 8 illustrates Bayesian clustering of cat breeds. Clustering of breeds at
K=17 and K=21 as calculated with SNPs and STRs respectively.
[0079] Figures 9A-B. Figure 9A illustrates alternate plots of Bayesian clustering analysis for SNPs. Figure 9B illustrates alternate plots of Bayesian clustering analysis for STRs.
[0080] Figures 10A-B illustrate principal coordinate analysis of cat breeds and worldwide random bred cat populations. Color shades indicate the population membership of the respective random bred populations.
[0081] Figures 11 A-B. Figure 11 A illustrates crossed assignment rate between breeds as a function of the Reynolds distance between populations using SNPs. Figure 1 IB illustrates crossed assignment rate between breeds as a function of the Reynolds distance between populations using STRs.
DETAILED DESCRIPTION
1. Introduction
[0082] The present invention is based, in part, on the discovery of a panel of biomarkers useful for the assignment of domestic cats to specific breeds or world populations based on the frequency of genetic markers in their genome. Assignment testing utilizes microsatellite and/or single nucleotide polymorphism (SNP) biomarkers, as well as genetic biomarkers that are known to confer a physical characteristic or disease state in the cat. The combined panel of over 200 different genetic tests can be used to determine if a cat is from a specific breed or random bred population of origin within a database of approximately 2000 cats. To conduct the test, the genotypes of the panel of biomarkers are determined in a biological sample of the cat (e.g., blood, tissue, hair bulb, buccal swab) comprising genomic DNA. The genotypic "signature" over the panel of biomarkers of the test cat is compared against a database of the same panel of biomarkers with identified frequency associations with known cat breeds and random bred populations of origin. The frequency of the DNA variants of the test cat are compared to the database to match the test cat to the population with the most similar frequencies, allowing assignment to one or more breeds and/or ancestral lineages of origin. Using the biomarker panels described herein, it is possible to determine the geographical region of the genetic origins of the test cat, whether the test cat is highly related to a known breed, or whether the test cat has a parent or grandparent that is of a known breed. The present genetic assignment tests also find use breeding strategies, e.g. , to facilitate the selection of a mating partner that is genetically dissimilar, or as a new foundation for a breed stock.
2. Felines Subject to Testing
[0083] The methods find use in determining the contributing feline populations of origin of any feline, e.g., any member of the family Felidae. Oftentimes, the feline will be a domesticated feline. In various embodiments, the feline is a member of the genus Felis. For example, the feline may be a member of Felis silvestris or Felis catus. The feline further can have one or more identifiable phenotypic or morphological features associated with one or more recognized cat breeds, by a cat registry. For example, the feline may have genetic contributions from a cat breed recognized by one or more cat registries selected from the group consisting of The International Cat Association (TICA; tica.org); the Cat Fanciers' Association (CFA; cfa.org); The Australian Cat Federation (ACF; acf.asn.au); Co-Ordinating Cat Council of Australia (CCC of A; cccofa.asn.au); Federation
Internationale Feline (FIFe; fifeweb.org); Governing Council of the Cat Fancy (GCCF; gccfcats.org); The New Zealand Cat Fancy (NZCF; nzcatfancy.gen.nz); The Southern African Cat Council (SACC; tsacc.org. za); The World Cat Federation (WCF;wcf- online.de); American Cat Fanciers Association (ACF A; acfacat.com); The Traditional Cat Association, Inc. (TCA; traditionalcats.com); International Progressive Cat Breeders' Alliance (IPCBA; ipcba.8k.com); Canadian Cat Association (CCA; cca-afc.com); Cat Fanciers' Federation (CFF; cffinc.org); American Association of Cat Enthusiasts (AACE; aaceinc.org); Australian National Cats (WNCA; ancats.com.au); Capital Cats Incorporated (CCI; cci.asn.au); Catz Incorporated (catzinc.org); Council of Federated Cat Clubs of Qld (CFCCQ; cfccq.org/index.html); The Feline Association of NSW (TFA of NSW;
tfansw.webs.com); Feline Control Council (FCC; hotkey.net.au/%7Efccvic); Gold Coast Cat Club Inc. (goldcoastcatclub.com); The Governing Council of the Cat Fancy of South Australia (GCCFSA; users.chariot.net.au/~gccfsa/index.html); NSW Cat Fanciers'
Association (NSW CFA; nswcfa.asn.au); Queensland Feline Association (QFA;
qfeline.com); Queensland Independent Cat Council (QICC; qicc.org.au); Hong Kong Cat Lovers' Society (hkcls.com); Korea Cat Club (KOCC; kocc.or.kr/link/link.htm or ticakorea.org); The Cat Federation of Southern Africa (CFSA; .cfsa.co.za); The Asian Cat Association (ACA; asiancats.co.uk); Bavarian Cat Fanciers' Association (bavarian- cfa.de/bcfa.htm); and Feline Federation Europe (FFE; ffe-europe.de).
[0084] Illustrative breeds include without limitation Abyssinian, American Bobtail,
American Bobtail Shorthair (SH), American Curl, American Curl Longhair (LH), American Shorthair, American Wirehair, Balinese, Bengal, Birman, Bombay, British Shorthair, British Longhair, Burmese, Chartreux, Colorpoint Shorthair, Cornish Rex, Cymric, Devon Rex, Egyptian Mau, European Burmese, Exotic Shorthair, Havana Brown, Himalayan, Japanese Bobtail, Japanese Bobtail Longhair, Korat, LaPerm, Maine Coon, Manx,
Munchkin, Munchkin Longhair, Nebelung, Norwegian Forest Cat, Ocicat, Oriental
Longhair, Oriental Shorthair, Persian, Peterbald, Pixiebob, Pixiebob Longhair, RagaMuffin, Ragdoll, Russian Blue, Scottish Fold, Scottish Fold Longhair, Selkirk Rex, Selkirk Rex Longhair, Siamese, Siberian, Singapura, Snowshoe, Somali, Sphynx, Thai, Tonkinese,
Toyger, Turkish Angora, Turkish Van, Chausie, Savannah, Bambino, Donskey, Highlander, Highlander Shorthair, Kurilian Bobtail, Kurilian Bobtail Longhair, Minskin, Ojos Azules, Ojos Azules Longhair, Serengeti and Sokoke, and mixtures thereof.
[0085] The feline breed assignment tests were developed based on the
understanding that 44 breeds are genetically definable of the world's 54 major breeds, not including longhaired and shorthaired varieties with the same breed name. The assignment test described herein attempted to include all breeds recognized in three or more of the following registries: CFA (USA), TICA (USA), GCCF (UK), and FIFe (Europe). However, the assignment of a cat to a breed was mainly based on USA populations. Cats representing breeds from other world regions will therefore be assigned to a cat breed in reference to the genetic structuring of USA cats.
[0086] Additional populations can also be added. For example, breeds that are considered preliminary or under development, as well as breeds specific to a particular geographic location (e.g., breeds or populations specific to an island location), can be added to the databases described herein, first as a preliminary breed and then as an established breed. For example, the Selkirk Rex and American Curl breeds are under development. Also, additional analyses could be used to further refine population and breed definitions when compared on a less global and more regional scale.
[0087] It is recognized that the definitions of cat breeds vary between registries around the world, and that different breed registries accept and refuse different color varieties and variants, sometimes even defining a breed. For example, some registries define a Himalayan as a pointed Persian. For the sake of reference, the CFA definitions of breeds were used in the tests described herein to make assignments. Thus, a pointed Manx, which may be a defined breed in another cat registry, may seem to have an inappropriate assignment. Straight-eared Scottish Folds and tailed Manx may be difficult to define if not only by their breed heritage. These nuances of breed definitions need to be considered in the analysis and interpretation of results. It is further recognized that many breeds may have longhaired and shorthaired varieties, some using a different name, such as Manx and Cymric.
[0088] In various embodiments, the feline is a hybrid, e.g. , having genomic contributions from one or more wild felids. For example, the Bengal is a cross of various cat breeds and random bred cats with various sub-species of the Asian Leopard cat (Felis bengalensis, a.k.a. Prionailurus bengalensis). The Chaussie breed is a cross of various cat breeds and random bred cats with various sub-species of the Jungle cat (Felis chaus). The Savannah breed is a cross of various cat breeds and random bred cats with various subspecies of the Serval (Felis Serval). Some cat breeds are mixtures of these various hybrid breeds, e.g., the Desert Lynx.
3. Biological Sample
[0089] The methods may comprise the step of obtaining a biological sample comprising genomic DNA from the feline to be tested. The biological sample may be obtained in the laboratory conducting the analysis or by another party (e.g., a veterinarian, a guardian of the feline). The biological sample can be from solid tissue or a biological fluid that contains a nucleic acid comprising a single nucleotide polymorphism (SNP) described herein, e.g., a genomic DNA sample comprising a plurality of the genetic markers listed in Table 1 , particularly the SNPs depicted in SEQ ID NOs: 1-148. The biological sample can be tested by the methods described herein and include body fluids including whole blood, serum, plasma, cerebrospinal fluid, urine, lymph fluids, semen, and various external secretions of the respiratory, intestinal and genitourinary tracts, tears, saliva, milk, white blood cells, myelomas, and the like; and biological fluids such as cell extracts, cell culture supematants; fixed tissue specimens; and fixed cell specimens. Biological samples can also be from solid tissue, including hair bulb, skin, cheek swab, biopsy or autopsy samples or frozen sections taken for histologic purposes. These samples are well known in the art. A biological sample is obtained from any feline to be tested for the genotype of the genetic markers as described herein. A biological sample can be suspended or dissolved in liquid materials such as buffers, extractants, solvents and the like.
4. Biomarkers Useful to Determine Breed and/or Population of Origin
[0090] Genetic markers useful for the determination of the contribution of one of more feline populations or breeds of origin are listed in Table 1. The methods of the invention analyze in a test feline the genotype of a plurality of genetic markers depicted as SEQ ID NOs: l-148 in Table 1 , also identified by their chromosomal location.
Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
1 A1J0141047 TCAATAG CAG G AG AMCAAGATCAMCCATG CCCGG GTTTCAATG CCTTG
GGGAAATAAC[A/G]GAGAGAAGGAAACTTTATTAAGGCGATCCCGTCAACT CTACCCATTCCTCGGAGGCGTTT
2 A1J33621071 GTAAAACACGACAACATAGAATGACACTCACTGTGGCAGTCGAAAAGAGG
TACTTGGCAA[A/G]TACCATGGGAATGTCATACGGGATGCATGCTACTGGA GGGATGTCTATAGCCTTTCCACT
3 A1J51648701 TAGCACCAGATCAAAAAATGAGTGGATTTCCCTGTCTAGCTCCTTCACCA
CCACAAGTTC[T/C]GCATGTTTGGTCTCATCAGGCCCCACGATGACATCCA GGGCAAAGTGCTCGCTGGGGGAC
4 A1_175780586 TTGTGGAATGACACCGTCAGAAAGGAGATTTCTTGGGCTACTGTGGTAGC
TAGATTCCCG[T/C]GGAAGGGCGTGCCTTTCGGTTACAACGTATTGGTGC TAGGCTGCCTGGACCACTGGCTTT
5 A1_208054462 GAAACGGAGTCACAGGAAGTAAGGGTTGGTATTATATTTTTAGAAGTATTT
ATTGGGGGA[C/G]GGGGGATAAATAGGTGGGCTCAGAGAATAATATTTCC AAG GTCACAG GG CTAATG AG CCT Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
6 A1_223501140 AGTGATCCAAGGAGGTGACGAGGGACCATAAGCCTTGATTTATGACCTGA
GGTTTCCATC[T/C]CAGAAGCCACATCATCAGTCCCTCTGGGAAAGAGTTT TAACTGGATGAACTGCCCTTCTA
7 A1_223506906 GTTCATTGAGTAAGATGTTCATCACCCTCTTCTTAGAAATAAATTCCCTTT
GCTTCATCA[A/G]GGAATCATGAACCCTTAGAGCTAGAAACGACTTTGGAG GTTATGTGTTTAAGTGTTTTTG
8 A1_225057933 AATTACCCAATTCCTCCCTAGTTATCGTATTCAGTGACACAGATAACAAAA
GTTAGAAGT[T/G]CTTCGATTCACATTCACAAAGATGCACCATGAAATCATA GTAACTTGGAGTAAGTGGCAG
9 A1_235579538 CTTTTGATTCTATTTTGGGTCACACGTGAAACCCACAGAACAATCGACAAA
AGCCATTTC[A/G]TCTTCTCACTCTCTTCAGTTTACCCTTTTGCTTAGTTTAT TTCATTTCGCCAACATTTTT
10 A1_27523501 ATGCAGTCCTGCCTAAATGTAGGAGAGTCCTGAAGATTTTCTGGATCTAA
TCTCTACCAT[T/G]TTGTGCCAAGTTTGAGGACTCATTATACTTTAGGCTTT ATAAAATATTTCTCCTCTGGGT
11 A1_68485376 ATTATTTGCAGGATCTACGTTCATTACTTGAGACAGGACGATTCATTAAAT
GTTAGAAAT[T/C]AATTCGTGGAGCAAGTAAAAAGGTGGAAGAAGTGTTAG GAAAATCACTTGAGAAAACGTA
12 A1_69424718 AACTCAATCAATCCAGGCATCCTTGTCTGACCAGGAGGAAAAAATAAACA
CAGCAACGTG[A/G]AGGCGGAAGCTCGTGCTCTGGAAACAGTCAGACCTG ACTCAATTCCAAGCTCCCGGATGT
13 A1_7429296 GAGTCAAGCTGTCGCTGTTTCTGGTGCAAAACCAGGCACAAGGTACACA
GTGATATTAAA[A/G]GCTCGTGGGCAAAACACCTTCCTCAGCCCGGGAGC GACACCTGTGGCAATATAATTTGAT
14 A1_8742286 CCTTCCCTTACTGAGAGACAGTCAATAAACCTTCAGAGGAGGGCTAAGCA
TGACCCGCAG[T/G]GATCCAAGAACACACCAGAAGAAAGGGGATCATCAC AGCCAATGCCAACGTAGGGAGTTG
15 A2_152258936 CTAAAACTTCATTTGGTTAAAACAGAAGAAGAGTCAAGCACTTCTCTTCCT
TGTGAGCTA[T/C]CATGTAGCCAACACTCTGAACATAACATGCGCAACGGG AATATACTCAGCTTCCCAACTC
16 A2_201526186 TCGAGAAATAGGGGACACAGCAATTCAATCTCCTGGTTAAACCAAAGCTT
AGATGAAGAC[A/G]TCTGGTTCTTTAAGCCTTTCTGCTGAAAATAATCATCC GAGGTACTAAGGTCCCTTTTGA
17 A2_202225770 GCAGAATTTGTCGTAAAGAGAATTCTCACACGTGAGGACTTTCCCTCTCTT
GTGTTGCAT[T/C]GTCAAACTAGACCTGCATTTAGGCCCCTGGTTGTATAA ACTCCAGCTTAGTTATCCAACG
18 A2_44241149 GTTTTTCCTGAACCTTCCCACCTTTAATGCATCCTGGAGCAGTCCTTCAGC
CTGCTTCCC[T/G]CCAGTCTTCTTACTCTTTCATTTTAAATAATGTAATAAC GTTGACATTTTCATTTAGAGT
19 A2_554046 GAACCCACTTTGCAGATGGGAGAACCATGGGGTTACACTTCGGCATCTC
CCTGAAATCTG[A/G]TGAGACACGGAATGGAGGCCTTCTCAGCAGATACT GGGTGAGAGTCACATTGATGTGCTG
20 A3_101420069 CAG ATTTCAGG G AG CAAAGG G ATCAAATTAACTTTTCTCATG GTTCTATTT
TTGTGACTC[A/C]ATTCTTTTGGAGGAGAGAGTCAGGATGACTGGTGGGAT TTCCAGAAAAGCCAGAAACAGT
21 A3J2082294 CAGACACATTGGGATCATGAAAATCAGCCTCAGTTTCAAAAATAAATCTGT
TACCTCCAT[T/C]AATCATGAAAAACAATTGGTCAATGGCCTGCAGGGGTG GCAGCTGTGTCAAAGCAGGGGC
22 A3J30195244 ATATGCTCAATAAATAACGATCACTCGTTTGCTTATTACTCGTTCGGGTGG
GGATACAGA[T/C]GTATATACCTAAAATTACAAAACAGCGTAAGATCTGTC CTGGTTACATGTACCAGGTGAA Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
23 A3 159537633 CCGCAAGTTGGGCGGAGGTTAGGTGGGCAGACTCACCTTCTTGTCCATG
AGGCAACCAAA[C/G]AGTAAGATGAAGACACCCTTAACGGGGGGATACGG GGATAAGTTAGTCACGGAGGAAGGA
24 A3 162208567 ACGAGTCGTGTTAAATAAATCGAGGATGGCATTGTTAGTCCTCTTTCCTAA
GTAACCTTC[C/G]AGGCTGTCAGATAAGCTCTCCCTGTGGTTTCTGTTCTC TTTTAGAATGAGCCCTTCCTGA
25 A3_38781591 AGCATTTATCAAAGGAATGATAAGGAGTAAAGTAGAACATTAGTCCATAG
GTGAAAGCCC[A/G]TGAGAAAAAAATTAAATGCCCAAGTCATTAAGTGCAT
GGCTTGACAAATTGTTTAAAAGg
26 A3 75156179 CTATACTAGTTTTATATCATCCTTGCCTGTTATGGATCGAACGAGTGTTTTT
CCTGCTGT[A/G]CAAAAACGTTCCTTGACAATATATTTTCTACCAATAATCA
TTATTTTAATAAAACCAGTG
27 A3 91058022 GTTAAGCCCATCTAACTCCTGAATTTTTTCGTGTGATTGTTTCATAGAAAA
GGTAAGCTT[T/G]CTGGGAAAGCAGGTATGGAGAATTTTTATTTTAAATCCT
TGAAACTGTGACAGATGTTTA
28 A3_99507784 CAGCACAAACATCTCCTATTCCTTCCTTTCTCATTCCATAATCCTTTGAATA
TGCATCCA[A/T]TAAAACACTTAACACATTGTTCTGTGTCAGGAGTGTCTGT CTCTGATTAGACCAGCAGTT
29 B1 10420438 GGGTAGGGTTGGGAATGAGGGTGAAGGTAGAAGGAGGGATAGAAGGAC
AAGAAGAAGCAA[A/G]GAGCATCCTGGACAATCTGTGTCATTAGCTTCTGT TTG CACATG G CCAAG G CACTTGCTT
30 B1 12214271 CCTTCCTCTTCACCCTGCCTCTCGGGCATGAGTCACCATTTCCTCTTAAAA
TATGGAGAA[A/C]TACCAAACGTGGCTTTCATGTGGGTTGCACACGTGGTA ATGACTGAGTTGGGAAGACCAC
31 B1J95678303 TGGAGGGCATCAGAGATGTTAGACACCATGGGCAGGCTTACCTTGAATTT
TAG GTG CTCC[A/G] AG G CTCTGAG GTTCTCCATCATAAAGTCAAG GATTTG ACAAGACTTGAAGTTGTTATTGA
32 B1_199564532 TACTTGGAAATGTTCATTTCTGAGCTTCCTGTCTGTCGTGGAATTGCTGGA
GAATGGAAA[A/G]TGGGTTTCGTTTTCTCTGAGTAGTGAGGACTTTAAGCC TCTGCACACATTTGTTGCCTTT
33 B1 202966562 AGTCATCTATAACTCAGAAAAAATAAGCAACAGTATAATCCTTAACCTTGT
TAACAGGGC[A/G]GGGGTGTAGGGGGCAAGCACAAACTAAAATGACACAG
GGTATTTCACTAGTTTTTTTTTT
34 B1_54775572 TTTTAATGTATGCTCTTTTATAAAATCTGCATGGCCATTCCGTGTATATGC
GTTTTTAGC[A/G]TGTGCATAAATGATATGTTCTGCGTCTCATTTGGTTTCT TATG GTTCAGTCAG CACTGTT
35 B1_80161671 tatGTAAACACTTATTGAGTATCTATTGCCCTAAAGGGATTCAACAACAGCT
CGATCATA[A/G]TTATAAGGCACAAAAGAGAGATGAGTTTAAGTCTCTACTT
TGATTTTAAAAACTTATATT
36 B1 88148379 CAAGGACCCAACTTGGGTCCCATCCCCATGCCCCACCTCACCCCACAGC
AAGACGTCTTT[T/C]CCATATTCACTGCTCTTCCCTTGACTTCTGAGAGCTT TTG CAATCTACATTTTG ACATTT
37 B2_138312489 TAGGAGGTTGATGAAAGGCATCCGGATCAGGGCCAAGGGTTTGATCAAA
AGCCCAGTAAT[A/G]AGAGTGAGCAAAGTGTAATGTTAAAGAATCAGAGTG CATCCTACTCAGATGTGGCAAAGG
38 B2_146660650 ACAGATAAGTGTCCGTGTTCAGTGGGCTCAAGCCTCCTGGCTCAAGAGA
CTATGGTTTGA[T/C]CAGTCTTCTAGGTGAATCAAAGATAGCTGACTCTGA GGCTTTGACCCTGGATTTCAAGAG
39 B2 41509834 ACAGAGGGCAGTCACCATGGTCACTAGTGGGGACAACGAGGGAAGACTC
TCAGGAGACAC[A/G]AAGGTCAGAGTTTACTCTAGTGCCAATAGTAATAAC ATTTACGAGGTCCCCACTGTGTGC Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
40 B2 45093345 AGCTCTACAGTTCTGGAAGCTTCCTTAGGCTCCTCCTCTACAGTCCTAGG
CTCAGGCACA[T/C]TCTTCTGGGTGAGGAAGCATCTGTTCCAGAGGATGA GTGTTTCAAGGTTGACTTCCTGAA
41 B2 6949528 CAAATGGGCATAGGTGTTCAAAATTAAAATTAAGTCGTCTGGCATCCAGAT
GAGAGAAAT[A/G]GAAGTTAGAAGTCAGGGAGACGTTGTGCACTGGGCCC GTGATTTGCTGCAGGGCCTCCAT
42 B3_104483970 GGGTTACACTGTTTATGCGGTTGTACAGATCTACAGTTCTTAACAGTTGG
GTTCTGCAGT[A/G]TATTACTCTGGTGTTAAATGGAGGATCATCTGTTTTAG
ATCACAGATTTATTATTCTATT
43 B3 111000326 AAGCAACCAAAAGGTGAACTGTTGATGAGCAGTGTCCTGCTTGATGATAT
TTATCATGTG[T/C]AGCCCCTCCTGAACGTTGACTCCGCGTCATGGCACAC AATTTTCTGATGACAATATACTT
44 B3 13666494 AACAAAG CAG CCCAG CTTCTCAGG GAAGTCTTCTACCTG G GTG ATTACTT
AACCTTTCTA[C/G]AGTTCTGCGGTATTTTTCTCTAGGGCAAAGTCGTAAAA
CCGCCAGGTTTGGGTACAGCCC
45 B3J9203469 CCAGACAGCTGCCAGATCCGGGGGGTGGGGATGAGGGTAAAGGGGATG
GGAGTTATCTCC[T/C]TGCCTTTATGGCTGGCACCTGGAGCCAGGCTGGG TGATTCAAAAGCACTTGGCCAGAGAC
46 B3 51317931 GGCAGTGTGGGAATAAATATTTATAGGCTGGGCTCTGAAACCAACATATT
CTCATTTTTT[A/G]TAGAGCCTTGGGCCAGGCCTATGCCAAGTGAAAATTA ATTTACCCAAGAATTTCTTTTCA
47 B3 57141954 TCCTGCCATCACAGTGGGCACCTGTCAGGTCACAACTACTGACCAAAGA
GAAACCCAGCT[C/G]CTCACTTCTGCCCCTCCCACAGATAAGCAGAACCC CCAGGACCACCATCACTGTGAATGA
48 B3_77094074 GCCTGATGTTTTCTGGTTGGTGGGTGTATTTATCCTTGTTCCTTCTGTCCT
GACCAAGTC[A/C]CTTGCTTCTACAGAGTGAATGGAGCCTAGACTAGCTAA AAATCAAGATTCTACCACTTAC
49 B4_105706694 ATTAGAAACATACCAATAAATGTTATTATTTGAAAAAAGATTTTAGACTCAC
TGAAGCCC[A/G]CAAATATTTAGGCTTTGCCCAAATTTATTTCTACACTACA GGAATTTGCTCAACTACTTT
50 B4 142658074 AG G CCAGAACAATAATATG CCCTTCCG GAAAG GTCTATCACATTCTCAG G
AGGCAAAGGT[A/G]GCTTGAAAAAGCATACTGTAATGTACACATCTAGGAA GGTGGAAGGAGCCTTCACCTGAT
51 B4 143006494 TTTAATTATTAGTTGTACATGATGCATAACCACTGAACTTTCTCTGCATTAA
CAGGATGA[A/G]TATCAGGTAATTAGTGCTCTGACAGTGCTCTGATAATTA GTG CTCTGAGTCCTAG CATTT
52 B4_144693308 CTTCTCTTGGCCTGGAGAGAGCATTGAAGCCACTCCCTCTGTGGGTGCC
TCGCTCCATAC[A/G]TAAACACATGTCTACCATATATACACAGGCACACAC ATTTGTCATTCCTTCCCAGAATGA
53 B4_146486983 AGTTTGTGCTCACTTGTGTTTTTTCCTAATTGTTTTATGTGGAAATGTTTTA
TCTTCATG [A/G] CAG CAG AACACATTCCTTG AG G AAAAAACAATATGTCTT CACTTTATTTTGTCCCCTAAT
54 B4 149532846 TGAGGCCTGGCCAGATCTCCCTGGCCATCTGGGTCCCCTGGCACAGCTT
CCTTTGGTGAC[T/C]CGAGTAATCGTAACAGTTGCCATATAATTGAGGAGC GGCCATGGTGTGCCATACGTCAGC
55 B4_20001848 GGTGTAAGGAGAGAAAACGGAAAAGCTATTTTAACATGAGTTCTCTCAGA
ATGGCGTCAT[T/C]GTGAGACCCTTGTACTTTATTCTCTTTTTGCTTATCTG CATTGTTAAGTGATCTGTAGTA
56 B4_21098349 TTTGTTTGTTACAGGAGATTAAGGGCCTGGCTTCTCTTTGACTCTTTCAAG
TTTACCCAA[A/G]TTCAGAAGTAGGATCACAACACAGCATTTTGTGTGGAG AACCATGTCTCAAATATACAAC Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
57 B4 255106 TCGCCCATATGGAGTGCAGCAGCCCCTCTGTTAAGGCAATTATCTCATTA
TCGTG G GACT[T/C]TTG AG G CTGTCTTTTATG CTCACCATGACTTTCTTAAT GGGTTTCATCATGTTCGCCTTT
58 B4 3093827 GCCCCGTCATCCAAACTGTTCAACAGGGGAAGGGTGTGAGGCTGACCTA
TGTTGTCCACA[T/C]GACCCCAGAAGGTCTAAGAGAAGCAGGTGTCGTTG GTGCTCAGCAAGTGCCCAGAGCCCC
59 B4_40319102 TTCATAATGAAGCCTGGAATGCCTTCCTCCCAGTTCCATTTGTCCTGCTCC
TCACCCCAT[T/C]ACTCTTTATTTCCTCTCCTGCTTAAGTTTTCTTCAGAGC
TCCCACCCTGTGGGACATGCC
60 B4 47638578 ACCCCTGCCTCCTTTCCCTCATACCTAATAGGAGTCCTCTGTATGTTCACC
AGTGCAGCT[A/G]AATCAAGCTGCTGAGAGTTAACCAAATAAAAGAAATAG GTCTAGCTCTCCTGTAACTGGC
61 C1 116355295 ATCTATCTGGCAGCCCTTCCACCAGCAGTGTATTTCCAAATATCCCACGG
GGCTGTCCTC[T/C]GTCTCTACTGTGCCATCCTTTCTGTCTGGACCATCTA AACAGAGTTTTGGAAGCACCACA
62 C1_123164748 GTTAAGTGTAAGCTGCTGTATGGGGATTATCATTATTTCTTTTGTCAGTGA
ACCATCACT[A/G]CTCTTTGCTCCCTTGCCTCCCCACCTCTGTCTGCCCAC CCCCTTCTTGCCAACCTTTCTT
63 C1 190502133 GCCCCTCTCATCTTGGGCAACACTTCACTGGGTGAGTGATTACAGCATTT
TTCCTCTCAC[T/C]GCCAAGCTGGTCCTCCTGTCCCCTACTTTGCTCTCAG TCTATAAAAACTACTTTTTAAGG
64 C1 215441574 TGTTGACTAATGTGAATAATGATTCTTTTTTTCTATTAAGAAAAGAGAGGAA
CGCATCCA[A/C]GTATTGAGTACACTACCAGCCAGGAATGGTGTATTTTAC AG GTG G GCATCTAATCTAAG A
65 C1_24148281 TGACTATCTTGCCCCCTTCCTTTTGTAGCAACCCTGTTCTCCAGGGTCTA
GTAAGACAAG[A/G]CATGGGAAAACACTTTGCCGTTGCAAAAGCATTGTAT
AAAGTGATGCACAGAAAATGGGA
66 C1_28702055 TGTG AG G ATATG G AGACATCACATAAACTAACAG ACAACTAG ACTTAATCA
ATG GTG G CT[A/C]ATTAG G AG AAG ACTCAACAGTG G AAG CTTCTTAGTTG G GCACCGAAGGTTTCCTGGGAGC
67 C1 34981315 TGTTCAGATATTTGGGTGTTCTGGTTCAAAACTGGTTTCTCTCAAGATTCT
GATAGACCT[T/C]GCCAGCTGCAGATCCCAGCCACCTTCAAACCCATCCTT
AGGTGGCCTCCTCTCGAGACTC
C1J96397 AGACAGCGCCATGCCCGCATCCCGCCACCCTCCCCTCACGCGTCTTCCC
TGGTAATTATG[A/G]TTTTCAAAACTCACCTGATATAAAATTTACCACTTAAC CTTTTTTATTACTTACTTATTA
69 C1_44520932 TCAGGTACGAAGGCTCAGGTATGGAAGGCGGGTATTTTTTAGCCTTGAGA
AAG GTTTAAG[A/G]TCAAG AAGG ACAATG G GTTAAG CCATCTGAG CAAAG GATCATCTGGTCAGAGACAGGAAA
70 C1 52456776 GGGGAGAGCACATGGCGGGGAGTGGGGGGGCAGGTATACGAGATGTTG
CTCCAGTGGAAC[A/G]GATAGAAAATGAGAGGAAGAGGTTAGACAGGAAG GGGTTCGGGTTGATGCTTAGTTCTAG
71 C2_106991233 AAAAGTTGTAGAAAGAAAAAGAAGCATACAAAAGTGCTCAGTGAAAAATG
AGAGGATATC[A/G]CCCAAAGGCAAAGGAGCTACAAGCATGTATTGACAT CATAGTACGGAGTACAGACTCAAA
72 C2_147124460 GTTCTCTTCACACACG CCAG GATATAAACACAAACTTTGCAAAG G CACTT
GTG CCTCACC[T/C] GCTCATTTTCATG CATAAATCAACG G CTATTTCTTACA CAAATG G AAACAAATTTAAATT
73 C2 150774106 TTCAGCAATGGTATAATATCTCTGCAGTCTGGATTACCCAACAGGCAGTT
CAAATACACA[A/G]TTAGGTGTCCCAAACTTTTATTGCTATACTTTTTCATTT
TTAATATACCTATGGAGAGTT Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
74 C2J56491175 TTGCTACTGCTACCAGGCACAGAGACTATTCTGCCAGGGCAGTTAATTTT
CAATCAGGAT[A/G]CACATTTCAGGGTCTGGGGTGCAGGCATATGCAGTT AGGGCAAGTTCCCCAAGAGATTTT
75 C2_262401 TTGTTCCAAGCGGGAGGGTAGACCTGAGTTCTCTTGTCTGAATTATCCTA
TTTCCTCATT[T/C]TTTACCGTGGAGCCGTCTCCTCTGGCCCAGAAGCTTC CTGGAGCCGAGTCTATGGGTTGT
76 C2_5215469 TAAATAAAG GAGCAAATG AATATAATGG G CTTATTCAACTCTCAAG AATAA
AGATGGGTC[A/G]CTGCTTTTAGGAAATGGGATGTGTAAACACCCACCCA CACCGTCCTTCCCTTTCACCATG
77 D1_101321498 AGGAAGAAGGTTATGTTATCCAGTGTACCTGGTGTTCTAAGGGGAGGCTC
TTGGAATTCA[A/G]ATACAGGCCTGTCTAATGCTGAAGGTCTTGACTTCTT GGCCAGGCCATCTTGTTTTCAGT
78 D1J04941557 GATATTCTGTACAGCTGTTGTGCAGCTTGTTGCCACAGCAATGGCTAAAT
TTCAAAG GTG [A/G] GCCCAG GATATGTG AAGTAG GG CATAG AAGATTTCC AACACACCCAGGAACCTTTCCGGG
79 D1J05498119 GCAGATGTCTTGTCAAAACAGAATAAGAAACTGTGAAGAAATAGTCTGTG
AAACCCAGCC[A/G]TGTCCTGCTTCCTCTCATTTCTGGGGTAAAATAGCAG CGGGGGGAAAAATGGCTTTTAGT
80 D1_10789012 GTGAAGAAAGAGGAGTGATGGGGAAATCTGGGCTCACTAGGTGTAGCCA
CTCTCTCCTTT[A/G]GAATGTACTGGCTAAGCACTGACATGTTCTTACTATT CAGTTGCCTTCCTTATACAATTT
81 D1_11484008 TGGGTCCAACCTTTTAACCCATTTCTTCACCCATTTGTCTACAGTGGAGAC
ACCAGAAGT[T/C]GTCTAGCATCTTAAGAACAATTGCTCTCACTCTGAATG GTGGGATAGTCTGGTTGCCTGG
82 D1_117527468 CACCGAAATCTCTTCCATCGATGTCCAGGTGGTGCCAATTGCAAAATATT
GCTTCCCTTC[A/G]ATAGTATAAGGAAGTACACGGTCTTTTGCTCCGTACT CGTGAATAACGAATGGGAAGCTT
83 D1_125811329 CTGGCCTTTGGCTCAGGAATCTGTCGGCGAAACCAGTTCTGATTTCTTTT
GCCCCAAATC[A/G]TTTGCTCAAAGGTAATGAATGCGGTGGCAATTCTCAG TTTGTGTCCTGCTGTAAATATCT
84 D1J26256993 CAGTGAAAGGGCACCTTACCAGCAAATAGGCTTAAGCGACGACCTTACAT
AAAGACAGGC[A/G]TTTGGAACCTTCTGCCCAGAGCAGCTCCACCCTGGA GATCCTGCCCAACTTCCTGATCGC
85 D1J26847301 ATGGGCATGGCTTCCCAAGACATATTTATGAATTGAGGATCTGATAGAGA
AGGTAAGATG[A/G]GGTCAAAGTGGGGAAGTAGTCAGCTCTAAAACAAAA ATGAGAAATCCCGGGGATTTTAAG
86 D1J5984279 GTGGCGTGAACCAAGATAGTAGAAAAAATGGTACCAGTTTCGGGGAGTC
ATCAAAGGGTG[A/G]TGTGTTATCTATCACTCATCTTCGGTACGGAATTCC TGCCTACCCTGAAGATAAGCCTGG
87 D1J8390852 TTCTTGTGAAAGCCTACCCTTCCCACACAGCTGCAGCTGCTTTGAATGAA
TG G GAGTTCA[T/C] CTG GG G GG AAATG GTCTATTG CTCTGG G GAATTG CT GTCCTCCCCAGAGGCTGGAGGGCA
88 D1J8570323 CCCCCCCCCAAGCTTGGGTGGGTTCTCTTACTAACAATTTGTAAGCACCT
GG GAG ATG CA[A/G]AG GTG CTTTTTATTAATTTCTTAACTTAAG GAAACATA GCTGAAAGGAAATTCTGGATTA
89 D1_66177762 AGACCAGAATGGGCACAAAAGGGGTGTTAAGAGAGTGCCACCTAATGGA
AAATAGGAACG[T/C]CTCCCTGGGTTGCAGAGACAGGTTCCAGAGCCCCA GAGACCCAGAGCACCAGCCTTAAAA
90 D2_1020904 TGAGCTAAATTTGCTTTTTGTGAGAAATTGATGTCAGTGTTTTCACTGCAT
TTATGAACA[T/C]GTTATCATCTTTGGGAGAGAGACCAGAAGAGTAAAATT GAAGAAGAGTACAAAGGGATTG Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
91 D2J05772916 ATGGGAAGAACGGGGACCGCTCCCGAAAGTTCCGAGACTTTCTATCCTG
GAAGAATGAAG[T/C]AATTCCCACTCTTGTCTCCAGCCGGGGAAGGGGGG GGTGGAGAGTCATGTGAGCCGCCCC
92 D2_1752007 AATGGAGGAATTTTGCCTTGTGAGCCTTCACTTACCAACAATGATGTGGG
TACCTAACTT[T/C]TGGCGCATTGATCTCTTGACTTTGCTGTACAATTTTAA CCTCTG CAG CTTTAATTATCTT
93 D2_56777338 TACCAGGTTGGAATCTTCCTTTCTGTGTTTTCTCTAGGGTTTCTAGGACAC
ATCTGCTTC[A/G]TTTGCCCTAAATCTGAGTCCCACGGGGATGTGTAAACA GTTATTACATTTCCCGCAGGAC
94 D2_74293444 GGGGCCCAGACTGTGAGTGTGTGCAGAACCAGAAGAAATAGGAGTGGCC
CATGTAGGCTG[T/C]TCCTTCTAGAAGTGCAAAGAAGAAGCTGGAGGACA GCTCAAGAAGGGTGTGGGGTCAGGG
95 D2_91989307 AG GAAGG ATGACACTG ACTG AATTCAG G CCCTG G G AACTTTAAATTTCAA
TCCTATCTCC[T/C]CTGCTTGACCACAGTGCTCACAGATAGGACCGTGTTT TTGTTGTGAACTTAATTACACAC
96 D3J03840114 GCAATGCTTCATTGTGGTTATTCCAGAGAAGACAGAGCAATCCAAGCCAC
CCCACTGATG[T/C]TCAGGAACAGGTCAACCAATTCATTTGGGGGCACAG CGTATCCTTATCCGTGCCACACCG
97 D3J22502120 AATAAGAGACTGCATTTCATTGAATCCTCTTTGAACCCGTTTTGCTATTCC
AATAAAGAG[A/C]CCTGCAAGTCCTGATTTCTCTGGAAAATGAATAATAATC TTCTAATTTGTTGTTTCCTCA
98 D3_24565823 TTTATGGAATGGAAGATGAACCTTGATGGATGATAAAGCATGTCATGAAA
GTGGATGCAC[A/G]GAAGGCCAGAATTCTTCAAGTTCACAAGAACCTGAC CAGCGCAGTGACTTCTTTATGTAC
99 D3_24823793 TGGTCTCATGGCTGAGTCAGCACCTGTGCAGAGGCGCAGAGGCACTAGA
CTTCTCCCACT[C/G]GTTGCATTTAACTGAGGGGACACAGCCTGTGTGCTT CCTGTAGGGAACAGAACAAGTAAA
100 D3_28838660 CACACAGGCATAGCCAGAAGAAGGCAGCCAAGCCAGATGCTGGACCAGA
CTCCACAGTCT[T/C]CTGGAAAATCATGAGTTGAAAAGGAAACCCTTAGCC ACCATATAATCTTGTGGCTTAGTA
101 D4_41078218 TAGCTGACTTTAATTCTCCCACAAAGAGAGGAAATTAGCCACATTATTTTA
AAAAGAGAT[T/G]CTTCATTTTACAAAAAGATTGCTGAACATTTCCTAAATG ACAATAG GACATTCAAAAAAT
102 D4_42000379 TTCCAGAGTGACGAGGACGCATAGTCGCTGCCCAGAGAAGATGAAGCAC
TCTGGAGAGAT[C/G]AAAGGCCATTGAGGCCTGAGTGGCTGTACAATTTA GCACTGGGGGTTCTATTCAGCAGTC
103 D4_63622083 CCTCAATGTATGGTGGTGGCTGAAAAGCTGTTGCAGCTTCATGCCCAGAA
ATGCACGTGT[A/G]TACATGAATACATGGGTTTGTGGATGGATTTTGCATG AGTGCATATGTGGGTCTGCATGT
104 E1_130875919 CTGCGTGACTGTAATTTTCCCCTTGAGCCCTGGATACAAATAAAGAGCCA
GCTAATACTT[T/G]CTTTGCCCTTTTTCTACTCTCCCTTTGCTTAACCCACA GGTATTTACAAGGTTTTGGTTG
105 E1_3912105 GTGAGTAACATGGTCCACATACCCATGGAATGGGTGTCCTGAACAAGGTC
TGGGCAGTAG[T/G]TGACAATGAACTGAAAATAAGTGGAGTCATTTCCATG ACCGTAATGATAACTCTATGATG
106 E1_4114158 TTTTATTTTGTTGATTTAGCGAACATTTATCATGTGCCTTCCATGTGTGTGG
TCCCAAAG[T/G]TGGAGTAGTATTGAATAAGGAGGGCAATTCTGACCCTCA CCCAAG AG G CG GTATG AAG AA
107 E1_48228153 AACAGGAGAGTAGGGCTCATATTGATTAGATATCTGTCACGGGTTGGGAA
GGTTTACCGT[A/C]ACTGTGCTATCCATTTTGCATATCAGTCTTCTGACATG TCCTCTTACATCCATTTTATAG Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
108 E1_48700963 GACGCTTAACCAACCGAGCCACCCGGGTGCCCCTCCTAGGAGGCGATCT
TGAAAAGACAG[A/T]CATAACAGTGCTCCATTATGTGATTTTCAACTTTCTC AGTAAGCATTACAGACTGCCCAG
109 E1_5453028 TCATAAATTCCACCTCCTTTTGCAAAGGACTCCTATGCTTCAGCGTTTCAT
TTTAGATCG[A/G]TAGAATTTAAATTTTCTTGGAATTTTAAAATTCACAGAGA ATCTGGTCTTTTCTTTTAAA
110 E2_22632289 GCAAGATTTGCTTTCCTCTGTATCACCGAGGCAGTTTGCTTCAAAGAACA
ACTATTTG AC[T/C]G GTCAGATG CTACTTGCAGG CAG AG G GG AGTCAAG C CTCAG CACCTTTG G GTG GCACATG
111 E2J4027888 TTTACTTGTAGTATAATAAATGCCATTAGCATGACTAATCACACACCTGATT
AGACAAAC[T/C]GCCCCTCCTCCCCTAGTGTATTTCCTGGATCCTACACCC AATAAATCCAGCATTGATGCA
112 E2_35914023 GGAGGGCAGGGCCTGGTCTTACCCAGTATATCAGAAGCAGCCAGGGTCG
GTCGCCTTCCC[T/C]CCATCAAGTGCTCCCTATGTCCTCCTTGGCTGCATT CTGTGAAAGCACTAGAAGGGAGCT
113 E2_36986631 TTAGGGGAGCAGGAGTTCAGAGACAGGCTTTTCTAAGGACAGGCTTTCAA
AAAAAATGTG[T/G]TTTTTTTGGTTTATTTTACCCTTTTGAAGACCTCACAAC GTATAGTAAGTCACGTCAGGG
114 E2_38860686 AAGCCATGTTGGACGATCTCCAGTCTCTGCGAAAACATGTGACACCATTG
TACATTCCCC[T/C]GGTTAAAACACTTCATTCCCAGTTTTATTGTGTTGCCT GTGGCCCCTTACTTTTGAGGCT
115 E2_65436639 TCTGGGGGACGATGGACTCAGGAGGGGACCTGAGAAGTATGTAGGAGAA
GGCAGGCTAAC[A/G]AAAGGAGGGAGAGTCAGCCGAGTACCAGAGGTGG GG GCAGAG AG G CTCAGTG AGG GAG CC
116 E2_7950477 TACATTCTAGTTCAGGATGGAATGAATGAGGGAAAGAAAAAGACGTTTTA
ATTCCTCAAG[T/G]CTTTCTGGTGTGCAAGTCCCTTTCTGGGAAAGCACAG GTGCTGGTCGAATTCGTTCCCTG
117 E2_8422942 GCTAATTTCTCTGAGAAATGGCTATGCCATGGGGACCTCCTGCTAAATGC
ATGCAACAGA[A/G]TATTCTAGAAGCATGCTAAAATAGATTCAGGGTCCCA TGCCAGCCCACCTGGGCTTGCTA
118 E3J6044809 CAGTTAGTAAGCACTCCTTTGGTTAGTACAGAAAAAGTGAAATGTTGGAG
GTGTGAGAAA[T/C]GCGGTTGGGGGCATGTTGAAGGACAGGGACACGCG CTTTGTGACTGCCAGGTTTTGAGAG
119 E3_55434272 TGCCGCTTCAGATTGGGGAGACAGGTTCAAGGTGACTGCCTCAACATAC
CCAAGTTCAGA[A/G]GGAGGAGCTCCGATCATACACTGTGTCTTCCCCGT GACACCACATGCCCTGCCCCTGAGG
120 F1_20309325 TCTGTGGAGGTGATGTGACAGCCAGGGCACTGTTGTCACCCAGAGAATA
CAGGCATTTGG[A/G]ACTGCTATTAAATCTACTGAAAGCCAGTCACTGCAG AAGAAGGCAAGCTATAGGCCTGCT
121 F1_21799641 TGACCCAGGGTCAAATTTGGTGGCCTCTTCCTTAGCGGTCAGCTTAGCAG
TGAAGGTCTG[A/G]CACATGCTTCCACAGCACATGCTTCGATAAGTGGCTA ACGAAGAAATGAATAAAAGAGCT
122 F1_26100599 CCAAAAGAAACAAAACTGCCAAGTAAAATTGCACTCCAAGAACTGGGCAT
ATGCTTTATT[A/T]ACCCAAACCTCATGTTTATAAGACTCAGTACCGACTCT AATTCAGGCTAGTGGGTCACAA
123 F 1 _27124984 CACATTATTTGTCTGTTCCCACATGATCTCAATGAATGTAAATTCCTTTCAT
CCTGAAGT[A/G]GCCAGTAAGAACACACTCTTCCAGTGAGGCTCCCTTCCT TCAGACCTTTCTGATTTGCAC
124 F1J8051725 CTTTACAACGAAGAGGTACACATTGCTAATGGGAGTCACAGTACGGTGTG
GGCAAAGGTT[A/G]ATTTTTTCTTAATTCTTGTAGAGGCGCCAAAAAGTACA CACAACTCCTACTCAAGTTCAC Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
125 F1 565223 TGAGAGTTTGGACTTGAGGTATCCTCGTGTTAAAAACGTAGACATTGGTG
TTTCGAAATG[A/G]TGGGAGAATCAGACATTGAATATAGTCAACGCGTTGT AAATTAACATTTCCTTCTAGTTG
126 F1 82716202 CTCCTTTTCCAATCTCATCTCTTATCAACTCTTTCTATGCACCTTATATTCA
GGCTATAC[T/G]GAATTACTGGTGGTAGCCTGAAATGCTGACCTCTTTACT GGAATACCACCTTTTCCTTAT
127 F1_91517402 TGCTTATCCACCTAATAATATAATTCAGTAATAGCAATACAAAAGTATGATC
TTTGTTTG[A/G]TCCCGATTCACACAACCCAACTGCAAAAAGACCGTTGAG GATATTTGGGTGCTTACTGGA
128 F2 26886470 TAACCTAAAAACGTACAGTGGGAATGCACGAGTACCCAGCAGTGCTTCAG
GCAATGCGTG[A/G]CTTGTTAGTTTGCTATGTTTGGGGACAGATTCTTAAT
GTCCTCAAATAAAATTCCAGATA
129 F2 38395360 AAGACAGCTACATTCCAGAGGATCCAATTTTGCCTTGTAGAGTATAGACAT
CCATGGCAC[A/G]GGCCTTGAAATAGCCCAGCAGGGGGAATGGTTGAAAC TCCAGGAGCTGTGCCTTTATAGA
130 F2_46855978 TTCCTTTTATGGCCTGGAGAAGGTTTTCTAACTTTCCGCTACATGCCATCC
GGTCTGGTA[T/C]AACTGACGAAAACAATTGTTGAAAGTACTGTCCTCTGG TTAAATAAATTATGGTACGTCT
131 F2 74863327 TGACTGCACTTCCTTCTGAGCTGGAGGAGGGGCATACAATGCACCCACT
AACTAGGTATG[T/C]GATTCCCGGTCCATCAGAACCTGCATTCCCACCAGC
ACCTTAGCCCCTCTCCACGTTCTC
132 F2 78303221 AAAGTGTCATCGATGCCCAAACCACGACTGATGAAGGATGGGAATCAAAT
CGTCTGTCTT[T/C]GTAGAGGCCACCAATGGTACTAACCACGCTGGAAAC
GAACGCCTGTTGGTTAAATGTACA
133 F2_79632602 CCAGTGTACCTTTTGGTAACCATTTGCATGGGTGTTTTGCTGCATTAGAAC
ATGTGAGTC[C/G]CTCTAGCACTTGTGTGCGGGAATCCCACCACCAGGAT
AATCTGGAGGTCATGTTACGGAG
134 F2_8427817 ATTTTGTCACGTAAGCAACACTGGAATTCTGAATGTGTGTTCGCAGGCGC
TCACATAATT[A/G]CCAACTGTGATTTTAGACGAGCCTGTGCCTCGGATCC CAATATTATTTATCATGCACGTT
135 C2 187325 AATCCTAACATTCATTAAAAGGAAACTGTAAGCCGCGACCGTGTGAGATC
ACGTGCTTCT[A/C]GATTTACAAAAGAATTCTAGTCCTTCAGCAGCTGTTTA AAAGTACTTTTAACTAACTAAA
136 D2_717969 aCAGATATTCTTTTTTATAGCCTTTTACTTATTAGAAGAACGATAGGTACTC
GTGATACT[A/G]CGTTTTGAGCTCTGAGAAGATACGTAGAATCATTAAGTC ACCGGGGGTAACTGTCGTCAG
137 B4J687419 CTCTTGCTGCCCTAAAGGTGGACTGAAAATGGAGTTGGGTGATCATCCCC
AGTGGATGCT[T/C]GTAGCACTTAGCTCATGATATGTGCTCTATAAATATCA GCCTTTATAAATTATTAGTGCT
138 D3 1810839 ACTTAACCCAGGGAATTCTTCCAGGAAGCACTTCAGAAAATGGAAAGCAC
CACATGGCAG[T/G]TTTCTTCTGGGTTTAAAAACTGCTATTTGCGGGTACC TTTGTTTGTATTTTCAAGCAGGA
139 A3_11480952 AGAACATTGACCTTGAATGCATGCAGTTTAGGAAGTGAAGGCCAGACCAC
CAAGGAGGCC[T/C]ATGTTGGCTGTGTTTTCACATCTTGCTTCCCCTGGGG AAACCAGGGCTGGGGCAGGAAGG
140 D1J6242433 GGTTTCTGGAAGTGCAATTCCTCAATATCCTGCCTCCCAACCAGGTAGGC
AG G AG AGG AA[A/G]ACCTAAAATCTG CTG AATTACTTTCTTGAATTTG G CC TGTTTTCCAGGCTGTCTACTATG
141 E2 39211557 ACTAACGTCAAGACCCGTCTGCATCCCGAGGACAGGAAATAAGCAACTCT
GTGCATTTGC[A/G]CAAGACCTTGCGGAAGACCTCATTACAGACGAGTGG
ATGTTTGCCCATCAAGCTCTTTGT Table 1 - SNP sequences useful for breed identification test
SEQ ID NO: SNP ID Sequence
142 E3 67006512 CCCGGACGGCCCACTGTGAAGTTCTGCCCCGCATGTCCCTGAGCGTCAT
CCACCACCTG A[T/C] CAG CTCATAATAG AG CTG G ACTCCCCAG CACTCCG GCATCCCTCCCCCTCCCACCTGGGA
143 F2 68572596 AGCTATTGTTCCAATAAAATTACTTCCTAAAACTGCACTCAAATTTCAATTT
ATCCCATG[T/C]GAATCTATTCAGCAATTTCCCCAACTTCTCTTAGCTGTCT GAAACCTCCTTTTCATATTT
144 F1_82068276 CTGTAGTAACATTCCATAATGAGAATATGAGATTATTCCGGATAGTCATAG
ACACAAGAT[A/C]CACTACCCTTCAGTCCCTGATAAATGCTCAGTGTCTGT GGTTTCCCTTCCATTATTATTT
145 E1 131587399 TCG CTG CTGG ATG G CTG ACG GTTTTTCAAAACCTGCAG AAAGAAACAAAG
TTAGTTCTAA[T/C]CACACACTGGAAGCTCCTCGGTATCCCTGTTTAAGCC CTCACCCCCACCCCTCCTAACCC
146 B4 147206961 CCCCGATGTGGAAATGCTAGCTTGGGGCCCAAGTCTCTGTCTTAAGGGT
AACAGGGAATG[A/G]TGTCTAGAAAGGACCTTGTGCCAAATGGCTGTGGC ACATGCCATAAGGCATCCAGGTTGA
147 C1_181852965 CCTTCCTGAATTCTCTGCCCTCCCGTTCCTGCACCATTGAAATCCAGAGG
GCATAAGTTC[A/G]TGAAACTAATAGCAAGTAGAGCGGCATAAACAGAAAT AGTTCTTACTATAAATG GAG CCT
148 C1 216852686 GTTAGATTCAGGGAAATTTGCATGACCTGCCCGAGCTCAGTCTTCTGAGT
GAAATGGAGA[T/C]CGTCACGAGGATGGAGTTGGCTCATGTGTGTGCATG TGCTTGTCAGCCTGTATACACCCA
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Figure imgf000039_0001
Allele Allele
chrAU 0141047 A G 0.146 0.088 0.175 0.286 0.000 0.036 0.063 0.000 0.107 0.000 0.042 0.000 0.458 0.028 0.000 0.094 0.045 0.063 0.125 0.08 chrA1_133621071 C T 0.270 0.315 0.245 0.167 0.769 0.367 0.528 0.526 0.667 0.079 0.500 0.467 0.643 0.316 0.045 0.250 0.065 0.316 0.406 0.41 chrA1_151648701 G A 0.065 0.086 0.055 0.267 0.231 0.100 0.000 0.000 0.028 0.000 0.000 0.000 0.036 0.079 0.154 0.000 0.000 0.079 0.176 0.32 chrA1_175780586 G A 0.394 0.572 0.306 0.500 0.400 0.933 0.563 0.421 0.750 0.750 0.500 0.667 0.773 0.583 0.545 0.528 0.618 0.656 0.533 0.50 chrA1_208054462 C G 0.129 0.185 0.102 0.393 0.150 0.000 0.156 0.083 0.235 0.028 0.346 0.167 0.214 0.194 0.000 0.118 0.045 0.263 0.206 0.12 chrA1_22350114C A G 0.133 0.193 0.099 0.533 0.083 0.100 0.344 0.475 0.083 0.083 0.063 0.000 0.321 0.176 0.818 0.000 0.000 0.237 0.235 0.05 chrA1_223506906 A G 0.260 0.123 0.327 0.533 0.000 0.042 0.100 0.000 0.000 0.000 0.417 0.423 0.000 0.079 0.000 0.167 0.025 0.194 0.029 0.13 chrA1_22505793 C A 0.233 0.128 0.283 0.400 0.038 0.067 0.139 0.375 0.028 0.132 0.250 0.233 0.115 0.026 0.038 0.417 0.060 0.053 0.265 0.02 chrA1_23557953£ G A 0.101 0.027 0.138 0.033 0.000 0.000 0.000 0.000 0.000 0.028 0.000 0.067 0.000 0.026 0.000 0.000 0.025 0.031 0.063 0.06 chrA1_27523501 C A 0.564 0.473 0.605 0.233 0.308 0.714 0.500 0.850 0.406 0.342 0.231 0.000 0.536 0.333 0.458 0.235 0.682 0.412 0.441 0.47 chrA1_68485376 A G 0.059 0.089 0.045 0.000 0.385 0.000 0.000 0.000 0.000 0.000 0.200 0.071 0.000 0.194 0.227 0.167 0.000 0.206 0.188 0.08 chrA1_69424718 C T 0.378 0.311 0.410 0.100 0.154 0.393 0.265 0.289 0.194 0.395 0.409 0.467 0.400 0.500 0.192 0.235 0.550 0.105 0.412 0.35 chrA1_7429296 C T 0.181 0.152 0.196 0.200 0.154 0.133 0.382 0.000 0.194 0.056 0.167 0.633 0.077 0.028 0.100 0.111 0.000 0.313 0.265 0.03 chrA1_8742286 G T 0.373 0.278 0.416 0.067 0.346 0.167 0.000 0.650 0.278 0.447 0.292 0.667 0.000 0.026 0.583 0.368 0.208 0.278 0.313 0.41 chrA2_152258936 T C 0.386 0.401 0.382 0.233 0.417 0.154 0.056 0.194 0.389 0.353 0.231 0.433 0.036 0.079 0.708 0.235 0.370 0.316 0.412 0.33 chrA2_201526186 C T 0.191 0.211 0.182 0.393 0.154 0.286 0.056 0.025 0.083 0.105 0.042 0.067 0.654 0.316 0.042 0.553 0.160 0.361 0.294 0.27 chrA2_20222577C C T 0.327 0.363 0.311 0.000 0.167 0.077 0.222 0.278 0.306 0.342 0.500 0.767 0.333 0.667 0.591 0.147 0.553 0.250 0.382 0.32 chrA2_44241149 G T 0.016 0.008 0.019 0.000 0.000 0.000 0.000 0.200 0.000 0.000 0.000 0.000 0.038 0.000 0.000 0.000 0.000 0.000 0.000 0.00 chrA2_554046 T C 0.149 0.122 0.165 0.700 0.000 0.033 0.531 0.000 0.056 0.026 0.115 0.000 0.538 0.000 0.125 0.158 0.040 0.316 0.000 0.00 chrA3_10142006£ T G 0.052 0.055 0.049 0.033 0.000 0.033 0.029 0.200 0.000 0.342 0.000 0.000 0.417 0.000 0.000 0.000 0.000 0.000 0.059 0.25 chrA3_11480952 C T 0.025 0.024 0.026 0.000 0.083 0.292 0.000 0.000 0.028 0.000 0.000 0.000 0.000 0.000 0.000 0.026 0.000 0.053 0.100 0.00 chrA3_12082294 G A 0.212 0.288 0.178 0.533 0.731 0.714 0.139 0.000 0.278 0.079 0.375 0.200 0.179 0.500 0.000 0.278 0.000 0.158 0.643 0.25 chrA3_130195244 T C 0.188 0.184 0.188 0.643 0.136 0.536 0.393 0.306 0.000 0.237 0.083 0.000 0.389 0.079 0.150 0.417 0.000 0.219 0.125 0.16 chrA3_15953763 G C 0.471 0.316 0.552 0.200 0.423 0.033 0.559 0.225 0.361 0.132 0.250 0.214 0.429 0.263 0.038 0.658 0.060 0.579 0.500 0.12 chrA3_162208567 C G 0.265 0.374 0.206 0.333 0.500 0.107 0.500 0.889 0.594 0.031 0.318 0.577 0.393 0.658 0.083 0.176 0.000 0.412 0.469 0.53 chrA3 38781591 G A 0.013 0.020 0.010 0.167 0.000 0.133 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.02
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
2. . S ro
Major Minor
Figure imgf000040_0001
Allele Allele
chrA3_75156179 G A 0.240 0.228 0.249 0.533 0.462 0.433 0.029 0.000 0.029 0.000 0.000 0.000 0.115 0.026 0.192 0.222 0.042 0.583 0.250 0.44 chrA3_91058022 A C 0.286 0.391 0.237 0.667 0.538 0.038 0.265 0.025 0.361 0.194 0.000 0.000 0.643 0.211 0.077 0.444 0.304 0.711 0.735 0.75 chrA3_99507784 A T 0.324 0.251 0.356 0.071 0.192 0.367 0.088 0.625 0.147 0.342 0.042 0.033 0.625 0.158 0.077 0.500 0.435 0.206 0.188 0.20 chrB1_10420438 C T 0.074 0.117 0.054 0.000 0.038 0.615 0.156 0.025 0.083 0.000 0.083 0.333 0.038 0.333 0.045 0.000 0.000 0.000 0.059 0.05 chrB1_12214271 T G 0.432 0.413 0.438 0.500 0.250 0.100 0.265 0.842 0.389 0.289 0.222 0.600 0.231 0.471 0.115 0.526 0.182 0.421 0.441 0.22 chrB1_195678303 T C 0.181 0.139 0.201 0.067 0.038 0.714 0.250 0.132 0.000 0.263 0.000 0.067 0.115 0.053 0.364 0.079 0.080 0.053 0.088 0.11 chrB1_199564532 G A 0.091 0.119 0.078 0.633 0.115 0.000 0.324 0.000 0.028 0.000 0.000 0.000 0.538 0.139 0.038 0.139 0.042 0.000 0.088 0.14 chrB1_202966562 C T 0.274 0.353 0.236 0.200 0.250 0.467 0.176 0.395 0.441 0.500 0.591 0.700 0.538 0.368 0.000 0.333 0.326 0.406 0.265 0.20 chrB1_54775572 G A 0.119 0.125 0.118 0.933 0.000 0.167 0.028 0.000 0.278 0.000 0.292 0.000 0.036 0.211 0.000 0.222 0.000 0.184 0.029 0.08 chrB1_80161671 G A 0.151 0.210 0.126 0.567 0.192 0.000 0.188 0.000 0.625 0.079 0.300 0.036 0.192 0.469 0.000 0.000 0.000 0.406 0.344 0.42 chrB1_88148379 T C 0.395 0.353 0.420 0.467 0.385 0.036 0.556 0.075 0.588 0.000 0.292 0.033 0.786 0.222 0.292 0.118 0.409 0.441 0.353 0.32 chrB2_13831248£ G A 0.452 0.447 0.449 0.100 0.038 0.900 0.000 1.000 0.306 0.816 0.636 0.133 0.125 0.421 0.083 0.167 0.840 0.389 0.281 0.67 chrB2_14666065C C T 0.019 0.035 0.012 0.100 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.026 0.000 0.000 0.271 0.000 0.000 0.00 chrB2_41509834 G A 0.380 0.378 0.378 0.067 0.308 0.923 0.118 0.447 0.179 0.861 0.318 0.286 0.000 0.139 0.077 0.605 0.979 0.139 0.063 0.13 chrB2_45093345 A G 0.364 0.406 0.344 0.786 0.583 0.154 0.200 0.263 0.559 0.028 0.409 0.654 0.077 0.658 0.125 0.088 0.261 0.667 0.618 0.53 chrB2_6949528 G A 0.126 0.151 0.115 0.767 0.038 0.067 0.056 0.083 0.167 0.000 0.038 0.333 0.083 0.421 0.000 0.083 0.000 0.211 0.176 0.21 chrB3_10448397C G A 0.324 0.324 0.318 0.233 0.000 0.533 0.222 0.900 0.083 0.842 0.250 0.200 0.269 0.026 0.923 0.441 0.783 0.167 0.147 0.05 chrB3_111000326 A G 0.191 0.123 0.225 0.300 0.000 0.267 0.000 0.075 0.118 0.263 0.042 0.067 0.038 0.053 0.458 0.000 0.180 0.026 0.000 0.00 chrB3_13666494 C G 0.491 0.560 0.454 0.567 0.583 0.833 0.472 0.625 0.500 0.868 0.269 0.900 0.077 0.722 0.846 0.676 0.813 0.611 0.382 0.35 chrB3_39203469 G A 0.215 0.128 0.259 0.000 0.308 0.200 0.028 0.000 0.088 0.028 0.083 0.167 0.000 0.263 0.000 0.118 0.023 0.139 0.063 0.20 chrB3_51317931 C T 0.304 0.322 0.293 0.571 0.038 0.433 0.000 0.471 0.000 0.737 0.385 0.167 0.000 0.053 0.846 0.083 0.978 0.088 0.147 0.08 chrB3_57141954 G C 0.285 0.394 0.234 0.000 0.667 0.167 0.000 0.100 0.444 0.026 0.409 0.000 0.692 0.611 0.125 0.412 0.000 0.694 0.588 0.59 chrB3_77094074 A C 0.082 0.135 0.060 0.033 0.231 0.364 0.206 0.031 0.250 0.088 0.150 0.192 0.091 0.200 0.050 0.067 0.000 0.361 0.094 0.10 chrB4_105706694 T C 0.456 0.427 0.464 0.067 0.462 0.077 0.639 1.000 0.471 0.471 0.458 0.500 0.818 0.528 0.550 0.324 0.457 0.324 0.324 0.50 chrB4_142658074 A G 0.137 0.175 0.115 0.600 0.045 0.143 0.233 0.553 0.265 0.026 0.273 0.071 0.167 0.088 0.000 0.412 0.000 0.053 0.206 0.33 chrB4_143006494 A G 0.254 0.220 0.273 0.000 0.808 0.100 0.500 0.000 0.059 0.059 0.045 0.067 0.154 0.147 0.222 0.618 0.000 0.206 0.469 0.53 chrB4_14469330£ G A 0.390 0.401 0.380 0.385 0.773 0.667 0.367 0.947 0.194 0.889 0.292 0.321 0.107 0.158 0.636 0.206 1.000 0.324 0.529 0.21 chrB4_146486982 T C 0.278 0.273 0.282 0.750 0.000 0.786 0.029 0.025 0.133 0.737 0.125 0.033 0.154 0.053 0.700 0.278 0.896 0.111 0.088 0.00
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Figure imgf000041_0001
Allele Allele
chrB4_147206961 T C 0.382 0.446 0.354 0.679 0.050 0.750 0.194 0.235 0.115 0.778 0.450 0.600 0.273 0.143 0.808 0.321 0.896 0.208 0.235 0.20 chrB4_149532846 C T 0.074 0.125 0.050 0.767 0.000 0.071 0.406 0.000 0.333 0.000 0.042 0.036 0.107 0.053 0.000 0.281 0.042 0.194 0.118 0.08 chrB4_1687419 C T 0.057 0.024 0.077 0.000 0.000 0.000 0.031 0.000 0.028 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.056 0.031 0.29 chrB4_20001848 T C 0.030 0.058 0.018 0.433 0.038 0.107 0.382 0.000 0.000 0.028 0.000 0.000 0.045 0.000 0.000 0.028 0.000 0.412 0.000 0.05 chrB4_21098349 C T 0.406 0.479 0.376 0.750 0.708 0.300 0.375 0.125 0.844 0.389 1.000 0.607 0.182 0.567 0.077 0.447 0.000 0.618 0.781 0.67 chrB4_255106 G A 0.063 0.095 0.047 0.400 0.250 0.000 0.321 0.000 0.029 0.000 0.364 0.250 0.038 0.206 0.000 0.000 0.000 0.088 0.059 0.02 chrB4_3093827 C T 0.132 0.227 0.086 0.333 0.000 0.714 0.444 0.083 0.063 0.526 0.083 0.107 0.000 0.000 0.923 0.000 0.636 0.079 0.059 0.00 chrB4_40319102 C T 0.546 0.478 0.578 0.393 0.167 0.786 0.647 0.421 0.438 0.778 0.000 0.633 0.625 0.559 0.955 0.781 0.222 0.353 0.206 0.29 chrB4_47638578 A G 0.055 0.101 0.032 0.033 0.038 0.000 0.083 0.000 0.278 0.000 0.038 0.000 0.000 0.412 0.000 0.000 0.000 0.250 0.235 0.11 chrC1_11635529E C T 0.272 0.295 0.258 0.167 0.154 0.267 0.118 0.525 0.294 0.158 0.346 0.000 0.042 0.158 0.000 0.184 0.413 0.618 0.647 0.50 chrC1_12316474£ C T 0.217 0.233 0.212 0.923 0.192 0.033 0.600 0.000 0.083 0.158 0.577 0.300 0.538 0.263 0.038 0.000 0.400 0.083 0.063 0.20 chrC1_18185296E G A 0.216 0.301 0.156 0.278 0.417 0.400 0.438 0.115 0.556 0.167 0.214 0.500 0.200 0.542 0.444 0.400 0.029 0.423 0.063 0.16 chrCU 9050213 - G A 0.241 0.146 0.291 0.133 0.231 0.000 0.056 0.025 0.333 0.028 0.900 0.167 0.538 0.194 0.000 0.026 0.000 0.211 0.176 0.05 chrC1_21544157^ C A 0.374 0.430 0.348 0.267 0.154 0.615 0.647 0.118 0.176 0.763 0.417 0.857 0.808 0.605 0.091 0.344 0.455 0.118 0.559 0.25 chrC1_216852686 G A 0.326 0.353 0.314 0.857 0.364 0.214 0.265 0.050 0.324 0.029 0.208 0.000 0.864 0.605 0.000 0.318 0.020 0.531 0.500 0.35 chrC1_24148281 T C 0.202 0.198 0.206 0.033 0.231 0.143 0.147 0.075 0.406 0.053 0.308 0.321 0.036 0.132 0.792 0.000 0.000 0.735 0.382 0.22 chrC1.28702055 G T 0.070 0.091 0.060 0.000 0.077 0.000 0.000 0.000 0.324 0.000 0.038 0.000 0.000 0.026 0.000 0.079 0.080 0.472 0.088 0.28 chrC1_34981315 A G 0.043 0.044 0.043 0.000 0.038 0.067 0.028 0.000 0.000 0.026 0.000 0.000 0.000 0.000 0.000 0.000 0.042 0.000 0.118 0.03 chrC1_396397 G A 0.254 0.269 0.244 0.000 0.292 0.367 0.471 0.579 0.500 0.079 0.273 0.615 0.179 0.447 0.000 0.222 0.000 0.267 0.344 0.32 chrC1.44520932 C T 0.074 0.087 0.068 0.133 0.208 0.000 0.375 0.000 0.118 0.079 0.200 0.000 0.179 0.026 0.000 0.059 0.000 0.000 0.094 0.05 chrC1.52456776 G A 0.477 0.510 0.459 0.000 0.808 0.385 0.438 0.938 0.556 0.467 0.167 0.767 0.393 0.711 0.458 0.692 0.696 0.500 0.469 0.39 chrC2_10699123 - C T 0.278 0.248 0.294 0.100 0.154 0.600 0.250 0.111 0.029 0.816 0.000 0.067 0.071 0.147 0.458 0.053 0.370 0.263 0.235 0.23 chrC2_14712446C T C 0.377 0.327 0.404 0.733 0.115 0.429 0.500 0.079 0.333 0.105 0.417 0.467 0.769 0.105 0.545 0.579 0.021 0.316 0.559 0.36 chrC2_150774106 A G 0.062 0.090 0.049 0.033 0.000 0.000 0.188 0.000 0.028 0.000 0.192 0.000 0.464 0.079 0.000 0.000 0.000 0.167 0.094 0.17 chrC2_15649117E T C 0.479 0.463 0.488 0.250 0.346 0.800 0.500 0.158 0.444 0.722 0.500 0.067 0.071 0.219 0.909 0.618 0.760 0.294 0.294 0.26 chrC2_187325 C A 0.193 0.195 0.192 0.433 0.136 0.464 0.353 0.265 0.029 0.579 0.000 0.357 0.042 0.028 0.727 0.033 0.150 0.059 0.000 0.06 chrC2_262401 G A 0.264 0.299 0.245 0.467 0.083 0.714 0.441 0.350 0.111 0.947 0.000 0.429 0.036 0.026 0.808 0.176 0.913 0.265 0.029 0.03 chrC2_5215469 T C 0.405 0.327 0.436 0.533 0.000 0.633 0.083 0.925 0.059 0.895 0.000 0.107 0.091 0.079 1.000 0.375 0.958 0.088 0.000 0.05
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Figure imgf000042_0001
Allele Allele
chrD1_10132149£ A G 0.315 0.399 0.276 0.700 0.708 0.321 0.036 0.206 0.611 0.053 0.708 0.300 0.385 0.579 0.000 0.222 0.048 0.658 0.500 0.76 chrD1_10494155/ C T 0.119 0.091 0.134 0.267 0.125 0.033 0.250 0.000 0.088 0.026 0.083 0.000 0.077 0.132 0.083 0.139 0.000 0.111 0.059 0.08 chrDU 0549811. T C 0.121 0.144 0.109 0.179 0.042 0.033 0.382 0.083 0.281 0.000 0.462 0.200 0.000 0.342 0.038 0.000 0.020 0.105 0.176 0.20 chrD1_10789012 G A 0.330 0.319 0.339 0.300 0.077 0.433 0.139 0.000 0.333 0.235 0.038 0.100 0.115 0.289 0.308 0.306 0.523 0.588 0.294 0.38 chrD1_11484008 C T 0.138 0.076 0.170 0.133 0.000 0.000 0.038 0.000 0.000 0.026 0.000 0.071 0.107 0.026 0.250 0.235 0.159 0.000 0.000 0.05 chrD1_11752746Σ G A 0.021 0.039 0.013 0.000 0.308 0.000 0.000 0.000 0.059 0.000 0.000 0.000 0.000 0.176 0.000 0.000 0.000 0.237 0.000 0.05 chrD1_12581132£ G A 0.243 0.313 0.205 0.133 0.500 0.233 0.441 0.500 0.222 0.395 0.143 0.333 0.250 0.219 0.500 0.206 0.955 0.214 0.313 0.26 chrD1_12625699 - T C 0.299 0.381 0.259 0.467 0.115 0.321 0.133 0.289 0.265 0.789 0.350 0.200 0.115 0.289 0.923 0.176 0.960 0.088 0.176 0.30 chrD1_126847301 T C 0.086 0.086 0.086 0.033 0.269 0.167 0.029 0.265 0.056 0.026 0.000 0.542 0.000 0.000 0.000 0.375 0.000 0.029 0.038 0.11 chrD1_15984279 A G 0.193 0.213 0.185 0.250 0.538 0.192 0.100 0.059 0.028 0.105 0.577 0.038 0.077 0.053 0.250 0.132 0.214 0.306 0.294 0.33 chrDU 6242433 G A 0.284 0.337 0.263 0.227 0.150 0.650 0.294 0.105 0.083 0.731 0.200 0.455 0.083 0.393 0.417 0.333 0.375 0.344 0.250 0.11 chrDU 8390852 A G 0.148 0.230 0.110 0.733 0.308 0.033 0.031 0.025 0.594 0.053 0.455 0.033 0.107 0.528 0.000 0.000 0.000 0.083 0.471 0.20 chrD1_18570323 A G 0.401 0.370 0.412 0.167 0.385 0.067 0.441 0.842 0.278 0.211 0.455 0.500 0.538 0.316 0.917 0.382 0.600 0.441 0.367 0.33 chrD1_66177762 G A 0.101 0.121 0.091 0.167 0.308 0.000 0.056 0.000 0.222 0.026 0.269 0.033 0.429 0.132 0.000 0.079 0.000 0.447 0.294 0.19 chrD2_1020904 A G 0.466 0.336 0.531 0.100 0.346 0.500 0.471 0.150 0.194 0.711 0.038 0.214 0.321 0.605 0.231 0.313 0.140 0.389 0.382 0.29 chrD2_10577291£ A G 0.306 0.356 0.275 0.033 0.115 0.538 0.294 0.825 0.167 0.737 0.227 0.067 0.269 0.053 0.917 0.118 0.680 0.056 0.156 0.13 chrD2_1752007 G A 0.131 0.182 0.108 0.333 0.038 0.375 0.111 0.000 0.000 0.342 0.000 0.133 0.000 0.079 0.875 0.235 0.200 0.250 0.029 0.05 chrD2_56777338 C T 0.004 0.013 0.000 0.233 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.040 0.000 0.000 0.00 chrD2_717969 C T 0.404 0.518 0.340 0.633 0.458 0.143 0.382 0.972 0.324 0.737 0.042 0.464 0.269 0.194 0.958 0.583 0.913 0.500 0.235 0.40 chrD2_74293444 C T 0.195 0.191 0.197 0.000 0.167 0.071 0.029 0.158 0.056 0.158 0.000 0.615 0.731 0.194 0.227 0.056 0.208 0.139 0.313 0.32 chrD2_91989307 G A 0.066 0.100 0.050 0.467 0.000 0.367 0.028 0.000 0.000 0.000 0.154 0.100 0.000 0.105 0.833 0.147 0.000 0.056 0.094 0.05 chrD3_1038401 C T 0.042 0.054 0.036 0.100 0.038 0.033 0.000 0.000 0.056 0.000 0.038 0.000 0.269 0.000 0.000 0.000 0.000 0.000 0.000 0.00 chrD3_12250212C G T 0.230 0.184 0.248 0.467 0.038 0.346 0.028 0.694 0.029 0.278 0.182 0.357 0.000 0.211 0.292 0.125 0.786 0.056 0.156 0.18 chrD3_1810839 T G 0.349 0.405 0.319 0.923 0.545 0.250 0.179 0.167 0.471 0.278 0.350 0.714 0.458 0.500 0.000 0.300 0.000 0.767 0.600 0.69 chrD3_24565823 G A 0.081 0.156 0.044 0.367 0.423 0.100 0.028 0.000 0.559 0.000 0.231 0.233 0.000 0.184 0.000 0.000 0.000 0.289 0.324 0.35 chrD3_24823793 C G 0.193 0.132 0.224 0.000 0.038 0.133 0.000 0.225 0.028 0.342 0.269 0.500 0.000 0.079 0.818 0.079 0.326 0.026 0.059 0.05 chrD3_28838660 T C 0.082 0.139 0.053 0.000 0.000 0.000 0.000 0.447 0.000 0.389 0.042 0.267 0.000 0.000 0.077 0.083 0.800 0.000 0.000 0.00 chrD4_41078218 A C 0.448 0.430 0.456 0.071 0.500 0.083 0.406 0.579 0.125 0.206 0.364 0.821 0.417 0.605 0.364 0.567 0.412 0.658 0.536 0.32
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
2. . S ro
Major Minor
Figure imgf000043_0001
Allele Allele
chrD4_42000379 G C 0.081 0.106 0.069 0.000 0.000 0.536 0.441 0.000 0.033 0.395 0.000 0.000 0.042 0.000 0.000 0.000 0.000 0.000 0.125 0.15 chrD4_63622083 G A 0.138 0.198 0.111 0.308 0.750 0.100 0.000 0.083 0.176 0.056 0.500 0.633 0.179 0.353 0.000 0.028 0.022 0.028 0.375 0.36 chrE1_13087591£ C A 0.125 0.134 0.123 0.038 0.269 0.033 0.000 0.000 0.111 0.000 0.038 0.600 0.375 0.079 0.000 0.324 0.000 0.406 0.206 0.40 chrE1_13158739£ G A 0.089 0.143 0.056 0.071 0.385 0.536 0.100 0.500 0.528 0.000 0.450 0.100 0.036 0.211 0.154 0.028 0.000 0.184 0.000 0.19 chrE1_3912105 G T 0.170 0.249 0.132 0.467 0.375 0.143 0.111 0.147 0.417 0.079 0.778 0.200 0.143 0.237 0.000 0.029 0.109 0.306 0.176 0.26 chrE1_4114158 g t 0.477 0.499 0.467 0.400 0.417 0.433 0.083 0.000 0.056 0.316 0.000 0.300 0.500 0.000 0.731 0.105 0.521 0.063 0.094 0.02 chrE1_48228153 C A 0.218 0.254 0.202 0.400 0.417 0.433 0.083 0.000 0.056 0.316 0.000 0.300 0.500 0.000 0.731 0.105 0.521 0.063 0.094 0.02 chrE1_48700963 A T 0.062 0.093 0.048 0.733 0.000 0.143 0.088 0.000 0.111 0.000 0.000 0.100 0.077 0.056 0.000 0.000 0.000 0.278 0.294 0.20 chrE1_5453028 G A 0.312 0.352 0.296 0.214 0.731 0.267 0.559 0.000 0.353 0.000 0.231 0.200 0.679 0.474 0.192 0.444 0.020 0.278 0.600 0.66 chrE2_22632289 G A 0.439 0.411 0.449 0.750 0.731 0.385 0.688 0.861 0.382 0.079 0.308 0.115 0.346 0.441 0.708 0.389 0.545 0.184 0.206 0.25 chrE2_34027888 G A 0.082 0.155 0.044 0.000 0.125 0.038 0.031 0.447 0.528 0.237 0.462 0.300 0.083 0.694 0.000 0.026 0.000 0.028 0.250 0.08 chrE2_35914023 C T 0.215 0.195 0.226 0.700 0.417 0.033 0.028 0.000 0.118 0.026 0.038 0.200 0.143 0.000 0.038 0.563 0.043 0.056 0.688 0.44 chrE2_36986631 G T 0.435 0.438 0.433 0.300 0.346 0.286 0.353 0.579 0.618 0.361 0.636 0.633 0.500 0.763 0.269 0.400 0.440 0.053 0.500 0.33 chrE2_38860686 C T 0.132 0.188 0.106 0.667 0.423 0.214 0.118 0.000 0.088 0.026 0.227 0.500 0.125 0.222 0.000 0.139 0.022 0.211 0.429 0.25 chrE2_39211557 C T 0.424 0.434 0.418 0.389 0.722 0.000 0.375 0.667 0.542 0.056 0.750 0.583 0.750 0.429 0.083 0.455 0.269 0.533 0.545 0.34 chrE2_65436639 C T 0.277 0.296 0.267 0.567 0.308 0.533 0.222 0.194 0.056 0.556 0.167 0.393 0.321 0.211 0.885 0.105 0.313 0.250 0.235 0.25 chrE2_7950477 C A 0.516 0.518 0.513 0.167 0.750 0.654 0.500 0.639 0.250 0.722 0.346 0.667 0.269 0.676 0.308 0.643 0.550 0.733 0.594 0.41 chrE2_8422942 A G 0.082 0.050 0.098 0.133 0.000 0.000 0.000 0.000 0.000 0.000 0.273 0.214 0.000 0.000 0.000 0.000 0.020 0.028 0.029 0.20 chrE3_36044809 G A 0.374 0.263 0.428 0.100 0.269 0.100 0.088 0.361 0.472 0.139 0.077 0.600 0.179 0.556 0.182 0.382 0.271 0.211 0.118 0.41 chrE3_55434272 C T 0.347 0.361 0.341 0.800 0.417 0.107 0.094 0.200 0.306 0.026 0.462 0.000 0.077 0.441 0.625 0.667 0.217 0.500 0.441 0.30 chrE3_67006512 C T 0.115 0.160 0.093 0.071 0.208 0.033 0.036 0.000 0.536 0.031 0.423 0.536 0.042 0.188 0.000 0.167 0.000 0.235 0.281 0.18 chrF1_20309325 G A 0.085 0.127 0.065 0.367 0.000 0.000 0.235 0.200 0.000 0.278 0.000 0.067 0.375 0.026 0.615 0.000 0.083 0.026 0.029 0.00 chrF1_21799641 C T 0.163 0.230 0.130 0.333 0.077 0.750 0.188 0.150 0.056 0.500 0.250 0.033 0.250 0.158 0.208 0.139 0.000 0.306 0.344 0.37 chrF1_26100599 A T 0.220 0.308 0.180 0.133 0.292 0.167 0.139 0.079 0.433 0.143 0.154 0.308 0.038 0.289 0.292 0.571 0.152 0.237 0.406 0.53 chrF1_27124984 C T 0.316 0.271 0.336 0.367 0.000 0.654 0.361 0.675 0.000 0.158 0.000 0.133 0.429 0.053 0.542 0.294 0.980 0.132 0.118 0.14 chrF1_38051725 A G 0.470 0.448 0.480 0.167 0.308 0.733 0.188 0.417 0.639 0.395 0.538 0.567 0.536 0.417 0.615 0.206 0.500 0.139 0.607 0.47 chrF1_565223 G A 0.496 0.529 0.483 0.107 0.154 0.500 0.676 0.368 0.694 0.684 0.417 0.538 0.821 0.184 0.400 0.471 0.500 0.342 0.471 0.65 chrF1_82068276 G T 0.216 0.361 0.143 0.269 0.318 0.133 0.375 0.139 0.375 0.529 0.682 0.133 0.682 0.357 1.000 0.111 0.900 0.100 0.094 0.17
Table 2a - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Figure imgf000044_0001
o Allele Allele
chrF1 82716202 C A 0.196 0.181 0.204 0.067 0.038 0.067 0.389 0.026 0.222 0.000 0.333 0.067 0.269 0.139 0.000 0.029 0.000 0.395 0.471 0.36 chrF1 91517402 C T 0.188 0.173 0.192 0.467 0.308 0.100 0.133 0.447 0.333 0.079 0.250 0.067 0.077 0.250 0.154 0.105 0.000 0.147 0.235 0.11 chrF2 26886470 G A 0.298 0.322 0.282 0.100 0.115 0.607 0.059 0.650 0.361 0.889 0.417 0.000 0.000 0.361 0.875 0.194 0.739 0.000 0.088 0.05 chrF2 38395360 C T 0.295 0.319 0.285 0.167 0.269 0.357 0.313 0.053 0.778 0.000 0.545 0.607 0.091 0.868 0.045 0.194 0.000 0.278 0.500 0.38 chrF2 46855978 T C 0.329 0.359 0.314 0.333 0.385 0.367 0.156 0.342 0.313 0.441 0.182 0.233 0.357 0.474 0.500 0.316 0.457 0.263 0.375 0.32 chrF2 68572596 G A 0.291 0.241 0.309 0.033 0.115 0.233 0.194 0.912 0.029 0.656 0.077 0.000 0.423 0.158 0.909 0.026 0.471 0.118 0.088 0.13 chrF2 74863327 G A 0.253 0.264 0.249 0.267 0.083 0.567 0.294 0.132 0.206 0.316 0.167 0.200 0.321 0.105 0.682 0.118 0.340 0.053 0.147 0.13 chrF2 78303221 T C 0.475 0.401 0.517 0.600 0.538 0.214 0.412 0.025 0.722 0.028 0.500 0.000 0.750 0.765 0.077 0.579 0.125 0.278 0.647 0.38 chrF2_ 79632602 G C 0.026 0.039 0.019 0.100 0.000 0.000 0.000 0.000 0.111 0.000 0.000 0.200 0.000 0.211 0.000 0.000 0.000 0.028 0.029 0.00 chrF2 8427817 A G 0.402 0.475 0.374 0.692 0.600 0.167 0.154 0.200 0.567 0.500 0.571 0.577 0.222 0.462 0.045 0.750 0.423 0.346 0.500 0.57
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Minor Allele Frequency
o o 73 73 cs> Ό m m
o 03 o o o" U> in o O)' σ o
in in ><
in 3 o co'
in > ro < in o. co'
Major Minor
Allele Allele
chrA1_ 10141047 A G 0.000 0.033 0.000 0.100 0.029 0.000 0.286 0.000 0.000 0.000 0.237 0.294 0.11 0.28 0.31 0.26 0.10 0.04 0.10 chrA1_ 133621071 C T 0.250 0.333 0.600 0.000 0.529 0.000 0.133 0.029 0.000 0.559 0.143 0.184 0.304 0.222 0.309 0.283 0.189 0.316 0.129 chrA1_ ,151648701 G A 0.050 0.067 0.200 0.028 0.000 0.000 0.033 0.500 0.000 0.147 0.026 0.000 0.120 0.063 0.056 0.013 0.027 0.023 0.000 chrA1_ 175780586 G A 0.833 0.400 0.357 0.382 0.794 0.767 0.462 0.563 0.250 0.433 0.333 0.618 0.423 0.410 0.299 0.085 0.088 0.162 0.581 chrA1_ 208054462 C G 0.611 0.200 0.367 0.200 0.294 0.000 0.071 0.000 0.000 0.559 0.190 0.139 0.142 0.138 0.182 0.013 0.014 0.055 0.125
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Allele Allele
Figure imgf000045_0001
chrA1_223501140 G 0.222 0.100 0.067 0.333 0.118 0.267 0.071 0.588 0.000 0.219 0.147 0.075 0.162 0.082 0.074 0.039 0.111 0.167 0.076 0. chrA1_223506906 G 0.000 0.000 0.033 0.000 0.000 0.000 0.091 0.625 0.000 0.179 0.194 0.147 0.154 0.195 0.329 0.367 0.708 0.425 0.183 0. chrA1_225057933 A 0.111 0.067 0.267 0.056 0.029 0.133 0.133 0.000 0.000 0.000 0.190 0.132 0.221 0.218 0.284 0.401 0.000 0.259 0.139 0. chrA1_235579538 A 0.000 0.036 0.036 0.000 0.000 0.033 0.036 0.000 0.071 0.059 0.000 0.132 0.054 0.144 0.090 0.299 0.324 0.125 0.056 0. chrA1_27523501 A 0.150 0.267 0.733 0.735 0.382 0.800 0.667 0.531 0.000 0.406 0.667 0.700 0.426 0.628 0.636 0.745 0.568 0.649 0.786 0. chrA1_68485376 G 0.000 0.107 0.067 0.000 0.118 0.000 0.067 0.000 0.000 0.235 0.053 0.184 0.141 0.076 0.009 0.000 0.000 0.006 0.015 0. chrA1_69424718 T 0.000 0.500 0.400 0.433 0.118 0.367 0.500 0.000 0.143 0.088 0.316 0.556 0.292 0.343 0.332 0.755 0.542 0.335 0.412 0. chrA1_7429296 T 0.050 0.167 0.100 0.000 0.382 0.000 0.000 0.000 0.375 0.533 0.105 0.028 0.183 0.150 0.161 0.244 0.581 0.296 0.028 0. chrA1_8742286 T 0.650 0.033 0.167 0.611 0.000 0.400 0.267 0.031 0.500 0.353 0.250 0.250 0.273 0.406 0.426 0.683 0.257 0.476 0.514 0. chrA2_152258936 c 0.833 0.333 0.600 0.853 0.324 0.333 0.357 1.000 0.714 0.567 0.711 0.361 0.409 0.399 0.319 0.565 0.446 0.314 0.471 0. chrA2 201526186 T 0.050 0.233 0.200 0.000 0.206 0.000 0.133 0.176 0.000 0.412 0.214 0.361 0.207 0.156 0.269 0.161 0.176 0.253 0.103 0. chrA2_202225770 T 0.650 0.633 0.333 0.094 0.324 0.733 0.308 0.107 0.000 0.563 0.300 0.375 0.317 0.319 0.232 0.203 0.108 0.440 0.672 0. chrA2_44241149 T 0.000 0.000 0.000 0.000 0.000 0.000 0.067 0.000 0.000 0.000 0.000 0.000 0.062 0.016 0.009 0.006 0.000 0.017 0.014 0. chrA2_554046 c 0.050 0.000 0.200 0.111 0.059 0.000 0.133 0.000 0.000 0.147 0.150 0.053 0.133 0.169 0.217 0.186 0.027 0.144 0.028 0. chrA3_101420069 G 0.000 0.000 0.000 0.000 0.000 0.000 0.200 0.000 0.000 0.118 0.000 0.000 0.056 0.057 0.065 0.000 0.054 0.087 0.000 0. chrA3 11480952 T 0.000 0.000 0.000 0.000 0.029 0.000 0.067 0.000 0.000 0.059 0.024 0.000 0.053 0.021 0.027 0.000 0.014 0.000 0.048 0. chrA3_12082294 A 0.313 0.467 0.300 0.400 0.406 0.000 0.286 0.833 0.000 0.118 0.071 0.225 0.336 0.171 0.252 0.126 0.095 0.063 0.103 0. chrA3_130195244 C 0.222 0.038 0.100 0.077 0.059 0.167 0.115 0.192 0.700 0.156 0.179 0.059 0.199 0.284 0.368 0.075 0.111 0.124 0.138 0. chrA3_159537633 C 0.050 0.333 0.433 0.222 0.176 0.233 0.367 0.088 0.000 0.344 0.475 0.825 0.472 0.595 0.650 0.699 0.405 0.506 0.243 0. chrA3_162208567 G 0.167 0.786 0.200 0.441 0.794 0.000 0.536 0.100 0.000 0.594 0.382 0.250 0.377 0.194 0.196 0.260 0.068 0.064 0.016 0. chrA3_38781591 A 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.158 0.053 0.022 0.016 0.004 0.006 0.000 0.011 0.000 0. chrA3_75156179 A 0.350 0.000 0.467 0.281 0.118 0.000 0.467 0.233 0.000 0.267 0.333 0.605 0.266 0.375 0.348 0.243 0.068 0.127 0.069 0. chrA3_91058022 C 0.313 0.433 0.633 0.233 0.147 0.133 0.633 0.706 0.786 0.294 0.625 0.342 0.484 0.256 0.241 0.104 0.230 0.106 0.121 0. chrA3_99507784 T 0.100 0.233 0.467 0.333 0.235 0.433 0.033 0.219 0.000 0.176 0.250 0.333 0.231 0.302 0.296 0.578 0.162 0.355 0.456 0. chrB1_10420438 T 0.444 0.267 0.333 0.000 0.125 0.000 0.167 0.000 0.500 0.118 0.071 0.025 0.104 0.082 0.034 0.023 0.027 0.034 0.014 0. chrB1_12214271 G 0.722 0.333 0.533 0.382 0.688 0.267 0.607 0.941 0.714 0.441 0.525 0.105 0.401 0.392 0.591 0.350 0.514 0.554 0.333 0. chrB1_195678303 C 0.056 0.067 0.133 0.500 0.029 0.033 0.143 0.000 0.667 0.088 0.175 0.132 0.102 0.258 0.230 0.358 0.351 0.116 0.071 0. chrB1_199564532 A 0.200 0.067 0.100 0.206 0.147 0.000 0.250 0.000 0.000 0.147 0.095 0.075 0.156 0.101 0.154 0.003 0.027 0.052 0.000 0. chrB1_202966562 T 0.100 0.400 0.267 0.833 0.382 0.167 0.462 0.125 0.000 0.500 0.250 0.316 0.381 0.263 0.198 0.183 0.149 0.184 0.235 0.
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Allele Allele
Figure imgf000046_0001
chrB1_54775572 A 0.000 0.100 0.033 0.059 0.176 0.000 0.000 0.324 0.000 0.059 0.190 0.075 0.188 0.204 0.135 0.059 0.216 0.000 0.097 0. chrB1_80161671 A 0.000 0.231 0.000 0.036 0.594 0.033 0.222 0.583 0.000 0.147 0.056 0.028 0.169 0.096 0.058 0.241 0.068 0.122 0.097 0. chrB1_88148379 C 0.150 0.267 0.567 0.265 0.382 0.500 0.643 0.235 0.333 0.156 0.525 0.605 0.360 0.477 0.483 0.443 0.622 0.369 0.182 0. chrB2_138312489 A 0.400 0.433 0.800 0.433 0.353 0.567 0.400 0.125 0.750 0.735 0.275 0.750 0.422 0.462 0.422 0.282 0.284 0.698 0.700 0. chrB2_146660650 T 0.050 0.000 0.000 0.000 0.000 0.000 0.000 0.467 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.014 0.034 0.139 0. chrB2_41509834 A 0.333 0.233 0.600 0.000 0.000 0.833 0.269 0.857 0.714 0.412 0.605 0.400 0.278 0.257 0.155 0.624 0.351 0.464 0.614 0. chrB2_45093345 G 0.333 0.700 0.500 0.063 0.625 0.067 0.808 0.393 0.100 0.469 0.389 0.474 0.542 0.433 0.404 0.093 0.257 0.227 0.258 0. chrB2_6949528 A 0.000 0.467 0.000 0.083 0.324 0.000 0.214 0.000 0.000 0.029 0.262 0.100 0.201 0.195 0.111 0.029 0.149 0.029 0.014 0. chrB3_104483970 A 0.333 0.133 0.367 0.719 0.000 0.821 0.233 0.471 0.143 0.029 0.050 0.132 0.202 0.328 0.321 0.172 0.122 0.506 0.855 0. chrB3_111000326 G 0.222 0.133 0.033 0.333 0.029 0.567 0.067 0.206 0.000 0.000 0.025 0.100 0.111 0.200 0.261 0.171 0.149 0.333 0.676 0. chrB3 13666494 G 0.667 0.667 0.767 0.563 0.706 0.667 0.286 0.563 0.083 0.353 0.361 0.225 0.475 0.439 0.504 0.255 0.243 0.560 0.765 0. chrB3_39203469 A 0.000 0.200 0.067 0.393 0.147 0.000 0.036 0.000 0.083 0.219 0.333 0.294 0.184 0.378 0.625 0.211 0.108 0.071 0.100 0. chrB3_51317931 T 0.786 0.250 0.233 0.056 0.029 0.893 0.167 1.000 0.125 0.219 0.353 0.325 0.138 0.294 0.276 0.407 0.095 0.390 0.750 0. chrB3_57141954 c 0.350 0.571 0.667 0.882 0.471 0.067 0.533 0.767 0.000 0.531 0.324 0.588 0.377 0.173 0.171 0.242 0.230 0.137 0.069 0. chrB3_77094074 c 0.417 0.036 0.033 0.115 0.467 0.000 0.000 0.000 0.300 0.143 0.105 0.000 0.168 0.006 0.022 0.007 0.139 0.056 0.067 0. chrB4 J 05706694 c 0.056 0.533 0.433 0.344 0.265 0.733 0.286 0.176 0.786 0.500 0.417 0.250 0.374 0.410 0.397 0.480 0.459 0.585 0.371 o. chrB4_142658074 G 0.000 0.200 0.300 0.059 0.353 0.000 0.227 0.000 0.000 0.125 0.167 0.194 0.108 0.190 0.187 0.066 0.014 0.030 0.065 0. chrB4_143006494 G 0.050 0.167 0.733 0.029 0.088 0.000 0.462 0.000 0.000 0.469 0.105 0.139 0.338 0.344 0.345 0.243 0.097 0.110 0.074 0. chrB4 144693308 A 0.625 0.167 0.133 0.156 0.029 0.833 0.367 0.333 0.750 0.406 0.190 0.289 0.311 0.426 0.460 0.450 0.473 0.335 0.469 0. chrB4_146486983 T C 0.050 0.033 0.067 0.528 0.156 0.767 0.269 0.433 0.000 0.029 0.200 0.075 0.193 0.194 0.124 0.288 0.541 0.134 0.641 0. chrB4_147206961 C 0.556 0.179 0.292 0.719 0.000 0.900 0.500 0.938 0.917 0.222 0.294 0.100 0.350 0.276 0.434 0.293 0.176 0.544 0.750 0. chrB4_149532846 T 0.200 0.000 0.233 0.000 0.324 0.000 0.115 0.063 0.000 0.067 0.000 0.025 0.126 0.056 0.030 0.016 0.014 0.023 0.057 0. chrB4_1687419 T 0.000 0.000 0.000 0.000 0.000 0.000 0.115 0.000 0.000 0.063 0.000 0.029 0.108 0.141 0.145 0.013 0.000 0.009 0.000 0. chrB4_20001848 c 0.000 0.000 0.000 0.000 0.063 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.046 0.008 0.000 0.003 0.000 0.029 0.029 0. chrB4_21098349 T 0.350 0.500 0.808 0.250 0.923 0.000 0.462 0.281 0.000 0.647 0.737 0.475 0.581 0.408 0.375 0.359 0.357 0.318 0.118 0. chrB4_255106 A 0.050 0.200 0.067 0.000 0.147 0.036 0.000 0.133 0.071 0.000 0.071 0.105 0.120 0.025 0.065 0.036 0.000 0.006 0.015 0. chrB4_3093827 T 0.400 0.033 0.000 0.900 0.088 0.800 0.000 0.219 0.000 0.063 0.000 0.000 0.109 0.046 0.055 0.000 0.041 0.071 0.452 0. chrB4_40319102 T 0.688 0.643 0.767 0.000 0.412 0.867 0.467 0.813 0.500 0.118 0.316 0.368 0.468 0.470 0.600 0.500 0.730 0.560 0.818 0. chrB4_47638578 G 0.100 0.367 0.067 0.000 0.559 0.000 0.115 0.000 0.000 0.029 0.048 0.026 0.086 0.038 0.004 0.006 0.000 0.017 0.014 0.
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Allele Allele
Figure imgf000047_0001
chrCU 16355295 C T 0.500 0.233 0.200 0.000 0.500 0.500 0.300 0.265 0.000 0.206 0.350 0.667 0.332 0.262 0.272 0.203 0.284 0.320 0.235 0. chrC1_123164748 C T 0.150 0.167 0.067 0.000 0.088 0.000 0.467 0.588 0.000 0.059 0.389 0.275 0.261 0.237 0.196 0.267 0.000 0.229 0.242 0. chrC1_181852965 G A 0.500 0.400 0.500 0.125 0.417 0.125 0.167 0.591 0.000 0.308 0.136 0.000 0.406 0.108 0.167 0.022 0.000 0.113 0.056 0. chrC1_190502133 G A 0.300 0.133 0.000 0.139 0.235 0.133 0.067 0.000 0.000 0.000 0.200 0.275 0.176 0.381 0.293 0.576 0.306 0.215 0.028 0. chrC1_215441574 C A 0.056 0.700 0.367 0.118 0.265 0.200 0.462 1.000 0.125 0.588 0.206 0.583 0.394 0.346 0.272 0.235 0.459 0.323 0.574 0. chrC1_216852686 G A 0.250 0.607 0.500 0.375 0.265 0.000 0.375 0.607 0.750 0.133 0.605 0.529 0.356 0.339 0.507 0.312 0.200 0.231 0.340 0. chrC1_24148281 T C 0.063 0.133 0.333 0.029 0.324 0.000 0.385 0.000 0.000 0.281 0.059 0.147 0.180 0.222 0.209 0.247 0.292 0.324 0.059 0. chrC1_28702055 G T 0.000 0.000 0.000 0.000 0.294 0.000 0.133 0.000 0.000 0.382 0.050 0.100 0.122 0.041 0.000 0.129 0.027 0.029 0.043 0. chrC1_34981315 A G 0.000 0.000 0.000 0.706 0.000 0.067 0.000 0.000 0.000 0.000 0.025 0.000 0.046 0.050 0.099 0.000 0.000 0.012 0.103 0.
£ chrC1_396397 G A 0.050 0.467 0.433 0.000 0.281 0.000 0.357 0.000 0.333 0.235 0.528 0.325 0.392 0.313 0.425 0.139 0.230 0.109 0.030 0. chrC1_44520932 C T 0.250 0.033 0.000 0.000 0.063 0.033 0.033 0.000 0.000 0.000 0.194 0.441 0.134 0.087 0.137 0.003 0.014 0.040 0.015 0. chrC1_52456776 G A 0.750 0.714 0.400 0.281 0.719 0.400 0.192 0.643 0.125 0.643 0.467 0.214 0.342 0.352 0.454 0.747 0.569 0.506 0.529 0. chrC2_106991233 C T 0.438 0.067 0.000 0.147 0.000 0.786 0.100 0.700 0.000 0.206 0.525 0.125 0.261 0.250 0.274 0.279 0.068 0.335 0.578 0. chrC2_147124460 T C 0.444 0.200 0.067 0.647 0.324 0.000 0.321 0.000 0.750 0.147 0.238 0.472 0.516 0.492 0.556 0.416 0.568 0.362 0.186 0. chrC2_150774106 A G 0.000 0.033 0.000 0.607 0.000 0.000 0.367 0.000 0.000 0.029 0.132 0.050 0.072 0.057 0.059 0.032 0.014 0.012 0.014 0. chrC2 156491175 T C 0.786 0.433 0.167 0.765 0.412 0.200 0.464 1.000 0.600 0.545 0.405 0.447 0.381 0.408 0.307 0.672 0.662 0.667 0.313 0. chrC2_187325 C A 0.450 0.038 0.143 0.029 0.000 0.567 0.000 0.429 0.300 0.071 0.105 0.000 0.105 0.195 0.289 0.168 0.216 0.211 0.383 0. chrC2_262401 G A 0.444 0.067 0.133 0.059 0.094 0.333 0.107 0.531 0.571 0.059 0.125 0.306 0.188 0.283 0.277 0.122 0.153 0.280 0.591 0. chrC2_5215469 T C 0.050 0.000 0.400 0.344 0.088 0.800 0.179 0.286 0.417 0.235 0.286 0.395 0.241 0.342 0.250 0.728 0.500 0.313 0.838 0. chrD1_101321498 A G 0.250 0.607 0.000 0.618 0.765 0.100 0.462 0.000 0.643 0.500 0.375 0.368 0.441 0.279 0.281 0.258 0.432 0.134 0.061 0. chrD1_104941557 C T 0.200 0.100 0.000 0.028 0.088 0.000 0.107 0.000 0.000 0.438 0.024 0.105 0.144 0.197 0.147 0.136 0.243 0.052 0.014 0. chrD1_105498119 T C 0.000 0.231 0.033 0.472 0.156 0.000 0.100 0.000 0.000 0.324 0.095 0.100 0.182 0.094 0.180 0.040 0.081 0.177 0.042 0. chrD1_10789012 G A 0.389 0.133 0.333 0.111 0.176 0.267 0.467 1.000 0.750 0.412 0.306 0.400 0.322 0.362 0.230 0.401 0.149 0.149 0.368 0. chrDU 1484008 C T 0.167 0.067 0.000 0.176 0.000 0.133 0.000 0.250 0.071 0.088 0.156 0.025 0.068 0.073 0.044 0.178 0.189 0.247 0.081 0. chrD1_117527468 G A 0.100 0.067 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.125 0.000 0.040 0.01 1 0.004 0.003 0.000 0.000 0.000 0. chrD1_125811329 G A 0.167 0.133 0.233 0.094 0.059 0.633 0.192 0.733 0.500 0.206 0.150 0.200 0.308 0.151 0.206 0.096 0.324 0.169 0.518 0. chrD1_126256993 T C 0.833 0.267 0.333 0.559 0.059 0.667 0.500 0.676 0.250 0.375 0.325 0.056 0.233 0.228 0.188 0.144 0.378 0.221 0.819 0. chrD1_126847301 T C 0.000 0.000 0.000 0.000 0.059 0.179 0.1 15 0.000 0.000 0.147 0.000 0.147 0.100 0.137 0.218 0.010 0.054 0.052 0.043 0. chrD1_15984279 A G 0.222 0.100 0.000 0.794 0.059 0.033 0.417 0.000 0.167 0.235 0.289 0.316 0.245 0.278 0.265 0.050 0.014 0.100 0.368 0.
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Allele Allele
Figure imgf000048_0001
chrD1_16242433 A 0.167 0.333 0.583 0.125 0.118 0.792 0.409 1.000 0.300 0.300 0.235 0.346 0.336 0.256 0.273 0.139 0.143 0.198 0.517 0. chrD1_18390852 G 0.167 0.300 0.233 0.056 0.765 0.067 0.292 0.563 0.000 0.200 0.175 0.105 0.223 0.171 0.111 0.006 0.108 0.080 0.000 0. chrD1_18570323 G 0.300 0.286 0.167 0.361 0.147 0.533 0.500 0.029 0.500 0.324 0.214 0.475 0.401 0.409 0.561 0.243 0.527 0.430 0.379 0. chrD1_66177762 A 0.000 0.300 0.000 0.028 0.294 0.000 0.033 0.000 0.000 0.029 0.048 0.075 0.161 0.112 0.104 0.010 0.097 0.052 0.014 0. chrD2_1020904 G 0.000 0.400 0.167 0.188 0.000 0.033 0.321 0.813 0.571 0.382 0.619 0.605 0.420 0.437 0.689 0.631 0.703 0.667 0.329 0. chrD2_105772916 G 0.600 0.143 0.167 0.969 0.176 0.933 0.267 0.500 0.500 0.250 0.357 0.395 0.192 0.272 0.372 0.284 0.338 0.412 0.426 0. chrD2_1752007 A 0.200 0.133 0.300 0.625 0.088 0.533 0.000 0.000 0.000 0.088 0.167 0.053 0.135 0.056 0.043 0.133 0.041 0.147 0.250 0. chrD2_56777338 T 0.150 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0. chrD2_717969 T 0.643 0.167 0.667 0.906 0.471 0.933 0.200 0.563 0.250 0.781 0.368 0.658 0.402 0.252 0.542 0.256 0.136 0.432 0.719 0. chrD2_74293444 T 0.200 0.200 0.100 0.059 0.059 0.633 0.286 0.000 0.071 0.235 0.250 0.150 0.208 0.151 0.155 0.122 0.189 0.134 0.118 0. chrD2_91989307 A 0.100 0.067 0.133 0.029 0.118 0.200 0.000 0.000 0.000 0.031 0.050 0.000 0.133 0.041 0.065 0.013 0.041 0.029 0.014 0. chrD3_103840114 T 0.150 0.000 0.000 0.000 0.000 0.000 0.000 0.750 0.000 0.000 0.100 0.100 0.022 0.040 0.043 0.039 0.135 0.046 0.000 0. chrD3_122502120 T 0.100 0.143 0.000 0.000 0.000 0.133 0.067 0.118 0.071 0.125 0.275 0.075 0.176 0.236 0.243 0.313 0.392 0.310 0.313 0. chrD3_1810839 G 0.071 0.423 0.500 0.000 0.800 0.000 0.643 0.292 0.167 0.667 0.292 0.750 0.603 0.528 0.427 0.065 0.129 0.211 0.143 0. chrD3_24565823 A 0.250 0.267 0.333 0.000 0.235 0.100 0.033 0.059 0.000 0.176 0.024 0.026 0.151 0.024 0.030 0.003 0.000 0.023 0.028 o. chrD3_24823793 G 0.050 0.000 0.000 0.056 0.000 0.367 0.033 0.133 0.583 0.125 0.025 0.025 0.073 0.184 0.186 0.197 0.541 0.339 0.250 0. chrD3_28838660 C 0.100 0.033 0.067 0.147 0.000 0.200 0.036 0.679 0.500 0.094 0.000 0.000 0.022 0.011 0.009 0.000 0.041 0.100 0.343 0. chrD4_41078218 C 0.700 0.536 0.733 0.231 0.438 0.400 0.654 0.000 0.900 0.038 0.429 0.550 0.458 0.491 0.482 0.493 0.919 0.402 0.212 0. chrD4_42000379 C 0.000 0.033 0.200 0.233 0.000 0.000 0.000 0.000 0.000 0.324 0.167 0.139 0.077 0.134 0.106 0.038 0.014 0.078 0.015 O. chrD4_63622083 A 0.000 0.429 0.500 0.292 0.294 0.000 0.179 0.029 0.333 0.000 0.075 0.139 0.241 0.082 0.065 0.069 0.083 0.135 0.061 O. chrE1_130875919 A 0.000 0.233 0.000 0.000 0.088 0.000 0.067 0.000 0.000 0.250 0.225 0.083 0.271 0.103 0.303 0.013 0.000 0.061 0.061 O. chrE1_131587399 A 0.056 0.269 0.100 0.000 0.382 0.000 0.000 0.000 0.000 0.176 0.083 0.000 0.141 0.047 0.022 0.013 0.000 0.023 0.056 O. chrE1_3912105 T 0.500 0.200 0.233 0.000 0.618 0.367 0.200 0.467 0.214 0.000 0.324 0.450 0.199 0.076 0.097 0.123 0.405 0.092 0.074 0. chrE1_4114158 t 0.200 0.067 0.033 0.382 0.147 0.500 0.367 0.676 0.333 0.147 0.071 0.474 0.438 0.461 0.415 0.507 0.365 0.458 0.439 0. chrE1_48228153 A 0.200 0.067 0.033 0.382 0.147 0.500 0.367 0.676 0.333 0.147 0.071 0.474 0.205 0.196 0.147 0.145 0.176 0.198 0.530 0. chrE1_48700963 T 0.222 0.100 0.067 0.111 0.029 0.000 0.036 0.000 0.000 0.000 0.025 0.050 0.096 0.060 0.048 0.000 0.027 0.034 0.000 O. chrE1_5453028 A 0.000 0.286 0.400 0.278 0.471 0.067 0.462 0.000 1.000 0.647 0.633 0.350 0.522 0.376 0.435 0.211 0.284 0.157 0.029 O. chrE2_22632289 A 0.850 0.500 0.300 0.094 0.353 0.833 0.500 0.031 0.917 0.529 0.200 0.389 0.373 0.389 0.421 0.374 0.608 0.371 0.724 0. chrE2_34027888 A 0.000 0.433 0.167 0.156 0.265 0.000 0.033 0.000 0.000 0.000 0.026 0.025 0.059 0.022 0.089 0.000 0.000 0.076 0.014 O.
Table 2b - Intergenic SNP minor allele frequencies by breed and population.
Major Minor
Allele Allele
Figure imgf000049_0001
chrE2_35914023 C T 0.167 0.000 0.000 0.278 0.059 0.033 0.600 0.1 18 0.083 0.107 0.306 0.333 0.275 0.241 0.152 0.050 0.292 0.194 0.181 0. chrE2_36986631 G T 0.200 0.786 0.533 0.333 0.625 0.200 0.467 0.313 0.143 0.324 0.750 0.526 0.410 0.603 0.618 0.392 0.257 0.471 0.281 0. chrE2_38860686 C T 0.150 0.133 0.133 0.056 0.735 0.000 0.179 0.000 0.500 0.059 0.139 0.000 0.297 0.049 0.039 0.090 0.081 0.059 0.015 0. chrE2_39211557 C T 0.389 0.464 0.542 0.300 0.708 0.464 0.500 0.000 0.833 0.462 0.227 0.333 0.440 0.422 0.495 0.411 0.324 0.402 0.407 0. chrE2_65436639 c T 0.500 0.067 0.233 0.000 0.088 0.400 0.133 0.938 0.071 0.235 0.176 0.325 0.227 0.298 0.283 0.330 0.189 0.310 0.147 0. chrE2_7950477 c A 0.722 0.500 0.467 0.806 0.471 0.667 0.433 0.063 0.400 0.781 0.528 0.368 0.457 0.497 0.417 0.566 0.597 0.579 0.677 O. chrE2_8422942 A G 0.050 0.000 0.133 0.028 0.000 0.033 0.000 0.029 0.000 0.000 0.139 0.184 0.078 0.064 0.066 0.320 0.054 0.017 0.028 0. chrE3_36044809 G A 0.000 0.400 0.536 0.028 0.382 0.067 0.133 0.344 0.286 0.500 0.175 0.200 0.237 0.41 1 0.548 0.530 0.243 0.282 0.191 o. chrE3_55434272 C T 0.250 0.500 0.600 0.471 0.412 0.333 0.583 0.000 0.100 0.633 0.553 0.21 1 0.385 0.383 0.421 0.039 0.324 0.317 0.303 O. chrE3_67006512 C T 0.056 0.067 0.357 0.000 0.235 0.000 0.091 0.000 0.000 0.100 0.265 0.333 0.129 0.123 0.109 0.083 0.045 0.032 0.030 o. chrF1 20309325 G A 0.056 0.067 0.233 0.028 0.000 0.667 0.000 0.029 0.000 0.029 0.071 0.306 0.075 0.081 0.022 0.076 0.097 0.034 0.069 o. chrF1_21799641 C T 0.400 0.300 0.400 0.469 0.147 0.067 0.433 0.281 0.000 0.156 0.071 0.050 0.331 0.079 0.113 0.048 0.108 0.098 0.042 0. chrF1_26100599 A T 0.750 0.400 0.567 0.176 0.353 0.167 0.714 0.286 0.000 0.176 0.417 0.605 0.356 0.194 0.068 0.072 0.189 0.167 0.186 0. chrF1_27124984 C T 0.150 0.033 0.200 0.059 0.029 0.767 0.071 0.577 0.929 0.125 0.094 0.026 0.206 0.253 0.297 0.373 0.292 0.429 0.667 0. chrF1_38051725 A G 0.444 0.286 0.400 0.882 0.382 0.333 0.633 0.250 0.000 0.500 0.675 0.500 0.541 0.644 0.671 0.317 0.122 0.305 0.530 0. chrF1 565223 G A 0.550 0.179 0.733 0.361 0.706 0.750 0.692 0.824 0.417 0.563 0.632 0.600 0.463 0.438 0.425 0.463 0.608 0.536 0.471 o. chrF1_82068276 G T 0.938 0.444 0.143 0.000 0.417 0.700 0.1 15 0.882 0.333 0.269 0.056 0.079 0.187 0.065 0.059 0.007 0.015 0.250 0.379 0. chrF1_82716202 C A 0.000 0.250 0.167 0.853 0.206 0.067 0.107 0.000 0.000 0.324 0.132 0.026 0.288 0.191 0.125 0.339 0.243 0.100 0.100 0. chrF1_91517402 C T 0.350 0.133 0.233 0.029 0.382 0.033 0.107 0.000 0.000 0.235 0.200 0.225 0.214 0.223 0.184 0.176 0.351 0.327 0.044 o. chrF2_26886470 G A 0.444 0.133 0.433 0.344 0.118 0.833 0.143 0.781 0.750 0.235 0.024 0.100 0.104 0.153 0.104 0.459 0.405 0.494 0.591 0. chrF2_38395360 C T 0.643 0.833 0.367 0.235 0.765 0.033 0.269 0.000 0.214 0.156 0.333 0.025 0.349 0.270 0.279 0.334 0.338 0.360 0.029 0. chrF2_46855978 T C 0.125 0.433 0.500 0.433 0.382 0.433 0.433 0.500 0.200 0.219 0.389 0.316 0.332 0.280 0.309 0.229 0.392 0.407 0.444 0. chrF2_68572596 G A 0.688 0.107 0.133 0.156 0.118 0.964 0.107 0.667 0.125 0.176 0.105 0.000 0.211 0.270 0.318 0.302 0.500 0.323 0.717 0. chrF2_74863327 G A 0.650 0.133 0.400 0.194 0.088 0.433 0.200 0.618 0.071 0.206 0.119 0.553 0.181 0.278 0.282 0.171 0.122 0.306 0.338 0. chrF2_78303221 T C 0.000 0.633 0.500 0.194 0.500 0.000 0.769 0.265 0.857 0.469 0.595 0.275 0.478 0.531 0.470 0.743 0.716 0.429 0.273 0. chrF2_79632602 G C 0.000 0.167 0.000 0.063 0.125 0.000 0.000 0.000 0.000 0.059 0.000 0.000 0.025 0.01 1 0.004 0.062 0.000 0.006 0.000 O. chrF2_8427817 A G 0.222 0.464 0.267 0.679 0.412 0.433 0.417 1.000 0.100 0.781 0.556 0.533 0.390 0.408 0.387 0.227 0.257 0.378 0.350 0.
[0091] As appropriate, the genotypes of at least about 3, 5, 10, 15, 20, 25, 30, 40,
50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 145, 148 or more, SNPs from Table 1 are determined. In some embodiments, the expression levels of all listed SNPs of SEQ ID NOs: 1-148 listed in Table 1 are determined.
[0092] In addition to determination of the plurality of SNPs listed in Table 1 , one or more morphological features and/or the genotype of one or more phenotypic markers can be determined. The morphologic and phenotypic markers can relate to hair length, coat color, coat texture, ear, paw and tail morphology, or a known disease marker. For example, the feline may be evaluated for coat color (e.g., chocolate, cinnamon, dilute, orange, white), coat patterning (e.g., agouti, tabby, spotted, ticked, calico, point coloring), coat texture (e.g., straight or rex), coat length (e.g., hairless, short or long), ear morphology (e.g., normal, curled or folded, paw morphology (e.g., normal or polydactyl), and tail morphology (e.g., manx, bobtail, long). Such phenotypic and morphologic features can be evaluated by visual inspection and/or genetic analysis of the feline.
[0093] Some phenotypic markers can be evaluated by genetic analysis, without visual inspection of the feline. In various embodiments, the methods may further comprise determining the genotype of one or more phenotypic markers identified in Table 3, i.e., as SEQ ID NOs: 149-202.
[0094] As appropriate, the genotypes of at least about 3, 5, 10, 15, 20, 25, 30, 40, 50, or more, phenotypic markers, e.g., listed in Table 3, are determined. In some
embodiments, the expression levels of all listed phenotypic marker of SEQ ID NOs: 149-202 are determined.
[0095] Genetic markers for phenotypic traits, especially traits that are breed specific, find use to distinguish genetically related feline populations. For example, Birman or Siamese are homozygous for the G940A TYR mutation. This same mutation would exclude a Havanna Brown from very closely related breeds, e.g., Siamese, Birman and Himalayan. Colorpoints in the chocolate variety, such as Havana Brown, cannot be homozygous for the mutation. A Korat, Russian Blue or Charteux are by definition solid blue; therefore no other colors or patterns are present. Thus, the presence of mutations that would exhibit other patterns and colors would exclude a cat as one of these breeds.
[0096] A genetic marker for long hair, e.g., the A475C FGF5 mutation, can be used as a means for identifying members of the Persian, Maine Coon, Turkish Angora, Turkish Van and Birman breeds, and likewise a means for discrimination as an exclusion maker for breeds such as the Abyssinian, Egyptian Mau, Sokoke and Ocicat. The long hair mutations can also be used to distinguish different breeds that are long haired varietes within the breed family. For example, a Balinese is a longhaired Siamese and a Cymric is a longhaired Manx. Many cat breeds are designated as a breed, such as Oriental Longhair or Oriental Shorthair, just based on the FGF5 mutations. The frequency of the long hair mutations could also be used to support a breed selection. For example, the Norwegian Forest Cat and the Ragdoll have FGF5 mutations that are less common in other breeds.
[0097] Other single gene traits may be used to identify members of certain cat breeds as well. For example, the G715T TYR mutation, which defines Burmese points, is found in the genomes of felines of Burmese and Singapura breeds. The cinnamon mutation, C298T TYRP1, is common to the red Abyssinian. Certain dominant traits can be homozygous or heterozygous, such as the ear curl of American Curls or the bobtail of the Japanese Bobtail. Tonkinese felines are genetically compound heterozygous for the G940A and the G715T TYR mutations and can produce both pointed and sepia cats, and genetically resemble a Siamese or Burmese, respectively. However, breeding restrictions would not allow these Tonkinese variants to be registered as Siamese or Burmese. Additional phenotypic SNPs that find use include the Norwegian Forest Cat color variant amber (Peterschmitt et al. (2009) Animal Genetics, 40:547-552), three additional long-haired mutations (Kehler et al. (2007) Journal of Heredity, 98:555-566), and the mutations responsible for hairless of Sphynx and rexing of the Devon Rex (Gandolfi et al., Mamm Genome. (2010) (9-10):509-15). A mutation in KIT (c.1035_1036delinsCA) for Birman glove white spotting should be restricted to the Birman breed. Phenotypic genetic markers, as well as disease mutations, find use to further delineate cat breeds.
[0098] Accordingly, morphological and/or phenotypic markers find use to distinguish between genetically related feline breeds, e.g., (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese; (iv) Singapura and Burmese; (v) Birman and Korat, and (vi) Siamese and Havana Brown. For example, determination of whether the feline has the phenotype for long hair can be used to distinguish between Persian and Exotic Shorthair; determination of whether the feline has curled ear morphology can be used to distinguish between British SH and Scottish Fold; determination of fur color and/or pattern can be used to distinguish between Australian Mist and Burmese; between Singapura and Burmese; between Birman and Korat; or between Siamese and Havana Brown. Whereas a Burmese will lack barring and/or spotting, a Singapura possesses the dominant ticked tabby gene, Ta; and an Australian Mist will have spotting and barring. Whereas a Birman and a Siamese will have the mutation for Siamese points (i.e, homozygous for the G940A TYR mutation), a Korat and a Havana Brown will not.
[0099] The use of phenotypic markers to further refine the assignment of a test feline to a breed or ancestral population is demonstrated in Tables 4 and 5.
Table 3 - Phenotypic Markers useful for breed identification test
SEQ ID NO: SNP ID Sequence
149 Phen CMAH G139A AATTTCTTG AG AAACAAG AAGACC RG CAAAGATTTCATTCTGTACAAG AG C
AAG AATYGY[G/A]TG AG GG CGTG CAAG AACGTGTG CAAG CATCAAG GAG K CCTGTTCRTAAAAGACATCGAAG
150 Phen_ASIP_del CCACCCTGCTGGTCTGCCTGTGCCTCCTCACTGCCTACAGTCACCTGGC
ACCTGAG GAAAAACCCAG AG ATG ACAG GAACCTG AG GAG CAACTCCT[CA /-]TGAACATGTTGGATCTCTCTTCTGTCTCTATTGTAGCGCTGAACAAGAA ATCCAAAAAGATCAG CAG AAAAG AG G CG GAAAAG AAGAG ATCTTCCAAGA AAAAGGCTTCG
151 Phen_MLPH_T83del GGCAGAGATGGGGAAAAAACTGGATCTTTCCAAGCTCACGGACGACGAG
GCCAAGCACATCTGGGAAGTGGTTCAGCGGGACTTTGATC[T/-]AGAAGGA
AAGAAGAGGAAAGGCTGGGGTGAGTGTATGAGGCCGAGCCCGTCCCTC
CGGTGTCCCCTGGAAGGGGGGGCCTCCCCGGGACGCTGGGGGTGAGC
A
152 Phen_MC1 R_G250A CCTGGGGCTGGTGAGCGTGGTGGAGAACGTGCTGGTGGTGGCCGCCAT
TGCCAAGAACCGCAACCTGCACTCGCCCATGTATTACTTCATCTGTTGCC TGGCCGTGTCC[G/A]ACCTGCTGGTGAGCGTGAGCAGTGTGCTGGAGAC GGCCGTCATGCTGCTGCTGGAGGCAGGCGCCCTGGCCGGCCGGGCCG CCGTGGTGCAGCGGCTGGA
153 Phen TYRP1 C298T CCGCATGATGGCAGAGATGATCGGGAGGCTTGGCCCACGAGGTTCTTCA
ACAG GACATG C[T/C]G ATGCAATG G CAATTTCTCAG G ACACAACTGTGG G ACTTGCCGTCCTGGATGGAAAGGAG
154 Phen TYRP1 5IVS6 CCTTCACAATTTGGCTCATCTATTCCTGAATGGAACAGGGGGACAAACCC
ATTTATCTCCAAACGATCCTATTTTTGTCCTCCTGCACACTTTCACTGACG CAGTCTTTGATGAATGGCTGAGGAGATATAATGCTGGTGA[G/A]ACATTCT CCTATG CTTTTTTG CAG GCTCAG CAAG
155 Phen_TYR_del975C TTAGCCGATTGGAGGAGTACAATAGCCGTCAGGCTTTATGTGATGGAACT
CCAGAGGGACCATTACTGCGCAATCCCGGAAACCATGACAAAGCCAGGA CCCCAAGGCT[C/-]CCTCCTCTGCTGATGTGGAATTTTGCCTAAGTCTGAC ACAATATGAATCGGGTTCCATGGATAAAGCTGCA
156 Phen_TYR_G715T TTCCTGCCTTGGCACAGACTCTTCTTGTTGCTGTGGGAACAAGAAATCCA
GAAGCTGACC[T/G]GGGATGAGAACTTCACTATTCCATATTGGGATTGGC
GAGATGCTAAAAGCTGTGA
157 Phen TYR G940A TACAATAGCCGTCAGGCTTTATGTGATGGAACTCCAGAGGGACCATTACT
GCGCAATCCC[A/G]GAAACCATGACAAAGCCAGGACCCCAAGGCTCCCCT CCTCTGCT Table 3 - Phenotypic Markers useful for breed identification test
SEQ ID NO: SNP ID Sequence
158 Phen_KIT_G1035C_BI TTTCATTAACATCTTCCCTATGATGAATACCACAATATTCGTGAATGATGG
CGAGAATGTGGATCTGATTGTCGAATATGAGGCATATCCCAAGCCTGA[G/
C]MACCAACGGTGGGTCTATATGAACAGAACCCTCACTGATAAATGGGAA
GATTATCCCAAGTCTGACAACGAAAGTAATATCAGGTAAGAAAAAAGCCTT
ACGCTGAGGATCAGATGTTTTCC
159 Phen_FGF5_475 TGCTGAAAATATTATTACTATTTACAAGTTTTTCTTCTTTCCCCCCACCAGG
CCAAATTT[A/C]CCGATGACTGCAAGTTCAGGGAGCGATTCCAAGAAAACA GCTATAATACCTATGCCTCAG
160 Phen_FGF5_474 TGCTGAAAATATTATTACTATTTACAAGTTTTTCTTCTTTCCCCCCACCAGG
CCAAATT[T/-]ACCGATGACTGCAAGTTCAGGGAGCGATTCCAAGAAAACA GCTATAATACCTATGCCTCAG
161 phen_FGF5_406 ATTTCTGTCATCCTAGGTATTTTGGAAATATTTGCTGTGTCTCAGGGGATT
GTAGGAATA[C/T]GAGGAGTTTTCAGCAACAAATTTTTAGCGATGTCAAAA AAAGGAAAACTCCATGCAAGTGTAAGTAGAACCACTTTATGTT
162 Phen_FGF5_356 GTGGAGCCCCTCGGGGCGCCGGACCGGCAGCCTCTACTGCAGAGTGGG
CATCGGTTTCCATCTGCAGATCTACCCGGATTGGCAAAGTCAATGGCTCC
CATGAAGCCAATA[T/-]GTTAAGTAAGTTGCTCGCCCTCCTGGCAAAGCGC
GTCCTAAGCGGGCGATGGGGGGRTTCGGGAGGGACAGAGGCTATTCCC
TGGCCCACAGGCGCACCTTCCGGAGCCCTGGCTCCTGGGACTCAGCTGT
CCCTCGGAACC
163 Phen_GBL1_G1457C CCCAGGGAGTCCTGGAGCGAAGTTACGTGATCACTCTGAACATAACAGG SIA_KOR GCAAGCCGGAGCCACTCTGGACCTTCTGGTGGAGAACATGGGGC[G/C]T
GTG AACTATG G CAG ATACATCAATG ATTTCAAG GTAGG ACCAGCCTCG CT GTCGAGGTCGATAGGACTGTGTCTGTGCCACCCGAGGA
164 Phen_HEXB_Dellntr_B ACCATGAACTGACCAAGGGACCAGTAATTGCCTCTGTCAGACTACTACTG UR CATTTTGCCTATTGCCTCTGCAACTACTTCATTTACAGCCATTCAATGATTT
[TAATGTAGGTTCTCA/-]AGAACAGAAAAAACTTGTCATTGGTGGAGAAGCT
TGTCTGTGGGGAGAATTTGTGGATGCAACTAACCTTACTCCAAGATTATG
GTATGGAAT
Phen_HEXB_del39C GGCTGGGGCTGGCGGCGCTGCTGGCGCTGCTGGCGGCCGTGGCCCCG KOR CGCTCCTCCGCCGCCGCGGAGCCGCCCTGTGGCCTATGCCGCTCTCGG
TGAAGACGTCTCCGCGCCTGCTGCA[C/-]CTCTCCCGCGACAACTTCTCCA
TCGGCTACGGCCCCTCGTCCACCGCCGGCCCCACCTGCTCCCTCCTGCA
GGAAGCTTTTCGGCGATATCACGAATACATTTTTGGTTTCGACAAGAGG
166 Phen GBE1 Ins NFC TTAAGAATATTCATTCTAGGGGCGCCTGGGTGGCGCAGTCGGTTAAGCG
TCCGACTTCAGCCAGGTCACGATCTCGCGGTCTGTGAGTTCGAGCCCCG
CGTCGGGCTCTGGGCTGATG[C/-]CCAGAGCCCGACGACATGGGTCAAAC
TCACCGACCGCGAGATCGTGTACCTGAGCTGAAGTCGGACGCTTCACCG
TACTGAGCCACCCAGGC
Phen_KRT71_G/Aintro GCCAATAAGGAGGAGCTCCAGGCCAAGGTGGACTCCATGGATCAGGAGA 4_SPX TCAAGTTTTTCAAGTGCCTCTATGAAGCC[G/A]TAAGTCTGTCTCTCCACC
CACCCCTCTGAGGGCAGCCAGCGGGTAAAACTCTGTTCTGG
Phen_MYBPC_G93C GCCTTCAGCAAGAAGCCAAGGTCAGTGGAAGTGGCAGCCAGCAGCTCTG MCC CTGTGTTCGAG[C/G]CCGAGACAGAGCGGTCAGGAGTAAAGGTGCGCTG
GCAGCGGGGGGGCAGTGACATCAGCG
Phen_MYBPC_C2460 GTCCCCCCTTCATCAGGCTACATCCTGGAGCGCAAGAAGAAGAAGAGCT T_RAG TCCGGTGGATG[T/C]GGCTGAACTTTGACCTGCTGCAGGAGCTGAGCCAC
GAGGCACGGCGCATGATTGAGGGCG Table 3 - Phenotypic Markers useful for breed identification test
SEQ ID NO: SNP ID Sequence
170 phen_MPO_ALC GTGCAGTTGGGGGATCGCAGAAGAGGGCTGGGCACATGCAGCTCCTGG
TGCCAAGGTCAC[T/C]CCAGTGGGCAGGTCTTCACCAGGGAATCAAGGTC TCAAGGTATAATGCCATTCAGACTTG
171 Phen_PLAU_AG_ALC TGTATCTAAGGAAGAATGTGAGGATGAGAGATATTAGAAAGAGGAGGAAA
TTCAGACAGG[T/C]GTTTTAGAGATCCTGTCAGGCCTTGCATGATTTCAGA CCTGG
172 Phen_FCAT_ALC AAAAGCTGATGTACTTGTGCCCAGGGAAGATGTCAATATTTACCATTAACT
GTTGTGAAA[A/G]ATTCAACCAATGTACTCAGTTGAAGTTCTTTTCATTTTA TTG G ATTAAAAAAATCACTAT
173 Phen_PKLR_13delE6_ CGCCCACCGGTGCCTGTTCCGTGCACGGCCCAGGCCCCAAGGTGGACA Aby GGCAATAGGACACGGGTTCCTGATTTCCTGGGGGCCCACGCCCCGTGCC
CCCGCTCCAC[G/A]ACTCTGCCCCCGGCTYGCCCCTGACCTGCGCTGGC TCTTCCCATGCCTGCAGGCCCGGAGGGGCTGGAGACCCACGTGGAGAA CGGCGGCGTCCTGGGC
174 Phen_PKD1_C10063A CTCCCTCTGGGACCGGCCTCCTCGGAGCCGCTTCACCCGCGTCCAGCG _PER GGCCACCTGTTG[A/C]GTCCTCCTCGTCTGCCTCTTCCTGGGCGCCAATG
CTGTGTGGTACGGGGTCGTGGGAGAC
175 Phen_SHH_A479G_H CCAGTGGCTAATTTGTCTCAGGCCTCCGTCTTAAAGAGACAC[A/G]GAAAT w GAGTAGGAAGTCCAGCGTGGTCTCAGAGAGCT
176 Phen_CEP290_PRA_ AACAGAGAGGGAGCAAAAAGCTAAGAAATACACTGAAGACCTTGAGCAAC Aby AAGCAAGTAA[T/G]TTTTCTTTATGAGAAAATAATGCATTTCATCTCAAGCC
ACTCCTTGGCATTGTTTTAA
177 Phen_CRX_546_Aby TCCCCCACCTCGGCCGTGGCCACGGTGTCCATCTGGAGTCCCGCCTCG
GAGTCCCCTCTGCCCGAGGCCCAGCGGGCGGGGCTGGTGGCGGC[C/-]G GGCCCCCTCTGACCTCCGCGCCCTACGCCATGACCTACACCCCCGCCTC TGCTTTCTGCTCTTCCCCCTCGGCCTACGGGTCTCCGAGCTCCTATTTCA GTGGCC
178 Phen_CMAH_del AGTAGTGAACCGCGTGCATATGCATCCTCCGTCTCATACTTTGTGGGAGC
A[AACGAGCAACCGAAGCTG/-]AACGAGCAACCACCGTCCTTTCAGAATTC CCAGGGAGAGGCAGCTGCGGACCATGGGCAGGCAAGTGACAGGGGCAT TGGGTCTGGAGGAACCCGAGACCAACACTGAGCA
179 Phen_HEXB_C667T_ TCTCTGTCTCATGTTTATACACCAAACGATGTCCATACGGTGATTGAATAT DSH GCCAGATTA[T/C]GAGGGATTCGAGTCATACCAGAATTTGATAGCCCTGGA
CATACACAGTCTTGGGGAAAAG
180 Phen_GM2A_Del_DS TCACTGCCGGAGAGTGATTTCACCCTGCCCCAGCTGGAGGTGCCCGGCT H GGCTTAGCTCTGGGCACTACCGCATCAAGAGGT[C/T]CCTCAGCAGCGGT
GGGGAGCGTCTGGGCTGTGTCAAGATCTCTGCCTCTCTGAAGGGCAAAT AATGTGGCACCAGCCACA
181 Phen_GRHPR_DSH ACCTGGAGAGGATGATCTTCTCCCCCTGGGGGTTCTGGGTCTGTGAGTT
TGCAGTGAGCCCTCATCTTTGCCCAAGGTGGGGTCCTCTTACCCACCCCT TCTCTCCTCACA[G/A]CGGTGGCTGGACCTCATGGAAGCCCCTGTGGATG TGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGGCTGGGGC GC
182 Phen_LPL_G1234A_D GAG CG ATTCATACTTCAG CTGGTCAG ACTG GTG GAG CAG CCCTG G GTTT SH ACTATTGAGAAGATCAGAGTAAAAGCA[G/A]GAGAGACTCAAAAAAAGGTA
ATCTTCTGTTCCAG GG AG AAAGTATCTCATCTG CAG AAAG GAAAG G CATC TGTGGTATTTGTGAAATGCCATG Table 3 - Phenotypic Markers useful for breed identification test
SEQ ID NO: SNP ID Sequence
183 Phen_LAMAN_del_PE ACGGTCAGGAACTGCTTTTCCCAGCCTCGGTGCCTGCCCTGGGCTTCAG R CATCTACTCAGTAAGCCAGGTGCCTG[GCCA/-]KCGCCCCCACGCCCACA
AACCCCAGCCCAGATCCCAGCGGCCCTGGTCCCGTGTCTTGGCCATCCA AAATGAGCACATCCGGGC
184 Phen_IDUA_del_DSH GGACATCCCGACCCCCTGGACCCCCGCAGGTCATTGCGCAGCACCAGAA
CCTGCTGGTGGCCAACACCAGCTCCCCCGTGCGCTACGCGCTCCTGAGC
AAC[GAC/-]ACGCCTTCCTGAGCTACCACCCGCACCCCTTCACGCAGCGC
ACGCTCACGGCGCGCTTCCAGGTCAACAACACCCGCCCGCCGCACGTG
CAGCTGCTGC
Phen_ARSB_G1558A CTCCAGTTCTACCACAAACATTCAGTGCCTGTGCATTTCCCGGCACAG[A/ SIA G]ACCCCCGCTGTGACCCCAAGGGCACTGGGGCCTGGGGCCCTTGGGTA
TAG G AC
Phen_ARSB_T1427C CGTCTCCATACAACGATTCTGCGATACCCTCATCAGACCCACCGACCAAG Sia ACCCTCTGGC[T/C]CTTTGATATTGATCAGGACCCAGAAGAAAGACATGAC
CTGTCAAGAGACTATCCCCATAT
Phen_GUSB_A1052G GATTCGCACGGTGGCTGTCACAGAGCACCAGTTCCTCATCAATGGGACC DSH TTTCTATTTCCACGGGGTCAACAAGCAC[G/A]AGGATGCAGATATCCGAG
GGAAGGGCTTTGACTGGCCACTGCTGGTGAAGGACTTCAATTTGCTTCG CTGGCTCGGGGCCAACGCCTCCGCACCAGTCACTACCCCTA
Phen_MYBPC_A74T CTTCAGCAAGAAGCCAAGGTCAGTGGAAGTGGCAGCCAGCAGCTCTGCT Poly GTGTTCGAGSCCGAGACAGAGCGGTCAGGAGTAAAGGTGCGCTGGCAG
CGGGGGGGCAGTGACATCAGCGCCAGTGACAAGTATGGCCTAGCARCC
GAGGGCACGAGGCACACTCTGACAGTGCGGGACGTGGGCCCC[G/A]CCG
ACCAGGGACCCTACGCAGTCATCGCT
Phen_NPC1_G2864C GCTTTGCTCCCTCTTCCTGGATCGACGATTACTTTGATTGGGTCAAGCCT PER CAGTCTTCTT[C/G]CTGTAGAGTCTACAACAGCACCGATCGGTTCTGCAAT
GCTTCAGGTACTTTCATCTCCTT
Phen_SHH_G257C_U TAATTAGACTGACCAGGTGGCAGCAAAGAGCCGGGTGCC[C/G]GTGCTG K1 GGAAGGCCTATAAAGCTGAGCGCTGTGACAGCACA
Phen_SHH_A481T_U CCAGTGGCTAATTTGTCTCAGGCCTCCGTCTTAAAGAGAC[A/T]CAGAAAT K2 GAGTAGGAAGTCCAGCGTGGTCTCAGAGAGCT
Phen_HMBS_del842_ GTCCCCGTGCACGTCAAGTTGTCCACAAGAGCCCAGGTTTCTAACCAGTT SIA CTCTCAGAATATGCTGAGATAACCATTTTCTTTCCCAGCTGTACCTGACAG GAG [G AG/-]TCTG G AGTCTAG ACG G CTCAGATAGCATG CAAG AGACCATG CAGGCCACCATTTGTGTCACTGCCCAGGTGCCAAAGCTGGAGGGTGAGG GAGAGGGTGAG
193 Phen- TTAGTACAGTGCTGGGCTCAGTAGGGGCTCGTTAAACGCCAATAGATGA
HMBS_189TT_SIA GCACGTGACTGATTCTCTCCTCAGTTGCTATGTCCACCACAGGGGACAAG
ATT[-/T]CTTGATACTGCGCTCTCTAAGGTAACGTGTTCCCCCCAATCCCTT
TCCCTCCTTTCTCTTTCCTTCCCCCAAAAGATTCACTCTGAGGCTTTTTCT
TGACC
194 Phen CYP21 B1 GGAGGCACCCGCCTGGGTTTCTCAGTGCCCTGACAGCGCCCCCTCGCG
CCCAGGGATAGCCGCCGTGCTCCTGGGTTCACGCCTGGGCTGCCTGGA GGCCGAAGTGCCTCCAGACACAGAGACCTTCATCCGCGCGGTGGGATC GGTATTTGTGTCCACGCTGCTGACCATGGCGATGCCTAGCTGGCTTCAC
C[G/-]CCTCGTGCCCGGACCCTGGGGCCGCCTCTGCCGAGACTGGG Table 3 - Phenotypic Markers useful for breed identification test
SEQ ID NO: SNP ID Sequence
195 Phen_TAS1 R2_CAT CCCTCCTGGGCCACCAGATCTTTTTTGACCAGCGAGGGGACCTACTCAT
GCGCCTGGAGATCATCCAGGGACGGTGGGACCTGAGCCAGAAC[T/-]TTT CTGGAGCGTCGCCTCCTACTGCCCGGTGCTACGACGGCTGAGGGCCAT CCGTGACGTCTCCTGGCACACGGCCAACAACAC
196 Phen_TAS1 R2_G8224 TTGCAGACGAGTTTGGCTGCCGGCCCTGCCCGAGTTGCGGGTGGTCCC A_CAT GGAGGAACGACGCTTCGTGCTTCAAGCGGCGGCTGGCCTCCCTTGAATG
[G/A]CGCGAGGCACCCGCCGTCGCTGTGGCCGTGCTGTCCATCCTGGGC
TCCCTCTGCACCCTGGCCATCCTGGTGATCTTCTGGAGGCACCGCCACG
CGCC
197 Phen_CYP27B1_Rob GGAGGCACCCGCCTGGGTTTCTCAGTGCCCTGACAGCGCCCCCTCGCG
CCCAGGGATAGCCGCCGTGCTCCTGGGTTCACGCCTGGGCTGCCTGGA
GGCC[G/T]AAGTGCCTCCAGACACAGAGACCTTCATCCGCGCGGTGGGAT
CGGTATTTGTGTCCACGCTGCTGACCATGGCGATGCCTAGCTGGCTTCA
CC
198 Phen ZFX GGTTTTCGTCACCCGTCAGAGCTCAAGAAGCACATGCGAATCCATACTGG
GGAGAAGCCGTACCAGTGCCAGTACTGCGA[G/A]TATAGGTCTGCAGACT CTTCTAACTTGAAAACGCATGTAAAAACTAAGCATAGTAAAGAGATGCCAT TCAAGTGTGACATCTGTCTTCTGACT
199 KRT71-Del Drex GGTGGGCATCCCTGCCNGGGAATCAGCAAGCNCTAGTGNGATTTGGATT
TGGATGACTCGAATTACCCCTTCCAGTTTTTGAACTTCTCCAACTCCCTGT
[TTAGGCTTCCAACCTGGAGACGGCCATCGCCGATGCCGAGCAGCGGGG
CGACAGTGCCCTGAAGGATGCCCGGGCCAAGCT/-][-/AGTTGGAG]GGAC
GAGCTGGA[-/T]GTCCGCCCTGCACCAGGCCAAGGAGGAGCTGGCCCGG
ATGCTGCGGGAGTACCAGGAGCTCATGAGCCTGAAGCTGGCCCTGGACA
TGGAGATCGCCACCTACC
200 P2RY5 CRex ACACTTTGTATGGCCGCATGTTTAGTATGGTATTTGTGCTTGGGTTAATAT
CTAACTGTGTTGCCATATACATTTTCATCTGCACCCTCAAAGTGCGAAATG
AAACTACAACATACATGATTAACTTGGCAATGTCAGACTTGCTTTTCGTTT
TTACTTTACCCTTCAGGATTTTTTACTTTGCAACCCAGAATTGGCC[GTTT/-
]GGAGATCAACTCTGTAAAATTTCAGTGATGCTATTCTATACCAACATGTAT
GGAAGCATTCTGTTCTTAACCTGTATTAGTGTCGATCGGTTTCTGGCAAT
201 WNK4 Burm HKL TGCCCCTCTGCTTCCCCCCTTCCGTCCACCACAGCAGCCCCTCTCCTCTC
TCTGGCTAGTGCCTTCTCACTGGCTGTGATGACTGTGGCCCAGTCCCTG
CTGTCTCCCTCACCTGGGCTCCTGTCCCAGTCTCCTCCAGCCCCTCCTG
CTCCCCTCCCTAGCTTGCCCCTGCCCCCTCCCCCTGCTCCTTGTGGC[C/T
]AGGATAGGCCTTCACCCCCAACAGCTGAGACCGAGAGTGAGGTGAGTA
GGAAACCAAGAGGGATGGTTAGGGGAGCTCCACTCTGGATCATTTCCCT
TCTCATGGACCCACACTTTGCAGGTCCCGCCAAATCCTGCTCGGCCACTC
202 CART1 del Burm CTCCCGTGAAGGGGATGCCAGAAAAGGGAGAACTAGATGAACTTGGGGA
TAAATGTG ACAG CAACGTATCCAG CAGCAAGAAG CG GAG ACACAG AACC ACCTTCACCAG CCTG CAG CTCG AG GAGCTG GAG AAG GTCTTTCAG AAAA CCCATTACCCGGATGTATACGTCAGAGAACAGCTTG[CTCTCAGGACTG/-] AGCTCACGGAGGCCAGAGTCCAGGTAGGAGCCAAATGAAGGACGTGGG TGTGCGTGTTGGGGGCCGGTGTGTGGAGATACTGTTAGAATAATTCAGT GGTTGCATTTTGCCAAAAGGAAGAAACTGATCCTCTCACTAAAGACTAGA ACC Table 4
No. Defining Variant Phenotypic SNPs / genotypes (Inclusive (I) / Exclusive (E))
Registry Breed Category Family for family Agouti Brown Color Dilute Extension Glove Hairless Inhibitor Orange Spotting White Long Rex Rex 2
4 Abyssinian 1 Abyssinian aa - E bb = E CC = I E E E E E E E L- = l E E
2 American Shorthair 1 cbcb = E E E E L- = l E E
4 Birman 1 aa = I cscs = I E I E E II - I E E
4 British Shorthair 1 Persian C- = l E E E E E
4 Burmese 1 Burmese aa = I cbcb=l E E E E E E E
3 Chart re ux 1 aa = I BB, Bb = I C- = l dd = I E E E E E E E
4 Cornish Rex* 1 Rex cbcb = E E E E I E
4 Devon Rex 1 cbcb = E E E E E rere = I
4 Egyptian Mau 1 C- = l E E E E E E E
3 Japanese Bobtail 1 cbcb = E E E E E E
4 Korat 1 aa = I BB, Bb = I C- = l dd = I E E E E E E L- = E E E
•J\
4 Maine Coon 1 C- = l E E E II - I E E
4 Manx? 1 C- = l E E E E E
4 Norwegian Forest 1 C- = l I E E E E
4 Persian 1 Persian cbcb = E E E E E E
4 Russian Blue 1 aa = I BB, Bb = I cbcb = E dd = I E E E E E E E
4 Siamese 1 Siamese aa = I blbl = E cscs = I E E E E E E
3 Turkish Angora 1 cbcb = E E E E E E
4 Turkish Van 1 cbcb = E E E E E E
X Asian 2 Burmese E E E E E
4 Balinese 2 Siamese Long/Brown/Dilute aa = I bibi = E cscs = I E E E E E E
3 Bombay 2 Burmese Color aa = I B- = l C- = l dd - E E E E E E E E
2 Colorpoint 2 Siamese Agouti cscs = I E E E E E
2 Cymric^ 2 Manx Long cbcb = E E E E E E
4 Exotic Shorthair 2 Persian Long cbcb = E E E E E E
3 Havana Brown 2 Siamese Color aa = I bb = I C- = l dd = E E E E E E E E
X Himalayan 2 Persian Color cscs = I E E E E E
4 Oriental 2 Siamese Color cscs = E E E E E E
Table 4
•J\
Disease info: F disease SNP is frequent in the breed and may be breed specific
V the SNP variant has different frequencies in different breeds,
Categories: founder breed (N = 19, genetically defined by SNPs)
2 = Breed variants (N = 16), distinguish with other phenotypic SNPs or DNA variants
3 = Breeds may be like random breds (N = 9), but if found mutation, could distinguish.
4 = Hybrid breed (N = 2), need wildcat diagnostics, Y STRs
5 = Ftendom bred (N = 4), regional, 3 completed, Euro SH underway, but define as breeds in breed only comparison
6 = concoction breeds (N = 3), will show mixture, defining variants will be of assistance
7 = Foreign Burmese may have distinct gene pool from USA Burmese, separate breed
§Variant found, unpublished
•Could share fur type variant
Table 5
Structural Trait Disease Traits
Aby Aby
Defining Variant Blood Korat Korat Burmese NFC MCC Ragdoll PRA PRA Persian Aby
Ear Poly- Type
Breed Family for family Dwarf Curl Fold Bobtail Tailless dactyla B GM1 GM2 GM2 GSD HCM HCM CEP290 CRX PKD PKLR
Abyssinian Abyssinian E E E E E E V F F F American Shorthair E E E E E E V
Birman E E E E E E V
British Shorthair Persian E E E E E E V
Burmese Burmese E E E E E E V
Chartreux E E E E E E V
Cornish Rex* Rex E E E E E E V
Devon Rex E E E E E E V
Egyptian Mau E E E E E E V
Japanese Bobtail E E E 1 E E V
Korat E E E E E E V
Maine Coon E E E E E F V
Manx§ E E E E 1 E V
Norwegian Forest E E E E E E V
Persian Persian E E E E E E V
Russian Blue E E E E E E V
Siamese Siamese E E E E E E V
Turkish Angora E E E E E E V
Turkish Van E E E E E E V
Asian Burmese E E E E E E V
Balinese Siamese Long/Brown/Dilute E E E E E E V
Bombay Burmese Color E E E E E E V
Colorpoint Siamese Agouti E E E E E E V
Cymric§ Manx Long E E E E 1 E V
Exotic Shorthair Persian Long E E E E E E V
Table 5
Structural Trait Disease Traits
Aby Aby
Defining Variant Blood Korat Korat Burmese NFC MCC Ragdoll PRA PRA Persian Aby
Ear Type
Breed Cat. Family for family Dwarf Curl Fold Bobtail Tailless B GM1 GM2 GM2 GSD HCM HCM CEP290 CRX PKD PKLR
Havana Brown 2 Siamese Color E E E E E E V
Himalayan 2 Persian Color E E E E E E V
Oriental 2 Siamese Color E E E E E E V
Ragamuffin 2 Ragdoll Not pointed E E E E E E V
Singapura 2 Burmese Agouti E E E E E E V
Somali 2 Abysinnian Long E E E E E E V
Sphynx 2 Devon Rex Hairless/Rex E E E E E E V
Tiffanie 2 Burmilla Long/Silver E E E E E E V
Scottish Fold 3 Persian Fold E E I E E E V
European Shorthair 5 E E E E E E V
Ragdoll 5 Ragdoll E E E E E E V
Siberian 5 E E E E E E V
Sokoke 5 E E E E E E V
Australian Mist 6 Burmese E E E E E E V
Burmese Non-USA 7 E E E E E E V
Tonkinese 2/6 Burmese/Siamese Color E E E E E E V
Bengal 1/4/6 Aby/Mau Ticked E E E E E E V
Snowshoe ? Birman? bicolor, sh E E E E E E V
Ocicat 1 (6) Aby/Siamese Color/Ticked/Tabby E E E E E E V
[0100] In addition to determination of the plurality of SNPs listed in Table 1 , the genotype of one or more microsatellite markers and/or short tandem repeats (STRs) can be determined. For example, the genotype of one or more feline STRs selected from the group consisting of selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698. The identity and location of feline microsatellites and STRs have been characterized and mapped, as described, e.g., in Menotti-Raymond, et al., Genomics (1999) 57(l):9-23; Menotti-
Raymond, et al., Journal of Heredity (2003) 94(1):95— 106; and Menotti-Raymond, et al., Genomics (2009) 93(4): 305-313.
[0101] As appropriate, the genotypes of at least about 3, 5, 10, 15, 20, 25, 30, 35,
38, or more, feline STRs are determined. In some embodiments, the expression levels of all STRs selected from FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698 are determined.
5. Methods of Detecting Biomarkers
[0102] In some embodiments, methods comprise obtaining the identity of one or both alleles in a test feline genome for each marker of a set of markers. The genetic markers described herein, including the SNPs, STRs and phenotypic markers, can be detected using any methods known in art, including without limitation amplification, sequencing and hybridization techniques. Detection techniques for evaluating nucleic acids for the presence of a single base change involve procedures well known in the field of molecular genetics. Methods for amplifying nucleic acids find use in carrying out the present methods. Ample guidance for performing the methods is provided in the art.
Exemplary references include manuals such as PCR Technology: PRINCIPLES AND APPLICATIONS FOR DNA AMPLIFICATION (ed. H. A. Erlich, Freeman Press, NY, N.Y., 1992); PCR PROTOCOLS: A GUIDE TO METHODS AND APPLICATIONS (eds. Innis, et al, Academic Press, San Diego, Calif, 1990); CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Ausubel, 1990-2008, including supplemental updates;
Sambrook & Russell, Molecular Cloning, A Laboratory Manual (3rd Ed, 2001).
[0103] According to one aspect of the present invention, there is provided a method for assigning a feline to one or more breeds and/or populations of origin based on the genotypes of a set of gene polymorphisms. The method comprises the steps of first isolating a genomic DNA sample from a feline, and then detecting, e.g., amplifying a region genomic DNA including the one or more of the genetic markers using an oligonucleotide pair to form nucleic acid amplification products of the one or more gene polymorphism sequences. Amplification can be by any of a number of methods known to those skilled in the art including PCR, and the invention is intended to encompass any suitable methods of DNA amplification. A number of DNA amplification techniques are suitable for use with the present invention. Conveniently, such amplification techniques include methods such as polymerase chain reaction (PCR), strand displacement amplification (SDA), nucleic acid sequence based amplification (NASBA), rolling circle amplification, T7 polymerase mediated amplification, T3 polymerase mediated amplification, SP6 polymerase mediated amplification, and GoldenGate amplification assays. The precise method of DNA amplification is not intended to be limiting, and other methods not listed here will be apparent to those skilled in the art and their use is within the scope of the invention.
[0104] In some embodiments, the polymerase chain reaction (PCR) process is used (see, e.g., U.S. Pat. Nos. 4,683,195 and 4,683,202. PCR involves the use of a
thermostable DNA polymerase, known sequences as primers, and heating cycles, which separate the replicating deoxyribonucleic acid (DNA), strands and exponentially amplify a gene of interest. Any type of PCR, including quantitative PCR, RT-PCR, hot start PCR, LA-PCR, multiplex PCR, touchdown PCR, finds use. In some embodiments, real-time PCR is used.
[0105] The amplification products are then analyzed in order to detect the presence or absence of at least one polymorphism in the feline genome that is associated with the desired genotypes and/or phenotypes, as discussed herein. By practicing the methods of the present invention and analyzing the amplification products it is possible to determine the genotype of individual animals with respect to the polymorphism.
[0106] In some embodiments, the genetic markers may be detected by restriction fragment length polymorphism (RFLP) analysis of a PCR amplicon produced by amplification of genomic DNA with the oligonucleotide pair. In order to simplify detection of the amplification products and the restriction fragments, those of skill will appreciate that the amplified DNA will further comprise labeled moieties to permit detection of relatively small amounts of product. A variety of moieties are well known to those skilled in the art and include such labeling tags as fluorescent, bioluminescent, chemiluminescent, and radioactive or colorigenic moieties.
[0107] A variety of methods of detecting the presence and restriction digestion properties of amplification products are also suitable for use with the present invention. These can include methods such as gel electrophoresis, mass spectroscopy or the like. The present invention is also adapted to the use of single stranded DNA detection techniques such as fluorescence resonance energy transfer (FRET). For FRET analysis, hybridization anchor and detection probes may be used to hybridize to the amplification products. The probes sequences are selected such that in the presence of the SNP, for example, the resulting hybridization complex is more stable than if there is a G or C residue at a particular nucleotide position. By adjusting the hybridization conditions, it is therefore possible to distinguish between animals with the SNP and those without. A variety of parameters well known to those skilled in the art can be used to affect the ability of a hybridization complex to form. These include changes in temperature, ionic concentration, or the inclusion of chemical constituents like formamide that decrease complex stability. It is further possible to distinguish animals heterozygous for the SNP versus those that are homozygous for the same. The method of FRET analysis is well known to the art, and the conditions under which the presence or absence of the SNP would be detected by FRET are readily determinable.
[0108] Suitable sequence methods of detection also include e.g., dideoxy
sequencing-based methods and Maxam and Gilbert sequence (see, e.g., Sambrook and Russell, supra). Suitable HPLC-based analyses include, e.g., denaturing HPLC (dHPLC) as described in e.g., Premstaller and Oefner, LC-GC Europe 1-9 (July 2002); Bennet et al, BMC Genetics 2: 17 (2001); Schrimi et al, Biotechniques 28(4):740 (2000); and Nairz et al, PNAS USA 99(16): 10575-10580 (2002); and ion-pair reversed phase HPLC-electrospray ionization mass spectrometry (ICEMS) as described in e.g., Oberacher et al.; Hum. Mutat. 21(1):86 (2003). Other methods for characterizing single base changes in alleles of genetic markers include, e.g., single base extensions (see, e.g., Kobayashi et al, Mol. Cell. Probes, 9: 175-182, 1995); single-strand conformation polymorphism analysis, as described, e.g, in Orita et al, Proc. Nat. Acad. Sci. 86, 2766-2770 (1989), allele specific oligonucleotide hybridization (ASO) (e.g., Stoneking et al, Am. J. Hum. Genet. 48:70-382, 1991 ; Saiki et al, Nature 324, 163-166, 1986; EP 235,726; and WO 89/1 1548); and sequence-specific amplification or primer extension methods as described in, for example, WO 93/22456; U.S. Pat. Nos. 5, 137,806; 5,595,890; 5,639,61 1 ; and U.S. Pat. No. 4,851 ,331 ; 5*- nuclease assays, as described in U.S. Pat. Nos. 5,210,015; 5,487,972; and 5,804,375; and Holland et al, 1988, Proc. Natl. Acad. Sci. USA 88:7276-7280.
[0109] Methods for detecting single base changes well known in the art often entail one of several general protocols: hybridization using sequence-specific oligonucleotides, primer extension, sequence-specific ligation, sequencing, or electrophoretic separation techniques, e.g., singled-stranded conformational polymorphism (SSCP) and heteroduplex analysis. Exemplary assays include 5' nuclease assays, template-directed dye-terminator incorporation, molecular beacon allele-specific oligonucleotide assays, single-base extension assays, and SNP scoring by real-time pyrophosphate sequences. Analysis of amplified sequences can be performed using various technologies such as microchips, fluorescence polarization assays, and matrix-assisted laser desorption ionization (MALDI) mass spectrometry. In addition to these frequently used methodologies for analysis of nucleic acid samples to detect single base changes, any method known in the art can be used to detect the presence of the genetic markers described herein.
[0110] For example FRET analysis can be used as a method of detection.
Conveniently, hybridization probes comprising an anchor and detection probe, the design of which art is well known to those skilled in the art of FRET analysis, are labeled with a detectable moiety, and then under suitable conditions are hybridized an amplification product containing the genetic marker of interest in order to form a hybridization complex. A variety of parameters well known to those skilled in the art can be used to affect the ability of a hybridization complex to form. These include changes in temperature, ionic concentration, or the inclusion of chemical constituents like formamide that decrease complex stability. The presence or absence of the genetic marker is then determined by the stability of the hybridization complex. The parameters affecting hybridization and FRET analysis are well known to those skilled in the art. The amplification products and hybridization probes described herein are suitable for use with FRET analysis.
6. Methods of Analyzing Biomarkers
[0111] The methods comoprise determining the contributions of one or more feline populations (e.g., ancestral lineage and/or breed contributions) to the test feline genome by comparing the alleles at the predetermined genetic markers in the test feline genome (e.g. , a plurality of the SNPs listed in Table 1; optionally one or more phenotypic markers and/or microsatellite markers) to a database comprising feline population profiles, wherein each feline population profile comprises genotype information for alleles of the markers in the set of markers in the feline population. For example, a feline population profile may comprise genotype information for each allele of each marker in the set of markers in the feline population. The genotype information in a feline population profile may comprise information such as the identity of one or both alleles of most or all of the markers in the set of markers in one or more felines that are members of that feline population, and/or estimated allele frequencies for at least one allele of most or all of the markers in the set of markers in that feline population. The collection of feline population profiles can be collected in a database for use in practicing the invention. In some embodiments, the database of feline population profiles comprises one or more feline population profiles. In various embodiments, the database of feline population profiles comprises a plurality of feline population profiles, e.g., between about five and about 500 feline population profiles, such as about 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, or more, feline population profiles.
[0112] Determining the contributions of feline populations to the test feline genome can encompass both assigning a feline genome to one or more particular feline populations and/or determining the fraction of the feline genome that was derived from one or more feline populations. In one embodiment, the test feline is suspected of having at least about 25% of the feline genome, e.g., at least about 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100%), derived from a single defined feline population (e.g., ancestral lineage and/or breed).
[0113] Many methods of assignment testing have been developed in the past decade using common population genetic markers and a variety of statistical methods (Rannala & Mountain (1997) Proc Natl Acad Sci USA. 94(17):9197-9201 ; Pritchard et al. (2000) Genetics, 155:945-959; Baudouin & Lebrun (2001) In: Proc. Int. Symp. on Molecular Markers, pp. 81-94; Paetkau et al. (2004) Molecular Ecology , 13:55-65). These methods have been applied to various breeding populations including pigs, cattle, and dogs
(Schelling et al. (2005) Journal of Animal Breeding and Genetics, 122:71-77; Negrini et al. (2009) Animal Genetics, 40: 18-26; Boitard et al. (2010) Anim Genet. 2010 41(6):608-18. See also, U.S. Patent Nos. 7,729,863 and 6,770,437. In some embodiments of the method, a Bayesian model-based clustering approach is used, e.g. , as described by Rannala &
Mountain, supra; Pritchard, supra; and/or Baudouin & Lebrun, supra.
[0114] There are two broad classes of clustering methods that are used to assign individuals to populations (Pritchard, supra). Distance-based methods calculate a pairwise distance matrix to provide the distance between every pair of individuals. Model-based methods proceed by assuming that observations from each cluster are random draws from some parametric model; inference for the parameters corresponding to each cluster is then done jointly with inference for the cluster membership of each individual, using standard statistical methods. In some embodiments of the method, a likelihood or frequentist model- based approach is used, e.g., as described by Paetkau, supra; and/or Negrini, supra. Any standard statistical method may be used in the methods of the invention, including maximum likelihood, bootstrapping methodologies, Bayesian methods and any other statistical methodology that can be used to analyze genotype data. These statistical methods are well-known in the art. [0115] Many software programs for population genetics studies have been developed and may be used in the methods of the invention, including, but not limited to TFPGA, Arlequin, GDA, GENEPOP, GeneStrut, POPGENE (Labate (2000) Crop. Sci. 40: 1521-1528), Geneclass2 (Piry et al, (2004) Journal of Heredity 95, 536-539) and STRUCTURE (Pritchard et al. (2000) Genetics 155:945-59).
[0116] An exemplary Bayesian model-based clustering approach is provided by the genotype clustering program STRUCTURE (Pritchard et al. (2000) Genetics 155:945-59), which has proven useful for defining populations within a species (Rosenburg et al. (2001) Genetics 159:699-713; Rosenburg et al. (2002) Science 298:2381-5; Falush et al. (2003) Genetics 164(4): 1567-87). The clustering method used by STRUCTURE requires no prior information about either phenotype or genetic origin to accurately place an individual or set of related individuals in a population.
[0117] Any algorithms useful for multi-locus genotype analysis may be used in the methods of the invention, for example, classic assignment algorithms. Suitable algorithms include those described in Rannala & Mountain (1997) Proc. Natl. Acad. Sci. U.S.A. 94:9197-9201, Paetkau et al. (2004) Molecular Ecology, 13:55-65 and Cornuet et al.
(1999) Genetics 153: 1989-2000 and variations thereof. Exemplary programs available for multi-locus genotype analysis include Doh (available on the internet at
biology .ualberta.ca/jbrzusto/Doh.php) and GeneClass (available at montpellier.inra.fr/URLB/geneclass/genecass.htm). Cluster iterations can be combined, e.g., through the program CLUMP (Jakobsson & Rosenberg, Bioinformatics 23(14): 1801-6) and DISTRUCT (Rosenberg, (2004) Molecular Ecology Notes 4, 137-138) to create a consensus clustering. Migrants within populations can be detected, e.g., using the program Geneclass2 (Piry et al, (2004) Journal of Heredity 95, 536-539.
[0118] In some embodiments, the methods of the invention comprise determining the probability that a specific feline population contributed to the genome of the test feline by determining the conditional probability that the alleles in the test feline genome would occur in the specific feline population divided by the sum of conditional probabilities that the alleles in the test feline genome would occur in each feline population in the database.
[0119] Some embodiments of the methods of the invention comprise discriminating between the contributions of two or more genetically related feline populations to the test feline genome by comparing the alleles in the test feline genome to a database comprising profiles of the two or more genetically related feline populations. In various embodiments, the two or more genetically related feline populations may comprise (i) Persian and Exotic Shorthair (SH); (ii) British SH and Scottish Fold; (iii) Australian Mist and Burmese;
(iv) Singapura and Burmese; (v) Birman and Korat, and (vi) Siamese and Havana Brown.
[0120] Using an assignment algorithm on genotype information for all 148 SNPs listed in Table 1, 38 microsatellite markers and 5 phenotypic markers listed in Table 3 from 477 felines representing 29 feline breeds, the methods of the invention have been used to assign individual test felines to its breed with at least about 50% sensitivity and specificity, for example, at least about 60%, 70%, 75%, 80%, 85%, 90%, 95% sensitivity and specificity, or greater. As used herein, sensitivity specifically indicates the percentage of individuals sampled from a breed that could be assigned back to that breed. Specificity takes into account individuals sampled from other breeds that were misassigned to that breed. Sensitivity and specificity are properly used to describe the power of the testing in assignment testing. See, Example 2.
[0121] The methods of the invention are also useful for determining the
contributions of feline populations to felines having genetic contributions from more than one breed or defined ancestral lineage. Preferably, the test feline has at least 25% of the markers, e.g., at least about 30%, 40%, 50%, 60%, 70%, 80%, 90% or 100% of the markers, associated with a defined ancestral lineage or breed. Models that detect an individual's admixed state can be considered to group into two classes: models that require a combinatoric set of unique alleles for each of the possible mixtures of ancestral populations (Nason & Ellstrand (1993) J. Hered. 84: 1-12; Epifanio & Philipp (1997) J. Hered. 88:62- 5), and Bayesian methods where ancestral populations are not required to contain a combination describing unique alleles, but instead assign individuals to admixed states probabilistically based on differences in allele frequencies between populations (Corander et al. (2003) Genetics 163(1): 367-74; Anderson & Thompson (2002) Genetics 160: 1217- 29, Pritchard et al. (2000) Genetics 155:945-59, Rannala & Mountain (1997) Proc. Natl. Acad. Sci. U.S.A. 94:9197-9201. The latter set of models are more informative for most populations and data sets as they allow for a Bayesian posterior probabilistic assignment vector for each population/generation combination, thereby allowing for uncertainty analysis to be incorporated into the assignment vector; but existing models for the exact, recent admixture assignments of individuals from multiple ancestral populations are limited in their scope as they have been developed thus far only for two generation prediction and allow for only a few ancestral populations. For example, the methods of Anderson & Thompson (2002) are developed for a two generation, two population model with unlinked microsatellite data.
7. Reporting Results of Analysis
[0122] In various embodiments, the methods may further comprise the step of reporting the results of the assignment analysis, e.g., to the purchaser, to the owner or guardian of the feline, to a breed registry, to a veterinarian or another interested individual. The methods may further comprise the step of providing a document displaying the contributions of one or more feline populations to the genome of the test feline genome. The document may be a chart, certificate, card, or any other kind of documentation. The document may be electronic or paper copy. The document may display the contributions of one or more feline populations to the test feline genome in a numeric format or in a graphic format. For example, the document may include photographs or other depictions, drawings, or representations of the one or more feline populations. The document may also provide confidence values for the determined contributions (such as 80%, 85%, 90%> 95%, or 99% confidence). In some embodiments, the document provides a certification of the
contributions of one or more feline populations to the genome of the test feline genome.
[0123] In some embodiments, the document additionally provides information regarding the one or more feline populations that contributed to the genome of the test feline or the test feline. The information regarding feline populations that contributed to the genome of the test feline may include information related to the characteristics and origin of the feline population (e.g., ancestral origin and/or contributing breed(s)) or any other kind of information that would be useful knowledge concerning the test feline. In some
embodiment, the information includes health-related information. Many feline populations have predispositions to particular diseases or conditions. For example, heart disease in the Maine Coon and Ragdoll (Meurs et al. (2005) Human Molecular Genetics, 14:3587-3593; Meurs et al. (2007) Genomics, 90:261-264), polycystic kidney disease in the Persian (Lyons et al. 2004, supra), progressive retinal atrophy in the Abyssinian (Menotti- Raymond et al. (2007) Journal of Heredity, 98:211-220) and a craniofacial defect and hypokalemia in Burmese. Therefore, information regarding the contributions of one or more feline populations to the genome of the test feline genome is particularly valuable to mixed-breed feline owners or caretakers (both professional and non-professional) for the purpose of proactively considering health risks for individual tested animals. For example, a mixed breed cat that is found to be a mixture of a breed with known association or predisposition for certain disease conditions could be proactively monitored for such disease conditions that occur with rare frequency in the general population of cats, but occur with significant frequency in these specific breeds.
[0124] Health-related information may also include potential treatments, special diets or products, diagnostic information, and insurance information.
8. Computer-Readable Media
[0125] In a further aspect, the invention provides one or more computer-readable media comprising a data structure stored thereon for use in distinguishing feline
populations. In some embodiments, the data structure comprises: a marker field, which is capable of storing the name of a marker (for example, an SNP marker) or the name of an allele of a marker; and a genotype information field, which is capable of storing genotype information for the marker (for example, the identity of one or both alleles of the marker in a feline genome or an estimate of the frequency of an allele of the marker in a feline population), wherein a record comprises an instantiation of the marker field and an instantiation of the genotype information field and a set of records represents a feline population profile.
[0126] A "computer-readable medium" refers to any available medium that can be accessed by computer and includes both volatile and nonvolatile media, removable and nonremovable media. Computer readable media that are non-transitory find use. By way of example, and not limitation, computer-readable media may comprise computer storage media and communication media. Computer storage media includes both volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information, such as computer-readable instructions, data structures, program modules, or other data. Computer storage media include, but are not limited to, RAM, ROM, EEPROM, flash memory or other memory technology, CD-ROM, digital versatile disks (DVD) or other optical disk storage, magnetic cassettes, magnetic tapes, magnetic disk storage or other magnetic storage devices, or any other computer storage media. Communication media typically embody computer-readable instructions, data structures, program modules or other data in a modulated data signal, such as a carrier wave or other transport mechanism that includes any information delivery media. The term "modulated data signal" means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal. By way of example, and not limitation, communication media include wired media, such as a wired network or direct- wired connection, and wireless media, such as acoustic, RF infrared, and other wireless media. A combination of any of the above should also be included within the scope of computer-readable media.
[0127] A "data structure" refers to a conceptual arrangement of data and is typically characterized by rows and columns, with data occupying or potentially occupying each cell formed by a row-column intersection. In some embodiments, a data structure in the computer-readable medium can comprise a marker field and a genotype information field, as described above. The instantiation of the marker field and the genotype information field provides a record, and a set of record provides a feline population profile. Thus, the data structure may be used to create a database of feline population profiles.
[0128] In some embodiments, the computer readable medium comprises a substrate having stored thereon: (a) a data structure for use in distinguishing feline populations, the data structure comprising: (i) a marker field, which is capable of storing the name of a marker or of an allele of a marker; and (ii) a genotype information field, which is capable of storing genotype information for the marker, wherein a record comprises an instantiation of the marker field and an instantiation of the frequency field and a set of records represents a feline population profile; and (b) computer-executable instructions for implementing a method for determining the contributions of feline populations to a feline genome, comprising: (i) obtaining the identity of one or both alleles in a test feline genome for each marker of a set of markers; and (ii) determining the contributions of feline populations to the test feline genome by comparing the alleles in the test feline genome to a database comprising feline population profiles, wherein each feline population profile comprises genotype information for the set of markers in the feline population.
9. Kits
[0129] In another aspect, the invention provides nucleic acid sequences for determining the identity of one or both alleles in a feline genome for each marker of a set of markers, e.g., as listed in Table 1. The nucleic acid sequences can be primer sets. In some embodiments, the primer sets are provided in a kit.
[0130] The invention further provides kits useful for determining the population of origin {e.g., ancestral lineage and/or breed contributions) of a feline. In general, the kits comprise one or more oligonucleotide primer pairs as described herein suitable to amplify the portions of a feline genome comprising a plurality of the SNPs listed in Table 1. In some embodiments, the kit comprises oligonucleotide primer pairs for determining all 148 SNPs listed in Table 1. In various embodiments, the kits may further comprise one or more oligonucleotide primer pairs for determining one or more biomarkers listed in Table 3, e.g., for determining the SNPs in one or more of SEQ ID NOs: 149-202. The kits comprise forward and reverse primers suitable for amplification of a genomic DNA sample taken from a feline. As described above, the biological sample can be from any tissue or fluid in which genomic DNA is present. Conveniently, the sample may be taken from blood, skin {e.g., cheek swab) or a hair bulb.
EXAMPLES
[0131] The following examples are offered to illustrate, but not to limit the claimed invention. Example 1
Genetic Structure of Worldwide Random Bred Cat Populations
[0132] This example describes the specific pinpointing of the geographic source of domestic cats. For this study, 944 cats from 37 random bred worldwide populations particularly from within the Middle East, Egypt and other Old World areas were genotyped at 148 SNPs and 38 cat-specific STRs. Thirty-eight wildcats were examined as outgroups. Principal Coordinate Analysis (PCA) and Bayesian clustering methods indicated eight modern worldwide cat populations belonging to at least five distinct ancestral groups;
populations were geographically distributed, consistent with isolation by distance. Genetic indices were a gradient across the world, with the highest genetic diversity and lowest inbreeding in the region of historical Mesopotamia and the Levant, current day Iraq, Lebanon and Israel of the 37 sampled locations, more so than cats from Egypt, suggesting cats shared their cradle of domestication with the earliest human civilization and only later branching out towards Europe and Asia.
Materials and Methods:
[0133] Cat Sample Collection. This study included 944 domestic cats from 37 locations worldwide, including 20 locations and 481 cats novel to this study (Figure 1). Samples (n = 463) from a previous study included random bred cats from 17 locations (Lipinski et al, (2008) Genomics 91, 12-21). Samples were collected via buccal (cheek) swabs and extracted with a QIAamp DNA blood mini kit following the manufacturer's protocol (Qiagen, Valencia, CA, USA), or as whole blood spotted onto an FTA Card (Whatman International Ltd.) followed by a modified whole genome amplification
(REPLI-g Mini Kit, Qiagen) as follows. A 0.12 cm punch was taken from the bloodstained card and washed with 5 minutes of gentle rocking a total of 5 times: 3 times with 0.5 ml of FTA purification mix made out of one part FTA-Reagents (Whatman International Ltd.), two parts PBS and 0.5% TWEEEN, and 2 washes with 0.5 mL of lx TE Buffer (10 mL Tris HC1 1M, 2 mL EDTA 0.5M). This was dried at 60°C for 30 min. Two clean, dry punches were combined with 2.5 μΐ PBS and processed following the REPLI-g whole genome amplification kit protocol for amplification of genomic DNA from blood or cells (Qiagen, Valencia, CA, USA). Following whole genome amplification, consumed punches were discarded. Wildcat samples (N=38) were collected as part of other studies and provided as extracted DNA that had been whole genome amplified.
[0134] SNP and STRs. Thirty-eight autosomal STRs were genotyped following the
PCR and analysis procedures of a previous study (Lipinski et al., 2008, supra). Unlinked non-coding autosomal SNPs (n=169), which were defined by one Abyssinian cat, were selected to represent all autosomes from the 1.9x coverage cat genomic sequence (Pontius, et al., 2007, (2007) Genome Research 17, 1675-1689). Primers were designed with the
VeraCode Assay Designer software (Illumina Inc., San Diego, CA, USA). Only SNPs that received a design score of 0.75 or higher (with a mean design score of 0.95) (n = 162) were included in the analysis (Table 6). [0135] Golden Gate Assay amplification and BeadXpress reads were performed per the manufacturer's protocol (Illumina Inc.) on 50-500ng of DNA or whole genome amplified product. BeadStudio software v. 3.1.3.0 with the Genotyping module v. 3.2.23 (Illumina Inc.) was used to analyze the data. Any samples with a call rate less than 0.80 (n = 21) were removed from further clustering analysis. Additionally, only SNPs with a Gentrain Score of > 0.55 (n = 148) were included in the study (Table 6).
Table 6
SNPs for the analysis of worldwide random bred cat populations.
Minor Allele
Locus Name Call Frequency Frequency Gentrain Score Desiqi chrA1_10141047 0.753 0.099 0.8314 0.967
chrA1_133621071 0.822 0.316 0.6292 0.851
chrA1_151648701 0.82 0.161 0.9071 0.872
chrA1_175780586 0.745 0.257 0.797 0.908
chrA1_208054462 0.788 0.094 0.8803 1
chrA1_223501140 0.777 0.201 0.9354 0.979
chrA1_223506906 0.775 0.168 0.7732 0.911
chrA1_225057933 0.824 0.179 0.9035 0.934
chrA1_235579538 0.782 0.066 0.9023 0.953
chrA1_264488084 - - < 0.55 0.952
chrA1_27523501 0.816 0.408 0.7117 0.98
chrA1_68485376 0.806 0.116 0.6293 0.953
chrA1_69424718 0.796 0.369 0.8457 0.95
chrA1_7429296 0.755 0.121 0.933 0.976
chrA1_8742286 0.826 0.264 0.9066 0.9
chrA2_152258936 0.807 0.266 0.7745 0.941
chrA2_18603206 - - < 0.55 0.909
chrA2_201526186 0.822 0.253 0.9045 0.967
chrA2_202225770 0.794 0.222 0.9004 0.955
chrA2_44241149 0.834 0.014 0.8447 0.919
chrA2_554046 0.806 0.105 0.8098 0.754
chrA2_63928585 - - <0.55 0.977
chrA3_101420069 0.825 0.036 0.9005 0.949
chrA3_11480952 0.756 0.017 0.8013 0.847
chrA3_12082294 0.813 0.148 0.8723 0.941
chrA3_130195244 0.765 0.126 0.9275 0.915
chrA3_159537633 0.812 0.382 0.9266 0.986
chrA3_162208567 0.768 0.278 0.8971 0.959
chrA3_38781591 0.818 0.06 0.6781 0.913
chrA3_75156179 0.808 0.28 0.8108 0.991
chrA3_91058022 0.808 0.208 0.8533 0.969
chrA3_99507784 0.817 0.223 0.7373 0.94
chrB1_10420438 0.812 0.168 0.8177 0.973
chrB1_12214271 0.813 0.302 0.9113 0.977
chrB1_173872554 - - < 0.55 0.984
chrB1_195678303 0.82 0.122 0.8838 0.958
chrB1_199564532 0.816 0.068 0.8779 0.967
chrB1_202966562 0.807 0.304 0.9003 0.921
chrB1_54775572 0.826 0.086 0.7206 0.932 Table 6
SNPs for the analysis of worldwide random bred cat populations.
Minor Allele
Locus Name Call Frequency Frequency Gentrain Score Desiqn Score chrB1_80161671 0.755 0.158 0.8431 0.971 chrB1_88148379 0.811 0.272 0.881 0.954 chrB2_138312489 0.816 0.315 0.9085 0.972 chrB2_146660650 0.834 0.013 0.9346 0.932 chrB2_165334691 - - < 0.55 0.978 chrB2_41509834 0.8 0.252 0.8068 0.988 chrB2_44611679 - - < 0.55 0.902 chrB2_45093345 0.779 0.252 0.8423 0.842 chrB2_6949528 0.824 0.096 0.9261 0.955 chrB3_104483970 0.818 0.223 0.8287 0.924 chrB3_111000326 0.827 0.129 0.8451 0.97 chrB3_13666494 0.813 0.337 0.8875 0.949 chrB3_144896949 - - < 0.55 0.93 chrB3_39203469 0.807 0.151 0.8987 0.91 chrB3_51317931 0.806 0.204 0.7156 0.96 chrB3_57141954 0.79 0.31 0.8199 0.814 chrB3_77094074 0.762 0.135 0.9005 0.945 chrB4_105706694 0.795 0.371 0.8855 0.936 chrB4_142658074 0.796 0.094 0.666 0.953 chrB4_143006494 0.79 0.18 0.8963 0.915 chrB4_144693308 0.806 0.267 0.925 0.906 chrB4_146486983 0.817 0.187 0.9402 0.978 chrB4_147206961 0.738 0.232 0.87 0.965 chrB4_149532846 0.756 0.108 0.856 0.992 chrB4_1687419 0.696 0.036 0.8797 0.992 chrB4_20001848 0.813 0.05 0.8896 0.983 chrB4_21098349 0.779 0.278 0.8934 0.929 chrB4_255106 0.8 0.154 0.8312 0.964 chrB4_3093827 0.812 0.094 0.9242 0.935 chrB4_40319102 0.79 0.363 0.8632 0.981 chrB4_47638578 0.813 0.084 0.9279 0.923 chrC1_104161375 - - < 0.55 0.909 chrC1_116355295 0.821 0.196 0.6692 0.924 chrC1_123164748 0.813 0.148 0.8197 0.94 chrC1_181852965 0.389 0.11 0.9008 0.954 chrC1_190502133 0.825 0.254 0.7788 0.968 chrC1_214768780 - - < 0.55 0.94 chrC1_215441574 0.794 0.255 0.863 0.956 chrC1_216852686 0.694 0.198 0.9473 0.958 chrC1_23778400 - - < 0.55 0.957 chrC1_24148281 0.811 0.143 0.8695 0.987 chrC1_28702055 0.819 0.168 0.9367 0.901 chrC1_34981315 0.814 0.031 0.8551 0.937 chrC1_396397 0.785 0.178 0.7129 0.976 chrC1_44520932 0.796 0.053 0.9208 0.982 chrC1_52456776 0.747 0.339 0.9 0.987 chrC2_106991233 0.802 0.302 0.8821 0.983 chrC2_147124460 0.824 0.394 0.8973 0.99 chrC2_150774106 0.821 0.046 0.7475 0.976 chrC2_156491175 0.799 0.376 0.8444 0.944 Table 6
SNPs for the analysis of worldwide random bred cat populations.
Minor Allele
Locus Name Call Frequency Frequency Gentrain Score Desigi chrC2_187325 0.689 0.116 0.7213 0.936 chrC2_262401 0.771 0.176 0.8529 0.981 chrC2_5215469 0.806 0.268 0.8223 0.958 chrC2_955732 - - < 0.55 0.947 chrD1_101321498 0.802 0.226 0.9247 0.904 chrD1_104941557 0.816 0.148 0.8874 0.956 chrD1_105498119 0.798 0.084 0.8834 0.942 chrD1_10789012 0.818 0.231 0.8845 0.904 chrD1_11484008 0.797 0.095 0.8929 0.922 chrD1_117527468 0.823 0.093 0.8557 0.931 chrD1_125811329 0.761 0.166 0.7921 0.906 chrD1_126256993 0.815 0.202 0.8932 0.977 chrD1_126847301 0.804 0.06 0.8391 0.96 chrD1_15984279 0.806 0.256 0.8615 0.964 chrD1_16242433 0.728 0.178 0.8532 0.988 chrD1_17005687 - - < 0.55 0.955 chrD1_18390852 0.816 0.213 0.933 0.902 chrD1_18570323 0.811 0.279 0.9196 0.943 chrD1_66177762 0.813 0.073 0.7002 0.974 chrD2_1020904 0.82 0.383 0.7066 0.922 chrD2_103984864 - - < 0.55 0.933 chrD2_105772916 0.808 0.211 0.8808 0.996 chrD2_1752007 0.81 0.09 0.8115 0.991 chrD2_56777338 0.832 0.004 0.7186 0.949 chrD2_717969 0.771 0.263 0.8805 0.932 chrD2_74293444 0.784 0.134 0.8692 0.985 chrD2_91989307 0.817 0.165 0.8417 0.945 chrD3_103840114 0.829 0.029 0.8386 0.867 chrD3_122502120 0.807 0.173 0.7726 0.982 chrD3_1810839 0.515 0.191 0.8856 0.951 chrD3_24565823 0.827 0.057 0.7063 0.93 chrD3_24823793 0.792 0.128 0.8819 0.901 chrD3_28838660 0.824 0.057 0.8921 0.968 chrD4_41078218 0.77 0.301 0.8384 0.84 chrD4_42000379 0.785 0.055 0.8177 0.941 chrD4_63622083 0.786 0.196 0.886 0.937 chrE1_130875919 0.803 0.09 0.6753 0.947 chrE1_131587399 0.762 0.146 0.8134 0.966 chrE1_3912105 0.81 0.119 0.9033 0.997 chrE1_4114158 0.81 0.366 0.8524 0.997 chrE1_48228153 0.814 0.155 0.8877 0.963 chrE1_48700963 0.828 0.043 0.8647 0.981 chrE1_5453028 0.822 0.347 0.9203 0.947 chrE2_22632289 0.804 0.298 0.8704 0.989 chrE2_34027888 0.807 0.168 0.6515 0.994 chrE2_35914023 0.805 0.152 0.906 0.834 chrE2_36986631 0.815 0.361 0.927 0.968 chrE2_38860686 0.811 0.212 0.7932 0.989 chrE2_39211557 0.651 0.24 0.6053 0.964 chrE2_65436639 0.818 0.253 0.9099 0.937 Table 6
SNPs for the analysis of worldwide random bred cat populations.
Minor Allele
Locus Name Call Frequency Frequency Gentrain Score Design Score chrE2_7950477 0.8 0.347 0.6547 0.989
chrE2_8422942 0.771 0.115 0.8173 0.96
chrE3_36044809 0.81 0.256 0.8796 0.833
chrE3_42164232 - - < 0.55 0.967
chrE3_55434272 0.782 0.241 0.7735 0.936
chrE3_67006512 0.681 0.071 0.8178 0.96
chrF1_20309325 0.824 0.059 0.7635 0.983
chrF1_21799641 0.824 0.122 0.8749 0.937
chrF1_26100599 0.804 0.271 0.8394 0.951
chrF1_27124984 0.814 0.213 0.9122 0.929
chrF1_38051725 0.819 0.331 0.9303 0.993
chrF1_565223 0.802 0.348 0.8739 0.958
chrF1_82068276 0.682 0.157 0.7686 0.91
chrF1_82716202 0.81 0.253 0.8563 0.943
chrF1_91517402 0.809 0.166 0.7746 0.933
chrF2_26886470 0.799 0.198 0.8643 0.957
chrF2_38395360 0.801 0.317 0.877 0.993
chrF2_46855978 0.808 0.277 0.7193 0.963
chrF2_68572596 0.796 0.191 0.8183 0.956
chrF2_74863327 0.82 0.18 0.9059 0.976
chrF2_78303221 0.812 0.4 0.911 0.911
chrF2_79632602 0.827 0.019 0.9445 0.959
chrF2_8427817 0.695 0.302 0.8707 0.955
Locus name includes the chromosome and location of each SNP.
[0136] Data analysis. Data sets were analyzed with the Bayesian clustering program STRUCTURE (Pritchard et al, (2000) Genetics 155, 945-959) under the admixture model with correlated allele frequencies and a burn-in of 100,000 with 100,000 additional iterations. Values of K were calculated from K = 1 to K = 25, each run was replicated 10 times. Posterior log likelihoods were used in the calculation of ΔΚ in order to best estimate the number of ancestral populations through the program Harvester (Evanno et al, (2005) Molecular Ecology 14, 2611-2620) (Figure 2). To assess the effects of varying marker types on the final results, STRUCTURE analysis was conducted on the data in three different permutations: only SNPs, only STRs, and SNPs and STRs together.
Images were created with CLUMPP v. 1.1.2 (Jakobsson and Rosenberg, (2007)
Bioinformatics 23(14): 1801-6) to combine replicates and DISTRUCT v. 1.1 (Rosenberg, (2004) Molecular Ecology Notes 4, 137-138) to create final images. A map of cat domestication was created using an inverse distance function. Each point on the map has an interpolated likelihood for each cluster; the color is the most likely cluster. Color saturation is based on the value of the likelihood (e.g. low saturation means low likelihood)
(Figure 1).
[0137] First generation migrants within populations identified by STRUCTURE were detected with the program Geneclass2 (Piry et al, (2004) Journal of Heredity 95, 536- 539) under the Rannala and Mountain (Proc Natl Acad Sci USA. (1997) 94(17):9197-201) Bayesian model, with 1000 Monte-Carlo re-sampling simulations (Paetkau et al., (2004) Molecular Ecology 13, 55-65), and the p-value threshold set at 0.01. From both STRs and SNPs, samples that were below the threshold of 0.01 for originating from the same lineage as that assigned for the majority of the cats from the same sampling location were considered recent immigrants and removed from subsequent analyses. These individuals were compared to the first generation migration test applied to the output from
STRUCTURE as in previous studies (Randall et al, (2010) Conservation Genetics 11, 89- 101), where individuals that clustered with a lineage other than that of the majority of their sampling location with a posterior probability of >0.5 were considered to be first generation immigrants to that sampling location (n = 56). All migrants were removed from further analyses (n = 63). FIS was calculated with Fstat v. 2.9.3.2 (Goudet, (1995) J Hered (1995) 86(6): 485-486) and observed and expected heterozygosites with GenAlEx v.6.3 (Peakall, Smouse, (2006) Molecular Ecology Notes 6, 288-295). F-statistics were calculated both by sampling location and based on the populations as assigned by STRUCTURE.
[0138] Principal coordinates analyses were conducted on a matrix of Nei's unbiased genetic distance and plotted via the standardized co-variance using the software GenAlEx (Peakall, Smouse, 2006, supra).
[0139] Phylogenetic trees were created with the software package PHYLIP version
3.67 (Felsenstein, (1989) Cladistics 5, 164-166). Allele frequencies for each data set were analyzed sequentially with SeqBoot, Genedist, Neighbor, and Consense to create a consensus tree. Trees were replicated with 1,000 bootstraps; genetic distance was calculated following Nei's unbiased method (Nei, Roychoudhury, (1974) Genetics 1 '6:379- 390) with the STRs to account for not only genetic drift, but also the fast mutation rate of the markers. The method of Reynolds et al. (Reynolds et al, (1983) Genetics 105, 767- 779) was applied to the SNP data to account for genetic drift only. Final unrooted trees were produced with the neighbor-joining method and visualized with FigTree vl .3.1 (on the internet at tree.bio.ed.ac.uk/software/figtree). Results:
[0140] The final analyses consisted of cat DNA samples (n = 944) from worldwide populations, including 463 domestic cats used previously (Lipinski et al, 2008, supra), and 481 domestic cat samples collected from 20 additional locations in the Middle East, Kenya, India, and Japan (Figure 1). Thirty-eight wildcats of known genetic origin (F. silvestris silvestris (Western Europe), F. s. libyca (assorted African locations), and F.s. tristrami (Israel)) (Lipinski et al, 2008, supra) were used as outgroups for the analyses. The 38 STRs had an average call rate of 92.3% and the 148 SNPs had an average call rate of 95.5%.
[0141] Bayesian clustering suggested a value of K = 5 (Figure 2) for both SNPs and
STRs resulting in five groupings corresponding to Europe, Mediterranean (including Western portions of the Middle East), Iraq/Iran, South Asia, and East Asia (Figure 3A, C) (alternate plots are available as Figure 4). The sampling locations along the Indian Ocean, including India and Sri Lanka, appeared to be admixtures of all five ancestral lineages, which are more strongly depicted by the STR data (Figure 3C). A secondary peak in ΔΚ values was observed at K=7 in the STRs and K=8 in SNPs, however, the two marker types resolved with some discrepancies (Figure 3B, D). SNPs and STRs both separated the Egyptian cats from the other Mediterranean cats, STRs indicating a stronger distinction (Figure 3D) than the SNPs (Figure 3B). STRs additionally indicated the Arabian Sea (Dubai, Pate, and Lamu), to be distinct from the cats of India, Sri Lanka and Southern Asia (Thailand and Vietnam). SNPs were able to discern the Arabian Sea cats and the Southern Asian cats as distinct populations but maintained the cats of India as highly admixed.
[0142] When SNPs and STRs were combined for analysis, a consensus of both the individual SNP and STR analyses is observed, suggesting five distinct ancestral lineages (Figure 3E) and eight modern populations (Figure 3). The division between the Arabian Sea and the Indian populations is supported by the STR data, but not the SNP data set, while the division between Indian and South Asian populations is supported by the SNP but not the STR data. Besides the Indian cats, the cats from Taiwan and Sapporo, Japan have the most amount of admixture.
[0143] When analyzed for first generation migrants, 21 individuals had a p-value of less than 0.01 indicating that these cats were likely not native to the sampling location. Additionally, detection of first generation migrants using the posterior probabilities of assignment with STRUCTURE detected 56 individuals (42 additional migrants), for a combined total of 63 individuals when the cats from the two methods were combined (Table 7). Europe is the source for a majority of the migrant cats that are found in other parts of the world (33%). The remainder of migrant cats appears to have traveled a short distance to adjoining populations. Individuals that were categorized as first generation migrants were removed from further analyses.
Table 7
First generation migration test of eight worldwide cat populations*.
Total First Generation Migrants from Each Source
Sampling East South East
Lineage location Europe Mediterranean Egypt Iraq/Iran India Asia Asia
Europe Germany 1
Italy-Milan 4
Kenya-Nairobi 1 1
East
Mediterranean Turkey 2 1 4
Cyprus 4
Lebanon 1 6 1
Israel 2
Egypt Cairo 6 2 1
Luxor 1
Arabian Sea Dubai 1 1
India Sri Lanka 1 1
South Asia Vietnam 1
East Asia Taiwan 7 1
Japan-Oita 2
Japan-
Kanazawa 2
Japan-Ohmiya 1
Japan-Sapporo 4 2
South Korea 1
Total N = 63 21 11 12 1 4 13 1
*Number of individuals that were determined migrants with a p-value < 0.01 calculated using Geneclass2 (Peakall, Smouse, 2006, supra). Populations with no detected migrants are not presented.
[0144] Population statistics are presented both for each sampling site (Table 8) and population (Table 9) including the average effective number of alleles, inbreeding coefficients (FIS) and observed heterozygosity (HO) based on SNPs and STRs. No population had a diagnostic / unique SNP. The range of the SNP minor allele frequencies (MAF) throughout the world suggests insignificant ascertainment bias (Table 10). The populations with the highest number of STR alleles were the Mediterranean lineage and the modern Egyptian population, the lowest were found in East Asia. Private alleles were most common in the lineages from the Arabian Sea/ Asia, Mediterranean and Iraq/Iran, and the modern lineages of the Arabian Sea and Iraq/Iran. Table 8
Cat population statistics based on sampling locations*.
Sampling Location n Private FlS (SNP) Fis Ho (SNP) Ho (STR)
(Migrants Alleles (STR)
1
Europe USA-NY 9 2 0.032 0.128 0.312 0.639
(sites=9) USA-MS 10 0 0.026 0.063 0.309 0.68
USA-HI 10 0 0.084 0.142 0.304 0.615
Brazil 29 1 0.014 0.072 0.3 0.652
Finland 11 0 0.174 0.082 0.259 0.628
Germany 28 3 0.209 0.101 0.255 0.626
Italy-Milan 10 1 0.051 0.039 0.316 0.711
Italy-Rome 15 2 0.018 0.098 0.315 0.651
Kenya-Nairobi 34 6 -0.015 0.056 0.336 0.725
Eastern Turkey 44 4 0.118 0.064 0.267 0.689
Mediterr. Basin Cyprus 26 2 0.002 0.078 0.309 0.704
(sites=4) Lebanon 50 4 0.025 0.058 0.298 0.717
Israel-Tel Aviv 44 2 0.006 0.076 0.301 0.751
Egypt Cairo 75 6 0.053 0.107 0.292 0.688
(sites=4) Assuit 10 1 -0.064 0.031 0.298 0.704
Luxor 27 5 -0.008 0.043 0.303 0.745
Abu Simbel 5 1 0.027 0.099 0.286 0.673
Iraq/Iran Iraq-Western 12 1 -0.06 0.102 0.295 0.684
(sites= 3) Baghdad 33 7 -0.025 0.043 0.284 0.721
Iran 110 4 0.045 0.121 0.239 0.646
Arabian Sea Dubai 8 2 0.03 0.024 0.244 0.699
(sites=3) Kenya-Pate 9 0 -0.015 0.056 0.241 0.597
Kenya-Lamu 20 2 0.04 0.118 0.249 0.59
India Udaipur/Agra 15 2 -0.08 0.073 0.268 0.68
(sites=5) Hyderbad 20 2 -0.008 0.103 0.266 0.688
Andhra 23 3 0.02 0.076 0.259 0.665
Kolkata 7 1 0.07 0.144 0.261 0.639
Sri Lanka 24 2 0.015 0.054 0.289 0.719
South Asia Thailand 14 1 0.171 0.153 0.183 0.563
(sites=2) Vietnam 19 0 0.038 0.065 0.261 0.639
East Asia Taiwan 21 0 0.008 0.025 0.287 0.681
(sites=7) Japan-Oita 15 1 0.11 0.101 0.248 0.613
Japan-Kanazawa 13 0 0.1 0.111 0.237 0.604
Japan-Ohmiya 15 0 0.071 0.163 0.259 0.594
Japan-Sapporo 9 0 0.031 0.075 0.26 0.641
China-Henan 20 3 0.012 0.043 0.219 0.627
South Korea 37 0 0.044 0.04 0.246 0.619
Total sites = 37 881 (63) 71 0.275 0.66
*First generation migrants were not included. N = sample size. FIS = average inbreeding coefficient of an individual relative to its source population, H0 = observed heterozygosity. Table 9
Population statistics of worldwide cat populations
Total Private Aver.
Population n Alleles Alleles Ne F,s(SNP) F,s(STR) Ho(SNP) Ho(STR)
Ancient Basal Lineage
Europe 156 452 5 4.908 0.087 0.107 0.302 0.678
Mediterranean 281 516 7 5.466 0.051 0.089 0.293 0.71
Iraq/Iran 155 408 7 4.866 0.038 0.118 0.252 0.682
Arabian
Sea/Asia 159 455 9 5.197 0.102 0.153 0.254 0.657
East Asia 130 402 3 4.299 0.087 0.097 0.249 0.652
Modern Lineage
Europe 156 452 5 4.941 0.087 0.107 0.302 0.678
East
Mediterranean
Basin 164 481 3 5.284 0.053 0.079 0.291 0.715
Egypt 117 447 3 5.353 0.04 0.096 0.295 0.704
Iraq/Iran 155 408 7 4.866 0.038 0.118 0.252 0.682
Arabian Sea 37 288 8 3.802 0.066 0.121 0.245 0.632
India 89 416 4 5.193 0.042 0.122 0.27 0.683
South Asia 33 285 4 3.554 0.112 0.11 0.225 0.617
East Asia 130 402 4 4.442 0.087 0.097 0.249 0.652
*First generation migrants were not included, n = sample size. Aver. Ne = average effective number of alleles FIS = average inbreeding coefficient of an individual relative to its source population, H0 = observed heterozygosity.
Table 10
Minor Allele Frequency based on population
<
Locus
chrA1_10141047 0.108 0.277 0.308 0.260 0.100 .045 .097 .027 chrA1_133621071 0.304 0.222 0.309 0.283 0.189 .316 .129 .108 chrA1_151648701 0.120 0.063 0.056 0.013 0.027 .023 .000 .058 chrA1_175780586 0.423 0.410 0.299 0.085 0.088 .162 .581 .363 chrA1_208054462 0.142 0.138 0.182 0.013 0.014 .055 .125 .090 chrA1_223501140 0.162 0.082 0.074 0.039 0.111 .167 .076 .100 chrA1_223506906 0.154 0.195 0.329 0.367 0.708 .425 .183 .529 chrA1_225057933 0.221 0.218 0.284 0.401 0.000 .259 .139 .437 chrA1_235579538 0.054 0.144 0.090 0.299 0.324 .125 .056 .071 chrA1_27523501 0.574 0.372 0.364 0.255 0.432 .351 .214 .437 chrA1_68485376 0.141 0.076 0.009 0.000 0.000 .006 .015 .014 chrA1_69424718 0.292 0.343 0.332 0.755 0.542 .335 .412 .322 chrA1_7429296 0.183 0.150 0.161 0.244 0.581 .296 .028 .125 chrA1_8742286 0.273 0.406 0.426 0.683 0.257 .476 .514 .303 chrA2_152258936 0.409 0.399 0.319 0.565 0.446 .314 .471 .182 chrA2_201526186 0.207 0.156 0.269 0.161 0.176 .253 .103 .104 chrA2_202225770 0.317 0.319 0.232 0.203 0.108 .440 .672 .338 chrA2_44241149 0.062 0.016 0.009 0.006 0.000 .017 .014 .003 chrA2_554046 0.133 0.169 0.217 0.186 0.027 .144 .028 .236 chrA3_101420069 0.056 0.057 0.065 0.000 0.054 .087 .000 .061 chrA3_11480952 0.053 0.021 0.027 0.000 0.014 .000 .048 .054 chrA3_12082294 0.336 0.171 0.252 0.126 0.095 .063 .103 .119 chrA3_130195244 0.199 0.284 0.368 0.075 0.111 .124 .138 .096 chrA3_159537633 0.528 0.405 0.350 0.301 0.595 .494 .757 .519 chrA3_162208567 0.377 0.194 0.196 0.260 0.068 .064 .016 .139 chrA3 38781591 0.022 0.016 0.004 0.006 0.000 Table 10
Minor Allele Frequency based on population
Figure imgf000083_0001
Locus
.01 1 .000 .000 chrA3_75156179 0.266 0.375 0.348 0.243 0.068 .127 .069 .167 chrA3_91058022 0.484 0.256 0.241 0.104 0.230 .106 .121 .165 chrA3_99507784 0.231 0.302 0.296 0.578 0.162 .355 .456 .41 1 chrB1_10420438 0.104 0.082 0.034 0.023 0.027 .034 .014 .033 chrB1_12214271 0.401 0.392 0.591 0.350 0.514 .554 .333 .437 chrB1_195678303 0.102 0.258 0.230 0.358 0.351 .1 16 .071 .107 chrB1_199564532 0.156 0.101 0.154 0.003 0.027 .052 .000 .028 chrB1_202966562 0.381 0.263 0.198 0.183 0.149 .184 .235 .175 chrB1_54775572 0.188 0.204 0.135 0.059 0.216 .000 .097 .028 chrB1_80161671 0.169 0.096 0.058 0.241 0.068 .122 .097 .069 chrB1_88148379 0.360 0.477 0.483 0.443 0.622 .369 .182 .371 chrB2_138312489 0.422 0.462 0.422 0.282 0.284 .698 .700 .482 chrB2_146660650 0.000 0.000 0.004 0.000 0.014 .034 .139 .010 chrB2_41509834 0.278 0.257 0.155 0.624 0.351 .464 .614 .489 chrB2_45093345 0.542 0.433 0.404 0.093 0.257 .227 .258 .347 chrB2_6949528 0.201 0.195 0.1 1 1 0.029 0.149 .029 .014 .070 chrB3_104483970 0.202 0.328 0.321 0.172 0.122 .506 .855 .420 chrB3_111000326 0.1 1 1 0.200 0.261 0.171 0.149 .333 .676 .260 chrB3_13666494 0.475 0.439 0.504 0.255 0.243 .560 .765 .528 chrB3_39203469 0.184 0.378 0.625 0.21 1 0.108 .071 .100 .138 chrB3_51317931 0.138 0.294 0.276 0.407 0.095 .390 .750 .254 chrB3_57141954 0.377 0.173 0.171 0.242 0.230 .137 .069 .281 chrB3_77094074 0.168 0.006 0.022 0.007 0.139 .056 .067 .059 chrB4_105706694 0.374 0.410 0.397 0.480 0.459 .585 .371 .628 chrB4_142658074 0.108 0.190 0.187 0.066 0.014 .030 .065 .121 chrB4 143006494 0.338 0.344 0.345 0.243 0.097 Table 10
Minor Allele Frequency based on population
Figure imgf000084_0001
Locus
.1 10 .074 .261 chrB4_144693308 0.31 1 0.426 0.460 0.450 0.473 .335 .469 .215 chrB4_146486983 0.193 0.194 0.124 0.288 0.541 .134 .641 .568 chrB4_147206961 0.350 0.276 0.434 0.293 0.176 .544 .750 .291 chrB4_149532846 0.126 0.056 0.030 0.016 0.014 .023 .057 .026 chrB4_1687419 0.108 0.141 0.145 0.013 0.000 .009 .000 .006 chrB4_20001848 0.046 0.008 0.000 0.003 0.000 .029 .029 .014 chrB4_21098349 0.581 0.408 0.375 0.359 0.357 .318 .1 18 .239 chrB4_255106 0.120 0.025 0.065 0.036 0.000 .006 .015 .031 chrB4_3093827 0.109 0.046 0.055 0.000 0.041 .071 .452 .161 chrB4_40319102 0.532 0.530 0.400 0.500 0.270 .440 .182 .188 chrB4_47638578 0.086 0.038 0.004 0.006 0.000 .017 .014 .031 chrC1_116355295 0.332 0.262 0.272 0.203 0.284 .320 .235 .155 chrC1_123164748 0.261 0.237 0.196 0.267 0.000 .229 .242 .120 chrC1_181852965 0.406 0.108 0.167 0.022 0.000 .1 13 .056 .239 chrC1_190502133 0.176 0.381 0.293 0.576 0.306 .215 .028 .127 chrC1_215441574 0.394 0.346 0.272 0.235 0.459 .323 .574 .389 chrC1_216852686 0.356 0.339 0.507 0.312 0.200 .231 .340 .21 1 chrC1_24148281 0.180 0.222 0.209 0.247 0.292 .324 .059 .1 16 chrC1_28702055 0.122 0.041 0.000 0.129 0.027 .029 .043 .024 chrC1_34981315 0.046 0.050 0.099 0.000 0.000 .012 .103 .040 chrC1_396397 0.392 0.313 0.425 0.139 0.230 .109 .030 .096 chrC1_44520932 0.134 0.087 0.137 0.003 0.014 .040 .015 .024 chrC1_52456776 0.342 0.352 0.454 0.747 0.569 .506 .529 .331 chrC2_106991233 0.261 0.250 0.274 0.279 0.068 .335 .578 .402 chrC2_147124460 0.516 0.492 0.556 0.416 0.568 .362 .186 .086 chrC2 150774106 0.072 0.057 0.059 0.032 0.014 Table 10
Minor Allele Frequency based on population
Figure imgf000085_0001
Locus
.012 .014 .060 chrC2_156491175 0.381 0.408 0.307 0.672 0.662 .667 .313 .565 chrC2_187325 0.105 0.195 0.289 0.168 0.216 .21 1 .383 .185 chrC2_262401 0.188 0.283 0.277 0.122 0.153 .280 .591 .283 chrC2_5215469 0.241 0.342 0.250 0.728 0.500 .313 .838 .628 chrD1_101321498 0.441 0.279 0.281 0.258 0.432 .134 .061 .186 chrD1_104941557 0.144 0.197 0.147 0.136 0.243 .052 .014 .084 chrD1_105498119 0.182 0.094 0.180 0.040 0.081 .177 .042 .046 chrD1_10789012 0.322 0.362 0.230 0.401 0.149 .149 .368 .524 chrD1_11484008 0.068 0.073 0.044 0.178 0.189 .247 .081 .471 chrD1_117527468 0.040 0.01 1 0.004 0.003 0.000 .000 .000 .010 chrD1_125811329 0.308 0.151 0.206 0.096 0.324 .169 .518 .172 chrD1_126256993 0.233 0.228 0.188 0.144 0.378 .221 .819 .361 chrD1_126847301 0.100 0.137 0.218 0.010 0.054 .052 .043 .01 1 chrD1_15984279 0.245 0.278 0.265 0.050 0.014 .100 .368 .124 chrD1_16242433 0.336 0.256 0.273 0.139 0.143 .198 .517 .340 chrD1_18390852 0.223 0.171 0.1 1 1 0.006 0.108 .080 .000 .066 chrD1_18570323 0.401 0.409 0.561 0.243 0.527 .430 .379 .450 chrD1_66177762 0.161 0.1 12 0.104 0.010 0.097 .052 .014 .095 chrD2_1020904 0.580 0.563 0.31 1 0.369 0.297 .333 .671 .525 chrD2_105772916 0.192 0.272 0.372 0.284 0.338 .412 .426 .154 chrD2_1752007 0.135 0.056 0.043 0.133 0.041 .147 .250 .135 chrD2_56777338 0.000 0.000 0.000 0.000 0.000 .000 .000 .000 chrD2_717969 0.402 0.252 0.542 0.256 0.136 .432 .719 .195 chrD2_74293444 0.208 0.151 0.155 0.122 0.189 .134 .1 18 .430 chrD2_91989307 0.133 0.041 0.065 0.013 0.041 .029 .014 .025 chrD3 103840114 0.022 0.040 0.043 0.039 0.135 Table 10
Minor Allele Frequency based on population
Locus
Figure imgf000086_0001
.046 .000 .01 1 chrD3_122502120 0.176 0.236 0.243 0.313 0.392 .310 .313 .194 chrD3_1810839 0.603 0.528 0.427 0.065 0.129 .21 1 .143 .104 chrD3_24565823 0.151 0.024 0.030 0.003 0.000 .023 .028 .035 chrD3_24823793 0.073 0.184 0.186 0.197 0.541 .339 .250 .368 chrD3_28838660 0.022 0.01 1 0.009 0.000 0.041 .100 .343 .127 chrD4_41078218 0.458 0.491 0.482 0.493 0.919 .402 .212 .313 chrD4_42000379 0.077 0.134 0.106 0.038 0.014 .078 .015 .01 1 chrD4_63622083 0.241 0.082 0.065 0.069 0.083 .135 .061 .088 chrE1_130875919 0.271 0.103 0.303 0.013 0.000 .061 .061 .032 chrE1_131587399 0.141 0.047 0.022 0.013 0.000 .023 .056 .083 chrE1_3912105 0.199 0.076 0.097 0.123 0.405 .092 .074 .120 chrE1_4114158 0.438 0.461 0.415 0.507 0.365 .458 .439 .550 chrE1_48228153 0.205 0.196 0.147 0.145 0.176 .198 .530 .223 chrE1_48700963 0.096 0.060 0.048 0.000 0.027 .034 .000 .053 chrE1_5453028 0.522 0.376 0.435 0.21 1 0.284 .157 .029 .071 chrE2_22632289 0.373 0.389 0.421 0.374 0.608 .371 .724 .656 chrE2_34027888 0.059 0.022 0.089 0.000 0.000 .076 .014 .063 chrE2_35914023 0.275 0.241 0.152 0.050 0.292 .194 .181 .431 chrE2_36986631 0.410 0.603 0.618 0.392 0.257 .471 .281 .191 chrE2_38860686 0.297 0.049 0.039 0.090 0.081 .059 .015 .094 chrE2_39211557 0.440 0.422 0.495 0.41 1 0.324 .402 .407 .357 chrE2_65436639 0.227 0.298 0.283 0.330 0.189 .310 .147 .216 chrE2_7950477 0.543 0.503 0.583 0.434 0.403 .421 .323 .496 chrE2_8422942 0.078 0.064 0.066 0.320 0.054 .017 .028 .053 chrE3_36044809 0.237 0.41 1 0.548 0.530 0.243 .282 .191 .686 chrE3 55434272 0.385 0.383 0.421 0.039 0.324 Table 10
Minor Allele Frequency based on population
Figure imgf000087_0001
Locus
.317 .303 .538 chrE3_ .67006512 0. E1urope29 0.123 0.109 0.083 0.045 .032 .030 .077 chrF1_ .20309325 0.075 0.081 0.022 0.076 0.097 .034 .069 .050 chrF1_ .21799641 0.331 0.07 Mditeerranean9 0.113 0.048 0.108 .098 .042 .108 chrF1_ .26100599 0.356 0.194 0.068 0.072 0.189 .167 .186 .170
Etgyp
chrF1_ .27124984 0.206 0.253 0.297 0.373 0.292 .429 .667 .461 chrF1_ .38051725 0.541 0.644 0.671 0.317 0.122 .305 .530 .434
I/Iraqran
chrF1_ .565223 0.537 0.562 0.575 0.537 0.392 .464 .529 .399 chrF1_ .82068276 0.187 0.065 0.059 0.007 0.015 .250 .379 .289
Abi Sraanea
chrF1_ .82716202 0.288 0.191 0.125 0.339 0.243 .100 .100 .124 chrF1_ .91517402 0.214 0.223 0.184 0.176 0.351 .327 .044 .064
Idina
chrF2_ .26886470 0.104 0.153 0.104 0.459 0.405 .494 .591 .390 chrF2_ .38395360 0.349 0.270 0.279 0.334 0.338 .360 .029 .184
Sh Aitousa
chrF2_ .46855978 0.332 0.280 0.309 0.229 0.392 .407 .444 .310 chrF2_ .68572596 0.211 0.270 0.318 0.302 0.500 .323 .717 .3 E Aitassa13 chrF2_ .74863327 0.181 0.278 0.282 0.171 0.122 .306 .338 .336 chrF2_ .78303221 0.522 0.469 0.530 0.257 0.284 .571 .727 .595 chrF2_ .79632602 0.025 0.011 0.004 0.062 0.000 .006 .000 .007 chrF2_ .8427817 0.390 0.408 0.387 0.227 0.257 .378 .350 .489
[0145] Principal coordinates analyses (PCA) (Figure 5) broadly correlated with the
STRUCTURE analyses. PCA consistently grouped individuals from the same geographic cluster together as delineated by Bayesian clustering (Figure 3). Differences of SNP (Figure 5A) versus STR (Figure 5B) based analyses are most notably in the distance of the Arabian Sea populations from those of the Iraqi/Iranian populations (more distant with SNPs and less so with STRs). Also, SNPs position the South Asian populations close to that of the Indian populations as opposed to closer to the East Asian populations when STRs are used. Despite these slight changes in comparative distance, both PCA analyses show genetic distances to be correlated with that of geographical or physical distances of the populations and sampling sites.
[0146] The SNP (Figure 6A) and STR-based (Figure 6B) Neighbor-joining phylogenetic trees were also broadly concordant with the STRUCTURE and PCA defined lineages through forming groups along geographical lines. Very high bootstrap values are noted between cats that show strong associations in the other analyses, including, cats from Vietnam and Thailand, cats from the Kenyan Islands, Lamu and Pate, and Dubai, and those from various cities of Japan. However, at a fine-scale, minor discrepancies are observed. For example, mainland Kenyan cats, when analyzed with STRs, are in the middle of the European branch with a bootstrap value of 100%, but in the SNP -based tree, mainland Kenyan individuals are in between the European/Mediterranean and the Iraq/Iran/ Asian clades with a lower bootstrap of 43%. Additionally, the northwestern populations in India weakly grouped with either the Iraq/Iran clade or the Indian depending upon the marker.
[0147] The wildcat outgroups also showed significant differences between markers.
With SNPs, Felis s. libyca is more closely associated with the Mediterranean cats, while F. s. silvestris associated with the European cats. With STRs, the two wildcat groups form their own clade, in between the Mediterranean/European/ Iraqi/Irani populations and more eastern populations.
Discussion
[0148] Cultural histories, archeological evidence, and more recently, genetic investigations all support the theory of at least one cat domestication event in the 450,000 km2 region of the Fertile Crescent. The Fertile Crescent spreads from the land between the Tigris and Euphrates Rivers (currently Iraq), extending into modern Syria and Turkey, along the Mediterranean coast of Israel (the Levant region) and into the fertile regions of the Nile River Valley in Egypt. As agriculture and civilization spread, the provision of vermin population control to surrounding refuse piles and grain stores was an important benefit of the symbiotic relationship between the regional wildcats and humans. Bold wildcats may have repeatedly approached humans as the sedentary agricultural lifestyle proliferated throughout the Fertile Crescent. Over time, some cats may have moved with mobile tribes over short distances. Both natural and human-induced barriers have posed limits to feline migrations over the past 10,000 years, as well as varying human migrations due to stochastic political barriers. But as humans became increasingly mobile, so too have the cats, by hitching rides around the world on ships and colonizing new regions with limited founders. DNA sampling and genetic evaluations of modern cats provide only a present- day snapshot of cat population stratifications around the world. However, large DNA sample sets of cats from diverse geographical regions combined with an assortment of genetic markers with a variety of resolution powers can help define these cat populations, tracing recent migrations, and clarifying those more ancient relationships of the cats around the world.
[0149] This study focused on cat populations within the Fertile Crescent, Egypt, and eastern regions, examining the effect of different genetic markers on refining the site of cat domestication and clarifying the paths of migration. STRUCTURE analysis of SNPs and STRs genetically refined the cat population stratifications of the world, especially with the addition of cats from the Middle East and Asia. The previous STR study by Lipinski et al. (2008) suggests that worldwide cats divide into 4 basal lineages; Western European, Mediterranean basin, East African (Lamu and Pate), and Asian. By doubling the sample set and including 148 random SNP markers, the previous population demarcations were reinforced and an additional lineage in Iraq/Iran was detected. The previously defined African lineage, cats from the Kenyan islands of Lamu and Pate, appears to be rather a lineage that defines cats of Indian Ocean/ Arabian Sea including cats from Dubai, India and Sri Lanka, Thailand, and Vietnam. The SNPs more clearly defined this lineage than the STRs.
[0150] Additional stratifications can be resolved, dividing cats into seven modern populations for each marker type, eight overall populations considering a combined analysis. These population divisions align mostly along geographic regions, specifically Europe (including the Americas), East Mediterranean Basin (Turkey, Cyprus, Lebanon, and Israel), Egypt, Iraq/Iran, Arabian Sea, India (including Sri Lanka), Southern Asia (Thailand and Vietnam), and Eastern Asia (Taiwan, Japan, China, and South Korea). Both marker types support Egyptian cats as distinctive, perhaps a result of ancient breeding practices causing drift or strong isolation due to cultural and geographical barriers in the region. SNPs and STRs were discordant with the distinction of the cats from India and Sri Lanka. With SNPs, the Indian cats group with cats around the Arabian Sea, but with STRs, these same cats cluster with a distinctive Southern Asian group. The slower mutation rate of SNPs should strengthen their resolving power in the older cat populations; STRs should illuminate the more recent migrations that may not be visible with SNPs. Perhaps the differences in the SNP versus STR demarcations suggest that historically the India cats arrived from the West, whereas more recent migrations have come from the East.
[0151] In support of recent cat movements, approximately 66% of migrants appear to have originated from geographically close neighbors. However, the cat migrants in Taiwan and Japan are most likely due to human-mediated movement subsequent to human colonization or migration by European people. For example, 9.5% of the Japanese cats and 24.1% of Taiwanese cats appear to have a significant portion of European ancestry. The Nairobi Kenyan cats appear to be highly correlated with that of Europe, consistent with the European colonization of Kenya, which is readily depicted by the STR neighbor-joining phylogenetic analysis. A similar result was indicated in the previous study with cats from Tunisia, which appeared to also have European origins (Lipinski et al., 2008). An individual example is a cat sample that was collected in Luxor, Egypt, a city deep within the Nile Valley. This longhaired cat belonged to a woman who had recently moved from the coastal Mediterranean city of Alexandria. Her cat clearly owes most of its ancestry to that of European cats. While signs of historical colonization by western countries can be detected, Iraq's short history of British rule resulted in very little influence of the European cats in the feral populations of Iraq and Iran. Overall, the stratification of cats from these analyses is sufficient to define regional origins of modern cats, and recent migrations can be tracked by the cat's genetic constitution.
[0152] PCA analyses depicted a great divide between the regions of Europe, East
Mediterranean Basin, and Egypt versus cats from Southern Asian, and Eastern Asian populations, suggesting these larger regional groupings as the most genetically distinct. The phylogenetic relationships presented in the neighbor-joining trees also relay a significant difference between Eastern and Western domestic cats. Both approaches place the
Irani/Iraqi and Arabian Sea groups somewhat in between the Eastern - Western divisions. The wildcat species group with the Western European clusters of cats, leaving speculation as to whether the significant divide between western and eastern cats is due to more than one domestication event, or the ancient diaspora of early cat domesticates, followed by a decrease of migration and isolationism.
[0153] Population statistics assist the identification of the older cat populations and lineages, indicating that Egypt and the Mediterranean lineage have the lowest inbreeding and highest heterozygosity based on STRs, as well as the highest averages for effective number of alleles of the populations included in this study. FIS calculations based on SNPs show the Asuit, Egypt and Iraqi/Irani lineage to have the least amount in inbreeding but likely not statistically significant from other Egyptian and Mediterranean areas.
Additionally the Assuit collection was partially made up of cats that had been presented to the Veterinary School of Assuit University, and may likely represent cats from a variety of origins. Thus, the oldest cat lineages are represented in the Near East, primarily the Eastern Mediterranean countries and Egypt, supporting sites of cat domestication. The isolation of the cat populations in Iraq and Iran has undoubtedly prevented admixture, despite this, the population has not suffered from inbreeding. Cats from India, including Sri Lanka, show significant admixture with representation from all groups. Bootstrap values are low for the Indian cats, while STRUCTURE analysis indicated gene flow from surrounding areas, suggesting the Indian peninsula as a potential mixing pot for domestic cats. Overall, the regions of highest diversity focus around the location of the first human agricultural settlements, including Egypt, Israel, Lebanon, and Iraq.
[0154] Together, the various SNP and STR data of this study indicate that cats were first domesticated in the Fertile Crescent and Levant regions, potentially near Lebanon and Iraq. The Iraq/Iran clade is clearly delineated early in the Baysean clustering analysis as one of the first lineages, show little sign of admixture with the other lineages, and maintains a high diversity even when compared to the modern populations. Iraq has also had the benefit of relatively few influences from Europe; the modern populations found there are most likely to represent some of the first domesticated cats. The high diversity of other populations is a result of large numbers of migrations and introgressions from other regions of the world (such as northwestern India and northern Egypt). From the northern Fertile Crescent, domesticated cats have spread throughout the world, first out towards Iraq, the Eastern Mediterranean and then down through Egypt before extending to Asia and Europe. Since then, as Europeans traveled throughout the world, they brought with them their fellow felines, which have subsequently left their genetic pawprints in areas such as Kenya, Taiwan, Japan, and the Americas.
Example 2
Assessment of Genetic Assignment of Domestic Cats to Breeds and Worldwide
Random Bred Populations
[0155] In this example, 477 cats representing 29 fancy breeds were analyzed with
38 microsatellites (STRs), 148 intergenic SNPs, and 5 causative and linked phenotypic SNPs. Results of this study suggest that contrary to previous studies, the frequentist methods of Paekau (accuracy SNPs = 0.78, STRs = 0.88) surpass the Bayesian methods of Rannala and Mountain (SNPs = 0.56, STRs = 0.83). Additionally, a post-assignment verification step with the phenotypic SNPs will accurately identify between 0.31 and 0.58 of the mis-assigned individuals.
Materials and Methods:
[0156] Sample Collection. Twenty-nine breeds were represented by 477 cats. This study included 354 cats from the work of Lipinski et al. ((2008) Genomics 91 : 12-21) that analyzed 22 breeds. The 123 additionally collected samples represented seven additional breeds (Scottish Fold, Cornish Rex, Ragdoll, Manx, Bengal, Ocicat, and Australian Mist). All cats were representatives of their breed as found within the USA, except for a few Turkish Angora and Turkish Vans from an international collaboration. All cats were pedigreed and verified to be unrelated to the grandparent level. Worldwide random bred data (N=944) was included from results discussed in Example 1 in order to assess the origins of each of the breed populations. New samples were collected via a buccal (cheek) swab and extracted following the manufacturer's protocol (Qiagen).
Table 11
Origins of cat Breeds*
Indicative Phenotypic Traits
Origins Based on Historical
Breed Inclusion Exclusion Evidence1
Persian LH SH British RB, Siamese, Maine Coon
Persian, American SH, Abyssinian,
Exotic SH SH LH Burmese
British SH SH LH British RB, Persian
Scottish Scottish RB, British SH, American SH,
Fold Ear Fold Persian, Exotic SH
Chartreux Blue French RB, Persian, British SH
American British RB, American RB, Persian,
SH SH LH Burmese
Sphynx Hairless American RB
Japanese
Bobtail Bobtail Japanese RB
Cornish
Rex Cornish curl British RB, Siamese
Ragdoll LH American RB, Birman
Maine Coon LH American RB
Abyssinian SH, Ticked, Agouti LH British RB, Egyptian RB, African RB
Siberian LH Russian RB2
Norwegian
FC LH Norwegian RB
Manx Tailless, SH LH British RB Table 11
Origins of cat Breeds*
Indicative Phenotypic Traits
Origins Based on Historical
Breed Inclusion Exclusion Evidence1
Egyptian
Mau Egyptian RB
Turkish
Angora Turkish RB
Turkish
Van Turkish RB
Bengal Asian leopard cat, American RB
Sokoke Kenyan randombred3
Ocicat Spotted, SH LH Abyssinian, Siamese
Russian
Blue Blue, SH British RB, Siamese
Australian
Mist Burmese, Abyssinian, Australian RB4
Non-Agouti, Burmese RB, Siamese, European RB,
Burmese Agouti, Sepia Silver British SH
Non-Agouti,
Singapura Agouti Silver Singaporean RB, Abyssinian
Birman LH, Points Burmese RB, various breed outcrosses
Korat Blue, Non-agouti Thai RB
Havana Chocolate, Non-
Brown Agouti Points Siamese, British SH, Russian Blue
SH, Siamese Points,
Siamese Non-Agouti Thai RB
RB = randombred, SH = shorthair, LH = Long hair. Unless noted origins are according to: 'Gebhardt, 1991(Gebhardt (1991). The Complete Cat Book. Howell Book House, New York, 2The Royal Canin Cat Encyclopedia, 2000, Groupe Royan Canin, Paris, France, 3The International Cat Association (on the internet at tica.org), or 4Australian Mist Breed Council (on the internet at australianmist. info/Home .html).
[0157] Thirty eight micro satellites were genotyped in the 123 newly acquired cats following the PCR and analysis procedures of Lipinski et al. (2008), supra. The 148 intergenic SNPs were assayed in all 477 breed cats for this study as described in Example 1. Five additional phenotypic SNPs were also evaluated in all cats. The phenotypic SNPs consisted of a causative mutation for the most common form of long hair in cats (FGF5 A475C) (Kehler et al. (2007) J Hered 98, 555-66.), Burmese and Siamese color points (TYR G715T and G940A, respectively) (Lyons et al. (2005) Animal Genetics, 36, 1 19- 126), and the mutations for the color variants chocolate and cinnamon
(Phen_TYRPl_5IVS6 and C298T) (Lyons et al. (2005) Mammalian Genome, 16, 356- 366). Golden Gate Assay amplification and BeadXpress reads were performed per the manufacturer's protocol (Illumina Inc., San Diego) on 50-500ng of DNA, using the same oligo primer pool as used in Example 1. Each run of the SNP assay contained both an internal positive and negative control in order to validate repeatability and contamination. [0158] Population Statistics. Hardy- Weinberg Equilibrium (HWE) with associated chi squared tests was performed by population, as well as observed and expected
heterozygosites with GenAlEx v.6.3 (Peakall & Smouse 2006, supra). FIS and FST were calculated with Fstat v. 2.9.3.2 (Goudet 1995, supra). F-statistics were calculated both by sampling location, and based on the populations as assigned by STRUCTURE, regardless of sampling location. Reynold's genetic distance was calculated between all pairs of breeds due to the predicted recent separation of these populations (Reynolds et al. 1983, supra).
Population Structuring
[0159] Bayesian Clustering. Data sets were analyzed with the Bayesian clustering program STRUCTURE (Pritchard et al. 2000) under the admixture model with correlated allele frequencies and a burn-in of 100,000 with 100,000 additional iterations. Values of K were calculated from K = l to K = 33, each run was replicated 10 times. Posterior log likelihoods were used in the calculation of ΔΚ to best estimate the number of ancestral populations through the program Harvester (Evanno et al. 2005, supra). All ten iterations were then combined through the program CLUMP (Jakobsson & Rosenberg 2007, supra) to create a consensus clustering. To assess the effects of varying marker types on the final results, STRUCTURE analysis was conducted on the data with the two different
permutations: SNPs and STRs.
[0160] Principal Coordinate Analysis . Principal components analyses were conducted through the calculation of Nei's genetic distance using the software GenAlEx v.6.3 (Peakall & Smouse 2006, supra). For the PCA plots, both the data in the present example and data from the worldwide random bred populations discussed in Example 1 were considered to show the relationship of the cat breeds and their random bred population origins.
[0161] Breed Lineage Assignment. Cat breed populations were assigned to the eight ancestral lineages of random bred worldwide populations of cats (Europe, Mediterranean, Egypt, Iraq/Iran, Arabian Sea, India, Southeast Asia, and East Asia) identified in Example 1 by calculating -log(Likelihood) values using the Bayesian population assignment methods available in the software Geneclass2 (Piry et al. 2004, supra).
[0162] Assignment Testing. Ten sets of 50 individuals were randomly selected from the sample set and assigned to a population of origin using the remaining samples as the reference populations. The Bayesian method of Rannala and Mountain (1997), supra, and the Frequentist method suggested by Paetkau et al. (2004), supra, were compared as they performed best in the previous assignment study of Negrini et al. (2009) Animal Genetics, 40: 18-26) when compared to the Pritchard et al. (2000) Genetics, 155:945-959) and the Baudoulin & Lebrun methods (2001) Proc. Int. Symp. on Molecular Markers, pp. 81-94. Additionally, the assignment tests were performed in three iterations: intergenic SNPs, intergenic and phenotypic SNPs combined, and STRs. Tallies of type I error (an individual not reassigning to its population of origin) and type II error (an individual not from that population assigning to it) were used to calculate the sensitivity and specificity of the assignment method (Negrini et al. 2009, supra).
[0163] Phenotypic SNPs were also used post-assignment test to compare both STRs with and without phenotypic SNP input, as well as comparing the use of phenotypic SNPs combined with intergenic SNPs for the assignment test as opposed to only post assignment testing. Cats were considered mis-assigned if they had genotypes exclusionary for the breed. For example, an individual assigned to the Exotic short haired group was identified as mis-assigned if it was homozygous for long-hair.
Results:
[0164] Summary Statistics. Pedigreed cats (N = 477), representing 29 recognized breeds were included in this study (Table 12). The number of cats per breed ranged from 7 to 25 with an average of 16.4 individuals per breed. STRs had a call rate of 88.2% and SNPs had a 94.0% average call rate. While the chi-squared goodness-of-fit test indicated that 126 of the 148 SNPs and 36 of the 38 STRs were not in HW equilibrium in at least one breed group, only one SNP marker (chrF2_46855978) was found to be not in HW equilibrium in more than 50% of the breeds (Table 13). Twenty-seven breeds have 10-25 SNPs not in HWE; however the Russian Blue and Turkish Van breeds have 31 and 33 of the total 186 genetic markers out of HWE. This is suggestive of potential population substructuring or recent inbreeding. The frequency of the genotypes and alleles for the phenotypic SNPs were calculated by counting (Table 14). The FGF5 A475C mutation causing long coated cats in the homozygous state was by far the most prevalent of the phenotypic SNPs as it was found in all but eight of the breeds. In contrast, cinnamon, caused by TYRPl C298T, was only seen in five breeds two of which had a frequency lower than 0.1. Table 12
Population statistics of cat breeds.
Total Total PA PA Na Na Ho Ho Fis Fis(
Alleles Allele
Breed N S
Persian 15 276 181 1 0 1.865 4.763 0.285 0.502 -0.023 0.145
Exotic SH 19 279 178 1 1 1.885 4.684 0.253 0.526 0.073 0.068
British SH 18 276 192 2 0 1.865 5.053 0.242 0.546 0.101 0.064
Scottish Fold 17 269 180 2 1 1.818 4.737 0.261 0.574 0.001 0.047
Chartreux 13 264 151 0 0 1.784 3.974 0.237 0.557 0.1 0.042
American SH 13 269 168 0 0 1.818 4.421 0.281 0.552 -0.023 0.035
Sphynx 17 277 178 2 0 1.872 4.684 0.271 0.549 0.047 0.05
Japanese Bob. 19 267 191 4 0 1.804 5.026 0.223 0.578 0.146 0.076
Cornish Rex 15 262 163 2 0 1.77 4.289 0.238 0.555 0.049 0.026
Ragdoll 15 265 178 4 0 1.791 4.684 0.29 0.624 -0.057 0.001
Maine Coon 19 282 210 2 1 1.905 5.526 0.256 0.602 0.114 0.043
Abyssinian 15 277 130 1 1 1.872 3.421 0.287 0.415 0.022 0.11
Siberian 17 275 227 4 2 1.858 5.974 0.26 0.705 0.093 -0.06
Norwegian FC 16 284 248 8 0 1.919 6.447 0.28 0.667 0.063 0.023
Manx 17 282 233 6 2 1.905 6.132 0.304 0.696 -0.002 -0.018
Egyptian Mau 14 268 160 1 0 1.811 4.211 0.246 0.495 0.029 0.114
Turkish Angora 21 284 275 10 1 1.919 7.237 0.251 0.674 0.109 0.055
Turkish Van 20 277 259 6 0 1.872 6.816 0.236 0.595 0.12 0.123
Bengal 18 274 192 10 2 1.851 5.053 0.244 0.579 0.065 0.038
Sokoke 7 222 92 0 0 1.5 2.421 0.166 0.368 0.003 0.004
Ocicat 10 264 142 3 2 1.784 3.737 0.236 0.495 0.035 0.048
Russian Blue 17 259 146 2 1 1.75 3.842 0.185 0.453 0.16 0.063
Australian Mist 15 273 156 4 0 1.845 4.105 0.268 0.569 -0.01 -0.045
Burmese 19 262 158 2 1 1.77 4.158 0.196 0.423 0.08 0.158
Birman 20 247 133 3 0 1.669 3.5 0.169 0.437 0.134 0.027
Havana Brown 14 245 113 1 0 1.655 2.974 0.168 0.423 0.115 -0.015
Korat 25 246 150 2 0 1.662 3.947 0.168 0.516 0.077 0.032
Siamese 15 242 133 2 1 1.635 3.5 0.2 0.466 0.002 0.024
Singapura 17 232 94 1 0 1.568 2.474 0.182 0.342 0.055 0.019
Total 477 296 490 1.794 4.544 0.237 0.534 0.058 0.044
N implies number of samples, PAB implies private alleles between breeds, PAW implies private alleles between breeds and worldwide randombred populations, Na implies average effective number of alleles, Ho implies observed heterozygosity, FIS implies inbreeding coefficient
o o o o o o o ο o o o o o o o o o o o O o o o O
- > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ > - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \ - > \
^
—^
—^ to
to —^
to
to
to —^
—^ to ^ to —^ to to — to to —^
■ε- to —^
to —^ —^
Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn Cn 3ersian
cn cn cn cn cn cn cn cn cn Exotic SH
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3ritish SH
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Scottish Fold cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Chartreux
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn American SH
Figure imgf000097_0001
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Sphynx
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Japanese BobtailiJ cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Cornish Rex cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn agdoll
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlaine Coon cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Abyssinian
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Siberian
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Norwegian FC cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlanx
Figure imgf000097_0002
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Egyptian Mau
cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Angora cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Van cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3engal
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Sokoke
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Dcicat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Russian Blue cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Australian Mist cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3urmese
cn cn cn cn cn 3irman
cn cn cn cn cn cn cn cn cn cn cn cn cn Havana Brown cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Korat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Siamese
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Bingapura ho o -t^ o cn o co co cn
Total
T0T8£0/ZT0ZSil/I3d ZLL SIIZIOZ OAV o o o o O o O o o o o o o o o o o o o o o o o o
3" 3" 3" 3" 3" 3" 3" 3" 3- 3" 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 3" 3- ro roo c roo c roo c roo c roo roro roro roro roro roro ro ro ro ro ro ro ro ro -% % -% -% -%
co c c > - o c >o c >o c >o c >o
cn cn co cn co co cn ro -j co
co cn co co ro cn co cn
co ro cn cn cn co -j ro cn ro cn -j ro
cn cn co cn -j cn cn ro cn cn co ro
co cn co cn co cn co cn cn cn -j -J co cn
co ro co co ro co cn cn cn co ro -J cn co
cn co cn co co co cn -j -J -j cn cn co co co ro cn
ro cn cn co ro cn co co ro cn
cn ro ro co
H
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3ersian
Exotic SH cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3ritish SH
Scottish Fold Chartreux cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn American SH
Figure imgf000098_0001
Sphynx
© Japanese Bobtail)
« Si Cornish Rex a agdoll cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlaine Coon S" σ* cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Abyssinian "t
CTQ
cn cn cn cn Siberian »Q
S
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Norwegian FC cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlanx G
3 cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Egyptian Mau
o cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Angora Si cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Van cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3engal a cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Sokoke
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Dcicat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Russian Blue
Australian Mist 3urmese
3irman
Havana Brown
Korat
Siamese cn cn cn cn cn cn Singapura co ho ho ho o ho
Figure imgf000098_0002
ho — >■ ho ho ho ho
Total
T0l8C0/Zl0ZSil/13d o o o o o o o o o o o o o o o o o o o o o O o o
3- 3" 3- 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3- 3"
o o o o o o o o o ro -^. ro -^. ro ro -^. ro -^. ro ro ro ro -^. ro ro -^. ro -^. ro ro -^. c roo
r ro ro ro λ λ λ -^. co ro ro ro -j
co to co ro — λ -j CD CD cn CD cn CD -j
to -j cn cn CD co cn cn co to cn CD CD co to cn co ro cn CD
co CD co cn co co co co to -J cn ro cn CD cn -J to
ro co cn CD cn cn cn co to co CD co — λ -^. co CD co to CD cn CD
CD ro ro ro ro cn cn — λ ro cn co co ro cn cn co cn co cn CD
cn co cn cn to -J ro -J CD -j -^. to co to to co -^. CD cn -J
n cn co -J co cn to co ro to co -^. cn co CD to to
cn co cn co cn cn co co -^.
CO C3 0 0 CO C C CO C3 C3 0 CO C C CO co co co co co co co co 3ersian
CO C3 C3 0 0 CO CO C C CO CO ϊ CO CO co co co co co co co co Exotic SH
co co co co co co co co co co co co co co co co 3ritish SH
co co co co co co co co co co co co co co co co co co co co co co co Scottish Fold co co co co co co co co co co co co co co co co co co co co co co co co Chartreux
co co co co co co co co co co co co co American SH
Figure imgf000099_0001
co co co co co co co co co co co co co co co co co co co co co Sphynx
co co co co co co co co co co co co co co co co co co co co co Japanese Bobtail|
co co co co co co co co co co co co co co co Cornish Rex co co co co co co co co co co co co co co co co co agdoll
co co co co co co co co co co co Vlaine Coon co co co co co co co co co co co co co co co co co co co co co co co Abyssinian
co co co co co co co co co co co co co co co co co Siberian
co co co co co co co co co co co co co co co co co co co Norwegian FC co co co co co co co co co co co co co co co co co co co Vlanx
Figure imgf000099_0002
co co co co co co co co co co co Egyptian Mau
Turkish Angora co co co co co co co co co co co co co Turkish Van
co co co co co co co co co co co co co 3engal
co co co co co co co co co co co co co co co co Sokoke
co co co co co co co co co co co co co Dcicat
co co co co co co co co co co co co co co co Russian Blue
co co co co co co co co co co co co co co co Australian Mist
3urmese
3irman
Havana Brown co co co co co co co co co co co co co co co co co Korat
co co co co co co co co co co co co co co co co co Siamese
Bingapura
Figure imgf000099_0003
Total
T0T8£0/ZT0ZSil/I3d ZZ,Z,8£I/ZI0Z OAV o
3- σ
σ>
—^
-j
-j
σ>
r
h
Figure imgf000100_0001
T0l8C0/Zl0ZSil/X3d ZLLHSIIZIOZ OAV
Figure imgf000101_0001
H
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3ersian
Exotic SH
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3ritish SH
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Scottish Fold cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Chartreux
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn American SH
Figure imgf000101_0002
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Sphynx
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Japanese Bobtail) cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Cornish Rex cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn agdoll
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlaine Coon cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Abyssinian
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Siberian
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Norwegian FC cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Vlanx
Figure imgf000101_0003
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Egyptian Mau r o cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Angora Si r cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Turkish Van cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn 3engal a cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Sokoke
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Dcicat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Russian Blue cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Australian Mist cn cn cn cn cn cn cn cn cn cn cn cn 3urmese
cn cn cn 3irman cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Havana Brown
cn cn cn cn cn cn cn Korat
cn cn cn cn cn cn cn cn cn cn cn cn cn Siamese
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Singapura
ho O ho ho ho o cn cn ->■ o cn cn ->■ ho
Total
T0l8£0/Zl0ZSil/I3d £./.8£l/£'l0£' OAV o o o o O o o o o o o o o o o o o o O o o o o o
3- 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3" 3"
ro ro ro ro
σ> -^. co ro to co co cn co ro ro ro ro cn cn co co cn co co co co co
co σ> co cn —^ ro ro cn co cn —^ CD -J cn cn -^. to cn to co cn cn -^.
n co co co cn CD cn CD —^ —^ co CD -^. CD ro cn ro co to to CD
-j cn to co —^ —^ cn ro cn ro CD to CD CD co ro CD co ^ cn co ^ ro
ro cn cn cn -J cn co ro —^ -^. CD to to cn -^. to cn ^ CD cn -j
cn to co -^. ro ro co to cn cn co cn ro CO ■ε- cn cn cn cn CD co
to ~-l σ> -j CD CD -j ro co to -^. ro -j CD ro co cn co co ro co
cn co CD CD ro ro cn cn -^. to —^ cn ro ro to to -J cn co co
H
co co co co co co co co co co co 3ersian
co co co co co co co co co co co co co co co co co Exotic SH
cn cn cn cn cn cn cn cn cn cn cn cn 3ritish SH n co co co co co co co co co co co co co co co co co co co co co co Scottish Fold
»Q S
co co co co co co co co co cn cn cn cn cn cn cn cn cn cn cn cn Chartreux
3 E
cn cn cn cn cn cn co co co co c3 Eo co co co co cn cn cn cn American SH cn cn cn cn cn cn co co co co co co co co 3c Eo co co Sphynx
E2
co co co co co co co co cn cn cn cn cn cn cn cn cn Japanese Bobtail
E2
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn c E2n cn cn cn cn cn Cornish Rex
E2
cn cn cn cn cn cn cn cn cn cn co co co co co co co co agdoll
E2
cn cn cn cn cn cn cn cn cn cn cn cn co co co co co co co c E2o co co Vlaine Coon co co co co co co co co co co co co cn cn cn cn cn cn c E2n Abyssinian
E2
cn cn cn cn cn cn cn cn cn co co co co co co co co co co Siberian
co co co co co co co co co co co co co co co co co co co co co Norwegian FC cn cn cn cn co co co co co co co co co co co co co co co co co Vlanx
Figure imgf000102_0001
cn cn cn co co co co co co co co co co co co cn cn cn Egyptian Mau r o co co co co co co co co co co co co co co co co co co co co co Turkish Angora Si r cn cn cn cn co co co co co co co co co co co co cn cn cn cn Turkish Van co co co co co co co co co co co co co co co co co co co co co co 3engal a co co co co co co co co co co co co co co co co co co co cn cn cn cn Sokoke
co co co co co co co co co co co co co co co cn cn cn cn cn cn cn Dcicat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Russian Blue cn cn cn cn co co co co co co co co co co co co co co co co co Australian Mist co co co co co co co co co co co cn cn cn cn cn cn 3urmese
co co co co co co co co co co co cn cn cn 3irman
co co co co co co co co co co co co cn cn cn cn Havana Brown co co co co co co co co co co co co co cn cn cn cn cn cn Korat
cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn cn Siamese
Bingapura
Figure imgf000102_0002
Total
T0T8£0/ZT0ZSil/I3d £ ./.8£T/ZT0Z OAV o o o o
o O 3" 3" 3" 3"
> O > O > > O > O o O > O o o O O O O O O O O > o
CD CD C >D C >D CD C >D C >D C >D C >D C >D C >D C >D C >D C >D C >D CD C >D -n -n -n -n
r ro CD to to oo co -J -J cn cn co ro ro CD CD ro ro ro ro
σ> co cn -J cn CD co CD -J cn to co cn co cn cn co co cn co -j -j -j
ro to co
ro cn co co
-j co CD cn
co ro co co
cn ro co
CD ro ro
ro
3ersian
Exotic SH
3ritish SH
Scottish Fold Chartreux
American SH
Figure imgf000103_0001
Sphynx
Japanese Bobtail Cornish Rex agdoll
Vlaine Coon Abyssinian
Siberian
Norwegian FC Vlanx
Figure imgf000103_0002
Egyptian Mau Turkish Angora Turkish Van 3engal
Sokoke
Dcicat
Russian Blue Australian Mist 3urmese
3irman
Havana Brown
Korat
Siamese
Bingapura ho ho cn co ho ho ho co ho
Total
T0T8£0/ZT0ZSil/I3d ζζ,ζ,8£τ/ζτοζ OAV Table 13 - Chi-squared test for Hardy- Weinberg Equilibrium by cat breed
Figure imgf000104_0001
FCA132 ns ns ns ns • ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns • ns • ns ns • ns ns 4
FCA149 ns ns ns • • ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns ns • ns ns ns ns 4
FCA211 ns ns • ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns • ns ns 2
FCA220 ns ns ns ns ns ns ns • ns ns ns ns ns ns ns • ns ns ns • ns ns ns ns ns ns ns ns ns 3
FCA223 ns ns • ns ns ns ns ns ns ns ns • • ns ns • ns • ns • ns ns ns ns ns ns ns • ns 7
FCA224 ns ns ns ns ns ns ns ns ns ns • ns ns ns ns • ns • ns ns ns ns ns ns • ns ns ns ns 4
FCA229 ns • ns ns • ns ns ns ns • ns ns ns ns ns ns ns • ns ns ns ns • ns ns ns ns ns ns 5
FCA262 • ns ns ns ns ns ns ns ns • ns ns ns ns ns • ns • ns ns ns ns ns ns • ns • ns ns 6
FCA293 ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns 1
FCA305 ns ns ns ns ns ns • ns ns ns ns • ns • ns ns ns ns • ns ns ns ns ns ns ns ns ns ns 4
FCA310 ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0
FCA391 ns • • ns ns • • ns • ns • • • ns • ns • ns ns ns ns • ns ns ns ns ns ns ns 11
FCA441 ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns ns ns 1
FCA453 ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns ns ns ns 1
FCA628 ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns ns ns ns ns ns • ns ns • • ns 4
FCA649 ns ns ns • ns • ns ns ns ns • ns ns ns ns ns ns ns ns • ns ns ns ns ns ns • ns ns 5
FCA678 ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns • ns ns ns ns ns ns ns ns ns ns • 3
FCA698 • ns ns ns ns ns ns ns ns ns ns ns ns • ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 2
Total 14 21 17 11 18 21 20 25 13 11 23 17 20 16 15 25 25 31 14 14 10 33 12 17 23 16 18 13 16 ns = not significantly out of Hardy- Weinberg Equilibrium, · = significantly out of HWE with p-value < 0.05
14 - Phenotypic SNP Frequencies
Long Hair Burmese Points Siamese Points Chocolate Cinnamon
FGF5 A475C TYR G715T TYR G940A Phen_TYRP1_5IVS6 TYRP1 C298T
Freq. Freq.
Breed N AA AC CC C N GG GT TT T N GG GA AA A N CC CG GG Freq. N CC CT TT
Persian 15 0 1 14 0.97 15 15 0 0 0 15 5 4 6 0.53 15 12 2 1 0.13 15 15 0 0
Exotic SH 17 5 10 2 0.41 19 19 0 0 0 17 14 2 1 0.12 19 15 3 1 0.13 19 19 0 0
British SH 18 16 2 0 0.06 18 18 0 0 0 17 13 0 4 0.24 18 11 2 5 0.33 18 15 3 0
Scottish Fold 16 13 3 0 0.09 17 17 0 0 0 15 14 1 0 0.03 17 13 4 0 0.12 17 17 0 0
Chartreux 10 5 5 0 0.25 13 13 0 0 0 11 11 0 0 0 13 13 0 0 0 13 13 0 0
American SH 13 10 2 1 0.15 13 11 2 0 0.08 13 13 0 0 0 13 12 0 1 0.08 13 13 0 0
Sphynx 16 9 1 6 0.41 16 6 6 4 0.44 12 9 1 2 0.21 17 8 5 4 0.38 17 17 0 0
Japanese Bobl 14 8 2 4 0.36 18 18 0 0 0 15 13 2 0 0.07 19 19 0 0 0 19 19 0 0
Cornish Rex 15 14 1 0 0.03 15 15 0 0 0 14 3 4 1 0.21 14 13 1 0 0.04 15 15 0 0
Ragdoll 15 4 3 8 0.63 15 15 0 0 0 15 0 0 15 1 15 13 2 0 0.07 15 15 0 0
Maine Coon 14 0 0 14 1 18 18 0 0 0 17 17 0 0 0 19 16 2 1 0.11 19 19 0 0
Abyssinian 15 15 0 0 0 15 15 0 0 0 15 15 0 0 0 15 12 3 0 0.1 15 4 6 5
Siberian 14 1 3 10 0.82 16 16 0 0 0 15 8 6 1 0.27 17 16 1 0 0.03 17 17 0 0
Norwegian FC 13 8 3 2 0.27 16 16 0 0 0 15 15 0 0 0 16 15 0 1 0.06 16 16 0 0
Manx 15 8 6 1 0.27 17 17 0 0 0 16 16 0 0 0 17 16 1 0 0.03 17 17 0 0
Egyptian Mau 12 12 0 0 0 14 14 0 0 0 12 12 0 0 0 14 14 0 0 0 14 14 0 0
Turkish Angors 20 0 0 20 1 21 21 0 0 0 20 17 1 2 0.13 20 15 5 0 0.13 21 21 0 0
Turkish Van 18 0 0 18 1 19 19 0 0 0 20 19 1 0 0.03 19 14 2 3 0.21 20 20 0 0
Bengal 16 15 1 0 0.03 18 16 2 0 0.06 14 9 4 1 0.21 18 16 2 0 0.06 17 17 0 0
Sokoke 6 6 0 0 0 7 7 0 0 0 4 3 0 1 0.25 6 5 1 0 0.08 7 7 0 0
Ocicat 8 8 0 0 0 10 10 0 0 0 9 9 0 0 0 10 4 1 5 0.55 10 6 3 1
Russian Blue 15 14 0 1 0.07 17 16 1 0 0.03 15 11 3 1 0.17 17 17 0 0 0 17 17 0 0
Australian Mist 13 11 2 0 0.08 15 2 0 13 0.87 12 10 1 1 0.13 15 6 6 3 0.4 15 7 7 1
Burmese 19 19 0 0 0 19 0 1 18 0.97 16 16 0 0 0 19 9 4 6 0.42 19 18 0 1
Birman 19 0 0 19 1 20 20 0 0 0 16 0 0 16 1 20 12 5 3 0.28 20 20 0 0
Havana Brown 11 11 0 0 0 14 14 0 0 0 12 10 1 1 0.13 14 0 1 13 0.96 14 14 0 0
Korat 23 22 1 0 0.02 25 25 0 0 0 21 20 1 0 0.02 25 1 2 22 0.92 25 25 0 0
Siamese 15 15 0 0 0 15 15 0 0 0 13 0 0 13 1 15 2 6 7 0.67 15 15 0 0
Singapura 16 16 0 0 0 15 0 0 15 1 14 14 0 0 0 17 17 0 0 0 17 17 0 0
[0165] Genetic Diversity. The population genetic data is presented in Table 12. The average effective number of SNP alleles observed averaged 1.794 across breeds, ranging from 1.500 in Sokoke to 1.919 in Norwegian Forest and Turkish Angora. The average effective number of STR alleles observed averaged 4.54 across breeds, ranging from 2.42 in Sokoke to 7.23 in Turkish Angora. Private STR alleles within breeds ranged from 0 - 10, however, when the breeds were compared to worldwide random bred populations, private alleles within breeds dropped to between 0 - 2 per breed. No SNPs had private alleles in a breed.
[0166] The average SNP -based observed heterozygosity was 0.287, ranging from 0.166 in Sokoke to 0.304 in Manx. The average STR-based observed heterozygosity was 0.534, ranging from 0.342 in Singapura to 0.705 in Siberian. Inbreeding coefficients (FIS) were lowest in the Ragdoll (-0.057) and Siberian (-0.060) with SNPs and STRs,
respectively, and highest within the Australian Mist Cats (0.160) and Burmese (0.158). Between population variation FST values were 0.237 ± 0.007 with SNPs and 0.269 ± 0.019 with STRs.
[0167] Breed Clustering. The most likely value of K, the number of structured groupings, could not be decisively determined. A significant difference between the log likelihoods was not evident for either marker type between K = 17 - 33 (Figure 7), however, a plateau was suggested near K = 21 for STRs and K = 17 for SNPs (Figure 8). As a result, a combination of the ΔΚ plots and common sense directed selection of the most likely number of populations. For STRs, at K > 24 (Figure 9B), different lineages within specific breeds, such as Norwegian Forest Cat and Turkish Angora, became apparent before five other breed groups would split: Persian / Exotic SH, British SH / Scottish Fold, Australian Mist / Burmese, Birman / Korat, and Siamese / Havana Brown. Similar results were found for the SNPs-based analyses; however the associations of the Asian based breeds varied. SNPs appear to resolve the Birman and Singapura breeds from the other Asian breeds more readily. Considering both SNPs and STRs, Persians appear to have influenced several younger and older breeds: Exotic shorthair, Scottish Fold, British Shorthair and Chartreux. For breeds with Asian heritage, Siamese have a strong influence on the Havana Brown, Korats, Birmans, and Singapura (Figure 8).
[0168] The principal coordinate analyses indicate the relationship of the sub-groups of breeds and their likely closest random bred origins (Figure 10). The breeds that originated solely from European and American random bred cats cluster with the random bred populations of Europe and America. Likewise, breeds with Asian decent grouped with the South Asian populations of random bred cats, and the Sokoke shows a strong influence from its roots in Kenya. The breeds that do not share similar coordinates with a random bred population such as, Russian Blue, Ocicat, Singapura, Australian Mist and Birman, show a strong influence from both Europe and Asia.
[0169] Using Bayesian clustering, the breeds were then assigned back to the eight random bred lineages discussed in Example 1 (Table 15). Four regional areas have contributed to the development of cat breeds. Asian breeds, such as Birman, Burmese, Siamese and others grouped with Southern Asian cats, Western breeds, such as Persian, Norwegian Forest Cat, Maine Coon and others grouped with the Western European random bred cats. Turkish Angora and Turkish Van assigned to the Eastern Mediterranean cats and the Sokoke to the Arabian Sea region. Three breeds showed regional variation depending on the marker type used for assignment. When analyzed with data from SNPs and STRs, the Turkish Angora assigned to the Eastern Mediterranean or Europe, Bengal assigned to the Arabian Sea or Europe, and the Ocicat assigned to Europe or South Asia, respectively.
Table 15a Assignment of cat breeds to random bred cat populations using SNPs.
Breed SNPs (N=148)
Lineage "-log(L)"
South East
Europe East Med South Medraqlran Arabian India Asia Asia
Birman South Asia 562 .439 514, .619 489. 325 571 , .811 466 .884 398 .272 357 .638 494 .121
Burmese South Asia 537 .957 494, .594 510. 756 554 .652 452 .18 353 .1 232 .359 408 .667
H. Brown South Asia 498 .346 470, .353 477. ,771 538 .807 421 , .824 376 .835 266 .337 404 .7
Korat South Asia 783 .086 710, .194 728. 915 728 .005 569 .748 497 .518 241 , .988 544 .729
Siamese South Asia 521 .766 481 , .206 493 .075 520 .538 417, .91 356 .165 196 .049 363 .29
Singapura South Asia 610, .855 635 .495 634. ,003 697 .695 541 , .126 518 .324 402, .416 539 .635
Abyssinian Europe 425 .881 506, .972 520. , 173 739 .043 523 .387 571 , .166 539 .713 582 .183
Russian Blue South Asia 426 .363 443, .64 443, .657 549 .342 451 , .198 439 .924 406, .281 478 .247
American SH Europe 214, .445 294 .034 300. 891 436 .278 342 .32 356 .071 430, .155 363 .917
British SH Europe 266 .189 351 , .574 383. ,015 509 .425 386 .181 402 .229 499 .062 426 .489
Chartreux Europe 243 .214 287. 905 310. 595 392 .542 328 .31 306, .122 390 .676 340 .836
Japanese Bob. Europe 241 , .661 256 .018 267. 56 369 .44 306, .997 289 .681 354 .146 274 .931
Maine Coon Europe 233 .644 336 .954 359. ,517 507, .38 383 .73 400 .377 481 , .154 409 .93
Norwegian FC Europe 186 .918 268 .319 297. ,021 459 .99 364 .374 361 .486 460, .332 367 .953
Persian Europe 210, .224 280 .822 298. 776 425 .561 327 .435 320 .381 410, .002 328 .219
Exotic SH Europe 275 .475 367 .195 380 .41 532 .774 391 .854 408 .132 500, .594 423 .104
Sphynx Europe 229 .867 268 .333 294. 366 421 , .316 343 .479 304, .696 385 .86 333 .086
Siberian Europe 177, .505 205 .628 244. , 135 368 .507 282 .501 286 .135 350, .747 277 .186
Egyptian Mau Europe 278 .503 303, .627 303. 291 421 , .446 345 .331 349 .259 422 .453 366 .832
Sokoke W Indian 215 .491 213 .151 215 .151 222 .711 175, .088 194 .761 214, .181 212 .471 Table 15a Assignment of cat breeds to random bred cat populations using SNPs.
Breed SNPs (N=148)
Lineage "-log(L)"
South East
Europe East Med South Medraqlran Arabian India Asia Asia
Turkish Angora * Europe 206.309 215.369 239.522 346.148 308.088 297.611 395.989 324.211
Turksih Van East Med 251.489 233.29 268.56 383.923 339.409 320.684 396.447 367.681
Cornish Rex Europe 317.191 368.372 358.46 488.121 383.104 360.937 413.799 403.094
Manx Europe 183.172 266.261 293.483 465.86 343.149 354.55 469.19 382.31
Ragdoll Europe 238.285 277.549 295.736 393.95 342.598 302.199 364.068 309.321
Scottish Fold Europe 285.089 410.698 439.66 579.88 419.796 453.876 548.531 480.68
Australian Mist South Asia 366.442 372.814 392.118 473.959 391.023 357.53 299.831 371.146
Bengal* Europe 277.481 312.259 314.506 444.415 343.165 327.977 410.917 369.303
Ocicat* South Asia 250.81 272.05 285.371 362.082 289.028 245.677 244.482 272.293
*Indicates breeds that assigned to varying origins based on the genetic marker type.
Table 15b Assignment of cat breeds to random bred cat populations using STRs.
Breed STRs (N=38)
Lineage "-log(L)"
South East Europe East Me South Me Iraqlran Arabian India Asia Asia
Birman South Asia 619.802 624.199 691.233 784.48 627.696 611.122 404, .846 619.715
Burmese South Asia 538.86 574.707 602.871 650.149 543.725 469.352 328 .296 480.689
H. Brown South Asia 405.814 452.844 463.474 490.494 410.516 391.736 290 .886 348.305
Korat South Asia 724.631 720.932 769.557 773.995 605.694 574.06 298 .912 623.147
Siamese South Asia 440.302 476.476 511.011 515.028 452.232 377.384 268 .941 373.961
Singapura South Asia 529.943 593.678 581.331 723.339 530.853 516.217 377, .292 562.624
Abyssinian Europe 391.775 431.049 448.175 569.783 452.082 452.751 420, .303 462.802
Russian Blue South Asia 459.628 550.271 565.88 694.372 553.199 522.684 440, .046 531.117
American SH Europe 284.004 352.415 373.617 519.61 407.953 404.881 411. .122 413.971
British SH Europe 365.836 462.364 494.534 697.257 542.932 520.762 538 .64 553.998
Chartreux Europe 288.091 333.218 364.422 471.369 420.547 380.17 383 .442 377.357
Japanese Bob. Europe 442.684 492.594 504.049 586.241 498.245 472.916 486 .841 466.728
Maine Coon Europe 325.993 413.915 454.08 635.061 519.562 481.193 513, .901 510.841
Norwegian FC Europe 265.706 325.855 373.736 530.702 476.455 437.795 466 .9 454.453
Persian Europe 304.615 380.994 409.462 529.928 455.066 438.168 449, .052 414.575
Exotic SH Europe 431.298 514.268 536.769 706.318 563.227 579.773 541 , .912 574.013
Sphynx Europe 381.955 446.644 456.938 607.529 461.321 471.637 426 .769 491.009
Siberian Europe 272.587 305.993 346.585 514.722 453.233 405.521 428 .93 411.038
Egyptian Mau Europe 322.916 350.668 362.843 446.658 386.768 374.387 399 .565 412.49
Sokoke W Indian 275.548 271.011 274.846 286.448 218.947 248.466 244, .002 300.134
Turkish Angora * East Med 398.178 381.553 406.446 556.699 524.253 483.876 549 .764 539.647
Turksih Van East Med 452.401 387.724 427.429 577.663 525.23 477.131 505, .265 549.053
Cornish Rex Europe 369.25 437.788 446.038 555.609 468.858 428.47 394 .753 477.392
Manx Europe 280.006 354.58 393.541 589.955 496.761 463.125 499 .578 482.289
Ragdoll Europe 341.134 393.51 404.545 592.622 471.899 425.202 397 .716 405.643
Scottish Fold Europe 353.106 438.254 455.217 674.159 506.12 514.422 530, .18 525.99
Australian Mist South Asia 372.752 415.4 428.335 503.159 433.821 388.385 318 .639 384.275 Table 15b Assignment of cat breeds to random bred cat populations using STRs.
Breed STRs (N=38)
Lineage "-log(L)"
South East
Europe East Me South Me Iraqlran Arabian India Asia Asia
Bengal* W Indian 496.347 512.793 499.54 583.542 490.251 513.431 503.627 594.543 Ocicat* Europe 283.111 305.428 301.617 383.669 328.11 300.313 287.939 319.107
*Indicates breeds that assigned to varying origins based on the genetic marker type.
[0170] Assignment Testing. The accuracy of assignment testing varied depending upon not only the assignment method, but also the marker type used to differentiate the cat breeds. For example, when comparing the Bayesian method of Rannala & Mountain (1997) versus the Frequentist method of Paetkau et al. (2004), supra, the average sensitivity of assignment for the 148 non-phenotypic SNPs was 0.56 and 0.78, respectively (Table 16). When the five phenotypic SNPs were included with the random SNPs, the average assignment sensitivity was 0.54 and 0.83, respectively. Overall, the STRs had higher average sensitivities of 0.83 and 0.88, respectively. In six breeds, adding phenotypic SNPs into the Frequentist assignment of individuals reduced the sensitivity of the test, and in five breeds it reduced specificity. As this may be due to the strength of selection imposed on these markers we looked to use the phenotypic SNPs as a method of post assignment verification of breed origin for these cats. For many breeds these single-gene traits are the sole selection criteria for breed allocation, and can be seen in the frequency of the causative mutation in the breed (Table 14). Using just the five phenotypic SNPs included in this study, it was possible to correct for miss-assignment of individuals post-assignment testing in 57.5% of the individuals miss-assigned by the Bayesian method and in 50% of the individuals incorrectly assigned by the Frequentist method (Table 17). This would increase the sensitivity and specificity of the Bayesian method to 0.746 and 0.772 respectively, and the Frequentist to 0.89 and 0.888, resulting in better resolution than the use of STRs alone. The influence of recent breed development on the mis-allocation of individuals may be further visualized by plotting the crossed assignment rate as a function of the Reynold's distance between breeds (Figure 14). In all cases, the crossed assignment rate increased as the distance between breeds decreased. Table 16a - Assignment accuracy with the Bayesian method of Rannala & Mountain (Rannala & Mountain 1997).
Intergenic SNPs Intergenic and phenotypic SNPs STRs
Ave. Ave.
Breed n Ei EN Sens. Spec. Ave. Prot Ei Ell Sens. Spec. Prob. Ei Ell Sens. Spec. Prob.
* * *
Persian 12 12 0 0 10 0 0.17 1 2 13 0.83 0.43 0.57
Exotic SH 22 16 8 0.27 0.43 1 17 6 0.23 0.45 1 6 1 0.73 0.94 0.69
British SH 17 17 10 0 0 1 13 5 0.24 0.44 0.99 7 1 0.59 0.91 0.24
Scottish Fold 19 18 0 0.05 1 1 16 0 0.16 1 1 6 0 0.68 1 0.67
Chartreux 1 1 1 13 0.91 0.43 1 1 7 0.91 0.59 1 1 1 0.91 0.91 0.61
American SH 17 8 0 0.53 1 0.99 11 0 0.35 1 1 4 0 0.76 1 0.54
Sphynx 25 16 0 0.36 1 0.99 14 0 0.44 1 0.99 3 0 0.88 1 0.34
Japanese Bob. 18 2 33 0.89 0.33 1 7 34 0.61 0.24 1 1 0 0.94 1 0.55
Cornish Rex 23 12 0 0.48 1 0.97 14 0 0.39 1 0.98 5 0 0.78 1 0.58
* *
Ragdoll 16 16 0 0 16 0 0 5 0 0.69 1 0.6
Maine Coon 27 3 21 0.89 0.53 1 10 32 0.63 0.35 1 6 1 0.78 0.95 0.61
Abyssinian 1 1 4 0 0.64 1 0.98 4 0 0.64 1 0.98 2 0 0.82 1 0.54
*
Siberian 9 9 0 0 6 23 0.33 0.12 1 1 9 0.89 0.47 0.27
Manx 22 20 1 0.09 0.67 1 21 1 0.05 0.5 1 4 16 0.82 0.53 0.48
Egyptian Mau 14 3 0 0.79 1 1 4 0 0.71 1 1 1 0 0.93 1 0.59
Turkish Angora 18 5 125 0.72 0.09 1 11 134 0.39 0.05 1 11 2 0.39 0.78 0.46
Turkish Van 14 10 3 0.29 0.57 0.98 13 3 0.07 0.25 0.99 3 3 0.79 0.79 0.69
Bengal 23 7 0 0.7 1 1 2 0 0.91 1 0.99 0 0 1 1 0.79
Sokoke 5 0 0 1 1 1 0 0 1 1 1 0 0 1 1 0.81
Ocicat 7 4 0 0.43 1 0.99 3 1 0.57 0.8 0.99 1 0 0.86 1 0.63
Russian Blue 19 0 0 1 1 1 4 0 0.79 1 1 3 0 0.84 1 0.93
Australian Mist 20 0 1 1 0.95 1 0 2 1 0.91 1 2 15 0.9 0.55 0.92
Burmese 16 4 1 0.75 0.92 1 2 0 0.88 1 1 4 1 0.75 0.92 0.86
Birman 22 4 0 0.82 1 0.96 6 0 0.73 1 0.99 1 0 0.95 1 0.72
Havana Brown 15 2 2 0.87 0.87 1 2 1 0.87 0.93 1 0 0 1 1 0.93
Korat 24 0 15 1 0.62 1 0 17 1 0.59 1 2 0 0.92 1 0.55
Norwegian FC 16 8 4 0.5 0.67 1 5 25 0.69 0.31 1 2 25 0.88 0.36 0.41
*
Siamese 19 19 0 0 19 0 0 1 0 0.95 1 0.63
Singapura 19 1 0 0.95 1 1 0 0 1 1 1 2 0 0.89 1 0.86
All Breeds 500 221 237 0.56 0.54 0.99 231 291 0.54 0.48 1 86 88 0.83 0.82 0.63
* Essentially zero due to lack of sensitivity, n = Number of samples from this breed tested over ten iterations, Έι = Members of a breed that were incorrectly assigned to another breed, En Members of a different breed that were incorrectly assigned to the breed in question, Sens. = Sensitivity, Spec. = Specificity, Ave. Prob. = Average Probability of assignment.
Table 16b - Assignment accuracy with the Frequentist method of Paetkau et al. (Paetkau et al. 2004).
Intergenic SNPs Intergenic and phenotypic SNPs STRs
Ave.
Breed n Ei EN Sens. Spec. Ave. Prob Ei EN Sens. Spec. Ave. Prob. Ei En Sens. Spec. Prob.
Persian 12 9 19 0.25 0.14 0.39 6 10 0.5 0.38 0.45 1 6 0.92 0.65 0.26
Exotic SH 22 19 7 0.14 0.3 0.43 10 5 0.55 0.71 0.37 4 1 0.82 0.95 0.39
British SH 17 10 6 0.41 0.54 0.45 5 4 0.71 0.75 0.33 5 3 0.71 0.8 0.16
Scottish Fold 19 10 0 0.47 1 0.84 10 0 0.47 1 0.85 2 0 0.89 1 0.45
Chartreux 11 2 0 0.82 1 0.31 2 0 0.82 1 0.31 0 0 1 1 0.15
American SH 17 1 0 0.94 1 0.53 4 0 0.76 1 0.6 2 0 0.88 1 0.27
Sphynx 25 3 2 0.88 0.92 0.32 3 2 0.88 0.92 0.31 1 0 0.96 1 0.25
Japanese Bobtail 18 4 0 0.78 1 0.29 3 0 0.83 1 0.26 1 0 0.94 1 0.29
Cornish Rex 23 5 0 0.78 1 0.29 4 1 0.83 0.95 0.3 2 0 0.91 1 0.25
Ragdoll 16 3 0 0.81 1 0.26 2 0 0.88 1 0.26 4 0 0.75 1 0.32
Maine Coon 27 5 8 0.81 0.73 0.44 1 13 0.96 0.67 0.44 6 5 0.78 0.81 0.35
Abyssinian 11 0 0 1 1 0.32 0 0 1 1 0.32 2 0 0.82 1 0.33
Siberian 9 5 3 0.44 0.57 0.19 4 3 0.56 0.63 0.22 0 18 1 0.33 0.11
Manx 22 8 11 0.64 0.56 0.33 5 9 0.77 0.65 0.4 4 12 0.82 0.6 0.14
Egyptian Mau 14 1 0 0.93 1 0.29 2 0 0.86 1 0.32 3 0 0.79 1 0.18
Turkish Angora 18 10 1 0.44 0.89 0.23 6 8 0.67 0.6 0.37 9 7 0.5 0.56 0.21
Turkish Van 14 5 3 0.64 0.75 0.27 4 2 0.71 0.83 0.37 2 3 0.86 0.8 0.18
Bengal 23 2 0 0.91 1 0.43 2 0 0.91 1 0.43 0 0 1 1 0.21
Sokoke 5 0 0 1 1 0.41 0 0 1 1 0.42 0 0 1 1 0.46
Ocicat 7 0 1 1 0.88 0.27 0 2 1 0.78 0.3 1 1 0.86 0.86 0.1
Russian Blue 19 0 0 1 1 0.31 1 0 0.95 1 0.32 3 0 0.84 1 0.39
Australian Mist 20 0 2 1 0.91 0.57 0 3 1 0.87 0.58 2 1 0.9 0.95 0.27
Burmese 16 2 2 0.88 0.88 0.51 3 0 0.81 1 0.51 0 2 1 0.89 0.26
Birman 22 1 0 0.95 1 0.39 1 0 0.95 1 0.38 1 0 0.95 1 0.34
Havana Brown 15 1 0 0.93 1 0.48 2 1 0.87 0.93 0.49 0 0 1 1 0.37
Korat 24 1 0 0.96 1 0.41 0 0 1 1 0.42 0 0 1 1 0.45
Norwegian FC 16 1 46 0.94 0.25 0.33 3 20 0.81 0.39 0.37 1 3 0.94 0.83 0.06
Siamese 19 1 0 0.95 1 0.33 0 0 1 1 0.32 0 0 1 1 0.17
Singapura 19 1 0 0.95 1 0.45 0 0 1 1 0.44 3 0 0.84 1 0.32
All Breeds 500 110 111 0.78 0.78 0.39 83 83 0.83 0.83 0.39 59 62 0.88 0.88 0.27
* Essentially zero due to lack of sensitivity, n = Number of samples from this breed tested over ten iterations, Έι = Members of a breed that were incorrectly assigned to another breed, En Members of a different breed that were incorrectly assigned to the breed in question, Sens. = Sensitivity, Spec. = Specificity, Ave. Prob. = Average Probability of assignment.
Table 17
Total mis-assigned individuals identified post-assignment by phenotypic SNPs.
Assigned by SNPs Assigned by STRs
Bayesian Frequentist Bayesian Frequentist
Total Freq. Total Freq. Total Freq. Total Freq.
Long Hair 105 0.49 37 0.34 11 0.128 11 0.18
Burmese Points 15 0.07 3 0.03 1 0.016 2 0.03
Siamese Points 15 0.07 16 0.15 6 0.07 3 0.05
Chocolate 8 0.04 0 0 2 0.023 0 0
Cinnamon 14 0.07 5 0.05 4 0.047 4 0.07
Total* 127 0.58 55 0.5 22 0.256 19 0.31
Frequency (SNPs: Bayesian = 221, Frequentist = 110 STRs: Bayesian = 86, Frequentist = 62) *A few individuals were identified as mis-assigned with multiple phenotypic SNPs.
Discussion:
[0171] The artificial selection and population dynamics of domestic cats and its associated fancy breeds are unique amongst domesticated species. Cats are one of the more recent mammalian domesticates, arguably they exist in a unique quasi-domesticated state. Unlike other agricultural species and the domestic dog, for thousands of years, cats have had minimal artificial selection pressures on their form and function as they have naturally performed their required task of vermin control. Cats are transported between countries via accidental human-mediated travel or by direct importations, reducing barriers to gene flow; however, rabies control legislation has reduced the migration of cats between some countries. Overlapping niches between the wildcat progenitors, random bred feral cats, random bred house cats, and fancy breeds likely produces continual, however limited, gene flow throughout domestic cat world.
[0172] The overall selection on the cat genome may be predicted as less intense than in other domesticated species and their breeds. The cat fancy is less than 200 years old, and a majority of cat breeds were developed in the past 50 - 75 years. Human selection has focused on aesthetic qualities, such as coat colors and fur types, as opposed to complex behaviors, such as hunting skills, meat or milk production. Many of the cat's phenotypic traits, even ones that affect body and appendage morphologies, are simple traits with basic Mendelian inheritance patterns. One simple genetic change, such as long hair of the Persian versus short hair of the Exotic Shorthair, can be the defining characteristic between two breeds. Cat registries have recognized that some breeds are "natural", such as the Korat and Turkish Van, being specific population isolates, therefore random bred cats of similar origins can be used to augment the gene pools of these selected breeds. Other breeds are recognized as "hybrids", developed from purposeful cross-breeding. Breeds that are interspecies hybrids also exist in the cat fancy, such as the Bengal, which is a hybrid between an Asian leopard cat and various domestic breeds, such as Abyssinian and
Egyptian Mau. Thus, some cat breeds may be a concoction of various genetic backgrounds.
[0173] Breed assignment studies of cats can be of great value to humans and the cat itself in a variety of applications. As models for human disease, cat population structuring is important to the proper selection of cases and controls in the study design of genome- wide association studies. Cross-bred cats may unknowing transport undesired mutations into na'ive breed populations, and affect the breed's health and veterinary care. Polycystic kidney disease (PKD) is found in roughly 40% of Persians worldwide and has been documented in breeds with Persian influence, such as Scottish Folds and British Shorthairs (Lyons et al. (2004) Journal of the American Society of Nephrology, 15:2548-2555). The identification of migrants or hybridized individuals may affect the registration policies of a breed association. Out of curiosity, many of the lay public may like to know the origins of their cat and if their cat has pedigreed roots. Thus, this study has focused on the feasibility and power of genetic markers to delineate 29 of the world's cat breeds. SNPs and STRs were evaluated to assess the effects of genetic markers with different mutation rates on domestic cat regional clustering, breed clustering, and individual breed assignment. The selected 29 breeds were expected to represent the major breeds of the cat fancy. Several breeds were purposely selected that had been clearly derived from another breed, such as Persians and Exotics, while others were selected because they were recently developed hybrid breeds, such as the Ocicat and the Australian Mist. More slowly evolving SNPs and relatively quickly evolving STRs were examined as to their power to resolve these cat breeds that have different patterns and ages of ancestry.
[0174] Genetic Diversity. Significant genetic variation is present in many cat breeds. The Turkish Angora, a breed from Turkey, an area near the seat of cat
domestication, had the highest effective number of alleles for both SNPs and STRs. A continuum of increasing heterozygosity and decreasing inbreeding, whether SNP- or STR- based, is found between the least variable and most variable domesticated cat breeds. Two of the more popular breeds of the USA and the world are Persians and Bengals (on the internet at tica.org/). Persians were one of the first breeds to be recognized and Bengals, although only introduced in the past 40 years have risen to worldwide fame. Both breeds had moderate levels of heterozygosity and inbreeding. Several less popular breeds, such as the Cornish Rex, had fairly high levels of variation and low inbreeding. Two relatively new breeds, the Siberian and Ragdoll, have high variation, perhaps a reflection of their recent development from random bred populations. Thus, levels of variation and inbreeding cannot entirely be predicted based on breed popularity and breed age, implying management by the cat breeders may be the most significant dynamic for breed genetic population health. Interestingly, the Burmese had one of the highest levels of inbreeding and lowest levels of genetic variation. Burmese were established in the post- World War II breed boom, and has been a moderately popular breed. However, concerns for two diseases, a craniofacial defect and hypokalemia, has limited migration of cats between countries and within the USA. Fractionation of the breeding pool by color preferences within the USA has also caused poor breeding dynamics. Thus, a reduction in observed heterozygosity due to the Wahlund- effect may be likely, resulting in an under-estimation of the already severely high inbreeding coefficients, possibly sending the Burmese into extinction. A breed management plan that balances diversity, health and breed type may need to be implemented to help the Burmese breed survive.
[0175] Breed Clustering. The most likely value of K, the number of structured groupings, could not be decisively determined. Several factors that violate many of the assumptions in the models implemented by Structure may have caused this difficulty. Cat breeds have variation in age of development, significantly different genetic population origins, and the variation in breeding practices can create distinct lines within one breed that may be as unique as one of the more recently established breeds. Many breeds were created through the crossing of two often highly divergent populations of cats resulting in a hybrid of sorts while other breeds still allow the introduction of cats from random bred populations. However, the Bayesian cluster analysis supported the breed demarcations from previous studies, especially the STR analyses of Lipinski et al. (2007) Animal Genetics, 38, 371-377. Previously, 22 breeds, which included 15 of 16 "foundation" cat breeds designated by the Cat Fanciers Association, delineated as 17-18 separate populations. This study added seven additional breeds, including the missing 16th "foundation" breed, the Manx. As in previous studies, the novel breeds that were not deemed significantly distinct from another breed can be very clearly explained by the breed history. The two large breed families of Siamese and Persians were re-identified and the Persian family expanded with Scottish Folds. In addition to the previously recognized grouping of the Siamese / Havana Brown, the Australian Mist, which was created by cross-breeding with Burmese, grouped with the Burmese. However, more recent breeds, such as Ragdoll and Bengal, are resolved as separate breed populations, suggesting STRs alone can differentiate about 24 of 29 breeds, as well as Turkish-origin versus USA-origin Turkish Angoras. At K = 17, SNPs could not differentiate the Singapura, however, the Birman separation from other Asiatic breeds could be defined. Thus, both sets of markers provide valuable insight to the relationship of the breeds.
[0176] Regional Clustering. Regardless of the marker assayed and using both
Bayesian assignment testing and principal coordinate analyses, the majority of the breeds assigned back to the random bred population most influential to the creation of that breed, as suggested by popular breed histories. Sixteen breeds originate from European populations, six breeds form South Asian populations, two breeds from the Eastern
Mediterranean, the Turkish Van and the Turkish Angora, and the Sokoke from the Arabian Sea region. However, some exceptions were noted depending on the marker of analysis. For SNPs versus STRs, the Turkish Angora assigned to the Eastern Mediterranean or
Europe, respectively, Bengal assigned to the Arabian Sea or Europe, respectively, and the Ocicat assigned to Europe or South Asia, respectively. The Turkish Angora breed was reconstituted from the Persian (European) pedigree post World Wars and recently, has been increasing genetic diversity via the outcrossing of pedigreed Turkish Angora cats to the random bred cats of Turkey. The identified lineages within the breed may be identifying the recent influx of random bred cats. The confusion in the Bengal and the Ocicat assignments could be a result of the contribution of the Abyssinian and Egyptian Mau and the Abyssinian and the Siamese, respectively, which are breeds with different regional assignments.
[0177] Assignment Testing. Overall, the Frequentist method of Paetkau et al.
(2004), supra, outperformed the Bayesian method of Rannala and Mountain (1997), supra. In addition, while the 38 highly polymorphic STRs consistently outperformed the SNPs, the addition of phenotypic SNPs as a post-assignment verification significantly improved the assignment rates using the frequentist method. For the 29 breeds, when intergenic SNPs were used with the frequentist method for assignment, the sensitivity of assignment was equal to or better than that of the STRs in 12 breeds and the specificity in 19 breeds. With the addition of only five phenotypic determining SNPs, specificity improved to 15 breeds, equaling or surpassing in the sensitivity of assignment of the STRs and 19 breeds equaling or outperforming in specificity of assignment.
[0178] In six breeds, adding phenotypic SNPs into the frequentist assignment of individuals reduced the sensitivity of the test, and in five breeds it reduced specificity. As this may be due to the strength of selection imposed on these markers we looked to use the phenotypic SNPs as a method of post assignment verification of breed origin for these cats. For many breeds these single-gene traits are the sole selection criteria for breed allocation, and can be seen in the frequency of the causative mutation in the breed (Table 14). In general, breeds that were more inbred and both not used in outcrosses, nor developed through the crossing of pre-existing breeds had a higher accuracy in reassignment. Breeds such as the Russian Blue, Sokoke and Abyssinian are examples of such. In contrast, breeds where outcrossing is common either with other breeds or random bred populations tended to confuse the assignment algorithm and had a high probability of both Type I and II error. These would be breeds such as the Persians, Turkish Angoras, Siamese and Ragdoll. The most common error in assignment by far was cross assignment between Exotic shorthairs and Persians -a problem easily remedied through exploiting the FGF5 SNP shown to cause long hair in Persians.
[0179] The influence of recent breed development on the mis-allocation of individuals may be further visualized by plotting the crossed assignment rate as a function of the Reynold's distance between breeds (Figure 11). In all cases, the crossed assignment rate increased as the distance between breeds decreased. This correlates exactly with what would be expected. Breeds that are considered separate solely on a color variant or hair length would be very close genetically and as a result, more prone to cross assignment.
[0180] The advantage was tipped in favor of SNPs when the five phenotypic SNPs were included as a post-assignment check. Initially, cats could be localized to a regional population and a breed family by STRs and / or SNPs. Secondary differentiation within the breed family could be determined by genotyping mutations for phenotypic traits, especially traits that are breed specific to or fixed within a breed. Some traits are required for breed membership; a Birman or Siamese must be pointed, implying homozygous for the G940A TYR mutation. Some traits are grounds for exclusion, all Korats are solid blue, no other colors or patterns are acceptable. Therefore, a trait such as the long haired A475C FGF5 mutation could be used as a means for identifying members of the Persian, Maine Coon, Turkish Angora, Turkish Van and Birman breeds, and likewise a means for discrimination as an exclusion maker for breeds such as the Abyssinian, Egyptian Mau, Sokoke and Ocicat. Other single gene traits may be used to identify members of a small family of cat breeds as well, such as the Burmese points, G715T TYR, are a prerequisite for membership to the Burmese and Singapura breeds, and Siamese points, G940A TYR, as their name suggests, are a requirement for Birmans, Himalayans and, of course, Siamese cats. The cinnamon mutation, C298T TYRP1, is very rare and is common to the red Abyssinian. Certain dominant traits can be homozygous or heterozygous, such as the ear curl of American Curls or the bobtail of the Japanese Bobtail. Some dominant traits are homozygous lethal in utero, such as tailless of the Manx (Todd (1961) Journal of Heredity, 52:228-232), or cause health problems, such as osteochondroplasia caused by the ear fold mutation in Scottish
Folds (Malik et al. (1999) Australian Veterinary Journal, 77:85-92). As a result, the breed may have cats that conform to the breed except do not express the breed-specific trait, such as straight-eared Scottish Folds, or tailed Manx. These varieties would currently be difficult to distinguish within the breed family or region. [0181] Cat fancy registries may not agree with assignments due to breeding restrictions. The Tonkinese, which is genetically compound heterozygous for the G940A and the G715T TYR mutations, can produce both pointed and sepia cats, thus they would genetically resemble a Siamese or Burmese, respectively. However, breeding restrictions would not allow these Tonkinese variants to be registered as Siamese or Burmese. Since the development of this SNP panel, additional phenotypic SNPs have been discovered in cats including the Norwegian Forest Cat color variant amber (Peterschmitt et al. (2009) Animal Genetics, 40:547-552), three additional long-haired mutations (Kehler et al. (2007) Journal of Heredity, 98:555-566), and the mutations responsible for hairless of Sphynx and rexing of the Devon Rex (Gandolfi et al, Mamm Genome. (2010) (9-10):509-15). These additional mutations, as well as disease mutations, could further delineate cat breeds.
[0182] Conclusions. Aside from the public interest in knowing their prized family pet is descendent from a celebrated pedigree, breed assignment is a vital tool in tracing the spread of genetically inherited diseases throughout the cat world. Much like humans and dogs, certain populations of cats are known to be at higher risk for particular diseases, such as heart disease in the Maine Coon and Ragdoll (Meurs et al. (2005) Human Molecular Genetics, 14:3587-3593; Meurs et al. (2007) Genomics, 90:261-264), polycystic kidney disease in the Persian (Lyons et al. 2004, supra), and progressive retinal atrophy in the Abyssinian (Menotti-Raymond et al. (2007) Journal of Heredity, 98:211-220). Knowing if a particular feline descended from one of these at risk populations may influence treatments in a clinical setting and help us to better care for our animal companions. With additional phenotypic and perhaps disease-causing SNPs, the power of this STR / SNP panel to accurately assign individuals to specific cat breeds would be greatly increased, in particular those breeds that are defined expressively by single-gene traits.
Example 3
Tables of Population Clustering at Different K Values
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 8 10 11 12 13 14 15 16 17 18 19 20 2
Persian 1250 7 0.7866 0.0682 0, 0114 0.0031 0.0048 0.0039 ,0064 0.0035 0031 0.039 0.0066 0.0059 0.0096 0.0033 0.0022 0.0014 0.0065 0.0085 0.0035 0.0099 0. Persian 1939 13 0.5479 0.0033 0. 134 0.0038 0.022 0.002 ,004 0.0053 001 0.003 0.2157 0.002 0.0043 0.0023 0.0033 0.0033 0.0021 0.0033 0.001 0.0354 0. Persian 2071 18 0.7477 0.0207 0. 0379 0.0036 0.0045 0.0095 ,0277 0.0095 00330.0028 0.006 0.0073 0.0095 0.0048 0.0032 0.0043 0.003 0.0199 0.0082 0.0066 O. Persian 2088 21 0.9342 0.0063 0, 0037 0.0028 0.0063 0.0038 ,0028 0.006 0021 0.002 0.0034 0.0092 0.0019 0.0026 0.0023 0.0017 0.0018 0.0019 0.002 0.0021 O. Persian 2140 10 0.8648 0.0117 0, 0038 0.0056 0.0028 0.0059 ,0063 0.0127 003 0.0079 0.0117 0.0031 0.0047 0.0023 0.0019 0.0024 0.0199 0.0065 0.0036 0.0135 O. Persian 2174 10 0.9585 0.002 0, 0016 0.001 0.002 0.001 ,001 0.002 001 0.001 0.0019 0.002 0.0018 0.0021 0.0116 0.0022 0.0013 0.001 0.001 0.003 O. Persian 2209 10 0.6727 0.0023 0, 0058 0.0048 0.0176 0.002 ,0021 0.0022 002 0.1571 0.0055 0.0065 0.002 0.0022 0.0017 0.0019 0.0032 0.0043 0.0818 0.0081 O. Persian 2215 18 0.6827 0.0013 0, 0057 0.0227 0.001 0.0086 0 ,0058 0.0137 01080.0209 0.066 0.0157 0.0094 0.0021 0.0012 0.0026 0.0023 0.0027 0.0026 0.1183 O. Persian 2890 10 0.9745 0.0012 0. 002 0.001 0.0011 0.001 0 ,0019 0.0018 00120.001 0.0011 0.001 0.001 0.001 0.001 0.001 0.0018 0.001 0.001 0.0017 O. Persian 2977 15 0.3524 0.0062 0, 1847 0.003 0.0022 0.001 0 ,0047 0.0155 00190.0392 0.2965 0.002 0.0065 0.0022 0.0115 0.0027 0.001 0.001 0.002 0.0628 O. Persian 4143 7 0.5399 0.0015 0, 1206 0.0053 0.0036 0.0022 0 ,0029 0.025 00770.0071 0.2098 0.002 0.0026 0.0058 0.0025 0.0027 0.0072 0.0019 0.0046 0.0437 O. Persian 4168 7 0.88 0.0049 0, 0032 0.0038 0.0527 0.002 0 ,02 0.002 001 0.003 0.0036 0.0022 0.0025 0.0023 0.0023 0.0019 0.0031 0.0014 0.0017 0.0052 O. Persian 4169 7 0.9097 0.0074 0, 0108 0.0041 0.002 0.0202 0 ,0075 0.0028 0021 0.0051 0.0068 0.0036 0.0023 0.0018 0.0027 0.0017 0.0016 0.002 0.0018 0.0028 O. Persian 4950 7 0.8748 0.0039 0, 0049 0.0049 0.0019 0.0125 0 ,0026 0.0055 001 0.0039 0.0077 0.0049 0.0132 0.0051 0.003 0.007 0.0036 0.0037 0.0302 0.003 O. Persian 4953 15 0.9194 0.0027 0. 0058 0.0024 0.0021 0.0012 0 0022 0.0098 002 0.0025 0.0045 0.0217 0.0057 0.0044 0.0035 0.0014 0.002 0.001 0.001 0.0031 O. Exotic SH 258 15 0.8256 0.0051 0. 003 0.0113 0.0015 0.005 0 ,0082 0.002 002 0.0024 0.006 0.0037 0.0833 0.0028 0.0021 0.0014 0.002 0.0238 0.0044 0.0031 O. Exotic SH 259 7 0.9005 0.0029 0, 0057 0.0075 0.004 0.0066 0 ,0102 0.0187 001 0.0034 0.0026 0.0025 0.0044 0.0011 0.0014 0.0013 0.001 0.001 0.001 0.0215 O. Exotic SH 260 5 0.9608 0.0037 0, 0023 0.0028 0.0035 0.0024 0 ,0021 0.0034 001 0.002 0.002 0.001 0.002 0.0018 0.0015 0.0019 0.001 0.001 0.0012 0.0016 O. Exotic SH 261 7 0.8958 0.0065 0, 0091 0.0085 0.0025 0.0053 0 ,001 0.0033 002 0.0073 0.0114 0.0092 0.0071 0.0072 0.0112 0.0024 0.0012 0.001 0.003 0.0036 O. Exotic SH 262 7 0.9025 0.018 0, 0032 0.0158 0.0016 0.0069 0 ,0028 0.0068 0041 0.003 0.0037 0.002 0.0034 0.0046 0.0036 0.0025 0.0019 0.0043 0.0033 0.0048 O. Exotic SH 263 10 0.9234 0.0056 0, 0041 0.0091 0.0024 0.0019 0 ,0022 0.01 00130.0072 0.0044 0.005 0.0021 0.0034 0.0019 0.0024 0.0026 0.0022 0.001 0.0066 O. Exotic SH 264 7 0.6501 0.0031 0. 0266 0.1467 0.0838 0.0011 0 ,0107 0.0014 002 0.0138 0.0077 0.0023 0.0104 0.0012 0.0024 0.0062 0.0082 0.0057 0.0027 0.0115 O. Exotic SH 265 18 0.8689 0.0033 0, 005 0.0032 0.0029 0.006 0 ,008 0.003 00340.01 0.0069 0.002 0.0026 0.0033 0.0025 0.0021 0.0058 0.006 0.0061 0.004 O. Exotic SH 266 7 0.9553 0.002 0, 0021 0.0041 0.004 0.001 0 ,0019 0.002 001 0.0017 0.0022 0.001 0.001 0.0016 0.001 0.001 0.0116 0.001 0.002 0.0015 O. Exotic SH 267 7 0.9372 0.0019 0, 0015 0.016 0.002 0.002 0 ,0029 0.002 00170.0019 0.0019 0.001 0.0015 0.0041 0.0045 0.0089 0.0015 0.0019 0.0018 0.0025 O. Exotic SH 268 18 0.8783 0.009 0, 0056 0.0105 0.0021 0.0018 0 ,0052 0.0024 00230.0039 0.0053 0.0054 0.0024 0.0023 0.007 0.0016 0.0233 0.0034 0.0219 0.0028 O. Exotic SH 269 5 0.9549 0.0019 0, 0031 0.0046 0.0028 0.0019 0 ,0018 0.0033 0011 0.0018 0.0023 0.0026 0.0019 0.0015 0.0023 0.0017 0.0018 0.0018 0.0035 0.0016 O. Exotic SH 270 5 0.9377 0.0061 0. 0022 0.0131 0.002 0.0042 0 ,0025 0.0027 001 0.0022 0.0024 0.0012 0.0028 0.0011 0.001 0.0011 0.0022 0.0011 0.001 0.0112 O. Exotic SH 271 7 0.9563 0.0043 0. 0029 0.0018 0.0021 0.0023 0 ,001 0.0032 002 0.002 0.0024 0.0019 0.0019 0.0019 0.0016 0.0019 0.0018 0.0025 0.0022 0.003 O. Exotic SH 272 7 0.7489 0.0021 0, 003 0.1869 0.0021 0.0023 0 ,0023 0.005 00330.0044 0.0033 0.002 0.0037 0.0021 0.0085 0.0024 0.0018 0.0032 0.0036 0.0074 O. Exotic SH 273 5 0.9224 0.0056 0, 0036 0.0036 0.0019 0.0028 0 ,002 0.0032 00450.0057 0.006 0.0073 0.0028 0.0035 0.0025 0.0016 0.0114 0.0019 0.0018 0.0033 O. Exotic SH 274 15 0.9178 0.0023 0, 0066 0.0013 0.0054 0.004 0 ,0073 0.0041 00260.0034 0.0056 0.0018 0.0062 0.002 0.0035 0.003 0.0137 0.0022 0.001 0.004 O. Exotic SH 275 10 0.8779 0.002 0, 0029 0.0111 0.0021 0.0028 0 ,0241 0.0014 01040.002 0.0022 0.0018 0.0018 0.0016 0.0011 0.0017 0.0054 0.0022 0.0377 0.0031 O. Exotic SH 276 7 0.9058 0.0039 0, 0076 0.008 0.0011 0.0021 0 ,0044 0.0058 00320.0043 0.0064 0.0028 0.0022 0.0029 0.0017 0.0012 0.002 0.0036 0.0014 0.004 O. British SH 156 5 0.6905 0.0221 0. 0172 0.0044 0.002 0.0108 0 ,0018 0.0048 01120.005 0.0087 0.0042 0.006 0.004 0.0027 0.0013 0.002 0.0028 0.001 0.1936 O. British SH 157 5 0.7973 0.0148 0, 0172 0.0053 0.009 0.0068 0 ,0057 0.0077 00820.004 0.006 0.0034 0.0078 0.0032 0.002 0.0017 0.001 0.0028 0.0041 0.0852 O. British SH 158 5 0.5086 0.0079 0, 1649 0.002 0.0095 0.003 0.004 0.0117 003 0.0101 0.1597 0.0021 0.0036 0.0024 0.0023 0.0024 0.0011 0.0017 0.001 0.0928 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 6 8 10 11 12 13 14 15 16 17 18 19 20 21
British SH 159 5 0.6213 0.063 0 0035 0.0065 0.0274 0.0029 0, 0031 0.0062 0.00250.0458 0.0077 0.003 0.002 0.0061 0.0027 0.0023 0.0042 0.0081 0.0037 0.1741 0.
British SH 160 7 0.7633 0.0026 0 01 0.002 0.0018 0.0025 0, 001 0.0037 0.0021 0.0018 0.0016 0.001 0.0019 0.0021 0.001 0.001 0.001 0.001 0.001 0.1958 0.
British SH 161 5 0.6705 0.017 0 0622 0.002 0.0021 0.0085 0, 0056 0.0081 0.002 0.003 0.0025 0.0025 0.0032 0.0025 0.0017 0.0022 0.0141 0.0013 0.001 0.1828 0.
British SH 162 5 0.5013 0.0683 0 188 0.002 0.002 0.0024 0.0019 0.0047 0.00360.0104 0.0055 0.0038 0.0044 0.0061 0.0026 0.0018 0.0359 0.0021 0.0011 0.151 0.
British SH 163 5 0.4522 0.1998 0 0046 0.0033 0.0609 0.004 0.0053 0.0056 0.0021 0.0215 0.0036 0.0137 0.0077 0.003 0.006 0.0013 0.0352 0.0025 0.0421 0.1228 O.
British SH 164 5 0.5118 0.0989 0 1951 0.003 0.0029 0.0044 0, 0013 0.0049 0.002 0.0234 0.0037 0.002 0.0028 0.0019 0.0077 0.0013 0.0034 0.001 0.0027 0.124 O.
British SH 165 10 0.6535 0.0691 0 0123 0.003 0.0018 0.0059 0, 0061 0.0059 0.00390.0145 0.0055 0.0208 0.0065 0.002 0.0023 0.0059 0.0028 0.0021 0.0014 0.1721 O.
British SH 166 7 0.8077 0.0026 0 007 0.019 0.0107 0.0063 0, 0122 0.0104 0.01060.0029 0.0032 0.0041 0.0026 0.0034 0.0011 0.0026 0.0067 0.0023 0.011 0.0688 O.
British SH 167 7 0.4173 0.038 0 314 0.0094 0.0059 0.002 0, 0196 0.0156 0.002 0.023 0.0386 0.002 0.0138 0.005 0.0015 0.0022 0.0145 0.0044 0.0044 0.0638 O.
British SH 168 5 0.721 0.0019 0 0027 0.003 0.0019 0.0017 0, 0259 0.003 0.00560.003 0.0101 0.0145 0.002 0.0019 0.0034 0.0038 0.0012 0.0404 0.0052 0.1342 O.
British SH 169 5 0.8963 0.004 0 0084 0.004 0.0042 0.002 0.0066 0.0042 0.00820.0037 0.0057 0.0047 0.014 0.0036 0.0024 0.003 0.0011 0.001 0.0084 0.0125 O.
British SH 170 7 0.7456 0.0052 0 0136 0.002 0.001 0.001 0, 001 0.0281 0.00180.0027 0.0034 0.002 0.0055 0.0011 0.009 0.0024 0.001 0.001 0.0011 0.1704 O.
British SH 171 5 0.7699 0.0017 0 0014 0.0027 0.001 0.0032 0, 0038 0.0025 0.00420.0021 0.0027 0.0032 0.0021 0.0032 0.001 0.0017 0.0012 0.0013 0.001 0.1891 O.
British SH 172 5 0.7388 0.0026 0 0021 0.0022 0.002 0.0033 0, 0011 0.0034 0.00190.0012 0.0012 0.001 0.001 0.0011 0.001 0.0016 0.0025 0.0085 0.0028 0.2084 O.
British SH 173 7 0.6843 0.0123 0 0075 0.002 0.0019 0.0631 0, 0031 0.0052 0.00350.003 0.0032 0.0018 0.003 0.0061 0.007 0.0016 0.0053 0.0014 0.001 0.1806 O.
Scottish Fold 5655 7 0.6005 0.0301 0 0652 0.0178 0.0021 0.0022 0, 0048 0.0196 0.01090.0086 0.019 0.0021 0.0105 0.0077 0.001 0.0013 0.0578 0.0038 0.0021 0.1304 O.
Scottish Fold 5669 2 0.7467 0.0172 0 0347 0.0032 0.0048 0.0032 0.024 0.0113 0.01780.0021 0.0278 0.002 0.0057 0.0016 0.0016 0.0025 0.0097 0.0017 0.001 0.0803 O. Scottish Fold 7205 5 0.5549 0.1066 0 1134 0.0039 0.0027 0.0024 0.0331 0.0033 0.00290.0128 0.009 0.0014 0.0031 0.002 0.003 0.0176 0.0037 0.0023 0.0032 0.1174 O. Scottish Fold 7260 7 0.4461 0.0055 0 0897 0.0059 0.0046 0.0054 0, 0028 0.0026 0.07850.0443 0.2661 0.0025 0.002 0.0011 0.0013 0.0032 0.0035 0.001 0.001 0.0319 O. Scottish Fold 8552 7 0.7094 0.0031 0 0065 0.0077 0.004 0.0023 0, 0042 0.0148 0.00290.0067 0.0063 0.0019 0.0078 0.0023 0.002 0.0109 0.0085 0.0013 0.0013 0.1806 O. Scottish Fold 9823 5 0.7631 0.0033 0 0035 0.0022 0.0017 0.0018 0, 0012 0.0028 0.00270.0029 0.0042 0.0029 0.0018 0.0011 0.0011 0.0022 0.0018 0.0017 0.001 0.1957 O. Scottish Fold 9824 5 0.7671 0.0015 0 0045 0.0018 0.002 0.0017 0, 002 0.0115 0.00180.002 0.0041 0.001 0.0013 0.0012 0.0013 0.0014 0.001 0.0015 0.001 0.1885 O. Scottish Fold 9825 7 0.7611 0.0037 0 0031 0.0024 0.003 0.0021 0, 0018 0.0028 0.00280.0035 0.0032 0.0018 0.002 0.0014 0.0015 0.0019 0.001 0.0019 0.0014 0.1948 O. Scottish Fold 9826 5 0.7696 0.0032 0 0035 0.0018 0.0018 0.0028 0.001 0.0025 0.00170.0018 0.0023 0.0017 0.001 0.001 0.0011 0.0017 0.0018 0.001 0.001 0.1967 O. Scottish Fold 9827 7 0.7742 0.0012 0 0029 0.0019 0.003 0.001 0, 001 0.0028 0.0011 0.002 0.0018 0.0015 0.0014 0.001 0.001 0.0022 0.002 0.001 0.001 0.195 O. Scottish Fold 9831 5 0.7659 0.0028 0 0026 0.002 0.0021 0.002 0, 001 0.0033 0.0041 0.002 0.0019 0.002 0.0019 0.0017 0.0011 0.0029 0.0018 0.0018 0.001 0.1943 O. Scottish Fold 9832 7 0.7597 0.0036 0 0037 0.002 0.004 0.0019 0, 0018 0.0037 0.00240.0029 0.0058 0.0018 0.0018 0.0011 0.0015 0.0031 0.001 0.001 0.0016 0.1946 O. Scottish Fold 9929 7 0.7189 0.0385 0 0118 0.0024 0.003 0.001 0, 0121 0.004 0.00190.0503 0.0078 0.0015 0.0296 0.0065 0.0028 0.0028 0.002 0.0017 0.001 0.0995 O. Scottish Fold 9930 7 0.5752 0.2529 0 0055 0.002 0.0033 0.0032 0, 0094 0.002 0.00290.0158 0.0039 0.001 0.002 0.0033 0.0016 0.0021 0.0011 0.001 0.001 0.1097 O. Scottish Fold 9931 7 0.5005 0.3098 0 0049 0.0023 0.0079 0.0015 0.0074 0.0027 0.00230.0052 0.0049 0.0031 0.0043 0.0026 0.004 0.0038 0.001 0.0027 0.001 0.1271 O. Scottish Fold 9937 5 0.3795 0.3982 0 0214 0.0035 0.001 0.0049 0. 0064 0.0155 0.00290.0072 0.0167 0.001 0.0056 0.0021 0.0019 0.0027 0.0017 0.0034 0.0027 0.1204 O. Scottish Fold 9965 5 0.4471 0.1745 0 2081 0.0056 0.002 0.002 0, 0017 0.002 0.00230.0057 0.0063 0.001 0.0037 0.0012 0.0095 0.0029 0.0019 0.001 0.0018 0.1188 O. Chartreux 1772 7 0.0063 0.8977 0 0381 0.0023 0.0046 0.0047 0, 0033 0.0023 0.00160.0021 0.0022 0.0018 0.0052 0.0018 0.0014 0.0017 0.0086 0.002 0.0043 0.0051 O. Chartreux 2226 15 0.0037 0.8556 0 0077 0.0397 0.0043 0.0042 0, 0065 0.0067 0.004 0.0123 0.0052 0.0033 0.0197 0.0022 0.0032 0.0026 0.0095 0.0014 0.0019 0.005 O. Chartreux 2229 26 0.028 0.7448 0 0033 0.0025 0.0026 0.0044 0, 0019 0.1111 0.009 0.0064 0.004 0.0019 0.0032 0.0041 0.0041 0.0025 0.0011 0.0011 0.0028 0.06 O. Chartreux 2524 5 0.0025 0.7292 0 1568 0.0113 0.0046 0.0062 0, 0095 0.0022 0.008 0.0094 0.0156 0.004 0.0038 0.0036 0.0042 0.0051 0.0025 0.0057 0.0024 0.0074 O. Chartreux 2787 13 0.0032 0.86 0 0504 0.0167 0.0028 0.002 0.0032 0.0039 0.00280.0032 0.0076 0.003 0.0026 0.0057 0.005 0.0044 0.0047 0.0044 0.0047 0.006 O. Chartreux 2805 15 0.0671 0.7312 0 0491 0.0042 0.0054 0.001 0.001 0.0027 0.00260.0039 0.0091 0.0192 0.0018 0.0017 0.0025 0.0012 0.0026 0.0025 0.0012 0.0866 O. Chartreux 2813 26 0.1312 0.5713 0 1405 0.0048 0.0038 0.006 0.0033 0.0076 0.0021 0.0173 0.0049 0.0074 0.002 0.0021 0.0094 0.0039 0.0041 0.0043 0.0023 0.0684 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Chartreux 2979 21 0.2175 0.663 0, 0037 0.0045 0.0032 0.0046 0 ,0067 0.0022 0021 0.0025 0.0054 0.002 0.0048 0.0088 0.0059 0.008 0.003 0.002 0.0056 0.0433 0.
Chartreux 4059 13 0.006 0.956 0, 002 0.0026 0.0026 0.0013 0 ,001 0.0013 001 0.0022 0.0027 0.0048 0.0013 0.0014 0.0017 0.0012 0.0019 0.0023 0.0021 0.0026 0.
Chartreux 4063 28 0.0128 0.9451 0, 0033 0.0035 0.0014 0.0014 0 ,0022 0.0012 002 0.0023 0.0028 0.0016 0.0021 0.002 0.0021 0.0023 0.004 0.0018 0.0021 0.0027 0.
Chartreux 5606 13 0.0031 0.9692 0. 0023 0.0013 0.0016 0.0017 0 ,0013 0.0017 0011 0.0013 0.0023 0.001 0.001 0.0011 0.0015 0.0011 0.0023 0.001 0.0013 0.0018 0.
Chartreux 5609 10 0.0013 0.9309 0. 0016 0.0028 0.0087 0.0021 0 ,0033 0.0025 00740.0024 0.0029 0.002 0.0036 0.0055 0.0013 0.0016 0.0041 0.0041 0.0024 0.0054 O.
Chartreux 5611 18 0.0236 0.9192 0, 0023 0.0114 0.0021 0.0024 0 ,0017 0.0091 00140.0023 0.0032 0.0031 0.002 0.0022 0.0018 0.0011 0.0034 0.0015 0.0013 0.0037 O.
American SH 143 5 0.0105 0.2447 0, 5894 0.008 0.0023 0.01 0 ,002 0.0088 00170.003 0.0082 0.079 0.005 0.0024 0.0027 0.0047 0.009 0.0013 0.001 0.0043 O.
American SH 144 5 0.0025 0.2937 0, 6791 0.0031 0.001 0.001 0 ,001 0.001 00230.0023 0.0017 0.001 0.001 0.001 0.0012 0.0011 0.001 0.001 0.001 0.0011 O.
American SH 145 5 0.0092 0.2629 0, 6655 0.0041 0.006 0.002 0 ,0013 0.0055 00230.0055 0.0044 0.0023 0.004 0.0024 0.0046 0.0014 0.0023 0.0023 0.001 0.0087 O.
American SH 146 5 0.0259 0.1959 0, 5457 0.0053 0.0016 0.0105 0 ,0231 0.0304 00320.0455 0.0179 0.001 0.0021 0.0027 0.0011 0.0021 0.0401 0.002 0.0018 0.0383 O.
American SH 3652 15 0.0039 0.2904 0. 6406 0.0052 0.0019 0.0097 0 ,0024 0.0057 00280.004 0.0094 0.001 0.0039 0.003 0.001 0.0012 0.0048 0.0018 0.0012 0.0036 O.
American SH 3653 5 0.0095 0.2145 0, 5634 0.0112 0.0516 0.003 0 ,0049 0.0235 01070.0135 0.0269 0.0051 0.022 0.0036 0.0033 0.0037 0.0035 0.0143 0.001 0.0056 O.
American SH 4363 10 0.0132 0.277 0, 673 0.0011 0.0013 0.0026 0 ,0025 0.0018 00450.0031 0.0023 0.002 0.0013 0.0017 0.001 0.0017 0.002 0.001 0.001 0.0034 O.
American SH 4370 7 0.0111 0.2027 0, 5732 0.0052 0.0131 0.0154 0 ,0298 0.0066 00250.0449 0.0106 0.001 0.0163 0.016 0.0043 0.0141 0.0023 0.0035 0.0124 0.0071 O.
American SH 4373 18 0.006 0.2785 0, 6691 0.002 0.0021 0.001 0 ,0015 0.0014 00130.0036 0.002 0.0141 0.0024 0.0021 0.0022 0.0019 0.0023 0.001 0.001 0.0019 O.
American SH 6404 13 0.0045 0.1919 0, 6085 0.0108 0.048 0.0023 0 ,002 0.0033 00250.0046 0.0041 0.003 0.0554 0.0014 0.0041 0.007 0.0376 0.0016 0.0022 0.0036 O.
American SH 6406 7 0.1731 0.1501 0. 5087 0.0093 0.0039 0.0624 0 ,0041 0.0121 002 0.0062 0.0153 0.0031 0.0074 0.0021 0.0061 0.0043 0.002 0.0017 0.0064 0.0184 O.
American SH 6410 7 0.2401 0.2059 0. 4241 0.0035 0.0037 0.0022 0 ,0019 0.0039 00140.0057 0.0038 0.0027 0.0033 0.0014 0.0026 0.0023 0.0036 0.002 0.0041 0.0803 O.
American SH 6421 13 0.0173 0.2621 0, 4855 0.0056 0.008 0.0156 0 ,004 0.045 00570.0076 0.0104 0.0434 0.0146 0.0079 0.0043 0.0161 0.002 0.0054 0.0042 0.0258 O.
American SH 2259 5 0.0059 0.2719 0, 6448 0.0012 0.0072 0.002 0 ,0037 0.0037 01780.0034 0.004 0.002 0.0032 0.0021 0.0066 0.0021 0.0035 0.0021 0.0054 0.0028 O.
Sphynx 277 10 0.0077 0.003 0, 0031 0.8871 0.0068 0.0256 0 ,0058 0.0026 00440.002 0.003 0.002 0.0021 0.0035 0.0018 0.0034 0.0021 0.0064 0.0081 0.0045 O.
Sphynx 278 7 0.0054 0.0143 0, 0078 0.9134 0.002 0.001 0 ,003 0.0027 002 0.0054 0.0103 0.0028 0.002 0.0029 0.0063 0.004 0.0064 0.002 0.0027 0.0023 O.
Sphynx 279 7 0.0035 0.0038 0, 0026 0.8939 0.003 0.012 0 ,0057 0.0314 003 0.0022 0.0045 0.0018 0.002 0.0023 0.001 0.0026 0.002 0.0061 0.0018 0.0126 O.
Sphynx 280 7 0.0046 0.0045 0. 0092 0.9188 0.0024 0.002 0 ,0074 0.003 0021 0.0029 0.0078 0.0035 0.0037 0.0017 0.002 0.003 0.01 0.0013 0.002 0.0026 O.
Sphynx 281 7 0.0053 0.003 0, 0075 0.8739 0.0047 0.0327 0 ,0077 0.0021 00320.0066 0.0031 0.002 0.0091 0.0034 0.0016 0.0041 0.002 0.0112 0.0023 0.0058 O.
Sphynx 282 7 0.0035 0.002 0, 0022 0.9577 0.001 0.002 0 ,002 0.002 00220.002 0.0021 0.0066 0.002 0.001 0.001 0.001 0.001 0.0021 0.002 0.0023 O.
Sphynx 283 10 0.0587 0.0023 0, 0041 0.8182 0.002 0.0043 0 ,003 0.0705 0021 0.0047 0.0028 0.0038 0.0029 0.0012 0.0013 0.001 0.003 0.001 0.0054 0.0065 O.
Sphynx 284 7 0.0037 0.0155 0, 0104 0.8288 0.0012 0.0083 0 ,002 0.0068 04460.0094 0.0372 0.0028 0.0026 0.0025 0.0021 0.0052 0.005 0.0027 0.002 0.0046 O.
Sphynx 285 7 0.0025 0.0021 0, 0032 0.9417 0.0033 0.002 0 ,0033 0.002 003 0.0026 0.0026 0.0029 0.003 0.0024 0.0022 0.0052 0.0031 0.0026 0.0037 0.0039 O.
Sphynx 286 7 0.003 0.0029 0. 002 0.9484 0.0012 0.002 0 ,0019 0.0041 003 0.002 0.0029 0.0056 0.0015 0.0016 0.001 0.001 0.0034 0.0039 0.0014 0.005 O.
Sphynx 287 10 0.0259 0.0163 0. 105 0.7 0.0097 0.0042 0 ,0056 0.0048 00320.008 0.0115 0.0318 0.0102 0.0038 0.0026 0.0029 0.0042 0.0082 0.017 0.0108 O.
Sphynx 288 7 0.0022 0.0091 0, 0029 0.9489 0.001 0.0134 0 ,002 0.0012 00290.002 0.002 0.001 0.003 0.0011 0.001 0.0011 0.0011 0.001 0.001 0.0011 O.
Sphynx 289 7 0.0037 0.016 0, 0053 0.8831 0.001 0.0029 0 ,0018 0.0058 03160.0034 0.0063 0.0099 0.0059 0.0044 0.0034 0.0027 0.0027 0.0013 0.001 0.0062 O.
Sphynx 290 10 0.0031 0.0028 0, 0035 0.9513 0.0028 0.0029 0 ,001 0.003 00140.002 0.0034 0.0013 0.004 0.0019 0.0027 0.0054 0.001 0.0025 0.0013 0.0017 O.
Sphynx 291 5 0.0053 0.0147 0, 0173 0.874 0.0046 0.0072 0 ,0021 0.0106 00230.008 0.0075 0.0039 0.0118 0.0045 0.0041 0.0027 0.005 0.0033 0.0015 0.0077 O.
Sphynx 292 5 0.0054 0.0035 0, 0023 0.9266 0.0011 0.0055 0 ,0039 0.0044 00380.002 0.0028 0.002 0.004 0.0027 0.0013 0.0021 0.001 0.0091 0.002 0.0043 O.
Sphynx 293 7 0.0018 0.0061 0. 0076 0.7433 0.0061 0.0041 0 ,031 0.004 022 0.0235 0.032 0.0083 0.0036 0.0166 0.0232 0.0185 0.0062 0.0089 0.0057 0.0084 O.
Japanese BT 1949 7 0.0029 0.0019 0, 0026 0.003 0.9335 0.0031 0 ,0013 0.0058 00130.0087 0.0043 0.0017 0.0105 0.0044 0.003 0.0025 0.001 0.001 0.0022 0.0038 O.
Japanese BT 1966 10 0.0131 0.0107 0, 0875 0.0202 0.7777 0.0023 0 ,002 0.0071 00590.0106 0.0152 0.0183 0.0034 0.0023 0.0021 0.002 0.0037 0.0015 0.0013 0.0055 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Japanese BT 2661 10 0.001 0.001 0, 001 0.001 0.9798 0.001 ,0011 0.001 001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0. Japanese BT 2663 5 0.001 0.0012 0, 001 0.001 0.9745 0.001 ,002 0.001 00190.001 0.001 0.002 0.0017 0.0013 0.001 0.0011 0.002 0.001 0.001 0.001 0. Japanese BT 2666 7 0.0029 0.0063 0, 0089 0.0055 0.8864 0.011 ,0132 0.002 0, 0021 0.0092 0.003 0.0023 0.0029 0.0016 0.0029 0.0028 0.0075 0.0047 0.0147 0.0056 0. Japanese BT 2668 10 0.0016 0.0042 0. 0156 0.0024 0.8897 0.003 ,0035 0.0029 0, 00460.0047 0.0211 0.003 0.0027 0.0031 0.002 0.0076 0.002 0.0066 0.0032 0.0034 0. Japanese BT 2973 13 0.0019 0.0023 0. 0044 0.002 0.9499 0.0024 0 ,0018 0.0013 0, 00330.002 0.004 0.002 0.005 0.003 0.0018 0.0025 0.002 0.001 0.0017 0.0024 O. Japanese BT 3324 10 0.0031 0.002 0, 0017 0.001 0.9731 0.001 0 ,0019 0.001 001 0.001 0.001 0.001 0.001 0.001 0.0019 0.001 0.001 0.001 0.001 0.0016 O. Japanese BT 3355 5 0.002 0.0031 0, 0017 0.001 0.9594 0.0011 0 ,003 0.0021 00370.002 0.002 0.001 0.0011 0.0021 0.001 0.0024 0.001 0.0023 0.0018 0.0042 O. Japanese BT 3356 15 0.0047 0.0174 0, 003 0.006 0.8809 0.0049 0 ,009 0.011 003 0.0057 0.0062 0.002 0.0283 0.0019 0.002 0.0055 0.002 0.0012 0.0013 0.003 0. Japanese BT 3523 7 0.0016 0.0048 0, 0049 0.002 0.9443 0.002 0 ,003 0.002 00550.002 0.0038 0.004 0.0029 0.0027 0.0026 0.0028 0.002 0.002 0.001 0.0021 0. Japanese BT 3621 7 0.0044 0.002 0, 0023 0.001 0.9505 0.002 0 ,0039 0.0012 0, 003 0.001 0.002 0.001 0.002 0.0025 0.0038 0.0094 0.003 0.001 0.0011 0.0019 O. Japanese BT 3622 10 0.0076 0.0035 0. 0043 0.004 0.802 0.002 0 ,005 0.0432 0, 01250.0094 0.008 0.002 0.0045 0.0052 0.002 0.0022 0.0258 0.0186 0.0026 0.0319 O. Japanese BT 3673 5 0.0019 0.003 0, 0037 0.0017 0.6722 0.0041 0 ,0031 0.0102 0, 2051 0.0117 0.0084 0.002 0.0148 0.0058 0.0023 0.029 0.0054 0.0068 0.0021 0.0025 O. Japanese BT 3691 5 0.0039 0.0031 0, 003 0.002 0.9432 0.001 0 ,0049 0.001 00480.002 0.0015 0.001 0.001 0.0011 0.0018 0.0022 0.0039 0.0026 0.007 0.0031 O. Japanese BT 3693 5 0.0018 0.0013 0, 0024 0.001 0.9627 0.0015 0 ,0027 0.001 003 0.003 0.002 0.002 0.001 0.0019 0.0028 0.0012 0.0015 0.0013 0.002 0.0026 O. Japanese BT 4027 13 0.0051 0.0289 0, 0052 0.0014 0.8401 0.0024 0 ,0142 0.004 00430.0082 0.0089 0.001 0.0113 0.0017 0.0015 0.0018 0.0481 0.0013 0.004 0.0035 O. Japanese BT 4030 13 0.0031 0.0038 0, 0025 0.0157 0.876 0.0089 0 ,0058 0.002 00360.003 0.005 0.0063 0.0088 0.0039 0.0038 0.0265 0.003 0.006 0.006 0.0036 O. Japanese BT 4043 10 0.0066 0.004 0. 0074 0.0104 0.7678 0.0309 0 ,086 0.0065 0, 00740.0043 0.0052 0.0025 0.004 0.002 0.0021 0.0037 0.01 0.0051 0.0026 0.0042 O. Cornish Rex 2497 7 0.0019 0.0042 0. 0039 0.002 0.001 0.933 0 ,002 0.002 0, 0011 0.002 0.0064 0.0023 0.002 0.0019 0.0019 0.002 0.001 0.0051 0.0122 0.002 O. Cornish Rex 2863 0 0.002 0.001 0, 0017 0.003 0.0036 0.954 0 ,0021 0.002 00720.001 0.001 0.001 0.001 0.0019 0.001 0.0012 0.001 0.0045 0.001 0.0042 O. Cornish Rex 2872 13 0.001 0.0018 0, 002 0.0013 0.001 0.9531 0 ,002 0.001 00250.002 0.002 0.001 0.002 0.0014 0.0019 0.002 0.001 0.0057 0.0056 0.0019 O. Cornish Rex 3283 2 0.0026 0.0026 0, 005 0.004 0.0123 0.8988 0 ,002 0.003 00430.002 0.0022 0.002 0.0021 0.0029 0.0024 0.0034 0.0035 0.0307 0.0047 0.0058 O. Cornish Rex 3306 15 0.0018 0.0034 0, 0023 0.0024 0.002 0.8649 0 ,0177 0.002 00420.011 0.0053 0.002 0.0057 0.0037 0.0084 0.0069 0.0047 0.0077 0.0116 0.0093 O. Cornish Rex 3931 10 0.001 0.0014 0, 0016 0.002 0.0032 0.9654 0 ,0013 0.002 ,0011 0.0031 0.0026 0.001 0.002 0.0012 0.002 0.0012 0.002 0.0018 0.001 0.0014 O. Cornish Rex 3955 7 0.0151 0.0186 0. 0076 0.0022 0.001 0.889 0 ,0191 0.0021 ,0019 0.0052 0.0099 0.0023 0.0059 0.0033 0.0021 0.0022 0.0016 0.0026 0.0025 0.0041 O. Cornish Rex 3992 23 0.0181 0.0022 0, 0042 0.0013 0.002 0.9222 0 ,002 0.0035 0, ,0067 0.0034 0.0027 0.001 0.0023 0.002 0.001 0.0032 0.002 0.004 0.0033 0.0107 O. Cornish Rex 5790 2 0.018 0.0106 0, 0146 0.0067 0.1444 0.7143 0 ,0035 0.0063 0, ,0108 0.0043 0.0234 0.0069 0.0054 0.0041 0.0033 0.002 0.0019 0.0024 0.0047 0.0084 O. Cornish Rex 7031 0 0.0023 0.0142 0, 0032 0.0111 0.0061 0.8151 0 ,003 0.0027 0, ,0023 0.0052 0.004 0.0167 0.0046 0.0131 0.0199 0.0166 0.0019 0.0341 0.0036 0.0173 O. Cornish Rex 7036 0 0.0036 0.0023 0, 0029 0.002 0.002 0.8666 0 ,0164 0.001 0, ,0031 0.0033 0.003 0.0011 0.002 0.002 0.0027 0.0034 0.0241 0.0043 0.0048 0.0034 O. Cornish Rex 8528 18 0.001 0.001 0, 002 0.002 0.0022 0.9638 0 ,002 0.0026 0, ,0013 0.002 0.0022 0.002 0.001 0.001 0.001 0.0016 0.0023 0.0026 0.0021 0.0028 O. Cornish Rex 8529 2 0.0018 0.002 0. 0018 0.0019 0.001 0.9633 0 ,002 0.002 0, ,001 0.002 0.0026 0.0019 0.002 0.001 0.001 0.0011 0.001 0.0017 0.0013 0.0014 O. Cornish Rex 8530 0 0.0012 0.0026 0. 0013 0.0011 0.0017 0.9591 0 ,0021 0.002 0.0064 0.001 0.003 0.001 0.0028 0.0016 0.001 0.0012 0.001 0.0031 0.002 0.0021 O. Cornish Rex 8543 5 0.001 0.0018 0, 0071 0.002 0.001 0.9612 0 ,001 0.002 0.0022 0.002 0.0026 0.002 0.0022 0.0021 0.0015 0.001 0.002 0.001 0.001 0.0016 O. Ragdoll 7429 5 0.002 0.0036 0, 0045 0.002 0.0022 0.0042 0 ,9378 0.001 0.001 0.0063 0.0026 0.002 0.0021 0.0042 0.002 0.0052 0.0082 0.0023 0.002 0.0033 O. Ragdoll 8362 2 0.0118 0.0024 0, 0051 0.0012 0.003 0.003 0 9272 0.002 0.0081 0.003 0.0028 0.002 0.0025 0.0017 0.0019 0.0028 0.0106 0.001 0.003 0.0029 O. Ragdoll 8366 0 0.0018 0.002 0, 0026 0.0015 0.004 0.002 0 ,9558 0.002 0.0022 0.0047 0.0025 0.001 0.0022 0.0014 0.002 0.0015 0.001 0.0023 0.002 0.0021 O. Ragdoll 8367 5 0.0208 0.0035 0, 004 0.0029 0.0018 0.0017 0 ,921 0.0069 0, 0048 0.0031 0.0027 0.0049 0.0045 0.0011 0.0021 0.0025 0.002 0.002 0.0025 0.0028 O. Ragdoll 8368 7 0.0044 0.001 0. 0027 0.002 0.0027 0.0013 0 ,9534 0.002 0, 002 0.002 0.0021 0.002 0.0019 0.0012 0.0014 0.002 0.003 0.004 0.0024 0.0025 O. Ragdoll 8372 13 0.425 0.0027 0, 0023 0.0037 0.0052 0.0051 0 ,5111 0.0031 0.0031 0.002 0.0024 0.003 0.003 0.0021 0.0016 0.0013 0.003 0.003 0.0087 0.0049 O. Ragdoll 8377 0 0.001 0.001 0, 001 0.0012 0.002 0.002 0 ,9636 0.001 0.0011 0.0011 0.0013 0.002 0.001 0.002 0.002 0.0029 0.002 0.004 0.0042 0.0018 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Ragdoll 9292 0 0.0151 0.0038 0, 0055 0.0021 0.001 0.0125 0 ,8937 0.0086 0, 0041 0.0035 0.0029 0.002 0.0086 0.0023 0.001 0.0024 0.0052 0.0033 0.0027 0.0057 0. Ragdoll 9295 5 0.004 0.002 0, 0024 0.0066 0.007 0.004 0 ,8912 0.001 0, 0121 0.002 0.0106 0.002 0.0029 0.0032 0.0032 0.0077 0.0052 0.0191 0.0044 0.0052 0. Ragdoll 9299 0 0.0091 0.0038 0, 0301 0.0093 0.0069 0.0026 0 ,666 0.0273 0, 0051 0.0123 0.0978 0.0147 0.0223 0.0045 0.0028 0.0134 0.0117 0.0056 0.0232 0.0151 0. Ragdoll 9300 10 0.0019 0.0022 0.0059 0.003 0.002 0.0047 0 ,9335 0.002 00540.0035 0.0051 0.001 0.0027 0.0097 0.0014 0.0011 0.002 0.0027 0.003 0.0049 0. Ragdoll 9301 2 0.0056 0.0033 0.0153 0.0024 0.0039 0.0034 0 ,9086 0.003 00590.0061 0.0064 0.001 0.0031 0.0034 0.0015 0.0033 0.0055 0.004 0.0073 0.0031 O. Ragdoll 9302 2 0.0049 0.0027 0, 0041 0.003 0.0021 0.0052 0 ,9162 0.0081 00720.0053 0.0083 0.0082 0.0051 0.0021 0.0034 0.0022 0.002 0.002 0.0032 0.0029 O. Ragdoll 9304 10 0.0037 0.0046 0, 0049 0.0078 0.003 0.0161 0 ,9128 0.0031 0011 0.0021 0.0018 0.0042 0.003 0.0019 0.0019 0.0034 0.0097 0.0051 0.002 0.0058 O. Ragdoll 9305 0 0.003 0.003 0, 0023 0.0065 0.001 0.001 0 ,9288 0.003 002 0.002 0.0028 0.001 0.001 0.0015 0.0056 0.0016 0.001 0.0029 0.0249 0.0025 O. Maine Coon 2950 5 0.002 0.0026 0, 0073 0.0039 0.002 0.0028 0 ,002 0.942 00490.0047 0.0045 0.003 0.005 0.0021 0.0026 0.0013 0.0013 0.001 0.0015 0.0019 O. Maine Coon 2959 13 0.0039 0.0083 0, 0084 0.0024 0.0019 0.0079 0 ,0134 0.8793 0, 00850.0044 0.0056 0.0087 0.0075 0.0062 0.0033 0.0028 0.0059 0.0045 0.0044 0.0052 O. Maine Coon 3304 18 0.0123 0.0104 0.0435 0.0023 0.0012 0.0072 0 ,0818 0.7136 0, 002 0.003 0.0795 0.003 0.0031 0.0028 0.0028 0.003 0.0077 0.0013 0.001 0.0175 O. Maine Coon 3311 5 0.0016 0.002 0, 0033 0.002 0.001 0.0029 0 ,002 0.9501 0, 002 0.002 0.0055 0.0022 0.0022 0.0034 0.001 0.0014 0.001 0.0034 0.0013 0.0065 O. Maine Coon 3495 13 0.0047 0.0044 0, 0098 0.003 0.0113 0.0025 0 ,0021 0.8838 0, 0011 0.0174 0.0195 0.0028 0.0133 0.0019 0.0067 0.002 0.0043 0.0027 0.001 0.0029 O. Maine Coon 3925 13 0.0072 0.0089 0, 0029 0.002 0.0042 0.0031 0 ,001 0.9303 0, 00350.002 0.0043 0.0031 0.0026 0.0099 0.0019 0.0028 0.001 0.0017 0.0019 0.004 O. Maine Coon 3941 5 0.0045 0.0025 0, 0062 0.0028 0.0056 0.0081 0 ,0054 0.9368 0, 00180.0039 0.0037 0.002 0.003 0.0018 0.0022 0.0029 0.0012 0.001 0.0013 0.0024 O. Maine Coon 9198 10 0.0043 0.0159 0, 0367 0.0081 0.0045 0.01 0 ,0249 0.3824 0, 0031 0.0077 0.0072 0.0114 0.1519 0.0039 0.0108 0.0067 0.0185 0.092 0.003 0.1198 O. Maine Coon 9775 7 0.0048 0.0014 0.0023 0.002 0.002 0.0036 0 ,0011 0.9566 0, 00150.002 0.0026 0.0045 0.0029 0.0014 0.0012 0.0021 0.002 0.0017 0.0014 0.0019 O. Maine Coon 10662 13 0.002 0.0027 0.0026 0.001 0.0019 0.0031 0 ,0019 0.9558 0, 0031 0.002 0.0025 0.002 0.002 0.0026 0.001 0.001 0.0045 0.0022 0.0023 0.0025 O. Maine Coon 11544 13 0.0058 0.0036 0, 0023 0.0066 0.0053 0.0094 0 ,002 0.916 0, 00580.0106 0.0081 0.0052 0.003 0.0028 0.0015 0.0021 0.003 0.0012 0.002 0.0027 O. Maine Coon 217 7 0.0066 0.0018 0, 0021 0.002 0.002 0.002 0 ,002 0.9577 0, 00560.002 0.0023 0.001 0.0019 0.001 0.0011 0.0012 0.002 0.001 0.001 0.002 O. Maine Coon 218 5 0.1421 0.0922 0, 0719 0.0067 0.0047 0.0057 0 ,217 0.0225 0, 02170.0049 0.098 0.0076 0.0157 0.0047 0.0046 0.0046 0.1483 0.0197 0.0119 0.0844 O. Maine Coon 219 7 0.006 0.001 0, 0012 0.002 0.001 0.001 0 ,002 0.9616 0, 00240.002 0.0021 0.002 0.002 0.0017 0.0029 0.0011 0.002 0.001 0.0013 0.0027 O. Maine Coon 220 7 0.0054 0.0141 0, 0185 0.0091 0.5015 0.2302 0 ,002 0.1042 0, 00580.0231 0.0309 0.004 0.004 0.0032 0.002 0.0036 0.0138 0.0065 0.0032 0.0089 O. Maine Coon 221 5 0.0073 0.0104 0.0101 0.0065 0.002 0.0168 0 ,0038 0.879 0, 00180.0092 0.012 0.0069 0.0088 0.002 0.0058 0.0033 0.0048 0.0014 0.0013 0.0058 O. Maine Coon 222 5 0.0057 0.3721 0, 0464 0.0217 0.0032 0.0192 0 ,0066 0.3519 0, 00430.0456 0.0454 0.0093 0.0131 0.0077 0.0046 0.0091 0.001 0.0043 0.002 0.0242 O. Maine Coon 223 5 0.0066 0.0196 0, 0285 0.0141 0.003 0.0256 0 ,0156 0.7372 0, 05480.0153 0.0317 0.007 0.0055 0.005 0.0023 0.0084 0.0053 0.0011 0.0012 0.0097 O. Maine Coon 224 5 0.0058 0.0033 0, 0146 0.0027 0.0109 0.0052 0 ,146 0.6608 0, 01170.0106 0.018 0.0119 0.0199 0.0029 0.0012 0.0043 0.0028 0.019 0.0091 0.0206 O. Abyssinian 110 5 0.0022 0.0066 0, 0073 0.0065 0.0053 0.0065 0 ,0021 0.0057 0, 77170.0041 0.0038 0.002 0.0031 0.0022 0.0021 0.0848 0.0683 0.0017 0.0011 0.0027 O. Abyssinian 111 7 0.0035 0.0067 0, 0073 0.0099 0.007 0.0362 0 ,002 0.0115 0, 749 0.008 0.0267 0.0108 0.0087 0.0037 0.0012 0.0881 0.001 0.0052 0.0034 0.0059 O. Abyssinian 112 7 0.0015 0.0011 0.0015 0.0011 0.0011 0.0015 0 ,0011 0.0013 0, 87290.0021 0.0046 0.002 0.0011 0.0015 0.0011 0.0952 0.004 0.0012 0.0011 0.0015 O. Abyssinian 113 7 0.003 0.0095 0.0062 0.007 0.002 0.0034 0 ,0014 0.0037 0, 7841 0.0086 0.0208 0.0026 0.0655 0.0037 0.0015 0.0681 0.001 0.0014 0.0011 0.0042 O. Abyssinian 114 5 0.0015 0.0021 0, 0015 0.0024 0.001 0.0023 0 ,0021 0.0017 0, 87630.002 0.0019 0.0011 0.0011 0.002 0.0015 0.092 0.0011 0.0014 0.0011 0.0026 O. Abyssinian 115 5 0.0018 0.0018 0, 0039 0.001 0.0018 0.0041 0 ,0013 0.0023 0, 8641 0.0021 0.0021 0.001 0.0034 0.0016 0.0023 0.0957 0.0013 0.001 0.001 0.0025 O. Abyssinian 116 5 0.0011 0.0011 0, 0012 0.0012 0.001 0.001 0 ,0036 0.001 87860.001 0.0013 0.0011 0.0018 0.0014 0.001 0.0953 0.001 0.0011 0.0014 0.001 O. Abyssinian 117 5 0.001 0.001 0, 0013 0.0154 0.001 0.0011 0 ,0019 0.0011 87190.001 0.0019 0.0032 0.001 0.001 0.001 0.0878 0.0011 0.0018 0.0017 0.0013 O. Abyssinian 118 7 0.0011 0.0011 0, 0011 0.0022 0.0011 0.001 0 ,0021 0.0016 0, 88170.0014 0.0013 0.001 0.0012 0.0014 0.001 0.0893 0.001 0.0025 0.0023 0.0018 O. Abyssinian 119 7 0.0021 0.0051 0.0017 0.0069 0.0016 0.0019 0 ,013 0.0033 0, 8471 0.0021 0.0033 0.0011 0.0053 0.0018 0.001 0.0912 0.001 0.0047 0.0016 0.0024 O. Abyssinian 120 5 0.0017 0.0025 0, 0024 0.001 0.0013 0.002 0 ,0017 0.0011 0, ,87230.001 0.0012 0.002 0.002 0.002 0.001 0.0978 0.0011 0.0011 0.0015 0.0015 O. Abyssinian 121 5 0.002 0.0022 0, 0032 0.0022 0.0021 0.0011 0.0011 0.0022 0.84660.002 0.004 0.0021 0.0031 0.0021 0.0032 0.0961 0.0022 0.0021 0.0066 0.0033 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Abyssinian 122 7 0.0021 0.001 001 0.001 0.001 0.001 0 ,002 0.001 86360.001 0.002 0.0027 0.001 0.001 0.0014 0.0944 0.0017 0.0039 0.001 0.0014 0. Abyssinian 123 5 0.0011 0.001 0013 0.0013 0.0016 0.001 0 ,0024 0.0022 86920.0032 0.0017 0.0021 0.003 0.0013 0.0067 0.0929 0.0012 0.0023 0.0017 0.0016 0. Abyssinian 6934 28 0.0051 0.0051 0039 0.0011 0.0013 0.0024 0 ,0048 0.0019 749 0.0023 0.002 0.003 0.0021 0.0023 0.0034 0.0831 0.0949 0.0046 0.0011 0.0033 0.
Siberi lan 3273 21 0.0042 0.0092 0 012 0.0037 0.0059 0.002 0 ,002 0.0059 00940.8101 0.0 3 0.0041 0.0246 0.0635 0.0044 0.0047 0.002 0.002 0.0045 0.0132 0. Siberi ian 4593 21 0.003 0.0049 0049 0.0028 0.0062 0.0025 0 ,0022 0.004 00260.9239 0.0109 0.0025 0.002 0.002 0.0109 0.0025 0.004 0.002 0.0025 0.002 O. Siberi ian 4829 7 0.002 0.003 O 0037 0.0053 0.003 0.002 ,003 0.0154 00330.9021 0.0146 0.002 0.0049 0.0023 0.0055 0.0047 0.0111 0.0025 0.0028 0.0044 O. Siberi ian 4928 5 0.3394 0.007 0064 0.0022 0.001 0.001 ,0018 0.0062 001 0.5831 0.0044 0.0016 0.0032 0.0015 0.0019 0.0018 0.0022 0.0022 0.002 0.028 O. Siberi ian 4930 7 0.0032 0.0153 0025 0.0018 0.0017 0.001 ,0031 0.002 0011 0.8832 0.0028 0.0029 0.0022 0.0145 0.0107 0.002 0.0414 0.002 0.0022 0.0034 O. Siberi ian 5101 13 0.0051 0.0033 0024 0.0011 0.001 0.001 ,0029 0.0034 002 0.9575 0.0021 0.0018 0.0019 0.0019 0.0018 0.0025 0.0026 0.001 0.001 0.0027 O. Siberi ian 5105 15 0.0036 0.0023 0054 0.002 0.0055 0.0065 0 ,0133 0.0023 00240.8245 0.003 0.0289 0.0061 0.0679 0.0054 0.0029 0.0015 0.0017 0.0022 0.011 O. Siberi ian 5107 5 0.0091 0.0067 0. 0403 0.0062 0.0122 0.0739 0 .003 0.0039 00370.7549 0.0113 0.0081 0.0072 0.0144 0.0019 0.0028 0.002 0.003 0.0176 0.0102 O. Siberi ian 5110 10 0.0022 0.0027 O 0054 0.0117 0.0359 0.002 0 ,002 0.3551 002 0.5514 0.0041 0.002 0.0064 0.0021 0.002 0.0029 0.0012 0.003 0.0017 0.0027 O. Siberi ian 5118 7 0.0025 0.003 0082 0.0064 0.002 0.002 0 ,0073 0.0021 0051 0.8052 0.0533 0.0069 0.0053 0.0108 0.0089 0.0018 0.0283 0.0289 0.001 0.0061 O. Siberi ian 5120 5 0.002 0.0029 0047 0.003 0.0039 0.0098 0 ,0037 0.0054 0021 0.8584 0.0526 0.0091 0.0038 0.0031 0.0034 0.0046 0.0093 0.0086 0.002 0.0038 O. Siberi ian 5632 5 0.0368 0.0162 0087 0.004 0.0059 0.0046 0 ,0058 0.0779 00630.6382 0.0097 0.0329 0.0047 0.0024 0.002 0.0014 0.0044 0.013 0.0262 0.0077 O. Siberi ian 6474 5 0.0032 0.0037 0026 0.0028 0.0894 0.0059 0 ,0162 0.0028 002 0.8405 0.0036 0.001 0.0049 0.0036 0.0052 0.0014 0.0018 0.0013 0.0026 0.0032 O. Siberi ian 11562 15 0.0049 0.0091 0 0381 0.0061 0.002 0.0022 0 ,0133 0.0083 01750.7766 0.0398 0.003 0.0139 0.0059 0.0045 0.0045 0.0042 0.0053 0.0241 0.0111 O. Siberi ian 11582 10 0.046 0.0051 0074 0.0069 0.0093 0.0043 0 ,0118 0.0204 0271 0.6859 0.0968 0.0251 0.0024 0.007 0.0081 0.0135 0.002 0.0037 0.001 0.0143 O. Siberi ian 11559 13 0.0042 0.0046 O 0048 0.002 0.0037 0.0099 0 ,0052 0.004 01030.9102 0.0105 0.002 0.003 0.0024 0.0011 0.0022 0.0072 0.0053 0.0017 0.0034 O. Siberi ian 11560 13 0.0116 0.0096 0087 0.0067 0.0032 0.0029 0 ,0214 0.02 00170.7299 0.0303 0.0089 0.0802 0.0048 0.0318 0.0051 0.002 0.0012 0.0044 0.0119 O.
Norwegian FC 2942 15 0.0076 0.0048 0046 0.0052 0.0067 0.002 0.002 0.0062 00180.0224 0.8878 0.0251 0.0036 0.0019 0.0011 0.0029 0.002 0.0044 0.0027 0.003 O. Norwegian FC 3610 47 0.0083 0.1843 0307 0.0031 0.0046 0.0042 0 ,0038 0.0375 0041 0.0255 0.4997 0.0725 0.039 0.0189 0.0113 0.0038 0.0215 0.002 0.0047 0.0153 O. Norwegian FC 3611 13 0.2644 0.01 0142 0.0029 0.0031 0.0204 0 ,0076 0.3742 01460.0658 0.1256 0.0018 0.0073 0.0107 0.002 0.0014 0.0062 0.0022 0.002 0.0615 O. Norwegian FC 3612 7 0.003 0.004 0. 0019 0.0025 0.0033 0.0052 0 ,0025 0.004 00190.021 0.9191 0.0078 0.0027 0.0029 0.0032 0.0025 0.0032 0.002 0.0017 0.0027 O. Norwegian FC 3617 26 0.0042 0.0107 O 0124 0.0084 0.0027 0.003 0 ,0032 0.019 0021 0.8151 0.0663 0.0106 0.009 0.0035 0.006 0.0063 0.0031 0.004 0.002 0.0059 O. Norwegian FC 3661 31 0.0053 0.0473 O 015 0.002 0.0033 0.0035 0 ,0052 0.0054 01320.0095 0.8189 0.0045 0.0037 0.0078 0.0095 0.0036 0.0061 0.0157 0.002 0.0146 O. Norwegian FC 4815 7 0.0033 0.013 0766 0.0174 0.0043 0.0119 0 ,0151 0.026 00920.027 0.6794 0.0062 0.007 0.0066 0.0021 0.004 0.004 0.0047 0.0034 0.0552 O. Norwegian FC 4816 2 0.0021 0.0027 0257 0.0011 0.002 0.0021 0 ,0059 0.0182 00830.0068 0.8951 0.0039 0.0023 0.0016 0.0031 0.0023 0.001 0.0016 0.001 0.0119 O. Norwegian FC 6004 18 0.0049 0.0053 0183 0.0089 0.0046 0.0152 0 ,0065 0.0154 0021 0.0161 0.7258 0.0282 0.0522 0.0683 0.0038 0.0023 0.001 0.0027 0.0017 0.0148 O. Norwegian FC 6932 44 0.007 0.0029 0 0041 0.0092 0.0036 0.0061 0 ,0079 0.0048 00270.0141 0.6163 0.0163 0.0076 0.0032 0.0154 0.0039 0.2592 0.0062 0.003 0.0039 O. Norwegian FC 9321 2 0.0029 0.0426 0147 0.0145 0.0087 0.0042 0 ,0191 0.622 00330.0099 0.1254 0.0072 0.0961 0.0046 0.0021 0.0033 0.0105 0.0013 0.001 0.0052 O. Norwegian FC 10367 34 0.0079 0.0132 O 0173 0.0076 0.0031 0.0138 0 ,0068 0.0053 0111 0.1797 0.6539 0.0315 0.0076 0.0032 0.0026 0.0047 0.0128 0.006 0.0022 0.0073 O. Norwegian FC 10682 13 0.0094 0.0036 0049 0.005 0.0609 0.0034 0 ,0029 0.0096 00350.0196 0.8214 0.0143 0.0082 0.0058 0.0051 0.0049 0.0069 0.0024 0.0023 0.0048 O. Norwegian FC 11548 18 0.0086 0.0763 1058 0.0041 0.002 0.0076 0 ,0044 0.0129 00390.0455 0.5909 0.0508 0.0351 0.002 0.0139 0.0136 0.0038 0.0051 0.0057 0.0053 O. Norwegian FC 242 7 0.0031 0.2604 0126 0.0044 0.001 0.0032 0 ,0084 0.0433 05050.0706 0.476 0.0048 0.0065 0.0211 0.0038 0.0046 0.002 0.0064 0.0022 0.0095 O. Manx 2928 15 0.0049 0.0053 1084 0.0037 0.002 0.0123 0 ,002 0.1142 00650.0166 0.6578 0.0049 0.0038 0.0021 0.0019 0.0021 0.0034 0.0017 0.001 0.0436 O. Manx 2980 31 0.0048 0.0083 0. 2651 0.0023 0.0078 0.002 0 ,0176 0.0103 01890.0232 0.5133 0.0093 0.0045 0.0063 0.0033 0.003 0.002 0.0013 0.0015 0.0934 O. Manx 3926 10 0.0027 0.0036 O 2563 0.0021 0.003 0.0061 0 ,0035 0.0053 00580.0035 0.56 0.0398 0.005 0.0036 0.0022 0.0019 0.001 0.002 0.0023 0.089 O. Manx 4378 0 0.0121 0.1224 1639 0.0065 0.0039 0.0208 0 ,0076 0.0326 00590.004 0.5237 0.0074 0.0033 0.0033 0.0021 0.0032 0.0037 0.0013 0.0013 0.0694 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Manx 5757 2 0.0059 0.005 0, 1857 0.0032 0.0043 0.0118 0 ,002 0.2705 00230.0032 0.4171 0.0031 0.0031 0.0026 0.0031 0.0029 0.002 0.001 0.0045 0.0657 0. Manx 6294 5 0.3341 0.0022 0, 167 0.0036 0.002 0.0015 0 ,0122 0.0063 00350.008 0.326 0.0024 0.0111 0.0166 0.0022 0.0013 0.0014 0.0037 0.0013 0.0915 0. Manx 6296 10 0.0018 0.0074 0, 3603 0.0042 0.001 0.0205 0 ,0024 0.0061 00130.0101 0.4823 0.0022 0.0048 0.0033 0.001 0.0019 0.0035 0.0014 0.0017 0.0805 0. Manx 6299 5 0.0035 0.0163 0. 2518 0.0025 0.0054 0.022 0.003 0.0221 02870.0155 0.4937 0.0022 0.0133 0.0119 0.002 0.0021 0.001 0.002 0.001 0.0976 0. Manx 7079 5 0.0189 0.024 0. 2636 0.012 0.0049 0.0045 0 ,0104 0.0067 00440.0152 0.4918 0.0046 0.016 0.0023 0.0121 0.0055 0.0138 0.0019 0.0021 0.083 O. Manx 7082 5 0.0314 0.0239 0, 0066 0.0078 0.0035 0.0129 0 ,0131 0.0171 00630.0412 0.7496 0.0087 0.0085 0.0127 0.0099 0.0044 0.002 0.0041 0.0167 0.0117 O. Manx 7083 0 0.0021 0.017 0, 0032 0.0023 0.0163 0.003 0.009 0.0033 00550.0042 0.8929 0.0069 0.0026 0.0033 0.0026 0.0019 0.001 0.0021 0.0141 0.0032 O. Manx 7105 2 0.0048 0.0022 0, 2381 0.0086 0.0058 0.0161 0 ,0789 0.0026 00460.005 0.4752 0.0509 0.0089 0.0057 0.0019 0.0036 0.0019 0.0023 0.002 0.0786 O. Manx 7108 0 0.0227 0.0037 0, 2805 0.0108 0.002 0.0059 0 ,0071 0.0028 00190.0046 0.5445 0.0014 0.003 0.0011 0.0017 0.001 0.002 0.002 0.0031 0.0959 O. Manx 7112 2 0.0288 0.0056 0, 2782 0.0175 0.003 0.0084 0 ,0095 0.0027 00170.0041 0.5021 0.005 0.0176 0.0045 0.0045 0.0021 0.0019 0.0029 0.0034 0.0944 O. Manx 7708 5 0.2924 0.0192 0. 0126 0.0042 0.004 0.0047 0 ,0132 0.0132 00190.3028 0.0799 0.1553 0.0212 0.0114 0.0012 0.0095 0.0047 0.0013 0.002 0.044 O. Manx 9084 18 0.0062 0.0058 0, 281 0.0054 0.0037 0.0036 0 ,0042 0.0047 003 0.0035 0.5503 0.006 0.0057 0.0047 0.0031 0.0058 0.003 0.0023 0.002 0.0948 O. Manx 9091 7 0.0329 0.0101 0, 1494 0.005 0.008 0.0087 0 ,0031 0.0236 02350.0579 0.4568 0.0469 0.0832 0.0035 0.0028 0.0074 0.0112 0.0075 0.002 0.054 O.
Egypt an Mau 1812 5 0.0044 0.0029 0, 0036 0.0046 0.001 0.001 0 ,0033 0.0051 00520.002 0.0061 0.9301 0.0101 0.0034 0.0019 0.0029 0.001 0.0036 0.001 0.0051 O. Egypt an Mau 2431 18 0.0021 0.0029 0, 0025 0.0029 0.0062 0.0099 0 ,0016 0.0126 001 0.002 0.002 0.9326 0.003 0.002 0.0042 0.0034 0.001 0.0025 0.0017 0.0019 O. Egypt an Mau 2433 7 0.0011 0.0036 0, 0019 0.002 0.001 0.001 0 ,0073 0.001 001 0.0042 0.0024 0.8827 0.0033 0.003 0.0059 0.0628 0.0034 0.0035 0.002 0.0053 O. Egypt an Mau 3331 26 0.0029 0.0027 0. 0023 0.0067 0.0019 0.0162 0 ,012 0.0079 01140.003 0.003 0.8547 0.0038 0.0028 0.0026 0.0108 0.002 0.0347 0.0094 0.0044 O. Egypt an Mau 3332 15 0.001 0.0012 0. 0023 0.0016 0.002 0.002 0 ,0043 0.0041 001 0.0018 0.002 0.9613 0.0027 0.0024 0.002 0.0019 0.001 0.001 0.0015 0.0016 O. Egypt an Mau 5545 15 0.0049 0.0032 0, 0098 0.0026 0.0062 0.003 0 ,0011 0.004 002 0.0075 0.0047 0.9225 0.0034 0.0029 0.002 0.0055 0.004 0.003 0.0018 0.0033 O. Egypt an Mau 5553 15 0.0035 0.0052 0, 0065 0.0041 0.0244 0.0154 0 ,0023 0.0047 00290.002 0.0102 0.7988 0.011 0.0078 0.006 0.0782 0.001 0.0017 0.0104 0.0026 O. Egypt an Mau 5567 28 0.0077 0.0254 0, 0033 0.0044 0.0075 0.0033 0 ,0051 0.004 00330.005 0.0158 0.8821 0.0031 0.0032 0.0011 0.0052 0.0094 0.0027 0.0024 0.0043 O. Egypt an Mau 5568 28 0.002 0.0015 0, 0032 0.0041 0.0013 0.001 0 ,001 0.0019 00220.0019 0.0027 0.9561 0.0021 0.0032 0.0017 0.0023 0.003 0.0023 0.0019 0.003 O. Egypt an Mau 7475 13 0.0068 0.0013 0, 002 0.0021 0.001 0.002 0 ,001 0.0038 001 0.0011 0.002 0.9649 0.001 0.0011 0.0015 0.001 0.0012 0.001 0.001 0.0021 O. Egypt an Mau 7476 28 0.0094 0.0157 0. 0774 0.002 0.0636 0.002 0 ,002 0.0042 00350.0061 0.0122 0.6551 0.0265 0.0139 0.0072 0.0038 0.0019 0.0084 0.0683 0.0038 O. Egypt an Mau 7479 34 0.002 0.0011 0, 0013 0.0023 0.0034 0.0023 0 ,0056 0.0021 00170.002 0.002 0.7461 0.0014 0.0069 0.0015 0.0038 0.0114 0.0336 0.0062 0.0791 O. Egypt an Mau 7480 28 0.001 0.001 0, 0013 0.001 0.0025 0.002 0 ,001 0.001 001 0.001 0.0024 0.9743 0.002 0.0011 0.0011 0.001 0.001 0.001 0.001 0.0012 O. Egypt ian Mau 11410 13 0.017 0.0195 0, 0022 0.0197 0.0017 0.0352 0 ,0019 0.0184 00220.002 0.012 0.6149 0.0165 0.0033 0.0074 0.2079 0.0035 0.0033 0.0016 0.0088 O. Turk. Angora 607 15 0.0696 0.0333 0, 0401 0.0083 0.0253 0.0088 0 ,002 0.0285 03060.0681 0.0823 0.0252 0.4761 0.0349 0.0358 0.0037 0.0066 0.0036 0.0012 0.014 O. Turk. Angora 1832 13 0.0028 0.0025 0, 0024 0.0042 0.002 0.002 0 ,0026 0.0084 00420.0038 0.0072 0.0031 0.9312 0.003 0.0017 0.0059 0.002 0.0034 0.001 0.0036 O. Turk. Angora 1845 13 0.001 0.0013 0. 0017 0.001 0.0021 0.001 0 ,0021 0.0011 00190.0017 0.0024 0.0022 0.9687 0.0018 0.0011 0.0012 0.001 0.0018 0.002 0.0012 O. Turk. Angora 2848 18 0.0114 0.0719 0. 079 0.0184 0.0083 0.0574 0 ,0086 0.0169 0051 0.0042 0.0893 0.0319 0.497 0.0227 0.0027 0.0081 0.0031 0.0042 0.0055 0.0316 O. Turk. Angora 2862 21 0.0043 0.0023 0, 0039 0.002 0.0047 0.0023 0 ,0125 0.004 003 0.002 0.0026 0.0021 0.9333 0.0041 0.0035 0.0034 0.002 0.0017 0.0011 0.0024 O. Turk. Angora 5552 7 0.0031 0.003 0, 0073 0.0058 0.0059 0.0038 0 ,0057 0.0037 00470.0043 0.0025 0.0021 0.9191 0.0016 0.0033 0.0021 0.001 0.0064 0.0062 0.005 O. Turk. Angora 5563 5 0.0093 0.0014 0, 0046 0.005 0.0032 0.0073 0 ,0021 0.0071 00140.0021 0.0078 0.0054 0.9209 0.002 0.0048 0.005 0.0019 0.0013 0.0021 0.004 O. Turk. Angora 5564 5 0.0017 0.0089 0, 0119 0.0021 0.002 0.0271 0 ,0037 0.0037 02680.0534 0.0636 0.0066 0.7368 0.0048 0.0312 0.0047 0.001 0.001 0.001 0.0062 O. Turk. Angora 6350 10 0.0024 0.0046 0, 0036 0.0021 0.0121 0.0057 0 ,0022 0.0027 00270.0081 0.0045 0.0065 0.9169 0.0044 0.0059 0.0031 0.0015 0.0026 0.0033 0.003 O. Turk. Angora 9541 0 0.002 0.0055 0. 0082 0.0072 0.0041 0.0047 0 ,002 0.002 0021 0.421 0.0049 0.0106 0.3367 0.0118 0.1236 0.0329 0.0026 0.0049 0.0054 0.0048 O. Turk. Angora 9542 23 0.0017 0.0013 0, 0013 0.001 0.001 0.0017 0 ,0011 0.001 001 0.0011 0.0011 0.0016 0.0012 0.0023 0.879 0.0963 0.0011 0.0014 0.0012 0.0015 O. Turk. Angora 9584 10 0.0028 0.0478 0, 0107 0.0092 0.0732 0.002 0.0044 0.0064 02870.3881 0.0246 0.0044 0.2958 0.0504 0.0187 0.0063 0.0037 0.0028 0.0037 0.0135 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Turk. Angora 9586 2 0.0455 0.0084 0, 0233 0.0068 0.0122 0.014 0 ,051 0.0122 00540.0351 0.3795 0.0211 0.3065 0.0257 0.0029 0.0021 0.002 0.0027 0.0013 0.0336 0. Turk. Angora 9608 10 0.0033 0.005 0, 0146 0.003 0.0031 0.0021 0 ,0053 0.046 0101 0.0193 0.1131 0.003 0.1273 0.538 0.0019 0.0025 0.002 0.0068 0.0022 0.0839 0. Turk. Angora 9609 7 0.0045 0.0029 0, 0043 0.006 0.0045 0.0029 0 ,0091 0.0021 00290.0107 0.0044 0.0044 0.1047 0.6694 0.0581 0.0145 0.0011 0.0017 0.0028 0.0865 0. Turk. Angora 9610 13 0.0076 0.0104 0. 0027 0.0025 0.0057 0.004 0 ,0125 0.0035 01340.003 0.0037 0.0033 0.0947 0.7216 0.0017 0.0013 0.0046 0.003 0.0038 0.094 0. Turk. Angora 9611 5 0.0011 0.001 0. 0011 0.001 0.001 0.0011 0 ,0011 0.0011 0011 0.0011 0.001 0.0011 0.0964 0.7792 0.0073 0.0012 0.0011 0.0011 0.0011 0.0986 O. Turk. Angora 9612 5 0.002 0.0027 0, 0124 0.004 0.0035 0.003 0 ,002 0.2123 0041 0.0187 0.0084 0.0215 0.0823 0.5342 0.0026 0.0013 0.0049 0.0022 0.0019 0.0719 O. Turk. Angora 9613 2 0.005 0.0032 0, 0057 0.0076 0.0136 0.0065 0 ,0033 0.0332 01980.0056 0.0069 0.0551 0.7127 0.0029 0.006 0.0899 0.0015 0.0141 0.0017 0.0034 O. Turk. Angora 9614 2 0.0011 0.0011 0, 0011 0.001 0.0021 0.0032 0 ,0013 0.0017 001 0.0032 0.0023 0.0021 0.0961 0.7776 0.0017 0.0011 0.001 0.001 0.001 0.0983 O. Turk. Angora 9615 7 0.0021 0.0019 0, 0014 0.001 0.001 0.002 0 ,0023 0.0017 00190.0023 0.0022 0.0011 0.0948 0.7738 0.0027 0.0018 0.0019 0.0022 0.0014 0.0986 O. Turkish Van 1789 13 0.001 0.0012 0, 0015 0.001 0.0014 0.001 0 ,001 0.001 001 0.0011 0.0011 0.0015 0.0011 0.001 0.8809 0.0981 0.0011 0.001 0.001 0.001 O. Turkish Van 3013 18 0.0016 0.0045 0. 0087 0.0016 0.0024 0.0015 0 ,0014 0.0015 00130.0018 0.0052 0.0055 0.0045 0.004 0.8524 0.0948 0.0011 0.001 0.0011 0.0018 O. Turkish Van 3056 5 0.0025 0.0372 0, 0025 0.0105 0.0025 0.0042 0 ,001 0.0087 00630.0111 0.0133 0.002 0.0069 0.0031 0.771 0.0915 0.0038 0.0023 0.0135 0.0039 O. Turkish Van 4090 15 0.0022 0.0026 0, 003 0.0015 0.0023 0.0014 0 ,0024 0.0015 00260.0025 0.0025 0.0023 0.0016 0.0016 0.8667 0.0966 0.0015 0.0012 0.001 0.0014 O. Turkish Van 7662 21 0.0022 0.0035 0, 0033 0.0037 0.0021 0.0048 0 ,0029 0.002 00190.0045 0.0047 0.0036 0.0168 0.0301 0.8133 0.0742 0.0024 0.0129 0.0042 0.0049 O. Turkish Van 7663 34 0.0092 0.0231 0, 0065 0.0049 0.0072 0.0041 0 ,0054 0.0055 002 0.0076 0.0059 0.0047 0.0057 0.0249 0.6873 0.1447 0.0048 0.014 0.0094 0.0181 O. Turkish Van 7666 39 0.0076 0.0032 0, 0051 0.0033 0.0223 0.0011 0 ,0125 0.0028 00440.0045 0.0056 0.006 0.0047 0.003 0.7513 0.1171 0.002 0.0046 0.0287 0.0029 O. Turkish Van 7667 36 0.0034 0.0043 0. 0041 0.002 0.042 0.0078 0 ,0024 0.0091 00970.0734 0.006 0.0033 0.0059 0.0093 0.711 0.0879 0.0024 0.0052 0.0019 0.0065 O. Turkish Van 9322 5 0.0109 0.1919 0. 0066 0.0023 0.0019 0.0063 0 ,0054 0.0033 00170.0302 0.0053 0.0026 0.0106 0.0023 0.637 0.0605 0.0018 0.002 0.0112 0.0034 O. Turkish Van 9535 2 0.0042 0.0034 0, 0045 0.002 0.002 0.0015 0 ,001 0.0027 00180.0184 0.009 0.001 0.0036 0.0353 0.82 0.0761 0.0043 0.001 0.0013 0.0055 O. Turkish Van 9538 0 0.0036 0.0031 0, 0044 0.0038 0.0019 0.0025 0 ,0023 0.0024 00240.0034 0.0028 0.0072 0.0053 0.0039 0.8435 0.0946 0.0015 0.0036 0.0016 0.0023 O. Turkish Van 9539 0 0.0104 0.1031 0, 0312 0.0032 0.0022 0.0021 0 ,0024 0.0041 084 0.048 0.0133 0.0117 0.0116 0.0107 0.5446 0.0595 0.001 0.0027 0.0386 0.0129 O. Turkish Van 9543 0 0.0022 0.0077 0, 0183 0.0033 0.0059 0.0049 0 ,0387 0.0042 01 0.0855 0.0432 0.0042 0.6395 0.0083 0.0156 0.0709 0.0026 0.003 0.0132 0.0124 O. Turkish Van 9563 2 0.0225 0.0161 0, 0443 0.0118 0.0041 0.0062 0 ,0038 0.0162 00690.0116 0.0293 0.0145 0.0123 0.0084 0.5507 0.2153 0.0086 0.0033 0.0029 0.0096 O. Turkish Van 9564 2 0.0014 0.0052 0. 0095 0.0019 0.0042 0.0039 0 ,0068 0.0016 00170.0071 0.0026 0.0019 0.0057 0.0077 0.8296 0.1002 0.0017 0.001 0.001 0.003 O. Turkish Van 9573 0 0.002 0.0013 0, 0021 0.0014 0.0024 0.001 0 ,0017 0.0031 00340.0023 0.002 0.0024 0.0063 0.0022 0.8454 0.1118 0.001 0.0019 0.0028 0.0022 O. Turkish Van 9574 0 0.0021 0.003 0, 0047 0.009 0.002 0.0014 0 ,0039 0.002 00330.015 0.0052 0.0096 0.0072 0.1311 0.6738 0.0764 0.016 0.0076 0.003 0.0215 O. Turkish Van 9575 0 0.003 0.0013 0, 0211 0.005 0.0038 0.0081 0 ,0072 0.003 031 0.6143 0.0709 0.0073 0.0119 0.0115 0.1241 0.0357 0.0029 0.0085 0.0031 0.0143 O. Turkish Van 9576 2 0.002 0.0042 0, 0059 0.0148 0.1006 0.003 0 ,0149 0.002 05020.4899 0.0374 0.002 0.0777 0.0106 0.0205 0.0064 0.003 0.0757 0.0331 0.0073 O. Turkish Van 9581 5 0.0039 0.0038 0, 0051 0.0053 0.0049 0.0039 0 ,0112 0.0039 00640.691 0.0077 0.0048 0.0368 0.1393 0.0099 0.0068 0.0022 0.0165 0.0098 0.0252 O. Bengal 2518 52 0.0177 0.0044 0. 0067 0.004 0.0024 0.0037 0 ,012 0.0031 08250.0075 0.0068 0.0123 0.0438 0.0073 0.0124 0.7459 0.0019 0.0051 0.0044 0.008 O. Bengal 3455 44 0.002 0.0022 0. 0028 0.0023 0.0015 0.002 0 ,002 0.0021 00170.0026 0.002 0.002 0.0021 0.002 0.0288 0.9157 0.0049 0.0057 0.0086 0.0026 O. Bengal 3478 39 0.0017 0.0023 0, 0065 0.0046 0.001 0.0025 0 ,0023 0.0044 00350.003 0.0145 0.0785 0.011 0.0033 0.0126 0.8365 0.001 0.0027 0.0019 0.0042 O. Bengal 3522 18 0.0039 0.0072 0, 0059 0.0032 0.0034 0.0065 0 ,0112 0.006 033 0.0044 0.0201 0.0022 0.0069 0.0568 0.0019 0.8101 0.002 0.0016 0.0022 0.0078 O. Bengal 3541 18 0.0084 0.0028 0, 0054 0.0025 0.0038 0.0018 0 ,0171 0.0044 00190.0202 0.0034 0.0085 0.0025 0.0025 0.0015 0.9003 0.0048 0.0012 0.0011 0.0043 O. Bengal 3550 31 0.0011 0.0021 0, 003 0.0029 0.0022 0.0059 0 ,0048 0.0019 0051 0.0028 0.0029 0.0031 0.0102 0.0036 0.0023 0.9346 0.0011 0.0023 0.0025 0.0022 O. Bengal 6678 0 0.0011 0.0025 0, 0031 0.0042 0.0025 0.0019 0 ,0025 0.001 00690.0021 0.002 0.0069 0.0035 0.0033 0.0028 0.9321 0.0011 0.0099 0.0032 0.0057 O. Bengal 6899 0 0.0148 0.0024 0. 008 0.0091 0.0229 0.0988 0 ,009 0.012 01 0.004 0.0236 0.0024 0.0061 0.0049 0.0047 0.7319 0.0028 0.0046 0.0125 0.0062 O. Bengal 6902 0 0.0015 0.0018 0, 0023 0.0013 0.0017 0.0021 0 ,001 0.0016 00140.0011 0.0015 0.006 0.0022 0.0017 0.0013 0.9347 0.0305 0.001 0.0015 0.0016 O. Bengal 6907 2 0.0024 0.0012 0, 0049 0.0052 0.0053 0.0022 0 ,0042 0.0049 05940.0151 0.0043 0.0025 0.007 0.0138 0.0017 0.8549 0.0029 0.001 0.0017 0.0037 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bengal 8399 2 0.0059 0.0156 0 0011 0.0052 0.0144 0.0093 0, 0025 0.0027 00780.0021 0.0023 0.1794 0.0029 0.0057 0.0018 0.6801 0.0023 0.0115 0.0093 0.007 0.
Bengal 8400 13 0.0015 0.002 0 0024 0.0025 0.0028 0.0085 0, 0043 0.0041 003 0.0023 0.0034 0.0035 0.0028 0.0012 0.0022 0.9358 0.0016 0.0049 0.0022 0.002 0.
Bengal 8766 13 0.001 0.002 0 0023 0.0016 0.0011 0.0026 0, 0015 0.0015 00290.0023 0.0022 0.0101 0.0112 0.0118 0.0113 0.9187 0.0011 0.0041 0.0012 0.0056 0.
Bengal 9053 10 0.0071 0.0029 0 0037 0.0022 0.009 0.015 0, 0244 0.0036 00250.005 0.009 0.0225 0.0132 0.0024 0.0028 0.8564 0.0042 0.0053 0.0021 0.0039 0.
Bengal 9800 2 0.0015 0.0021 0 0022 0.0023 0.0019 0.0023 0, 0027 0.0011 003 0.0013 0.0022 0.0012 0.0012 0.0016 0.0014 0.9639 0.0019 0.0021 0.0012 0.0018 O.
Bengal 10344 23 0.0013 0.0013 0 0027 0.0025 0.0022 0.0023 0, 0034 0.0015 0021 0.0022 0.0011 0.0032 0.0027 0.006 0.0016 0.9561 0.0021 0.001 0.0015 0.0021 O.
Bengal 10946 0 0.004 0.0092 0 0351 0.005 0.0045 0.002 0.002 0.0053 054 0.0041 0.0056 0.0163 0.0019 0.0054 0.0039 0.7789 0.0073 0.0027 0.003 0.0087 O.
Bengal 11194 18 0.003 0.007 1181 0.0076 0.0136 0.0113 0, 0063 0.0023 015 0.003 0.0062 0.0025 0.0051 0.0044 0.0078 0.7445 0.0128 0.0022 0.021 0.0047 O.
Sokoke 1890 7 0.001 0.001 001 0.0012 0.001 0.0014 0, 001 0.001 00120.001 0.0013 0.001 0.001 0.099 0.4893 0.2931 0.001 0.0019 0.0018 0.0988 O.
Sokoke 1898 31 0.001 0.001 001 0.0013 0.0033 0.001 0, 0027 0.001 00170.0017 0.001 0.001 0.0012 0.0985 0.4716 0.2823 0.001 0.0086 0.0062 0.1059 O.
Sokoke 2054 7 0.001 0.001 001 0.0012 0.0013 0.001 0, 0013 0.001 001 0.0013 0.0013 0.0013 0.001 0.0992 0.4901 0.2909 0.001 0.0013 0.0027 0.0989 O.
Sokoke 2061 34 0.0031 0.0044 0 ,0046 0.0023 0.0017 0.0018 0, 0023 0.003 00160.0026 0.0026 0.0016 0.0017 0.0974 0.4793 0.2818 0.0012 0.003 0.0024 0.0979 O.
Sokoke 2063 15 0.001 0.002 0 ,0015 0.0014 0.0021 0.0037 0, 0052 0.0027 003 0.0038 0.0027 0.0017 0.0011 0.0974 0.4689 0.2882 0.001 0.0037 0.0077 0.0975 O.
Sokoke 2067 42 0.0049 0.0057 0 ,0027 0.0706 0.0016 0.0271 0, 0021 0.0022 00250.0059 0.0024 0.0046 0.0021 0.0796 0.3918 0.2925 0.0023 0.009 0.0052 0.082 O.
Sokoke 6615 23 0.001 0.0078 0 ,0045 0.0029 0.0016 0.0109 0, 0023 0.0013 01050.0039 0.0051 0.0017 0.0075 0.0905 0.4162 0.2424 0.0014 0.0078 0.0017 0.0923 O.
Ocicat 2933 44 0.0033 0.0026 0 ,0085 0.0063 0.0094 0.0072 0, 0828 0.4183 019 0.0068 0.007 0.002 0.0035 0.0118 0.0021 0.0022 0.003 0.0688 0.0055 0.06 o.
Ocicat 2951 21 0.001 0.007 0 0028 0.0011 0.0022 0.0029 0, 0038 0.0029 678 0.0048 0.0067 0.0023 0.0086 0.0907 0.0027 0.0074 0.0028 0.0393 0.0205 0.0972 O.
Ocicat 2954 26 0.0019 0.0021 0 ,019 0.089 0.0018 0.0028 0, 002 0.0055 62320.0217 0.0041 0.002 0.0044 0.0907 0.0039 0.0233 0.001 0.0054 0.0018 0.0889 O.
Ocicat 3514 47 0.0056 0.0086 0 ,0032 0.0061 0.0023 0.0022 0, 0054 0.0072 6771 0.0061 0.0257 0.0021 0.0094 0.0951 0.0033 0.0036 0.001 0.029 0.0041 0.0979 O.
Ocicat 5744 5 0.0075 0.0048 0 ,0075 0.0106 0.0075 0.0101 0, 0037 0.011 52480.0095 0.0071 0.0072 0.0098 0.0995 0.0032 0.003 0.0153 0.1045 0.0032 0.1311 O.
Ocicat 9966 13 0.0055 0.0017 0 0022 0.0025 0.003 0.0451 0, 0659 0.0076 39380.0044 0.0126 0.0013 0.0245 0.0975 0.0064 0.0052 0.003 0.1382 0.0086 0.1019 O.
Ocicat 9967 2 0.0603 0.0031 0 ,0054 0.0037 0.0026 0.0023 0, 0077 0.0051 49460.0045 0.0026 0.002 0.0064 0.084 0.005 0.003 0.006 0.0861 0.0095 0.1648 O.
Ocicat 10400 2 0.0025 0.0042 0 ,0108 0.0035 0.0017 0.0168 0, 0046 0.0032 55730.0124 0.0071 0.0311 0.006 0.0823 0.0022 0.02 0.0051 0.0894 0.0051 0.0898 O.
Ocicat 10652 2 0.0102 0.0067 0 0076 0.0042 0.0143 0.0019 0, 0017 0.0073 60080.0077 0.0075 0.0027 0.0188 0.1089 0.0011 0.0036 0.0057 0.0537 0.0015 0.1257 O.
Ocicat 10654 0 0.0292 0.0017 0 ,0065 0.0087 0.001 0.0152 0, 0254 0.0129 55380.0017 0.0029 0.0014 0.0035 0.0967 0.0026 0.0018 0.0017 0.0669 0.0083 0.1257 O.
Russian Blue 1834 7 0.001 0.0015 0 ,0017 0.0021 0.001 0.002 001 0.001 001 0.002 0.0021 0.0015 0.0019 0.0016 0.002 0.0026 0.9642 0.0026 0.002 0.0036 O.
Russian Blue 1835 5 0.001 0.001 0 ,001 0.001 0.001 0.001 001 0.001 001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.98 0.001 0.001 0.001 O.
Russian Blue 2505 13 0.001 0.0022 0 ,0011 0.001 0.001 0.001 001 0.001 001 0.0027 0.001 0.0011 0.001 0.001 0.0019 0.0088 0.9667 0.001 0.0022 0.0011 O.
Russian Blue 4068 13 0.001 0.001 0 ,0013 0.0011 0.001 0.003 002 0.002 001 0.0019 0.001 0.001 0.001 0.0014 0.0014 0.0011 0.9697 0.0016 0.0033 0.0019 O.
Russian Blue 4072 23 0.0032 0.0024 0 ,002 0.002 0.002 0.0011 0, 001 0.002 00190.002 0.0028 0.0022 0.002 0.0019 0.0092 0.0014 0.9493 0.0074 0.0011 0.0015 O.
Russian Blue 4074 10 0.0035 0.0048 0 ,0034 0.002 0.0012 0.0108 0, 001 0.2168 002 0.0038 0.0028 0.0032 0.0019 0.001 0.001 0.0011 0.7309 0.0029 0.002 0.0026 O.
Russian Blue 4076 10 0.002 0.0029 0 ,002 0.002 0.001 0.001 0, 001 0.002 00190.002 0.0013 0.0024 0.001 0.001 0.0012 0.0012 0.9687 0.0014 0.001 0.0019 O.
Russian Blue 4077 7 0.001 0.001 0 ,001 0.001 0.001 0.001 0, 001 0.001 001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.9792 0.001 0.001 0.001 O.
Russian Blue 4078 10 0.0029 0.0047 0 0066 0.0067 0.003 0.0069 0, 003 0.0034 0031 0.004 0.0037 0.003 0.0058 0.0046 0.0033 0.0112 0.915 0.002 0.0019 0.0032 O.
Russian Blue 4302 10 0.0011 0.001 0 0017 0.001 0.0027 0.001 0, 0012 0.0018 00120.0013 0.001 0.003 0.0019 0.0012 0.001 0.001 0.9453 0.0022 0.0012 0.0025 O.
Russian Blue 4867 23 0.0018 0.0034 0 0037 0.0022 0.002 0.001 0, 0053 0.0047 02130.0082 0.003 0.001 0.0025 0.0015 0.0015 0.0051 0.9252 0.001 0.0018 0.002 O.
Russian Blue 4869 21 0.002 0.0038 0 002 0.002 0.0024 0.0019 0, 0028 0.0012 001 0.002 0.002 0.002 0.001 0.0019 0.0018 0.0013 0.9566 0.0025 0.0049 0.0035 O.
Russian Blue 5216 7 0.028 0.0027 0 0043 0.002 0.0022 0.0244 0, 1649 0.0581 05770.0026 0.0138 0.0025 0.0037 0.0059 0.002 0.0036 0.5907 0.0047 0.0111 0.009 O.
Russian Blue 5630 34 0.0051 0.0036 0 005 0.0059 0.001 0.004 0.002 0.003 00190.0037 0.0032 0.0037 0.0028 0.0019 0.0029 0.0036 0.9353 0.002 0.0052 0.0026 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 6 8 10 11 12 13 14 15 16 17 18 19 20 2
Russian Blue 5631 15 0.0044 0.0172 0, 0088 0.0043 0.002 0.002 0 ,0025 0.001 00350.0039 0.0023 0.0048 0.0012 0.0022 0.002 0.0021 0.9265 0.002 0.002 0.0026 0.
Russian Blue 5704 7 0.0014 0.001 0, 0017 0.001 0.001 0.001 0 ,002 0.0018 001 0.0018 0.0014 0.001 0.001 0.001 0.001 0.001 0.9758 0.001 0.001 0.0011 0.
Russian Blue 5709 15 0.0022 0.0029 0, 0017 0.0036 0.002 0.003 0 ,001 0.002 001 0.0013 0.001 0.002 0.001 0.0011 0.0012 0.001 0.9667 0.0019 0.001 0.0014 0.
Aust. Mist 4716 86 0.0221 0.0471 0. 1068 0.0059 0.034 0.0167 0 .0471 0.0124 0071 0.0291 0.024 0.0186 0.0092 0.0107 0.1018 0.023 0.1247 0.3026 0.0111 0.0283 0.
Aust. Mist 4718 2 0.0317 0.0024 0. 0108 0.0037 0.0023 0.0081 0 .001 0.0317 008 0.0528 0.0629 0.0488 0.0129 0.0059 0.0019 0.0048 0.001 0.6997 0.0018 0.0059 O.
Aust. Mist 4720 15 0.0024 0.002 0, 0044 0.0047 0.0048 0.002 0 ,0072 0.0042 014 0.0083 0.0069 0.002 0.0091 0.0055 0.0016 0.0027 0.0019 0.8976 0.0024 0.0133 O.
Aust. Mist 4722 13 0.0117 0.0035 0, 0079 0.0103 0.0051 0.0037 0 ,0264 0.0275 00570.0127 0.0258 0.0036 0.0069 0.0051 0.0011 0.0024 0.0021 0.8215 0.0013 0.0138 O.
Aust. Mist 4723 10 0.0038 0.0023 0, 0051 0.0081 0.0065 0.0093 0 ,0296 0.0107 004 0.0124 0.0374 0.0025 0.023 0.0059 0.0075 0.0037 0.0016 0.7855 0.0068 0.0075 O.
Aust. Mist 4724 84 0.013 0.0498 0, 0201 0.0089 0.0067 0.0114 0 ,011 0.0134 02170.0258 0.0154 0.0092 0.6192 0.0728 0.0299 0.0174 0.003 0.0061 0.0054 0.0357 O.
Aust. Mist 4725 21 0.004 0.0142 0, 0084 0.0155 0.0224 0.0023 0 ,0029 0.0171 01470.0142 0.0278 0.0103 0.0061 0.0058 0.0041 0.0475 0.0111 0.749 0.0077 0.0075 O.
Aust. Mist 4727 0 0.002 0.0024 0. 0061 0.007 0.0033 0.0588 0 ,002 0.0028 00640.0219 0.1028 0.0066 0.0022 0.003 0.0016 0.0037 0.0024 0.7511 0.0047 0.0034 O.
Aust. Mist 4731 26 0.0034 0.001 0, 002 0.2342 0.002 0.0079 0 ,0137 0.003 01080.0026 0.0028 0.002 0.0041 0.0018 0.0015 0.0015 0.0012 0.6965 0.002 0.0037 O.
Aust. Mist 4736 44 0.0019 0.0014 0, 0026 0.0022 0.0017 0.0021 0 ,0021 0.0033 006 0.0053 0.0063 0.001 0.0074 0.0128 0.0047 0.0021 0.001 0.9273 0.002 0.0048 O.
Aust. Mist 4739 28 0.0026 0.0076 0, 0048 0.0174 0.0022 0.0115 0 ,0029 0.0094 00840.0034 0.0362 0.015 0.0036 0.0022 0.0018 0.0026 0.002 0.8503 0.0067 0.0066 O.
Aust. Mist 6184 2 0.0067 0.0079 0, 0101 0.0051 0.002 0.0376 0 ,0044 0.0024 00330.0035 0.0225 0.0023 0.0022 0.0024 0.0027 0.0022 0.002 0.8309 0.0039 0.0072 O.
Aust. Mist 6187 2 0.0184 0.0078 0, 0261 0.0051 0.0036 0.0121 0 ,0088 0.0101 01170.0103 0.0233 0.0034 0.0053 0.0066 0.0029 0.0042 0.0084 0.7978 0.0113 0.0163 O. j Aust. Mist 6188 7 0.0053 0.0143 0. 032 0.0228 0.0071 0.0145 0 ,0049 0.0338 0811 0.0126 0.0737 0.002 0.0106 0.0063 0.002 0.0173 0.0036 0.5904 0.0042 0.0133 O.
Aust. Mist 6189 7 0.0164 0.0073 0. 0061 0.0167 0.0065 0.0042 0 ,002 0.0052 00220.0085 0.0064 0.002 0.0014 0.002 0.0011 0.0017 0.0049 0.8746 0.0174 0.0106 O.
Burmese 21 5 0.0049 0.0027 0, 002 0.0026 0.0049 0.001 0 ,0022 0.001 00430.0068 0.0025 0.001 0.001 0.0012 0.0012 0.0011 0.003 0.9204 0.0034 0.0172 O.
Burmese 22 5 0.0013 0.0013 0, 0013 0.0036 0.001 0.0027 0 ,0016 0.0014 00130.0017 0.0018 0.0025 0.0015 0.0014 0.0027 0.0079 0.0026 0.9442 0.009 0.0033 O.
Burmese 23 5 0.0018 0.0023 0, 0017 0.001 0.0011 0.0021 0 ,0029 0.0018 00160.0021 0.0024 0.0025 0.0021 0.0012 0.0024 0.0017 0.0012 0.888 0.002 0.0026 O.
Burmese 24 7 0.0019 0.002 0, 0019 0.002 0.0021 0.0021 0 ,0189 0.0224 002 0.0039 0.0051 0.0333 0.0605 0.0033 0.0018 0.0011 0.0027 0.8254 0.0024 0.0026 O.
Burmese 25 5 0.001 0.0011 0, 001 0.002 0.0021 0.001 0 ,0026 0.0015 00340.0011 0.0017 0.002 0.002 0.0017 0.0023 0.0019 0.001 0.9163 0.0404 0.004 O.
Burmese 26 7 0.0025 0.009 0. 0026 0.01 0.0029 0.0033 0 ,002 0.001 00220.0085 0.0034 0.001 0.0037 0.0025 0.0011 0.0017 0.0016 0.9098 0.0091 0.0067 O.
Burmese 27 7 0.0024 0.0018 0, 0021 0.002 0.001 0.0055 0 ,0312 0.0019 00430.0054 0.0033 0.0099 0.0015 0.0027 0.0017 0.005 0.0047 0.8194 0.0064 0.0725 O.
Burmese 28 10 0.0127 0.0012 0, 0025 0.001 0.002 0.001 0 ,002 0.0026 00490.0013 0.0018 0.0016 0.001 0.0012 0.0012 0.0011 0.0019 0.9462 0.001 0.0063 O.
Burmese 29 7 0.001 0.0013 0, 0013 0.0013 0.001 0.001 0 ,0011 0.001 0021 0.002 0.0023 0.0132 0.0014 0.0041 0.0077 0.0013 0.001 0.9405 0.0062 0.0024 O.
Burmese 4401 13 0.0018 0.0011 0, 001 0.0014 0.0031 0.0014 0 ,0023 0.0044 00270.0022 0.0022 0.0015 0.0013 0.0029 0.0071 0.0076 0.002 0.8144 0.13 0.0033 O.
Burmese 4691 18 0.0054 0.007 0, 0085 0.0042 0.0211 0.0636 0 ,0022 0.0086 00170.019 0.0074 0.0021 0.0034 0.0173 0.0365 0.009 0.0075 0.7569 0.0019 0.0098 O.
Burmese 4781 18 0.001 0.0026 0. 001 0.0013 0.001 0.0025 0 ,0013 0.0013 00130.001 0.0012 0.001 0.001 0.0017 0.0025 0.0017 0.0013 0.9301 0.0079 0.0021 O.
Burmese 4782 18 0.0031 0.0011 0, 0021 0.002 0.001 0.002 0 ,003 0.001 0041 0.0012 0.0031 0.0013 0.002 0.0018 0.0015 0.0022 0.001 0.8325 0.0021 0.0032 0.
Burmese 5425 7 0.0015 0.002 0, 0027 0.004 0.001 0.002 0 ,0013 0.0021 00450.0042 0.0053 0.0047 0.0086 0.0023 0.0139 0.0025 0.0017 0.8858 0.0029 0.0035 O.
Burmese 5800 15 0.0035 0.0045 0, 0018 0.0022 0.001 0.0026 0 ,0065 0.0042 00180.002 0.0028 0.002 0.0013 0.0027 0.0028 0.0027 0.002 0.8922 0.0055 0.007 O.
Burmese 6182 13 0.0038 0.0015 0, 0037 0.0013 0.001 0.001 0 ,0028 0.0044 00130.0088 0.0038 0.0027 0.0013 0.0012 0.0032 0.001 0.0303 0.9028 0.0028 0.0046 O.
Burmese 6471 18 0.0011 0.001 0, 001 0.001 0.001 0.001 0.001 0.001 00660.001 0.001 0.0029 0.001 0.0018 0.0022 0.0022 0.001 0.8969 0.0229 0.0066 O.
Burmese 6962 15 0.0013 0.0013 0, 0022 0.001 0.0011 0.0013 0 ,0026 0.001 001 0.0014 0.0013 0.001 0.001 0.0019 0.0022 0.001 0.0024 0.7499 0.2 0.0028 O.
Burmese 6964 23 0.0017 0.0028 0. 0018 0.0018 0.001 0.0048 0 ,0023 0.0014 00980.0024 0.0034 0.0013 0.0027 0.0026 0.002 0.0026 0.0013 0.9276 0.0186 0.0026 O.
Birman 1760 7 0.0036 0.0092 0, 0078 0.01 0.001 0.001 0 ,0036 0.0051 0011 0.0039 0.0054 0.001 0.0104 0.0031 0.001 0.001 0.0122 0.001 0.914 0.0025 O.
Birman 2917 28 0.001 0.0011 0, 0011 0.001 0.002 0.0018 0 ,0037 0.002 00120.001 0.0017 0.001 0.001 0.0015 0.001 0.001 0.0018 0.001 0.9712 0.0016 O.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 2
Birman 3910 10 0.0034 0.0142 0, 002 0.0018 0.0102 0.0017 0 ,0026 0.0011 0011 0.002 0.0032 0.0015 0.0035 0.0018 0.0026 0.0019 0.003 0.0013 0.9382 0.0018 0.
Birman 5029 7 0.0024 0.0098 0, 0042 0.0064 0.001 0.0051 0 ,0034 0.0019 01580.0042 0.0088 0.0065 0.0024 0.0018 0.0013 0.0018 0.0029 0.0017 0.9133 0.0036 0.
Birman 5033 7 0.001 0.001 0, 0011 0.0011 0.001 0.0033 0 ,0017 0.001 00170.001 0.001 0.001 0.001 0.0012 0.0012 0.0016 0.001 0.0023 0.9717 0.0011 0.
Birman 5034 5 0.0145 0.0221 0. 003 0.0038 0.0178 0.002 0 ,0032 0.003 00290.0061 0.0065 0.002 0.0039 0.0033 0.0018 0.0011 0.0115 0.005 0.8733 0.0089 0.
Birman 5038 10 0.0168 0.0049 0. 0044 0.0032 0.0034 0.0024 0 ,0025 0.0035 00160.0026 0.0033 0.0049 0.0026 0.0023 0.0021 0.0017 0.0237 0.0032 0.9049 0.0038 O.
Birman 5151 7 0.0034 0.0038 0, 0031 0.0015 0.0017 0.0027 0 ,003 0.0021 00240.0019 0.0061 0.001 0.0048 0.0017 0.0086 0.0015 0.0018 0.0027 0.9408 0.0024 O.
Birman 5576 23 0.0038 0.0011 0, 0018 0.0013 0.0036 0.001 0 ,002 0.0019 00380.001 0.001 0.001 0.001 0.001 0.0011 0.0011 0.0017 0.0016 0.9656 0.0016 O.
Birman 5578 15 0.0169 0.0116 0, 0041 0.056 0.0221 0.0129 0 ,012 0.0078 00930.002 0.005 0.0044 0.0038 0.0082 0.0021 0.0039 0.0072 0.021 0.6749 0.0617 O.
Birman 6448 10 0.0046 0.0016 0, 0018 0.0029 0.0016 0.0017 0 ,0024 0.0017 001 0.0027 0.0017 0.016 0.0017 0.0011 0.001 0.002 0.0031 0.002 0.9452 0.0019 O.
Birman 6450 15 0.0019 0.001 001 0.002 0.0016 0.001 0 ,0027 0.0036 00180.001 0.001 0.001 0.001 0.0016 0.001 0.001 0.0011 0.0026 0.9655 0.0025 O.
Birman 6526 21 0.001 0.001 001 0.001 0.001 0.001 0 ,0011 0.001 001 0.001 0.001 0.001 0.001 0.0011 0.0011 0.001 0.001 0.001 0.9793 0.001 O.
Birman 6527 13 0.001 0.001 0017 0.001 0.0038 0.0017 0 ,001 0.0025 00190.0017 0.0017 0.0028 0.0016 0.0013 0.001 0.001 0.0017 0.0013 0.9661 0.0022 O.
Birman 6528 15 0.0013 0.001 0017 0.001 0.0018 0.0011 0 ,001 0.0014 00180.0017 0.0018 0.001 0.001 0.0012 0.0017 0.0011 0.001 0.002 0.9711 0.0016 O.
Birman 6529 15 0.0122 0.0034 0, 0018 0.0019 0.0036 0.0023 0 ,0152 0.0017 00170.0017 0.0018 0.0017 0.0027 0.002 0.0075 0.0021 0.0016 0.001 0.9315 0.0016 O.
Birman 6604 5 0.0019 0.0025 0, 0035 0.003 0.0029 0.0046 0 ,0153 0.0042 00280.0043 0.003 0.001 0.002 0.002 0.0013 0.0022 0.001 0.0016 0.9354 0.0033 O.
Birman 6607 10 0.0022 0.0017 0, 0017 0.001 0.0011 0.0017 0 ,0017 0.001 00170.0011 0.0014 0.001 0.0021 0.001 0.0064 0.0013 0.002 0.001 0.9668 0.0011 O.
Birman 6608 5 0.0014 0.0017 0. 0029 0.002 0.0025 0.0091 0 ,0222 0.0027 00160.0019 0.0045 0.0022 0.0027 0.0019 0.0011 0.002 0.001 0.0016 0.9313 0.0017 O.
Birman 6609 10 0.0451 0.0027 0. 0033 0.0017 0.0034 0.0014 0 ,0176 0.0017 00180.0039 0.0062 0.002 0.0011 0.0072 0.001 0.0011 0.0043 0.0044 0.8781 0.0085 O.
Havana Brn. 787 7 0.0035 0.0021 0, 0028 0.0035 0.0022 0.001 ,0039 0.0019 00150.0014 0.0035 0.001 0.0013 0.0014 0.0012 0.0019 0.004 0.3056 0.0015 0.384 o.
Havana Brn. 2415 47 0.0036 0.0019 0, 0017 0.0026 0.0146 0.002 ,0023 0.0026 00580.0016 0.0025 0.0013 0.0026 0.0019 0.0013 0.0029 0.0054 0.2886 0.003 0.3842 0.
Havana Brn. 2500 10 0.0057 0.0042 0, 0021 0.003 0.0017 0.001 ,002 0.0028 00350.002 0.0028 0.0032 0.002 0.002 0.0017 0.0012 0.0033 0.2846 0.002 0.3804 o.
Havana Brn. 2501 36 0.0014 0.0012 0, 0014 0.0013 0.002 0.001 ,0036 0.0022 0021 0.0011 0.0018 0.002 0.0017 0.0014 0.001 0.001 0.0016 0.292 0.003 0.3808 o.
Havana Brn. 2502 28 0.002 0.0024 0, 0016 0.0016 0.001 0.0014 0 ,0023 0.0013 0021 0.0013 0.0018 0.0013 0.0013 0.0012 0.001 0.001 0.0013 0.2923 0.0018 0.3911 o.
Havana Brn. 3312 34 0.0016 0.0019 0. 0014 0.0016 0.0016 0.001 0 ,0026 0.002 00260.002 0.0019 0.0016 0.0013 0.0012 0.0013 0.0011 0.0022 0.2879 0.0052 0.3881 o.
Havana Brn. 3404 10 0.001 0.003 0, 0033 0.0017 0.0043 0.0017 0 ,0017 0.0101 00320.0031 0.0022 0.0017 0.002 0.0029 0.0017 0.0021 0.0033 0.2916 0.0017 0.3814 o.
Havana Brn. 3513 13 0.0019 0.0037 0, 003 0.0017 0.0032 0.0027 0 ,0919 0.0035 0011 0.0056 0.0154 0.0011 0.0023 0.0015 0.0015 0.0016 0.0023 0.2551 0.0032 0.3547 0.
Havana Brn. 5707 7 0.0019 0.0025 0, 002 0.0019 0.0032 0.0019 0 ,0017 0.0117 00160.0014 0.0017 0.0031 0.0014 0.0018 0.001 0.0013 0.0048 0.2854 0.001 0.3918 o.
Havana Brn. 5708 13 0.0029 0.0035 0, 0031 0.0199 0.0014 0.0017 0 ,0018 0.0177 0041 0.0141 0.0031 0.0134 0.0047 0.0017 0.007 0.003 0.0022 0.2806 0.0012 0.3648 0.
Havana Brn. 6972 13 0.0034 0.0161 0, 0026 0.0097 0.0107 0.0021 0 ,0023 0.0082 00130.0033 0.0023 0.0017 0.0046 0.002 0.0011 0.001 0.0101 0.2627 0.0014 0.3858 0.
Havana Brn. 6973 21 0.0015 0.0046 0. 004 0.0079 0.0086 0.002 0 ,0026 0.002 00170.003 0.0021 0.0017 0.0035 0.0022 0.0013 0.002 0.0057 0.267 0.0021 0.387 o.
Havana Brn. 10350 13 0.0031 0.0014 0, 0019 0.0016 0.0016 0.0034 0 ,0017 0.0062 00320.0019 0.0029 0.0069 0.0019 0.002 0.001 0.0015 0.0016 0.2849 0.0023 0.3909 o.
Havana Brn. 5554 28 0.0014 0.0021 0, 0024 0.0019 0.0059 0.001 0 ,0026 0.0023 00140.0017 0.0019 0.0033 0.0024 0.0012 0.001 0.0021 0.0078 0.2725 0.0013 0.3811 o.
Korat 4708 5 0.0017 0.0034 0, 0021 0.0031 0.002 0.0048 0 ,006 0.0013 00640.0022 0.0025 0.0033 0.0029 0.0038 0.002 0.0021 0.0018 0.0018 0.6506 0.0031 o.
Korat 4711 5 0.001 0.0018 0, 001 0.002 0.001 0.002 0 ,0018 0.001 0011 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.001 0.0017 0.6819 0.0014 o.
Korat 5059 7 0.001 0.0018 0, 001 0.0016 0.0019 0.001 0 ,001 0.001 001 0.001 0.001 0.001 0.001 0.0011 0.0014 0.0014 0.001 0.0112 0.6496 0.0283 o.
Korat 5069 5 0.0043 0.0195 0, 0047 0.0173 0.002 0.006 0 ,0011 0.0022 00380.0034 0.0032 0.0067 0.0023 0.0111 0.005 0.0049 0.0012 0.0154 0.6021 0.0085 o.
Korat 5098 7 0.001 0.0022 0. 0012 0.0024 0.0049 0.0026 0 ,002 0.001 0011 0.0013 0.0013 0.0011 0.0013 0.0015 0.0014 0.002 0.0013 0.003 0.6807 0.0018 o.
Korat 5175 5 0.001 0.0013 0, 001 0.001 0.001 0.002 0 ,0029 0.001 00170.0011 0.0016 0.0011 0.0019 0.0012 0.0011 0.0012 0.0013 0.0103 0.649 0.0241 o.
Korat 5176 5 0.001 0.0014 0, 0022 0.0027 0.002 0.001 0 ,0014 0.0019 00290.0031 0.0017 0.001 0.0011 0.0016 0.0019 0.002 0.001 0.0296 0.5911 0.058 o.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 6 10 11 12 13 14 15 16 17 18 19 20 2
Korat 5177 5 0.001 0.001 0, 001 0.002 0.001 0.0014 0 ,0012 0.001 00150.001 0.0014 0.001 0.001 0.0012 0.0146 0.0016 0.0014 0.171 0.5363 0.006 o.
Korat 5178 7 0.001 0.0023 0, 0011 0.002 0.0013 0.0013 0 ,002 0.001 002 0.0013 0.0015 0.0022 0.0017 0.0021 0.0022 0.0012 0.002 0.002 0.679 0.0016 o.
Korat 5224 5 0.0016 0.0017 0, 002 0.0011 0.0017 0.0034 0 ,002 0.0017 0011 0.0018 0.0026 0.0033 0.002 0.0014 0.0018 0.0029 0.0035 0.0034 0.6672 0.0055 o.
Korat 5237 7 0.0126 0.0096 0. 007 0.0088 0.0038 0.002 0 ,002 0.0026 00430.0018 0.0029 0.0234 0.0029 0.0066 0.0118 0.0138 0.001 0.0083 0.6129 0.0075 o.
Korat 5240 5 0.001 0.001 0. 0014 0.002 0.0011 0.0017 0 ,001 0.001 00140.001 0.001 0.001 0.0012 0.0015 0.002 0.0014 0.0012 0.0052 0.6789 0.0026 o.
Korat 5242 5 0.001 0.001 0, 001 0.001 0.001 0.001 0 ,001 0.001 0011 0.001 0.001 0.001 0.001 0.0011 0.0011 0.001 0.0018 0.0024 0.6841 0.0026 o.
Korat 5244 5 0.001 0.0011 0, 001 0.002 0.0015 0.0015 0 ,001 0.001 002 0.001 0.001 0.001 0.001 0.0011 0.0011 0.0013 0.0013 0.0022 0.6983 0.002 o.
Korat 5284 7 0.001 0.001 0, 001 0.001 0.0021 0.002 0 ,002 0.001 00330.001 0.0014 0.0013 0.001 0.0017 0.0017 0.0013 0.001 0.1027 0.5843 0.0074 o.
Korat 5344 5 0.001 0.001 0, 0011 0.001 0.001 0.0013 0 ,0065 0.002 005 0.0017 0.0014 0.001 0.0014 0.0021 0.002 0.0024 0.0034 0.0041 0.6631 0.0053 o.
Korat 5481 5 0.001 0.0017 0, 0016 0.0045 0.001 0.0064 0 ,0014 0.0017 00280.0014 0.0019 0.0013 0.0017 0.0019 0.0024 0.0033 0.0019 0.0115 0.6558 0.0034 o.
Korat 5512 5 0.001 0.0013 0. 0011 0.0037 0.0013 0.0028 0 ,001 0.001 002 0.0019 0.0013 0.0017 0.002 0.0011 0.0012 0.0021 0.0013 0.0057 0.6975 0.0028 o.
Korat 5514 5 0.0017 0.0021 0, 0022 0.0017 0.001 0.002 0 ,001 0.0017 0011 0.001 0.0015 0.001 0.001 0.0011 0.0011 0.001 0.001 0.0025 0.6633 0.0023 o.
Korat 5595 5 0.001 0.001 0, 0016 0.0023 0.002 0.0026 0 ,001 0.001 0011 0.002 0.0017 0.0026 0.0015 0.0035 0.0052 0.0029 0.002 0.0954 0.576 0.0105 o.
Korat 5597 7 0.001 0.002 0, 0032 0.0032 0.0016 0.0033 0 ,0017 0.002 00730.002 0.0037 0.0034 0.0027 0.0043 0.003 0.0054 0.001 0.0474 0.6235 0.0046 o.
Korat 6375 5 0.001 0.0012 0, 0013 0.001 0.0034 0.0021 0 ,003 0.002 00420.002 0.0022 0.001 0.0158 0.0975 0.0045 0.0051 0.0017 0.0791 0.4248 0.088 o.
Korat 6376 7 0.001 0.0017 0, 0022 0.0019 0.0017 0.0051 0 ,001 0.001 00280.0022 0.0116 0.0017 0.0018 0.0028 0.001 0.0022 0.0017 0.0668 0.4568 0.0718 o.
Korat 6377 5 0.001 0.0011 0. 0014 0.0018 0.0012 0.0514 0 ,0023 0.0023 00450.0025 0.0021 0.003 0.0012 0.0073 0.0016 0.0018 0.0021 0.1067 0.429 0.0903 o.
Korat 6378 5 0.0023 0.0021 0. 0019 0.002 0.0021 0.0191 0 ,0044 0.0022 00870.0036 0.0023 0.0014 0.0032 0.0067 0.0104 0.0018 0.0026 0.1016 0.4425 0.1102 o.
Siamese 2868 7 0.001 0.0021 0, 0014 0.0021 0.0032 0.0053 0 ,001 0.002 006 0.0014 0.0017 0.001 0.001 0.0026 0.005 0.0027 0.0011 0.3468 0.0293 0.3171 o.
Siamese 6686 28 0.0068 0.0021 0, 0022 0.0028 0.0014 0.0012 0 ,0037 0.0025 002 0.1366 0.0042 0.0063 0.0135 0.0029 0.0059 0.0024 0.0023 0.2729 0.002 0.3335 0.
Siamese 6688 10 0.0019 0.0022 0, 0018 0.0059 0.005 0.0036 0 ,0113 0.002 00740.0037 0.0033 0.0027 0.0038 0.0026 0.0027 0.0027 0.0035 0.3084 0.006 0.3178 o.
Siamese 6690 18 0.0014 0.0049 0, 0029 0.0092 0.0019 0.0023 0 ,0013 0.0013 00250.0031 0.0021 0.0015 0.0015 0.0034 0.0025 0.0053 0.0038 0.2853 0.002 0.3935 0.
Siamese 6696 15 0.001 0.0012 0, 0023 0.0024 0.0013 0.0028 0 ,0055 0.0018 00320.0018 0.0013 0.001 0.0021 0.002 0.0035 0.0018 0.0068 0.2498 0.1412 0.3094 o.
Siamese 7839 10 0.001 0.001 0. 0011 0.001 0.0016 0.0014 0 ,003 0.001 0021 0.001 0.001 0.001 0.0011 0.003 0.0012 0.001 0.001 0.2979 0.0073 0.3802 o.
Siamese 8181 10 0.001 0.0017 0, 0019 0.0016 0.0017 0.0014 0 ,0026 0.0016 00140.0016 0.0025 0.0014 0.001 0.0011 0.001 0.0013 0.0016 0.2929 0.0022 0.3904 o.
Siamese 8182 7 0.001 0.001 0, 001 0.0013 0.001 0.0013 0 ,0013 0.0016 00130.0012 0.001 0.0017 0.001 0.0011 0.001 0.0033 0.001 0.3154 0.0023 0.3818 o.
Siamese 8184 13 0.0016 0.0023 0, 0018 0.003 0.0017 0.0169 0 ,0509 0.003 00350.0109 0.003 0.003 0.002 0.0028 0.0026 0.0093 0.0023 0.3273 0.0057 0.3575 0.
Siamese 8185 10 0.0037 0.0033 0, 0025 0.0028 0.0019 0.0076 0 ,0197 0.0033 00450.0138 0.0031 0.002 0.0022 0.004 0.019 0.0051 0.0212 0.259 0.008 0.3659 0.
Siamese 8187 5 0.0016 0.0014 0, 0013 0.0027 0.0022 0.002 0 ,0051 0.0013 00160.0015 0.0013 0.001 0.0013 0.0016 0.0014 0.0019 0.0014 0.2767 0.128 0.3118 o.
Siamese 8251 13 0.0024 0.0075 0. 0029 0.0014 0.001 0.0266 0 ,01 1 0.001 00250.0019 0.0024 0.0025 0.0022 0.0055 0.001 0.0011 0.0026 0.2803 0.0854 0.2768 0.
Siamese 8253 5 0.001 0.002 0, 0037 0.0023 0.0029 0.0026 0 ,0121 0.001 00380.0015 0.0012 0.0013 0.0016 0.0025 0.001 0.0029 0.0042 0.3692 0.0088 0.2998 0.
Siamese 8258 10 0.0011 0.0034 0, 0011 0.002 0.0011 0.0015 0 ,0015 0.0013 00150.002 0.001 0.0013 0.001 0.0016 0.0019 0.0013 0.0027 0.2845 0.0262 0.3747 0.
Siamese 8259 5 0.0013 0.0014 0, 0027 0.0042 0.0043 0.0159 0 ,0036 0.002 00220.0026 0.0034 0.0017 0.002 0.0024 0.0027 0.0027 0.0025 0.2744 0.0365 0.3478 0.
Singapura 3428 39 0.001 0.0024 0, 0019 0.007 0.0035 0.002 0 ,0042 0.0026 00390.0027 0.0028 0.0053 0.002 0.003 0.0026 0.0019 0.0046 0.0455 0.0172 0.0123 O.
Singapura 3919 26 0.001 0.0012 0, 0012 0.001 0.001 0.0013 0 ,0013 0.0013 00250.001 0.0012 0.001 0.0013 0.0014 0.0013 0.001 0.001 0.0016 0.001 0.0021 0.
Singapura 4464 7 0.001 0.0012 0, 0013 0.001 0.001 0.0027 0 ,0021 0.0012 00170.001 0.0011 0.0011 0.0013 0.0016 0.001 0.001 0.0017 0.0028 0.0011 0.0011 0.
Singapura 4467 7 0.001 0.001 0. 0011 0.001 0.001 0.0012 0 ,0013 0.001 00180.001 0.001 0.001 0.001 0.001 0.001 0.001 0.0021 0.0025 0.0013 0.0014 0.
Singapura 4468 31 0.001 0.0013 0, 0013 0.0013 0.001 0.0013 0 ,0013 0.0013 00180.0013 0.0013 0.0016 0.0016 0.0013 0.001 0.0011 0.0013 0.0063 0.001 0.0012 0.
Singapura 4469 7 0.001 0.0012 0, 0016 0.001 0.001 0.0013 0 ,0013 0.0013 00390.0013 0.0013 0.0013 0.0013 0.0016 0.001 0.001 0.001 0.0027 0.0013 0.0014 0.
Table 18 - Population clustering of each pedigreed individual in the database by STRs at K = 21
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 t 1 12 13 14 15 16 17 18 19 20
Singapura 4470 5 0, .001 0, .0012 0, .0016 0, .001 0, .001 0, .0013 0, .0013 0, .001 0, .0013 0.0013 0, .0012 0.0013 0, .0013 0, .0016 0, .001 0.0039 0.0011 0, .0026 0, .001 0, .001
Singapura 4471 5 0, .001 0, .0012 0, .0016 0, .001 0, .001 0, .001 0, .0013 0, .001 0, .0086 0.0013 0, .0014 0.0013 0, .0013 0, .0012 0, .001 0.001 0.0044 0, .0016 0, .0037 0, .001
Singapura 4472 5 0, .001 0, .0012 0, .0029 0, .0021 0, .0013 0, .0011 0, .0013 0, .001 0, .0768 0.0013 0, .0029 0.0028 0, .0016 0, .0013 0, .0013 0.0011 0.001 0, .0022 0, .0013 0, .001
Singapura 4473 18 0, .002 0, .0012 0, .0015 0, .0013 0, .005 0, .0013 0, .0046 0, .002 0, .0019 0.0023 0, .0016 0.004 0, .0039 0, .001 0, .001 0.001 0.001 0, .0027 0, .0022 0, .002
Singapura 4474 28 0, .0037 0, .002 0, .0044 0, .0044 0, .0027 0, .0023 0, .0051 0, .0039 0, .0373 0.0026 0, .0049 0.0037 0, .002 0, .0043 0, .0026 0.0016 0.0026 0, .0383 0, .0019 0, .005
Singapura 4485 31 0, .0016 0, .0019 0, .002 0, .002 0, .001 0, .002 0, .0023 0, .001 0, .0056 0.002 0, .002 0.0022 0, .0023 0, .0044 0, .0016 0.0017 0.0017 0, .0028 0, .0045 0, .003
Singapura 4486 18 0, .0012 0, .0019 0, .0027 0, .001 0, .001 0, .0023 0, .0019 0, .0019 0, .0067 0.0016 0, .0014 0.0016 0, .0015 0, .0043 0, .0013 0.0013 0.0013 0, .0044 0, .0013 0, .001
Singapura 4487 18 0, .001 0, .0058 0, .0045 0, .0016 0, .0015 0, .001 0, .0031 0, .0012 0, .0055 0.0028 0, .0028 0.002 0, .0014 0, .0016 0, .002 0.001 0.0029 0, .0068 0, .0381 0, .003
Singapura 4488 21 0, .0012 0, .0027 0, .0041 0, .002 0, .001 0, .0064 0, .0027 0, .0016 0, .0196 0.0036 0, .0024 0.0011 0, .0013 0, .0017 0, .0013 0.0014 0.0015 0, .0038 0, .0022 0, .003
Singapura 6597 5 0, .001 0, .001 0, .001 0, .001 0, .001 0, .001 0, .001 0, .001 0, .0018 0.001 0, .001 0.001 0, .001 0, .001 0, .001 0.001 0.001 0, .0061 0, .0013 0, .001
Singapura 6975 21 0, .0016 0, .0015 0, .002 0, .0019 0, .001 0, .0023 0, .003 0, .0017 0, .0152 0.0019 0, .002 0.001 0, .002 0, .0018 0, .0014 0.0011 0.0017 0, .0072 0, .001 0, .002
o
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Persian 1250 9 0.0065 0.0352 0.0036 0, .001 0, ,0034 0, .0042 0.0203 0, .0035 0.0022 0.0068 0.885 0.0044 0.0073 0, .0052 0.0029 0, .0046 0.0039
Persian 1939 4 0.0011 0.0013 0.001 0, .001 0, ,0019 0, .0027 0.001 0, .001 0.001 0.001 0.9786 0.001 0.002 0, .0011 0.002 0, .001 0.0013
Persian 2071 8 0.0024 0.0046 0.0022 0. .0029 0. ,0605 0, .002 0.002 0, .0023 0.0025 0.003 0.8831 0.0022 0.0027 0, .002 0.011 0, .0057 0.0089
Persian 2088 0 0.0125 0.0039 0.0021 0, .0192 0, ,0684 0, .0023 0.0026 0, .0022 0.0011 0.0079 0.8201 0.0024 0.003 0, .003 0.0198 0, .002 0.0275
Persian 2140 7 0.001 0.0019 0.0014 0, .0041 0, ,002 0, .0044 0.0023 0, .0016 0.001 0.002 0.966 0.0024 0.0018 0, .0019 0.0025 0, .002 0.0017
Persian 2174 2 0.0018 0.0012 0.0015 0, .0035 0, ,0071 0, .002 0.002 0, .0018 0.002 0.0018 0.9602 0.0011 0.0011 0, .0016 0.0055 0, .003 0.0028
Persian 2209 4 0.0031 0.0063 0.003 0, .002 0, ,0068 0, .0051 0.0107 0, .0099 0.0018 0.003 0.8757 0.0045 0.0073 0, .0173 0.0339 0, .0048 0.0048
Persian 2215 21 0.0024 0.0048 0.0052 0, .0118 0, ,0062 0, .0033 0.0039 0, .0033 0.0018 0.0078 0.9129 0.0035 0.0033 0, .0083 0.0125 0, .0054 0.0036
Persian 2890 8 0.0029 0.003 0.0255 0, .0033 0, ,0126 0, .0033 0.0102 0, .0077 0.002 0.0061 0.8256 0.0146 0.0057 0, .0188 0.0133 0, .003 0.0423
Persian 2977 3 0.0406 0.0043 0.0029 0, .0037 0, ,0896 0, .006 0.0202 0, .0123 0.0022 0.0099 0.7185 0.0189 0.0121 0, .0089 0.0172 0, .0105 0.0223
Persian 4143 8 0.0031 0.0033 0.0032 0. .0163 0. ,004 0, .0074 0.003 0, .0081 0.0032 0.0065 0.9183 0.0026 0.0066 0, .0038 0.0039 0, .0028 0.004
Persian 4168 4 0.0048 0.0061 0.0031 0, .0112 0, ,0092 0, .001 0.0067 0, .0041 0.0028 0.0055 0.9075 0.0039 0.0037 0, .0093 0.0074 0, .0083 0.0054
Persian 4169 2 0.002 0.0056 0.001 0, .001 0, ,002 0, .0026 0.002 0, .002 0.001 0.0028 0.9684 0.0011 0.002 0, .0017 0.001 0, .002 0.0018
Persian 4950 0 0.0019 0.002 0.0013 0, .0045 0, ,001 0, .0032 0.0025 0, .0031 0.001 0.003 0.9638 0.0011 0.003 0, .0026 0.0018 0, .0022 0.002
Persian 4953 1 0.001 0.001 0.001 0, .001 0, ,002 0, .001 0.001 0, .001 0.0009 0.001 0.9831 0.001 0.001 0, .001 0.0011 0, .001 0.001
Exotic SH 258 0 0.001 0.001 0.001 0. .0029 0. ,0044 0, .003 0.001 0, .0011 0.001 0.001 0.9748 0.001 0.001 0, .001 0.002 0, .0012 0.0016
Exotic SH 259 3 0.0038 0.0114 0.002 0, .005 0, ,0171 0, .0027 0.0022 0, .0044 0.0032 0.0029 0.9282 0.0021 0.003 0, .0022 0.0024 0, .002 0.0054
Exotic SH 260 4 0.0061 0.0047 0.0048 0, .0044 0, ,0107 0, .002 0.0304 0, .0067 0.001 0.0068 0.8873 0.0063 0.0063 0, .0102 0.0028 0, .004 0.0054
Exotic SH 261 4 0.001 0.002 0.001 0, .001 0, ,0021 0, .0034 0.001 0, .001 0.0007 0.001 0.9791 0.0011 0.001 0, .001 0.0016 0, .001 0.001
Exotic SH 262 4 0.0236 0.0035 0.0076 0, .0029 0, ,0228 0, .0118 0.022 0, .0024 0.0022 0.0079 0.818 0.0113 0.0316 0, .0032 0.0045 0, .002 0.0226
Exotic SH 263 7 0.001 0.002 0.001 0. .0031 0. ,5009 0, .001 0.002 0, .0012 0.001 0.0012 0.0102 0.001 0.0013 0, .0038 0.4582 0, .0032 0.0078
Exotic SH 264 2 0.0011 0.002 0.001 0, .0012 0, ,6721 0, .0019 0.001 0, .0013 0.001 0.0014 0.0029 0.001 0.001 0, .001 0.3058 0, .002 0.0023
Exotic SH 265 3 0.0022 0.0096 0.0024 0, .0015 0, ,3718 0, .002 0.0031 0, .0022 0.001 0.0031 0.0071 0.0019 0.0024 0, .0067 0.5751 0, .0027 0.0053
Exotic SH 266 5 0.0011 0.0031 0.001 0, .001 0, ,4978 0, .0045 0.0021 0, .002 0.0016 0.0015 0.003 0.001 0.001 0, .0014 0.4721 0, .0021 0.0037
Exotic SH 267 4 0.0206 0.0043 0.053 0, .0031 0, ,475 0, .0068 0.0024 0, .0213 0.0133 0.0076 0.0038 0.0145 0.0051 0, .0194 0.2797 0, .0391 0.0308
Exotic SH 268 5 0.0016 0.001 0.001 0. .0036 0. ,5358 0, .003 0.002 0, .0028 0.0018 0.0022 0.0028 0.0018 0.002 0, .0021 0.4301 0, .001 0.0054
Exotic SH 269 4 0.0026 0.0031 0.0018 0, .0034 0, ,6168 0, .0054 0.0024 0, .0031 0.001 0.0026 0.0057 0.002 0.002 0, .0027 0.3267 0, .0032 0.0156
Exotic SH 270 9 0.0473 0.0046 0.007 0, .002 0, ,2903 0, .0024 0.0103 0, .0031 0.0103 0.0388 0.1262 0.0065 0.0387 0, .0092 0.3427 0, .003 0.0577
Exotic SH 271 0 0.002 0.005 0.0013 0, .0102 0, ,3558 0, .0029 0.0029 0, .003 0.001 0.0022 0.0061 0.0033 0.0026 0, .0025 0.5466 0, .0013 0.0514
Exotic SH 272 1 0.0019 0.0019 0.0011 0, .0015 0, ,5542 0, .0013 0.0025 0, .002 0.0011 0.0018 0.0021 0.0012 0.001 0, .0019 0.4172 0, .0028 0.0045
Exotic SH 273 1 0.018 0.0317 0.1202 0. .0049 0. , 1133 0, .0028 0.0104 0, .0078 0.0064 0.0669 0.0078 0.0127 0.0047 0, .0297 0.5325 0, .0127 0.0176
Exotic SH 274 1 0.0045 0.0104 0.002 0, .0015 0, ,3267 0, .0064 0.0043 0, .0055 0.0018 0.0031 0.0243 0.002 0.0023 0, .0094 0.5775 0, .0069 0.0114
Exotic SH 275 0 0.0023 0.0028 0.0011 0, .0064 0, ,544 0, .0033 0.0019 0, .0028 0.001 0.002 0.006 0.0013 0.0018 0, .0025 0.4129 0, .0043 0.0036
Exotic SH 276 2 0.004 0.0079 0.0026 0. .0026 0. ,5834 0, .0038 0.0087 0, .0073 0.003 0.0111 0.0132 0.0054 0.0101 0, .0037 0.321 0, .0029 0.0093
British SH 156 9 0.0043 0.0055 0.0051 0, .0025 0, ,4419 0, .0029 0.0048 0, .004 0.001 0.0027 0.003 0.0024 0.0022 0, .0031 0.4866 0, .003 0.0249
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
British SH 157 1 0.2103 0 0049 0.0068 0 0238 0.1071 0 0029 0 0176 0 0041 0.002 0.013 0.1852 0.0434 0.0066 0 0059 0.3426 0 0077 0.0161
British SH 158 5 0.0011 0 0011 0.001 0 0022 0.6183 0 002 0 001 0 001 0.001 0.001 0.0028 0.001 0.001 0 001 0.3604 0 0012 0.0029
British SH 159 3 0.0011 0 0011 0.001 0 0027 0.6988 0 0013 0 0011 0 001 0.001 0.001 0.0038 0.001 0.001 0 001 0.2635 0 001 0.0186
British SH 160 5 0.0023 0 0066 0.001 0 0021 0.4154 0 0026 0 002 0 005 0.0012 0.0019 0.0151 0.002 0.002 0 0049 0.5274 0 0036 0.0049
British SH 161 2 0.0038 0 0025 0.0055 0 0062 0.6298 0 0044 0 0081 0 0034 0.0017 0.012 0.0099 0.0127 0.0044 0 0036 0.0022 0 0054 0.2845
British SH 162 17 0.0022 0 0029 0.0209 0 0052 0.5835 0 001 0 0139 0 0027 0.0029 0.0191 0.0049 0.036 0.002 0 0068 0.0019 0 0024 0.2917
British SH 163 15 0.0135 0 0028 0.0078 0 0055 0.5922 0 0034 0 0139 0 0037 0.0111 0.005 0.0015 0.0074 0.0029 0 0028 0.0057 0 0292 0.2916
British SH 164 8 0.0046 0 0016 0.006 0 0284 0.5898 0 0022 0 0133 0 0024 0.0054 0.0066 0.0156 0.0062 0.0038 0 0031 0.0087 0 0035 0.2988
British SH 165 15 0.1608 0 002 0.0035 0 0038 0.4208 0 0108 0 0313 0 0287 0.0118 0.1931 0.002 0.0171 0.0098 0 0042 0.0057 0 0362 0.0584
British SH 166 5 0.0057 0 008 0.0032 0 0058 0.6486 0 0062 0 0017 0 002 0.0031 0.0051 0.0058 0.0034 0.0035 0 0021 0.0043 0 0036 0.2879
British SH 167 18 0.0014 0 0012 0.0011 0 0032 0.6795 0 001 0 0018 0 0011 0.001 0.0015 0.005 0.0013 0.0017 0 0015 0.0058 0 0016 0.2903
British SH 168 15 0.0023 0 0018 0.002 0 0081 0.663 0 0049 0 0025 0 0022 0.0017 0.0029 0.0011 0.0023 0.0015 0 0014 0.0044 0 0022 0.2957
British SH 169 12 0.0059 0 0017 0.0017 0 0022 0.6667 0 005 0 0022 0 001 0.0035 0.0016 0.0047 0.0016 0.0014 0 0017 0.0025 0 0023 0.2943
British SH 170 1 0.0577 0 0023 0.0047 0 0055 0.6134 0 0012 0 0064 0 0022 0.0091 0.0197 0.0064 0.0031 0.0031 0 002 0.002 0 0051 0.2561
British SH 171 0 0.005 0 0027 0.0034 0 0023 0.6278 0 0111 0 0096 0 0014 0.0015 0.0075 0.0018 0.007 0.0027 0 0015 0.0183 0 0057 0.2907
British SH 172 2 0.0017 0 0011 0.0031 0 0128 0.6267 0 004 0 0012 0 0015 0.0017 0.0013 0.0015 0.0016 0.001 0 0017 0.0487 0 0016 0.2888
British SH 173 2 0.0036 0 004 0.0074 0 0219 0.5993 0 0111 0 0018 0 0025 0.0018 0.0079 0.001 0.0045 0.0017 0 0097 0.0261 0 005 0.2907
Scottish
Fold 5655 12 0.001 0 001 0.002 0 0021 0.8314 0 144 0 001 0 0019 0.002 0.0015 0.002 0.0023 0.0015 0 0012 0.0015 0 001 0.0026
Scottish
Fold 5669 3 0.0015 0 001 0.0011 0 001 0.9817 0 001 0 001 0 001 0.001 0.001 0.0016 0.0011 0.001 0 001 0.001 0 001 0.002
Scottish
Fold 7205 21 0.0061 0 0018 0.002 0 0031 0.8988 0 002 0 0039 0 0082 0.0032 0.005 0.0122 0.0033 0.0018 0 0377 0.002 0 0037 0.0052
Scottish
Fold 7260 6 0.005 0 0027 0.004 0 0052 0.9178 0 008 0 0069 0 0035 0.0066 0.0026 0.0082 0.0019 0.0027 0 0026 0.0081 0 0111 0.0031
Scottish
Fold 8552 16 0.0026 0 0036 0.002 0 0029 0.9355 0 0029 0 0024 0 002 0.001 0.0021 0.0288 0.0018 0.0019 0 0021 0.002 0 0028 0.0037
Scottish
Fold 9823 12 0.0018 0 001 0.001 0 0049 0.9614 0 0023 0 0034 0 0016 0.001 0.0028 0.002 0.0011 0.0015 0 0013 0.0038 0 002 0.0071
Scottish
Fold 9824 4 0.0018 0 001 0.002 0 0012 0.9613 0 0024 0 0026 0 0019 0.001 0.003 0.0047 0.0019 0.0023 0 0026 0.0019 0 0039 0.0045
Scottish
Fold 9825 4 0.0028 0 0031 0.0076 0 0011 0.8719 0 0121 0 0151 0 0111 0.0023 0.0173 0.0054 0.0065 0.005 0 0183 0.0029 0 0083 0.0092
Scottish
Fold 9826 11 0.001 0 0015 0.001 0 0076 0.9714 0 0017 0 001 0 001 0.001 0.0011 0.002 0.001 0.001 0 001 0.0035 0 0013 0.0019
JTable 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 8 10 11 12 13 14 15 16 17
Scottish
Fold 0.0016 0.0015 0.0018 0.0044 0.919 0.0123 0.0025 0.0126 0.0041 0.0035 0.0021 0.0036 0.0016 0.0075 0.0054 0.0114 0.0052
Scottish
Fold 0.0038 0.006 0.0034 0.0025 0.9008 0.0036 0.0097 0.0178 0.002 0.0052 0.0057 0.0035 0.0025 0.016 0.0025 0.0091 0.0059
Scottish
Fold 0.0061 0.0022 0.0024 0.0012 0.9544 0.002 0.003 0.002 0.002 0.003 0.0053 0.0031 0.0017 0.0026 0.0027 0.0027 0.0036
Scottish
Fold 0.0028 0.0036 0.0064 0.0037 0.9049 0.0045 0.0033 0.0067 0.0027 0.0115 0.0072 0.0137 0.0037 0.0101 0.0041 0.0029 0.0082
Scottish
Fold 0.0036 0.0018 0.0012 0.0023 0.9601 0.0017 0.0029 0.0031 0.0048 0.002 0.0036 0.002 0.0014 0.0024 0.0016 0.0025 0.003
Scottish
Fold 0.0045 0.0027 0.0023 0.0032 0.9064 0.0127 0.0113 0.0045 0.0139 0.0087 0.0033 0.0033 0.0043 0.0023 0.003 0.008 0.0056
Scottish
Fold 0.0017 0.0013 0.0017 0.0019 0.961 0.0043 0.002 0.0025 0.001 0.0023 0.0047 0.0019 0.0017 0.0033 0.0032 0.0029 0.0026
Scottish
Fold 9965 6 0.0057 0. .0017 0.0086 0 .0066 0.9227 0 .0042 0.0075 0 .003 0.0042 0. .0075 0. .0069 0, .0026 0, .0043 0, .0028 0.001 0, .0063 0, ,0044
Chartreux 1772 8 0.0011 0, .001 0.0019 0, .0016 0.969 0, .0014 0.0025 0, .0021 0.0017 0, .0017 0, ,0026 0, .0015 0, ,001 0, .0028 0.0034 0, .002 0. 0027 Chartreux 2226 2 0.001 0, .001 0.001 0, .001 0.9828 0, .001 0.001 0, .001 0.001 0, .001 0, ,0013 0, .001 0, ,001 0, .001 0.001 0, .001 0. 0019 Chartreux 2229 4 0.0034 0, .0021 0.0021 0, .001 0.949 0, .0036 0.0027 0, .0018 0.0012 0, .0024 0, ,0036 0, .003 0, ,0019 0, .003 0.0071 0, .0031 0. 009 Chartreux 2524 6 0.0023 0, .0033 0.0012 0, .0023 0.9603 0, .0026 0.0014 0, .002 0.0013 0, .0019 0, ,0086 0, .0015 0, ,0015 0, .0021 0.0019 0, .002 0, ,0038 Chartreux 2787 0 0.0046 0. .0038 0.0031 0. .0046 0.8816 0. .0076 0.0072 0. .0091 0.0011 0. .0045 0. ,0033 0, .0035 0, ,0032 0, .0216 0.021 0, .0082 0, ,0119 Chartreux 2805 10 0.0021 0, .0066 0.003 0, .0042 0.8308 0, .045 0.0029 0, .0158 0.002 0, .0029 0, ,0089 0, .0047 0, ,002 0, .0045 0.0481 0, .0086 0, ,0078 Chartreux 2813 19 0.0256 0, .0031 0.0042 0, .0083 0.8391 0, .0049 0.0044 0, .0235 0.0171 0, .0053 0, ,0123 0, .0048 0, ,0186 0, .0099 0.0028 0, .0046 0, ,0114 Chartreux 2979 2 0.0048 0, .0132 0.0033 0, .011 0.9009 0, .0078 0.0036 0, .0093 0.0058 0, .0075 0, ,003 0, .0045 0, ,0037 0, .0058 0.003 0, .0056 0, ,0072 Chartreux 4059 7 0.0048 0, .002 0.0031 0, .0119 0.767 0, .0164 0.0069 0, .0047 0.001 0, .0041 0, ,0941 0, .0025 0, ,0021 0, .0054 0.0033 0, .0076 0, ,063 Chartreux 4063 1 0.0081 0. .0036 0.0024 0. .0024 0.7695 0. .0029 0.0024 0. .0124 0.002 0. .0026 0. ,009 0, .0033 0, ,0016 0, .0553 0.0047 0, .0021 0, , 1157 Chartreux 5606 0 0.0028 0, .0027 0.0107 0, .0281 0.8417 0, .0139 0.003 0, .0046 0.0018 0, .0044 0, ,0282 0, .0049 0, ,0044 0, .006 0.0058 0, .0054 0, ,0317 Chartreux 5609 1 0.005 0, .0154 0.003 0, .0027 0.7679 0, .003 0.0048 0, .0075 0.0036 0, .0083 0, ,0259 0, .0073 0, ,0044 0, .0048 0.0036 0, .017 0. 1158 Chartreux 5611 0 0.002 0, .0053 0.003 0, .0018 0.8149 0, .0021 0.0035 0, .002 0.0019 0, .0027 0, ,0043 0, .0027 0, ,002 0, .0029 0.0034 0, .0054 0. 1401 American
SH 143 2 0.002 0. .0019 0.0025 0 .0865 0.7379 0 .0022 0.0073 0 .0019 0.001 0. .0038 0. ,0056 0, .0019 0, .0012 0, .0095 0.0024 0, .002 0, ,1304
American
SH 144 0 0.0264 0, .0038 0.0049 0 .0021 0.682 0 .0037 0.0033 0 .005 0.001 0, .0035 0, ,0418 0, .0094 0, .0028 0, .0124 0.002 0, .0111 0, ,1848
American
SH 145 0 0.0095 0, .0018 0.0019 0 .0047 0.6966 0 .0041 0.0025 0 .0054 0.0017 0, .0028 0, ,0106 0, .0051 0, .001 0, .0033 0.0013 0, .01 0, ,2377
JTable 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 8 10 11 12 13 14 15 16 17
American
SH 0.002 0.0063 0.0043 0.0029 0.8084 0.002 0.0149 0.0036 0.002 0.003 0.0077 0.0033 0.0043 0.0055 0.008 0.0035 0.1183
American
SH 0.0011 0.004 0.0019 0.0015 0.7862 0.0017 0.0052 0.0021 0.0011 0.0015 0.0231 0.0021 0.0019 0.0023 0.002 0.002 0.1603
American
SH 0.0116 0.0014 0.0101 0.0028 0.7964 0.006 0.0052 0.0071 0.007 0.0051 0.0078 0.0041 0.0051 0.003 0.0081 0.0035 0.1157
American
SH 0.0045 0.001 0.0035 0.0492 0.764 0.0014 0.0062 0.0053 0.0022 0.005 0.0123 0.0041 0.0084 0.0056 0.002 0.0014 0.1239
American
SH 0.0059 0.0082 0.0032 0.0024 0.8816 0.004 0.0032 0.0039 0.001 0.0021 0.0205 0.0037 0.0061 0.0052 0.0028 0.002 0.0442
American
SH 0.0073 0.0045 0.0036 0.0012 0.7815 0.0014 0.0028 0.0046 0.001 0.0021 0.0082 0.0043 0.0029 0.0582 0.0032 0.0055 0.1077
American
SH 0.0171 0.025 0.0048 0.0077 0.7794 0.0292 0.0055 0.0063 0.0027 0.0027 0.0329 0.0057 0.0066 0.0063 0.0342 0.007 0.0269
American
SH 0.002 0.0078 0.0022 0.0032 0.4852 0.0031 0.014 0.0038 0.2669 0.0034 0.0053 0.0055 0.0033 0.0047 0.0047 0.0056 0.1793
American
SH 0.0019 0.001 0.002 0.002 0.3294 0.0021 0.0019 0.0021 0.4475 0.0019 0.0013 0.0019 0.0012 0.0031 0.0024 0.0016 0.1967
American
SH 0.0018 0.0018 0.0015 0.0018 0.5073 0.003 0.0036 0.002 0.2659 0.0019 0.001 0.0018 0.0018 0.0024 0.0025 0.0025 0.1975
American
SH 2259 10 0.0019 0, .002 0.0019 0, .0017 0.4169 0, .0048 0, ,0023 0, .0039 0, ,3483 0, .0026 0, ,0036 0, .0015 0.0014 0, .002 0.0089 0, .0035 0. 1928
Sphynx 277 4 0.001 0, .0011 0.001 0, .001 0.3356 0, .0016 0, ,0016 0, .0018 0, 4479 0, .0013 0, ,001 0, .001 0.001 0, .0017 0.0025 0, .0011 0. 1978
Sphynx 278 5 0.001 0, .001 0.0014 0, .001 0.4198 0, .0026 0, ,0018 0, .0017 0, ,3616 0, .0013 0, ,001 0, .0012 0.0011 0, .0017 0.0025 0, .0019 0. 1973
Sphynx 279 0 0.0017 0, .0012 0.0016 0, .001 0.3979 0, .0051 0, ,0037 0, .003 0, ,3736 0, .0018 0, ,001 0, .0021 0.0026 0, .0028 0.0024 0, .0025 0. 196
Sphynx 280 6 0.001 0. .001 0.001 0. .001 0.4469 0. .0015 0. ,001 0, .0015 0, ,3394 0, .001 0, ,0012 0, .001 0.001 0, .0012 0.0034 0, .0012 0. 1956
Sphynx 281 14 0.0018 0, .0013 0.0013 0, .001 0.3006 0, .0037 0, ,0018 0, .0021 0, ,4772 0, .0017 0, ,001 0, .0012 0.0017 0, .001 0.003 0, .0014 0. 1982
Sphynx 282 8 0.0016 0, .0018 0.0021 0, .0022 0.3815 0, .001 0, ,0022 0, .0028 0, ,399 0, .0022 0, ,0021 0, .0012 0.0021 0, .003 0.0028 0, .0033 0. 1892
Sphynx 283 1 0.0016 0, .0014 0.001 0, .0015 0.4405 0, .0022 0, ,0025 0, .0023 0, ,3356 0, .0017 0, ,001 0, .0018 0.0012 0, .0027 0.0037 0, .0018 0. 1975
Sphynx 284 14 0.0024 0, .001 0.0018 0, .0018 0.3368 0, .0043 0, ,002 0, .0044 0, ,4309 0, .0021 0, ,0017 0, .0019 0.0024 0, .0025 0.0031 0, .0018 0. 1991
Sphynx 285 4 0.0018 0. .0018 0.0028 0. .0021 0.5105 0. .0021 0. ,0051 0, .0059 0, ,2202 0, .0033 0, ,0024 0, .0024 0.0023 0, .0279 0.0108 0, .0052 0. 1934
Sphynx 286 22 0.0033 0, .0035 0.0062 0, .0018 0.5472 0, .0085 0, ,0109 0, .0038 0, , 1648 0, .0035 0, ,0018 0, .0034 0.0052 0, .0033 0.0282 0, .0106 0. 194
Sphynx 287 9 0.008 0, .0073 0.0055 0, .0028 0.4222 0, .0031 0, ,0277 0, .0152 0, 2448 0, .0076 0, ,002 0, .0088 0.0084 0, .0592 0.0109 0, .009 0. 1575
Sphynx 288 2 0.001 0. .001 0.001 0. .0018 0.4424 0. .0012 0. ,002 0, .0021 0, ,3381 0, .0014 0, ,001 0, .0015 0.0011 0, .0016 0.0028 0, .0018 0. 1982
Sphynx 289 1 0.0023 0, .001 0.002 0, .0033 0.4343 0, .0022 0, ,0025 0, .0031 0, ,3368 0, .0021 0, ,0046 0, .0019 0.0018 0, .0024 0.0036 0, .0028 0. 1933
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Sphynx 290 2 0.019 0.0033 0.0051 0.0041 0.0021 0.003 0.0032 0.0052 0.9015 0.0065 0.0099 0.0064 0.0065 0.0065 0.0019 0.0064 0.0094
Sphynx 291 2 0.0034 0.008 0.011 0.1264 0.0022 0.0035 0.0056 0.1043 0.6641 0.0092 0.0028 0.0064 0.0046 0.0144 0.0095 0.0072 0.0174
Sphynx 292 1 0.0114 0.0097 0.0121 0.0037 0.0093 0.0075 0.0074 0.0032 0.8437 0.0103 0.0103 0.0093 0.0068 0.0056 0.004 0.0273 0.0183
Sphynx 293 1 0.0074 0.0929 0.0113 0.0109 0.0029 0.0046 0.0032 0.0129 0.75 0.0113 0.0047 0.0049 0.0167 0.0166 0.0061 0.0101 0.0336
Japanese
BT 1949 6 0.0045 0.0053 0.0168 0.0019 0.0016 0.0019 0.0046 0.0039 0.8907 0.005 0.0051 0.0212 0.0157 0.0053 0.0042 0.007 0.0053
Japanese
BT 1966 4 0.0064 0.0179 0.0132 0.0025 0.0053 0.0055 0.0068 0.0134 0.7273 0.0113 0.0109 0.1083 0.0215 0.0158 0.0022 0.0035 0.0282
Japanese
BT 2661 0 0.0199 0.0014 0.0037 0.0137 0.0015 0.0025 0.0029 0.0088 0.9117 0.0036 0.0016 0.0075 0.0022 0.0023 0.001 0.0023 0.0134
Japanese
BT 2663 4 0.0038 0.0013 0.0014 0.0017 0.0017 0.001 0.0024 0.0017 0.9681 0.001 0.004 0.0017 0.002 0.002 0.002 0.0021 0.0021
Japanese
BT 2666 4 0.0222 0.0022 0.0155 0.0039 0.0019 0.002 0.0043 0.0111 0.8141 0.0165 0.0028 0.0173 0.0376 0.0033 0.0075 0.0109 0.0269
Japanese
BT 2668 0 0.044 0.0029 0.0065 0.0095 0.005 0.0037 0.0064 0.0082 0.8562 0.0077 0.0027 0.0071 0.0053 0.0093 0.0055 0.006 0.0141
Japanese
BT 2973 3 0.0102 0.006 0.0298 0.0063 0.0133 0.0044 0.0068 0.0068 0.8237 0.0071 0.0017 0.0039 0.0049 0.0256 0.0061 0.0055 0.0379
Japanese
BT 3324 1 0.0518 0.0049 0.0084 0.0028 0.0024 0.0124 0.0151 0.0103 0.7868 0.0047 0.0053 0.0107 0.0076 0.0125 0.0026 0.052 0.0095
Japanese
BT 3355 2 0.0061 0.0017 0.0048 0.0013 0.001 0.0018 0.0017 0.0025 0.9616 0.0026 0.0017 0.0027 0.0028 0.0019 0.001 0.0019 0.0029
Japanese
BT 3356 3 0.0293 0.0032 0.0062 0.0035 0.0023 0.0037 0.0037 0.006 0.8994 0.0032 0.0036 0.0069 0.0082 0.0042 0.0028 0.0056 0.0083
Japanese
BT 3523 1 0.0032 0.0036 0.008 0.1776 0.0243 0.0097 0.0023 0.0055 0.694 0.009 0.0107 0.0058 0.0046 0.0114 0.0063 0.0058 0.0181
Japanese
BT 3621 12 0.001 0.001 0.002 0.9746 0.001 0.001 0.0017 0.0028 0.001 0.0017 0.001 0.0012 0.0017 0.0028 0.001 0.003 0.0015
Japanese
BT 3622 6 0.0011 0.001 0.001 0.9805 0.0011 0.001 0.001 0.0011 0.001 0.001 0.0028 0.0011 0.0017 0.0012 0.001 0.001 0.0014
Japanese
BT 3673 0 0.0088 0.0025 0.0029 0.9363 0.0047 0.0081 0.003 0.0051 0.002 0.0028 0.0039 0.0029 0.002 0.002 0.0048 0.0041 0.0041
Japanese
BT 3691 11 0.001 0.001 0.001 0.978 0.0023 0.002 0.001 0.0018 0.001 0.001 0.0011 0.0012 0.001 0.0013 0.0023 0.0015 0.0015
Japanese 3693 8 0.0043 0.001 0.0049 0.8894 0.0014 0.0027 0.0067 0.0491 0.0067 0.005 0.001 0.0062 0.0081 0.0033 0.002 0.002 0.0062
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
BT
Japanese
BT 4027 23 0.003 0. .0056 0.0127 0. .9234 0.0047 0. .0103 0. .0022 0, .003 0, ,0046 0, .0031 0, ,0056 0, .004 0.005 0, .0012 0.004 0, .0041 0.0035
Japanese
BT 4030 14 0.0019 0, .0014 0.0019 0, .9649 0.0032 0, .004 0, ,0027 0, .003 0, ,001 0, .0021 0, ,002 0, .0013 0.0015 0, .002 0.003 0, .002 0.0021
Japanese
BT 4043 14 0.0024 0, .0014 0.0028 0, .9753 0.001 0, .0011 0, ,001 0, .0016 0, ,001 0, .0016 0, ,001 0, .0027 0.002 0, .0011 0.0012 0, .001 0.0018
Cornish
Rex 2497 14 0.0042 0, .002 0.0029 0, .9274 0.0021 0, .0053 0, ,0049 0, .0094 0, ,0011 0, .0028 0, ,0079 0, .0073 0.0033 0, .0037 0.0041 0, .0084 0.0032 Cornish
Rex 2863 8 0.0068 0. .002 0.0077 0. .925 0.0018 0. .006 0. ,006 0, .0074 0, ,0027 0, .0038 0, ,0027 0, .004 0.0057 0, .0046 0.0032 0, .0062 0.0044 Cornish
Rex 2872 5 0.0026 0, .0046 0.0042 0, .9097 0.0056 0, .003 0, ,0045 0, .0052 0, ,0181 0, .0089 0, ,0021 0, .0045 0.0096 0, .0023 0.0057 0, .0047 0.0047 Cornish
Rex 3283 16 0.0126 0, .03 0.0028 0, 7524 0.0036 0, .002 0, ,0223 0, .0107 0, ,0055 0, .0402 0, ,0064 0, .0072 0.0125 0, .0416 0.0056 0, .0255 0.0191 Cornish
Rex 3306 0 0.0124 0, .0132 0.0132 0, .7913 0.0172 0, .0064 0, ,0151 0, .0077 0, ,0012 0, .0246 0, ,0109 0, .0351 0.0106 0, .0036 0.0023 0, .0094 0.0258 Cornish
Rex 3931 12 0.0301 0, .0025 0.0055 0, .008 0.5654 0, .0078 0, ,0166 0, .0059 0, ,0065 0, .0108 0, ,0034 0, .0185 0.0032 0, .0036 0.0066 0, .0223 0.2832 Cornish
Rex 3955 4 0.0039 0. .0181 0.0056 0. .8535 0.0047 0. .0041 0. ,0063 0, .0122 0, ,0055 0, .0098 0, ,0016 0, .0038 0.0084 0, .0112 0.0358 0, .0074 0.0081 Cornish
Rex 3992 2 0.0021 0, .001 0.001 0, .9741 0.0018 0, .0021 0, ,0015 0, .0017 0, ,001 0, .002 0, ,002 0, .0015 0.0015 0, .002 0.001 0, .002 0.0017 Cornish
Rex 5790 1 0.002 0, .0023 0.0022 0, .9484 0.0025 0, .002 0, ,0046 0, .0048 0, ,0032 0, .0038 0, ,0017 0, .0022 0.003 0, .0044 0.0021 0, .0075 0.0033 Cornish
Rex 7031 3 0.0021 0, .001 0.0028 0, .9665 0.0018 0, .002 0, ,0018 0, .002 0, ,0012 0, .0028 0, ,0035 0, .002 0.003 0, .0017 0.0015 0, .0022 0.0021 Cornish
Rex 7036 15 0.0053 0, .0082 0.1478 0, .0082 0.0026 0, .0031 0, ,0135 0, .008 0, ,0051 0, .0287 0, ,0032 0, .6506 0.0242 0, .0132 0.0062 0, .0663 0.0059 Cornish
Rex 8528 2 0.0024 0. .003 0.2225 0. .001 0.0011 0. .002 0. ,0092 0, .005 0, ,001 0, .0203 0, ,0025 0, .6794 0.0339 0, .005 0.0017 0, .0035 0.0065 Cornish
Rex 8529 6 0.0034 0, .0197 0.1784 0, .0015 0.0065 0, .0213 0, ,0166 0, .0034 0, ,0055 0, .0052 0, ,0136 0, .6886 0.006 0, .0051 0.009 0, .012 0.0042 Cornish
Rex 8530 2 0.003 0, .0029 0.1972 0, .0014 0.001 0, .0021 0, ,0042 0, .002 0, ,001 0, .0047 0, ,001 0, .7671 0.0038 0, .0022 0.001 0, .0022 0.0032
J able 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Cornish
Rex 8543 10 0.0069 0 0021 0.0046 0 0138 0.001 0 005 0 002 0 8884 0 0044 0 037 0 0017 0 0057 0.0055 0 0034 0 0014 0 0145 0 0026
Ragdoll 7429 4 0.0035 0 0033 0.1846 0 0064 0.001 0 0034 0 0098 0 0119 0 0026 0 0084 0 002 0 7138 0.0101 0 0083 0 0034 0 0075 0 02
Ragdoll 8362 2 0.0059 0 0021 0.1897 0 0033 0.0018 0 0031 0 0024 0 0092 0 0012 0 0054 0 0043 0 7526 0.0041 0 0033 0 0013 0 0057 0 0046
Ragdoll 8366 0 0.0072 0 1174 0.0959 0 0013 0.0014 0 0023 0 003 0 0026 0 0025 0 0052 0 003 0 5522 0.1919 0 003 0 001 0 0031 0 007
Ragdoll 8367 2 0.0059 0 0028 0.1976 0 0022 0.0043 0 0029 0 0078 0 0042 0 0011 0 0267 0 0028 0 7227 0.0049 0 0049 0 001 0 0041 0 004
Ragdoll 8368 4 0.0035 0 0147 0.1672 0 0012 0.0051 0 0111 0 004 0 0029 0 0027 0 0047 0 0045 0 7554 0.0079 0 0037 0 0022 0 0037 0 0055
Ragdoll 8372 2 0.0402 0 021 0.1437 0 002 0.0033 0 0063 0 0138 0 0148 0 0028 0 0163 0 0167 0 571 0.1194 0 0059 0 0054 0 0062 0 0112
Ragdoll 8377 3 0.0132 0 0058 0.0606 0 0084 0.0039 0 018 0 008 0 0067 0 0018 0 0082 0 0054 0 5088 0.2876 0 0196 0 0061 0 0047 0 0332
Ragdoll 9292 0 0.0051 0 0028 0.1696 0 0022 0.0013 0 0053 0 0024 0 0046 0 0038 0 006 0 0025 0 7707 0.0028 0 0089 0 0024 0 0023 0 0073
Ragdoll 9295 0 0.0045 0 002 0.0046 0 0015 0.0013 0 002 0 0055 0 0069 0 001 0 0066 0 0024 0 0034 0.9344 0 0142 0 002 0 0039 0 0038
Ragdoll 9299 1 0.0027 0 0062 0.0081 0 001 0.0028 0 0017 0 004 0 002 0 0021 0 0056 0 0079 0 0064 0.9385 0 0029 0 001 0 002 0 0051
Ragdoll 9300 0 0.0039 0 0298 0.0234 0 1373 0.0021 0 0043 0 0089 0 0129 0 001 0 3176 0 0094 0 0849 0.3055 0 0124 0 0106 0 0184 0 0175
Ragdoll 9301 2 0.0226 0 1856 0.0085 0 1741 0.0082 0 003 0 0082 0 0167 0 002 0 0135 0 0061 0 0203 0.4666 0 0228 0 0091 0 0157 0 0171
Ragdoll 9302 2 0.003 0 0023 0.0148 0 001 0.001 0 0027 0 0111 0 0089 0 0021 0 1519 0 002 0 038 0.6837 0 0467 0 0013 0 0044 0 025
Ragdoll 9304 2 0.0125 0 003 0.0083 0 0011 0.003 0 0142 0 0049 0 0067 0 002 0 0268 0 002 0 0047 0.8808 0 0135 0 0038 0 0036 0 0091
Ragdoll 9305 2 0.0136 0 0032 0.0076 0 0027 0.002 0 0046 0 0143 0 0243 0 0037 0 0036 0 0025 0 0051 0.8859 0 0101 0 0021 0 0083 0 0065
Maine
Coon 2950 1 0.0041 0 0033 0.0417 0 0174 0.0048 0 0079 0 0234 0 0356 0 0061 0 0324 0 0051 0 0254 0.6881 0 0283 0 0035 0 0457 0 0271
Maine
Coon 2959 2 0.0642 0 005 0.0807 0 0107 0.0049 0 0049 0 0179 0 0069 0 0341 0 0156 0 0028 0 0715 0.6367 0 0136 0 0046 0 0105 0 0155
Maine
Coon 3304 9 0.0088 0 002 0.0151 0 0125 0.0046 0 0102 0 0305 0 0696 0 0035 0 0272 0 002 0 0108 0.7572 0 0116 0 0037 0 0158 0 0148
Maine
Coon 3311 6 0.0035 0 0027 0.0069 0 0058 0.0021 0 005 0 0027 0 0067 0 0083 0 0052 0 002 0 0046 0.9005 0 0148 0 0022 0 0039 0 0231
Coon 3495 3 0.0221 0 006 0.1272 0 0179 0.0087 0 0033 0 0572 0 0087 0 002 0 0563 0 0139 0 1512 0.4019 0 0177 0 0072 0 0685 0 0303
Maine
Coon 3925 2 0.002 0 002 0.0049 0 0401 0.0084 0 0036 0 0107 0 0037 0 0052 0 003 0 0268 0 0037 0.8522 0 0074 0 0056 0 0103 0 0105
Maine
Coon 3941 2 0.008 0 0075 0.0086 0 0021 0.0043 0 006 0 0066 0 0036 0 0027 0 0055 0 0027 0 0108 0.8893 0 0213 0 0032 0 0039 0 0139
Maine
Coon 9198 14 0.0021 0 0016 0.0082 0 002 0.001 0 002 0 0066 0 0052 0 0022 0 0591 0 001 0 0047 0.8941 0 0011 0 001 0 002 0 0061
Maine
Coon 9775 2 0.0042 0 0091 0.0186 0 028 0.0035 0 0075 0 0223 0 0052 0 001 0 0329 0 0032 0 0086 0.8173 0 0145 0 0025 0 008 0 0135
J able 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Maine
Coon 10662 16 0.0047 0, .0044 0.002 0, .001 0.0018 0, .0017 0, ,0034 0, .0069 0, ,2196 0, .0031 0, ,0023 0, .0028 0.6859 0, .0049 0, ,002 0, .0029 0, ,0506
IvldlNc
Coon 11544 8 0.0036 0, .0041 0.0079 0, .0025 0.0026 0, .0028 0, ,0173 0, .0113 0, ,002 0, .0074 0, ,0034 0, .0044 0.9072 0, .011 0, ,0034 0, .0034 0, ,0057 aine
Coon 217 14 0.0534 0, .005 0.0128 0, .1373 0.0072 0, .002 0, ,0071 0, .0107 0, ,0036 0, .0103 0, ,0021 0, .0139 0.3961 0, .161 0, ,0107 0, .0066 0, ,1601
Maine
Coon 218 3 0.0027 0, .0258 0.0107 0, .0061 0.0018 0, .0011 0, ,0054 0, .0536 0, ,0237 0, .0096 0, ,003 0, .0071 0.5809 0, .0884 0, ,0025 0, .0064 0, ,1711
Maine
Coon 219 9 0.0044 0, .0243 0.0025 0, .0111 0.0033 0, .0057 0, ,0071 0, .0067 0, ,0027 0, .0096 0, ,0102 0, .004 0.648 0, .0881 0, ,0023 0, .0044 0, ,1657
Maine
Coon 220 1 0.062 0, .1609 0.012 0, .0244 0.0057 0, .0119 0, ,0034 0, .0882 0, ,0038 0, .0109 0, ,0313 0, .0126 0.1559 0, .2167 0, ,0036 0, .0021 0, ,1946
Maine
Coon 221 8 0.004 0, .0133 0.011 0, .1828 0.0124 0, .0075 0, ,0034 0, .0125 0, , 1474 0, .0048 0, ,0109 0, .0093 0.3585 0, .0705 0, ,002 0, .0109 0, ,1387 iv ftiaine
Coon 222 5 0.0061 0. .0081 0.0054 0. .0496 0.0206 0. .0036 0. ,0094 0, .0155 0, ,002 0, .019 0, ,0236 0, .0065 0.5996 0, .0772 0, ,0039 0, .0039 0, ,146 iviaine
Coon 223 20 0.0045 0, .0031 0.0045 0, .0054 0.0056 0, .0059 0, ,0212 0, .1216 0, ,0018 0, .5962 0, ,0023 0, .0044 0.0321 0, .0775 0, ,0037 0, .0119 0, ,0983
Maine
Coon 224 6 0.0032 0, .0275 0.0028 0, .0152 0.0035 0, .0018 0, ,0043 0, .0078 0, ,002 0, .0096 0, ,0071 0, .0069 0.6352 0, .1041 0, ,0038 0, .0034 0, ,1618
Abyssinian 110 13 0.0709 0. .01 0.041 0. .0175 0.0272 0. .0456 0. ,0126 0, .0118 0, ,0042 0, .0088 0, ,0875 0, .0571 0.1872 0, .2001 0, ,0201 0, .0051 0, , 1932
Abyssinian 111 26 0.0031 0, .0401 0.0095 0, .0534 0.0012 0, .0055 0, ,0028 0, .02 0, ,0071 0, .0184 0, ,0018 0, .0209 0.4782 0, .116 0, ,0016 0, .0026 0, ,2179
Abyssinian 112 10 0.0036 0, .0064 0.0054 0, .0068 0.0077 0, .0258 0, ,0035 0, .0057 0, ,0027 0, .007 0, ,004 0, .0936 0.4985 0, .1167 0, ,0097 0, .0027 0, ,2003
Abyssinian 113 10 0.0051 0, .0088 0.0081 0, .0027 0.0034 0, .0023 0, ,0037 0, .0137 0, ,0222 0, .0075 0, ,0017 0, .0176 0.4555 0, .2409 0, ,0036 0, .0034 0, , 1997
Abyssinian 114 1 0.0069 0, .0056 0.0041 0, .0065 0.0058 0, .0085 0, ,0046 0, .0051 0, ,0963 0, .0047 0, ,0042 0, .0076 0.5434 0, .0907 0, ,0113 0, .0039 0, , 1909
Abyssinian 115 18 0.015 0. .0279 0.0223 0. .004 0.0109 0. .0054 0. ,0042 0, .0324 0, ,003 0, .0899 0, .01 0, .0574 0.0087 0, .0077 0, ,0147 0, .6734 0, ,013
Abyssinian 116 15 0.0029 0, .0072 0.0237 0, .0019 0.0027 0, .0088 0, ,005 0, .0044 0, ,0179 0, .0079 0, ,002 0, .01 0.0065 0, .005 0, ,0063 0, .8827 0, ,0051
Abyssinian 117 5 0.0025 0, .0018 0.002 0, .0018 0.001 0, .001 0, ,002 0, .0026 0, ,0018 0, .0019 0, ,0012 0, .002 0.0018 0, .0039 0, ,001 0, .9701 0, ,0016
Abyssinian 118 4 0.0023 0, .001 0.0011 0, .0042 0.0022 0, .0068 0, ,0046 0, .0049 0, ,0011 0, .0024 0, ,0021 0, .0012 0.001 0, .0049 0, ,0531 0, .9052 0, ,0019
Abyssinian 119 5 0.0609 0, .0099 0.0263 0, .0043 0.0555 0, .0154 0, ,0129 0, .007 0, ,0033 0, .0498 0, ,0337 0, .0114 0.0106 0, .0103 0, ,0093 0, .6646 0, ,0149
Abyssinian 120 10 0.0098 0. .0054 0.0051 0. .0052 0.0104 0. .1715 0. ,0071 0, .0035 0, ,0091 0, .0044 0, ,0174 0, .0068 0.0031 0, .0036 0, ,0015 0, .73 0, ,0062
Abyssinian 121 2 0.0044 0, .002 0.0083 0, .0078 0.002 0, .002 0, ,0059 0, .0111 0, ,002 0, .0105 0, ,002 0, .0227 0.0036 0, .0038 0, ,0023 0, .9031 0, ,0064
Abyssinian 122 4 0.0048 0, .0033 0.0021 0, .0057 0.0157 0, .0728 0, ,0187 0, .0112 0, ,001 0, .0077 0, ,0218 0, .0025 0.002 0, .0097 0, ,003 0, .8142 0, ,0038
Abyssinian 123 18 0.016 0. .01 0.0047 0. .002 0.0686 0. .0075 0. ,0511 0, .0213 0, ,0053 0, .026 0, ,0051 0, .0213 0.0277 0, .0106 0, ,0097 0, .6973 0, ,0157
Abyssinian 6934 9 0.0028 0, .0032 0.0069 0, .0048 0.0035 0, .008 0, ,005 0, .0069 0, ,0016 0, .0166 0, ,0968 0, .0036 0.0062 0, .0057 0, ,0044 0, .821 0, ,003
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Siberian 3273 10 0.0026 0, .0125 0.0022 0, .0033 0, ,0058 0, .1109 0, ,0121 0, .0111 0.0076 0.0022 0.002 0.0054 0.0028 0.0035 0.0047 0.8075 0.0038
Siberian 4593 6 0.002 0, .0102 0.0053 0, .0037 0, ,0031 0, .002 0, ,0094 0, .0068 0.0021 0.0052 0.0035 0.0042 0.0032 0.004 0.003 0.9295 0.0028
Siberian 4829 6 0.0053 0. .002 0.0046 0. .0029 0. ,0017 0, .0032 0, ,0104 0, .0073 0.002 0.02 0.0127 0.011 0.0077 0.0039 0.002 0.9003 0.003
Siberian 4928 6 0.0188 0, .008 0.1093 0, .0067 0, ,0264 0, .0181 0, ,0125 0, .0057 0.0034 0.0221 0.0127 0.1924 0.0034 0.0104 0.002 0.5319 0.0161
Siberian 4930 14 0.0446 0, .006 0.0065 0, .002 0, ,0033 0, .0031 0, ,0036 0, .0058 0.0041 0.0031 0.0016 0.0034 0.0071 0.0048 0.0093 0.8871 0.0047
Siberian 5101 9 0.0019 0, .0058 0.0039 0, .002 0, ,001 0, .0019 0, ,0054 0, .0027 0.002 0.0034 0.0081 0.004 0.009 0.0032 0.0027 0.9403 0.0027
Siberian 5105 2 0.0043 0, .0077 0.0192 0, .0121 0, ,0069 0, .0091 0, ,0123 0, .0085 0.0038 0.0077 0.0114 0.0095 0.0064 0.0104 0.0272 0.8356 0.0079
Siberian 5107 6 0.0046 0, .0035 0.0037 0, .0074 0, , 1061 0, .0989 0, ,0121 0, .0067 0.0016 0.0057 0.0687 0.0022 0.002 0.0032 0.0051 0.6631 0.0055
Siberian 5110 9 0.0601 0, .0042 0.2709 0, .0029 0, ,0016 0, .0923 0, ,0033 0, .0052 0.0021 0.0294 0.002 0.2111 0.0045 0.0047 0.0056 0.2615 0.0386
Siberian 5118 6 0.0041 0, .0012 0.8928 0, .0045 0, ,003 0, .0022 0, ,0049 0, .0063 0.0043 0.0033 0.0073 0.0037 0.0023 0.0525 0.0012 0.003 0.0034
Siberian 5120 18 0.0175 0. .0125 0.8265 0. .0026 0. ,0019 0, .0044 0, ,0124 0, .0084 0.0037 0.012 0.0029 0.0488 0.0159 0.0029 0.002 0.0198 0.0059
Siberian 5632 12 0.0041 0, .0084 0.6525 0, .0155 0, ,0038 0, .0165 0, ,0047 0, .0039 0.0164 0.0346 0.0076 0.1406 0.0655 0.0034 0.0041 0.0106 0.0077
Siberian 6474 18 0.0033 0, .0037 0.8813 0, .0037 0, ,0011 0, .0021 0, ,0028 0, .0059 0.0015 0.0065 0.002 0.0108 0.0093 0.0138 0.002 0.0455 0.0046
Siberian 11562 2 0.0066 0, .0021 0.7764 0, .002 0, ,0146 0, .0046 0, ,0147 0, .0324 0.0307 0.043 0.0075 0.0171 0.0078 0.0077 0.0071 0.0073 0.0184
Siberian 11582 10 0.0083 0, .0034 0.8619 0, .0091 0, ,0021 0, .0048 0, ,0033 0, .039 0.0051 0.0078 0.0032 0.0109 0.0151 0.0062 0.0037 0.0064 0.0097
Siberian 11559 24 0.0029 0. .0021 0.9554 0. .0011 0. ,001 0, .0022 0, ,0034 0, .004 0.0026 0.0039 0.0016 0.0034 0.0031 0.0073 0.001 0.0024 0.0026
Siberian 11560 1 0.0574 0, .0134 0.5024 0, .0201 0, ,021 0, .008 0, ,0077 0, .0268 0.0747 0.1203 0.0138 0.0523 0.0145 0.009 0.0127 0.0066 0.0391
Norwegian
FC 2942 2 0.0037 0.0055 0.8857 0.0045 0.0023 0.0015 0.0051 0.011 0.004 0.0109 0.0019 0.029 0.0113 0.0034 0.0046 0.0059 0.0097
Norwegian
FC 3610 1 0.0047 0.0128 0.9192 0.0018 0.0019 0.0024 0.0137 0.0054 0.0012 0.0058 0.0025 0.0068 0.0096 0.0031 0.0012 0.0045 0.0034
Norwegian
FC 3611 1 0.0189 0.0207 0.8418 0.0025 0.0023 0.0046 0.0075 0.0036 0.0017 0.0094 0.0036 0.0248 0.0053 0.012 0.002 0.0356 0.0037
Norwegian
FC 3612 10 0.004 0.0076 0.9207 0.0052 0.0018 0.002 0.002 0.0024 0.0047 0.0065 0.001 0.0128 0.0144 0.0021 0.0048 0.0027 0.0053
Norwegian
FC 3617 1 0.0072 0.0024 0.3296 0.0089 0.0128 0.0027 0.0114 0.009 0.0075 0.3362 0.0073 0.0719 0.0134 0.0385 0.0118 0.0059 0.1235
Norwegian
FC 3661 2 0.0027 0.0022 0.9535 0.003 0.0019 0.002 0.0044 0.0028 0.0031 0.0029 0.0019 0.0029 0.0028 0.0051 0.0033 0.0025 0.003
Norwegian
FC 4815 0 0.0277 0.0148 0.0825 0.0287 0.0057 0.0475 0.0536 0.1629 0.0088 0.1034 0.0073 0.0381 0.085 0.1571 0.0171 0.0787 0.0809
Norwegian
FC 4816 0 0.0029 0.0025 0.5885 0.0041 0.002 0.013 0.0123 0.0038 0.0026 0.0809 0.0034 0.1778 0.005 0.0033 0.0048 0.0617 0.0314
Norwegian
FC 6004 2 0.1582 0.0155 0.4053 0.0133 0.0316 0.002 0.0185 0.0284 0.0547 0.0687 0.0162 0.037 0.0233 0.0176 0.0131 0.0324 0.0644
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Norwegian
FC 6932 8 0.0414 0, .0475 0.6597 0, .0015 0, ,0023 0, .0054 0, ,0117 0, .0096 0.1112 0.0152 0.002 0.0065 0.0059 0, .0342 0.0085 0, .0309 0.0066
Norwegian
FC 9321 7 0.007 0, .0068 0.7523 0, .005 0, ,0028 0, .0036 0, ,0058 0, .0099 0.013 0.1302 0.0032 0.0248 0.0086 0, .0031 0.002 0, .009 0.0128
Norwegian
FC 10367 0 0.0021 0, .0042 0.1867 0, .0035 0, ,002 0, .0011 0, ,0071 0, .003 0.0026 0.0129 0.0036 0.7461 0.0053 0, .0107 0.0025 0, .0024 0.0042
Norwegian
FC 10682 18 0.0075 0, .002 0.3517 0, .0028 0, ,0046 0, .0031 0, ,0078 0, .0359 0.0046 0.2105 0.0095 0.1456 0.0164 0, .0196 0.0081 0, .0033 0.1671
Norwegian
FC 11548 11 0.0031 0, .0014 0.003 0, .0019 0, ,001 0, .0027 0, ,002 0, .9126 0.0042 0.0426 0.0015 0.0031 0.0041 0, .0039 0.001 0, .0095 0.0024
Norwegian
FC 242 8 0.0056 0, .0137 0.0239 0, .0149 0, ,0031 0, .0072 0, ,0096 0, .396 0.0014 0.1297 0.0153 0.0735 0.147 0, .0118 0.0067 0, .0047 0.1359
Manx 2928 18 0.0041 0, .0073 0.0409 0, .002 0, ,002 0, .0254 0, ,0123 0, .23 0.0055 0.3063 0.0021 0.0588 0.1812 0, .0041 0.0028 0, .0121 0.1031
Manx 2980 9 0.0179 0, .0211 0.1271 0, .0136 0, ,0062 0, .0156 0, ,016 0, .042 0.0067 0.2808 0.0096 0.202 0.0118 0, .0233 0.007 0, .0075 0.1918
Manx 3926 19 0.0185 0, .0029 0.3123 0, .0089 0, ,001 0, .0028 0, ,0046 0, .1822 0.003 0.1788 0.001 0.0926 0.0051 0, .0099 0.001 0, .0029 0.1725
Manx 4378 1 0.0097 0. .0176 0.1723 0. .0035 0. ,0035 0, .0039 0, ,0051 0, .0076 0.0034 0.45 0.0042 0.089 0.0512 0, .0037 0.0044 0, .0028 0.1681
Manx 5757 1 0.0052 0, .0105 0.232 0, .0023 0, ,0019 0, .0066 0, ,0085 0, .0088 0.0106 0.4071 0.0034 0.1137 0.0038 0, .0103 0.0018 0, .0053 0.1682
Manx 6294 0 0.0072 0, .0036 0.0713 0, .0036 0, ,0013 0, .002 0, ,0131 0, .0049 0.003 0.5938 0.0021 0.1068 0.0116 0, .0024 0.0033 0, .0041 0.1659
Manx 6296 1 0.0071 0, .0151 0.0902 0, .0028 0, ,0023 0, .0035 0, ,033 0, .0187 0.0037 0.4694 0.0052 0.1305 0.0307 0, .0072 0.002 0, .0038 0.1748
Manx 6299 3 0.0039 0, .0081 0.2136 0, .0118 0, ,0014 0, .0084 0, ,0056 0, .2642 0.0094 0.1142 0.0024 0.1602 0.009 0, .0031 0.0025 0, .0032 0.1791
Manx 7079 3 0.0021 0. .0051 0.0863 0. .0041 0. ,0019 0, .001 0, ,0069 0, .0087 0.003 0.6472 0.0061 0.0799 0.0094 0, .0039 0.0018 0, .0065 0.1261
Manx 7082 0 0.0039 0, .0041 0.2686 0, .0016 0, ,0015 0, .0016 0, ,0041 0, .0052 0.0039 0.36 0.002 0.159 0.0097 0, .0054 0.001 0, .0056 0.1629
Manx 7083 0 0.0027 0, .0074 0.0887 0, .0019 0, ,0022 0, .0032 0, ,0256 0, .0067 0.0022 0.5248 0.0069 0.1002 0.0267 0, .0037 0.0041 0, .0202 0.1728
Manx 7105 8 0.0142 0, .0023 0.0435 0, .0106 0, ,0591 0, .0126 0, ,6295 0, .0726 0.0024 0.0362 0.0127 0.0242 0.0097 0, .0108 0.0072 0, .0229 0.0295
Manx 7108 5 0.0045 0, .006 0.0212 0, .0033 0, ,0031 0, .012 0, ,2192 0, .5462 0.0015 0.0203 0.0069 0.0344 0.003 0, .0561 0.0047 0, .0101 0.0473
Manx 7112 17 0.0146 0. .0067 0.0712 0. .0059 0. ,001 0, .003 0, ,0072 0, .0888 0.0091 0.4508 0.001 0.1166 0.0185 0, .0154 0.0039 0, .0449 0.1414
Manx 7708 0 0.0169 0, .003 0.0062 0, .0106 0, ,002 0, .002 0, ,0078 0, .0485 0.0028 0.0244 0.0022 0.0055 0.821 0, .0264 0.0039 0, .0047 0.012
Manx 9084 2 0.0229 0, .007 0.0111 0, .0202 0, ,0074 0, .0144 0, ,0327 0, .0062 0.0106 0.2454 0.0048 0.0199 0.4794 0, .0184 0.0632 0, .0158 0.0207
Manx 9091 1 0.0048 0, .331 0.0181 0, .0023 0, ,0037 0, .014 0, , 1974 0, .045 0.0041 0.0283 0.0029 0.0613 0.2251 0, .0251 0.0031 0, .003 0.0309
Egyptian
Mau 1812 0 0.1072 0. .017 0.009 0. .0031 0. ,0189 0, .003 0, ,0834 0, .0363 0.0033 0.0102 0.0073 0.0141 0.625 0, .0273 0.0061 0, .0061 0.0226
Egyptian
Mau 2431 0 0.0165 0, .0103 0.0169 0, .0099 0, ,0021 0, .0191 0, ,0094 0, .0223 0.0038 0.0368 0.003 0.0568 0.7314 0, .005 0.0037 0, .0179 0.0351
Egyptian
Mau 2433 1 0.0038 0, .0048 0.0051 0, .0011 0, ,001 0, .002 0, ,0088 0, .0115 0.0017 0.01 0.0027 0.0144 0.8833 0, .0126 0.0011 0, .0127 0.0233
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Egyptian
Mau 3331 0 0.0073 0 0708 0.0036 0 007 0.0184 0 0054 0 0382 0 0123 0.0019 0.0068 0.0084 0.0048 0.746 0.0016 0.0451 0.0071 0.0154
Egyptian
Mau 3332 0 0.0057 0 0179 0.0071 0 005 0.0256 0 0055 0 0198 0 0138 0.0032 0.0285 0.0107 0.0159 0.7932 0.0084 0.0133 0.0113 0.015
Egyptian
Mau 5545 6 0.0065 0 0175 0.0144 0 0032 0.0027 0 0026 0 0054 0 0167 0.002 0.0058 0.0019 0.0172 0.8843 0.0048 0.0029 0.0073 0.0048
Egyptian
Mau 5553 11 0.0502 0 0171 0.0193 0 0057 0.0024 0 0046 0 006 0 0092 0.0019 0.0134 0.004 0.0208 0.7785 0.0162 0.002 0.0185 0.0302
Egyptian
Mau 5567 0 0.0032 0 0046 0.0261 0 0288 0.0336 0 0037 0 0841 0 0309 0.006 0.0142 0.0035 0.0215 0.6683 0.004 0.0136 0.0196 0.0344
Egyptian
Mau 5568 8 0.0236 0 0063 0.016 0 0054 0.002 0 0183 0 1136 0 0176 0.0032 0.063 0.0054 0.0422 0.6282 0.0059 0.0023 0.0133 0.0337
Egyptian
Mau 7475 0 0.0115 0 0672 0.0046 0 0062 0.0317 0 0238 0 0303 0 0217 0.0024 0.0079 0.0203 0.0287 0.7119 0.0052 0.0051 0.0116 0.0099
Egyptian
Mau 7476 0 0.0036 0 0064 0.0037 0 0039 0.0029 0 002 0 0066 0 004 0.0023 0.0053 0.0036 0.0034 0.8813 0.0029 0.0036 0.0615 0.0031
Egyptian
Mau 7479 0 0.003 0 0076 0.0043 0 0077 0.0056 0 0029 0 2979 0 0047 0.002 0.0047 0.006 0.0035 0.6308 0.0031 0.0033 0.0098 0.0031
Egyptian
Mau 7480 2 0.005 0 0095 0.002 0 002 0.021 0 0071 0 0036 0 0029 0.0018 0.0032 0.0319 0.0024 0.8849 0.0016 0.0028 0.0041 0.0142
Egyptian
Mau 11410 5 0.002 0 0123 0.0833 0 004 0.0073 0 001 0 0036 0 003 0.0217 0.0112 0.0019 0.0195 0.8121 0.004 0.0015 0.0041 0.0076
Turk.
Angora 607 1 0.0123 0 0055 0.0131 0 0043 0.0049 0 01 0 0625 0 0808 0.002 0.033 0.0049 0.0172 0.6397 0.0066 0.0076 0.0825 0.0132
Turk.
Angora 1832 5 0.0021 0 0333 0.0048 0 0023 0.001 0 002 0 0074 0 0044 0.001 0.0079 0.002 0.0025 0.9204 0.0031 0.001 0.0027 0.0021
Turk.
Angora 1845 6 0.0101 0 015 0.0083 0 001 0.0023 0 0024 0 0059 0 0128 0.0097 0.0224 0.0024 0.0194 0.7297 0.0208 0.0021 0.1201 0.0156
Turk.
Angora 2848 0 0.0269 0 0038 0.0064 0 0018 0.0047 0 008 0 0878 0 0112 0.0239 0.0072 0.0054 0.0089 0.7786 0.0076 0.0031 0.004 0.0106
Turk.
Angora 2862 4 0.0041 0 0061 0.0045 0 001 0.0027 0 0021 0 0031 0 0023 0.0019 0.0027 0.0016 0.0082 0.9461 0.0037 0.0047 0.001 0.0041
Turk.
Angora 5552 1 0.0074 0 0031 0.0087 0 003 0.0055 0 0043 0 0085 0 0383 0.0035 0.0172 0.0021 0.0073 0.7871 0.0077 0.03 0.0581 0.0082
Turk. 5563 0 0.0063 0 0055 0.0027 0 0029 0.0031 0 0023 0 0046 0 0064 0.0031 0.0041 0.0072 0.005 0.929 0.0051 0.002 0.0044 0.0063
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Angora
Turk.
Angora 5564 10 0.0049 0. .0019 0.0028 0. .0057 0.0014 0. .002 0. .0033 0, .0057 0, ,002 0, .0042 0, ,0029 0, .0035 0.9505 0, .0024 0, ,001 0, .0022 0.0036 Turk.
Angora 6350 5 0.0318 0, .0117 0.0086 0, .004 0.0103 0, .0799 0, ,087 0, .0112 0, ,0051 0, .0229 0, ,0123 0, .007 0.6462 0, .0047 0, ,0121 0, .0087 0.0364 Turk.
Angora 9541 8 0.0064 0, .0278 0.0066 0, .0024 0.0194 0, .0021 0, ,0854 0, .0181 0, ,0046 0, .0028 0, ,0049 0, .0071 0.7741 0, .0039 0, ,019 0, .0042 0.0111 Turk.
Angora 9542 1 0.003 0, .0074 0.0029 0, .002 0.0063 0, .023 0, ,0289 0, .0351 0, ,0028 0, .0224 0, ,0055 0, .0156 0.7847 0, .0042 0, ,0066 0, .0415 0.0081 Turk.
Angora 9584 1 0.0173 0. .0346 0.0453 0. .0024 0.0032 0. .0038 0. ,0736 0, .0299 0, ,0044 0, .0689 0, ,0024 0, .0811 0.4471 0, .0129 0, ,0032 0, .1383 0.0316 Turk.
Angora 9586 2 0.0035 0, .0074 0.0163 0, .0052 0.0021 0, .0014 0, ,0244 0, .0043 0, ,0024 0, .0055 0, ,0038 0, .0671 0.837 0, .0047 0, ,003 0, .0062 0.0057 Turk.
Angora 9608 2 0.0032 0, .0648 0.0072 0, .0046 0.0039 0, .005 0, ,006 0, .0127 0, ,0016 0, .0089 0, ,0036 0, .0065 0.8319 0, .0072 0, ,0197 0, .0057 0.0075 Turk.
Angora 9609 10 0.0139 0, .0308 0.0048 0, .0022 0.0031 0, .021 0, ,0041 0, .0252 0, ,005 0, .0154 0, ,0056 0, .0068 0.8347 0, .0043 0, ,0052 0, .0115 0.0063 Turk.
Angora 9610 7 0.0034 0, .0128 0.0034 0, .001 0.0187 0, .0078 0, ,0065 0, .0096 0, ,0123 0, .006 0, ,0085 0, .0052 0.8537 0, .0102 0, ,011 0, .0033 0.0266 Turk.
Angora 9611 2 0.02 0. .0027 0.0063 0. .0136 0.0012 0. .008 0. ,0077 0, .0234 0, ,0019 0, .1127 0, ,0028 0, .0121 0.7586 0, .0039 0, ,0089 0, .011 0.0053 Turk.
Angora 9612 9 0.0049 0, .002 0.0055 0, .0422 0.0029 0, .0046 0, ,0404 0, .0304 0, ,0025 0, .7876 0, ,0061 0, .0044 0.0042 0, .0079 0, ,0031 0, .0475 0.0037 Turk.
Angora 9613 1 0.0022 0, .0145 0.0199 0, .0112 0.0122 0, .0057 0, ,0052 0, .0037 0, ,0036 0, .8433 0, ,0266 0, .0092 0.0114 0, .0062 0, ,0099 0, .0051 0.0101 Turk.
Angora 9614 0 0.0294 0, .0139 0.0048 0, .0046 0.0287 0, .0208 0, ,0258 0, .0084 0, ,0019 0, .766 0, ,0355 0, .0125 0.0057 0, .0178 0, ,0026 0, .0111 0.0105 Turk.
Angora 9615 2 0.0076 0, .0043 0.0036 0, .0051 0.0111 0, .0038 0, ,0035 0, .0033 0, ,0018 0, .8982 0, ,018 0, .0048 0.0037 0, .0033 0, ,0159 0, .0032 0.0088 Turkish
Van 1789 6 0.0059 0. .0062 0.0181 0. .0032 0.0022 0. .0025 0. ,0337 0, .0081 0, ,009 0, .8286 0, ,0034 0, .0064 0.018 0, .0032 0, .0025 0, .0406 0.0084 Turkish
Van 3013 1 0.006 0, .0121 0.0043 0, .0308 0.0044 0, .0035 0, ,0111 0, .005 0, ,0012 0, .852 0, ,0031 0, .006 0.0058 0, .0112 0, .0059 0, .0314 0.0061 Turkish
Van 3056 2 0.0049 0, .017 0.0059 0, .0028 0.0037 0, .0061 0, ,0042 0, .0042 0, ,0028 0, .8905 0, ,0165 0, .0096 0.0066 0, .0077 0, .0038 0, .0052 0.0085
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Turkish
Van 4090 7 0.0259 0.0036 0.0068 0.0089 0.0169 0.0053 0.0051 0.0084 0.0019 0.787 0.0808 0.0094 0.0064 0.0034 0.0114 0.0044 0.0144
Turkish
Van 7662 2 0.0044 0.0022 0.0397 0.0344 0.0037 0.0079 0.0075 0.0077 0.001 0.8116 0.0339 0.0197 0.0045 0.0039 0.0076 0.0066 0.0037
Turkish
Van 7663 3 0.0046 0.0051 0.0026 0.0021 0.0044 0.0074 0.0054 0.0055 0.0015 0.9341 0.003 0.0058 0.0036 0.0033 0.0024 0.0041 0.0051
Turkish
Van 7666 1 0.0023 0.005 0.0307 0.0021 0.0172 0.0031 0.014 0.01 0.0029 0.6741 0.17 0.0051 0.0039 0.0209 0.005 0.0285 0.0051
Turkish
Van 7667 17 0.0174 0.0049 0.0862 0.1776 0.0035 0.005 0.0044 0.0469 0.0017 0.6215 0.0019 0.0079 0.004 0.0037 0.0025 0.007 0.0038
Turkish
Van 9322 4 0.0055 0.0101 0.0184 0.002 0.201 0.0143 0.0041 0.004 0.0072 0.6373 0.0036 0.009 0.0439 0.0055 0.0088 0.005 0.0202
Turkish
Van 9535 6 0.002 0.0217 0.0059 0.0026 0.002 0.0017 0.0037 0.0047 0.0027 0.9194 0.0029 0.0095 0.0037 0.0038 0.002 0.0082 0.0036
Turkish
Van 9538 4 0.0105 0.0042 0.0586 0.002 0.0148 0.0033 0.0152 0.0041 0.0175 0.7686 0.0022 0.0064 0.0047 0.0035 0.0493 0.0161 0.019
Turkish
Van 9539 2 0.0061 0.002 0.0134 0.0032 0.0018 0.004 0.0092 0.0052 0.0018 0.8995 0.0021 0.0096 0.0112 0.0037 0.0029 0.0167 0.0076
Turkish
Van 9543 6 0.0047 0.0047 0.0114 0.0095 0.0154 0.0137 0.0179 0.0112 0.0022 0.8275 0.0191 0.0193 0.0097 0.004 0.0035 0.0191 0.0072
Turkish
Van 9563 12 0.0055 0.0043 0.0043 0.0745 0.1379 0.0035 0.0125 0.4148 0.0053 0.0096 0.0038 0.0043 0.0039 0.2531 0.049 0.0062 0.0075 Turkish
Van 9564 0 0.0069 0.0049 0.0764 0.01 0.0354 0.0123 0.0251 0.199 0.0048 0.3185 0.0108 0.0908 0.0052 0.0221 0.0028 0.0037 0.1713
Turkish
Van 9573 2 0.046 0.0028 0.087 0.0052 0.0023 0.0031 0.0139 0.099 0.0039 0.2677 0.0021 0.1381 0.0025 0.0822 0.0019 0.0627 0.1797
Turkish
Van 9574 6 0.0057 0.0228 0.0766 0.0064 0.0025 0.028 0.0801 0.2059 0.0027 0.0873 0.0039 0.2216 0.0119 0.0282 0.0042 0.0332 0.179
Turkish
Van 9575 10 0.0254 0.0032 0.007 0.0125 0.0047 0.0118 0.7715 0.02 0.0047 0.0294 0.0139 0.0285 0.0038 0.0253 0.0047 0.004 0.0295
Turkish
Van 9576 9 0.0093 0.0097 0.0116 0.0106 0.0037 0.0389 0.1459 0.4242 0.0014 0.0252 0.0067 0.0886 0.0074 0.0969 0.0032 0.0154 0.1013
Turkish
Van 9581 12 0.0399 0.0051 0.0998 0.0062 0.0073 0.0495 0.0086 0.2752 0.0063 0.0491 0.0023 0.0861 0.0738 0.0262 0.0172 0.1126 0.1347
Bengal 2518 10 0.0252 0.0014 0.0094 0.0101 0.0029 0.0186 0.033 0.4085 0.0023 0.2062 0.002 0.0851 0.0119 0.0084 0.0054 0.0157 0.1539
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bengal 3455 3 0.0111 0, .0068 0.0243 0.002 0.0082 0, .0024 0, ,3067 0, .1636 0, , 1962 0.0546 0.004 0.0082 0.0207 0.1638 0.0072 0, .0052 0.015
Bengal 3478 18 0.0132 0, .0051 0.0248 0.0701 0.0048 0, .026 0, ,0113 0, .6078 0, ,0202 0.0643 0.0057 0.0446 0.0064 0.0052 0.0059 0, .0153 0.0694
Bengal 3522 12 0.0073 0. .0028 0.1736 0.0035 0.0017 0. .0092 0. ,0042 0, .012 0, ,0025 0.4492 0.002 0.1066 0.0034 0.0287 0.002 0, .0046 0.1867
Bengal 3541 1 0.0224 0, .0054 0.0121 0.0429 0.0397 0, .0037 0, ,2309 0, .263 0, ,0212 0.0592 0.0197 0.0701 0.0095 0.0098 0.0459 0, .0221 0.1224
Bengal 3550 0 0.0182 0, .0194 0.0483 0.0036 0.0095 0, .0048 0, ,0395 0, .1681 0, ,0178 0.0715 0.0513 0.2959 0.01 0.0168 0.0046 0, .0594 0.1613
Bengal 6678 2 0.0182 0, .0042 0.1058 0.0067 0.001 0, .0029 0, ,022 0, .2968 0, ,0027 0.1273 0.0011 0.1697 0.0131 0.0093 0.0024 0, .0113 0.2055
Bengal 6899 2 0.0139 0, .0085 0.0159 0.0037 0.0039 0, .0031 0, ,5038 0, .1083 0, , 1169 0.0155 0.0033 0.0669 0.0119 0.0273 0.0017 0, .0222 0.0733
Bengal 6902 12 0.6799 0, .0038 0.0087 0.0053 0.0054 0, .0143 0, ,0251 0, .0144 0, ,0033 0.0067 0.0416 0.0672 0.0059 0.0104 0.0026 0, .0389 0.0665
Bengal 6907 6 0.6325 0, .0039 0.0069 0.0069 0.0055 0, .0014 0, ,0071 0, .0155 0, ,0481 0.0168 0.0042 0.1132 0.0162 0.0068 0.011 0, .0088 0.0953
Bengal 8399 6 0.6618 0, .0053 0.0467 0.002 0.0022 0, .0061 0, ,0064 0, .023 0, ,0029 0.0086 0.0031 0.0979 0.0116 0.0296 0.0012 0, .0074 0.0842
Bengal 8400 6 0.7636 0. .002 0.0027 0.0015 0.001 0. .0019 0. ,0046 0, .0028 0, ,0031 0.0034 0.003 0.0959 0.0073 0.0055 0.0012 0, .0035 0.097
Bengal 8766 14 0.7295 0, .0012 0.004 0.0135 0.0061 0, .0028 0, ,0079 0, .0058 0, ,001 0.0056 0.0125 0.0926 0.0032 0.0126 0.0067 0, .0025 0.0925
Bengal 9053 15 0.7742 0, .002 0.0032 0.0019 0.0015 0, .0012 0, ,0022 0, .0036 0, ,001 0.0026 0.001 0.0982 0.0029 0.0034 0.001 0, .002 0.0981
Bengal 9800 6 0.6652 0, .0093 0.0164 0.064 0.0024 0, .0052 0, ,0044 0, .0064 0, ,0118 0.0054 0.0058 0.099 0.006 0.0042 0.003 0, .0093 0.0822
Bengal 10344 12 0.7778 0, .0024 0.0033 0.001 0.001 0, .0034 0, ,006 0, .0035 0, ,004 0.0051 0.0022 0.087 0.0079 0.0013 0.0012 0, .0078 0.0851
Bengal 10946 12 0.6542 0. .0026 0.0033 0.0117 0.0036 0. .0076 0. ,0052 0, .0471 0, ,0562 0.008 0.002 0.0893 0.0019 0.0063 0.002 0, .0053 0.0937
Bengal 11194 1 0.776 0, .002 0.002 0.002 0.0018 0, .0022 0, ,002 0, .0025 0, ,0015 0.0018 0.0022 0.0976 0.0022 0.003 0.0012 0, .002 0.098
Sokoke 1890 2 0.6563 0 .004 0.0092 0.006 0.001 0, .0013 0, ,0073 0, .0195 0, ,0059 0.0141 0.0022 0.0971 0.0255 0.0373 0.0019 0, .0087 0.1028
Sokoke 1898 4 0.8122 0 .0028 0.0028 0.0024 0.0022 0, .0032 0, ,0042 0, .0022 0, ,0037 0.004 0.0012 0.074 0.0019 0.0032 0.004 0, .0043 0.0717
Sokoke 2054 2 0.7688 0 .002 0.0021 0.0025 0.0025 0, .002 0, ,002 0, .0033 0, ,0041 0.0023 0.0017 0.0979 0.0029 0.0023 0.0021 0, .003 0.0985
Sokoke 2061 2 0.7072 0 .0022 0.0148 0.0454 0.0013 0. .005 0. ,0025 0, .0071 0, ,0037 0.0039 0.002 0.0923 0.005 0.0116 0.0025 0, .0026 0.0909
Sokoke 2063 18 0.0038 0 .1292 0.0061 0.0023 0.0025 0, .7543 0, ,0054 0, .0099 0, ,0048 0.0169 0.0036 0.0122 0.0049 0.0225 0.003 0, .0115 0.0071
Sokoke 2067 16 0.0024 0 .003 0.0011 0.001 0.0026 0, .9686 0, ,002 0, .002 0, ,0018 0.0014 0.0021 0.0019 0.0023 0.0026 0.002 0, .001 0.0022
Sokoke 6615 6 0.001 0 .001 0.001 0.0011 0.002 0, .9815 0, ,001 0, .001 0, ,001 0.001 0.002 0.001 0.001 0.0012 0.001 0, .0012 0.001
Ocicat 2933 13 0.0103 0, .0046 0.0028 0.0058 0.0073 0, .9242 0, ,003 0, .003 0, ,0011 0.0025 0.0101 0.0036 0.0042 0.0048 0.0042 0, .0036 0.0049
Ocicat 2951 3 0.0018 0. .0067 0.002 0.0023 0.0244 0. .9116 0. ,002 0, .0053 0, ,0021 0.0025 0.0043 0.0019 0.002 0.002 0.0211 0, .0037 0.0043
Ocicat 2954 6 0.0022 0, .0022 0.0014 0.0012 0.005 0, .968 0, ,002 0, .0021 0, ,001 0.0021 0.002 0.0012 0.001 0.0018 0.0025 0, .0019 0.0024
Ocicat 3514 10 0.0078 0, .008 0.0027 0.0059 0.0936 0, .6685 0, ,0088 0, .0083 0, ,002 0.0063 0.1174 0.0051 0.0053 0.003 0.0044 0, .0161 0.0368
Ocicat 5744 0 0.0041 0, .0061 0.0121 0.0033 0.0161 0, .0044 0, ,0141 0, .5178 0, ,0057 0.0152 0.0075 0.0101 0.0153 0.002 0.2625 0, .0963 0.0074
Ocicat 9966 12 0.0174 0, .0085 0.003 0.0021 0.0021 0, .0084 0, ,011 0, .8611 0, ,0072 0.0044 0.0027 0.0052 0.017 0.0201 0.001 0, .024 0.0048
Ocicat 9967 14 0.002 0. .0027 0.0023 0.0067 0.0169 0. .0037 0. ,0099 0, .8953 0, ,0022 0.0071 0.0153 0.0044 0.0022 0.0096 0.004 0, .011 0.0047
Ocicat 10400 17 0.1411 0, .0104 0.0184 0.0047 0.031 0, .0028 0, ,0073 0, .3582 0, ,0197 0.0468 0.0862 0.1401 0.0405 0.0201 0.0032 0, .0154 0.0542
Ocicat 10652 20 0.011 0, .003 0.0038 0.0113 0.0035 0, .0062 0, ,006 0, .8187 0, ,0022 0.0073 0.0036 0.0051 0.0056 0.0716 0.0272 0, .0065 0.0074
Ocicat 10654 11 0.0038 0. .0012 0.0039 0.0018 0.001 0. .0043 0. ,003 0, .9572 0, ,0062 0.0031 0.001 0.0019 0.0013 0.0041 0.001 0, .0032 0.002
Russian 1834 14 0.005 0, .0036 0.0099 0.0051 0.002 0, .0077 0, , 1095 0, .735 0, ,0043 0.0376 0.0025 0.0115 0.0104 0.0185 0.0133 0, .0052 0.019
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Blue
Russian
Blue 1835 13 0.0052 0.0272 0.1582 0.0055 0.0064 0.001 0.0117 0.6653 0.0218 0.0157 0.0026 0.0107 0.0128 0.0183 0.02 0.0067 0.0109
Russian
Blue 2505 6 0.0047 0.0123 0.0034 0.0309 0.0564 0.0114 0.0051 0.7558 0.0163 0.0085 0.0024 0.0058 0.003 0.0351 0.0056 0.0115 0.0318
Russian
Blue 4068 8 0.0097 0.012 0.028 0.0026 0.0051 0.0072 0.0724 0.1258 0.0045 0.0752 0.0203 0.0113 0.0098 0.1044 0.0172 0.4776 0.017
Russian
Blue 4072 2 0.0012 0.002 0.0023 0.0028 0.002 0.0043 0.0051 0.0977 0.002 0.0064 0.0032 0.0057 0.002 0.8561 0.0012 0.0029 0.0031
Russian
Blue 4074 14 0.0703 0.0027 0.4326 0.0085 0.0043 0.04 0.1037 0.0966 0.0033 0.0339 0.0881 0.0213 0.0079 0.0074 0.0113 0.0599 0.0081
Russian
Blue 4076 9 0.03 0.01 0.039 0.0039 0.002 0.0059 0.0035 0.4242 0.0048 0.0651 0.0013 0.2547 0.0022 0.014 0.0029 0.0839 0.0526
Russian
Blue 4077 2 0.0558 0.0157 0.0121 0.0078 0.0048 0.0026 0.045 0.7749 0.0073 0.0074 0.0071 0.0075 0.0136 0.0156 0.0021 0.0104 0.0103
Russian
Blue 4078 21 0.0112 0.0114 0.0105 0.0169 0.0311 0.0213 0.0115 0.6287 0.0112 0.0548 0.0114 0.0171 0.0288 0.0841 0.0187 0.0102 0.0211
Russian
Blue 4302 14 0.0029 0.0029 0.0025 0.0022 0.0042 0.0047 0.003 0.9139 0.0015 0.0038 0.0157 0.0032 0.0042 0.0205 0.0063 0.0055 0.003
Russian
Blue 4867 6 0.0039 0.0048 0.0045 0.0151 0.0014 0.0027 0.0088 0.9054 0.0025 0.0071 0.0026 0.0063 0.0167 0.0059 0.0025 0.0044 0.0054
Russian
Blue 4869 9 0.0314 0.0097 0.0185 0.0058 0.0122 0.0034 0.0122 0.7102 0.0122 0.0151 0.0104 0.005 0.0068 0.1176 0.0032 0.0169 0.0095
Russian
Blue 5216 0 0.0045 0.0818 0.0424 0.0021 0.0026 0.0017 0.005 0.5951 0.0028 0.0128 0.0011 0.0194 0.1819 0.0145 0.0047 0.0187 0.0089
Russian
Blue 5630 2 0.0036 0.0054 0.0039 0.0275 0.004 0.0053 0.0136 0.8921 0.0023 0.0052 0.0045 0.0029 0.0066 0.0034 0.0092 0.0064 0.0041
Russian
Blue 5631 6 0.0075 0.0156 0.0049 0.003 0.003 0.0196 0.0095 0.7978 0.0109 0.0076 0.0034 0.012 0.0724 0.0114 0.004 0.004 0.0134
Russian
Blue 5704 12 0.0048 0.005 0.005 0.0354 0.004 0.0435 0.031 0.0949 0.0018 0.0071 0.0023 0.0043 0.003 0.7369 0.0139 0.0022 0.0049
Russian
Blue 5709 5 0.0048 0. ,0023 0.0025 0, .009 0, ,0211 0, .001 0, ,0056 0, .0858 0, ,0058 0, .002 0, ,0066 0, .0025 0, ,0016 0, .7793 0, ,0461 0, .0148 0.0092
Aust. Mist 4716 10 0.0013 0. .004 0.0035 0. .002 0. ,001 0, .002 0, ,0069 0, .0865 0, ,002 0, .0043 0, ,0018 0, .0057 0, ,0865 0, .7681 0, ,003 0, .0021 0.0194 Aust. Mist 4718 20 0.0085 0, .0031 0.0161 0, .0039 0, ,0021 0, .0031 0, ,0043 0, .0923 0, ,0018 0, .0182 0, ,0012 0, .0104 0, ,0043 0, .8184 0, ,002 0, .0037 0.0066
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Aust. Mist 4720 1 0.0189 0 .0035 0.0129 0, .0155 0, ,0078 0, .0051 0, ,029 0, .1144 0, ,0077 0.0256 0.0113 0.0064 0.006 0, .7032 0.0058 0, .0141 0.0129
Aust. Mist 4722 2 0.0153 0 .0041 0.0118 0, .0031 0, ,003 0, .0035 0, ,0047 0, .3428 0, ,0097 0.0089 0.0021 0.0078 0.005 0, .4904 0.0061 0, .0756 0.0062
Aust. Mist 4723 1 0.0047 0 .0044 0.0082 0. .0028 0. ,0158 0, .0073 0, ,0142 0, .0881 0, ,0016 0.0291 0.0054 0.007 0.0043 0, .753 0.0404 0, .0031 0.0106
Aust. Mist 4724 6 0.0023 0 .0117 0.0025 0, .0028 0, ,003 0, .0053 0, ,0058 0, .0995 0, ,0013 0.0043 0.0031 0.0076 0.0036 0, .827 0.003 0, .0142 0.003
Aust. Mist 4725 8 0.0079 0 .0026 0.1771 0, .0096 0, ,0046 0, .002 0, ,002 0, .0801 0, ,0035 0.0058 0.0162 0.0072 0.0021 0, .6691 0.0012 0, .0031 0.0059
Aust. Mist 4727 2 0.012 0 .0021 0.0015 0, .0041 0, ,0024 0, .0019 0, ,0044 0, .0973 0, ,002 0.0028 0.0072 0.0023 0.0019 0, .8403 0.0116 0, .0038 0.0025
Aust. Mist 4731 3 0.0019 0 .0038 0.0039 0, .0023 0, ,0046 0, .0015 0, ,0054 0, .1014 0, ,0027 0.0037 0.0019 0.0034 0.0021 0, .8452 0.0059 0, .0049 0.0054
Aust. Mist 4736 16 0.0058 0 .1341 0.0457 0, .001 0, ,001 0, .002 0, ,005 0, .1049 0, ,0036 0.0319 0.0015 0.0547 0.0105 0, .5603 0.001 0, .0164 0.0205
Aust. Mist 4739 2 0.0326 0 .0087 0.0589 0, .03 0, ,0061 0, .0041 0, ,0336 0, .4825 0, ,0077 0.0347 0.008 0.013 0.0267 0, .1074 0.0047 0, .1187 0.0226
Aust. Mist 6184 0 0.0074 0 .0031 0.0042 0, .0031 0, ,0032 0, .0019 0, ,0127 0, .1207 0, ,0025 0.0176 0.0064 0.0162 0.0066 0, .7254 0.0017 0, .0606 0.0067
Aust. Mist 6187 1 0.0079 0 .002 0.0185 0. .002 0. ,001 0, .002 0, ,0043 0, .103 0, ,0077 0.0059 0.0028 0.0094 0.0045 0, .813 0.001 0, .008 0.007
Aust. Mist 6188 5 0.0024 0 .0022 0.0016 0, .0018 0, ,0019 0, .0025 0, ,0021 0, .1 0, ,001 0.002 0.002 0.0021 0.002 0, .8705 0.002 0, .0021 0.0018
Aust. Mist 6189 3 0.0052 0 .002 0.0222 0, .0031 0, ,0022 0, .0038 0, ,0215 0, .1087 0, ,0056 0.0094 0.002 0.0048 0.0036 0, .7811 0.003 0, .0173 0.0045
Burmese 21 5 0.1445 0, .02 0.005 0, .0155 0, ,018 0, .0308 0, , 121 0, .1126 0, ,0265 0.3899 0.0135 0.0204 0.0182 0, .0136 0.0149 0, .0162 0.0194
Burmese 22 6 0.0123 0, .0035 0.0092 0, .0028 0, ,0039 0, .0031 0, ,0539 0, .2275 0, ,0053 0.4045 0.018 0.0349 0.0026 0, .0225 0.007 0, .1359 0.053
Burmese 23 7 0.0179 0. .1323 0.0207 0. .036 0. ,011 0, .0099 0, ,0057 0, .1692 0, ,0074 0.2078 0.0129 0.1253 0.0081 0, .0841 0.0125 0, .0334 0.1056
Burmese 24 2 0.0012 0, .9257 0.001 0, .0035 0, ,0322 0, .0079 0, ,002 0, .001 0, ,001 0.001 0.0048 0.0011 0.0017 0, .001 0.0073 0, .0019 0.0056
Burmese 25 0 0.003 0, .948 0.0022 0, .002 0, ,005 0, .0024 0, ,0032 0, .002 0, ,001 0.0041 0.002 0.0041 0.003 0, .002 0.0069 0, .006 0.0031
Burmese 26 3 0.0039 0, .9451 0.002 0, .0012 0, ,0019 0, .0011 0, ,0075 0, .0014 0, ,0024 0.0021 0.002 0.0023 0.002 0, .0016 0.0028 0, .019 0.0017
Burmese 27 2 0.0024 0, .9565 0.002 0, .0013 0, ,0029 0, .0042 0, ,0029 0, .0015 0, ,001 0.0026 0.0059 0.0027 0.003 0, .0032 0.0029 0, .0028 0.0022
Burmese 28 1 0.0041 0. .8728 0.0133 0. .002 0. ,0039 0, .003 0, ,0032 0, .0021 0, ,0017 0.0053 0.004 0.0388 0.0239 0, .0028 0.0074 0, .0059 0.0058
Burmese 29 3 0.0021 0, .9592 0.0028 0, .002 0, ,0024 0, .0012 0, ,002 0, .0029 0, ,0025 0.0028 0.0011 0.0025 0.0038 0, .0035 0.003 0, .0036 0.0026
Burmese 4401 12 0.0018 0, .9677 0.0019 0, .001 0, ,0025 0, .0039 0, ,0029 0, .0013 0, ,001 0.0015 0.0044 0.0016 0.0023 0, .0011 0.0016 0, .002 0.0015
Burmese 4691 12 0.0083 0, .8251 0.0059 0, .0067 0, ,0059 0, .0182 0, ,004 0, .0139 0, ,002 0.0186 0.0062 0.0282 0.0163 0, .0106 0.002 0, .0063 0.0219
Burmese 4781 1 0.0035 0, .8873 0.0034 0, .0025 0, ,0149 0, .0018 0, ,0082 0, .0071 0, ,0071 0.0093 0.0034 0.0145 0.0061 0, .0122 0.0028 0, .0023 0.0135
Burmese 4782 1 0.0509 0. .7588 0.0131 0. .0314 0. ,0036 0, .0072 0, ,0059 0, .0083 0, ,0033 0.0314 0.0015 0.0124 0.0223 0, .0081 0.0074 0, .0141 0.0203
Burmese 5425 1 0.0193 0, .7378 0.0057 0, .0555 0, ,0079 0, .0133 0, ,0036 0, .0186 0, ,0021 0.0288 0.0276 0.007 0.0109 0, .0242 0.0017 0, .0046 0.0315
Burmese 5800 11 0.0028 0, .9277 0.0024 0, .0025 0, ,0031 0, .0017 0, ,0055 0, .0055 0, ,0021 0.0024 0.0093 0.0018 0.004 0, .0042 0.0174 0, .003 0.0046
Burmese 6182 2 0.0018 0, .9522 0.0026 0, .002 0, ,0028 0, .002 0, ,0035 0, .0022 0, ,002 0.0038 0.005 0.003 0.0044 0, .0043 0.0026 0, .0031 0.0027
Burmese 6471 2 0.0019 0, .9607 0.002 0, .0016 0, ,002 0, .003 0, ,0022 0, .0036 0, ,0028 0.0026 0.001 0.0024 0.0036 0, .0022 0.0013 0, .0048 0.0023
Burmese 6962 2 0.0045 0. .9231 0.002 0. .002 0. ,0057 0, .0071 0, ,0022 0, .0033 0, ,003 0.0041 0.0182 0.0039 0.0025 0, .0084 0.0027 0, .0031 0.0042
Burmese 6964 13 0.0119 0, .0088 0.1073 0, .0061 0, ,0071 0, .0168 0, ,0166 0, .1634 0, ,004 0.1736 0.0031 0.241 0.0035 0, .0411 0.0095 0, .0263 0.16
Birman 1760 14 0.0349 0, .0083 0.0799 0, .0857 0, ,002 0, .007 0, ,0052 0, .0726 0, ,012 0.0503 0.002 0.438 0.0198 0, .0105 0.002 0, .0172 0.1526
Birman 2917 8 0.0197 0. .0069 0.3869 0. .0079 0. ,0034 0, .0037 0, ,0162 0, .0165 0, ,0039 0.0934 0.0056 0.2611 0.0075 0, .0111 0.0107 0, .0135 0.1321
Birman 3910 2 0.0404 0, .0101 0.147 0, .0234 0, ,001 0, .002 0, ,013 0, .0452 0, ,0134 0.0424 0.0018 0.0313 0.5564 0, .0088 0.0036 0, .0025 0.0578
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Birman 5029 1 0.0236 0, .0052 0.159 0.0025 0.0054 0, .0032 0, .03 0, .0177 0.0279 0.1649 0.0023 0.1807 0.1692 0.0112 0.0053 0, .0196 0.1724
Birman 5033 1 0.0039 0, .0091 0.0568 0.0144 0.0015 0, .0257 0, , 1181 0, .0605 0.0024 0.0854 0.0023 0.1599 0.0906 0.0072 0.033 0, .1732 0.1559
Birman 5034 0 0.0032 0. .0051 0.1896 0.0028 0.0245 0. .0045 0. .006 0, .1924 0.0124 0.0835 0.0155 0.2938 0.0187 0.0057 0.0058 0, .0037 0.1328
Birman 5038 1 0.0039 0, .0045 0.161 0.0744 0.0017 0, .0028 0, ,0235 0, .0091 0.0041 0.1452 0.0032 0.3542 0.0358 0.0071 0.008 0, .0066 0.1549
Birman 5151 1 0.0156 0, .0036 0.0887 0.0097 0.0019 0, .0034 0, ,0045 0, .215 0.0108 0.0848 0.002 0.3419 0.0219 0.0066 0.0034 0, .0096 0.1766
Birman 5576 0 0.004 0, .0123 0.1089 0.0063 0.001 0, .0014 0, ,0049 0, .0209 0.0027 0.4963 0.0026 0.0974 0.0227 0.0468 0.0017 0, .0039 0.1662
Birman 5578 0 0.0087 0, .0058 0.1156 0.0134 0.0036 0, .0034 0, ,0106 0, .0085 0.0025 0.4583 0.0049 0.0961 0.0632 0.0129 0.0107 0, .0045 0.1772
Birman 6448 2 0.0033 0, .0086 0.0945 0.0034 0.0014 0, .0031 0, ,0149 0, .2019 0.0057 0.0963 0.003 0.3349 0.0413 0.0036 0.0013 0, .0033 0.1795
Birman 6450 6 0.0115 0, .003 0.1261 0.0034 0.002 0, .0014 0, ,0092 0, .0937 0.0045 0.1289 0.002 0.3749 0.0069 0.0205 0.0023 0, .0194 0.1902
Birman 6526 5 0.0045 0, .0078 0.0858 0.0017 0.0014 0, .0021 0, ,0056 0, .0891 0.0034 0.1287 0.0027 0.4452 0.0161 0.0036 0.001 0, .0169 0.1843
Birman 6527 5 0.0395 0. .0055 0.019 0.0078 0.0045 0. .0168 0. ,052 0, .0581 0.0155 0.0424 0.0042 0.1022 0.4828 0.0618 0.0038 0, .0152 0.069
Birman 6528 0 0.0127 0, .053 0.0894 0.0117 0.001 0, .001 0, ,0062 0, .1642 0.0012 0.1261 0.0036 0.2747 0.0704 0.0051 0.0018 0, .0081 0.1698
Birman 6529 2 0.0093 0, .0208 0.0605 0.0035 0.0032 0, .0139 0, ,2812 0, .0861 0.0068 0.0755 0.0061 0.2131 0.0426 0.0195 0.0052 0, .0154 0.1372
Birman 6604 2 0.0078 0, .0031 0.0086 0.0082 0.0033 0, .0161 0, ,8459 0, .0342 0.0075 0.0195 0.0036 0.0098 0.0052 0.0062 0.0071 0, .008 0.0059
Birman 6607 0 0.002 0, .0043 0.0027 0.0029 0.0081 0, .0038 0, ,9448 0, .0029 0.003 0.0036 0.0021 0.0016 0.002 0.0032 0.0054 0, .0038 0.0038
Birman 6608 0 0.0066 0. .002 0.0107 0.004 0.0035 0. .0041 0. ,8995 0, .0021 0.0021 0.0052 0.0157 0.007 0.0196 0.0029 0.0029 0, .0059 0.0062
Birman 6609 1 0.0044 0, .0062 0.0031 0.002 0.002 0, .0021 0, ,8791 0, .0237 0.002 0.0088 0.0015 0.003 0.008 0.0438 0.002 0, .0056 0.0027
Havana
Brn. 787 2 0.0022 0, .0056 0.0019 0.0025 0.0038 0, .0049 0, ,9431 0, .0021 0.001 0.0028 0.0132 0.0022 0.0029 0.0039 0.0027 0, .0027 0.0025
Havana
Brn. 2415 0 0.0061 0. .0968 0.007 0.0097 0.006 0. .0081 0. 7292 0, .0063 0.0145 0.0058 0.0198 0.0092 0.022 0.0061 0.0065 0, .0316 0.0153
Havana
Brn. 2500 0 0.0049 0, .0062 0.0061 0.0026 0.0265 0, .0026 0, ,8498 0, .0043 0.0059 0.0039 0.0062 0.0076 0.0048 0.0141 0.0314 0, .0122 0.011
Havana
Brn. 2501 0 0.0032 0, .0031 0.006 0.002 0.002 0, .002 0, 9278 0, .0025 0.001 0.005 0.0027 0.0066 0.0033 0.0164 0.005 0, .0091 0.0023
Havana
Brn. 2502 3 0.006 0, .0075 0.0081 0.002 0.147 0, .0077 0, ,7075 0, .0047 0.0014 0.0136 0.023 0.0151 0.0116 0.0067 0.0163 0, .0037 0.0181
Havana
Brn. 3312 1 0.0034 0, .0051 0.0036 0.0023 0.0014 0, .002 0, ,9295 0, .0046 0.001 0.0143 0.0063 0.0031 0.0082 0.0045 0.002 0, .0052 0.0034
Havana
Brn. 3404 1 0.0199 0. .0134 0.0033 0.0036 0.0024 0. .0108 0. ,8823 0, .0065 0.0031 0.0038 0.002 0.0116 0.0103 0.0034 0.0037 0, .0122 0.0077
Havana
Brn. 3513 0 0.0027 0, .0019 0.0037 0.0028 0.0168 0, .0049 0, ,8938 0, .0032 0.0064 0.0062 0.0192 0.0044 0.0051 0.003 0.0102 0, .0035 0.0123
Havana
Brn. 5707 0 0.0034 0, .002 0.004 0.0013 0.0025 0, .0026 0, ,9396 0, .0053 0.002 0.0052 0.003 0.0043 0.0069 0.005 0.0027 0, .0078 0.0024
J able 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Havana
Brn. 5708 2 0.0044 0, .0042 0.0032 0, .003 0.003 0, .002 0, ,9191 0, .0051 0, ,0021 0, .0032 0, ,0066 0, .0039 0.0051 0, .0054 0, ,0028 0, .0231 0.0038
Brn. 6972 0 0.0136 0, .0053 0.0025 0, .002 0.0041 0, .0082 0, ,8921 0, .0073 0, ,0223 0, .0039 0, ,0028 0, .0034 0.0021 0, .0078 0, ,0025 0, .0127 0.0074 navana
Brn. 6973 0 0.0267 0, .0151 0.1473 0, .0027 0.001 0, .002 0, ,034 0, .0032 0, ,0082 0, .4883 0, ,002 0, .0601 0.1698 0, .0119 0, ,0053 0, .0097 0.0126
Havana
Brn. 10350 4 0.0066 0, .0033 0.1676 0, .0017 0.001 0, .0047 0, ,0068 0, .0096 0, ,0527 0, .0097 0, ,0013 0, .0571 0.6417 0, .0088 0, ,002 0, .0095 0.016 navana
Brn. 5554 0 0.0042 0, .0078 0.1527 0, .0044 0.001 0, .0018 0, ,0071 0, .0053 0, ,0063 0, .044 0, ,002 0, .0116 0.7164 0, .0213 0, ,0016 0, .0087 0.0038
Korat 4708 2 0.0046 0. .0024 0.0972 0. .0019 0.001 0. .002 0. ,0165 0, .0152 0, ,0023 0, .0781 0, ,0011 0, .2501 0.3313 0, .0255 0, ,0012 0, .0103 0.1593
Korat 4711 1 0.0044 0, .0075 0.0304 0, .001 0.002 0, .0022 0, ,0037 0, .0028 0, ,0021 0, .0053 0, ,0024 0, .0299 0.8859 0, .0036 0, ,0092 0, .0035 0.004
Korat 5059 4 0.0019 0, .002 0.0053 0, .0019 0.001 0, .0018 0, ,002 0, .002 0, ,0012 0, .0031 0, ,0025 0, .0019 0.9649 0, .0015 0, ,001 0, .0043 0.0017
Korat 5069 2 0.0014 0, .0022 0.0037 0, .002 0.001 0, .001 0, ,0021 0, .0021 0, ,0025 0, .0032 0, ,0018 0, .0026 0.9658 0, .0027 0, ,001 0, .002 0.0029
Korat 5098 3 0.0019 0, .0033 0.0025 0, .001 0.001 0, .001 0, ,0013 0, .0013 0, ,0011 0, .0021 0, ,0012 0, .0019 0.9746 0, .0012 0, ,001 0, .0019 0.0017
Korat 5175 2 0.0018 0. .0019 0.0053 0. .001 0.001 0. .0013 0. ,0021 0, .0017 0, ,0022 0, .002 0, ,0015 0, .0021 0.9696 0, .002 0, ,001 0, .002 0.0015
Korat 5176 1 0.0031 0, .002 0.0044 0, .0018 0.001 0, .0032 0, ,0024 0, .0025 0, ,0018 0, .0064 0, ,0031 0, .0038 0.9548 0, .0027 0, ,0018 0, .0029 0.0023
Korat 5177 2 0.002 0, .0029 0.0027 0, .0019 0.0012 0, .0014 0, ,004 0, .0022 0, ,0012 0, .0032 0, ,0048 0, .002 0.9616 0, .0031 0, ,0011 0, .0029 0.0018
Korat 5178 4 0.0025 0, .0032 0.0039 0, .001 0.001 0, .0018 0, ,0029 0, .0019 0, ,0014 0, .002 0, ,002 0, .0023 0.9675 0, .0021 0, ,001 0, .0017 0.0018
Korat 5224 1 0.0096 0, .0038 0.0353 0, .1421 0.0034 0, .004 0, ,021 0, .0186 0, ,0076 0, .038 0, ,0049 0, .0131 0.6445 0, .0266 0, ,0094 0, .0076 0.0105
Korat 5237 0 0.0047 0. .0022 0.0044 0. .0377 0.0045 0. .0098 0. ,0036 0, .017 0, ,0028 0, .0045 0, ,0035 0, .0049 0.8773 0, .0084 0, ,0033 0, .0055 0.0059
Korat 5240 2 0.0075 0, .0035 0.011 0, .0576 0.0122 0, .0039 0, , 1226 0, .0067 0, ,0449 0, .0147 0, ,002 0, .0291 0.633 0, .0061 0, ,0093 0, .0218 0.0141
Korat 5242 4 0.014 0, .0026 0.0042 0, .0101 0.0791 0, .002 0, ,0092 0, .0028 0, ,0605 0, .0034 0, ,006 0, .0034 0.7478 0, .0023 0, ,0074 0, .0052 0.04
Korat 5244 3 0.0057 0, .012 0.0171 0, .0095 0.0021 0, .002 0, ,0041 0, .0054 0, ,0021 0, .0232 0, ,0042 0, .0087 0.8595 0, .0055 0, ,003 0, .028 0.0079
Korat 5284 2 0.0043 0, .0044 0.0063 0, .0038 0.0124 0, .0132 0, ,0103 0, .0081 0, ,0055 0, .011 0, ,01 0, .0145 0.0033 0, .0027 0, ,8711 0, .0075 0.0116
Korat 5344 3 0.0051 0. .0018 0.0137 0. .0036 0.0035 0. .0091 0. ,0147 0, .0064 0, ,0061 0, .0094 0, ,002 0, .0108 0.0029 0, .0097 0, ,8823 0, .0144 0.0045
Korat 5481 2 0.0049 0, .0012 0.0053 0, .0152 0.0048 0, .0035 0, ,0043 0, .0267 0, ,0557 0, .0037 0, ,0057 0, .0034 0.002 0, .0064 0, ,8313 0, .0206 0.0052
Korat 5512 3 0.0192 0, .001 0.0035 0, .0015 0.026 0, .0035 0, ,0069 0, .002 0, ,0407 0, .0029 0, ,0027 0, .0018 0.0042 0, .0028 0, ,8697 0, .0063 0.0053
Korat 5514 0 0.0027 0, .0026 0.0078 0, .1579 0.003 0, .004 0, ,0048 0, .007 0, ,0024 0, .012 0, ,002 0, .0157 0.0092 0, .0023 0, ,7572 0, .0049 0.0045
Korat 5595 22 0.004 0, .1207 0.2523 0, .0749 0.004 0, .0033 0, ,0338 0, .0049 0, ,0145 0, .1431 0, ,0036 0, .0701 0.0237 0, .003 0, , 1927 0, .0245 0.0271
Korat 5597 5 0.0042 0. .0251 0.0273 0. .0033 0.0063 0. .0069 0. ,0213 0, .0036 0, ,0075 0, .0118 0, ,0034 0, .0529 0.0051 0, .0049 0, ,7622 0, .0379 0.0162
Korat 6375 2 0.0038 0, .007 0.0217 0, .0071 0.0032 0, .0196 0, ,0103 0, .0063 0, ,0021 0, .0058 0, ,0043 0, .0485 0.0101 0, .0108 0, ,8213 0, .0107 0.0074
Korat 6376 20 0.0068 0, .003 0.0032 0, .0056 0.0129 0, .0288 0, ,0054 0, .006 0, ,0087 0, .0056 0, ,0247 0, .003 0.0044 0, .0026 0, ,8672 0, .0077 0.0044
Korat 6377 15 0.0029 0. .0039 0.0025 0. .0044 0.0071 0. .0051 0. ,0027 0, .0036 0, ,0017 0, .0029 0, ,0031 0, .0026 0.003 0, .003 0, ,9445 0, .0027 0.0043
Korat 6378 7 0.0031 0, .0251 0.0222 0, .002 0.0022 0, .0024 0, ,0206 0, .0113 0, ,0433 0, .012 0, ,0089 0, .0165 0.0235 0, .0075 0, ,7825 0, .0094 0.0075
Table 19 - Population clustering of each pedigreed individual in the database by SNPs at K = 17
Feline ID Missing Groups
Population No. Data 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Siamese 2868 0 0.0406 0 .0044 0.0239 0, .0091 0, ,044 0, .0031 0, ,0097 0, .0034 0, ,0048 0.0125 0.0148 0.0166 0.0155 0.005 0.7727 0, .0028 0.0171
Siamese 6686 2 0.002 0 .0056 0.0049 0, .0029 0, ,004 0, .0712 0, ,0112 0, .0035 0, ,0027 0.0044 0.002 0.0039 0.0083 0.005 0.8617 0, .0028 0.0039
Siamese 6688 4 0.013 0 .0143 0.0047 0. .0061 0. ,0027 0, .0063 0, ,0042 0, .1075 0, ,0282 0.0915 0.0068 0.0103 0.0535 0.0236 0.6112 0, .0045 0.0117
Siamese 6690 2 0.018 0 .0032 0.0023 0, .002 0, ,0029 0, .0051 0, ,0067 0, .0153 0, ,0164 0.0045 0.0041 0.0043 0.0055 0.0157 0.8787 0, .0075 0.0078
Siamese 6696 18 0.5406 0 .0018 0.0035 0, .0026 0, ,002 0, .0397 0, ,0032 0, .0037 0, ,0011 0.0043 0.0017 0.0029 0.0026 0.002 0.3829 0, .0023 0.0031
Siamese 7839 14 0.8253 0 .0174 0.0091 0, .001 0, ,0061 0, .0205 0, ,004 0, .0035 0, ,0028 0.0038 0.0643 0.0094 0.0117 0.0044 0.0064 0, .0064 0.0039
Siamese 8181 18 0.5983 0 .0058 0.0172 0, .001 0, ,0028 0, .006 0, ,005 0, .0021 0, ,0078 0.0035 0.0022 0.015 0.3146 0.0028 0.0029 0, .0087 0.0043
Siamese 8182 8 0.915 0 .0055 0.0102 0, .0032 0, ,0023 0, .0147 0, ,0064 0, .0046 0, ,002 0.0069 0.0017 0.0061 0.0036 0.0032 0.0055 0, .0049 0.0042
Siamese 8184 6 0.821 0 .0218 0.0064 0, .0124 0, ,0037 0, .0023 0, ,0033 0, .0085 0, ,0043 0.0171 0.0033 0.007 0.0049 0.002 0.0625 0, .0123 0.0073
Siamese 8185 8 0.3645 0 .007 0.0472 0, .0054 0, ,0118 0, .0068 0, ,0061 0, .0083 0, ,0025 0.0264 0.003 0.128 0.0069 0.0113 0.0832 0, .2143 0.0674
Siamese 8187 2 0.8651 0 .0037 0.0104 0. .0035 0. ,0033 0, .0037 0, ,0165 0, .015 0, ,0075 0.0067 0.0023 0.0049 0.0325 0.0066 0.0055 0, .0051 0.0077
Siamese 8251 1 0.7731 0 .0072 0.0046 0, .004 0, ,0167 0, .002 0, ,0071 0, .0175 0, ,0816 0.009 0.0053 0.0051 0.004 0.0129 0.0107 0, .0168 0.0224
Siamese 8253 3 0.8016 0 .002 0.012 0, .0994 0, ,0063 0, .0012 0, ,0057 0, .0176 0, ,0052 0.0052 0.0069 0.0037 0.0051 0.0114 0.0042 0, .0061 0.0063
Siamese 8258 4 0.8358 0 .008 0.052 0, .0013 0, ,0024 0, .002 0, ,0183 0, .0028 0, ,0077 0.0097 0.0123 0.0089 0.0165 0.0055 0.002 0, .0081 0.0067
Siamese 8259 0 0.6547 0 .0047 0.0057 0, .0282 0, ,0404 0, .0071 0, ,008 0, .0118 0, ,0075 0.0068 0.0051 0.01 0.0036 0.0049 0.1246 0, .0137 0.0632
Singapura 3428 2 0.9 0. .0079 0.006 0. .0019 0. ,0027 0, .004 0, ,0034 0, .0057 0, ,0022 0.0064 0.0162 0.0083 0.0077 0.0152 0.0018 0, .0056 0.005
Singapura 3919 8 0.7495 0, .002 0.0025 0, .0048 0, ,0088 0, .0153 0, ,0231 0, .004 0, ,0026 0.0032 0.0055 0.0019 0.0031 0.0025 0.1614 0, .0066 0.0031
Singapura 4464 3 0.864 0, .0053 0.0027 0, .0103 0, ,0087 0, .0101 0, ,0076 0, .0067 0, ,002 0.0085 0.0166 0.0057 0.0067 0.0036 0.0277 0, .0078 0.0059
Singapura 4467 0 0.8436 0, .0086 0.0114 0, .0032 0, ,0023 0, .0043 0, ,0059 0, .0041 0, ,0037 0.0791 0.0039 0.0066 0.0045 0.0024 0.0031 0, .0073 0.006
Singapura 4468 0 0.8299 0, .0052 0.0074 0, .0012 0, ,0126 0, .0518 0, ,0036 0, .0051 0, ,0031 0.0063 0.0077 0.0147 0.017 0.0048 0.0147 0, .0039 0.0109
Singapura 4469 1 0.8894 0. .0037 0.0024 0. .0133 0. ,0057 0, .002 0, ,0065 0, .0101 0, ,005 0.004 0.0154 0.0028 0.0029 0.0042 0.0149 0, .0123 0.0054
Singapura 4470 17 0.8528 0, .0193 0.0055 0, .0221 0, ,0041 0, .0104 0, ,0061 0, .0083 0, ,0034 0.0127 0.0018 0.0045 0.0115 0.0053 0.0127 0, .0097 0.0098
Singapura 4471 16 0.0649 0, .0063 0.0545 0, .033 0, ,2708 0, .0044 0, ,0181 0, .0261 0, , 1831 0.0267 0.0136 0.0098 0.0073 0.023 0.0071 0, .0798 0.1715
Singapura 4472 6 0.0051 0, .1693 0.047 0, .0032 0, ,4249 0, .0062 0, ,0704 0, .041 0, ,0874 0.0046 0.0051 0.012 0.0094 0.0187 0.0051 0, .0045 0.086
Singapura 4473 10 0.0193 0, .0049 0.0063 0, .0138 0, ,2706 0, .0159 0, ,347 0, .0294 0, ,0044 0.0444 0.0077 0.0088 0.033 0.0392 0.0043 0, .0204 0.1305
Singapura 4474 18 0.0402 0. .0065 0.02 0. .0023 0. 2262 0, .0572 0, ,0754 0, .0045 0, ,0029 0.0156 0.0042 0.0505 0.3651 0.0042 0.0075 0, .0097 0.1081
Singapura 4485 1 0.0143 0, .0627 0.0307 0, .0033 0, ,3816 0, .0049 0, ,0231 0, .0138 0, ,0794 0.0061 0.0031 0.018 0.2459 0.0281 0.0122 0, .0058 0.067
Singapura 4486 13 0.0046 0, .0032 0.005 0, .0079 0, , 1946 0, .0229 0, ,208 0, .006 0, ,0055 0.016 0.0417 0.0164 0.1886 0.0155 0.1575 0, .0033 0.1032
Singapura 4487 2 0.0064 0, .012 0.0231 0, .0121 0, ,3331 0, .0038 0, ,0161 0, .0542 0, ,0221 0.0358 0.0042 0.0331 0.0119 0.2805 0.0028 0, .0041 0.1445
Singapura 4488 0 0.0044 0, .018 0.1542 0, .0027 0, ,3062 0, .1154 0, ,0068 0, .0076 0, , 1604 0.0059 0.0023 0.0518 0.0184 0.005 0.009 0, .0046 0.1272
Singapura 6597 0 0.0069 0. .003 0.2742 0. .0039 0. ,271 0, .0051 0, ,0774 0, .0194 0, ,0071 0.0199 0.0051 0.0762 0.0514 0.034 0.0111 0, .0151 0.1191
Singapura 6975 2 0.0134 0, .073 0.0316 0, .0221 0, 1489 0, .0314 0, ,0889 0, .0072 0, , 1075 0.0161 0.023 0.0426 0.214 0.0108 0.0101 0, .0117 0.1476
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
USA-NY 2547 1 0.821 0.021 0.037 0.08 0.041 Brazil 7966 1 0.858 0.024 0.085 0.012 0.021
USA-NY 2559 0 0.556 0.088 0.156 0.187 0.012 Brazil 7968 22 0.775 0.026 0.044 0.12 0.035
USA-NY 2568 0 0.964 0.01 0.011 0.006 0.009 Brazil 7969 0 0.953 0.008 0.016 0.011 0.012
USA-NY 2569 1 0.921 0.01 0.017 0.027 0.025 Brazil 7970 0 0.934 0.013 0.015 0.023 0.015
USA-NY 2572 0 0.903 0.01 0.046 0.02 0.022 Brazil 7971 0 0.924 0.012 0.025 0.015 0.023
USA-NY 2578 20 0.768 0.017 0.084 0.05 0.082 Brazil 7972 0 0.865 0.012 0.096 0.014 0.013
USA-NY 2590 0 0.901 0.023 0.043 0.022 0.012 Brazil 7973 0 0.915 0.015 0.026 0.028 0.016
USA-NY 2591 1 0.929 0.01 0.022 0.01 0.029 Brazil 7974 3 0.869 0.022 0.073 0.022 0.014
USA-NY 2597 1 0.864 0.018 0.032 0.024 0.062 Brazil 7975 3 0.888 0.013 0.036 0.04 0.022
USA-MS 9971 2 0.896 0.039 0.023 0.026 0.016 Brazil 7976 0 0.902 0.019 0.034 0.025 0.02
USA-MS 9972 2 0.778 0.027 0.104 0.019 0.072 Brazil 7977 1 0.895 0.006 0.059 0.029 0.011
USA-MS 9974 2 0.687 0.259 0.03 0.011 0.014 Brazil 7978 1 0.804 0.02 0.052 0.101 0.023
USA-MS 9977 4 0.941 0.007 0.024 0.018 0.011 Brazil 7979 1 0.861 0.043 0.041 0.034 0.021
USA-MS 9980 1 0.878 0.034 0.034 0.023 0.032 Brazil 7980 2 0.64 0.014 0.252 0.058 0.036
USA-MS 9983 1 0.924 0.007 0.024 0.017 0.029 Brazil 7981 2 0.768 0.009 0.025 0.188 0.009
USA-MS 9985 2 0.706 0.226 0.021 0.013 0.034 Brazil 7982 15 0.707 0.141 0.037 0.093 0.022
USA-MS 9987 2 0.641 0.084 0.187 0.071 0.018 Brazil 7983 1 0.659 0.074 0.15 0.062 0.054
USA-MS 9989 2 0.933 0.025 0.017 0.013 0.012 Brazil 7984 6 0.614 0.25 0.054 0.07 0.013
USA-MS 9992 2 0.883 0.013 0.051 0.017 0.036 Brazil 7985 2 0.705 0.054 0.145 0.084 0.012
USA-HI 5366 1 0.751 0.026 0.042 0.156 0.025 Brazil 7986 2 0.755 0.136 0.073 0.026 0.01
USA-HI 5367 0 0.775 0.054 0.024 0.08 0.068 Brazil 7987 1 0.854 0.025 0.091 0.02 0.01
USA-HI 5371 0 0.898 0.023 0.047 0.012 0.019 Brazil 7988 0 0.747 0.073 0.041 0.126 0.013
USA-HI 5372 0 0.564 0.043 0.263 0.031 0.099 Brazil 7989 0 0.568 0.376 0.023 0.018 0.015
USA-HI 5379 0 0.858 0.014 0.064 0.032 0.032 Brazil 7990 0 0.717 0.222 0.028 0.019 0.014
USA-HI 5380 1 0.941 0.005 0.032 0.014 0.007 Finland 8077 8 0.86 0.011 0.075 0.024 0.03
USA-HI 5383 1 0.39 0.054 0.039 0.101 0.416 Finland 8084 6 0.824 0.008 0.049 0.047 0.073
USA-HI 5384 2 0.879 0.012 0.044 0.032 0.034 Finland 8086 4 0.829 0.035 0.072 0.039 0.024
USA-HI 5401 1 0.938 0.016 0.021 0.013 0.013 Finland 8089 4 0.688 0.029 0.097 0.075 0.111
USA-HI 5402 0 0.838 0.073 0.025 0.047 0.017 Finland 8093 16 0.863 0.013 0.032 0.055 0.037
Brazil 7961 0 0.861 0.022 0.067 0.029 0.021 Finland 8094 3 0.904 0.01 0.028 0.018 0.04
Brazil 7962 2 0.763 0.06 0.095 0.057 0.026 Finland 8096 3 0.941 0.005 0.017 0.008 0.028
Brazil 7963 15 0.544 0.3 0.095 0.047 0.014 Finland 8107 22 0.953 0.006 0.014 0.011 0.016
Brazil 7964 1 0.871 0.009 0.077 0.027 0.016 Finland 8110 5 0.96 0.009 0.015 0.007 0.01
Brazil 7965 18 0.934 0.015 0.013 0.024 0.014 Finland 8116 8 0.857 0.04 0.031 0.045 0.028
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Finland 8120 19 0.933 0.015 0.02 0.023 0.008 Italy-Milan 8062 1 0.39 0.034 0.525 0.011 0.04
Germany 8711 2 0.884 0.009 0.052 0.038 0.016 Italy-Milan 8065 4 0.625 0.013 0.309 0.015 0.039
Germany 8712 3 0.931 0.008 0.023 0.013 0.026 Italy-Milan 8066 0 0.329 0.072 0.489 0.018 0.092
Germany 8713 2 0.681 0.012 0.264 0.027 0.016 Italy-Milan 8067 2 0.553 0.06 0.304 0.027 0.055
Germany 8714 2 0.744 0.021 0.128 0.03 0.077 Italy-Milan 8068 0 0.599 0.017 0.311 0.03 0.042
Germany 8715 4 0.914 0.006 0.033 0.012 0.034 Italy-Milan 8069 0 0.692 0.09 0.132 0.046 0.04
Germany 8716 4 0.898 0.021 0.027 0.033 0.021 Italy-Milan 8071 2 0.732 0.026 0.161 0.05 0.03
Germany 8717 12 0.899 0.015 0.037 0.019 0.03 Italy-Milan 8072 2 0.315 0.275 0.273 0.117 0.02
Germany 8720 2 0.271 0.657 0.046 0.01 0.017 Italy-Milan 8073 0 0.753 0.011 0.183 0.023 0.031
Germany 8721 10 0.909 0.014 0.052 0.013 0.013 Italy-Milan 8074 1 0.71 0.167 0.091 0.018 0.013
Germany 8727 0 0.937 0.01 0.02 0.022 0.01 Italy-Rome 8586 1 0.475 0.012 0.439 0.031 0.042
Germany 8728 10 0.857 0.018 0.045 0.025 0.054 Italy-Rome 8589 2 0.903 0.016 0.046 0.017 0.019
Germany 8729 1 0.948 0.011 0.013 0.013 0.015 Italy-Rome 8592 1 0.54 0.026 0.123 0.127 0.185
Germany 8730 22 0.767 0.022 0.015 0.173 0.023 Italy-Rome 8594 1 0.783 0.033 0.116 0.051 0.017
Germany 8731 12 0.953 0.005 0.014 0.015 0.013 Italy-Rome 8595 0 0.705 0.064 0.147 0.033 0.051
Germany 8732 3 0.892 0.006 0.073 0.01 0.019 Italy-Rome 8596 1 0.353 0.02 0.585 0.017 0.025
Germany 8733 14 0.833 0.034 0.047 0.027 0.059 Italy-Rome 8597 0 0.779 0.077 0.07 0.041 0.033
Germany 8734 0 0.938 0.007 0.033 0.008 0.016 Italy-Rome 8599 0 0.925 0.023 0.02 0.017 0.015
Germany 8735 0 0.851 0.021 0.082 0.027 0.017 Italy-Rome 8601 2 0.667 0.034 0.198 0.074 0.026
Germany 8736 0 0.933 0.008 0.041 0.011 0.007 Italy-Rome 8602 2 0.807 0.045 0.087 0.024 0.037
Germany 8737 2 0.944 0.01 0.016 0.012 0.019 Italy-Rome 8603 0 0.864 0.03 0.049 0.042 0.016
Germany 8738 10 0.866 0.008 0.097 0.012 0.018 Italy-Rome 8604 2 0.241 0.01 0.591 0.139 0.018
Germany 8739 0 0.913 0.005 0.065 0.008 0.009 Italy-Rome 8609 1 0.898 0.011 0.059 0.017 0.014
Germany 8741 12 0.147 0.008 0.813 0.012 0.02 Italy-Rome 8610 1 0.529 0.051 0.245 0.1 0.075
Germany 8742 10 0.902 0.025 0.047 0.011 0.014 Italy-Rome 8611 2 0.711 0.049 0.173 0.021 0.045
Germany 8744 6 0.555 0.088 0.324 0.024 0.008 Turkey 6477 7 0.206 0.007 0.754 0.008 0.024
Germany 8745 22 0.918 0.008 0.045 0.013 0.016 Turkey 6478 12 0.065 0.055 0.673 0.087 0.12
Germany 8746 0 0.896 0.025 0.035 0.016 0.028 Turkey 6480 11 0.039 0.012 0.917 0.011 0.022
Germany 8747 12 0.959 0.01 0.014 0.008 0.009 Turkey 6481 12 0.067 0.647 0.064 0.08 0.142
Germany 8749 0 0.939 0.012 0.016 0.016 0.017 Turkey 6482 14 0.047 0.008 0.893 0.04 0.012
Italy-Milan 8050 0 0.712 0.04 0.139 0.017 0.092 Turkey 6484 7 0.087 0.019 0.855 0.021 0.019
Italy-Milan 8057 1 0.619 0.116 0.092 0.047 0.127 Turkey 6486 8 0.729 0.025 0.193 0.019 0.035
Italy-Milan 8060 0 0.657 0.074 0.037 0.018 0.213 Turkey 6487 15 0.279 0.012 0.648 0.035 0.025
Italy-Milan 8061 2 0.653 0.231 0.083 0.016 0.017 Turkey 6488 12 0.078 0.011 0.778 0.059 0.075
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Turkey 6491 15 0.018 0.482 0.022 0.04 0.439 Turkey 6750 3 0.398 0.025 0.522 0.025 0.03
Turkey 6494 11 0.227 0.098 0.551 0.044 0.08 Turkey 6753 0 0.333 0.014 0.565 0.029 0.059
Turkey 6496 12 0.062 0.038 0.793 0.058 0.049 Turkey 6754 2 0.335 0.018 0.466 0.059 0.122
Turkey 6499 12 0.625 0.026 0.282 0.037 0.031 Turkey 6755 1 0.271 0.007 0.656 0.019 0.046
Turkey 6500 15 0.261 0.01 0.576 0.066 0.088 Turkey 6756 0 0.16 0.012 0.786 0.023 0.019
Turkey 6502 6 0.142 0.024 0.647 0.083 0.104 Turkey 6758 1 0.082 0.03 0.826 0.046 0.016
Turkey 6503 1 0.161 0.012 0.78 0.018 0.03 Turkey 6759 2 0.424 0.015 0.46 0.034 0.067
Turkey 6507 14 0.03 0.016 0.891 0.04 0.023 Turkey 6760 1 0.654 0.009 0.201 0.023 0.113
Turkey 6510 10 0.035 0.187 0.676 0.068 0.033 Cyprus 10128 3 0.061 0.036 0.805 0.07 0.027
Turkey 6512 15 0.2 0.01 0.381 0.034 0.374 Cyprus 10129 0 0.638 0.065 0.112 0.074 0.112
Turkey 6513 14 0.731 0.038 0.13 0.044 0.057 Cyprus 10130 2 0.06 0.009 0.909 0.011 0.011
Turkey 6514 9 0.012 0.95 0.014 0.008 0.016 Cyprus 10131 1 0.326 0.039 0.29 0.312 0.033
Turkey 6516 12 0.94 0.012 0.023 0.013 0.012 Cyprus 10132 0 0.009 0.096 0.773 0.042 0.08
Turkey 6519 7 0.574 0.02 0.183 0.11 0.112 Cyprus 10133 0 0.162 0.125 0.653 0.044 0.017
Turkey 6520 15 0.229 0.012 0.658 0.025 0.076 Cyprus 10134 0 0.279 0.02 0.638 0.029 0.034
Turkey 6521 12 0.707 0.018 0.198 0.049 0.029 Cyprus 10135 2 0.2 0.019 0.562 0.032 0.186
Turkey 6729 1 0.101 0.029 0.05 0.115 0.704 Cyprus 10136 2 0.437 0.01 0.283 0.031 0.24
Turkey 6730 1 0.039 0.009 0.928 0.009 0.015 Cyprus 10137 1 0.049 0.01 0.908 0.013 0.02
Turkey 6731 2 0.363 0.023 0.475 0.035 0.104 Cyprus 10138 2 0.017 0.053 0.883 0.022 0.025
Turkey 6732 0 0.024 0.077 0.803 0.055 0.041 Cyprus 10139 3 0.08 0.045 0.749 0.098 0.028
Turkey 6733 3 0.051 0.022 0.845 0.038 0.044 Cyprus 10140 0 0.067 0.025 0.844 0.05 0.015
Turkey 6734 0 0.023 0.026 0.808 0.015 0.128 Cyprus 10141 0 0.035 0.01 0.929 0.014 0.012
Turkey 6735 2 0.024 0.006 0.948 0.009 0.013 Cyprus 10142 1 0.042 0.06 0.789 0.02 0.089
Turkey 6736 1 0.288 0.011 0.634 0.018 0.048 Cyprus 10143 0 0.016 0.019 0.871 0.076 0.017
Turkey 6738 2 0.183 0.004 0.798 0.006 0.008 Cyprus 10144 2 0.04 0.039 0.566 0.041 0.313
Turkey 6739 2 0.327 0.02 0.563 0.018 0.073 Cyprus 10145 1 0.107 0.022 0.794 0.047 0.029
Turkey 6740 0 0.961 0.006 0.013 0.01 0.01 Cyprus 10146 0 0.032 0.008 0.69 0.024 0.246
Turkey 6741 0 0.094 0.839 0.019 0.024 0.023 Cyprus 10147 1 0.129 0.014 0.766 0.052 0.039
Turkey 6742 2 0.273 0.025 0.479 0.032 0.191 Cyprus 10148 0 0.054 0.033 0.843 0.025 0.045
Turkey 6743 1 0.193 0.014 0.771 0.009 0.012 Cyprus 10149 2 0.039 0.046 0.833 0.02 0.063
Turkey 6745 0 0.068 0.009 0.824 0.037 0.063 Cyprus 10150 0 0.196 0.029 0.667 0.071 0.037
Turkey 6746 1 0.233 0.259 0.127 0.22 0.161 Cyprus 10151 2 0.022 0.024 0.9 0.031 0.022
Turkey 6748 1 0.186 0.054 0.455 0.046 0.258 Cyprus 10152 2 0.375 0.008 0.525 0.02 0.073
Turkey 6749 0 0.042 0.026 0.887 0.02 0.027 Cyprus 10153 1 0.031 0.008 0.732 0.186 0.043
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Cyprus 10154 2 0.035 0.048 0.869 0.027 0.02 Lebanon 10265 10 0.035 0.022 0.884 0.028 0.031
Cyprus 10155 2 0.026 0.038 0.888 0.027 0.021 Lebanon 10266 5 0.013 0.06 0.852 0.054 0.022
Cyprus 10156 5 0.018 0.025 0.84 0.017 0.099 Lebanon 10267 12 0.865 0.016 0.038 0.017 0.065
Cyprus 10157 2 0.106 0.023 0.529 0.019 0.323 Lebanon 10268 17 0.049 0.082 0.716 0.116 0.037
Lebanon 10235 21 0.039 0.084 0.688 0.098 0.091 Lebanon 10270 10 0.236 0.424 0.276 0.034 0.03
Lebanon 10236 25 0.018 0.021 0.786 0.132 0.043 Lebanon 10271 1 0.021 0.154 0.637 0.045 0.143
Lebanon 10237 19 0.031 0.06 0.583 0.266 0.06 Lebanon 10273 4 0.076 0.064 0.59 0.23 0.041
Lebanon 10238 2 0.353 0.055 0.459 0.055 0.077 Lebanon 10274 3 0.145 0.019 0.782 0.041 0.014
Lebanon 10239 16 0.056 0.014 0.821 0.025 0.084 Lebanon 10276 4 0.029 0.011 0.829 0.023 0.107
Lebanon 10240 20 0.049 0.025 0.825 0.031 0.069 Lebanon 10277 4 0.256 0.08 0.518 0.107 0.039
Lebanon 10241 5 0.038 0.033 0.621 0.148 0.16 Lebanon 10278 3 0.029 0.012 0.713 0.044 0.202
Lebanon 10242 0 0.192 0.159 0.567 0.042 0.04 Lebanon 10279 2 0.077 0.02 0.653 0.037 0.213
Lebanon 10243 1 0.057 0.028 0.742 0.043 0.131 Lebanon 10280 2 0.051 0.054 0.767 0.089 0.04
Lebanon 10244 18 0.04 0.032 0.819 0.058 0.051 Lebanon 10281 7 0.09 0.015 0.825 0.038 0.032
Lebanon 10245 6 0.058 0.03 0.715 0.02 0.178 Lebanon 10282 2 0.062 0.104 0.694 0.108 0.031
Lebanon 10246 18 0.201 0.078 0.564 0.035 0.122 Lebanon 10283 16 0.019 0.019 0.869 0.031 0.063
Lebanon 10247 26 0.017 0.04 0.764 0.048 0.131 Lebanon 10284 14 0.091 0.041 0.581 0.062 0.225
Lebanon 10248 22 0.031 0.053 0.709 0.11 0.097 Lebanon 10285 1 0.027 0.028 0.901 0.007 0.036
Lebanon 10249 18 0.378 0.044 0.506 0.031 0.04 Lebanon 10286 3 0.253 0.212 0.232 0.2 0.104
Lebanon 10250 27 0.051 0.014 0.881 0.022 0.032 Lebanon 10287 1 0.334 0.026 0.499 0.064 0.078
Lebanon 10251 4 0.029 0.025 0.814 0.038 0.094 Lebanon 10288 25 0.34 0.037 0.277 0.283 0.063
Lebanon 10252 14 0.261 0.061 0.193 0.031 0.455 Lebanon 10289 2 0.021 0.024 0.812 0.048 0.094
Lebanon 10253 4 0.047 0.163 0.108 0.027 0.655 Lebanon 10290 3 0.044 0.037 0.772 0.05 0.097
Lebanon 10254 13 0.043 0.015 0.821 0.096 0.025 Lebanon 10291 8 0.097 0.053 0.611 0.09 0.149
Lebanon 10255 7 0.124 0.125 0.564 0.043 0.144 Lebanon 10292 6 0.096 0.097 0.664 0.024 0.119
Lebanon 10256 10 0.191 0.032 0.336 0.036 0.405 Lebanon 10294 9 0.045 0.111 0.751 0.07 0.024
Lebanon 10257 3 0.434 0.169 0.352 0.028 0.018 Lebanon 10295 6 0.117 0.175 0.512 0.112 0.083
Lebanon 10258 19 0.017 0.037 0.616 0.227 0.103 Lebanon 10297 5 0.093 0.04 0.57 0.043 0.254
Lebanon 10259 0 0.043 0.5 0.339 0.104 0.014 Lebanon 10298 7 0.036 0.026 0.786 0.045 0.107
Lebanon 10260 17 0.166 0.023 0.756 0.023 0.033 Lebanon 10299 20 0.144 0.047 0.66 0.035 0.113
Lebanon 10261 14 0.02 0.118 0.776 0.058 0.027 Lebanon 10300 25 0.06 0.041 0.764 0.045 0.091
Lebanon 10262 22 0.015 0.013 0.87 0.024 0.077 Israel 4962 0 0.259 0.016 0.414 0.097 0.213
Lebanon 10263 2 0.078 0.025 0.707 0.035 0.154 Israel 4963 0 0.122 0.019 0.758 0.059 0.041
Lebanon 10264 3 0.188 0.035 0.583 0.09 0.105 Israel 4964 0 0.018 0.042 0.68 0.028 0.232
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Israel 4966 2 0.046 0.025 0.878 0.026 0.025 Israel 5003 1 0.307 0.259 0.151 0.101 0.182
Israel 4967 1 0.302 0.029 0.316 0.018 0.335 Israel 5004 0 0.023 0.156 0.611 0.052 0.158
Israel 4968 2 0.016 0.029 0.876 0.046 0.034 Israel 5005 0 0.218 0.012 0.707 0.035 0.028
Israel 4969 1 0.661 0.162 0.045 0.098 0.033 Israel 5006 1 0.089 0.053 0.72 0.024 0.113
Israel 4970 0 0.074 0.032 0.816 0.047 0.031 Israel 5007 1 0.033 0.103 0.711 0.117 0.036
Israel 4971 0 0.026 0.011 0.919 0.012 0.032 Israel 5008 0 0.356 0.115 0.374 0.097 0.058
Israel 4972 0 0.11 0.027 0.61 0.14 0.113 Israel 5009 0 0.03 0.292 0.534 0.028 0.116
Israel 4973 2 0.063 0.034 0.787 0.064 0.053 Israel 5010 1 0.042 0.01 0.886 0.011 0.051
Israel 4974 1 0.05 0.027 0.822 0.053 0.048 Israel 5011 0 0.016 0.024 0.881 0.05 0.03
Israel 4975 0 0.103 0.026 0.793 0.031 0.047 Egypt-Cairo 8190 0 0.058 0.054 0.795 0.048 0.045
Israel 4976 0 0.136 0.054 0.511 0.061 0.239 Egypt-Cairo 8192 2 0.142 0.014 0.796 0.017 0.031
Israel 4977 0 0.378 0.029 0.29 0.022 0.281 Egypt-Cairo 8193 0 0.384 0.049 0.429 0.044 0.094
Israel 4978 1 0.037 0.031 0.695 0.096 0.141 Egypt-Cairo 8196 1 0.029 0.039 0.774 0.065 0.094
Israel 4979 1 0.058 0.033 0.583 0.078 0.248 Egypt-Cairo 8203 1 0.029 0.012 0.922 0.012 0.025
Israel 4980 1 0.31 0.019 0.578 0.021 0.071 Egypt-Cairo 8215 1 0.085 0.044 0.698 0.064 0.109
Israel 4981 2 0.109 0.07 0.192 0.565 0.063 Egypt-Cairo 8198 2 0.028 0.047 0.867 0.021 0.038
Israel 4982 3 0.039 0.057 0.819 0.023 0.061 Egypt-Cairo 8194 0 0.106 0.059 0.738 0.035 0.062
Israel 4983 0 0.109 0.138 0.549 0.076 0.129 Egypt-Cairo 8211 10 0.025 0.008 0.938 0.012 0.017
Israel 4984 2 0.238 0.072 0.37 0.027 0.292 Egypt-Cairo 8216 1 0.039 0.136 0.793 0.01 0.022
Israel 4985 16 0.099 0.021 0.783 0.075 0.022 Egypt-Cairo 8195 1 0.165 0.013 0.772 0.022 0.029
Israel 4986 1 0.057 0.162 0.689 0.027 0.065 Egypt-Cairo 8199 9 0.051 0.015 0.863 0.045 0.026
Israel 4988 0 0.092 0.107 0.705 0.065 0.03 Egypt-Cairo 8200 16 0.038 0.029 0.885 0.022 0.026
Israel 4989 4 0.091 0.104 0.604 0.18 0.02 Egypt-Cairo 8201 0 0.205 0.123 0.6 0.018 0.053
Israel 4990 2 0.051 0.249 0.341 0.331 0.029 Egypt-Cairo 8202 2 0.033 0.679 0.111 0.055 0.122
Israel 4992 6 0.063 0.011 0.519 0.045 0.362 Egypt-Cairo 8204 2 0.023 0.012 0.93 0.023 0.012
Israel 4993 10 0.051 0.03 0.827 0.036 0.055 Egypt-Cairo 8208 0 0.011 0.027 0.839 0.012 0.11
Israel 4994 2 0.016 0.013 0.94 0.013 0.018 Egypt-Cairo 8210 3 0.032 0.014 0.731 0.148 0.074
Israel 4995 1 0.129 0.147 0.468 0.242 0.015 Egypt-Cairo 8214 2 0.061 0.225 0.599 0.032 0.083
Israel 4996 0 0.029 0.014 0.742 0.193 0.022 Egypt-Cairo 8191 1 0.024 0.014 0.928 0.017 0.018
Israel 4997 0 0.045 0.17 0.563 0.191 0.031 Egypt-Cairo 8197 0 0.032 0.043 0.897 0.012 0.015
Israel 4998 0 0.21 0.021 0.404 0.032 0.333 Egypt-Cairo 8205 0 0.011 0.011 0.766 0.06 0.151
Israel 5000 1 0.025 0.013 0.907 0.025 0.03 Egypt-Cairo 8206 1 0.01 0.044 0.856 0.05 0.04
Israel 5001 1 0.376 0.051 0.478 0.076 0.02 Egypt-Cairo 8207 2 0.023 0.1 0.813 0.033 0.031
Israel 5002 0 0.072 0.117 0.748 0.047 0.015 Egypt-Cairo 8209 1 0.013 0.018 0.883 0.027 0.059
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Cairo 8212 0 0.04 0.095 0.787 0.016 0.062 Egypt-Cairo 10030 1 0.013 0.012 0.946 0.014 0.015
Egypt-Cairo 8213 0 0.043 0.053 0.832 0.023 0.049 Egypt-Cairo 10031 3 0.016 0.015 0.93 0.027 0.014
Egypt-Cairo 9942 3 0.033 0.02 0.866 0.051 0.031 Egypt-Cairo 10032 0 0.03 0.015 0.903 0.016 0.036
Egypt-Cairo 9943 0 0.182 0.418 0.375 0.011 0.014 Egypt-Cairo 10033 1 0.014 0.016 0.881 0.011 0.078
Egypt-Cairo 9944 4 0.583 0.053 0.049 0.053 0.263 Egypt-Cairo 10034 1 0.059 0.016 0.879 0.022 0.024
Egypt-Cairo 9945 0 0.009 0.044 0.864 0.024 0.059 Egypt-Cairo 10035 4 0.033 0.024 0.762 0.053 0.128
Egypt-Cairo 9946 0 0.029 0.024 0.898 0.033 0.016 Egypt-Cairo 10037 5 0.372 0.016 0.532 0.043 0.037
Egypt-Cairo 9947 2 0.017 0.038 0.786 0.023 0.137 Egypt-Cairo 10042 1 0.116 0.026 0.784 0.058 0.017
Egypt-Cairo 9948 0 0.157 0.017 0.795 0.011 0.02 Egypt-Cairo 10043 1 0.059 0.02 0.822 0.015 0.084
Egypt-Cairo 9949 0 0.029 0.2 0.708 0.045 0.018 Egypt-Cairo 10044 4 0.036 0.019 0.819 0.091 0.034
Egypt-Cairo 9950 1 0.046 0.009 0.921 0.012 0.012 Egypt-Cairo 10045 1 0.099 0.008 0.865 0.013 0.015
Egypt-Cairo 9951 2 0.024 0.095 0.756 0.026 0.099 Egypt-Cairo 10046 0 0.021 0.023 0.891 0.024 0.04
Egypt-Cairo 9952 1 0.01 0.013 0.667 0.021 0.289 Egypt-Cairo 10047 0 0.016 0.019 0.921 0.016 0.029
Egypt-Cairo 9953 4 0.659 0.087 0.143 0.063 0.048 Egypt-Cairo 10048 1 0.018 0.059 0.775 0.099 0.049
Egypt-Cairo 9954 0 0.028 0.52 0.405 0.032 0.015 Egypt-Cairo 10083 25 0.054 0.012 0.792 0.095 0.047
Egypt-Cairo 9955 3 0.187 0.047 0.665 0.029 0.072 Egypt-Cairo 10040 3 0.024 0.02 0.89 0.032 0.034
Egypt-Cairo 9956 5 0.021 0.252 0.605 0.106 0.016 Egypt-Cairo 10041 1 0.012 0.016 0.733 0.047 0.192
Egypt-Cairo 9957 1 0.241 0.025 0.39 0.061 0.282 Egypt-Cairo 10049 10 0.028 0.059 0.838 0.045 0.029
Egypt-Cairo 9958 1 0.02 0.141 0.784 0.023 0.032 Egypt-Cairo 10084 8 0.109 0.034 0.799 0.039 0.019
Egypt-Cairo 9959 2 0.075 0.224 0.376 0.073 0.252 Egypt-Cairo 10085 18 0.056 0.038 0.884 0.01 0.012
Egypt-Cairo 9960 1 0.015 0.044 0.881 0.026 0.035 Egypt-Cairo 10087 4 0.133 0.009 0.799 0.023 0.035
Egypt-Cairo 9961 5 0.024 0.457 0.362 0.12 0.037 Egypt-Cairo 10090 3 0.105 0.042 0.77 0.022 0.062
Egypt-Cairo 9962 2 0.154 0.065 0.744 0.023 0.014 Egypt-Cairo 9968 0 0.031 0.017 0.822 0.095 0.034
Egypt-Cairo 9963 4 0.032 0.021 0.886 0.036 0.024 Egypt-Asuit 10091 1 0.025 0.015 0.918 0.025 0.017
Egypt-Cairo 9964 2 0.048 0.118 0.726 0.033 0.075 Egypt-Asuit 10093 4 0.061 0.01 0.904 0.015 0.011
Egypt-Cairo 10021 8 0.024 0.021 0.926 0.01 0.018 Egypt-Asuit 10094 4 0.059 0.017 0.878 0.03 0.016
Egypt-Cairo 10022 1 0.015 0.016 0.914 0.021 0.035 Egypt-Asuit 10095 16 0.159 0.022 0.78 0.025 0.015
Egypt-Cairo 10023 0 0.013 0.014 0.891 0.011 0.071 Egypt-Asuit 10096 2 0.037 0.026 0.821 0.103 0.013
Egypt-Cairo 10024 2 0.014 0.006 0.966 0.007 0.007 Egypt-Asuit 10098 2 0.091 0.01 0.878 0.012 0.009
Egypt-Cairo 10025 2 0.024 0.026 0.784 0.055 0.111 Egypt-Asuit 10099 0 0.03 0.008 0.922 0.022 0.018
Egypt-Cairo 10026 21 0.099 0.023 0.803 0.06 0.015 Egypt-Asuit 10100 2 0.164 0.064 0.635 0.103 0.033
Egypt-Cairo 10027 1 0.021 0.016 0.928 0.017 0.018 Egypt-Asuit 10101 2 0.018 0.026 0.914 0.02 0.021
Egypt-Cairo 10028 1 0.069 0.01 0.877 0.018 0.026 Egypt-Asuit 10102 2 0.017 0.015 0.936 0.017 0.015
Egypt-Cairo 10029 4 0.037 0.014 0.91 0.014 0.025 Egypt- Luxor 10038 1 0.02 0.075 0.858 0.027 0.021
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Luxor 10039 6 0.012 0.035 0.904 0.035 0.013 Simbel
Egypt-Luxor 10050 2 0.012 0.042 0.895 0.032 0.02 Egypt-Abu
Egypt-Luxor 10051 1 0.013 0.018 0.856 0.093 0.019 Simbel 10092 2 0.048 0.008 0.908 0.02 0.016
Egypt-Luxor 10052 14 0.026 0.027 0.885 0.05 0.011 Iraq-West 9587 12 0.148 0.012 0.159 0.031 0.65
Egypt-Luxor 10053 3 0.015 0.071 0.612 0.157 0.144 Iraq-West 10202 2 0.063 0.013 0.391 0.018 0.515
Egypt-Luxor 10054 2 0.014 0.01 0.903 0.024 0.049 Iraq-West 10204 13 0.086 0.013 0.271 0.022 0.608
Egypt-Luxor 10055 2 0.011 0.062 0.863 0.044 0.021 Iraq-West 11854 23 0.058 0.064 0.141 0.044 0.692
Egypt-Luxor 10056 2 0.072 0.069 0.794 0.033 0.032 Iraq-West 11860 8 0.048 0.014 0.196 0.071 0.671
Egypt-Luxor 10057 13 0.029 0.011 0.91 0.035 0.015 Iraq-West 11861 2 0.031 0.056 0.061 0.033 0.819
Egypt-Luxor 10058 8 0.031 0.016 0.873 0.036 0.044 Iraq-West 11863 2 0.066 0.011 0.174 0.012 0.737
Egypt-Luxor 10060 5 0.033 0.022 0.912 0.02 0.012 Iraq-West 11864 1 0.098 0.021 0.144 0.015 0.722
Egypt-Luxor 10061 0 0.055 0.046 0.857 0.029 0.014 Iraq-West 11888 2 0.043 0.301 0.062 0.038 0.556
Egypt-Luxor 10062 3 0.028 0.013 0.885 0.015 0.058 Iraq-West 11889 3 0.029 0.009 0.102 0.013 0.848
Egypt-Luxor 10063 0 0.293 0.049 0.435 0.12 0.103 Iraq-West 11890 20 0.05 0.038 0.126 0.048 0.738
Egypt-Luxor 10064 1 0.138 0.016 0.814 0.015 0.017 Iraq-West 11891 18 0.028 0.041 0.078 0.029 0.824
Egypt-Luxor 10065 0 0.031 0.035 0.8 0.052 0.082 Iraq-Baghdad 11847 0 0.026 0.009 0.126 0.017 0.823
Egypt-Luxor 10066 4 0.048 0.066 0.827 0.039 0.02 Iraq-Baghdad 11848 1 0.04 0.03 0.071 0.017 0.842
Egypt-Luxor 10067 4 0.027 0.013 0.875 0.033 0.052 Iraq-Baghdad 11849 0 0.078 0.006 0.282 0.013 0.621
Egypt-Luxor 10068 9 0.104 0.019 0.832 0.026 0.019 Iraq-Baghdad 11850 1 0.072 0.061 0.077 0.033 0.757
Egypt-Luxor 10069 3 0.025 0.009 0.774 0.036 0.157 Iraq-Baghdad 11852 18 0.015 0.022 0.021 0.018 0.924
Egypt-Luxor 10070 2 0.058 0.044 0.856 0.028 0.014 Iraq-Baghdad 11853 9 0.02 0.096 0.338 0.031 0.515
Egypt-Luxor 10071 4 0.019 0.014 0.919 0.012 0.036 Iraq-Baghdad 11855 22 0.024 0.027 0.078 0.023 0.849
Egypt-Luxor 10072 2 0.032 0.021 0.872 0.034 0.04 Iraq-Baghdad 11856 1 0.063 0.015 0.132 0.01 0.78
Egypt-Luxor 10073 0 0.928 0.006 0.019 0.024 0.023 Iraq-Baghdad 11857 2 0.114 0.01 0.127 0.021 0.728
Egypt-Luxor 10074 0 0.021 0.008 0.945 0.008 0.019 Iraq-Baghdad 11858 0 0.016 0.085 0.243 0.059 0.598
Egypt-Luxor 10079 6 0.073 0.018 0.873 0.019 0.017 Iraq-Baghdad 11859 3 0.055 0.013 0.091 0.023 0.818
Egypt-Luxor 10080 6 0.012 0.023 0.931 0.022 0.013 Iraq-Baghdad 11862 1 0.048 0.009 0.333 0.012 0.599
Egypt-Abu Iraq-Baghdad 11865 2 0.036 0.048 0.313 0.082 0.521
Simbel 10076 11 0.057 0.03 0.813 0.06 0.04 Iraq-Baghdad 11868 10 0.018 0.123 0.058 0.048 0.752
Egypt-Abu Iraq-Baghdad 11869 8 0.054 0.014 0.117 0.023 0.793
Simbel 10077 18 0.02 0.009 0.925 0.024 0.021 Iraq-Baghdad 11870 1 0.26 0.03 0.36 0.018 0.333
Egypt-Abu Iraq-Baghdad 11871 2 0.138 0.012 0.184 0.089 0.577
Simbel 10081 19 0.047 0.023 0.841 0.017 0.072 Iraq-Baghdad 11872 4 0.021 0.011 0.023 0.011 0.934
Egypt-Abu 10089 2 0.039 0.019 0.899 0.024 0.019 Iraq-Baghdad 11873 2 0.05 0.03 0.367 0.027 0.526
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5 raq-Baghdad 11874 0 0.042 0.018 0.215 0.102 0.624 Iran 9440 1 0.013 0.007 0.016 0.011 0.953 raq-Baghdad 11875 1 0.025 0.018 0.205 0.011 0.742 Iran 9441 1 0.008 0.007 0.009 0.015 0.961 raq-Baghdad 11876 1 0.017 0.064 0.078 0.012 0.83 Iran 9442 2 0.008 0.018 0.024 0.029 0.922 raq-Baghdad 11877 2 0.021 0.057 0.429 0.027 0.466 Iran 9443 0 0.015 0.027 0.019 0.018 0.921 raq-Baghdad 11878 2 0.181 0.017 0.11 0.01 0.682 Iran 9444 0 0.01 0.056 0.018 0.026 0.891 raq-Baghdad 11879 0 0.024 0.213 0.027 0.022 0.715 Iran 9445 1 0.01 0.015 0.016 0.04 0.92 raq-Baghdad 11880 3 0.082 0.028 0.224 0.079 0.586 Iran 9446 2 0.012 0.028 0.012 0.02 0.928 raq-Baghdad 11881 2 0.19 0.009 0.179 0.037 0.584 Iran 9447 22 0.014 0.013 0.017 0.02 0.937 raq-Baghdad 11882 0 0.027 0.07 0.137 0.033 0.733 Iran 9448 0 0.01 0.009 0.019 0.037 0.925 raq-Baghdad 11883 2 0.123 0.018 0.28 0.049 0.53 Iran 9449 0 0.008 0.023 0.013 0.122 0.834 raq-Baghdad 11884 17 0.058 0.027 0.164 0.048 0.704 Iran 9450 0 0.01 0.011 0.014 0.016 0.949 raq-Baghdad 11885 0 0.009 0.282 0.294 0.012 0.404 Iran 9451 2 0.007 0.019 0.008 0.019 0.947 raq-Baghdad 11886 2 0.032 0.049 0.191 0.066 0.661 Iran 9452 0 0.014 0.011 0.01 0.013 0.952 raq-Baghdad 11887 16 0.051 0.069 0.14 0.016 0.724 Iran 9453 2 0.007 0.014 0.017 0.01 0.953 ran 9419 22 0.018 0.031 0.036 0.019 0.896 Iran 9454 0 0.006 0.012 0.007 0.013 0.962 ran 9420 17 0.053 0.049 0.175 0.088 0.636 Iran 9455 1 0.025 0.037 0.049 0.013 0.875 ran 9421 20 0.018 0.011 0.1 0.07 0.801 Iran 9456 4 0.006 0.015 0.009 0.01 0.96 ran 9422 18 0.017 0.012 0.079 0.07 0.822 Iran 9457 2 0.01 0.022 0.012 0.012 0.945 ran 9424 25 0.011 0.022 0.019 0.021 0.928 Iran 9458 0 0.005 0.006 0.007 0.017 0.965 ran 9425 4 0.014 0.038 0.134 0.039 0.774 Iran 9459 2 0.01 0.018 0.018 0.012 0.942 ran 9426 6 0.023 0.024 0.032 0.205 0.717 Iran 9460 0 0.012 0.031 0.026 0.065 0.866 ran 9427 3 0.014 0.157 0.029 0.031 0.769 Iran 9461 1 0.036 0.011 0.037 0.018 0.898 ran 9428 2 0.025 0.073 0.303 0.11 0.489 Iran 9462 0 0.013 0.009 0.011 0.024 0.942 ran 9429 0 0.024 0.147 0.067 0.082 0.68 Iran 9463 0 0.007 0.015 0.009 0.025 0.944 ran 9430 10 0.043 0.015 0.398 0.025 0.52 Iran 9464 0 0.012 0.037 0.013 0.051 0.886 ran 9431 0 0.014 0.035 0.052 0.027 0.872 Iran 9465 1 0.012 0.01 0.02 0.013 0.945 ran 9432 1 0.01 0.182 0.024 0.029 0.754 Iran 9466 0 0.007 0.013 0.008 0.031 0.941 ran 9433 1 0.073 0.023 0.085 0.12 0.698 Iran 9468 1 0.007 0.026 0.01 0.039 0.918 ran 9434 0 0.022 0.013 0.044 0.011 0.91 Iran 9469 0 0.017 0.011 0.017 0.079 0.875 ran 9435 2 0.012 0.027 0.02 0.028 0.913 Iran 9470 1 0.008 0.017 0.014 0.059 0.901 ran 9436 18 0.014 0.017 0.019 0.025 0.925 Iran 9471 0 0.04 0.015 0.048 0.05 0.847 ran 9437 1 0.011 0.015 0.018 0.024 0.932 Iran 9472 0 0.008 0.102 0.014 0.076 0.8 ran 9438 1 0.009 0.026 0.019 0.06 0.886 Iran 9473 0 0.02 0.011 0.012 0.018 0.94 ran 9439 0 0.008 0.007 0.009 0.015 0.96 Iran 9474 0 0.045 0.028 0.036 0.053 0.839
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Iran 9475 0 0.014 0.015 0.018 0.059 0.894 Iran 9510 2 0.009 0.014 0.011 0.025 0.94
Iran 9476 2 0.038 0.017 0.03 0.016 0.9 Iran 9511 0 0.011 0.032 0.024 0.049 0.884
Iran 9477 1 0.019 0.054 0.023 0.01 0.894 Iran 9512 1 0.007 0.008 0.011 0.021 0.953
Iran 9478 0 0.018 0.015 0.024 0.049 0.893 Iran 9513 2 0.013 0.016 0.02 0.024 0.927
Iran 9479 1 0.016 0.009 0.018 0.007 0.95 Iran 9514 2 0.027 0.023 0.062 0.025 0.864
Iran 9480 1 0.007 0.021 0.016 0.012 0.945 Iran 9515 2 0.005 0.015 0.007 0.014 0.959
Iran 9481 1 0.017 0.049 0.007 0.091 0.836 Iran 9516 5 0.009 0.012 0.015 0.026 0.938
Iran 9482 1 0.01 0.013 0.007 0.022 0.948 Iran 9517 0 0.01 0.01 0.01 0.02 0.95
Iran 9483 2 0.029 0.014 0.1 0.172 0.685 Iran 9518 1 0.007 0.026 0.009 0.011 0.947
Iran 9484 2 0.029 0.012 0.125 0.013 0.822 Iran 9519 0 0.01 0.012 0.017 0.03 0.932
Iran 9485 0 0.012 0.01 0.018 0.069 0.891 Iran 9520 1 0.006 0.009 0.008 0.01 0.966
Iran 9486 1 0.008 0.008 0.009 0.015 0.959 Iran 9521 4 0.011 0.012 0.009 0.058 0.911
Iran 9487 1 0.018 0.013 0.026 0.025 0.918 Iran 9522 7 0.006 0.009 0.011 0.01 0.965
Iran 9488 1 0.022 0.172 0.048 0.011 0.748 Iran 9523 0 0.027 0.016 0.017 0.014 0.925
Iran 9489 0 0.04 0.017 0.046 0.03 0.867 Iran 9524 0 0.006 0.009 0.009 0.023 0.953
Iran 9490 0 0.026 0.007 0.014 0.039 0.915 Iran 9526 2 0.005 0.007 0.006 0.016 0.966
Iran 9491 0 0.008 0.035 0.013 0.02 0.924 Iran 9527 1 0.009 0.046 0.015 0.026 0.904
Iran 9492 2 0.017 0.026 0.028 0.011 0.918 Iran 9528 3 0.01 0.016 0.013 0.069 0.893
Iran 9493 1 0.016 0.014 0.014 0.032 0.924 Iran 9529 1 0.012 0.017 0.016 0.009 0.945
Iran 9494 1 0.008 0.011 0.011 0.018 0.952 Iran 9530 4 0.008 0.007 0.017 0.016 0.952
Iran 9495 0 0.012 0.014 0.013 0.013 0.948 Iran 9531 2 0.01 0.048 0.017 0.028 0.897
Iran 9497 1 0.008 0.013 0.011 0.043 0.926 Iran 9532 16 0.192 0.211 0.184 0.011 0.402
Iran 9498 0 0.009 0.011 0.01 0.023 0.947 Dubai 10104 0 0.228 0.013 0.22 0.025 0.514
Iran 9499 2 0.013 0.007 0.016 0.042 0.922 Dubai 10105 2 0.069 0.113 0.169 0.022 0.627
Iran 9500 0 0.01 0.012 0.01 0.014 0.954 Dubai 10106 0 0.051 0.169 0.08 0.05 0.65
Iran 9501 1 0.023 0.014 0.016 0.01 0.938 Dubai 10107 0 0.055 0.037 0.059 0.154 0.695
Iran 9502 4 0.011 0.016 0.016 0.007 0.95 Dubai 10108 2 0.076 0.145 0.295 0.074 0.41
Iran 9503 2 0.107 0.016 0.046 0.022 0.809 Dubai 10109 1 0.034 0.083 0.048 0.332 0.503
Iran 9504 1 0.009 0.008 0.01 0.01 0.964 Dubai 10110 2 0.084 0.095 0.299 0.027 0.495
Iran 9505 2 0.033 0.013 0.026 0.01 0.918 Dubai 10111 2 0.082 0.014 0.089 0.015 0.8
Iran 9506 6 0.052 0.05 0.024 0.035 0.839 Dubai 10112 0 0.035 0.11 0.098 0.043 0.715
Iran 9507 0 0.083 0.015 0.042 0.036 0.824 Dubai 10120 0 0.032 0.028 0.063 0.193 0.685
Iran 9508 2 0.01 0.008 0.009 0.012 0.961 Kenya-Nairobi 9833 2 0.771 0.027 0.052 0.022 0.127
Iran 9509 2 0.016 0.012 0.013 0.056 0.903 Kenya-Nairobi 9834 0 0.186 0.038 0.415 0.29 0.071
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kenya- Nairobi 9835 0 0.016 0.069 0.818 0.022 0.076 Kenya-Pate 2000 0 0.04 0.039 0.047 0.306 0.568
Kenya- Nairobi 9836 2 0.61 0.182 0.133 0.051 0.023 Kenya-Pate 2001 0 0.076 0.067 0.015 0.098 0.744
Kenya- Nairobi 9837 3 0.738 0.178 0.043 0.022 0.019 Kenya-Pate 2002 0 0.084 0.059 0.016 0.087 0.754
Kenya- Nairobi 9838 4 0.532 0.079 0.325 0.019 0.045 Kenya-Pate 2003 0 0.219 0.013 0.036 0.061 0.672
Kenya- Nairobi 9839 1 0.76 0.035 0.068 0.039 0.097 Kenya-Pate 2004 1 0.029 0.201 0.26 0.115 0.395
Kenya- Nairobi 9840 4 0.757 0.072 0.043 0.022 0.105 Kenya-Pate 2006 2 0.227 0.015 0.051 0.408 0.3
Kenya- Nairobi 9841 4 0.757 0.058 0.033 0.048 0.104 Kenya-Pate 2007 3 0.14 0.011 0.201 0.319 0.329
Kenya- Nairobi 9842 2 0.532 0.039 0.309 0.057 0.064 Kenya-Pate 2009 0 0.087 0.05 0.147 0.122 0.594
Kenya- Nairobi 9843 6 0.568 0.197 0.112 0.037 0.085 Kenya-Pate 2011 0 0.049 0.043 0.132 0.324 0.453
Kenya- Nairobi 9844 4 0.639 0.201 0.058 0.045 0.058 Kenya-Lamu 1848 14 0.07 0.028 0.292 0.389 0.222
Kenya- Nairobi 9845 2 0.737 0.147 0.062 0.022 0.033 Kenya-Lamu 2014 4 0.112 0.016 0.048 0.186 0.639
Kenya- Nairobi 9846 1 0.612 0.054 0.076 0.014 0.243 Kenya-Lamu 2015 0 0.264 0.224 0.023 0.118 0.371
Kenya- Nairobi 9847 4 0.665 0.103 0.047 0.092 0.093 Kenya-Lamu 2016 0 0.019 0.22 0.034 0.151 0.576
Kenya-Nairobi 9848 4 0.679 0.049 0.167 0.042 0.062 Kenya-Lamu 2018 0 0.484 0.056 0.013 0.073 0.373
Kenya- Nairobi 9849 2 0.478 0.148 0.089 0.255 0.03 Kenya-Lamu 2019 0 0.156 0.047 0.454 0.082 0.261
Kenya- Nairobi 9850 2 0.771 0.052 0.054 0.02 0.103 Kenya-Lamu 2021 1 0.198 0.061 0.095 0.282 0.364
Kenya- Nairobi 9851 2 0.321 0.26 0.156 0.072 0.19 Kenya-Lamu 2023 1 0.049 0.042 0.083 0.232 0.593
Kenya- Nairobi 9852 4 0.394 0.21 0.136 0.174 0.087 Kenya-Lamu 2024 2 0.087 0.024 0.105 0.189 0.595
Kenya- Nairobi 9853 4 0.583 0.17 0.088 0.077 0.082 Kenya-Lamu 2025 3 0.155 0.012 0.056 0.3 0.477
Kenya- Nairobi 9854 2 0.515 0.281 0.121 0.047 0.036 Kenya-Lamu 2026 1 0.138 0.022 0.208 0.091 0.542
Kenya- Nairobi 9855 2 0.523 0.103 0.071 0.153 0.151 Kenya-Lamu 2027 2 0.06 0.01 0.033 0.558 0.339
Kenya- Nairobi 9856 3 0.564 0.118 0.086 0.037 0.195 Kenya-Lamu 2029 1 0.09 0.03 0.11 0.211 0.56
Kenya- Nairobi 9857 2 0.789 0.047 0.099 0.018 0.047 Kenya-Lamu 2030 0 0.118 0.01 0.072 0.038 0.761
Kenya- Nairobi 9858 0 0.579 0.037 0.051 0.105 0.227 Kenya-Lamu 2031 0 0.067 0.025 0.041 0.23 0.636
Kenya-Nairobi 9859 1 0.761 0.045 0.061 0.109 0.024 Kenya-Lamu 2032 0 0.039 0.023 0.1 0.22 0.619
Kenya- Nairobi 9860 2 0.726 0.108 0.032 0.103 0.03 Kenya-Lamu 2033 0 0.112 0.022 0.071 0.048 0.746
Kenya- Nairobi 9861 1 0.666 0.054 0.096 0.098 0.086 Kenya-Lamu 3241 0 0.115 0.017 0.235 0.032 0.601
Kenya- Nairobi 9862 1 0.717 0.158 0.06 0.024 0.041 Kenya-Lamu 3246 0 0.3 0.192 0.049 0.081 0.378
Kenya- Nairobi 9863 1 0.379 0.18 0.132 0.271 0.039 Kenya-Lamu 3247 0 0.141 0.031 0.119 0.488 0.221
Kenya- Nairobi 9864 1 0.368 0.226 0.22 0.076 0.11 India-Udaipur 11835 7 0.023 0.368 0.021 0.12 0.469
Kenya- Nairobi 9865 2 0.859 0.021 0.042 0.055 0.023 India-Udaipur 11836 3 0.163 0.076 0.088 0.187 0.487
Kenya- Nairobi 9866 2 0.623 0.216 0.031 0.054 0.075 India-Udaipur 11837 1 0.014 0.099 0.051 0.408 0.429
Kenya- Nairobi 9867 0 0.752 0.028 0.058 0.11 0.052 India-Agra 11823 2 0.029 0.258 0.189 0.243 0.281
Kenya- Nairobi 9868 5 0.585 0.312 0.03 0.025 0.048 India-Agra 11824 2 0.036 0.023 0.371 0.038 0.533
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
India-Agra 11825 2 0.012 0.031 0.022 0.356 0.58 India-
India-Agra 11826 6 0.015 0.023 0.058 0.569 0.335 Hyderbad 11815 2 0.023 0.273 0.629 0.027 0.048
India-Agra 11827 25 0.046 0.105 0.111 0.104 0.634 India-
India-Agra 11828 2 0.036 0.042 0.72 0.07 0.132 Hyderbad 11816 4 0.027 0.032 0.054 0.226 0.661
India-Agra 11829 4 0.02 0.06 0.041 0.281 0.598 India-
India-Agra 11830 8 0.042 0.024 0.093 0.193 0.648 Hyderbad 11817 2 0.017 0.493 0.264 0.044 0.182
India-Agra 11831 2 0.015 0.029 0.027 0.205 0.724 India-
India-Agra 11832 2 0.017 0.096 0.024 0.175 0.687 Hyderbad 11818 1 0.534 0.372 0.04 0.012 0.042
India-Agra 11833 20 0.037 0.364 0.196 0.126 0.276 India-
India-Agra 11834 2 0.019 0.023 0.051 0.563 0.344 Hyderbad 11819 6 0.031 0.033 0.086 0.233 0.617
India- India-
Hyderbad 11802 14 0.018 0.609 0.244 0.048 0.081 Hyderbad 11820 6 0.01 0.379 0.044 0.074 0.494
India- India-
Hyderbad 11803 7 0.018 0.207 0.074 0.045 0.657 Hyderbad 11821 17 0.028 0.572 0.228 0.033 0.139
India- India-
Hyderbad 11804 4 0.01 0.385 0.033 0.242 0.33 Hyderbad 11822 2 0.042 0.235 0.167 0.076 0.48
India- India-Andhra 10159 1 0.069 0.286 0.097 0.065 0.484
Hyderbad 11805 11 0.023 0.284 0.308 0.035 0.351 India-Andhra 10160 1 0.017 0.605 0.023 0.307 0.048
India- India-Andhra 10161 2 0.105 0.382 0.086 0.054 0.373
Hyderbad 11807 13 0.141 0.369 0.175 0.201 0.113 India-Andhra 10162 5 0.062 0.599 0.041 0.04 0.258
India- India-Andhra 10163 0 0.039 0.452 0.043 0.041 0.424
Hyderbad 11808 10 0.158 0.156 0.284 0.261 0.141 India-Andhra 10164 2 0.396 0.382 0.066 0.043 0.114
India- India-Andhra 10165 1 0.079 0.752 0.095 0.02 0.054
Hyderbad 11809 4 0.201 0.224 0.085 0.1 0.39 India-Andhra 10166 2 0.038 0.477 0.112 0.031 0.342
India- India-Andhra 10167 0 0.025 0.717 0.033 0.087 0.138
Hyderbad 11810 0 0.033 0.041 0.054 0.434 0.438 India-Andhra 10168 1 0.141 0.632 0.133 0.048 0.045
India- India-Andhra 10169 7 0.061 0.512 0.111 0.065 0.251
Hyderbad 11811 0 0.173 0.064 0.458 0.179 0.126 India-Andhra 10170 6 0.02 0.49 0.349 0.071 0.069
India- India-Andhra 10171 1 0.393 0.389 0.069 0.041 0.107
Hyderbad 11812 0 0.021 0.253 0.143 0.137 0.447 India-Andhra 10172 2 0.046 0.572 0.098 0.038 0.247
India- India-Andhra 10173 2 0.075 0.647 0.085 0.018 0.175
Hyderbad 11813 2 0.068 0.5 0.333 0.034 0.064 India-Andhra 10174 3 0.043 0.4 0.104 0.367 0.086
India- India-Andhra 10175 2 0.061 0.296 0.234 0.358 0.051
Hyderbad 11814 2 0.021 0.272 0.164 0.016 0.527 India-Andhra 10176 2 0.065 0.303 0.29 0.214 0.127
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
India-Andhra 10177 0 0.327 0.448 0.017 0.122 0.086 Sri Lanka 8802 2 0.359 0.129 0.126 0.316 0.07
India-Andhra 10178 2 0.061 0.66 0.075 0.05 0.155 Sri Lanka 8803 4 0.151 0.403 0.128 0.277 0.041
India-Andhra 10179 5 0.036 0.547 0.024 0.042 0.351 Thailand 11688 6 0.03 0.94 0.011 0.012 0.007
India-Andhra 10180 12 0.081 0.287 0.081 0.216 0.335 Thailand 11689 13 0.009 0.942 0.008 0.032 0.009
India-Andhra 10181 4 0.058 0.537 0.056 0.103 0.246 Thailand 11691 20 0.026 0.921 0.016 0.023 0.013
India-Kolkata 10113 0 0.019 0.019 0.062 0.573 0.326 Thailand 11698 17 0.006 0.972 0.009 0.007 0.006
India-Kolkata 10114 1 0.038 0.588 0.115 0.088 0.171 Thailand 11702 10 0.006 0.95 0.006 0.03 0.008
India-Kolkata 10115 1 0.021 0.222 0.504 0.191 0.062 Thailand 11703 12 0.007 0.958 0.009 0.018 0.007
India-Kolkata 10116 1 0.008 0.538 0.022 0.054 0.377 Thailand 11705 21 0.014 0.873 0.034 0.026 0.053
India-Kolkata 10117 2 0.029 0.415 0.407 0.06 0.089 Thailand 11707 3 0.005 0.96 0.007 0.018 0.01
India-Kolkata 10118 0 0.137 0.423 0.253 0.11 0.076 Thailand 11708 22 0.009 0.95 0.009 0.022 0.01
India-Kolkata 10119 2 0.175 0.202 0.231 0.076 0.316 Thailand 11709 12 0.006 0.958 0.008 0.013 0.014
Sri Lanka 8780 2 0.173 0.057 0.098 0.563 0.11 Thailand 11710 8 0.016 0.921 0.019 0.029 0.015
Sri Lanka 8781 0 0.256 0.312 0.08 0.296 0.056 Thailand 11711 7 0.011 0.951 0.01 0.016 0.012
Sri Lanka 8782 0 0.093 0.207 0.431 0.202 0.067 Thailand 11714 5 0.015 0.944 0.012 0.012 0.017
Sri Lanka 8783 0 0.082 0.224 0.64 0.022 0.033 Thailand 11715 16 0.016 0.8 0.015 0.02 0.148
Sri Lanka 8784 0 0.482 0.348 0.074 0.074 0.023 Thailand 11717 15 0.005 0.951 0.008 0.014 0.022
Sri Lanka 8785 11 0.332 0.321 0.03 0.133 0.183 Thailand 11718 0 0.004 0.973 0.004 0.01 0.008
Sri Lanka 8786 0 0.121 0.134 0.094 0.449 0.202 Thailand 11720 3 0.004 0.98 0.004 0.006 0.006
Sri Lanka 8787 0 0.529 0.18 0.082 0.099 0.11 Vietnam 8844 4 0.023 0.93 0.009 0.02 0.018
Sri Lanka 8788 4 0.078 0.234 0.534 0.065 0.088 Vietnam 8845 1 0.025 0.788 0.053 0.029 0.104
Sri Lanka 8789 2 0.164 0.333 0.384 0.085 0.034 Vietnam 8846 0 0.021 0.92 0.033 0.013 0.014
Sri Lanka 8790 1 0.279 0.568 0.095 0.012 0.047 Vietnam 8847 9 0.01 0.957 0.009 0.018 0.006
Sri Lanka 8791 0 0.159 0.316 0.429 0.058 0.038 Vietnam 8848 6 0.009 0.945 0.014 0.02 0.011
Sri Lanka 8792 0 0.029 0.054 0.461 0.193 0.264 Vietnam 8849 2 0.026 0.87 0.048 0.036 0.02
Sri Lanka 8793 1 0.146 0.083 0.333 0.101 0.337 Vietnam 8850 0 0.085 0.795 0.042 0.038 0.041
Sri Lanka 8794 1 0.117 0.075 0.257 0.211 0.339 Vietnam 8851 0 0.032 0.774 0.094 0.013 0.087
Sri Lanka 8795 1 0.399 0.138 0.162 0.207 0.094 Vietnam 8852 13 0.046 0.813 0.06 0.063 0.019
Sri Lanka 8796 3 0.049 0.189 0.198 0.384 0.18 Vietnam 8853 1 0.13 0.713 0.102 0.036 0.019
Sri Lanka 8797 0 0.293 0.437 0.069 0.035 0.165 Vietnam 8854 5 0.02 0.832 0.04 0.056 0.051
Sri Lanka 8798 0 0.055 0.077 0.51 0.303 0.054 Vietnam 8855 0 0.277 0.639 0.06 0.015 0.009
Sri Lanka 8799 1 0.364 0.205 0.132 0.089 0.21 Vietnam 8856 0 0.03 0.857 0.038 0.034 0.041
Sri Lanka 8800 0 0.55 0.254 0.08 0.048 0.068 Vietnam 8857 2 0.058 0.664 0.228 0.036 0.014
Sri Lanka 8801 4 0.306 0.149 0.254 0.165 0.125 Vietnam 8858 0 0.098 0.625 0.25 0.01 0.018
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Vietnam 8859 6 0.049 0.774 0.093 0.059 0.025 Japan-Oita 11967 4 0.04 0.679 0.054 0.195 0.032
Vietnam 8860 0 0.017 0.701 0.049 0.146 0.087 Japan-Oita 11968 5 0.319 0.298 0.031 0.329 0.022
Vietnam 8861 0 0.026 0.66 0.133 0.136 0.045 Japan-Oita 11969 5 0.135 0.292 0.108 0.447 0.018
Vietnam 8862 0 0.087 0.507 0.112 0.038 0.257 Japan-Oita 11970 16 0.031 0.847 0.077 0.029 0.016
Vietnam 8863 0 0.2 0.61 0.146 0.017 0.027 Japan-Oita 11971 8 0.032 0.538 0.156 0.122 0.152
Taiwan 8681 3 0.593 0.043 0.015 0.333 0.015 Japan-Oita 11972 3 0.067 0.468 0.252 0.182 0.032
Taiwan 8682 0 0.204 0.461 0.057 0.171 0.107 Japan-Oita 11973 2 0.398 0.043 0.014 0.53 0.014
Taiwan 8683 2 0.06 0.125 0.409 0.276 0.13 Japan-Oita 11974 20 0.015 0.45 0.023 0.485 0.027
Taiwan 8684 2 0.6 0.06 0.019 0.281 0.039 Japan-Oita 11975 22 0.275 0.545 0.052 0.116 0.013
Taiwan 8685 2 0.026 0.355 0.022 0.562 0.036 Japan-Oita 11976 16 0.033 0.602 0.015 0.316 0.034
Taiwan 8686 6 0.158 0.096 0.068 0.572 0.106 Japan-Oita 11977 4 0.014 0.629 0.01 0.295 0.052
Taiwan 8687 6 0.019 0.585 0.098 0.262 0.035 Japan-Oita 11979 12 0.147 0.667 0.024 0.113 0.049
Taiwan 8688 21 0.098 0.335 0.047 0.382 0.138 Japan-Oita 11980 21 0.013 0.694 0.03 0.148 0.115
Taiwan 8689 5 0.027 0.056 0.034 0.537 0.346 Japan-Oita 11981 18 0.012 0.164 0.012 0.798 0.014
Taiwan 8690 0 0.016 0.215 0.017 0.693 0.059 Japan-Oita 11982 4 0.025 0.427 0.018 0.472 0.058
Taiwan 8691 14 0.068 0.254 0.036 0.56 0.081 Japan-Oita 11985 11 0.033 0.255 0.043 0.639 0.03
Taiwan 8692 3 0.127 0.5 0.063 0.215 0.094 Japan-Oita 11986 6 0.364 0.431 0.036 0.146 0.023
Taiwan 8693 0 0.174 0.196 0.033 0.489 0.108 Japan-
Taiwan 8694 0 0.28 0.228 0.086 0.299 0.107 Kanazawa 11929 6 0.933 0.008 0.015 0.02 0.024
Taiwan 8695 0 0.089 0.297 0.091 0.509 0.014 Japan-
Taiwan 8696 8 0.968 0.005 0.013 0.008 0.006 Kanazawa 11931 20 0.033 0.12 0.014 0.794 0.038
Taiwan 8697 0 0.723 0.034 0.019 0.193 0.031 Japan-
Taiwan 8698 4 0.948 0.008 0.014 0.019 0.011 Kanazawa 11932 6 0.123 0.124 0.028 0.701 0.024
Taiwan 8699 6 0.057 0.239 0.077 0.428 0.199 Japan-
Taiwan 8700 1 0.337 0.2 0.048 0.38 0.036 Kanazawa 11933 14 0.132 0.042 0.048 0.767 0.011
Taiwan 8701 2 0.099 0.191 0.015 0.67 0.026 Japan-
Taiwan 8702 1 0.33 0.101 0.036 0.509 0.023 Kanazawa 11934 3 0.145 0.042 0.023 0.783 0.007
Taiwan 8703 1 0.8 0.083 0.042 0.041 0.034 Japan-
Taiwan 8704 0 0.016 0.162 0.154 0.654 0.013 Kanazawa 11936 8 0.065 0.419 0.029 0.459 0.027
Taiwan 8705 1 0.025 0.26 0.043 0.631 0.041 Japan-
Taiwan 8706 0 0.111 0.13 0.199 0.288 0.273 Kanazawa 11937 27 0.035 0.033 0.019 0.889 0.025
Taiwan 8707 4 0.031 0.177 0.088 0.522 0.182 Japan-
Taiwan 8708 0 0.93 0.027 0.014 0.013 0.017 Kanazawa 11939 20 0.022 0.321 0.011 0.637 0.009
Taiwan 8709 2 0.021 0.212 0.022 0.72 0.025 Japan- 11940 12 0.018 0.116 0.014 0.838 0.014
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kanazawa Sapporo
Japan- Japan-
Kanazawa 11941 6 0.029 0.334 0.016 0.607 0.014 Sapporo 11913 16 0.046 0.345 0.129 0.455 0.025
Japan- Japan-
Kanazawa 11942 9 0.011 0.04 0.009 0.93 0.01 Sapporo 11914 4 0.033 0.315 0.194 0.412 0.046
Japan- Japan-
Kanazawa 11943 17 0.018 0.467 0.02 0.45 0.045 Sapporo 11915 7 0.012 0.819 0.01 0.148 0.011
Japan- Japan-
Kanazawa 11944 7 0.508 0.119 0.256 0.049 0.069 Sapporo 11916 7 0.926 0.021 0.034 0.007 0.012
Japan- Japan-
Kanazawa 11945 18 0.048 0.132 0.025 0.781 0.014 Sapporo 11917 4 0.905 0.011 0.017 0.018 0.049
Japan- Japan-
Kanazawa 11946 16 0.006 0.029 0.009 0.949 0.006 Sapporo 11918 13 0.087 0.207 0.045 0.613 0.048
Japan-Ohmiya 11947 4 0.085 0.12 0.106 0.672 0.017 Japan-
Japan-Ohmiya 11948 17 0.009 0.031 0.013 0.924 0.024 Sapporo 11921 5 0.012 0.378 0.038 0.526 0.046
Japan-Ohmiya 11951 22 0.06 0.049 0.064 0.731 0.096 Japan-
Japan-Ohmiya 11953 2 0.011 0.267 0.015 0.693 0.014 Sapporo 11922 6 0.016 0.058 0.015 0.507 0.404
Japan-Ohmiya 11954 2 0.064 0.066 0.029 0.814 0.026 Japan-
Japan-Ohmiya 11955 5 0.237 0.019 0.014 0.707 0.022 Sapporo 11923 7 0.005 0.408 0.007 0.57 0.009
Japan-Ohmiya 11956 2 0.009 0.722 0.025 0.233 0.011 Japan-
Japan-Ohmiya 11957 3 0.063 0.077 0.086 0.755 0.019 Sapporo 11924 6 0.58 0.192 0.056 0.158 0.014
Japan-Ohmiya 11959 4 0.02 0.196 0.016 0.757 0.011 Japan-
Japan-Ohmiya 11960 3 0.014 0.551 0.011 0.413 0.011 Sapporo 11925 9 0.011 0.9 0.017 0.04 0.032
Japan-Ohmiya 11961 3 0.033 0.17 0.02 0.76 0.017 Japan-
Japan-Ohmiya 11962 4 0.328 0.13 0.047 0.469 0.027 Sapporo 11926 11 0.083 0.032 0.318 0.513 0.054
Japan-Ohmiya 11963 3 0.026 0.155 0.03 0.699 0.091 China-Henan 8869 2 0.007 0.014 0.022 0.851 0.106
Japan-Ohmiya 11964 4 0.053 0.025 0.02 0.879 0.024 China-Henan 8870 0 0.01 0.016 0.017 0.932 0.025
Japan-Ohmiya 11965 4 0.046 0.141 0.16 0.557 0.096 China-Henan 8871 0 0.013 0.012 0.021 0.926 0.028
Japan-Ohmiya 11966 5 0.089 0.179 0.077 0.565 0.09 China-Henan 8872 1 0.021 0.027 0.046 0.885 0.021
Japan- China-Henan 8873 1 0.006 0.011 0.013 0.925 0.045
Sapporo 11907 7 0.059 0.118 0.026 0.675 0.122 China-Henan 8874 8 0.008 0.069 0.016 0.793 0.114
Japan- China-Henan 8875 1 0.008 0.008 0.012 0.953 0.02
Sapporo 11909 9 0.955 0.011 0.01 0.011 0.012 China-Henan 8876 0 0.007 0.012 0.011 0.953 0.018
Japan- 11911 17 0.304 0.053 0.029 0.593 0.02 China-Henan 8877 0 0.062 0.01 0.019 0.882 0.027
Table 20 - Population clustering of each random bred Table 20 - Population clustering of each random bred individual in the database by SNPs at K = 5 individual in the database by SNPs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
China-Henan 8878 2 0.012 0.01 0.026 0.904 0.049 South Korea 7686 2 0.03 0.008 0.037 0.888 0.036
China-Henan 8879 2 0.015 0.009 0.016 0.944 0.016 South Korea 7687 4 0.121 0.133 0.049 0.676 0.021
China-Henan 8880 0 0.078 0.009 0.03 0.857 0.026 South Korea 7688 13 0.326 0.024 0.014 0.622 0.015
China-Henan 8881 2 0.01 0.013 0.018 0.912 0.047 South Korea 7689 0 0.01 0.008 0.01 0.877 0.095
China-Henan 8882 2 0.015 0.012 0.02 0.913 0.04 South Korea 7690 0 0.061 0.027 0.115 0.757 0.04
China-Henan 8883 0 0.013 0.014 0.01 0.853 0.11 South Korea 7691 2 0.01 0.179 0.013 0.786 0.013
China-Henan 8884 0 0.008 0.007 0.009 0.949 0.027 South Korea 7692 0 0.057 0.026 0.073 0.767 0.077
China-Henan 8885 0 0.024 0.012 0.048 0.773 0.144 South Korea 7693 0 0.021 0.049 0.03 0.86 0.04
China-Henan 8886 0 0.007 0.009 0.013 0.913 0.059 South Korea 7694 1 0.007 0.056 0.016 0.905 0.016
China-Henan 8887 1 0.009 0.042 0.021 0.886 0.043 South Korea 7695 9 0.081 0.009 0.121 0.741 0.049
China-Henan 8888 1 0.01 0.007 0.009 0.963 0.011 South Korea 7696 2 0.015 0.01 0.018 0.939 0.018
South Korea 2769 4 0.018 0.018 0.061 0.812 0.091 South Korea 7697 2 0.061 0.014 0.045 0.832 0.048
South Korea 2772 12 0.01 0.01 0.008 0.961 0.011 South Korea 7698 2 0.023 0.363 0.111 0.489 0.013
South Korea 2775 8 0.015 0.075 0.025 0.828 0.057 South Korea 7699 0 0.043 0.031 0.065 0.846 0.014
South Korea 2776 25 0.008 0.038 0.011 0.908 0.035 South Korea 7700 6 0.012 0.035 0.018 0.916 0.019
South Korea 2779 0 0.03 0.046 0.023 0.849 0.052
South Korea 2784 2 0.018 0.016 0.056 0.817 0.094
South Korea 2785 1 0.011 0.033 0.018 0.909 0.029
South Korea 2786 2 0.011 0.042 0.021 0.918 0.009
South Korea 7671 1 0.121 0.014 0.064 0.775 0.025
South Korea 7672 0 0.009 0.102 0.019 0.843 0.026
South Korea 7673 0 0.014 0.015 0.047 0.892 0.033
South Korea 7674 1 0.12 0.015 0.114 0.581 0.171
South Korea 7675 2 0.009 0.021 0.011 0.943 0.016
South Korea 7676 2 0.154 0.028 0.05 0.753 0.014
South Korea 7677 14 0.835 0.041 0.054 0.054 0.016
South Korea 7678 0 0.024 0.018 0.014 0.928 0.016
South Korea 7679 2 0.015 0.023 0.036 0.905 0.021
South Korea 7680 8 0.168 0.012 0.045 0.744 0.031
South Korea 7681 2 0.017 0.063 0.018 0.888 0.014
South Korea 7682 0 0.008 0.051 0.01 0.921 0.01
South Korea 7683 0 0.008 0.012 0.008 0.952 0.021
South Korea 7684 1 0.561 0.014 0.025 0.291 0.11
South Korea 7685 6 0.03 0.134 0.098 0.628 0.109
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
USA-NY 2547 2 0.006 0.013 0.111 0.821 0.049 Brazil 7966 5 0.005 0.015 0.011 0.96 0.009
USA-NY 2559 13 0.004 0.006 0.176 0.803 0.011 Brazil 7968 23 0.009 0.008 0.018 0.953 0.011
USA-NY 2568 2 0.017 0.004 0.01 0.963 0.006 Brazil 7969 2 0.006 0.005 0.01 0.971 0.009
USA-NY 2569 21 0.022 0.015 0.028 0.923 0.013 Brazil 7970 2 0.005 0.005 0.016 0.96 0.014
USA-NY 2572 5 0.012 0.007 0.016 0.863 0.102 Brazil 7971 2 0.013 0.006 0.007 0.968 0.007
USA-NY 2578 5 0.005 0.008 0.01 0.962 0.016 Brazil 7972 2 0.007 0.009 0.011 0.968 0.006
USA-NY 2590 5 0.005 0.003 0.037 0.935 0.019 Brazil 7973 2 0.015 0.006 0.015 0.958 0.007
USA-NY 2591 7 0.031 0.01 0.017 0.929 0.012 Brazil 7974 2 0.009 0.008 0.014 0.955 0.014
USA-NY 2597 15 0.011 0.014 0.018 0.865 0.092 Brazil 7975 13 0.019 0.005 0.017 0.943 0.017
USA-MS 9971 5 0.011 0.011 0.018 0.888 0.072 Brazil 7976 2 0.008 0.004 0.007 0.976 0.005
USA-MS 9972 0 0.013 0.019 0.021 0.857 0.089 Brazil 7977 7 0.009 0.004 0.016 0.967 0.005
USA-MS 9974 2 0.011 0.01 0.023 0.908 0.048 Brazil 7978 2 0.007 0.006 0.011 0.962 0.015
USA-MS 9977 10 0.015 0.012 0.017 0.936 0.02 Brazil 7979 5 0.022 0.007 0.014 0.943 0.014
USA-MS 9980 7 0.007 0.017 0.043 0.922 0.012 Brazil 7980 2 0.026 0.025 0.262 0.675 0.013
USA-MS 9983 7 0.006 0.008 0.011 0.951 0.024 Brazil 7981 5 0.145 0.009 0.02 0.791 0.036
USA-MS 9985 5 0.133 0.004 0.051 0.795 0.017 Brazil 7982 42 0.038 0.014 0.055 0.832 0.062
USA-MS 9987 10 0.01 0.015 0.025 0.92 0.031 Brazil 7983 15 0.007 0.009 0.03 0.768 0.186
USA-MS 9989 2 0.05 0.009 0.042 0.875 0.024 Brazil 7984 50 0.136 0.024 0.137 0.6 0.103
USA-MS 9992 7 0.016 0.009 0.136 0.754 0.085 Brazil 7985 21 0.006 0.006 0.012 0.964 0.011
USA-HI 5366 10 0.161 0.005 0.057 0.681 0.097 Brazil 7986 10 0.033 0.01 0.032 0.905 0.021
USA-HI 5367 7 0.017 0.016 0.092 0.8 0.074 Brazil 7987 5 0.009 0.006 0.017 0.886 0.081
USA-HI 5371 5 0.064 0.024 0.319 0.448 0.144 Brazil 7988 2 0.015 0.027 0.049 0.843 0.066
USA-HI 5372 7 0.02 0.011 0.047 0.762 0.161 Brazil 7989 5 0.02 0.011 0.018 0.893 0.057
USA-HI 5379 2 0.051 0.021 0.03 0.878 0.019 Brazil 7990 5 0.005 0.004 0.007 0.973 0.012
USA-HI 5380 2 0.016 0.007 0.019 0.948 0.01 Finland 8077 23 0.004 0.007 0.008 0.976 0.005
USA-HI 5383 10 0.025 0.122 0.386 0.43 0.037 Finland 8084 31 0.037 0.008 0.024 0.88 0.051
USA-HI 5384 18 0.005 0.007 0.175 0.805 0.008 Finland 8086 13 0.005 0.007 0.028 0.954 0.006
USA-HI 5401 5 0.063 0.005 0.442 0.466 0.024 Finland 8089 26 0.016 0.017 0.02 0.914 0.033
USA-HI 5402 7 0.117 0.057 0.066 0.741 0.018 Finland 8093 18 0.004 0.005 0.373 0.612 0.005
Brazil 7961 2 0.011 0.005 0.02 0.959 0.005 Finland 8094 34 0.013 0.072 0.104 0.78 0.03
Brazil 7962 2 0.004 0.003 0.077 0.907 0.008 Finland 8096 23 0.006 0.013 0.138 0.834 0.009
Brazil 7963 23 0.008 0.006 0.014 0.791 0.181 Finland 8107 31 0.004 0.004 0.008 0.979 0.005
Brazil 7964 5 0.013 0.005 0.009 0.958 0.014 Finland 8110 28 0.013 0.021 0.238 0.606 0.123
Brazil 7965 65 0.007 0.008 0.014 0.958 0.014 Finland 8116 44 0.015 0.02 0.034 0.914 0.017
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Finland 8120 28 0.015 0.014 0.087 0.878 0.006 Italy-Milan 8062 10 0.017 0.01 0.441 0.511 0.021
Germany 8711 13 0.004 0.004 0.007 0.981 0.004 Italy-Milan 8065 10 0.02 0.007 0.576 0.384 0.013
Germany 8712 2 0.012 0.019 0.007 0.946 0.016 Italy-Milan 8066 2 0.006 0.006 0.011 0.927 0.05
Germany 8713 7 0.039 0.034 0.022 0.885 0.02 Italy-Milan 8067 2 0.006 0.016 0.37 0.555 0.053
Germany 8714 5 0.007 0.014 0.017 0.952 0.011 Italy-Milan 8068 7 0.01 0.008 0.627 0.337 0.019
Germany 8715 5 0.005 0.006 0.011 0.972 0.007 Italy-Milan 8069 2 0.021 0.024 0.251 0.529 0.175
Germany 8716 2 0.005 0.006 0.012 0.972 0.006 Italy-Milan 8071 5 0.01 0.008 0.017 0.95 0.015
Germany 8717 7 0.006 0.006 0.013 0.968 0.007 Italy-Milan 8072 7 0.084 0.054 0.135 0.698 0.03
Germany 8720 5 0.038 0.007 0.012 0.493 0.45 Italy-Milan 8073 5 0.027 0.033 0.164 0.739 0.037
Germany 8721 10 0.005 0.014 0.063 0.911 0.006 Italy-Milan 8074 5 0.026 0.004 0.015 0.603 0.352
Germany 8727 7 0.006 0.006 0.133 0.84 0.015 Italy-Rome 8586 2 0.08 0.021 0.294 0.583 0.022
Germany 8728 10 0.005 0.004 0.006 0.977 0.007 Italy-Rome 8589 7 0.079 0.007 0.154 0.742 0.018
Germany 8729 7 0.003 0.003 0.011 0.98 0.004 Italy-Rome 8592 7 0.013 0.119 0.219 0.628 0.021
Germany 8730 21 0.011 0.004 0.132 0.843 0.01 Italy-Rome 8594 2 0.01 0.095 0.037 0.836 0.021
Germany 8731 13 0.008 0.006 0.022 0.957 0.008 Italy-Rome 8595 5 0.031 0.173 0.149 0.548 0.098
Germany 8732 7 0.006 0.004 0.012 0.961 0.016 Italy-Rome 8596 2 0.05 0.012 0.415 0.507 0.017
Germany 8733 23 0.015 0.011 0.013 0.944 0.016 Italy-Rome 8597 2 0.021 0.039 0.199 0.721 0.019
Germany 8734 7 0.004 0.002 0.011 0.978 0.004 Italy-Rome 8599 5 0.074 0.007 0.258 0.647 0.014
Germany 8735 7 0.005 0.004 0.01 0.973 0.007 Italy-Rome 8601 2 0.034 0.242 0.03 0.676 0.017
Germany 8736 5 0.015 0.116 0.022 0.836 0.011 Italy-Rome 8602 5 0.011 0.015 0.24 0.716 0.018
Germany 8737 10 0.021 0.024 0.068 0.848 0.039 Italy-Rome 8603 5 0.007 0.026 0.078 0.863 0.026
Germany 8738 10 0.009 0.145 0.023 0.814 0.01 Italy-Rome 8604 7 0.232 0.027 0.029 0.684 0.028
Germany 8739 7 0.005 0.005 0.01 0.966 0.013 Italy-Rome 8609 5 0.018 0.014 0.515 0.438 0.015
Germany 8741 7 0.005 0.003 0.007 0.978 0.006 Italy-Rome 8610 7 0.008 0.005 0.247 0.731 0.008
Germany 8742 7 0.009 0.005 0.007 0.975 0.004 Italy-Rome 8611 2 0.01 0.094 0.155 0.732 0.009
Germany 8744 7 0.163 0.026 0.1 0.672 0.039 Turkey 6477 5 0.009 0.052 0.866 0.067 0.006
Germany 8745 26 0.008 0.01 0.049 0.917 0.015 Turkey 6478 10 0.006 0.018 0.944 0.023 0.009
Germany 8746 5 0.004 0.004 0.008 0.977 0.007 Turkey 6480 7 0.014 0.01 0.779 0.129 0.069
Germany 8747 18 0.012 0.004 0.014 0.959 0.01 Turkey 6481 5 0.034 0.005 0.026 0.069 0.866
Germany 8749 7 0.004 0.005 0.006 0.98 0.004 Turkey 6482 7 0.02 0.118 0.378 0.44 0.045
Italy-Milan 8050 5 0.303 0.027 0.04 0.597 0.032 Turkey 6484 5 0.008 0.01 0.894 0.067 0.022
Italy-Milan 8057 5 0.009 0.039 0.23 0.578 0.145 Turkey 6486 5 0.007 0.031 0.766 0.156 0.04
Italy-Milan 8060 2 0.008 0.007 0.224 0.717 0.044 Turkey 6487 7 0.011 0.011 0.938 0.033 0.006
Italy-Milan 8061 5 0.04 0.055 0.521 0.298 0.085 Turkey 6488 7 0.026 0.031 0.774 0.154 0.015
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Turkey 6491 13 0.556 0.005 0.036 0.304 0.1 Turkey 6750 5 0.005 0.005 0.314 0.669 0.007
Turkey 6494 7 0.031 0.063 0.445 0.437 0.024 Turkey 6753 10 0.115 0.083 0.612 0.129 0.062
Turkey 6496 5 0.019 0.01 0.622 0.199 0.15 Turkey 6754 10 0.005 0.22 0.525 0.242 0.008
Turkey 6499 7 0.019 0.015 0.406 0.548 0.012 Turkey 6755 10 0.042 0.018 0.566 0.361 0.012
Turkey 6500 15 0.005 0.006 0.941 0.043 0.005 Turkey 6756 10 0.005 0.015 0.421 0.551 0.008
Turkey 6502 7 0.02 0.006 0.89 0.071 0.013 Turkey 6758 13 0.073 0.059 0.718 0.136 0.015
Turkey 6503 10 0.035 0.013 0.605 0.296 0.051 Turkey 6759 13 0.013 0.006 0.892 0.071 0.018
Turkey 6507 5 0.015 0.008 0.853 0.118 0.006 Turkey 6760 7 0.008 0.019 0.261 0.665 0.048
Turkey 6510 5 0.012 0.004 0.159 0.819 0.006 Cyprus 10128 2 0.041 0.009 0.875 0.061 0.014
Turkey 6512 7 0.025 0.012 0.894 0.049 0.019 Cyprus 10129 5 0.005 0.008 0.705 0.274 0.008
Turkey 6513 5 0.008 0.053 0.775 0.086 0.078 Cyprus 10130 7 0.013 0.01 0.519 0.408 0.05
Turkey 6514 5 0.378 0.009 0.009 0.02 0.584 Cyprus 10131 2 0.024 0.017 0.788 0.021 0.15
Turkey 6516 5 0.003 0.011 0.019 0.953 0.013 Cyprus 10132 2 0.01 0.019 0.888 0.059 0.024
Turkey 6519 5 0.007 0.015 0.625 0.338 0.015 Cyprus 10133 15 0.009 0.027 0.856 0.089 0.019
Turkey 6520 5 0.008 0.006 0.335 0.632 0.02 Cyprus 10134 5 0.006 0.027 0.934 0.013 0.019
Turkey 6521 7 0.049 0.029 0.747 0.161 0.013 Cyprus 10135 5 0.017 0.005 0.802 0.03 0.146
Turkey 6729 5 0.055 0.336 0.555 0.029 0.025 Cyprus 10136 5 0.027 0.091 0.486 0.372 0.024
Turkey 6730 5 0.026 0.011 0.504 0.451 0.008 Cyprus 10137 2 0.04 0.269 0.603 0.079 0.009
Turkey 6731 7 0.005 0.049 0.422 0.507 0.017 Cyprus 10138 2 0.012 0.036 0.92 0.015 0.016
Turkey 6732 7 0.062 0.166 0.354 0.256 0.162 Cyprus 10139 2 0.02 0.047 0.584 0.017 0.331
Turkey 6733 7 0.055 0.021 0.499 0.374 0.05 Cyprus 10140 0 0.006 0.027 0.882 0.07 0.014
Turkey 6734 5 0.044 0.01 0.568 0.346 0.032 Cyprus 10141 5 0.019 0.034 0.394 0.54 0.013
Turkey 6735 7 0.006 0.021 0.951 0.012 0.01 Cyprus 10142 2 0.043 0.022 0.871 0.014 0.049
Turkey 6736 2 0.006 0.017 0.881 0.087 0.009 Cyprus 10143 5 0.012 0.015 0.953 0.014 0.006
Turkey 6738 7 0.016 0.032 0.847 0.076 0.029 Cyprus 10144 7 0.008 0.006 0.931 0.039 0.016
Turkey 6739 13 0.011 0.06 0.42 0.491 0.018 Cyprus 10145 5 0.005 0.008 0.906 0.076 0.005
Turkey 6740 5 0.004 0.004 0.004 0.982 0.006 Cyprus 10146 0 0.012 0.008 0.922 0.01 0.048
Turkey 6741 7 0.041 0.006 0.011 0.021 0.921 Cyprus 10147 5 0.004 0.006 0.899 0.085 0.007
Turkey 6742 13 0.036 0.031 0.444 0.34 0.15 Cyprus 10148 7 0.036 0.029 0.791 0.06 0.084
Turkey 6743 5 0.013 0.063 0.51 0.368 0.046 Cyprus 10149 7 0.021 0.2 0.436 0.321 0.023
Turkey 6745 7 0.04 0.018 0.093 0.841 0.008 Cyprus 10150 2 0.011 0.019 0.925 0.019 0.026
Turkey 6746 5 0.073 0.028 0.067 0.468 0.363 Cyprus 10151 2 0.019 0.042 0.88 0.04 0.018
Turkey 6748 10 0.008 0.012 0.859 0.103 0.018 Cyprus 10152 5 0.048 0.015 0.887 0.016 0.035
Turkey 6749 10 0.012 0.067 0.036 0.878 0.006 Cyprus 10153 0 0.015 0.02 0.924 0.026 0.014
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Cyprus 10154 0 0.011 0.129 0.709 0.038 0.112 Lebanon 10265 7 0.009 0.12 0.841 0.02 0.01
Cyprus 10155 5 0.016 0.008 0.851 0.018 0.107 Lebanon 10266 0 0.013 0.014 0.822 0.037 0.114
Cyprus 10156 7 0.125 0.017 0.752 0.09 0.016 Lebanon 10267 18 0.008 0.007 0.893 0.085 0.007
Cyprus 10157 2 0.009 0.042 0.931 0.01 0.009 Lebanon 10268 5 0.018 0.005 0.914 0.028 0.035
Lebanon 10235 10 0.045 0.046 0.769 0.069 0.07 Lebanon 10270 13 0.107 0.117 0.637 0.027 0.113
Lebanon 10236 13 0.045 0.024 0.843 0.047 0.04 Lebanon 10271 18 0.032 0.22 0.088 0.524 0.136
Lebanon 10237 5 0.044 0.01 0.56 0.024 0.363 Lebanon 10273 10 0.053 0.068 0.517 0.309 0.052
Lebanon 10238 5 0.011 0.042 0.905 0.013 0.029 Lebanon 10274 13 0.065 0.009 0.307 0.029 0.591
Lebanon 10239 5 0.01 0.011 0.953 0.015 0.011 Lebanon 10276 10 0.005 0.014 0.931 0.015 0.035
Lebanon 10240 15 0.029 0.033 0.778 0.037 0.122 Lebanon 10277 2 0.18 0.045 0.669 0.087 0.019
Lebanon 10241 13 0.105 0.053 0.53 0.265 0.047 Lebanon 10278 15 0.039 0.02 0.89 0.026 0.025
Lebanon 10242 7 0.007 0.031 0.883 0.066 0.014 Lebanon 10279 0 0.01 0.051 0.835 0.015 0.089
Lebanon 10243 10 0.058 0.05 0.76 0.039 0.093 Lebanon 10280 0 0.021 0.046 0.497 0.056 0.381
Lebanon 10244 5 0.049 0.104 0.786 0.02 0.042 Lebanon 10281 10 0.009 0.046 0.925 0.01 0.01
Lebanon 10245 13 0.01 0.268 0.592 0.072 0.058 Lebanon 10282 10 0.011 0.022 0.906 0.012 0.049
Lebanon 10246 2 0.004 0.024 0.94 0.013 0.018 Lebanon 10283 23 0.008 0.01 0.945 0.021 0.016
Lebanon 10247 18 0.012 0.289 0.671 0.015 0.014 Lebanon 10284 23 0.04 0.105 0.607 0.051 0.197
Lebanon 10248 7 0.007 0.01 0.884 0.089 0.01 Lebanon 10285 2 0.168 0.017 0.727 0.063 0.025
Lebanon 10249 13 0.013 0.016 0.181 0.75 0.04 Lebanon 10286 15 0.02 0.305 0.551 0.015 0.108
Lebanon 10250 2 0.023 0.138 0.748 0.081 0.01 Lebanon 10287 5 0.074 0.055 0.321 0.38 0.171
Lebanon 10251 2 0.006 0.013 0.872 0.097 0.012 Lebanon 10288 13 0.01 0.004 0.023 0.958 0.005
Lebanon 10252 5 0.019 0.09 0.579 0.3 0.011 Lebanon 10289 13 0.009 0.029 0.931 0.01 0.021
Lebanon 10253 15 0.006 0.008 0.938 0.042 0.005 Lebanon 10290 5 0.095 0.033 0.59 0.011 0.271
Lebanon 10254 13 0.023 0.04 0.867 0.016 0.053 Lebanon 10291 15 0.066 0.147 0.732 0.023 0.033
Lebanon 10255 7 0.026 0.174 0.702 0.078 0.02 Lebanon 10292 13 0.054 0.077 0.386 0.032 0.45
Lebanon 10256 18 0.007 0.008 0.969 0.01 0.006 Lebanon 10294 2 0.033 0.056 0.74 0.062 0.109
Lebanon 10257 5 0.026 0.071 0.84 0.007 0.056 Lebanon 10295 7 0.023 0.08 0.781 0.05 0.066
Lebanon 10258 7 0.008 0.015 0.933 0.024 0.02 Lebanon 10297 5 0.03 0.128 0.798 0.025 0.02
Lebanon 10259 10 0.014 0.01 0.058 0.085 0.833 Lebanon 10298 10 0.029 0.495 0.38 0.018 0.079
Lebanon 10260 2 0.011 0.021 0.939 0.011 0.018 Lebanon 10299 2 0.114 0.085 0.247 0.388 0.166
Lebanon 10261 10 0.015 0.077 0.824 0.069 0.015 Lebanon 10300 2 0.021 0.083 0.835 0.018 0.042
Lebanon 10262 5 0.068 0.062 0.678 0.139 0.052 Israel 4962 7 0.007 0.152 0.79 0.033 0.019
Lebanon 10263 7 0.008 0.011 0.949 0.011 0.021 Israel 4963 5 0.017 0.031 0.893 0.028 0.031
Lebanon 10264 5 0.017 0.015 0.808 0.092 0.067 Israel 4964 7 0.013 0.102 0.333 0.531 0.02
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Israel 4966 5 0.008 0.009 0.898 0.03 0.054 Israel 5003 7 0.028 0.01 0.883 0.071 0.008
Israel 4967 5 0.108 0.021 0.519 0.317 0.036 Israel 5004 15 0.015 0.028 0.313 0.513 0.131
Israel 4968 7 0.028 0.041 0.877 0.024 0.03 Israel 5005 7 0.008 0.018 0.837 0.116 0.021
Israel 4969 2 0.065 0.018 0.557 0.307 0.053 Israel 5006 10 0.006 0.012 0.95 0.027 0.005
Israel 4970 7 0.022 0.054 0.691 0.138 0.096 Israel 5007 5 0.269 0.01 0.145 0.464 0.112
Israel 4971 2 0.065 0.077 0.75 0.038 0.069 Israel 5008 5 0.011 0.035 0.912 0.025 0.017
Israel 4972 10 0.03 0.016 0.828 0.089 0.037 Israel 5009 13 0.055 0.101 0.376 0.381 0.087
Israel 4973 5 0.01 0.011 0.951 0.017 0.012 Israel 5010 15 0.008 0.009 0.927 0.048 0.008
Israel 4974 5 0.009 0.029 0.888 0.052 0.023 Israel 5011 13 0.016 0.043 0.792 0.119 0.029
Israel 4975 2 0.007 0.015 0.832 0.132 0.014 Egypt-Cairo 8190 15 0.01 0.01 0.895 0.065 0.022
Israel 4976 5 0.007 0.016 0.629 0.302 0.046 Egypt-Cairo 8192 18 0.015 0.033 0.668 0.099 0.186
Israel 4977 15 0.01 0.035 0.625 0.316 0.014 Egypt-Cairo 8193 18 0.005 0.019 0.957 0.009 0.01
Israel 4978 10 0.019 0.107 0.634 0.179 0.061 Egypt-Cairo 8196 15 0.038 0.015 0.85 0.021 0.076
Israel 4979 7 0.01 0.024 0.91 0.048 0.007 Egypt-Cairo 8203 15 0.024 0.008 0.927 0.022 0.02
Israel 4980 2 0.157 0.161 0.421 0.113 0.148 Egypt-Cairo 8215 10 0.008 0.007 0.97 0.008 0.008
Israel 4981 15 0.158 0.039 0.778 0.013 0.012 Egypt-Cairo 8198 10 0.021 0.015 0.889 0.057 0.017
Israel 4982 10 0.012 0.008 0.676 0.269 0.035 Egypt-Cairo 8194 7 0.019 0.014 0.849 0.099 0.019
Israel 4983 7 0.109 0.03 0.027 0.797 0.036 Egypt-Cairo 8211 5 0.011 0.03 0.928 0.022 0.009
Israel 4984 2 0.033 0.006 0.009 0.926 0.025 Egypt-Cairo 8216 7 0.013 0.011 0.72 0.246 0.011
Israel 4985 21 0.034 0.012 0.865 0.022 0.067 Egypt-Cairo 8195 5 0.035 0.02 0.853 0.013 0.079
Israel 4986 5 0.015 0.013 0.947 0.016 0.01 Egypt-Cairo 8199 2 0.006 0.01 0.943 0.008 0.033
Israel 4988 13 0.027 0.03 0.896 0.02 0.028 Egypt-Cairo 8200 5 0.01 0.018 0.915 0.051 0.006
Israel 4989 5 0.016 0.059 0.825 0.01 0.091 Egypt-Cairo 8201 5 0.102 0.101 0.748 0.024 0.025
Israel 4990 5 0.034 0.011 0.88 0.039 0.036 Egypt-Cairo 8202 5 0.038 0.02 0.042 0.034 0.866
Israel 4992 7 0.007 0.007 0.763 0.213 0.01 Egypt-Cairo 8204 5 0.022 0.009 0.917 0.02 0.032
Israel 4993 7 0.008 0.011 0.95 0.02 0.011 Egypt-Cairo 8208 2 0.08 0.016 0.78 0.099 0.025
Israel 4994 5 0.007 0.006 0.97 0.012 0.005 Egypt-Cairo 8210 5 0.007 0.05 0.891 0.013 0.04
Israel 4995 5 0.026 0.063 0.85 0.02 0.041 Egypt-Cairo 8214 2 0.006 0.006 0.977 0.007 0.004
Israel 4996 2 0.02 0.026 0.933 0.012 0.009 Egypt-Cairo 8191 5 0.074 0.045 0.784 0.051 0.046
Israel 4997 15 0.012 0.086 0.853 0.017 0.032 Egypt-Cairo 8197 2 0.01 0.02 0.915 0.008 0.047
Israel 4998 10 0.019 0.037 0.583 0.322 0.039 Egypt-Cairo 8205 2 0.023 0.011 0.83 0.076 0.059
Israel 5000 7 0.025 0.021 0.752 0.017 0.185 Egypt-Cairo 8206 2 0.017 0.008 0.841 0.091 0.043
Israel 5001 5 0.013 0.051 0.791 0.128 0.018 Egypt-Cairo 8207 2 0.027 0.013 0.894 0.023 0.044
Israel 5002 7 0.012 0.012 0.855 0.098 0.024 Egypt-Cairo 8209 2 0.008 0.006 0.939 0.041 0.005
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Cairo 8212 2 0.009 0.009 0.969 0.008 0.005 Egypt-Cairo 10030 0 0.03 0.009 0.902 0.048 0.011
Egypt-Cairo 8213 2 0.008 0.011 0.964 0.011 0.006 Egypt-Cairo 10031 2 0.005 0.018 0.964 0.005 0.008
Egypt-Cairo 9942 0 0.035 0.223 0.7 0.011 0.031 Egypt-Cairo 10032 0 0.006 0.027 0.956 0.005 0.006
Egypt-Cairo 9943 15 0.336 0.014 0.01 0.252 0.388 Egypt-Cairo 10033 2 0.014 0.005 0.956 0.006 0.019
Egypt-Cairo 9944 7 0.004 0.028 0.907 0.052 0.01 Egypt-Cairo 10034 0 0.008 0.008 0.965 0.01 0.009
Egypt-Cairo 9945 2 0.012 0.015 0.797 0.161 0.015 Egypt-Cairo 10035 0 0.175 0.012 0.765 0.01 0.038
Egypt-Cairo 9946 13 0.048 0.03 0.803 0.018 0.1 Egypt-Cairo 10037 5 0.011 0.014 0.843 0.081 0.052
Egypt-Cairo 9947 7 0.01 0.038 0.917 0.021 0.014 Egypt-Cairo 10042 0 0.026 0.031 0.834 0.029 0.08
Egypt-Cairo 9948 0 0.02 0.007 0.901 0.051 0.019 Egypt-Cairo 10043 7 0.005 0.009 0.924 0.047 0.016
Egypt-Cairo 9949 0 0.022 0.019 0.894 0.05 0.016 Egypt-Cairo 10044 2 0.009 0.007 0.954 0.016 0.014
Egypt-Cairo 9950 0 0.019 0.015 0.807 0.096 0.062 Egypt-Cairo 10045 2 0.017 0.012 0.933 0.017 0.021
Egypt-Cairo 9951 5 0.012 0.004 0.952 0.02 0.012 Egypt-Cairo 10046 0 0.039 0.007 0.891 0.025 0.038
Egypt-Cairo 9952 15 0.01 0.01 0.689 0.277 0.013 Egypt-Cairo 10047 0 0.022 0.025 0.922 0.012 0.019
Egypt-Cairo 9953 21 0.009 0.085 0.731 0.158 0.017 Egypt-Cairo 10048 2 0.02 0.004 0.909 0.05 0.018
Egypt-Cairo 9954 2 0.14 0.007 0.816 0.019 0.019 Egypt-Cairo 10083 21 0.01 0.006 0.907 0.062 0.014
Egypt-Cairo 9955 0 0.061 0.007 0.214 0.566 0.152 Egypt-Cairo 10040 0 0.045 0.019 0.463 0.437 0.036
Egypt-Cairo 9956 18 0.043 0.019 0.899 0.027 0.012 Egypt-Cairo 10041 0 0.031 0.01 0.487 0.439 0.033
Egypt-Cairo 9957 5 0.09 0.009 0.868 0.02 0.013 Egypt-Cairo 10049 5 0.028 0.028 0.89 0.024 0.03
Egypt-Cairo 9958 15 0.038 0.007 0.876 0.044 0.035 Egypt-Cairo 10084 2 0.015 0.012 0.93 0.017 0.027
Egypt-Cairo 9959 5 0.03 0.027 0.687 0.214 0.043 Egypt-Cairo 10085 23 0.012 0.011 0.861 0.066 0.049
Egypt-Cairo 9960 2 0.03 0.053 0.882 0.024 0.011 Egypt-Cairo 10087 5 0.007 0.004 0.973 0.008 0.008
Egypt-Cairo 9961 5 0.074 0.014 0.205 0.15 0.557 Egypt-Cairo 10090 7 0.067 0.009 0.871 0.02 0.033
Egypt-Cairo 9962 7 0.01 0.069 0.882 0.019 0.02 Egypt-Cairo 9968 0 0.006 0.027 0.911 0.039 0.017
Egypt-Cairo 9963 2 0.021 0.013 0.925 0.025 0.016 Egypt-Asuit 10091 2 0.007 0.007 0.956 0.021 0.009
Egypt-Cairo 9964 0 0.009 0.006 0.942 0.023 0.02 Egypt-Asuit 10093 0 0.006 0.005 0.962 0.016 0.011
Egypt-Cairo 10021 0 0.006 0.009 0.971 0.008 0.007 Egypt-Asuit 10094 5 0.008 0.007 0.959 0.012 0.015
Egypt-Cairo 10022 0 0.03 0.006 0.924 0.023 0.016 Egypt-Asuit 10095 2 0.005 0.009 0.959 0.012 0.016
Egypt-Cairo 10023 0 0.01 0.004 0.958 0.006 0.021 Egypt-Asuit 10096 0 0.015 0.005 0.96 0.011 0.009
Egypt-Cairo 10024 0 0.015 0.009 0.911 0.057 0.009 Egypt-Asuit 10098 0 0.006 0.004 0.975 0.007 0.007
Egypt-Cairo 10025 0 0.005 0.014 0.819 0.149 0.013 Egypt-Asuit 10099 5 0.007 0.005 0.974 0.006 0.008
Egypt-Cairo 10026 2 0.045 0.009 0.914 0.022 0.011 Egypt-Asuit 10100 2 0.093 0.042 0.721 0.081 0.063
Egypt-Cairo 10027 0 0.019 0.023 0.639 0.089 0.229 Egypt-Asuit 10101 2 0.021 0.017 0.919 0.015 0.028
Egypt-Cairo 10028 0 0.013 0.026 0.941 0.006 0.015 Egypt-Asuit 10102 0 0.023 0.014 0.772 0.009 0.182
Egypt-Cairo 10029 0 0.008 0.021 0.959 0.006 0.006 Egypt- Luxor 10038 0 0.044 0.008 0.915 0.01 0.023
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Luxor 10039 2 0.005 0.051 0.932 0.008 0.005 Simbel
Egypt-Luxor 10050 2 0.048 0.015 0.897 0.009 0.031 Egypt-Abu
Egypt-Luxor 10051 0 0.005 0.005 0.969 0.012 0.009 Simbel 10092 0 0.013 0.01 0.962 0.006 0.009
Egypt-Luxor 10052 0 0.018 0.015 0.81 0.023 0.134 Iraq-West 9587 0 0.02 0.725 0.091 0.026 0.138
Egypt-Luxor 10053 0 0.006 0.074 0.863 0.027 0.03 Iraq-West 10202 23 0.015 0.746 0.191 0.031 0.017
Egypt-Luxor 10054 0 0.065 0.02 0.877 0.021 0.018 Iraq-West 10204 23 0.006 0.763 0.166 0.051 0.013
Egypt-Luxor 10055 0 0.008 0.01 0.956 0.014 0.012 Iraq-West 11854 0 0.037 0.879 0.06 0.013 0.009
Egypt-Luxor 10056 0 0.049 0.024 0.91 0.009 0.008 Iraq-West 11860 21 0.008 0.881 0.017 0.006 0.088
Egypt-Luxor 10057 7 0.026 0.079 0.858 0.016 0.02 Iraq-West 11861 7 0.257 0.549 0.157 0.02 0.017
Egypt-Luxor 10058 0 0.01 0.008 0.962 0.014 0.006 Iraq-West 11863 21 0.016 0.94 0.009 0.022 0.012
Egypt-Luxor 10060 0 0.011 0.011 0.922 0.047 0.009 Iraq-West 11864 2 0.033 0.901 0.026 0.007 0.032
Egypt-Luxor 10061 0 0.443 0.008 0.449 0.017 0.084 Iraq-West 11888 5 0.015 0.946 0.007 0.004 0.028
Egypt-Luxor 10062 5 0.023 0.01 0.893 0.063 0.011 Iraq-West 11889 7 0.016 0.7 0.03 0.224 0.029
Egypt-Luxor 10063 2 0.024 0.071 0.841 0.026 0.039 Iraq-West 11890 2 0.103 0.695 0.157 0.015 0.031
Egypt-Luxor 10064 0 0.029 0.013 0.88 0.021 0.057 Iraq-West 11891 0 0.009 0.632 0.308 0.037 0.014
Egypt-Luxor 10065 0 0.008 0.015 0.893 0.03 0.054 Iraq-Baghdad 11847 5 0.017 0.858 0.081 0.015 0.029
Egypt-Luxor 10066 2 0.05 0.015 0.841 0.067 0.026 Iraq-Baghdad 11848 0 0.081 0.773 0.017 0.013 0.116
Egypt-Luxor 10067 2 0.005 0.018 0.961 0.008 0.008 Iraq-Baghdad 11849 5 0.055 0.782 0.108 0.014 0.042
Egypt-Luxor 10068 0 0.119 0.004 0.812 0.014 0.05 Iraq-Baghdad 11850 0 0.021 0.902 0.017 0.045 0.015
Egypt-Luxor 10069 2 0.007 0.009 0.958 0.012 0.014 Iraq-Baghdad 11852 0 0.02 0.868 0.039 0.016 0.057
Egypt-Luxor 10070 0 0.422 0.007 0.465 0.021 0.085 Iraq-Baghdad 11853 5 0.029 0.908 0.02 0.009 0.035
Egypt-Luxor 10071 2 0.143 0.023 0.772 0.017 0.045 Iraq-Baghdad 11855 5 0.021 0.874 0.049 0.01 0.047
Egypt-Luxor 10072 2 0.03 0.008 0.946 0.008 0.008 Iraq-Baghdad 11856 2 0.008 0.842 0.064 0.052 0.034
Egypt-Luxor 10073 5 0.008 0.006 0.04 0.935 0.011 Iraq-Baghdad 11857 0 0.016 0.578 0.158 0.233 0.014
Egypt-Luxor 10074 0 0.008 0.005 0.972 0.008 0.007 Iraq-Baghdad 11858 2 0.008 0.956 0.013 0.012 0.011
Egypt-Luxor 10079 0 0.007 0.014 0.778 0.085 0.116 Iraq-Baghdad 11859 5 0.017 0.85 0.056 0.026 0.051
Egypt-Luxor 10080 0 0.021 0.017 0.591 0.059 0.311 Iraq-Baghdad 11862 2 0.274 0.562 0.06 0.083 0.02
Egypt-Abu Iraq-Baghdad 11865 5 0.197 0.624 0.107 0.011 0.061
Simbel 10076 5 0.088 0.007 0.857 0.019 0.03 Iraq-Baghdad 11868 2 0.009 0.965 0.011 0.007 0.009
Egypt-Abu Iraq-Baghdad 11869 2 0.027 0.652 0.083 0.224 0.014
Simbel 10077 13 0.019 0.007 0.888 0.009 0.077 Iraq-Baghdad 11870 0 0.102 0.707 0.111 0.057 0.022
Egypt-Abu Iraq-Baghdad 11871 5 0.011 0.507 0.416 0.009 0.056
Simbel 10081 7 0.02 0.01 0.927 0.015 0.028 Iraq-Baghdad 11872 2 0.005 0.711 0.25 0.021 0.012
Egypt-Abu 10089 0 0.004 0.004 0.881 0.102 0.008 Iraq-Baghdad 11873 7 0.042 0.551 0.379 0.008 0.02
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5 raq-Baghdad 11874 2 0.062 0.859 0.054 0.016 0.01 Iran 9440 2 0.005 0.963 0.014 0.004 0.014 raq-Baghdad 11875 15 0.186 0.587 0.013 0.011 0.204 Iran 9441 7 0.006 0.974 0.005 0.005 0.009 raq-Baghdad 11876 21 0.029 0.806 0.082 0.013 0.07 Iran 9442 5 0.014 0.873 0.019 0.023 0.071 raq-Baghdad 11877 7 0.068 0.848 0.055 0.012 0.017 Iran 9443 10 0.013 0.953 0.009 0.013 0.013 raq-Baghdad 11878 7 0.015 0.535 0.374 0.055 0.02 Iran 9444 5 0.006 0.981 0.005 0.004 0.004 raq-Baghdad 11879 2 0.021 0.771 0.029 0.01 0.168 Iran 9445 5 0.004 0.983 0.003 0.003 0.006 raq-Baghdad 11880 10 0.01 0.906 0.053 0.012 0.018 Iran 9446 10 0.014 0.962 0.006 0.005 0.013 raq-Baghdad 11881 0 0.115 0.634 0.155 0.069 0.027 Iran 9447 7 0.007 0.967 0.005 0.009 0.012 raq-Baghdad 11882 15 0.017 0.826 0.122 0.018 0.017 Iran 9448 13 0.005 0.977 0.005 0.005 0.008 raq-Baghdad 11883 0 0.013 0.67 0.108 0.182 0.026 Iran 9449 5 0.003 0.985 0.004 0.004 0.004 raq-Baghdad 11884 0 0.015 0.961 0.006 0.005 0.012 Iran 9450 7 0.025 0.947 0.016 0.005 0.006 raq-Baghdad 11885 0 0.011 0.949 0.021 0.005 0.013 Iran 9451 10 0.098 0.867 0.011 0.007 0.016 raq-Baghdad 11886 0 0.088 0.605 0.236 0.014 0.058 Iran 9452 2 0.01 0.952 0.008 0.009 0.022 raq-Baghdad 11887 13 0.05 0.814 0.066 0.016 0.054 Iran 9453 7 0.004 0.978 0.006 0.007 0.005 ran 9419 2 0.043 0.769 0.047 0.128 0.012 Iran 9454 7 0.005 0.98 0.006 0.005 0.005 ran 9420 2 0.131 0.822 0.015 0.008 0.023 Iran 9455 13 0.008 0.958 0.011 0.008 0.014 ran 9421 5 0.013 0.95 0.018 0.012 0.006 Iran 9456 2 0.021 0.926 0.015 0.017 0.02 ran 9422 5 0.13 0.751 0.088 0.02 0.011 Iran 9457 5 0.004 0.975 0.01 0.006 0.005 ran 9424 7 0.125 0.853 0.006 0.005 0.011 Iran 9458 2 0.014 0.958 0.01 0.005 0.012 ran 9425 7 0.017 0.965 0.005 0.004 0.008 Iran 9459 5 0.006 0.978 0.004 0.004 0.007 ran 9426 2 0.012 0.957 0.008 0.013 0.01 Iran 9460 10 0.014 0.925 0.018 0.023 0.02 ran 9427 2 0.006 0.963 0.01 0.012 0.009 Iran 9461 10 0.005 0.973 0.006 0.006 0.01 ran 9428 5 0.01 0.968 0.007 0.007 0.008 Iran 9462 10 0.008 0.941 0.008 0.019 0.024 ran 9429 15 0.095 0.821 0.029 0.017 0.039 Iran 9463 15 0.008 0.965 0.012 0.006 0.009 ran 9430 7 0.05 0.865 0.031 0.021 0.033 Iran 9464 7 0.011 0.972 0.006 0.004 0.007 ran 9431 7 0.064 0.747 0.038 0.021 0.129 Iran 9465 5 0.005 0.968 0.009 0.008 0.01 ran 9432 13 0.008 0.957 0.006 0.006 0.023 Iran 9466 13 0.006 0.931 0.027 0.014 0.022 ran 9433 5 0.034 0.931 0.013 0.01 0.013 Iran 9468 10 0.029 0.916 0.016 0.029 0.01 ran 9434 7 0.127 0.754 0.013 0.041 0.065 Iran 9469 10 0.038 0.861 0.029 0.028 0.043 ran 9435 5 0.017 0.923 0.007 0.009 0.043 Iran 9470 13 0.022 0.921 0.017 0.021 0.018 ran 9436 2 0.008 0.962 0.012 0.01 0.008 Iran 9471 7 0.005 0.969 0.008 0.01 0.008 ran 9437 2 0.009 0.952 0.013 0.01 0.017 Iran 9472 10 0.01 0.958 0.015 0.006 0.01 ran 9438 2 0.015 0.956 0.005 0.007 0.017 Iran 9473 5 0.01 0.969 0.006 0.006 0.01 ran 9439 5 0.155 0.729 0.043 0.028 0.044 Iran 9474 7 0.006 0.959 0.014 0.011 0.01
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Iran 9475 7 0.004 0.962 0.015 0.009 0.009 Iran 9510 15 0.069 0.908 0.007 0.007 0.009
Iran 9476 7 0.012 0.975 0.006 0.004 0.004 Iran 9511 13 0.007 0.959 0.008 0.02 0.006
Iran 9477 7 0.068 0.902 0.009 0.012 0.008 Iran 9512 28 0.015 0.812 0.03 0.117 0.026
Iran 9478 5 0.031 0.796 0.017 0.012 0.144 Iran 9513 21 0.007 0.952 0.013 0.013 0.015
Iran 9479 7 0.012 0.975 0.004 0.004 0.005 Iran 9514 15 0.015 0.773 0.123 0.053 0.036
Iran 9480 13 0.017 0.939 0.008 0.013 0.022 Iran 9515 13 0.008 0.791 0.01 0.165 0.025
Iran 9481 10 0.008 0.958 0.018 0.009 0.007 Iran 9516 15 0.01 0.922 0.015 0.016 0.037
Iran 9482 5 0.039 0.878 0.033 0.021 0.03 Iran 9517 13 0.059 0.823 0.019 0.04 0.058
Iran 9483 13 0.195 0.73 0.013 0.014 0.047 Iran 9518 13 0.026 0.712 0.04 0.199 0.024
Iran 9484 2 0.007 0.713 0.187 0.079 0.015 Iran 9519 18 0.008 0.887 0.016 0.074 0.015
Iran 9485 10 0.101 0.862 0.013 0.006 0.019 Iran 9520 15 0.006 0.86 0.023 0.086 0.025
Iran 9486 10 0.007 0.944 0.012 0.027 0.009 Iran 9521 21 0.01 0.874 0.017 0.02 0.078
Iran 9487 5 0.011 0.951 0.008 0.006 0.024 Iran 9522 15 0.075 0.642 0.191 0.05 0.042
Iran 9488 10 0.007 0.967 0.01 0.009 0.007 Iran 9523 13 0.011 0.835 0.104 0.037 0.014
Iran 9489 15 0.009 0.922 0.01 0.007 0.052 Iran 9524 15 0.054 0.923 0.007 0.005 0.01
Iran 9490 13 0.014 0.961 0.005 0.007 0.014 Iran 9526 15 0.12 0.853 0.009 0.005 0.012
Iran 9491 7 0.006 0.981 0.005 0.004 0.005 Iran 9527 13 0.028 0.852 0.023 0.024 0.073
Iran 9492 10 0.005 0.969 0.006 0.007 0.014 Iran 9528 15 0.007 0.977 0.004 0.005 0.006
Iran 9493 2 0.023 0.952 0.008 0.008 0.01 Iran 9529 15 0.03 0.935 0.005 0.003 0.027
Iran 9494 7 0.004 0.972 0.012 0.006 0.006 Iran 9530 10 0.047 0.926 0.009 0.009 0.01
Iran 9495 5 0.007 0.971 0.005 0.006 0.011 Iran 9531 15 0.033 0.784 0.05 0.045 0.088
Iran 9497 10 0.005 0.971 0.005 0.006 0.012 Iran 9532 5 0.006 0.974 0.006 0.006 0.008
Iran 9498 10 0.013 0.965 0.008 0.006 0.008 Dubai 10104 2 0.004 0.298 0.178 0.038 0.482
Iran 9499 5 0.102 0.868 0.009 0.006 0.015 Dubai 10105 2 0.024 0.189 0.018 0.018 0.751
Iran 9500 7 0.006 0.97 0.004 0.005 0.015 Dubai 10106 18 0.007 0.023 0.015 0.007 0.947
Iran 9501 2 0.009 0.854 0.035 0.047 0.056 Dubai 10107 5 0.165 0.384 0.039 0.045 0.367
Iran 9502 5 0.279 0.693 0.012 0.009 0.007 Dubai 10108 2 0.034 0.029 0.026 0.011 0.9
Iran 9503 7 0.008 0.973 0.004 0.004 0.011 Dubai 10109 18 0.194 0.53 0.023 0.029 0.224
Iran 9504 5 0.004 0.984 0.005 0.004 0.003 Dubai 10110 7 0.016 0.364 0.025 0.045 0.55
Iran 9505 5 0.007 0.985 0.003 0.002 0.003 Dubai 10111 13 0.009 0.019 0.017 0.006 0.949
Iran 9506 7 0.01 0.919 0.009 0.019 0.043 Dubai 10112 7 0.037 0.024 0.098 0.046 0.794
Iran 9507 31 0.044 0.885 0.028 0.015 0.028 Dubai 10120 15 0.008 0.059 0.016 0.017 0.9
Iran 9508 10 0.121 0.844 0.009 0.006 0.02 Kenya-Nairobi 9833 13 0.047 0.202 0.023 0.593 0.135
Iran 9509 18 0.043 0.929 0.01 0.009 0.01 Kenya-Nairobi 9834 0 0.02 0.009 0.017 0.709 0.245
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kenya- Nairobi 9835 0 0.208 0.009 0.075 0.534 0.173 Kenya-Pate 2000 7 0.005 0.007 0.042 0.175 0.77
Kenya- Nairobi 9836 2 0.033 0.013 0.01 0.673 0.27 Kenya-Pate 2001 13 0.005 0.166 0.016 0.006 0.807
Kenya- Nairobi 9837 0 0.116 0.056 0.028 0.759 0.041 Kenya-Pate 2002 2 0.01 0.174 0.013 0.005 0.798
Kenya-Nairobi 9838 2 0.024 0.239 0.087 0.614 0.036 Kenya-Pate 2003 2 0.024 0.017 0.014 0.016 0.928
Kenya-Nairobi 9839 0 0.03 0.02 0.036 0.221 0.694 Kenya-Pate 2004 10 0.007 0.031 0.058 0.024 0.88
Kenya- Nairobi 9840 0 0.012 0.017 0.325 0.466 0.18 Kenya-Pate 2006 7 0.075 0.064 0.044 0.014 0.802
Kenya- Nairobi 9841 2 0.013 0.01 0.016 0.805 0.157 Kenya-Pate 2007 7 0.01 0.036 0.032 0.033 0.888
Kenya- Nairobi 9842 2 0.127 0.053 0.041 0.71 0.069 Kenya-Pate 2009 28 0.007 0.017 0.313 0.053 0.61
Kenya- Nairobi 9843 0 0.014 0.011 0.017 0.752 0.206 Kenya-Pate 2011 13 0.006 0.004 0.026 0.012 0.953
Kenya- Nairobi 9844 2 0.062 0.01 0.018 0.821 0.089 Kenya-Lamu 1848 10 0.015 0.014 0.023 0.013 0.935
Kenya- Nairobi 9845 0 0.056 0.024 0.188 0.69 0.042 Kenya-Lamu 2014 5 0.005 0.01 0.042 0.011 0.932
Kenya- Nairobi 9846 2 0.157 0.016 0.033 0.579 0.216 Kenya-Lamu 2015 7 0.023 0.019 0.775 0.023 0.16
Kenya-Nairobi 9847 0 0.022 0.02 0.016 0.839 0.103 Kenya-Lamu 2016 7 0.007 0.009 0.066 0.07 0.848
Kenya-Nairobi 9848 0 0.112 0.033 0.214 0.583 0.058 Kenya-Lamu 2018 2 0.01 0.036 0.373 0.055 0.526
Kenya- Nairobi 9849 5 0.024 0.009 0.062 0.19 0.715 Kenya-Lamu 2019 7 0.007 0.009 0.055 0.04 0.889
Kenya- Nairobi 9850 7 0.018 0.022 0.067 0.784 0.109 Kenya-Lamu 2021 7 0.005 0.187 0.033 0.022 0.753
Kenya- Nairobi 9851 2 0.008 0.008 0.008 0.518 0.457 Kenya-Lamu 2023 13 0.008 0.008 0.074 0.042 0.867
Kenya- Nairobi 9852 7 0.005 0.008 0.092 0.52 0.375 Kenya-Lamu 2024 2 0.006 0.042 0.017 0.009 0.927
Kenya- Nairobi 9853 2 0.029 0.083 0.016 0.766 0.107 Kenya-Lamu 2025 5 0.02 0.039 0.106 0.012 0.823
Kenya- Nairobi 9854 0 0.007 0.088 0.035 0.824 0.046 Kenya-Lamu 2026 18 0.006 0.008 0.032 0.006 0.949
Kenya- Nairobi 9855 2 0.009 0.023 0.166 0.517 0.285 Kenya-Lamu 2027 26 0.014 0.092 0.047 0.053 0.794
Kenya- Nairobi 9856 2 0.013 0.008 0.024 0.665 0.29 Kenya-Lamu 2029 5 0.006 0.033 0.016 0.008 0.938
Kenya-Nairobi 9857 23 0.13 0.014 0.043 0.505 0.309 Kenya-Lamu 2030 5 0.006 0.011 0.024 0.132 0.827
Kenya-Nairobi 9858 15 0.057 0.009 0.015 0.837 0.081 Kenya-Lamu 2031 18 0.038 0.079 0.163 0.301 0.419
Kenya- Nairobi 9859 15 0.105 0.021 0.007 0.817 0.05 Kenya-Lamu 2032 10 0.01 0.251 0.023 0.02 0.696
Kenya- Nairobi 9860 5 0.071 0.016 0.012 0.839 0.062 Kenya-Lamu 2033 13 0.008 0.02 0.13 0.023 0.818
Kenya- Nairobi 9861 2 0.007 0.013 0.048 0.897 0.035 Kenya-Lamu 3241 18 0.045 0.011 0.073 0.061 0.81
Kenya- Nairobi 9862 7 0.028 0.006 0.094 0.505 0.367 Kenya-Lamu 3246 7 0.015 0.021 0.832 0.017 0.114
Kenya- Nairobi 9863 2 0.02 0.011 0.008 0.612 0.35 Kenya-Lamu 3247 13 0.01 0.024 0.073 0.127 0.765
Kenya- Nairobi 9864 7 0.005 0.087 0.022 0.683 0.204 India-Udaipur 11835 10 0.237 0.215 0.16 0.034 0.354
Kenya- Nairobi 9865 10 0.06 0.065 0.079 0.36 0.436 India-Udaipur 11836 5 0.027 0.34 0.026 0.01 0.596
Kenya- Nairobi 9866 7 0.032 0.007 0.177 0.641 0.143 India-Udaipur 11837 5 0.038 0.32 0.017 0.007 0.618
Kenya-Nairobi 9867 0 0.044 0.052 0.085 0.361 0.458 India-Agra 11823 0 0.008 0.447 0.015 0.008 0.522
Kenya- Nairobi 9868 5 0.008 0.014 0.286 0.523 0.169 India-Agra 11824 0 0.007 0.223 0.016 0.006 0.747
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
India-Agra 11825 2 0.013 0.494 0.012 0.013 0.468 India-
India-Agra 11826 7 0.007 0.473 0.007 0.007 0.506 Hyderbad 11815 0 0.024 0.048 0.008 0.007 0.913
India-Agra 11827 0 0.008 0.407 0.015 0.005 0.566 India-
India-Agra 11828 5 0.019 0.35 0.033 0.007 0.591 Hyderbad 11816 0 0.007 0.023 0.019 0.007 0.944
India-Agra 11829 5 0.012 0.166 0.035 0.023 0.764 India-
India-Agra 11830 5 0.009 0.37 0.014 0.005 0.602 Hyderbad 11817 5 0.016 0.012 0.009 0.008 0.956
India-Agra 11831 5 0.01 0.442 0.041 0.013 0.495 India-
India-Agra 11832 0 0.009 0.509 0.012 0.006 0.464 Hyderbad 11818 2 0.048 0.01 0.007 0.005 0.929
India-Agra 11833 2 0.022 0.47 0.015 0.006 0.487 India-
India-Agra 11834 5 0.007 0.48 0.007 0.007 0.499 Hyderbad 11819 0 0.007 0.022 0.02 0.007 0.943
India- India-
Hyderbad 11802 7 0.047 0.013 0.443 0.044 0.452 Hyderbad 11820 5 0.075 0.022 0.008 0.006 0.888
India- India-
Hyderbad 11803 7 0.014 0.04 0.134 0.011 0.8 Hyderbad 11821 0 0.046 0.035 0.04 0.012 0.867
India- India-
Hyderbad 11804 10 0.408 0.092 0.012 0.011 0.476 Hyderbad 11822 0 0.065 0.012 0.044 0.017 0.862
India- India-Andhra 10159 5 0.087 0.005 0.019 0.014 0.875
Hyderbad 11805 5 0.038 0.016 0.02 0.025 0.901 India-Andhra 10160 2 0.232 0.01 0.01 0.011 0.736
India- India-Andhra 10161 0 0.012 0.014 0.007 0.011 0.956
Hyderbad 11807 2 0.019 0.03 0.011 0.006 0.934 India-Andhra 10162 5 0.016 0.011 0.011 0.011 0.952
India- India-Andhra 10163 0 0.076 0.013 0.008 0.006 0.898
Hyderbad 11808 2 0.125 0.006 0.009 0.012 0.847 India-Andhra 10164 2 0.186 0.072 0.008 0.006 0.728
India- India-Andhra 10165 0 0.015 0.018 0.01 0.009 0.947
Hyderbad 11809 2 0.005 0.076 0.105 0.125 0.689 India-Andhra 10166 5 0.021 0.009 0.035 0.039 0.897
India- India-Andhra 10167 2 0.026 0.009 0.24 0.045 0.68
Hyderbad 11810 0 0.047 0.02 0.077 0.016 0.84 India-Andhra 10168 2 0.026 0.037 0.024 0.009 0.904
India- India-Andhra 10169 5 0.077 0.007 0.025 0.034 0.857
Hyderbad 11811 0 0.019 0.018 0.015 0.007 0.941 India-Andhra 10170 0 0.097 0.008 0.032 0.034 0.829
India- India-Andhra 10171 2 0.188 0.073 0.009 0.006 0.725
Hyderbad 11812 13 0.072 0.244 0.013 0.005 0.666 India-Andhra 10172 5 0.079 0.045 0.027 0.085 0.764
India- India-Andhra 10173 5 0.021 0.005 0.013 0.006 0.955
Hyderbad 11813 10 0.319 0.127 0.032 0.01 0.512 India-Andhra 10174 5 0.013 0.004 0.021 0.018 0.944
India- India-Andhra 10175 5 0.018 0.017 0.018 0.091 0.856
Hyderbad 11814 0 0.013 0.014 0.01 0.007 0.956 India-Andhra 10176 0 0.237 0.029 0.019 0.015 0.699
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5 Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
India-Andhra 10177 0 0.102 0.014 0.021 0.013 0.85 Sri Lanka 8802 2 0.005 0.035 0.007 0.522 0.43
India-Andhra 10178 5 0.02 0.025 0.011 0.014 0.93 Sri Lanka 8803 15 0.015 0.011 0.033 0.051 0.89
India-Andhra 10179 2 0.017 0.006 0.016 0.042 0.919 Thailand 11688 7 0.036 0.005 0.004 0.006 0.949
India-Andhra 10180 2 0.009 0.016 0.167 0.075 0.732 Thailand 11689 15 0.033 0.022 0.007 0.008 0.93
India-Andhra 10181 7 0.228 0.007 0.019 0.015 0.731 Thailand 11691 55 0.639 0.022 0.017 0.021 0.301
India-Kolkata 10113 7 0.019 0.013 0.018 0.019 0.931 Thailand 11698 23 0.459 0.009 0.014 0.017 0.502
India-Kolkata 10114 2 0.018 0.017 0.014 0.008 0.943 Thailand 11702 10 0.026 0.005 0.006 0.016 0.947
India-Kolkata 10115 0 0.02 0.012 0.071 0.028 0.869 Thailand 11703 13 0.084 0.008 0.005 0.007 0.896
India-Kolkata 10116 7 0.023 0.009 0.011 0.009 0.949 Thailand 11705 21 0.022 0.006 0.013 0.007 0.952
India-Kolkata 10117 5 0.359 0.043 0.087 0.018 0.494 Thailand 11707 10 0.086 0.007 0.007 0.006 0.893
India-Kolkata 10118 13 0.042 0.07 0.078 0.015 0.794 Thailand 11708 2 0.091 0.008 0.022 0.01 0.87
India-Kolkata 10119 7 0.008 0.016 0.091 0.059 0.825 Thailand 11709 15 0.049 0.006 0.012 0.01 0.923
Sri Lanka 8780 0 0.065 0.022 0.048 0.054 0.812 Thailand 11710 15 0.105 0.005 0.009 0.012 0.868
Sri Lanka 8781 5 0.022 0.023 0.106 0.1 0.75 Thailand 11711 2 0.294 0.006 0.004 0.006 0.689
Sri Lanka 8782 15 0.023 0.035 0.097 0.12 0.726 Thailand 11714 13 0.029 0.007 0.01 0.014 0.94
Sri Lanka 8783 0 0.02 0.026 0.053 0.03 0.871 Thailand 11715 21 0.108 0.013 0.006 0.015 0.858
Sri Lanka 8784 5 0.099 0.026 0.02 0.03 0.825 Thailand 11717 13 0.036 0.009 0.011 0.012 0.932
Sri Lanka 8785 7 0.025 0.162 0.09 0.107 0.616 Thailand 11718 7 0.097 0.009 0.019 0.03 0.845
Sri Lanka 8786 0 0.018 0.065 0.268 0.131 0.517 Thailand 11720 7 0.103 0.006 0.009 0.007 0.875
Sri Lanka 8787 0 0.008 0.023 0.027 0.251 0.691 Vietnam 8844 5 0.03 0.006 0.007 0.007 0.95
Sri Lanka 8788 5 0.015 0.164 0.025 0.054 0.742 Vietnam 8845 13 0.011 0.01 0.007 0.008 0.964
Sri Lanka 8789 2 0.012 0.041 0.049 0.515 0.383 Vietnam 8846 13 0.053 0.007 0.024 0.06 0.856
Sri Lanka 8790 0 0.011 0.009 0.037 0.172 0.772 Vietnam 8847 15 0.05 0.021 0.011 0.252 0.666
Sri Lanka 8791 5 0.01 0.047 0.01 0.006 0.926 Vietnam 8848 10 0.012 0.009 0.014 0.105 0.859
Sri Lanka 8792 2 0.007 0.012 0.032 0.2 0.749 Vietnam 8849 2 0.041 0.005 0.026 0.012 0.916
Sri Lanka 8793 5 0.006 0.022 0.027 0.351 0.595 Vietnam 8850 5 0.247 0.007 0.02 0.463 0.262
Sri Lanka 8794 5 0.015 0.02 0.069 0.295 0.602 Vietnam 8851 10 0.029 0.029 0.015 0.017 0.91
Sri Lanka 8795 0 0.03 0.01 0.1 0.041 0.82 Vietnam 8852 13 0.119 0.017 0.095 0.195 0.574
Sri Lanka 8796 7 0.063 0.007 0.126 0.084 0.72 Vietnam 8853 10 0.018 0.011 0.262 0.062 0.647
Sri Lanka 8797 2 0.059 0.089 0.013 0.45 0.389 Vietnam 8854 7 0.19 0.131 0.021 0.4 0.259
Sri Lanka 8798 2 0.028 0.042 0.065 0.068 0.797 Vietnam 8855 10 0.278 0.008 0.008 0.008 0.699
Sri Lanka 8799 7 0.004 0.017 0.007 0.235 0.737 Vietnam 8856 10 0.015 0.007 0.141 0.018 0.82
Sri Lanka 8800 10 0.292 0.031 0.044 0.329 0.304 Vietnam 8857 7 0.012 0.04 0.014 0.028 0.905
Sri Lanka 8801 10 0.008 0.159 0.022 0.098 0.713 Vietnam 8858 13 0.227 0.005 0.008 0.011 0.748
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Vietnam 8859 13 0.249 0.015 0.011 0.019 0.707 Japan-Oita 11967 5 0.909 0.013 0.027 0.021 0.029
Vietnam 8860 10 0.116 0.015 0.175 0.318 0.376 Japan-Oita 11968 7 0.41 0.008 0.02 0.023 0.538
Vietnam 8861 10 0.048 0.04 0.04 0.096 0.776 Japan-Oita 11969 7 0.899 0.011 0.025 0.04 0.025
Vietnam 8862 7 0.087 0.005 0.013 0.01 0.885 Japan-Oita 11970 7 0.738 0.044 0.047 0.037 0.134
Vietnam 8863 15 0.232 0.01 0.024 0.038 0.695 Japan-Oita 11971 7 0.879 0.011 0.008 0.057 0.046
Taiwan 8681 7 0.248 0.018 0.013 0.71 0.012 Japan-Oita 11972 5 0.962 0.005 0.006 0.009 0.017
Taiwan 8682 2 0.862 0.027 0.007 0.006 0.098 Japan-Oita 11973 7 0.823 0.039 0.024 0.059 0.056
Taiwan 8683 7 0.803 0.015 0.015 0.104 0.063 Japan-Oita 11974 21 0.768 0.01 0.025 0.026 0.171
Taiwan 8684 7 0.214 0.013 0.028 0.709 0.036 Japan-Oita 11975 10 0.668 0.004 0.028 0.035 0.264
Taiwan 8685 2 0.694 0.005 0.012 0.154 0.135 Japan-Oita 11976 13 0.616 0.009 0.021 0.338 0.017
Taiwan 8686 7 0.589 0.011 0.021 0.353 0.027 Japan-Oita 11977 7 0.564 0.006 0.012 0.398 0.02
Taiwan 8687 2 0.437 0.049 0.066 0.086 0.362 Japan-Oita 11979 10 0.888 0.011 0.025 0.013 0.063
Taiwan 8688 47 0.702 0.011 0.025 0.025 0.238 Japan-Oita 11980 7 0.92 0.009 0.012 0.029 0.03
Taiwan 8689 5 0.584 0.035 0.046 0.138 0.197 Japan-Oita 11981 7 0.957 0.006 0.005 0.004 0.028
Taiwan 8690 7 0.684 0.075 0.015 0.027 0.2 Japan-Oita 11982 13 0.764 0.006 0.016 0.111 0.103
Taiwan 8691 26 0.39 0.008 0.035 0.023 0.544 Japan-Oita 11985 10 0.741 0.007 0.036 0.007 0.209
Taiwan 8692 5 0.907 0.008 0.01 0.017 0.058 Japan-Oita 11986 10 0.608 0.021 0.206 0.126 0.039
Taiwan 8693 7 0.912 0.009 0.021 0.032 0.026 Japan-
Taiwan 8694 5 0.189 0.004 0.007 0.473 0.327 Kanazawa 11929 10 0.005 0.004 0.007 0.979 0.005
Taiwan 8695 2 0.854 0.009 0.073 0.036 0.029 Japan-
Taiwan 8696 23 0.037 0.005 0.013 0.929 0.015 Kanazawa 11931 10 0.828 0.01 0.01 0.069 0.083
Taiwan 8697 5 0.009 0.01 0.025 0.95 0.006 Japan-
Taiwan 8698 7 0.007 0.004 0.009 0.974 0.006 Kanazawa 11932 7 0.714 0.013 0.013 0.227 0.032
Taiwan 8699 10 0.432 0.08 0.075 0.25 0.164 Japan-
Taiwan 8700 7 0.562 0.018 0.119 0.098 0.203 Kanazawa 11933 15 0.748 0.006 0.011 0.014 0.221
Taiwan 8701 2 0.691 0.014 0.027 0.214 0.055 Japan-
Taiwan 8702 5 0.599 0.019 0.249 0.083 0.05 Kanazawa 11934 7 0.922 0.004 0.012 0.045 0.018
Taiwan 8703 7 0.009 0.005 0.02 0.959 0.006 Japan-
Taiwan 8704 2 0.733 0.017 0.036 0.076 0.139 Kanazawa 11936 7 0.903 0.006 0.015 0.021 0.056
Taiwan 8705 5 0.624 0.025 0.023 0.02 0.308 Japan-
Taiwan 8706 7 0.855 0.01 0.019 0.017 0.099 Kanazawa 11937 10 0.958 0.005 0.009 0.02 0.008
Taiwan 8707 7 0.865 0.044 0.01 0.032 0.05 Japan-
Taiwan 8708 15 0.022 0.006 0.009 0.952 0.012 Kanazawa 11939 10 0.881 0.023 0.011 0.029 0.056
Taiwan 8709 13 0.703 0.036 0.076 0.063 0.122 Japan- 11940 10 0.949 0.022 0.011 0.008 0.011
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kanazawa Sapporo
Japan- Japan-
Kanazawa 11941 10 0.925 0.031 0.02 0.011 0.013 Sapporo 11913 7 0.543 0.004 0.009 0.433 0.01
Japan- Japan-
Kanazawa 11942 7 0.875 0.008 0.018 0.009 0.091 Sapporo 11914 13 0.736 0.006 0.008 0.236 0.013
Japan- Japan-
Kanazawa 11943 28 0.634 0.065 0.056 0.06 0.186 Sapporo 11915 10 0.562 0.022 0.032 0.029 0.355
Japan- Japan-
Kanazawa 11944 39 0.019 0.014 0.027 0.92 0.02 Sapporo 11916 5 0.036 0.004 0.13 0.782 0.048
Japan- Japan-
Kanazawa 11945 10 0.855 0.011 0.01 0.048 0.077 Sapporo 11917 5 0.04 0.013 0.053 0.873 0.021
Japan- Japan-
Kanazawa 11946 10 0.954 0.006 0.015 0.013 0.013 Sapporo 11918 7 0.528 0.016 0.024 0.342 0.09
Japan-Ohmiya 11947 5 0.842 0.008 0.043 0.067 0.04 Japan-
Japan-Ohmiya 11948 10 0.691 0.039 0.149 0.105 0.016 Sapporo 11921 7 0.9 0.01 0.009 0.009 0.072
Japan-Ohmiya 11951 5 0.76 0.041 0.036 0.065 0.098 Japan-
Japan-Ohmiya 11953 7 0.94 0.006 0.015 0.015 0.024 Sapporo 11922 5 0.909 0.004 0.01 0.06 0.017
Japan-Ohmiya 11954 5 0.628 0.014 0.033 0.2 0.125 Japan-
Japan-Ohmiya 11955 7 0.523 0.006 0.032 0.194 0.246 Sapporo 11923 7 0.665 0.009 0.023 0.221 0.082
Japan-Ohmiya 11956 7 0.813 0.012 0.015 0.053 0.107 Japan-
Japan-Ohmiya 11957 2 0.7 0.027 0.056 0.204 0.013 Sapporo 11924 5 0.121 0.01 0.012 0.602 0.254
Japan-Ohmiya 11959 18 0.687 0.01 0.211 0.079 0.013 Japan-
Japan-Ohmiya 11960 2 0.924 0.023 0.007 0.015 0.031 Sapporo 11925 7 0.887 0.005 0.009 0.007 0.093
Japan-Ohmiya 11961 5 0.964 0.008 0.015 0.006 0.007 Japan-
Japan-Ohmiya 11962 13 0.839 0.013 0.011 0.013 0.124 Sapporo 11926 5 0.528 0.007 0.039 0.408 0.017
Japan-Ohmiya 11963 2 0.712 0.007 0.009 0.252 0.021 China-Henan 8869 2 0.847 0.012 0.071 0.062 0.009
Japan-Ohmiya 11964 5 0.646 0.034 0.031 0.167 0.121 China-Henan 8870 5 0.977 0.009 0.004 0.004 0.007
Japan-Ohmiya 11965 7 0.925 0.005 0.012 0.008 0.05 China-Henan 8871 5 0.81 0.158 0.014 0.008 0.01
Japan-Ohmiya 11966 2 0.8 0.014 0.025 0.111 0.05 China-Henan 8872 2 0.954 0.019 0.006 0.008 0.013
Japan- China-Henan 8873 5 0.95 0.01 0.018 0.013 0.008
Sapporo 11907 2 0.915 0.01 0.021 0.032 0.023 China-Henan 8874 5 0.91 0.043 0.014 0.005 0.029
Japan- China-Henan 8875 5 0.986 0.003 0.004 0.004 0.004
Sapporo 11909 7 0.015 0.007 0.014 0.951 0.013 China-Henan 8876 5 0.985 0.003 0.003 0.004 0.005
Japan- 11911 5 0.533 0.015 0.018 0.422 0.013 China-Henan 8877 7 0.874 0.026 0.018 0.006 0.076
Table 21 - Population clustering of each random bred Table 21 - Population clustering of each random bred individual in the database by STRs at K = 5 individual in the database by STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
China-Henan 8878 5 0.977 0.004 0.011 0.004 0.004 South Korea 7686 10 0.934 0.007 0.014 0.037 0.008
China-Henan 8879 2 0.96 0.016 0.005 0.004 0.016 South Korea 7687 10 0.699 0.005 0.03 0.068 0.197
China-Henan 8880 7 0.954 0.022 0.007 0.009 0.008 South Korea 7688 2 0.362 0.005 0.032 0.538 0.063
China-Henan 8881 5 0.88 0.049 0.058 0.005 0.009 South Korea 7689 10 0.966 0.007 0.008 0.011 0.009
China-Henan 8882 5 0.872 0.012 0.027 0.031 0.057 South Korea 7690 10 0.928 0.004 0.014 0.01 0.044
China-Henan 8883 2 0.973 0.006 0.008 0.005 0.007 South Korea 7691 7 0.945 0.01 0.015 0.014 0.016
China-Henan 8884 2 0.892 0.029 0.011 0.003 0.065 South Korea 7692 5 0.88 0.016 0.029 0.014 0.061
China-Henan 8885 2 0.971 0.005 0.008 0.008 0.008 South Korea 7693 2 0.739 0.017 0.118 0.086 0.04
China-Henan 8886 2 0.969 0.008 0.012 0.005 0.006 South Korea 7694 5 0.981 0.003 0.005 0.004 0.006
China-Henan 8887 2 0.872 0.071 0.029 0.021 0.007 South Korea 7695 7 0.784 0.011 0.125 0.066 0.014
China-Henan 8888 2 0.936 0.027 0.012 0.014 0.011 South Korea 7696 5 0.974 0.009 0.006 0.006 0.005
South Korea 2769 5 0.981 0.004 0.005 0.005 0.005 South Korea 7697 10 0.95 0.019 0.008 0.01 0.013
South Korea 2772 47 0.958 0.01 0.008 0.006 0.018 South Korea 7698 23 0.64 0.04 0.085 0.033 0.202
South Korea 2775 13 0.964 0.007 0.01 0.011 0.008 South Korea 7699 7 0.945 0.015 0.018 0.008 0.014
South Korea 2776 13 0.825 0.006 0.056 0.042 0.072 South Korea 7700 7 0.886 0.026 0.027 0.012 0.049
South Korea 2779 2 0.96 0.01 0.006 0.006 0.018
South Korea 2784 2 0.98 0.006 0.004 0.004 0.006
South Korea 2785 2 0.863 0.096 0.018 0.015 0.009
South Korea 2786 2 0.976 0.003 0.006 0.011 0.005
South Korea 7671 2 0.965 0.006 0.012 0.009 0.008
South Korea 7672 2 0.957 0.005 0.008 0.01 0.02
South Korea 7673 2 0.93 0.028 0.026 0.011 0.005
South Korea 7674 2 0.901 0.01 0.032 0.046 0.011
South Korea 7675 10 0.965 0.005 0.012 0.011 0.007
South Korea 7676 7 0.947 0.018 0.011 0.013 0.011
South Korea 7677 15 0.385 0.29 0.056 0.259 0.01
South Korea 7678 2 0.952 0.011 0.013 0.018 0.006
South Korea 7679 5 0.974 0.007 0.007 0.006 0.005
South Korea 7680 7 0.924 0.007 0.03 0.03 0.009
South Korea 7681 13 0.736 0.016 0.224 0.016 0.007
South Korea 7682 5 0.955 0.005 0.021 0.009 0.01
South Korea 7683 7 0.976 0.006 0.005 0.005 0.009
South Korea 7684 7 0.588 0.012 0.316 0.041 0.043
South Korea 7685 18 0.941 0.006 0.011 0.019 0.022
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
USA-NY 2547 1 0.008 0.079 0.08 0.823 0.011 Brazil 7964 2 0.009 0.009 0.012 0.965 0.006
USA-NY 2559 3 0.008 0.011 0.315 0.663 0.003 Brazil 7965 27 0.007 0.006 0.005 0.978 0.005
USA-NY 2568 0 0.004 0.004 0.004 0.986 0.002 Brazil 7966 2 0.004 0.011 0.018 0.955 0.012
USA-NY 2569 5 0.01 0.007 0.011 0.96 0.013 Brazil 7968 23 0.016 0.009 0.017 0.949 0.009
USA-NY 2572 1 0.008 0.024 0.017 0.945 0.006 Brazil 7969 1 0.003 0.004 0.005 0.985 0.003
USA-NY 2578 17 0.005 0.034 0.018 0.928 0.015 Brazil 7970 1 0.006 0.007 0.007 0.977 0.004
USA-NY 2590 1 0.006 0.008 0.028 0.956 0.002 Brazil 7971 1 0.007 0.004 0.006 0.979 0.005
USA-NY 2591 2 0.008 0.007 0.011 0.964 0.01 Brazil 7972 1 0.004 0.005 0.012 0.973 0.006
USA-NY 2597 4 0.015 0.036 0.018 0.897 0.035 Brazil 7973 0 0.012 0.004 0.009 0.97 0.005
USA-MS 9971 3 0.017 0.041 0.012 0.921 0.01 Brazil 7974 3 0.008 0.008 0.018 0.961 0.006
USA-MS 9972 2 0.011 0.119 0.026 0.822 0.023 Brazil 7975 5 0.013 0.01 0.013 0.96 0.005
USA-MS 9974 2 0.028 0.047 0.019 0.897 0.009 Brazil 7976 1 0.007 0.004 0.006 0.979 0.004
USA-MS 9977 5 0.015 0.005 0.011 0.962 0.007 Brazil 7977 2 0.006 0.004 0.02 0.968 0.003
USA-MS 9980 2 0.01 0.027 0.027 0.923 0.013 Brazil 7978 1 0.014 0.03 0.012 0.938 0.006
USA-MS 9983 2 0.007 0.012 0.009 0.961 0.011 Brazil 7979 2 0.023 0.011 0.014 0.946 0.006
USA-MS 9985 3 0.171 0.012 0.031 0.783 0.004 Brazil 7980 2 0.013 0.025 0.291 0.656 0.015
USA-MS 9987 3 0.054 0.028 0.065 0.841 0.012 Brazil 7981 2 0.157 0.008 0.013 0.818 0.004
USA-MS 9989 2 0.023 0.012 0.013 0.947 0.004 Brazil 7982 20 0.077 0.116 0.024 0.775 0.008
USA-MS 9992 3 0.016 0.012 0.133 0.826 0.012 Brazil 7983 4 0.02 0.148 0.052 0.768 0.012
USA-HI 5366 3 0.201 0.044 0.026 0.726 0.004 Brazil 7984 15 0.344 0.009 0.027 0.614 0.006
USA-HI 5367 1 0.061 0.122 0.028 0.765 0.024 Brazil 7985 5 0.014 0.019 0.021 0.942 0.005
USA-HI 5371 1 0.032 0.028 0.207 0.711 0.022 Brazil 7986 3 0.088 0.012 0.038 0.857 0.005
USA-HI 5372 2 0.019 0.193 0.099 0.674 0.016 Brazil 7987 2 0.013 0.034 0.038 0.911 0.004
USA-HI 5379 1 0.035 0.009 0.047 0.889 0.021 Brazil 7988 0 0.118 0.035 0.029 0.809 0.009
USA-HI 5380 1 0.007 0.004 0.017 0.969 0.003 Brazil 7989 1 0.151 0.1 0.013 0.73 0.006
USA-HI 5383 3 0.032 0.111 0.111 0.465 0.28 Brazil 7990 1 0.019 0.022 0.008 0.947 0.004
USA-HI 5384 5 0.003 0.011 0.097 0.88 0.008 Finland 8077 11 0.003 0.005 0.012 0.973 0.007
USA-HI 5401 2 0.037 0.025 0.05 0.883 0.005 Finland 8084 11 0.023 0.024 0.034 0.905 0.013
USA-HI 5402 2 0.128 0.01 0.028 0.81 0.023 Finland 8086 5 0.007 0.009 0.058 0.918 0.008
Brazil 7961 1 0.009 0.005 0.021 0.961 0.004 Finland 8089 8 0.019 0.104 0.018 0.827 0.032
Brazil 7962 2 0.008 0.012 0.092 0.885 0.003 Finland 8093 16 0.005 0.005 0.204 0.78 0.006
Brazil 7963 17 0.091 0.164 0.022 0.72 0.004 Finland 8094 9 0.011 0.017 0.058 0.835 0.079
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Finland 8096 7 0.003 0.004 0.021 0.959 0.014 Germany 8747 13 0.004 0.006 0.006 0.982 0.003
Finland 8107 24 0.002 0.004 0.005 0.986 0.003 Germany 8749 2 0.003 0.003 0.005 0.984 0.005
Finland 8110 10 0.005 0.029 0.042 0.915 0.008 Italy-Milan 8050 1 0.105 0.012 0.095 0.673 0.115
Finland 8116 16 0.016 0.03 0.013 0.93 0.01 Italy-Milan 8057 2 0.051 0.1 0.207 0.578 0.064
Finland 8120 21 0.012 0.004 0.025 0.954 0.005 Italy-Milan 8060 1 0.016 0.045 0.21 0.707 0.022
Germany 8711 4 0.004 0.003 0.008 0.981 0.004 Italy-Milan 8061 2 0.104 0.028 0.295 0.552 0.022
Germany 8712 3 0.006 0.013 0.006 0.955 0.02 Italy-Milan 8062 3 0.007 0.012 0.583 0.392 0.006
Germany 8713 3 0.025 0.02 0.062 0.869 0.023 Italy-Milan 8065 5 0.005 0.008 0.488 0.493 0.005
Germany 8714 2 0.008 0.01 0.026 0.928 0.028 Italy-Milan 8066 1 0.029 0.058 0.107 0.786 0.021
Germany 8715 4 0.003 0.004 0.012 0.974 0.007 Italy-Milan 8067 2 0.008 0.016 0.467 0.492 0.017
Germany 8716 3 0.005 0.005 0.009 0.975 0.005 Italy-Milan 8068 2 0.008 0.013 0.509 0.465 0.006
Germany 8717 11 0.005 0.005 0.009 0.975 0.006 Italy-Milan 8069 1 0.033 0.129 0.201 0.614 0.023
Germany 8720 3 0.49 0.093 0.015 0.396 0.005 Italy-Milan 8071 3 0.015 0.013 0.04 0.923 0.01
Germany 8721 10 0.004 0.005 0.039 0.944 0.007 Italy-Milan 8072 3 0.272 0.015 0.201 0.501 0.011
Germany 8727 1 0.005 0.01 0.027 0.954 0.004 Italy-Milan 8073 1 0.013 0.009 0.263 0.694 0.02
Germany 8728 10 0.004 0.009 0.006 0.977 0.004 Italy-Milan 8074 2 0.184 0.061 0.025 0.726 0.003
Germany 8729 2 0.002 0.003 0.005 0.987 0.002 Italy-Rome 8586 1 0.014 0.021 0.475 0.478 0.011
Germany 8730 22 0.028 0.016 0.052 0.9 0.004 Italy-Rome 8589 3 0.039 0.015 0.092 0.848 0.005
Germany 8731 12 0.003 0.005 0.007 0.981 0.003 Italy-Rome 8592 2 0.013 0.018 0.14 0.626 0.202
Germany 8732 4 0.003 0.01 0.013 0.971 0.003 Italy-Rome 8594 1 0.02 0.02 0.112 0.808 0.039
Germany 8733 16 0.021 0.014 0.013 0.938 0.015 Italy-Rome 8595 1 0.042 0.044 0.188 0.606 0.12
Germany 8734 1 0.002 0.003 0.009 0.984 0.002 Italy-Rome 8596 1 0.011 0.01 0.542 0.43 0.007
Germany 8735 2 0.007 0.004 0.009 0.977 0.004 Italy-Rome 8597 1 0.034 0.012 0.188 0.73 0.036
Germany 8736 1 0.006 0.006 0.031 0.939 0.018 Italy-Rome 8599 1 0.053 0.007 0.077 0.858 0.005
Germany 8737 3 0.007 0.013 0.016 0.95 0.013 Italy-Rome 8601 2 0.037 0.014 0.081 0.701 0.167
Germany 8738 10 0.004 0.007 0.049 0.864 0.076 Italy-Rome 8602 3 0.01 0.023 0.26 0.694 0.013
Germany 8739 2 0.003 0.005 0.011 0.978 0.003 Italy-Rome 8603 1 0.012 0.01 0.044 0.915 0.019
Germany 8741 11 0.004 0.006 0.019 0.967 0.004 Italy-Rome 8604 3 0.207 0.011 0.118 0.645 0.019
Germany 8742 9 0.006 0.004 0.008 0.979 0.003 Italy-Rome 8609 2 0.007 0.006 0.364 0.616 0.007
Germany 8744 6 0.094 0.013 0.316 0.572 0.006 Italy-Rome 8610 2 0.01 0.011 0.4 0.572 0.007
Germany 8745 23 0.004 0.009 0.027 0.953 0.007 Italy-Rome 8611 2 0.007 0.01 0.295 0.648 0.04
Germany 8746 1 0.004 0.01 0.007 0.975 0.004 Turkey 6477 6 0.004 0.003 0.856 0.109 0.028
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Turkey 6478 12 0.01 0.011 0.922 0.017 0.041 Turkey 6738 3 0.003 0.005 0.848 0.138 0.006
Turkey 6480 10 0.006 0.018 0.922 0.048 0.006 Turkey 6739 4 0.006 0.038 0.506 0.403 0.047
Turkey 6481 11 0.587 0.356 0.032 0.019 0.005 Turkey 6740 1 0.002 0.004 0.003 0.988 0.003
Turkey 6482 12 0.014 0.02 0.698 0.259 0.01 Turkey 6741 2 0.858 0.064 0.015 0.059 0.004
Turkey 6484 6 0.007 0.015 0.88 0.093 0.005 Turkey 6742 4 0.026 0.054 0.677 0.189 0.055
Turkey 6486 8 0.006 0.026 0.648 0.305 0.016 Turkey 6743 2 0.006 0.012 0.664 0.308 0.009
Turkey 6487 13 0.006 0.005 0.886 0.095 0.007 Turkey 6745 1 0.013 0.007 0.56 0.403 0.018
Turkey 6488 11 0.013 0.009 0.838 0.097 0.044 Turkey 6746 2 0.324 0.218 0.056 0.346 0.055
Turkey 6491 15 0.691 0.088 0.044 0.167 0.01 Turkey 6748 3 0.011 0.077 0.815 0.08 0.017
Turkey 6494 10 0.032 0.018 0.494 0.382 0.074 Turkey 6749 2 0.018 0.006 0.434 0.51 0.031
Turkey 6496 11 0.027 0.063 0.787 0.114 0.009 Turkey 6750 3 0.004 0.006 0.503 0.484 0.003
Turkey 6499 11 0.01 0.011 0.444 0.527 0.009 Turkey 6753 2 0.021 0.014 0.626 0.277 0.062
Turkey 6500 15 0.004 0.005 0.889 0.096 0.005 Turkey 6754 3 0.004 0.006 0.508 0.283 0.198
Turkey 6502 6 0.021 0.014 0.861 0.095 0.009 Turkey 6755 3 0.009 0.005 0.727 0.248 0.012
Turkey 6503 3 0.013 0.007 0.691 0.278 0.01 Turkey 6756 2 0.003 0.006 0.629 0.356 0.006
Turkey 6507 12 0.01 0.004 0.939 0.041 0.006 Turkey 6758 3 0.041 0.018 0.796 0.124 0.02
Turkey 6510 9 0.04 0.011 0.515 0.429 0.005 Turkey 6759 4 0.007 0.023 0.73 0.235 0.005
Turkey 6512 13 0.015 0.019 0.887 0.044 0.035 Turkey 6760 2 0.005 0.017 0.385 0.577 0.017
Turkey 6513 12 0.007 0.058 0.628 0.277 0.03 Cyprus 10128 3 0.031 0.013 0.907 0.041 0.008
Turkey 6514 8 0.951 0.018 0.011 0.008 0.013 Cyprus 10129 1 0.007 0.009 0.514 0.455 0.014
Turkey 6516 10 0.003 0.008 0.008 0.976 0.006 Cyprus 10130 3 0.004 0.012 0.866 0.114 0.004
Turkey 6519 6 0.01 0.016 0.519 0.439 0.017 Cyprus 10131 1 0.084 0.078 0.776 0.051 0.012
Turkey 6520 13 0.006 0.007 0.536 0.444 0.006 Cyprus 10132 0 0.017 0.031 0.924 0.007 0.02
Turkey 6521 11 0.017 0.012 0.579 0.381 0.012 Cyprus 10133 3 0.013 0.018 0.853 0.101 0.015
Turkey 6729 2 0.036 0.079 0.306 0.067 0.512 Cyprus 10134 1 0.005 0.041 0.915 0.027 0.013
Turkey 6730 2 0.006 0.005 0.788 0.197 0.004 Cyprus 10135 2 0.011 0.17 0.755 0.059 0.006
Turkey 6731 3 0.005 0.014 0.549 0.397 0.035 Cyprus 10136 3 0.009 0.015 0.542 0.332 0.102
Turkey 6732 2 0.086 0.116 0.656 0.055 0.087 Cyprus 10137 1 0.01 0.005 0.86 0.026 0.099
Turkey 6733 4 0.028 0.023 0.879 0.059 0.012 Cyprus 10138 2 0.01 0.015 0.953 0.007 0.015
Turkey 6734 1 0.023 0.012 0.906 0.047 0.013 Cyprus 10139 3 0.088 0.095 0.773 0.015 0.03
Turkey 6735 3 0.003 0.003 0.977 0.009 0.007 Cyprus 10140 0 0.008 0.011 0.914 0.057 0.011
Turkey 6736 1 0.004 0.011 0.765 0.21 0.01 Cyprus 10141 1 0.007 0.008 0.908 0.07 0.007
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Cyprus 10142 1 0.017 0.031 0.917 0.01 0.025 Lebanon 10251 3 0.005 0.03 0.929 0.023 0.012
Cyprus 10143 1 0.007 0.005 0.973 0.007 0.008 Lebanon 10252 12 0.014 0.016 0.385 0.332 0.254
Cyprus 10144 3 0.01 0.099 0.867 0.014 0.01 Lebanon 10253 6 0.015 0.013 0.89 0.02 0.063
Cyprus 10145 2 0.005 0.005 0.922 0.061 0.007 Lebanon 10254 13 0.032 0.021 0.919 0.012 0.016
Cyprus 10146 0 0.007 0.045 0.923 0.008 0.017 Lebanon 10255 7 0.027 0.009 0.699 0.062 0.203
Cyprus 10147 2 0.004 0.006 0.875 0.111 0.004 Lebanon 10256 12 0.008 0.007 0.958 0.011 0.016
Cyprus 10148 1 0.02 0.046 0.894 0.02 0.02 Lebanon 10257 3 0.078 0.046 0.83 0.027 0.02
Cyprus 10149 3 0.012 0.028 0.789 0.061 0.111 Lebanon 10258 17 0.018 0.029 0.917 0.008 0.028
Cyprus 10150 1 0.014 0.008 0.913 0.051 0.014 Lebanon 10259 2 0.547 0.087 0.328 0.032 0.007
Cyprus 10151 2 0.013 0.02 0.935 0.012 0.019 Lebanon 10260 14 0.008 0.008 0.957 0.015 0.012
Cyprus 10152 2 0.011 0.008 0.865 0.094 0.021 Lebanon 10261 13 0.029 0.012 0.909 0.017 0.032
Cyprus 10153 1 0.023 0.007 0.931 0.016 0.022 Lebanon 10262 18 0.025 0.014 0.875 0.017 0.069
Cyprus 10154 1 0.01 0.109 0.823 0.018 0.04 Lebanon 10263 3 0.009 0.015 0.946 0.014 0.017
Cyprus 10155 3 0.011 0.126 0.85 0.009 0.004 Lebanon 10264 3 0.032 0.052 0.773 0.119 0.024
Cyprus 10156 5 0.038 0.012 0.907 0.016 0.027 Lebanon 10265 9 0.006 0.007 0.927 0.01 0.049
Cyprus 10157 2 0.006 0.008 0.859 0.012 0.117 Lebanon 10266 4 0.018 0.077 0.886 0.01 0.008
Lebanon 10235 19 0.08 0.068 0.789 0.023 0.039 Lebanon 10267 13 0.004 0.006 0.54 0.439 0.01
Lebanon 10236 22 0.033 0.101 0.842 0.01 0.015 Lebanon 10268 15 0.07 0.011 0.897 0.017 0.005
Lebanon 10237 16 0.177 0.192 0.604 0.018 0.009 Lebanon 10270 10 0.315 0.025 0.591 0.038 0.031
Lebanon 10238 3 0.015 0.038 0.842 0.054 0.05 Lebanon 10271 4 0.041 0.271 0.514 0.057 0.117
Lebanon 10239 14 0.007 0.009 0.962 0.012 0.01 Lebanon 10273 5 0.173 0.018 0.67 0.1 0.039
Lebanon 10240 19 0.029 0.062 0.835 0.04 0.035 Lebanon 10274 5 0.057 0.082 0.801 0.054 0.005
Lebanon 10241 6 0.128 0.044 0.688 0.068 0.072 Lebanon 10276 5 0.004 0.012 0.957 0.01 0.016
Lebanon 10242 2 0.014 0.015 0.852 0.1 0.02 Lebanon 10277 4 0.174 0.011 0.677 0.113 0.025
Lebanon 10243 3 0.04 0.039 0.819 0.027 0.075 Lebanon 10278 5 0.016 0.017 0.914 0.01 0.043
Lebanon 10244 15 0.026 0.05 0.861 0.011 0.051 Lebanon 10279 1 0.008 0.104 0.787 0.013 0.088
Lebanon 10245 7 0.007 0.039 0.713 0.024 0.217 Lebanon 10280 2 0.033 0.244 0.681 0.019 0.023
Lebanon 10246 15 0.008 0.014 0.911 0.022 0.045 Lebanon 10281 8 0.007 0.008 0.954 0.013 0.019
Lebanon 10247 24 0.011 0.012 0.727 0.005 0.245 Lebanon 10282 3 0.039 0.015 0.921 0.01 0.015
Lebanon 10248 19 0.012 0.02 0.916 0.042 0.01 Lebanon 10283 18 0.005 0.037 0.943 0.007 0.009
Lebanon 10249 17 0.014 0.051 0.339 0.587 0.009 Lebanon 10284 16 0.046 0.061 0.693 0.03 0.169
Lebanon 10250 22 0.011 0.009 0.841 0.041 0.097 Lebanon 10285 1 0.021 0.028 0.92 0.016 0.015
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Lebanon 10286 5 0.166 0.053 0.583 0.02 0.178 Israel 4982 4 0.012 0.079 0.817 0.083 0.009
Lebanon 10287 2 0.043 0.039 0.519 0.334 0.065 Israel 4983 1 0.333 0.021 0.081 0.518 0.046
Lebanon 10288 22 0.042 0.01 0.087 0.856 0.006 Israel 4984 2 0.24 0.028 0.024 0.679 0.028
Lebanon 10289 4 0.009 0.024 0.922 0.007 0.038 Israel 4985 17 0.034 0.016 0.904 0.038 0.008
Lebanon 10290 3 0.071 0.167 0.722 0.008 0.032 Israel 4986 2 0.019 0.016 0.933 0.015 0.017
Lebanon 10291 9 0.038 0.13 0.71 0.016 0.107 Israel 4988 3 0.042 0.026 0.89 0.026 0.016
Lebanon 10292 7 0.017 0.401 0.528 0.027 0.028 Israel 4989 4 0.102 0.019 0.834 0.013 0.032
Lebanon 10294 8 0.105 0.018 0.835 0.022 0.02 Israel 4990 2 0.291 0.014 0.671 0.018 0.007
Lebanon 10295 6 0.057 0.053 0.771 0.033 0.087 Israel 4992 6 0.007 0.009 0.9 0.068 0.016
Lebanon 10297 5 0.018 0.014 0.729 0.021 0.217 Israel 4993 9 0.007 0.011 0.958 0.013 0.011
Lebanon 10298 8 0.014 0.071 0.687 0.008 0.22 Israel 4994 2 0.003 0.005 0.981 0.006 0.005
Lebanon 10299 17 0.054 0.07 0.488 0.276 0.111 Israel 4995 2 0.191 0.01 0.763 0.018 0.018
Lebanon 10300 20 0.021 0.024 0.866 0.012 0.078 Israel 4996 1 0.026 0.004 0.938 0.009 0.022
Israel 4962 1 0.006 0.042 0.7 0.067 0.184 Israel 4997 3 0.106 0.011 0.812 0.011 0.06
Israel 4963 1 0.017 0.039 0.898 0.029 0.017 Israel 4998 2 0.014 0.034 0.603 0.222 0.127
Israel 4964 2 0.013 0.014 0.841 0.059 0.073 Israel 5000 2 0.04 0.016 0.917 0.008 0.018
Israel 4966 2 0.008 0.036 0.929 0.021 0.006 Israel 5001 2 0.012 0.022 0.679 0.272 0.015
Israel 4967 2 0.029 0.064 0.57 0.285 0.053 Israel 5002 2 0.022 0.036 0.891 0.047 0.005
Israel 4968 3 0.027 0.017 0.91 0.012 0.035 Israel 5003 2 0.11 0.025 0.643 0.185 0.038
Israel 4969 1 0.222 0.024 0.142 0.594 0.018 Israel 5004 3 0.114 0.059 0.711 0.057 0.059
Israel 4970 1 0.023 0.017 0.814 0.115 0.03 Israel 5005 2 0.006 0.016 0.806 0.161 0.011
Israel 4971 1 0.018 0.007 0.918 0.014 0.043 Israel 5006 3 0.005 0.008 0.925 0.036 0.026
Israel 4972 2 0.036 0.018 0.853 0.069 0.024 Israel 5007 2 0.257 0.026 0.632 0.079 0.005
Israel 4973 2 0.01 0.02 0.947 0.014 0.009 Israel 5008 1 0.022 0.024 0.88 0.047 0.026
Israel 4974 2 0.009 0.016 0.919 0.03 0.026 Israel 5009 3 0.217 0.02 0.649 0.038 0.076
Israel 4975 1 0.007 0.009 0.884 0.087 0.013 Israel 5010 4 0.004 0.007 0.955 0.026 0.009
Israel 4976 1 0.015 0.049 0.735 0.152 0.049 Israel 5011 2 0.017 0.009 0.933 0.017 0.023
Israel 4977 3 0.007 0.018 0.559 0.327 0.09 Egypt-Cairo 8190 3 0.015 0.017 0.916 0.043 0.01
Israel 4978 3 0.028 0.041 0.75 0.046 0.135 Egypt-Cairo 8192 5 0.007 0.072 0.746 0.148 0.026
Israel 4979 2 0.014 0.008 0.868 0.023 0.088 Egypt-Cairo 8193 4 0.007 0.018 0.936 0.023 0.017
Israel 4980 1 0.035 0.088 0.66 0.131 0.085 Egypt-Cairo 8196 4 0.04 0.071 0.863 0.009 0.017
Israel 4981 5 0.311 0.008 0.624 0.011 0.045 Egypt-Cairo 8203 4 0.009 0.006 0.965 0.013 0.006
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Cairo 8215 3 0.008 0.012 0.961 0.009 0.01 Egypt-Cairo 9952 4 0.006 0.018 0.942 0.009 0.024
Egypt-Cairo 8198 3 0.015 0.015 0.938 0.022 0.01 Egypt-Cairo 9953 8 0.013 0.013 0.319 0.535 0.12
Egypt-Cairo 8194 1 0.019 0.019 0.869 0.076 0.017 Egypt-Cairo 9954 1 0.324 0.014 0.651 0.007 0.004
Egypt-Cairo 8211 9 0.005 0.004 0.971 0.009 0.01 Egypt-Cairo 9955 2 0.032 0.18 0.376 0.404 0.008
Egypt-Cairo 8216 2 0.01 0.012 0.9 0.071 0.007 Egypt-Cairo 9956 8 0.171 0.018 0.789 0.011 0.01
Egypt-Cairo 8195 2 0.009 0.052 0.909 0.02 0.01 Egypt-Cairo 9957 2 0.066 0.012 0.875 0.027 0.019
Egypt-Cairo 8199 8 0.005 0.045 0.937 0.007 0.007 Egypt-Cairo 9958 4 0.053 0.015 0.914 0.012 0.006
Egypt-Cairo 8200 13 0.006 0.005 0.942 0.032 0.015 Egypt-Cairo 9959 2 0.036 0.339 0.553 0.05 0.021
Egypt-Cairo 8201 1 0.026 0.063 0.786 0.037 0.087 Egypt-Cairo 9960 1 0.023 0.007 0.924 0.013 0.033
Egypt-Cairo 8202 2 0.614 0.27 0.066 0.019 0.032 Egypt-Cairo 9961 5 0.529 0.059 0.384 0.022 0.006
Egypt-Cairo 8204 2 0.012 0.011 0.965 0.009 0.004 Egypt-Cairo 9962 3 0.009 0.033 0.914 0.031 0.013
Egypt-Cairo 8208 1 0.015 0.024 0.929 0.009 0.023 Egypt-Cairo 9963 3 0.015 0.007 0.954 0.014 0.009
Egypt-Cairo 8210 3 0.009 0.053 0.885 0.008 0.045 Egypt-Cairo 9964 1 0.034 0.047 0.892 0.019 0.008
Egypt-Cairo 8214 2 0.007 0.007 0.971 0.006 0.01 Egypt-Cairo 10021 6 0.003 0.007 0.979 0.006 0.006
Egypt-Cairo 8191 2 0.028 0.014 0.91 0.02 0.028 Egypt-Cairo 10022 1 0.011 0.013 0.962 0.008 0.006
Egypt-Cairo 8197 1 0.005 0.041 0.938 0.007 0.008 Egypt-Cairo 10023 0 0.005 0.011 0.975 0.004 0.005
Egypt-Cairo 8205 1 0.019 0.027 0.922 0.01 0.021 Egypt-Cairo 10024 1 0.004 0.003 0.978 0.012 0.003
Egypt-Cairo 8206 1 0.022 0.018 0.945 0.007 0.008 Egypt-Cairo 10025 2 0.007 0.012 0.924 0.037 0.019
Egypt-Cairo 8207 2 0.035 0.026 0.92 0.009 0.01 Egypt-Cairo 10026 17 0.022 0.006 0.941 0.026 0.005
Egypt-Cairo 8209 1 0.005 0.004 0.971 0.011 0.008 Egypt-Cairo 10027 1 0.009 0.086 0.879 0.018 0.009
Egypt-Cairo 8212 1 0.006 0.007 0.97 0.007 0.009 Egypt-Cairo 10028 1 0.007 0.008 0.964 0.007 0.013
Egypt-Cairo 8213 1 0.005 0.009 0.967 0.009 0.009 Egypt-Cairo 10029 3 0.004 0.005 0.973 0.005 0.013
Egypt-Cairo 9942 2 0.033 0.011 0.817 0.008 0.132 Egypt-Cairo 10030 1 0.009 0.005 0.971 0.01 0.005
Egypt-Cairo 9943 3 0.47 0.055 0.058 0.404 0.013 Egypt-Cairo 10031 3 0.004 0.006 0.98 0.003 0.007
Egypt-Cairo 9944 4 0.006 0.017 0.521 0.341 0.116 Egypt-Cairo 10032 0 0.004 0.006 0.964 0.005 0.021
Egypt-Cairo 9945 0 0.007 0.031 0.928 0.014 0.019 Egypt-Cairo 10033 1 0.006 0.01 0.975 0.004 0.006
Egypt-Cairo 9946 3 0.06 0.034 0.883 0.011 0.012 Egypt-Cairo 10034 1 0.005 0.01 0.97 0.009 0.005
Egypt-Cairo 9947 3 0.008 0.028 0.909 0.008 0.048 Egypt-Cairo 10035 3 0.067 0.059 0.848 0.008 0.019
Egypt-Cairo 9948 0 0.012 0.006 0.882 0.095 0.005 Egypt-Cairo 10037 5 0.006 0.035 0.731 0.219 0.008
Egypt-Cairo 9949 0 0.032 0.016 0.925 0.019 0.008 Egypt-Cairo 10042 1 0.03 0.055 0.85 0.051 0.013
Egypt-Cairo 9950 1 0.006 0.013 0.932 0.043 0.006 Egypt-Cairo 10043 2 0.004 0.014 0.935 0.037 0.01
Egypt-Cairo 9951 2 0.012 0.013 0.961 0.01 0.005 Egypt-Cairo 10044 4 0.012 0.008 0.964 0.01 0.005
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Egypt-Cairo 10045 1 0.008 0.01 0.951 0.026 0.005 Egypt- Luxor 10057 12 0.009 0.01 0.949 0.01 0.021
Egypt-Cairo 10046 0 0.022 0.015 0.946 0.01 0.007 Egypt- Luxor 10058 6 0.006 0.006 0.973 0.008 0.007
Egypt-Cairo 10047 0 0.009 0.014 0.954 0.007 0.016 Egypt- Luxor 10060 4 0.005 0.008 0.959 0.022 0.005
Egypt-Cairo 10048 1 0.049 0.017 0.918 0.012 0.003 Egypt- Luxor 10061 0 0.254 0.012 0.714 0.016 0.005
Egypt-Cairo 10083 24 0.013 0.008 0.936 0.037 0.007 Egypt- Luxor 10062 3 0.007 0.01 0.947 0.026 0.01
Egypt-Cairo 10040 2 0.017 0.025 0.912 0.035 0.011 Egypt- Luxor 10063 1 0.051 0.098 0.735 0.056 0.061
Egypt-Cairo 10041 1 0.015 0.054 0.904 0.018 0.01 Egypt- Luxor 10064 1 0.007 0.068 0.893 0.027 0.005
Egypt-Cairo 10049 9 0.019 0.055 0.901 0.012 0.013 Egypt- Luxor 10065 0 0.01 0.122 0.835 0.014 0.018
Egypt-Cairo 10084 7 0.019 0.021 0.923 0.03 0.007 Egypt- Luxor 10066 3 0.028 0.066 0.859 0.039 0.008
Egypt-Cairo 10085 19 0.007 0.03 0.89 0.068 0.004 Egypt- Luxor 10067 4 0.004 0.01 0.967 0.005 0.014
Egypt-Cairo 10087 4 0.004 0.008 0.976 0.009 0.003 Egypt- Luxor 10068 7 0.044 0.031 0.905 0.017 0.003
Egypt-Cairo 10090 4 0.021 0.107 0.84 0.023 0.009 Egypt- Luxor 10069 3 0.005 0.011 0.964 0.006 0.014
Egypt-Cairo 9968 0 0.007 0.02 0.936 0.019 0.018 Egypt- Luxor 10070 1 0.244 0.013 0.718 0.021 0.004
Egypt-Asuit 10091 1 0.004 0.007 0.974 0.01 0.005 Egypt- Luxor 10071 3 0.015 0.027 0.935 0.006 0.016
Egypt-Asuit 10093 3 0.003 0.012 0.964 0.018 0.003 Egypt- Luxor 10072 2 0.013 0.009 0.963 0.007 0.008
Egypt-Asuit 10094 4 0.005 0.015 0.961 0.014 0.004 Egypt- Luxor 10073 1 0.005 0.009 0.016 0.964 0.006
Egypt-Asuit 10095 13 0.005 0.02 0.939 0.032 0.004 Egypt- Luxor 10074 0 0.003 0.004 0.983 0.006 0.004
Egypt-Asuit 10096 1 0.012 0.01 0.967 0.008 0.003 Egypt- Luxor 10079 4 0.006 0.056 0.864 0.068 0.007
Egypt-Asuit 10098 1 0.003 0.006 0.98 0.009 0.003 Egypt- Luxor 10080 5 0.014 0.212 0.752 0.016 0.006
Egypt-Asuit 10099 1 0.004 0.008 0.979 0.006 0.004 Egypt-Abu
Egypt-Asuit 10100 2 0.082 0.107 0.694 0.097 0.02 Simbel 10076 10 0.039 0.028 0.904 0.023 0.007
Egypt-Asuit 10101 2 0.009 0.026 0.949 0.006 0.01 Egypt-Abu
Egypt-Asuit 10102 1 0.023 0.022 0.94 0.005 0.01 Simbel 10077 17 0.01 0.024 0.954 0.006 0.006
Egypt-Luxor 10038 1 0.076 0.029 0.884 0.006 0.004 Egypt-Abu
Egypt-Luxor 10039 5 0.004 0.005 0.967 0.004 0.021 Simbel 10081 17 0.011 0.022 0.944 0.013 0.009
Egypt-Luxor 10050 2 0.032 0.017 0.936 0.005 0.01 Egypt-Abu
Egypt-Luxor 10051 1 0.005 0.008 0.979 0.005 0.004 Simbel 10089 1 0.004 0.009 0.919 0.065 0.003
Egypt-Luxor 10052 11 0.022 0.053 0.908 0.011 0.005 Egypt-Abu
Egypt-Luxor 10053 2 0.013 0.042 0.827 0.007 0.111 Simbel 10092 2 0.005 0.006 0.979 0.005 0.005
Egypt-Luxor 10054 2 0.016 0.008 0.955 0.007 0.015 Iraq-West 9587 9 0.012 0.039 0.25 0.046 0.653
Egypt-Luxor 10055 1 0.012 0.012 0.963 0.005 0.007 Iraq-West 10202 6 0.007 0.006 0.331 0.023 0.634
Egypt-Luxor 10056 2 0.026 0.014 0.93 0.012 0.018 Iraq-West 10204 15 0.004 0.011 0.277 0.048 0.661
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5 raq-West 11854 18 0.03 0.014 0.14 0.012 0.804 Iraq-Baghdad 11878 3 0.006 0.01 0.307 0.071 0.605 raq-West 11860 10 0.012 0.034 0.052 0.009 0.893 Iraq-Baghdad 11879 1 0.049 0.127 0.025 0.012 0.787 raq-West 11861 3 0.088 0.068 0.151 0.018 0.674 Iraq-Baghdad 11880 4 0.015 0.014 0.176 0.017 0.779 raq-West 11863 5 0.007 0.011 0.041 0.057 0.884 Iraq-Baghdad 11881 2 0.014 0.009 0.296 0.076 0.605 raq-West 11864 1 0.011 0.033 0.112 0.027 0.818 Iraq-Baghdad 11882 3 0.013 0.006 0.219 0.008 0.755 raq-West 11888 2 0.093 0.061 0.015 0.006 0.824 Iraq-Baghdad 11883 2 0.011 0.023 0.179 0.154 0.634 raq-West 11889 4 0.006 0.024 0.06 0.119 0.791 Iraq-Baghdad 11884 13 0.026 0.016 0.034 0.015 0.909 raq-West 11890 16 0.062 0.047 0.214 0.012 0.664 Iraq-Baghdad 11885 0 0.013 0.034 0.228 0.003 0.721 raq-West 11891 15 0.007 0.025 0.333 0.014 0.621 Iraq-Baghdad 11886 2 0.057 0.088 0.232 0.008 0.615 raq-Baghdad 11847 1 0.007 0.007 0.161 0.009 0.816 Iraq-Baghdad 11887 15 0.01 0.245 0.088 0.01 0.647 raq-Baghdad 11848 1 0.036 0.157 0.024 0.013 0.77 Iran 9419 18 0.012 0.027 0.049 0.068 0.844 raq-Baghdad 11849 1 0.006 0.012 0.303 0.022 0.657 Iran 9420 14 0.122 0.044 0.038 0.013 0.784 raq-Baghdad 11850 1 0.028 0.011 0.025 0.076 0.859 Iran 9421 17 0.01 0.01 0.059 0.01 0.911 raq-Baghdad 11852 14 0.013 0.068 0.022 0.008 0.89 Iran 9422 15 0.05 0.019 0.135 0.008 0.788 raq-Baghdad 11853 8 0.039 0.047 0.099 0.01 0.805 Iran 9424 21 0.03 0.012 0.006 0.004 0.949 raq-Baghdad 11855 19 0.014 0.04 0.059 0.01 0.877 Iran 9425 4 0.018 0.009 0.01 0.003 0.959 raq-Baghdad 11856 1 0.004 0.032 0.149 0.042 0.773 Iran 9426 5 0.034 0.017 0.011 0.019 0.919 raq-Baghdad 11857 2 0.008 0.01 0.203 0.153 0.626 Iran 9427 3 0.009 0.013 0.01 0.007 0.962 raq-Baghdad 11858 1 0.021 0.016 0.113 0.013 0.837 Iran 9428 2 0.029 0.087 0.031 0.013 0.841 raq-Baghdad 11859 3 0.008 0.012 0.091 0.044 0.845 Iran 9429 3 0.116 0.103 0.023 0.011 0.746 raq-Baghdad 11862 1 0.025 0.01 0.272 0.066 0.627 Iran 9430 9 0.02 0.081 0.138 0.035 0.726 raq-Baghdad 11865 3 0.154 0.022 0.213 0.01 0.601 Iran 9431 1 0.025 0.236 0.02 0.006 0.713 raq-Baghdad 11868 8 0.02 0.022 0.036 0.007 0.916 Iran 9432 3 0.021 0.023 0.007 0.004 0.946 raq-Baghdad 11869 7 0.011 0.012 0.124 0.151 0.701 Iran 9433 2 0.052 0.016 0.027 0.032 0.872 raq-Baghdad 11870 1 0.019 0.018 0.29 0.139 0.532 Iran 9434 2 0.033 0.029 0.018 0.043 0.877 raq-Baghdad 11871 2 0.01 0.073 0.388 0.017 0.512 Iran 9435 2 0.017 0.017 0.005 0.005 0.956 raq-Baghdad 11872 3 0.003 0.017 0.159 0.02 0.8 Iran 9436 15 0.005 0.011 0.009 0.005 0.969 raq-Baghdad 11873 3 0.016 0.017 0.464 0.005 0.499 Iran 9437 1 0.006 0.018 0.008 0.005 0.962 raq-Baghdad 11874 1 0.035 0.007 0.191 0.016 0.751 Iran 9438 1 0.014 0.005 0.004 0.003 0.974 raq-Baghdad 11875 4 0.04 0.185 0.029 0.008 0.738 Iran 9439 1 0.018 0.019 0.008 0.008 0.946 raq-Baghdad 11876 5 0.011 0.133 0.104 0.005 0.747 Iran 9440 1 0.002 0.007 0.006 0.002 0.982 raq-Baghdad 11877 3 0.033 0.015 0.256 0.006 0.69 Iran 9441 2 0.003 0.005 0.003 0.003 0.987
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Iran 9442 2 0.012 0.019 0.01 0.005 0.954 Iran 9475 2 0.004 0.01 0.008 0.006 0.973
Iran 9443 2 0.007 0.008 0.005 0.005 0.975 Iran 9476 3 0.005 0.004 0.005 0.004 0.981
Iran 9444 1 0.005 0.003 0.003 0.002 0.985 Iran 9477 2 0.017 0.006 0.007 0.008 0.962
Iran 9445 2 0.004 0.003 0.003 0.002 0.988 Iran 9478 1 0.023 0.065 0.011 0.007 0.894
Iran 9446 3 0.01 0.008 0.004 0.004 0.975 Iran 9479 2 0.004 0.003 0.003 0.003 0.987
Iran 9447 19 0.004 0.015 0.004 0.005 0.972 Iran 9480 3 0.009 0.027 0.006 0.004 0.954
Iran 9448 3 0.004 0.006 0.004 0.003 0.983 Iran 9481 3 0.039 0.012 0.007 0.014 0.928
Iran 9449 1 0.005 0.003 0.003 0.002 0.987 Iran 9482 2 0.014 0.037 0.007 0.008 0.934
Iran 9450 2 0.007 0.004 0.006 0.003 0.979 Iran 9483 4 0.206 0.017 0.018 0.01 0.75
Iran 9451 3 0.018 0.009 0.004 0.003 0.967 Iran 9484 2 0.004 0.017 0.192 0.04 0.747
Iran 9452 1 0.006 0.006 0.004 0.006 0.979 Iran 9485 2 0.046 0.01 0.008 0.004 0.932
Iran 9453 3 0.002 0.003 0.004 0.002 0.989 Iran 9486 3 0.004 0.009 0.006 0.008 0.973
Iran 9454 1 0.003 0.003 0.003 0.002 0.99 Iran 9487 2 0.007 0.022 0.007 0.004 0.96
Iran 9455 3 0.006 0.016 0.013 0.007 0.957 Iran 9488 3 0.007 0.008 0.017 0.009 0.959
Iran 9456 3 0.007 0.009 0.004 0.003 0.977 Iran 9489 3 0.007 0.032 0.015 0.009 0.936
Iran 9457 3 0.003 0.004 0.005 0.004 0.985 Iran 9490 3 0.006 0.008 0.003 0.005 0.977
Iran 9458 1 0.005 0.005 0.003 0.002 0.985 Iran 9491 2 0.004 0.004 0.003 0.002 0.987
Iran 9459 2 0.004 0.008 0.003 0.003 0.983 Iran 9492 3 0.004 0.011 0.006 0.006 0.973
Iran 9460 2 0.013 0.012 0.012 0.009 0.955 Iran 9493 1 0.014 0.005 0.004 0.005 0.971
Iran 9461 3 0.004 0.009 0.005 0.007 0.975 Iran 9494 2 0.003 0.004 0.005 0.003 0.985
Iran 9462 2 0.006 0.017 0.004 0.009 0.965 Iran 9495 1 0.004 0.007 0.004 0.004 0.981
Iran 9463 3 0.006 0.006 0.004 0.003 0.981 Iran 9497 3 0.006 0.012 0.004 0.003 0.975
Iran 9464 2 0.009 0.005 0.003 0.003 0.98 Iran 9498 2 0.006 0.004 0.004 0.003 0.984
Iran 9465 2 0.003 0.007 0.008 0.004 0.978 Iran 9499 3 0.023 0.006 0.006 0.004 0.962
Iran 9466 3 0.005 0.031 0.009 0.004 0.95 Iran 9500 2 0.004 0.009 0.003 0.003 0.982
Iran 9468 3 0.023 0.007 0.007 0.007 0.956 Iran 9501 1 0.005 0.04 0.014 0.03 0.91
Iran 9469 2 0.031 0.007 0.009 0.015 0.937 Iran 9502 4 0.017 0.005 0.011 0.005 0.963
Iran 9470 3 0.025 0.009 0.009 0.007 0.95 Iran 9503 3 0.007 0.02 0.006 0.011 0.956
Iran 9471 2 0.006 0.008 0.011 0.015 0.96 Iran 9504 2 0.002 0.003 0.003 0.002 0.99
Iran 9472 2 0.021 0.012 0.008 0.003 0.956 Iran 9505 2 0.003 0.003 0.003 0.003 0.989
Iran 9473 1 0.005 0.008 0.003 0.004 0.98 Iran 9506 6 0.012 0.077 0.006 0.033 0.872
Iran 9474 1 0.006 0.009 0.013 0.013 0.959 Iran 9507 6 0.013 0.051 0.023 0.048 0.865
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Iran 9508 3 0.011 0.011 0.004 0.003 0.971 Dubai 10112 2 0.036 0.808 0.081 0.011 0.064
Iran 9509 5 0.019 0.006 0.005 0.005 0.965 Dubai 10120 3 0.006 0.871 0.008 0.006 0.109
Iran 9510 4 0.015 0.006 0.003 0.003 0.972 Kenya-Nairobi 9833 4 0.019 0.044 0.01 0.694 0.234
Iran 9511 3 0.006 0.006 0.007 0.007 0.974 Kenya-Nairobi 9834 0 0.083 0.332 0.029 0.54 0.017
Iran 9512 6 0.009 0.01 0.008 0.008 0.966 Kenya-Nairobi 9835 0 0.039 0.353 0.533 0.068 0.007
Iran 9513 5 0.006 0.021 0.008 0.007 0.958 Kenya-Nairobi 9836 2 0.044 0.322 0.009 0.619 0.005
Iran 9514 4 0.013 0.016 0.105 0.019 0.848 Kenya-Nairobi 9837 2 0.163 0.035 0.023 0.758 0.021
Iran 9515 4 0.006 0.016 0.004 0.007 0.967 Kenya-Nairobi 9838 4 0.012 0.135 0.218 0.545 0.091
Iran 9516 7 0.008 0.021 0.007 0.006 0.958 Kenya-Nairobi 9839 1 0.032 0.439 0.013 0.498 0.017
Iran 9517 3 0.029 0.009 0.006 0.009 0.947 Kenya-Nairobi 9840 3 0.013 0.306 0.082 0.579 0.02
Iran 9518 3 0.012 0.036 0.01 0.012 0.931 Kenya-Nairobi 9841 3 0.02 0.219 0.01 0.739 0.012
Iran 9519 4 0.007 0.013 0.009 0.017 0.954 Kenya-Nairobi 9842 2 0.038 0.286 0.045 0.603 0.028
Iran 9520 4 0.003 0.021 0.006 0.006 0.963 Kenya-Nairobi 9843 4 0.034 0.327 0.017 0.612 0.01
Iran 9521 8 0.008 0.114 0.006 0.008 0.864 Kenya-Nairobi 9844 3 0.096 0.155 0.017 0.722 0.01
Iran 9522 9 0.024 0.019 0.04 0.006 0.912 Kenya-Nairobi 9845 1 0.038 0.17 0.113 0.668 0.011
Iran 9523 3 0.005 0.021 0.038 0.024 0.913 Kenya-Nairobi 9846 1 0.061 0.332 0.019 0.565 0.022
Iran 9524 3 0.01 0.005 0.003 0.002 0.98 Kenya-Nairobi 9847 3 0.023 0.216 0.012 0.737 0.012
Iran 9526 4 0.009 0.005 0.003 0.002 0.98 Kenya-Nairobi 9848 3 0.069 0.173 0.141 0.604 0.013
Iran 9527 3 0.016 0.058 0.011 0.006 0.909 Kenya-Nairobi 9849 2 0.029 0.653 0.016 0.297 0.004
Iran 9528 5 0.007 0.005 0.003 0.003 0.981 Kenya-Nairobi 9850 3 0.016 0.118 0.052 0.779 0.035
Iran 9529 4 0.009 0.014 0.003 0.002 0.972 Kenya-Nairobi 9851 2 0.016 0.527 0.01 0.436 0.012
Iran 9530 5 0.007 0.006 0.005 0.003 0.979 Kenya-Nairobi 9852 4 0.012 0.534 0.033 0.415 0.006
Iran 9531 4 0.018 0.102 0.024 0.01 0.846 Kenya-Nairobi 9853 4 0.039 0.315 0.01 0.601 0.035
Iran 9532 14 0.011 0.014 0.033 0.028 0.914 Kenya-Nairobi 9854 2 0.012 0.286 0.047 0.617 0.039
Dubai 10104 1 0.002 0.796 0.055 0.02 0.127 Kenya-Nairobi 9855 2 0.015 0.383 0.048 0.534 0.02
Dubai 10105 2 0.011 0.746 0.011 0.01 0.222 Kenya-Nairobi 9856 3 0.013 0.39 0.026 0.563 0.009
Dubai 10106 4 0.006 0.941 0.006 0.004 0.042 Kenya-Nairobi 9857 6 0.108 0.163 0.031 0.683 0.015
Dubai 10107 1 0.047 0.476 0.024 0.03 0.424 Kenya-Nairobi 9858 3 0.028 0.318 0.01 0.635 0.01
Dubai 10108 2 0.048 0.843 0.047 0.009 0.054 Kenya-Nairobi 9859 4 0.199 0.018 0.006 0.766 0.011
Dubai 10109 4 0.125 0.501 0.009 0.009 0.356 Kenya-Nairobi 9860 2 0.167 0.11 0.01 0.705 0.008
Dubai 10110 3 0.006 0.791 0.013 0.014 0.176 Kenya-Nairobi 9861 1 0.011 0.178 0.048 0.744 0.02
Dubai 10111 4 0.004 0.937 0.008 0.004 0.048 Kenya-Nairobi 9862 2 0.037 0.337 0.049 0.571 0.004
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kenya- Nairobi 9863 1 0.035 0.536 0.006 0.417 0.006 Kenya-Lamu 3241 4 0.013 0.917 0.036 0.026 0.008
Kenya- Nairobi 9864 2 0.01 0.393 0.021 0.53 0.045 Kenya-Lamu 3246 2 0.006 0.908 0.052 0.028 0.007
Kenya- Nairobi 9865 4 0.062 0.277 0.022 0.614 0.025 Kenya-Lamu 3247 3 0.013 0.865 0.017 0.091 0.013
Kenya- Nairobi 9866 3 0.075 0.222 0.06 0.635 0.008 India-Udaipur 11835 8 0.357 0.374 0.024 0.01 0.235
Kenya- Nairobi 9867 0 0.059 0.319 0.019 0.578 0.025 India-Udaipur 11836 3 0.031 0.581 0.013 0.012 0.363
Kenya-Nairobi 9868 5 0.021 0.219 0.132 0.606 0.021 India-Udaipur 11837 2 0.063 0.682 0.01 0.003 0.242
Kenya- Pate 2000 2 0.006 0.916 0.024 0.045 0.009 India-Agra 11823 1 0.04 0.553 0.014 0.005 0.389
Kenya- Pate 2001 3 0.004 0.97 0.003 0.003 0.02 India-Agra 11824 2 0.006 0.739 0.024 0.005 0.226
Kenya- Pate 2002 1 0.006 0.948 0.004 0.003 0.038 India-Agra 11825 2 0.099 0.353 0.009 0.007 0.532
Kenya- Pate 2003 0 0.006 0.974 0.005 0.009 0.007 India-Agra 11826 6 0.044 0.52 0.008 0.004 0.425
Kenya- Pate 2004 3 0.007 0.963 0.015 0.005 0.01 India-Agra 11827 19 0.012 0.555 0.012 0.004 0.417
Kenya- Pate 2006 3 0.021 0.92 0.01 0.015 0.034 India-Agra 11828 2 0.023 0.618 0.118 0.007 0.233
Kenya- Pate 2007 4 0.005 0.963 0.012 0.011 0.008 India-Agra 11829 4 0.018 0.633 0.012 0.008 0.329
Kenya- Pate 2009 6 0.005 0.86 0.083 0.034 0.018 India-Agra 11830 8 0.013 0.546 0.008 0.004 0.429
Kenya- Pate 2011 3 0.004 0.982 0.008 0.003 0.003 India-Agra 11831 3 0.061 0.39 0.034 0.007 0.507
Kenya-Lamu 1848 13 0.009 0.969 0.008 0.009 0.005 India-Agra 11832 2 0.016 0.466 0.007 0.003 0.508
Kenya-Lamu 2014 4 0.005 0.922 0.02 0.019 0.033 India-Agra 11833 16 0.049 0.634 0.018 0.004 0.294
Kenya-Lamu 2015 2 0.009 0.89 0.063 0.032 0.006 India-Agra 11834 3 0.051 0.484 0.008 0.005 0.452
Kenya-Lamu 2016 2 0.007 0.963 0.015 0.009 0.007 India-
Kenya-Lamu 2018 1 0.004 0.841 0.02 0.127 0.008 Hyderbad 11802 13 0.104 0.604 0.271 0.011 0.009
Kenya-Lamu 2019 2 0.005 0.923 0.04 0.027 0.005 India-
Kenya-Lamu 2021 2 0.006 0.866 0.018 0.027 0.083 Hyderbad 11803 7 0.021 0.883 0.05 0.004 0.043
Kenya-Lamu 2023 3 0.005 0.976 0.006 0.008 0.005 India-
Kenya-Lamu 2024 2 0.003 0.977 0.005 0.004 0.01 Hyderbad 11804 5 0.445 0.516 0.005 0.003 0.031
Kenya-Lamu 2025 3 0.009 0.946 0.016 0.009 0.02 India-
Kenya-Lamu 2026 4 0.005 0.938 0.046 0.006 0.006 Hyderbad 11805 10 0.042 0.901 0.023 0.01 0.023
Kenya-Lamu 2027 6 0.017 0.916 0.008 0.02 0.039 India-
Kenya-Lamu 2029 2 0.003 0.981 0.005 0.003 0.008 Hyderbad 11807 11 0.099 0.858 0.014 0.008 0.02
Kenya-Lamu 2030 1 0.003 0.962 0.007 0.02 0.008 India-
Kenya-Lamu 2031 4 0.009 0.929 0.017 0.017 0.029 Hyderbad 11808 9 0.251 0.72 0.01 0.014 0.005
Kenya-Lamu 2032 2 0.007 0.833 0.011 0.008 0.142 India-
Kenya-Lamu 2033 2 0.003 0.971 0.012 0.004 0.009 Hyderbad 11809 3 0.008 0.73 0.053 0.141 0.068
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
India- India-Andhra 10165 1 0.08 0.895 0.008 0.007 0.011
Hyderbad 11810 0 0.234 0.66 0.049 0.007 0.05 India-Andhra 10166 3 0.064 0.887 0.023 0.019 0.007
India- India-Andhra 10167 1 0.199 0.732 0.04 0.024 0.005
Hyderbad 11811 0 0.015 0.949 0.017 0.012 0.007 India-Andhra 10168 1 0.127 0.822 0.025 0.012 0.015
India- India-Andhra 10169 6 0.217 0.749 0.011 0.018 0.005
Hyderbad 11812 3 0.097 0.715 0.009 0.003 0.176 India-Andhra 10170 4 0.293 0.664 0.025 0.013 0.004
India- India-Andhra 10171 1 0.323 0.598 0.011 0.012 0.056
Hyderbad 11813 4 0.392 0.543 0.037 0.006 0.023 India-Andhra 10172 2 0.106 0.837 0.011 0.02 0.026
India- India-Andhra 10173 2 0.223 0.752 0.011 0.009 0.005
Hyderbad 11814 2 0.024 0.908 0.021 0.005 0.042 India-Andhra 10174 3 0.194 0.784 0.01 0.009 0.003
India- India-Andhra 10175 2 0.105 0.793 0.024 0.067 0.011
Hyderbad 11815 2 0.134 0.802 0.025 0.008 0.031 India-Andhra 10176 2 0.358 0.585 0.025 0.011 0.021
India- India-Andhra 10177 0 0.271 0.632 0.009 0.077 0.01
Hyderbad 11816 3 0.007 0.954 0.007 0.004 0.029 India-Andhra 10178 3 0.152 0.822 0.007 0.007 0.012
India- India-Andhra 10179 4 0.048 0.924 0.005 0.018 0.004
Hyderbad 11817 2 0.134 0.837 0.011 0.004 0.014 India-Andhra 10180 10 0.113 0.676 0.113 0.066 0.032
India- India-Andhra 10181 5 0.368 0.608 0.01 0.007 0.006
Hyderbad 11818 1 0.057 0.86 0.019 0.057 0.006 India-Kolkata 10113 2 0.056 0.91 0.014 0.007 0.013
India- India-Kolkata 10114 1 0.09 0.889 0.007 0.004 0.01
Hyderbad 11819 4 0.007 0.954 0.009 0.005 0.024 India-Kolkata 10115 1 0.086 0.806 0.088 0.012 0.008
India- India-Kolkata 10116 2 0.072 0.911 0.006 0.003 0.01
Hyderbad 11820 5 0.152 0.817 0.007 0.003 0.021 India-Kolkata 10117 2 0.283 0.621 0.076 0.007 0.014
India- India-Kolkata 10118 3 0.197 0.543 0.204 0.022 0.034
Hyderbad 11821 13 0.309 0.647 0.024 0.005 0.015 India-Kolkata 10119 3 0.035 0.73 0.093 0.096 0.046
India- Sri Lanka 8780 1 0.194 0.677 0.023 0.095 0.01
Hyderbad 11822 2 0.17 0.764 0.037 0.008 0.021 Sri Lanka 8781 1 0.18 0.657 0.037 0.117 0.009
India-Andhra 10159 2 0.313 0.638 0.025 0.012 0.012 Sri Lanka 8782 3 0.055 0.759 0.101 0.07 0.015
India-Andhra 10160 1 0.455 0.529 0.005 0.004 0.006 Sri Lanka 8783 0 0.014 0.827 0.108 0.041 0.01
India-Andhra 10161 2 0.051 0.922 0.005 0.008 0.014 Sri Lanka 8784 1 0.283 0.439 0.016 0.25 0.012
India-Andhra 10162 5 0.188 0.782 0.008 0.009 0.014 Sri Lanka 8785 10 0.033 0.768 0.015 0.151 0.033
India-Andhra 10163 0 0.122 0.86 0.005 0.005 0.009 Sri Lanka 8786 0 0.061 0.675 0.124 0.097 0.043
India-Andhra 10164 2 0.314 0.611 0.01 0.013 0.053 Sri Lanka 8787 0 0.006 0.747 0.011 0.229 0.007
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Sri Lanka 8788 4 0.061 0.697 0.077 0.076 0.088 Thailand 11720 4 0.982 0.008 0.004 0.002 0.004
Sri Lanka 8789 2 0.065 0.448 0.107 0.363 0.017 Vietnam 8844 4 0.845 0.137 0.004 0.007 0.007
Sri Lanka 8790 1 0.054 0.64 0.021 0.279 0.007 Vietnam 8845 3 0.694 0.269 0.014 0.007 0.016
Sri Lanka 8791 1 0.032 0.892 0.046 0.017 0.013 Vietnam 8846 3 0.545 0.408 0.031 0.012 0.004
Sri Lanka 8792 0 0.016 0.772 0.085 0.104 0.023 Vietnam 8847 10 0.933 0.021 0.009 0.029 0.008
Sri Lanka 8793 2 0.011 0.653 0.027 0.282 0.027 Vietnam 8848 6 0.778 0.187 0.017 0.013 0.005
Sri Lanka 8794 2 0.024 0.62 0.079 0.236 0.041 Vietnam 8849 2 0.87 0.054 0.057 0.015 0.005
Sri Lanka 8795 1 0.076 0.651 0.059 0.208 0.007 Vietnam 8850 1 0.735 0.022 0.014 0.222 0.007
Sri Lanka 8796 4 0.272 0.621 0.071 0.03 0.006 Vietnam 8851 2 0.713 0.088 0.067 0.031 0.1
Sri Lanka 8797 1 0.087 0.487 0.008 0.355 0.063 Vietnam 8852 13 0.721 0.067 0.157 0.043 0.011
Sri Lanka 8798 1 0.134 0.528 0.259 0.059 0.02 Vietnam 8853 3 0.605 0.134 0.201 0.055 0.006
Sri Lanka 8799 2 0.007 0.69 0.005 0.285 0.013 Vietnam 8854 5 0.739 0.048 0.039 0.05 0.125
Sri Lanka 8800 2 0.227 0.375 0.02 0.365 0.013 Vietnam 8855 2 0.738 0.021 0.046 0.19 0.005
Sri Lanka 8801 5 0.006 0.755 0.013 0.197 0.029 Vietnam 8856 2 0.634 0.164 0.185 0.01 0.008
Sri Lanka 8802 2 0.019 0.591 0.006 0.371 0.013 Vietnam 8857 3 0.35 0.608 0.018 0.015 0.009
Sri Lanka 8803 6 0.131 0.771 0.03 0.061 0.006 Vietnam 8858 2 0.673 0.084 0.175 0.062 0.006
Thailand 11688 6 0.965 0.018 0.004 0.01 0.003 Vietnam 8859 7 0.647 0.319 0.015 0.01 0.009
Thailand 11689 13 0.94 0.024 0.004 0.004 0.028 Vietnam 8860 2 0.784 0.051 0.114 0.04 0.01
Thailand 11691 27 0.959 0.019 0.008 0.008 0.005 Vietnam 8861 2 0.608 0.212 0.118 0.022 0.041
Thailand 11698 18 0.978 0.008 0.007 0.003 0.004 Vietnam 8862 2 0.414 0.55 0.016 0.012 0.009
Thailand 11702 10 0.977 0.012 0.004 0.004 0.003 Vietnam 8863 3 0.624 0.071 0.104 0.178 0.022
Thailand 11703 12 0.983 0.007 0.003 0.003 0.004 Taiwan 8681 4 0.326 0.005 0.005 0.658 0.005
Thailand 11705 21 0.853 0.107 0.027 0.005 0.009 Taiwan 8682 0 0.876 0.052 0.014 0.019 0.04
Thailand 11707 4 0.972 0.017 0.005 0.003 0.004 Taiwan 8683 3 0.7 0.03 0.071 0.152 0.047
Thailand 11708 18 0.897 0.055 0.028 0.012 0.009 Taiwan 8684 3 0.36 0.005 0.008 0.619 0.008
Thailand 11709 12 0.974 0.011 0.007 0.004 0.005 Taiwan 8685 2 0.898 0.033 0.011 0.054 0.004
Thailand 11710 9 0.974 0.01 0.008 0.004 0.004 Taiwan 8686 6 0.672 0.016 0.017 0.283 0.012
Thailand 11711 6 0.975 0.012 0.003 0.006 0.005 Taiwan 8687 5 0.801 0.035 0.1 0.026 0.038
Thailand 11714 6 0.883 0.09 0.01 0.006 0.012 Taiwan 8688 26 0.821 0.111 0.019 0.033 0.016
Thailand 11715 17 0.814 0.061 0.006 0.008 0.111 Taiwan 8689 5 0.715 0.023 0.035 0.064 0.163
Thailand 11717 15 0.877 0.1 0.005 0.003 0.015 Taiwan 8690 2 0.892 0.017 0.008 0.011 0.073
Thailand 11718 2 0.965 0.018 0.004 0.007 0.005 Taiwan 8691 16 0.776 0.137 0.023 0.053 0.011
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Taiwan 8692 3 0.922 0.018 0.012 0.034 0.013 Japan-Oita 11982 6 0.923 0.018 0.011 0.04 0.008
Taiwan 8693 2 0.807 0.033 0.015 0.134 0.011 Japan-Oita 11985 11 0.952 0.012 0.023 0.007 0.005
Taiwan 8694 1 0.541 0.02 0.005 0.428 0.007 Japan-Oita 11986 7 0.668 0.008 0.037 0.28 0.007
Taiwan 8695 1 0.837 0.01 0.063 0.086 0.005 Japan-
Taiwan 8696 11 0.01 0.005 0.005 0.976 0.003 Kanazawa 11929 7 0.003 0.004 0.004 0.984 0.004
Taiwan 8697 1 0.021 0.014 0.017 0.932 0.016 Japan-
Taiwan 8698 4 0.004 0.004 0.005 0.985 0.003 Kanazawa 11931 18 0.926 0.025 0.005 0.034 0.01
Taiwan 8699 6 0.493 0.244 0.056 0.08 0.128 Japan-
Taiwan 8700 2 0.659 0.031 0.054 0.241 0.015 Kanazawa 11932 6 0.772 0.009 0.006 0.207 0.007
Taiwan 8701 2 0.777 0.016 0.007 0.194 0.006 Japan-
Taiwan 8702 2 0.627 0.036 0.058 0.261 0.017 Kanazawa 11933 14 0.844 0.078 0.018 0.055 0.004
Taiwan 8703 2 0.012 0.012 0.014 0.958 0.005 Japan-
Taiwan 8704 1 0.843 0.032 0.104 0.016 0.005 Kanazawa 11934 4 0.88 0.004 0.006 0.108 0.002
Taiwan 8705 2 0.827 0.113 0.023 0.013 0.023 Japan-
Taiwan 8706 2 0.755 0.053 0.085 0.074 0.033 Kanazawa 11936 8 0.952 0.011 0.01 0.023 0.004
Taiwan 8707 5 0.844 0.015 0.014 0.022 0.105 Japan-
Taiwan 8708 3 0.01 0.007 0.005 0.974 0.004 Kanazawa 11937 23 0.957 0.008 0.008 0.023 0.005
Taiwan 8709 4 0.911 0.024 0.023 0.025 0.018 Japan-
Japan-Oita 11967 4 0.936 0.018 0.024 0.014 0.008 Kanazawa 11939 18 0.965 0.014 0.005 0.01 0.005
Japan-Oita 11968 5 0.741 0.045 0.022 0.188 0.005 Japan-
Japan-Oita 11969 5 0.849 0.009 0.05 0.085 0.007 Kanazawa 11940 12 0.97 0.007 0.007 0.006 0.011
Japan-Oita 11970 15 0.848 0.02 0.104 0.013 0.015 Japan-
Japan-Oita 11971 8 0.893 0.047 0.018 0.025 0.017 Kanazawa 11941 7 0.954 0.006 0.014 0.009 0.017
Japan-Oita 11972 3 0.945 0.014 0.02 0.015 0.006 Japan-
Japan-Oita 11973 3 0.716 0.009 0.008 0.26 0.008 Kanazawa 11942 9 0.956 0.031 0.005 0.004 0.004
Japan-Oita 11974 20 0.914 0.054 0.016 0.008 0.008 Japan-
Japan-Oita 11975 19 0.759 0.066 0.03 0.143 0.003 Kanazawa 11943 19 0.858 0.064 0.02 0.014 0.045
Japan-Oita 11976 16 0.843 0.007 0.01 0.133 0.006 Japan-
Japan-Oita 11977 5 0.924 0.013 0.011 0.045 0.007 Kanazawa 11944 13 0.035 0.104 0.072 0.762 0.026
Japan-Oita 11979 11 0.946 0.018 0.012 0.014 0.009 Japan-
Japan-Oita 11980 18 0.949 0.022 0.011 0.009 0.009 Kanazawa 11945 16 0.919 0.015 0.008 0.051 0.007
Japan-Oita 11981 16 0.985 0.006 0.003 0.002 0.004 Japan- 11946 15 0.98 0.007 0.006 0.005 0.003
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
Kanazawa Sapporo
Japan-Ohmiya 11947 4 0.841 0.008 0.074 0.073 0.005 Japan-
Japan-Ohmiya 11948 16 0.834 0.023 0.052 0.024 0.067 Sapporo 11918 12 0.65 0.083 0.016 0.238 0.012
Japan-Ohmiya 11951 18 0.778 0.057 0.031 0.081 0.053 Japan-
Japan-Ohmiya 11953 3 0.982 0.004 0.006 0.005 0.004 Sapporo 11921 5 0.923 0.047 0.01 0.005 0.015
Japan-Ohmiya 11954 3 0.763 0.009 0.01 0.208 0.01 Japan-
Japan-Ohmiya 11955 5 0.678 0.013 0.007 0.296 0.005 Sapporo 11922 5 0.795 0.165 0.008 0.024 0.008
Japan-Ohmiya 11956 3 0.964 0.017 0.008 0.007 0.005 Japan-
Japan-Ohmiya 11957 3 0.762 0.025 0.071 0.129 0.013 Sapporo 11923 7 0.938 0.028 0.008 0.021 0.005
Japan-Ohmiya 11959 6 0.862 0.014 0.07 0.047 0.006 Japan-
Japan-Ohmiya 11960 3 0.982 0.005 0.003 0.005 0.005 Sapporo 11924 5 0.401 0.011 0.009 0.574 0.005
Japan-Ohmiya 11961 3 0.962 0.008 0.015 0.01 0.005 Japan-
Japan-Ohmiya 11962 5 0.77 0.039 0.019 0.165 0.007 Sapporo 11925 9 0.972 0.016 0.005 0.003 0.004
Japan-Ohmiya 11963 3 0.85 0.031 0.01 0.102 0.007 Japan-
Japan-Ohmiya 11964 4 0.747 0.05 0.012 0.171 0.02 Sapporo 11926 10 0.579 0.009 0.152 0.25 0.011
Japan-Ohmiya 11965 4 0.718 0.246 0.022 0.008 0.005 China-Henan 8869 2 0.882 0.009 0.051 0.011 0.047
Japan-Ohmiya 11966 4 0.847 0.022 0.026 0.089 0.017 China-Henan 8870 1 0.981 0.005 0.004 0.003 0.008
Japan- China-Henan 8871 1 0.788 0.014 0.014 0.005 0.179
Sapporo 11907 6 0.929 0.011 0.016 0.028 0.015 China-Henan 8872 1 0.961 0.008 0.009 0.006 0.016
Japan- China-Henan 8873 2 0.953 0.005 0.011 0.004 0.027
Sapporo 11909 9 0.007 0.005 0.005 0.979 0.004 China-Henan 8874 8 0.845 0.028 0.005 0.003 0.12
Japan- China-Henan 8875 2 0.985 0.004 0.004 0.003 0.003
Sapporo 11911 15 0.582 0.008 0.008 0.392 0.009 China-Henan 8876 1 0.985 0.005 0.004 0.003 0.003
Japan- China-Henan 8877 2 0.817 0.061 0.025 0.023 0.074
Sapporo 11913 14 0.681 0.012 0.011 0.292 0.004 China-Henan 8878 3 0.952 0.007 0.03 0.004 0.007
Japan- China-Henan 8879 2 0.971 0.009 0.005 0.003 0.012
Sapporo 11914 6 0.761 0.027 0.017 0.189 0.006 China-Henan 8880 2 0.877 0.015 0.009 0.036 0.063
Japan- China-Henan 8881 2 0.836 0.013 0.053 0.003 0.095
Sapporo 11915 8 0.955 0.013 0.01 0.013 0.01 China-Henan 8882 2 0.906 0.034 0.023 0.014 0.022
Japan- China-Henan 8883 0 0.969 0.005 0.005 0.004 0.016
Sapporo 11916 6 0.011 0.013 0.046 0.926 0.003 China-Henan 8884 0 0.89 0.031 0.006 0.002 0.071
Japan- 11917 4 0.018 0.033 0.02 0.911 0.018 China-Henan 8885 1 0.92 0.019 0.021 0.012 0.028
Table 22 - Population clustering of each random bred Table 22 - Population clustering of each random bred individual in the database by SNPs and STRs at K = 5 individual in the database by SNPs and STRs at K = 5
Sampling ID Missing Population Sampling ID Missing Population
Location No. Data 1 2 3 4 5 Location No. Data 1 2 3 4 5
China-Henan 8886 1 0.97 0.004 0.009 0.004 0.013 South Korea 7692 1 0.851 0.033 0.064 0.023 0.028
China-Henan 8887 1 0.844 0.009 0.02 0.008 0.118 South Korea 7693 0 0.805 0.077 0.069 0.028 0.022
China-Henan 8888 1 0.948 0.01 0.008 0.01 0.024 South Korea 7694 2 0.981 0.008 0.005 0.002 0.004
South Korea 2769 4 0.972 0.003 0.008 0.004 0.013 South Korea 7695 9 0.695 0.009 0.229 0.051 0.015
South Korea 2772 19 0.97 0.014 0.005 0.004 0.007 South Korea 7696 2 0.974 0.004 0.008 0.006 0.008
South Korea 2775 9 0.97 0.007 0.007 0.006 0.011 South Korea 7697 3 0.899 0.009 0.016 0.039 0.037
South Korea 2776 23 0.922 0.042 0.024 0.007 0.006 South Korea 7698 6 0.82 0.013 0.143 0.01 0.014
South Korea 2779 1 0.967 0.01 0.005 0.006 0.012 South Korea 7699 2 0.952 0.004 0.025 0.01 0.009
South Korea 2784 2 0.959 0.011 0.009 0.004 0.017 South Korea 7700 6 0.957 0.01 0.01 0.006 0.017
South Korea 2785 1 0.892 0.007 0.009 0.007 0.085
South Korea 2786 2 0.986 0.003 0.005 0.004 0.002
South Korea 7671 1 0.897 0.004 0.038 0.053 0.007
South Korea 7672 0 0.954 0.027 0.009 0.004 0.006
South Korea 7673 1 0.862 0.004 0.066 0.009 0.059
South Korea 7674 1 0.727 0.028 0.086 0.114 0.045
South Korea 7675 3 0.981 0.004 0.006 0.005 0.004
South Korea 7676 3 0.907 0.009 0.019 0.053 0.012
South Korea 7677 14 0.162 0.011 0.034 0.613 0.18
South Korea 7678 1 0.938 0.006 0.01 0.036 0.01
South Korea 7679 2 0.969 0.005 0.011 0.005 0.011
South Korea 7680 8 0.799 0.008 0.061 0.118 0.013
South Korea 7681 4 0.909 0.004 0.067 0.009 0.012
South Korea 7682 1 0.977 0.006 0.009 0.004 0.004
South Korea 7683 2 0.975 0.009 0.004 0.003 0.009
South Korea 7684 2 0.436 0.019 0.083 0.436 0.026
South Korea 7685 8 0.901 0.039 0.029 0.017 0.013
South Korea 7686 3 0.903 0.007 0.023 0.056 0.011
South Korea 7687 5 0.846 0.017 0.02 0.113 0.004
South Korea 7688 11 0.535 0.005 0.006 0.45 0.003
South Korea 7689 2 0.957 0.006 0.007 0.008 0.022
South Korea 7690 2 0.902 0.027 0.041 0.023 0.007
South Korea 7691 3 0.973 0.009 0.007 0.005 0.005
Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
USA-NY 2547 1 0.8149 0.02 0.0204 0.0175 0.0471 0.0288 0.0087 0.0426
USA-NY 2559 0 0.5437 0.0368 0.1514 0.0059 0.0184 0.0713 0.05 0.1224
USA-NY 2568 0 0.965 0.0055 0.0054 0.0042 0.0058 0.007 0.0041 0.003
USA-NY 2569 1 0.9214 0.0148 0.0084 0.0146 0.0116 0.0116 0.0043 0.0133
USA-NY 2572 0 0.9093 0.0225 0.0219 0.0134 0.0058 0.0128 0.0043 0.01
USA-NY 2578 20 0.7478 0.076 0.0405 0.0482 0.0264 0.0316 0.0068 0.0227
USA-NY 2590 0 0.9116 0.0158 0.0259 0.0058 0.0066 0.0107 0.0132 0.0104
USA-NY 2591 1 0.9247 0.0181 0.0102 0.017 0.0111 0.009 0.0048 0.0051
USA-NY 2597 1 0.8567 0.0364 0.0148 0.0483 0.013 0.0119 0.008 0.0109
USA-MS 9971 2 0.899 0.0149 0.0137 0.0077 0.0168 0.0113 0.0212 0.0154
USA-MS 9972 2 0.7381 0.0906 0.039 0.0276 0.044 0.0422 0.01 0.0085
USA-MS 9974 2 0.6857 0.0156 0.0155 0.0066 0.0062 0.009 0.2562 0.0052
USA-MS 9977 4 0.9489 0.0096 0.0125 0.0053 0.0063 0.0054 0.0031 0.0089
USA-MS 9980 1 0.8555 0.0296 0.0143 0.0142 0.0263 0.0319 0.0177 0.0105
USA-MS 9983 1 0.9283 0.0123 0.0146 0.0164 0.01 0.0067 0.0031 0.0086
USA-MS 9985 2 0.683 0.0179 0.0106 0.0162 0.024 0.0111 0.2318 0.0054
USA-MS 9987 2 0.5845 0.1533 0.104 0.0077 0.0244 0.0302 0.0569 0.039
USA-MS 9989 2 0.9404 0.008 0.0105 0.0061 0.0053 0.0112 0.0113 0.0072
USA-MS 9992 2 0.8732 0.0381 0.0277 0.0305 0.0064 0.0104 0.0052 0.0085
USA-HI 5366 1 0.7618 0.0147 0.0289 0.0152 0.0118 0.0569 0.013 0.0977
USA-HI 5367 0 0.7171 0.0163 0.0098 0.0367 0.0951 0.0654 0.0198 0.0398
USA-HI 5371 0 0.8947 0.0277 0.0266 0.0112 0.0058 0.0148 0.0128 0.0064
USA-HI 5372 0 0.4323 0.3105 0.0857 0.0461 0.0248 0.0755 0.0139 0.0111
USA-HI 5379 0 0.8471 0.0419 0.032 0.0197 0.0097 0.0275 0.0062 0.0159
USA-HI 5380 1 0.952 0.0093 0.018 0.0031 0.0032 0.0054 0.0024 0.0066
USA-HI 5383 1 0.3502 0.054 0.0307 0.2709 0.1737 0.0285 0.0282 0.0639
USA-HI 5384 2 0.87 0.0266 0.0253 0.0211 0.0215 0.016 0.0051 0.0144
USA-HI 5401 1 0.9419 0.0095 0.0105 0.0071 0.0087 0.0091 0.0071 0.0061
USA-HI 5402 0 0.8481 0.0151 0.0136 0.008 0.0124 0.0436 0.0356 0.0236
Brazil 7961 0 0.8658 0.0254 0.0433 0.0113 0.0071 0.0212 0.0099 0.016
Brazil 7962 2 0.7395 0.0339 0.0842 0.0109 0.0262 0.0436 0.0336 0.028
Brazil 7963 15 0.5211 0.0423 0.1078 0.0069 0.0148 0.0649 0.213 0.0291
Brazil 7964 1 0.874 0.0134 0.0684 0.0095 0.0065 0.0122 0.0041 0.0119
Brazil 7965 18 0.9426 0.0072 0.0058 0.0064 0.0115 0.0075 0.0079 0.0111
Brazil 7966 1 0.8629 0.0244 0.0471 0.0104 0.0092 0.0298 0.0105 0.0057
Brazil 7968 22 0.7997 0.0217 0.0308 0.0207 0.0208 0.0175 0.0144 0.0744
Brazil 7969 0 0.9541 0.0086 0.0081 0.0058 0.0079 0.0069 0.0041 0.0045
Brazil 7970 0 0.9429 0.0073 0.0083 0.0071 0.0103 0.0077 0.0057 0.0107
Brazil 7971 0 0.9351 0.0138 0.0123 0.0134 0.0059 0.0056 0.006 0.0079
Brazil 7972 0 0.8774 0.037 0.0451 0.0063 0.0071 0.0157 0.0049 0.0065
Brazil 7973 0 0.921 0.0144 0.0116 0.0092 0.0076 0.0119 0.0076 0.0167
Brazil 7974 3 0.858 0.0185 0.0765 0.0068 0.0058 0.0124 0.0107 0.0113
Brazil 7975 3 0.907 0.012 0.0212 0.0134 0.0058 0.0132 0.0061 0.0213
Brazil 7976 0 0.9157 0.0133 0.0197 0.0105 0.0056 0.014 0.0076 0.0136
Brazil 7977 1 0.8937 0.0299 0.0357 0.0067 0.0053 0.0082 0.0027 0.0178
Brazil 7978 1 0.8036 0.0277 0.0283 0.0107 0.0443 0.019 0.0094 0.0569
Brazil 7979 1 0.8596 0.0299 0.0212 0.0118 0.012 0.0164 0.0305 0.0186
Brazil 7980 2 0.6096 0.0259 0.1856 0.0116 0.0943 0.0485 0.0048 0.0198
Brazil 7981 2 0.7936 0.0137 0.0128 0.0045 0.011 0.0078 0.0051 0.1515
Brazil 7982 15 0.6989 0.0203 0.0196 0.0111 0.0546 0.0793 0.0716 0.0446
Brazil 7983 1 0.6454 0.0622 0.1221 0.0347 0.0236 0.0401 0.0362 0.0356
Brazil 7984 6 0.6041 0.0144 0.0595 0.0065 0.0114 0.0157 0.2475 0.0409
Brazil 7985 2 0.7088 0.0774 0.0858 0.005 0.0175 0.0212 0.0299 0.0545
Brazil 7986 2 0.7468 0.0334 0.0551 0.0052 0.0135 0.0204 0.1129 0.0127
Brazil 7987 1 0.8607 0.0225 0.07 0.005 0.0063 0.0125 0.0127 0.0103
Brazil 7988 0 0.7416 0.0334 0.0174 0.0057 0.0215 0.0439 0.0439 0.0927 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Brazil 7989 0 0.5809 0.0098 0.0116 0.0082 0.0067 0.0126 0.3619 0.0083
Brazil 7990 0 0.7188 0.0135 0.013 0.0067 0.0065 0.012 0.22 0.0096
Finland 8077 8 0.8471 0.06 0.0289 0.017 0.0118 0.0194 0.0046 0.0111
Finland 8084 6 0.8304 0.0319 0.0287 0.0471 0.0208 0.0151 0.0035 0.0225
Finland 8086 4 0.8111 0.0661 0.0384 0.0153 0.0093 0.0213 0.019 0.0195
Finland 8089 4 0.5705 0.1316 0.0331 0.0403 0.0242 0.166 0.0085 0.0259
Finland 8093 16 0.8786 0.0208 0.0151 0.0226 0.0116 0.0188 0.0055 0.027
Finland 8094 3 0.8916 0.0249 0.0131 0.0211 0.0106 0.026 0.0041 0.0086
Finland 8096 3 0.9442 0.0119 0.0073 0.0187 0.0069 0.0045 0.0021 0.0044
Finland 8107 22 0.9514 0.0083 0.0062 0.0071 0.0119 0.0084 0.0021 0.0046
Finland 8110 5 0.9633 0.0077 0.007 0.0043 0.0047 0.0068 0.0031 0.0031
Finland 8116 8 0.7999 0.012 0.0255 0.0115 0.0848 0.0334 0.0146 0.0183
Finland 8120 19 0.9402 0.0122 0.0102 0.004 0.0083 0.0069 0.0071 0.0111
Germany 8711 2 0.891 0.0204 0.0373 0.0088 0.009 0.008 0.0044 0.0211
Germany 8712 3 0.9323 0.0166 0.0095 0.0157 0.0076 0.0089 0.0038 0.0056
Germany 8713 2 0.6576 0.0447 0.2334 0.0079 0.018 0.0198 0.0046 0.014
Germany 8714 2 0.6758 0.1335 0.0649 0.0423 0.0232 0.0372 0.0092 0.0138
Germany 8715 4 0.9043 0.0384 0.0117 0.0192 0.011 0.006 0.0031 0.0063
Germany 8716 4 0.9015 0.0213 0.0147 0.0122 0.0088 0.0135 0.0085 0.0195
Germany 8717 12 0.9087 0.0177 0.0199 0.0174 0.0061 0.0137 0.0061 0.0104
Germany 8720 2 0.2269 0.0804 0.04 0.0094 0.0096 0.0335 0.5953 0.0049
Germany 8721 10 0.9045 0.0397 0.023 0.0062 0.0066 0.0082 0.0059 0.0059
Germany 8727 0 0.9441 0.0077 0.0097 0.0057 0.008 0.0092 0.0043 0.0113
Germany 8728 10 0.8226 0.0286 0.026 0.0247 0.0617 0.0168 0.009 0.0107
Germany 8729 1 0.953 0.0086 0.0064 0.0076 0.007 0.0064 0.0045 0.0065
Germany 8730 22 0.7621 0.0083 0.0079 0.0101 0.0613 0.0139 0.0096 0.1268
Germany 8731 12 0.9541 0.007 0.007 0.0054 0.0124 0.0058 0.0021 0.0062
Germany 8732 3 0.8954 0.0342 0.0309 0.0086 0.0158 0.0076 0.0029 0.0046
Germany 8733 14 0.8288 0.033 0.0282 0.0301 0.0323 0.0167 0.0173 0.0136
Germany 8734 0 0.9398 0.0174 0.0135 0.0084 0.0072 0.0073 0.0027 0.0037
Germany 8735 0 0.853 0.0417 0.0469 0.0111 0.0048 0.0155 0.0112 0.0158
Germany 8736 0 0.9326 0.019 0.0249 0.004 0.0043 0.006 0.004 0.0052
Germany 8737 2 0.9447 0.01 0.0089 0.0093 0.0085 0.0086 0.0042 0.0058
Germany 8738 10 0.8424 0.0646 0.0574 0.0086 0.0088 0.0097 0.0031 0.0054
Germany 8739 0 0.9201 0.0206 0.0394 0.0049 0.0039 0.0055 0.0021 0.0035
Germany 8741 12 0.0993 0.1491 0.7016 0.0089 0.0123 0.0205 0.0031 0.0052
Germany 8742 10 0.8989 0.0282 0.0222 0.0063 0.0079 0.0193 0.0117 0.0055
Germany 8744 6 0.5045 0.1384 0.2209 0.0039 0.01 0.0523 0.0603 0.0098
Germany 8745 22 0.9016 0.0364 0.0197 0.0071 0.0116 0.0142 0.0032 0.0062
Germany 8746 0 0.8691 0.0171 0.0171 0.0118 0.0437 0.025 0.0095 0.0067
Germany 8747 12 0.9586 0.0065 0.0069 0.004 0.0084 0.0081 0.0041 0.0034
Germany 8749 0 0.9421 0.0094 0.0083 0.0098 0.0077 0.0103 0.005 0.0074
Italy-Milan 8050 0 0.602 0.203 0.0706 0.0627 0.0118 0.0239 0.0174 0.0087
Italy-Milan 8057 1 0.5543 0.14 0.0371 0.0592 0.0589 0.0641 0.0616 0.0247
Italy-Milan 8060 0 0.6467 0.053 0.0189 0.1859 0.0132 0.0147 0.0584 0.0092
Italy-Milan 8061 2 0.6295 0.0815 0.0415 0.0086 0.0065 0.0403 0.1821 0.01
Italy-Milan 8062 1 0.2173 0.6024 0.1243 0.0111 0.0142 0.0139 0.0121 0.0047
Italy-Milan 8065 4 0.2969 0.6124 0.0434 0.0103 0.0101 0.0181 0.0037 0.0051
Italy-Milan 8066 0 0.1381 0.6217 0.1306 0.0407 0.0104 0.019 0.0315 0.008
Italy-Milan 8067 2 0.4805 0.2641 0.133 0.0413 0.007 0.0244 0.0376 0.0122
Italy-Milan 8068 0 0.3707 0.4037 0.1242 0.0138 0.0367 0.0319 0.0078 0.0111
Italy-Milan 8069 0 0.5977 0.1327 0.0543 0.0159 0.0155 0.1351 0.0308 0.0179
Italy-Milan 8071 2 0.6873 0.1343 0.0781 0.0153 0.0114 0.0309 0.0108 0.0318
Italy-Milan 8072 2 0.2072 0.2507 0.1594 0.0083 0.0245 0.0491 0.199 0.1017
Italy-Milan 8073 0 0.6913 0.0349 0.1821 0.0146 0.0145 0.048 0.0041 0.0106
Italy-Milan 8074 1 0.7195 0.0239 0.0693 0.0058 0.0104 0.0327 0.1294 0.009 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Italy-Rome 8586 1 0.4396 0.1849 0.2332 0.0171 0.0406 0.0685 0.0044 0.0118
Italy-Rome 8589 2 0.9124 0.0137 0.0244 0.0094 0.0088 0.0145 0.0083 0.0085
Italy-Rome 8592 1 0.3862 0.2207 0.0434 0.0751 0.0496 0.1617 0.0073 0.056
Italy-Rome 8594 1 0.7447 0.1067 0.0561 0.0071 0.0201 0.021 0.0161 0.0281
Italy-Rome 8595 0 0.6873 0.051 0.1204 0.0247 0.0268 0.0388 0.0332 0.0177
Italy-Rome 8596 1 0.2942 0.1279 0.481 0.0122 0.0055 0.063 0.0075 0.0088
Italy-Rome 8597 0 0.7674 0.0273 0.0603 0.0181 0.0133 0.0584 0.0332 0.0219
Italy-Rome 8599 0 0.9274 0.0083 0.0134 0.0072 0.0111 0.0111 0.013 0.0085
Italy-Rome 8601 2 0.5432 0.2255 0.1248 0.0126 0.0187 0.0143 0.0186 0.0423
Italy-Rome 8602 2 0.7002 0.0579 0.0404 0.0131 0.012 0.1561 0.0116 0.0087
Italy-Rome 8603 0 0.8695 0.0332 0.0264 0.0085 0.0066 0.0116 0.0165 0.0277
Italy-Rome 8604 2 0.1576 0.2738 0.4345 0.0077 0.0203 0.0174 0.0043 0.0843
Italy-Rome 8609 1 0.8883 0.0327 0.0297 0.0066 0.0104 0.0189 0.0048 0.0085
Italy-Rome 8610 1 0.385 0.2904 0.1399 0.0329 0.0272 0.0516 0.0195 0.0536
Italy-Rome 8611 2 0.6267 0.1049 0.1002 0.0186 0.0145 0.1139 0.0129 0.0083
Turkey 6477 2 0.7494 0.0419 0.0268 0.1058 0.035 0.0163 0.0152 0.0095
Turkey 6478 0 0.0803 0.4344 0.1166 0.0208 0.0151 0.1532 0.0122 0.1676
Turkey 6480 0 0.0088 0.1331 0.6852 0.0481 0.0197 0.0672 0.0294 0.0086
Turkey 6481 2 0.5551 0.0603 0.0425 0.006 0.1769 0.0823 0.0593 0.0175
Turkey 6482 3 0.7276 0.018 0.0275 0.0091 0.0089 0.0662 0.1312 0.0116
Turkey 6484 4 0.3921 0.3362 0.1122 0.0164 0.039 0.0732 0.0233 0.0076
Turkey 6486 1 0.7103 0.0467 0.0446 0.0456 0.0815 0.0353 0.0171 0.0189
Turkey 6487 4 0.6456 0.0329 0.0191 0.034 0.1001 0.1411 0.0187 0.0085
Turkey 6488 4 0.7409 0.0323 0.0184 0.0645 0.0394 0.0483 0.0281 0.0281
Turkey 6491 2 0.35 0.1655 0.105 0.0115 0.3306 0.0154 0.0094 0.0126
Turkey 6494 6 0.4972 0.1157 0.0744 0.0423 0.0358 0.0921 0.1229 0.0194
Turkey 6496 4 0.6051 0.0426 0.0421 0.0345 0.0257 0.0234 0.2017 0.0249
Turkey 6499 2 0.6808 0.0265 0.0377 0.0148 0.0379 0.124 0.0683 0.0099
Turkey 6500 1 0.4518 0.0472 0.0307 0.0451 0.3319 0.0737 0.0139 0.0057
Turkey 6502 4 0.5497 0.0364 0.0171 0.0339 0.0523 0.2541 0.0238 0.0327
Turkey 6503 4 0.5737 0.0299 0.031 0.0083 0.3192 0.0205 0.0097 0.0077
Turkey 6507 2 0.2732 0.0622 0.0209 0.007 0.0667 0.4754 0.0265 0.068
Turkey 6510 2 0.7601 0.0349 0.039 0.063 0.0315 0.0368 0.0253 0.0093
Turkey 6512 2 0.202 0.1712 0.0851 0.0909 0.0248 0.2593 0.1215 0.0451
Turkey 6513 4 0.2724 0.0715 0.0486 0.0246 0.0906 0.3703 0.0736 0.0485
Turkey 6514 4 0.4091 0.0938 0.0246 0.0141 0.316 0.0498 0.0698 0.0229
Turkey 6516 2 0.3466 0.1908 0.0483 0.0129 0.0244 0.2886 0.0674 0.0211
Turkey 6519 2 0.3946 0.0957 0.0172 0.0326 0.0557 0.3361 0.0216 0.0464
Turkey 6520 3 0.4668 0.1244 0.0515 0.0792 0.1229 0.0814 0.0576 0.0161
Turkey 6521 2 0.7308 0.105 0.0422 0.02 0.019 0.0549 0.019 0.0091
Turkey 6729 0 0.4579 0.0228 0.0212 0.0354 0.3831 0.0485 0.0119 0.0192
Turkey 6730 1 0.7362 0.0366 0.0376 0.0105 0.0759 0.0175 0.0251 0.0606
Turkey 6731 2 0.6791 0.0206 0.0183 0.0125 0.0566 0.1118 0.0396 0.0614
Turkey 6732 1 0.6 0.0921 0.0549 0.0515 0.0191 0.1021 0.0248 0.0556
Turkey 6733 1 0.5933 0.0173 0.0308 0.0119 0.0382 0.262 0.0391 0.0074
Turkey 6734 1 0.1613 0.0897 0.0354 0.0074 0.1713 0.4542 0.0357 0.045
Turkey 6735 1 0.2061 0.058 0.0414 0.0124 0.0153 0.6383 0.0141 0.0144
Turkey 6736 2 0.7785 0.0174 0.022 0.0098 0.1306 0.0143 0.0091 0.0183
Turkey 6738 2 0.6074 0.0168 0.021 0.0468 0.0848 0.0218 0.1739 0.0275
Turkey 6739 0 0.6749 0.0327 0.0206 0.0164 0.1628 0.0481 0.0092 0.0353
Turkey 6740 5 0.5768 0.025 0.0172 0.0248 0.0369 0.0204 0.2859 0.013
Turkey 6741 7 0.1037 0.4046 0.4554 0.0117 0.0072 0.0101 0.003 0.0043
Turkey 6742 12 0.0268 0.1655 0.5709 0.0336 0.1129 0.04 0.0145 0.0359
Turkey 6743 11 0.0125 0.7056 0.2448 0.009 0.0066 0.0131 0.0041 0.0043
Turkey 6745 12 0.0191 0.036 0.023 0.0271 0.1568 0.2601 0.4483 0.0297
Turkey 6746 14 0.0255 0.3924 0.5028 0.0046 0.0463 0.0074 0.0033 0.0176 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Turkey 6748 7 0.0347 0.637 0.2716 0.0067 0.0156 0.0175 0.0082 0.0086
Turkey 6749 8 0.5575 0.2392 0.0994 0.0114 0.0476 0.027 0.0099 0.008
Turkey 6750 15 0.1611 0.4095 0.3553 0.0091 0.0127 0.0304 0.0048 0.0171
Turkey 6753 12 0.0288 0.405 0.4555 0.0392 0.0101 0.0286 0.0041 0.0287
Turkey 6754 15 0.0058 0.0079 0.0078 0.0338 0.5464 0.0173 0.3679 0.0131
Turkey 6755 11 0.1046 0.4561 0.2677 0.0321 0.0123 0.0745 0.0308 0.0219
Turkey 6756 12 0.0218 0.6947 0.193 0.0139 0.0191 0.0177 0.0153 0.0245
Turkey 6758 12 0.4593 0.3022 0.1461 0.0142 0.009 0.043 0.0089 0.0172
Turkey 6759 15 0.0881 0.6066 0.154 0.0211 0.0945 0.0106 0.004 0.0211
Turkey 6760 6 0.0683 0.3367 0.3902 0.0476 0.0468 0.0593 0.0115 0.0396
Cyprus 10128 1 0.0529 0.6925 0.2097 0.011 0.0054 0.017 0.0047 0.0068
Cyprus 10129 14 0.0154 0.7548 0.1735 0.0081 0.0113 0.0143 0.0067 0.016
Cyprus 10130 10 0.0153 0.1691 0.5096 0.012 0.1362 0.0238 0.1032 0.0309
Cyprus 10131 15 0.0505 0.7148 0.0468 0.1358 0.0149 0.0193 0.004 0.0139
Cyprus 10132 14 0.6346 0.1209 0.1012 0.0248 0.0249 0.061 0.0129 0.0195
Cyprus 10133 9 0.008 0.0136 0.0101 0.0093 0.0109 0.0109 0.9332 0.004
Cyprus 10134 12 0.9429 0.0101 0.0127 0.0065 0.0077 0.0083 0.0057 0.0061
Cyprus 10135 7 0.2713 0.4963 0.069 0.0471 0.0326 0.0256 0.0073 0.0508
Cyprus 10136 15 0.1118 0.3276 0.4577 0.0424 0.015 0.0291 0.0044 0.0119
Cyprus 10137 12 0.4979 0.375 0.0541 0.0105 0.0115 0.0244 0.0055 0.0211
Cyprus 10138 1 0.0484 0.0878 0.0213 0.5443 0.0482 0.1812 0.011 0.0578
Cyprus 10139 1 0.0171 0.5866 0.3635 0.0056 0.0112 0.0087 0.0032 0.0041
Cyprus 10140 2 0.1454 0.6382 0.1156 0.0224 0.0343 0.0245 0.0077 0.0119
Cyprus 10141 0 0.011 0.3811 0.4365 0.0197 0.0261 0.0685 0.0329 0.0243
Cyprus 10142 3 0.0155 0.69 0.21 0.014 0.0278 0.0197 0.0083 0.0147
Cyprus 10143 0 0.0095 0.6003 0.2972 0.0532 0.0097 0.0131 0.0102 0.0069
Cyprus 10144 2 0.011 0.5562 0.4086 0.0064 0.0047 0.0066 0.0027 0.0038
Cyprus 10145 1 0.1119 0.6666 0.1659 0.012 0.019 0.0147 0.0039 0.006
Cyprus 10146 2 0.0626 0.714 0.2033 0.0031 0.0062 0.0061 0.0018 0.0029
Cyprus 10147 2 0.2089 0.411 0.1097 0.0156 0.0224 0.2223 0.0046 0.0055
Cyprus 10148 0 0.9578 0.0103 0.0061 0.0056 0.0073 0.0055 0.003 0.0044
Cyprus 10149 0 0.0991 0.0105 0.0218 0.0139 0.0333 0.0126 0.7939 0.0149
Cyprus 10150 2 0.0999 0.7136 0.0788 0.0547 0.0123 0.0206 0.0083 0.0119
Cyprus 10151 1 0.1075 0.3023 0.5569 0.0056 0.0078 0.0101 0.0058 0.0041
Cyprus 10152 0 0.0256 0.4862 0.407 0.0229 0.0314 0.0089 0.0034 0.0147
Cyprus 10153 1 0.0887 0.1397 0.0314 0.0372 0.0548 0.4654 0.0749 0.1077
Cyprus 10154 1 0.0771 0.1913 0.1746 0.0214 0.3335 0.1737 0.0149 0.0134
Cyprus 10155 0 0.0231 0.1207 0.7555 0.0115 0.0318 0.0397 0.0085 0.0092
Cyprus 10156 3 0.2038 0.6156 0.1279 0.0083 0.0096 0.0162 0.009 0.0097
Cyprus 10157 0 0.2116 0.3524 0.3623 0.0318 0.0071 0.0152 0.0056 0.014
Lebanon 10235 2 0.1141 0.7295 0.0705 0.0221 0.0221 0.0106 0.0072 0.0239
Lebanon 10236 1 0.131 0.3684 0.4463 0.018 0.0122 0.0119 0.003 0.0092
Lebanon 10237 0 0.0692 0.6794 0.2001 0.0059 0.0161 0.0161 0.0044 0.0088
Lebanon 10238 1 0.0431 0.5284 0.3114 0.0057 0.0118 0.0724 0.0113 0.0159
Lebanon 10239 2 0.3051 0.3118 0.2237 0.0234 0.0639 0.0542 0.0051 0.0129
Lebanon 10240 1 0.3692 0.5016 0.0435 0.0372 0.0281 0.0076 0.0033 0.0095
Lebanon 10241 3 0.029 0.1906 0.5794 0.0148 0.0082 0.1375 0.0108 0.0297
Lebanon 10242 0 0.5443 0.1975 0.0467 0.0775 0.0139 0.0505 0.0271 0.0425
Lebanon 10243 2 0.0346 0.2644 0.6365 0.0048 0.0071 0.0436 0.0039 0.0052
Lebanon 10244 1 0.2191 0.2947 0.1575 0.018 0.0127 0.0572 0.0227 0.218
Lebanon 10245 0 0.0041 0.3287 0.4552 0.0401 0.0217 0.0702 0.0564 0.0237
Lebanon 10246 0 0.0761 0.1966 0.5194 0.0081 0.0108 0.0996 0.0665 0.0229
Lebanon 10247 0 0.1617 0.422 0.3287 0.0142 0.0243 0.0291 0.0079 0.0121
Lebanon 10248 2 0.0695 0.3312 0.3294 0.0517 0.129 0.0701 0.0078 0.0113
Lebanon 10249 2 0.2897 0.351 0.136 0.1631 0.0205 0.0223 0.0041 0.0133
Lebanon 10250 1 0.0175 0.6093 0.3216 0.0079 0.0056 0.0276 0.0046 0.0059 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Lebanon 10251 2 0.0074 0.4529 0.4552 0.0124 0.0128 0.022 0.0275 0.0098
Lebanon 10252 3 0.0315 0.531 0.3055 0.0125 0.0184 0.0215 0.022 0.0576
Lebanon 10253 0 0.0272 0.4327 0.4627 0.0071 0.0093 0.022 0.0125 0.0265
Lebanon 10254 0 0.013 0.4075 0.5161 0.0055 0.0076 0.0395 0.0041 0.0067
Lebanon 10255 1 0.0163 0.7811 0.1209 0.0242 0.0105 0.0153 0.0235 0.0082
Lebanon 10256 0 0.0067 0.6663 0.2554 0.007 0.008 0.0226 0.0066 0.0274
Lebanon 10257 2 0.0156 0.3061 0.2404 0.0953 0.1756 0.1349 0.0158 0.0162
Lebanon 10258 1 0.0441 0.2025 0.5791 0.0117 0.0319 0.1051 0.0089 0.0167
Lebanon 10259 0 0.0136 0.1684 0.5525 0.1331 0.0783 0.0418 0.0031 0.0092
Lebanon 10260 1 0.0325 0.7087 0.1834 0.0113 0.0249 0.0138 0.005 0.0204
Lebanon 10261 0 0.0256 0.4343 0.4421 0.0176 0.0225 0.0318 0.0139 0.0121
Lebanon 10262 2 0.0174 0.1123 0.6791 0.0286 0.0205 0.1162 0.0173 0.0086
Lebanon 10263 0 0.0822 0.5951 0.2266 0.0146 0.0099 0.0179 0.0154 0.0383
Lebanon 10264 2 0.0098 0.1393 0.6933 0.0094 0.0194 0.1066 0.0096 0.0126
Lebanon 10265 2 0.2518 0.5535 0.1258 0.0343 0.0118 0.0121 0.0031 0.0075
Lebanon 10266 1 0.0121 0.6189 0.2274 0.0184 0.0179 0.0114 0.0036 0.0903
Lebanon 10267 2 0.0145 0.0925 0.7665 0.01 0.008 0.0768 0.02 0.0117
Lebanon 10268 2 0.0086 0.7006 0.2164 0.007 0.0246 0.0201 0.0127 0.01
Lebanon 10270 5 0.0078 0.2784 0.5489 0.0671 0.0104 0.0696 0.0105 0.0073
Lebanon 10271 2 0.0592 0.1565 0.4237 0.2265 0.0317 0.0822 0.0117 0.0085
Lebanon 10273 21 0.0179 0.2355 0.3902 0.0298 0.0393 0.2248 0.0227 0.0397
Lebanon 10274 25 0.0083 0.1596 0.3479 0.011 0.1331 0.2895 0.0055 0.0451
Lebanon 10276 19 0.0122 0.4411 0.2162 0.0271 0.0447 0.0813 0.0266 0.1508
Lebanon 10277 2 0.2434 0.1635 0.3474 0.0265 0.0294 0.1519 0.016 0.0219
Lebanon 10278 16 0.0202 0.5363 0.2975 0.0299 0.0435 0.057 0.0053 0.0102
Lebanon 10279 20 0.0225 0.4778 0.3676 0.0301 0.0219 0.0557 0.0103 0.0141
Lebanon 10280 5 0.0196 0.3098 0.3519 0.1155 0.0146 0.0971 0.0159 0.0755
Lebanon 10281 0 0.0866 0.43 0.3027 0.0157 0.0121 0.0371 0.0903 0.0254
Lebanon 10282 1 0.0189 0.6503 0.1991 0.0636 0.0129 0.0302 0.01 0.0149
Lebanon 10283 18 0.0201 0.2162 0.4903 0.0206 0.0243 0.1927 0.0096 0.0263
Lebanon 10284 6 0.0176 0.6474 0.1881 0.0504 0.0498 0.0254 0.0124 0.0089
Lebanon 10285 18 0.1226 0.3423 0.3331 0.0904 0.009 0.0365 0.0479 0.0183
Lebanon 10286 26 0.0077 0.2736 0.5223 0.0707 0.0479 0.0337 0.019 0.0251
Lebanon 10287 22 0.0129 0.2714 0.2604 0.02 0.334 0.0452 0.0188 0.0372
Lebanon 10288 18 0.2136 0.5667 0.1054 0.0121 0.0206 0.0586 0.0122 0.0108
Lebanon 10289 27 0.0223 0.6432 0.267 0.0126 0.0128 0.0268 0.0061 0.0093
Lebanon 10290 4 0.0102 0.6603 0.1905 0.0261 0.0335 0.0558 0.0079 0.0156
Lebanon 10291 14 0.1626 0.2685 0.1163 0.2976 0.0265 0.0856 0.027 0.0158
Lebanon 10292 4 0.0066 0.0454 0.0192 0.1971 0.65 0.0187 0.0473 0.0157
Lebanon 10294 13 0.0168 0.5621 0.2948 0.0095 0.0255 0.0324 0.0068 0.0521
Lebanon 10295 7 0.0554 0.2153 0.4258 0.1033 0.0102 0.096 0.0685 0.0255
Lebanon 10297 10 0.0786 0.3293 0.1791 0.156 0.1776 0.0507 0.0119 0.0168
Lebanon 10298 3 0.3815 0.0979 0.3208 0.0101 0.0094 0.0492 0.1168 0.0143
Lebanon 10299 19 0.0086 0.2198 0.4538 0.0589 0.0289 0.0341 0.0202 0.1758
Lebanon 10300 0 0.0235 0.0561 0.3501 0.0066 0.012 0.021 0.4725 0.0582
Israel 4962 17 0.1057 0.4387 0.3541 0.0149 0.0081 0.0578 0.0113 0.0094
Israel 4963 14 0.0091 0.4248 0.4223 0.014 0.0071 0.0206 0.0623 0.0398
Israel 4964 22 0.0062 0.6755 0.2503 0.0322 0.009 0.0094 0.0061 0.0113
Israel 4966 2 0.0324 0.2986 0.4524 0.0784 0.0601 0.051 0.0117 0.0153
Israel 4967 3 0.0829 0.5028 0.2313 0.0468 0.0219 0.0598 0.0133 0.0413
Israel 4968 10 0.0151 0.0844 0.7741 0.0154 0.0114 0.0789 0.0096 0.0111
Israel 4969 5 0.0059 0.2667 0.5593 0.0108 0.0091 0.0928 0.0261 0.0293
Israel 4970 12 0.8446 0.0281 0.0221 0.0303 0.0512 0.009 0.0076 0.0071
Israel 4971 17 0.0191 0.1511 0.6555 0.0163 0.0361 0.0249 0.0421 0.0549
Israel 4972 10 0.1452 0.183 0.2077 0.015 0.0226 0.0246 0.3872 0.0148
Israel 4973 1 0.0109 0.1992 0.4756 0.0889 0.0718 0.0411 0.0899 0.0226 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Israel 4974 4 0.0353 0.3558 0.3084 0.0231 0.0086 0.0229 0.045 0.2008
Israel 4975 3 0.0846 0.1692 0.6612 0.0056 0.0122 0.0406 0.0077 0.019
Israel 4976 4 0.0101 0.6943 0.2099 0.0369 0.0266 0.0095 0.0043 0.0085
Israel 4977 4 0.1199 0.4947 0.1893 0.0186 0.0077 0.0857 0.0299 0.0542
Israel 4978 3 0.0138 0.1679 0.6089 0.1524 0.0127 0.0187 0.0057 0.0198
Israel 4979 2 0.0249 0.6712 0.1467 0.0868 0.0192 0.0267 0.0078 0.0167
Israel 4980 2 0.0254 0.1236 0.6685 0.0217 0.0292 0.0681 0.0209 0.0426
Israel 4981 7 0.0324 0.6631 0.2448 0.0095 0.0177 0.0128 0.0064 0.0133
Israel 4982 2 0.0311 0.1899 0.5462 0.0155 0.0111 0.0664 0.066 0.0738
Israel 4983 16 0.0086 0.0816 0.7355 0.02 0.063 0.0747 0.0054 0.0113
Israel 4984 14 0.0372 0.0939 0.6094 0.1373 0.0102 0.0654 0.0164 0.0303
Israel 4985 1 0.0111 0.0972 0.7576 0.0152 0.0359 0.0681 0.0118 0.0031
Israel 4986 3 0.1134 0.2036 0.1339 0.0376 0.0307 0.2596 0.086 0.1351
Israel 4988 1 0.2149 0.0893 0.5612 0.0422 0.0088 0.0399 0.0102 0.0336
Israel 4989 25 0.2301 0.2447 0.1459 0.0268 0.0329 0.1 0.0166 0.2031
Israel 4990 2 0.0083 0.6561 0.2341 0.0357 0.0149 0.021 0.0095 0.0204
Israel 4992 3 0.0203 0.422 0.3707 0.039 0.0174 0.0941 0.0133 0.0232
Israel 4993 8 0.0377 0.3123 0.3383 0.038 0.1205 0.1062 0.0146 0.0323
Israel 4994 6 0.0371 0.4967 0.1587 0.0202 0.14 0.1128 0.0268 0.0076
Israel 4995 9 0.0151 0.4571 0.364 0.0107 0.0117 0.0213 0.0821 0.038
Israel 4996 6 0.0611 0.1476 0.4386 0.0629 0.013 0.1088 0.092 0.076
Israel 4997 5 0.0482 0.1031 0.4904 0.1692 0.0275 0.1271 0.0174 0.0171
Israel 4998 7 0.0124 0.0487 0.7184 0.0374 0.0448 0.1138 0.0077 0.0169
Israel 5000 20 0.0857 0.1338 0.5661 0.0637 0.0303 0.0858 0.0204 0.0142
Israel 5001 25 0.0256 0.4044 0.3805 0.0392 0.0425 0.0704 0.0173 0.0202
Israel 5002 0 0.1693 0.1751 0.2846 0.0633 0.2199 0.0534 0.0054 0.029
Israel 5003 0 0.0578 0.2144 0.3998 0.011 0.0883 0.2096 0.005 0.0141
Israel 5004 0 0.0088 0.2362 0.4943 0.1704 0.0097 0.0501 0.0172 0.0132
Israel 5005 2 0.0187 0.1387 0.7404 0.0098 0.0382 0.0349 0.0084 0.0109
Israel 5006 1 0.1279 0.4641 0.1387 0.0929 0.1334 0.0243 0.0116 0.0072
Israel 5007 2 0.0073 0.0527 0.7963 0.0172 0.0085 0.086 0.012 0.02
Israel 5008 1 0.6522 0.0283 0.0259 0.019 0.0133 0.0824 0.102 0.0769
Israel 5009 0 0.0301 0.3734 0.505 0.0155 0.0111 0.0265 0.0166 0.0218
Israel 5010 0 0.0104 0.3837 0.5676 0.0137 0.0068 0.0068 0.005 0.006
Israel 5011 0 0.0442 0.2644 0.4944 0.0695 0.0179 0.0141 0.0126 0.083
Egypt-Cairo 8190 2 0.0229 0.3802 0.3973 0.018 0.1106 0.0319 0.0131 0.026
Egypt-Cairo 8192 1 0.0234 0.2141 0.5805 0.0239 0.0155 0.1101 0.0097 0.0228
Egypt-Cairo 8193 0 0.0402 0.5017 0.3644 0.0209 0.0121 0.035 0.012 0.0137
Egypt-Cairo 8196 0 0.0628 0.1656 0.4636 0.1446 0.0721 0.0291 0.0314 0.0307
Egypt-Cairo 8203 0 0.2673 0.175 0.2104 0.169 0.0268 0.132 0.0099 0.0095
Egypt-Cairo 8215 1 0.0156 0.3212 0.3801 0.0625 0.1323 0.0383 0.0126 0.0373
Egypt-Cairo 8198 1 0.0215 0.3737 0.2784 0.1419 0.1073 0.026 0.017 0.0341
Egypt-Cairo 8194 1 0.1308 0.3771 0.3105 0.015 0.1322 0.0195 0.0063 0.0086
Egypt-Cairo 8211 2 0.0612 0.0647 0.1698 0.0381 0.0099 0.0956 0.0255 0.5353
Egypt-Cairo 8216 3 0.0196 0.058 0.5911 0.0189 0.0144 0.2778 0.0117 0.0085
Egypt-Cairo 8195 0 0.0451 0.3903 0.2232 0.0341 0.116 0.0949 0.06 0.0363
Egypt-Cairo 8199 2 0.083 0.5569 0.1061 0.0628 0.1049 0.0495 0.0243 0.0126
Egypt-Cairo 8200 16 0.0533 0.1033 0.7252 0.0127 0.0073 0.0533 0.0084 0.0364
Egypt-Cairo 8201 1 0.0246 0.3423 0.352 0.0326 0.0172 0.1288 0.0899 0.0126
Egypt-Cairo 8202 0 0.0434 0.1732 0.5444 0.0133 0.0163 0.1345 0.0449 0.03
Egypt-Cairo 8204 4 0.0525 0.2221 0.4149 0.0127 0.0049 0.0999 0.0801 0.1129
Egypt-Cairo 8208 2 0.0207 0.0595 0.321 0.0153 0.015 0.139 0.1903 0.2391
Egypt-Cairo 8210 6 0.0249 0.4847 0.185 0.1692 0.0968 0.0153 0.0043 0.0199
Egypt-Cairo 8214 10 0.0194 0.3837 0.4908 0.0224 0.0316 0.0164 0.0181 0.0176
Egypt-Cairo 8191 2 0.0068 0.6047 0.3252 0.0076 0.0098 0.0347 0.0052 0.006
Egypt-Cairo 8197 1 0.0602 0.1212 0.4084 0.0076 0.0053 0.0931 0.113 0.1912 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Egypt-Cairo 8205 0 0.0127 0.2425 0.5066 0.0131 0.0063 0.0902 0.007 0.1216
Egypt-Cairo 8206 0 0.0198 0.1813 0.4052 0.0195 0.0065 0.1075 0.1409 0.1194
Egypt-Cairo 8207 0 0.1309 0.2393 0.2543 0.2481 0.0459 0.0593 0.0089 0.0132
Egypt-Cairo 8209 1 0.0111 0.5614 0.3539 0.0156 0.0103 0.03 0.0065 0.0112
Egypt-Cairo 8212 1 0.2888 0.1058 0.4111 0.0079 0.0376 0.0954 0.02 0.0334
Egypt-Cairo 8213 0 0.0286 0.4116 0.3308 0.0053 0.0328 0.1381 0.0377 0.0151
Egypt-Cairo 9942 1 0.2027 0.1753 0.0885 0.1089 0.0375 0.1801 0.1496 0.0574
Egypt-Cairo 9943 0 0.0094 0.078 0.567 0.1313 0.0198 0.0831 0.0815 0.03
Egypt-Cairo 9944 0 0.0965 0.5944 0.225 0.0099 0.0247 0.0307 0.0045 0.0143
Egypt-Cairo 9945 1 0.0506 0.0897 0.655 0.0677 0.0131 0.0945 0.0199 0.0094
Egypt-Cairo 9946 1 0.0132 0.3816 0.3723 0.0148 0.0542 0.0428 0.0532 0.0678
Egypt-Cairo 9947 0 0.1948 0.2128 0.3182 0.0204 0.1216 0.0341 0.063 0.0351
Egypt-Cairo 9948 0 0.0145 0.3067 0.2668 0.0735 0.0161 0.0392 0.2709 0.0124
Egypt-Cairo 9949 1 0.0135 0.7171 0.2183 0.0157 0.0112 0.016 0.0035 0.0047
Egypt-Cairo 9950 0 0.0068 0.2971 0.5737 0.013 0.008 0.064 0.0095 0.0279
Egypt-Cairo 9951 0 0.0175 0.0427 0.7607 0.0215 0.006 0.1108 0.0208 0.02
Egypt-Cairo 9952 2 0.066 0.611 0.2515 0.0089 0.0253 0.0236 0.0067 0.007
Egypt-Cairo 9953 0 0.2966 0.0623 0.485 0.0529 0.0145 0.0446 0.0209 0.0233
Egypt-Cairo 9954 1 0.0129 0.3399 0.4646 0.0399 0.0519 0.0433 0.0196 0.028
Egypt-Cairo 9955 1 0.0111 0.6656 0.28 0.0086 0.0068 0.0179 0.0048 0.0052
Egypt-Cairo 9956 1 0.0357 0.4529 0.1909 0.03 0.0188 0.2412 0.0107 0.0198
Egypt-Cairo 9957 2 0.0117 0.1107 0.7133 0.0175 0.0103 0.1064 0.0205 0.0096
Egypt-Cairo 9958 0 0.0325 0.0562 0.7217 0.0261 0.0109 0.1188 0.0214 0.0124
Egypt-Cairo 9959 10 0.0144 0.157 0.7767 0.0081 0.0081 0.0258 0.0034 0.0065
Egypt-Cairo 9960 1 0.0165 0.0877 0.7731 0.0106 0.0113 0.0271 0.0687 0.0049
Egypt-Cairo 9961 1 0.0943 0.0716 0.7391 0.0127 0.0355 0.0323 0.0051 0.0095
Egypt-Cairo 9962 9 0.0259 0.465 0.3561 0.0105 0.0193 0.0979 0.0056 0.0197
Egypt-Cairo 9963 16 0.0193 0.0765 0.8057 0.0117 0.0081 0.0601 0.0094 0.0091
Egypt-Cairo 9964 0 0.1236 0.1321 0.5508 0.0213 0.0188 0.0839 0.0618 0.0077
Egypt-Cairo 10021 2 0.0135 0.1514 0.0451 0.0527 0.0406 0.1013 0.57 0.0253
Egypt-Cairo 10022 2 0.0122 0.1959 0.6576 0.005 0.0091 0.1049 0.0041 0.0112
Egypt-Cairo 10023 0 0.005 0.0735 0.778 0.0616 0.0101 0.0563 0.01 0.0054
Egypt-Cairo 10024 3 0.0169 0.4188 0.3592 0.0376 0.0317 0.0431 0.0067 0.0859
Egypt-Cairo 10025 2 0.0198 0.5359 0.1328 0.035 0.0093 0.1445 0.1099 0.0128
Egypt-Cairo 10026 1 0.009 0.6837 0.2687 0.0071 0.0049 0.0138 0.0061 0.0067
Egypt-Cairo 10027 0 0.0147 0.2904 0.6285 0.0065 0.0196 0.0159 0.0194 0.0051
Egypt-Cairo 10028 0 0.0051 0.232 0.5443 0.1234 0.0096 0.0457 0.0042 0.0357
Egypt-Cairo 10029 1 0.0041 0.3348 0.5404 0.0218 0.0103 0.0487 0.0144 0.0256
Egypt-Cairo 10030 2 0.0092 0.0484 0.7438 0.0126 0.0088 0.1259 0.0372 0.0141
Egypt-Cairo 10031 1 0.0057 0.3257 0.5443 0.037 0.0064 0.0623 0.0064 0.0122
Egypt-Cairo 10032 0 0.0187 0.4441 0.3494 0.0245 0.0217 0.0899 0.045 0.0068
Egypt-Cairo 10033 0 0.0185 0.4404 0.3175 0.0151 0.0204 0.16 0.0194 0.0088
Egypt-Cairo 10034 3 0.0137 0.0783 0.8012 0.013 0.0476 0.0211 0.0067 0.0184
Egypt-Cairo 10035 0 0.1083 0.0724 0.4031 0.0059 0.008 0.0392 0.3585 0.0047
Egypt-Cairo 10037 4 0.5388 0.026 0.0306 0.1271 0.0983 0.1358 0.0206 0.0228
Egypt-Cairo 10042 0 0.0041 0.0523 0.7491 0.0206 0.0284 0.1233 0.0133 0.0089
Egypt-Cairo 10043 0 0.0141 0.268 0.65 0.008 0.0083 0.0268 0.0099 0.0148
Egypt-Cairo 10044 2 0.0069 0.2254 0.5655 0.0438 0.1039 0.0325 0.0138 0.0082
Egypt-Cairo 10045 0 0.0585 0.5482 0.3471 0.0091 0.005 0.0189 0.0084 0.0049
Egypt-Cairo 10046 0 0.0134 0.1061 0.591 0.009 0.0083 0.1383 0.1093 0.0246
Egypt-Cairo 10047 1 0.0273 0.0925 0.8261 0.0058 0.0048 0.0342 0.0033 0.0061
Egypt-Cairo 10048 2 0.01 0.1433 0.6051 0.0463 0.0112 0.1426 0.0303 0.0112
Egypt-Cairo 10083 1 0.0043 0.2661 0.478 0.1238 0.0798 0.0342 0.0049 0.0089
Egypt-Cairo 10040 4 0.6381 0.0808 0.0771 0.0312 0.0114 0.0909 0.0394 0.031
Egypt-Cairo 10041 0 0.0085 0.0254 0.4525 0.0067 0.0123 0.045 0.4357 0.014
Egypt-Cairo 10049 3 0.1062 0.4291 0.2275 0.0175 0.0533 0.1448 0.0119 0.0097 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Egypt-Cairo 10084 5 0.0095 0.0359 0.6399 0.0065 0.0182 0.0409 0.1638 0.0853
Egypt-Cairo 10085 1 0.1073 0.3931 0.2318 0.1681 0.024 0.0328 0.0105 0.0324
Egypt-Cairo 10087 1 0.0108 0.1416 0.6616 0.0217 0.0101 0.0382 0.1055 0.0105
Egypt-Cairo 10090 2 0.0123 0.0163 0.0292 0.0152 0.0378 0.8679 0.0111 0.0102
Egypt-Cairo 9968 1 0.0063 0.0512 0.8014 0.018 0.0099 0.0823 0.0203 0.0106
Egypt-Asuit 10091 5 0.0129 0.1401 0.2491 0.0189 0.0152 0.0851 0.388 0.0908
Egypt-Asuit 10093 2 0.0676 0.021 0.8179 0.0051 0.0199 0.0263 0.0338 0.0085
Egypt-Asuit 10094 4 0.015 0.0678 0.8376 0.0111 0.0079 0.0307 0.0109 0.0191
Egypt-Asuit 10095 2 0.0176 0.491 0.2695 0.0278 0.0364 0.0882 0.0542 0.0152
Egypt-Asuit 10096 8 0.0125 0.0991 0.8423 0.0092 0.012 0.0125 0.0078 0.0045
Egypt-Asuit 10098 1 0.0062 0.0283 0.9124 0.0137 0.0096 0.0158 0.0062 0.0078
Egypt-Asuit 10099 0 0.0057 0.5676 0.3607 0.0357 0.0065 0.0125 0.0063 0.005
Egypt-Asuit 10100 2 0.0065 0.0379 0.9349 0.0037 0.0032 0.0082 0.0024 0.0032
Egypt-Asuit 10101 2 0.011 0.4772 0.3538 0.0563 0.0174 0.0473 0.0131 0.024
Egypt-Asuit 10102 21 0.0412 0.0342 0.8202 0.0075 0.0062 0.0494 0.0104 0.0309
Egypt-Luxor 10038 1 0.0095 0.1167 0.8346 0.0083 0.0055 0.0114 0.0069 0.0071
Egypt-Luxor 10039 1 0.0339 0.5228 0.4006 0.01 0.0098 0.0112 0.0041 0.0076
Egypt-Luxor 10050 4 0.0158 0.3732 0.5702 0.011 0.0076 0.0102 0.0057 0.0063
Egypt-Luxor 10051 1 0.0052 0.0362 0.9234 0.0064 0.0043 0.0137 0.0048 0.006
Egypt-Luxor 10052 3 0.0067 0.0409 0.9124 0.0063 0.0075 0.0106 0.0054 0.0102
Egypt-Luxor 10053 0 0.0124 0.3867 0.5491 0.0155 0.0093 0.0133 0.0065 0.0072
Egypt-Luxor 10054 1 0.0059 0.568 0.358 0.0358 0.0066 0.0136 0.007 0.0051
Egypt-Luxor 10055 1 0.0269 0.451 0.4258 0.01 0.0132 0.0582 0.0057 0.0092
Egypt-Luxor 10056 4 0.0147 0.3087 0.4245 0.0779 0.012 0.1329 0.0075 0.0218
Egypt-Luxor 10057 5 0.2909 0.0629 0.5261 0.0169 0.0193 0.061 0.0059 0.017
Egypt-Luxor 10058 1 0.0606 0.0554 0.7784 0.0078 0.0368 0.0273 0.0109 0.0228
Egypt-Luxor 10060 1 0.0241 0.13 0.7326 0.0325 0.0454 0.021 0.0072 0.0072
Egypt-Luxor 10061 4 0.016 0.2821 0.5926 0.0196 0.0094 0.0149 0.0101 0.0553
Egypt-Luxor 10062 1 0.0528 0.5586 0.3523 0.0058 0.0063 0.0149 0.0037 0.0055
Egypt-Luxor 10063 0 0.0102 0.3006 0.6085 0.0177 0.0096 0.0312 0.0099 0.0123
Egypt-Luxor 10064 0 0.0064 0.0237 0.9192 0.013 0.0083 0.0162 0.0068 0.0064
Egypt-Luxor 10065 1 0.0072 0.4304 0.3769 0.0263 0.0203 0.0625 0.0287 0.0477
Egypt-Luxor 10066 25 0.0228 0.1488 0.7166 0.0218 0.0294 0.0103 0.0055 0.0449
Egypt-Luxor 10067 3 0.0104 0.0919 0.7963 0.02 0.0112 0.0471 0.0078 0.0154
Egypt-Luxor 10068 1 0.0053 0.3155 0.4241 0.0822 0.0534 0.0914 0.0058 0.0223
Egypt-Luxor 10069 10 0.0136 0.394 0.2434 0.0086 0.0143 0.3002 0.0133 0.0126
Egypt-Luxor 10070 8 0.0386 0.0718 0.8112 0.0063 0.0337 0.0091 0.0164 0.0129
Egypt-Luxor 10071 18 0.0218 0.2886 0.6104 0.0046 0.0379 0.0169 0.0153 0.0046
Egypt-Luxor 10072 4 0.057 0.115 0.7388 0.0104 0.0559 0.0116 0.0031 0.0082
Egypt-Luxor 10073 3 0.046 0.0773 0.6397 0.0144 0.1639 0.0411 0.0107 0.007
Egypt-Luxor 10074 0 0.0141 0.0676 0.6902 0.0105 0.0886 0.0962 0.0052 0.0276
Egypt-Luxor 10079 1 0.01 0.0313 0.8109 0.0064 0.0078 0.1212 0.0041 0.0083
Egypt-Luxor 10080 4 0.0202 0.0154 0.9187 0.0041 0.0043 0.0279 0.0035 0.0059
Egypt-Abu Simbel 10076 4 0.0226 0.0287 0.8049 0.0065 0.0137 0.1095 0.0052 0.0089
Egypt-Abu Simbel 10077 16 0.0834 0.0704 0.7314 0.0072 0.0141 0.0732 0.0097 0.0107
Egypt-Abu Simbel 10081 2 0.0147 0.0333 0.7654 0.0052 0.0132 0.1181 0.0074 0.0427
Egypt-Abu Simbel 10089 2 0.0313 0.0115 0.9013 0.0041 0.0061 0.0382 0.0033 0.0041
Egypt-Abu Simbel 10092 0 0.0109 0.0178 0.9023 0.0066 0.0115 0.0394 0.003 0.0085
Iraq-West 9587 2 0.0806 0.076 0.6246 0.0115 0.091 0.0491 0.0236 0.0435
Iraq-West 10202 2 0.0064 0.0166 0.8825 0.0103 0.0111 0.0563 0.0083 0.0084
Iraq-West 10204 2 0.0082 0.0809 0.8137 0.0069 0.0067 0.0688 0.0054 0.0094
Iraq-West 11854 1 0.0081 0.0965 0.6933 0.0072 0.0674 0.0967 0.0215 0.0094
Iraq-West 11860 6 0.0051 0.0147 0.9229 0.0051 0.0043 0.0223 0.0129 0.0127
Iraq-West 11861 2 0.0059 0.0491 0.8123 0.0101 0.0055 0.0885 0.0143 0.0143
Iraq-West 11863 1 0.0063 0.0338 0.8286 0.0084 0.0142 0.0583 0.0079 0.0425
Iraq-West 11864 14 0.0117 0.045 0.8229 0.0047 0.0194 0.0662 0.011 0.0191 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iraq-West 11888 3 0.0058 0.0677 0.5868 0.0691 0.0575 0.0915 0.0301 0.0914
Iraq-West 11889 2 0.0063 0.2702 0.653 0.0228 0.0179 0.0152 0.004 0.0106
Iraq-West 11890 2 0.0044 0.0586 0.8357 0.0095 0.0112 0.028 0.0301 0.0225
Iraq-West 11891 2 0.0343 0.1488 0.6589 0.0119 0.0251 0.0838 0.0228 0.0143
Iraq-Baghdad 11847 13 0.0152 0.216 0.6415 0.0071 0.0071 0.0929 0.0037 0.0165
Iraq-Baghdad 11848 8 0.0152 0.1072 0.7644 0.024 0.0099 0.0587 0.0072 0.0134
Iraq-Baghdad 11849 5 0.0203 0.1896 0.7205 0.0054 0.0185 0.0287 0.0085 0.0085
Iraq-Baghdad 11850 0 0.0202 0.0986 0.8189 0.0056 0.0128 0.0116 0.0198 0.0125
Iraq-Baghdad 11852 3 0.0117 0.0731 0.803 0.0288 0.0166 0.0554 0.0051 0.0063
Iraq-Baghdad 11853 0 0.199 0.2937 0.1206 0.026 0.0482 0.2737 0.0104 0.0283
Iraq-Baghdad 11855 1 0.082 0.2489 0.5995 0.0068 0.0125 0.038 0.0061 0.0062
Iraq-Baghdad 11856 0 0.0126 0.0754 0.6803 0.0336 0.0318 0.134 0.0121 0.0202
Iraq-Baghdad 11857 4 0.0202 0.2615 0.5334 0.0073 0.0176 0.1268 0.0181 0.0151
Iraq-Baghdad 11858 4 0.0096 0.0304 0.8845 0.0187 0.0192 0.0205 0.0045 0.0126
Iraq-Baghdad 11859 9 0.0446 0.0971 0.7963 0.0086 0.0129 0.0235 0.0071 0.0099
Iraq-Baghdad 11862 3 0.0129 0.1648 0.5964 0.0929 0.053 0.0618 0.0031 0.0151
Iraq-Baghdad 11865 2 0.0211 0.0974 0.8228 0.0055 0.0122 0.0105 0.0189 0.0116
Iraq-Baghdad 11868 4 0.009 0.081 0.8525 0.0166 0.0127 0.0184 0.0048 0.0051
Iraq-Baghdad 11869 2 0.0199 0.2129 0.6427 0.0188 0.0295 0.0543 0.0075 0.0144
Iraq-Baghdad 11870 0 0.9272 0.0089 0.0112 0.0127 0.0128 0.0128 0.0025 0.0119
Iraq-Baghdad 11871 0 0.01 0.0489 0.8995 0.0107 0.005 0.0187 0.0039 0.0033
Iraq-Baghdad 11872 6 0.0302 0.3878 0.5101 0.0081 0.0112 0.0372 0.0066 0.0088
Iraq-Baghdad 11873 6 0.0059 0.124 0.7839 0.0056 0.0387 0.0225 0.0103 0.0091
Iraq-Baghdad 11874 11 0.0248 0.0922 0.7799 0.0168 0.0186 0.0324 0.0102 0.0251
Iraq-Baghdad 11875 18 0.0083 0.0441 0.8968 0.01 0.0079 0.0188 0.0037 0.0104
Iraq-Baghdad 11876 19 0.0152 0.4873 0.3901 0.0252 0.045 0.0205 0.01 0.0067
Iraq-Baghdad 11877 2 0.0156 0.3172 0.6022 0.0081 0.0261 0.0108 0.0093 0.0107
Iraq-Baghdad 11878 2 0.0182 0.0563 0.8797 0.0061 0.0202 0.0089 0.0032 0.0074
Iraq-Baghdad 11879 12 0.0828 0.2126 0.122 0.4716 0.0587 0.0331 0.0049 0.0143
Iraq-Baghdad 11880 2 0.0275 0.4851 0.0963 0.3449 0.0129 0.0176 0.0063 0.0094
Iraq-Baghdad 11881 13 0.0309 0.4225 0.073 0.435 0.0096 0.0137 0.0046 0.0107
Iraq-Baghdad 11882 23 0.0226 0.1957 0.0664 0.3916 0.1907 0.0843 0.0275 0.0212
Iraq-Baghdad 11883 8 0.0227 0.2335 0.0854 0.5987 0.0055 0.0132 0.0072 0.0339
Iraq-Baghdad 11884 2 0.0106 0.0849 0.0228 0.5902 0.119 0.1462 0.0144 0.0119
Iraq-Baghdad 11885 2 0.0346 0.2034 0.0962 0.6267 0.0175 0.0112 0.0049 0.0056
Iraq-Baghdad 11886 1 0.0367 0.3376 0.0432 0.5355 0.0084 0.0246 0.0076 0.0064
Iraq-Baghdad 11887 2 0.0189 0.1157 0.0338 0.5075 0.0081 0.0447 0.2487 0.0226
Iran 9419 3 0.0118 0.2221 0.0463 0.6745 0.0189 0.0167 0.0034 0.0063
Iran 9420 20 0.0173 0.3386 0.0368 0.5055 0.0381 0.0247 0.0152 0.0238
Iran 9421 18 0.0121 0.2742 0.0283 0.5848 0.0359 0.035 0.0163 0.0134
Iran 9422 0 0.0098 0.2846 0.0268 0.6544 0.0071 0.0061 0.0034 0.0078
Iran 9424 1 0.0183 0.0989 0.0361 0.6938 0.0204 0.1165 0.0089 0.0071
Iran 9425 0 0.0289 0.4359 0.0573 0.4261 0.027 0.0169 0.0021 0.0057
Iran 9426 1 0.0299 0.2645 0.0334 0.572 0.0308 0.0186 0.0344 0.0164
Iran 9427 18 0.0069 0.1064 0.0097 0.8224 0.0231 0.0126 0.0102 0.0086
Iran 9428 9 0.0065 0.4848 0.0573 0.3387 0.021 0.0312 0.0457 0.0147
Iran 9429 22 0.01 0.2284 0.0242 0.673 0.0131 0.0325 0.0093 0.0094
Iran 9430 1 0.0315 0.2226 0.0834 0.6039 0.0343 0.0135 0.0066 0.0042
Iran 9431 2 0.0462 0.3501 0.0301 0.5301 0.0149 0.0159 0.0038 0.0089
Iran 9432 0 0.0056 0.3826 0.049 0.4477 0.0148 0.0268 0.0476 0.0259
Iran 9433 3 0.0282 0.2226 0.0533 0.6615 0.0105 0.0076 0.0056 0.0106
Iran 9434 1 0.0122 0.5052 0.0315 0.4262 0.0089 0.0068 0.004 0.0052
Iran 9435 2 0.015 0.3905 0.0836 0.4113 0.0086 0.0234 0.0253 0.0424
Iran 9436 10 0.0093 0.1247 0.0347 0.6786 0.0129 0.0502 0.061 0.0286
Iran 9437 8 0.0226 0.2728 0.0449 0.6013 0.0141 0.029 0.0059 0.0095
Iran 9438 1 0.082 0.5305 0.1228 0.0737 0.1182 0.0565 0.0093 0.0069 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iran 9439 2 0.066 0.3368 0.0813 0.3698 0.05 0.0421 0.0042 0.0497
Iran 9440 4 0.0101 0.202 0.0088 0.7326 0.0247 0.011 0.0053 0.0055
Iran 9441 2 0.0153 0.4654 0.0932 0.3348 0.043 0.0231 0.0139 0.0114
Iran 9442 0 0.0157 0.3089 0.0769 0.5043 0.0103 0.014 0.0079 0.062
Iran 9443 1 0.0095 0.3381 0.0434 0.5637 0.0087 0.0238 0.0073 0.0055
Iran 9444 1 0.007 0.1664 0.0319 0.6336 0.0796 0.0469 0.0296 0.005
Iran 9445 2 0.0077 0.474 0.1321 0.3021 0.0109 0.0286 0.0294 0.0152
Iran 9446 2 0.0959 0.3054 0.0517 0.5078 0.0122 0.0154 0.0065 0.005
Iran 9447 0 0.0145 0.1241 0.0154 0.6357 0.0138 0.0262 0.1564 0.0139
Iran 9448 3 0.0419 0.3079 0.0755 0.4535 0.0086 0.0624 0.0104 0.0398
Iran 9449 2 0.0425 0.537 0.0263 0.3502 0.0149 0.0102 0.0034 0.0155
Iran 9450 0 0.0094 0.2644 0.0351 0.6021 0.008 0.0116 0.0544 0.015
Iran 9451 2 0.0455 0.3321 0.1815 0.3716 0.0184 0.0191 0.0075 0.0244
Iran 9452 17 0.0271 0.3026 0.0492 0.5503 0.0107 0.0259 0.0108 0.0234
Iran 9453 0 0.0038 0.3402 0.1015 0.2946 0.0099 0.0701 0.1736 0.0064
Iran 9454 2 0.0112 0.2873 0.038 0.4008 0.0475 0.1819 0.014 0.0193
Iran 9455 16 0.0133 0.1809 0.0621 0.4158 0.0566 0.2518 0.0135 0.006
Iran 9456 22 0.0085 0.1605 0.0176 0.6798 0.0626 0.0489 0.0133 0.0089
Iran 9457 17 0.0212 0.2918 0.0719 0.3444 0.0938 0.116 0.0175 0.0434
Iran 9458 20 0.0081 0.1583 0.048 0.5994 0.1141 0.029 0.0042 0.0389
Iran 9459 18 0.0073 0.1305 0.0341 0.6046 0.1608 0.0264 0.0041 0.0322
Iran 9460 25 0.0046 0.0706 0.0094 0.4993 0.2799 0.1181 0.0077 0.0104
Iran 9461 4 0.0059 0.1872 0.0737 0.6339 0.024 0.0375 0.0151 0.0227
Iran 9462 6 0.0132 0.0195 0.0181 0.7147 0.0383 0.0161 0.0127 0.1674
Iran 9463 3 0.0069 0.0243 0.0162 0.7772 0.0141 0.0512 0.0941 0.0159
Iran 9464 2 0.0079 0.2171 0.0972 0.1407 0.4055 0.0609 0.031 0.0396
Iran 9465 0 0.0121 0.1648 0.0351 0.485 0.0664 0.1019 0.0756 0.0591
Iran 9466 10 0.0164 0.2698 0.157 0.273 0.1512 0.1163 0.0046 0.0117
Iran 9468 0 0.0059 0.1664 0.0221 0.6426 0.1134 0.0238 0.014 0.0118
Iran 9469 1 0.0058 0.0784 0.0186 0.7109 0.007 0.0373 0.1248 0.0172
Iran 9470 1 0.0397 0.1706 0.0461 0.5045 0.023 0.1513 0.0076 0.0572
Iran 9471 0 0.0102 0.2077 0.0195 0.7203 0.0103 0.0221 0.0048 0.0051
Iran 9472 2 0.0058 0.0849 0.0109 0.8451 0.0097 0.0164 0.0122 0.015
Iran 9473 18 0.0068 0.14 0.0127 0.7593 0.0315 0.0286 0.007 0.0141
Iran 9474 1 0.0056 0.0115 0.0107 0.8495 0.0875 0.0189 0.0059 0.0104
Iran 9475 1 0.0038 0.0082 0.0086 0.9267 0.006 0.0065 0.0138 0.0264
Iran 9476 0 0.0037 0.0054 0.0047 0.948 0.0216 0.0058 0.0032 0.0076
Iran 9477 1 0.006 0.0109 0.0061 0.9563 0.0061 0.0073 0.0028 0.0045
Iran 9478 1 0.004 0.0072 0.0043 0.9626 0.0063 0.006 0.0024 0.0072
Iran 9479 2 0.0033 0.019 0.0111 0.9292 0.0109 0.0066 0.0074 0.0125
Iran 9480 0 0.0069 0.0158 0.0086 0.9184 0.0103 0.0195 0.0129 0.0076
Iran 9481 0 0.0044 0.0135 0.0077 0.9079 0.0079 0.012 0.0341 0.0125
Iran 9482 1 0.0043 0.0101 0.0074 0.9378 0.0085 0.0056 0.0067 0.0196
Iran 9483 2 0.0055 0.007 0.0069 0.9349 0.0168 0.0066 0.0136 0.0087
Iran 9484 22 0.007 0.0352 0.0097 0.8954 0.0236 0.0134 0.0052 0.0105
Iran 9485 0 0.0051 0.0096 0.0118 0.9042 0.0398 0.0092 0.004 0.0163
Iran 9486 0 0.0038 0.0059 0.0082 0.8812 0.0084 0.0106 0.0097 0.0722
Iran 9487 0 0.0056 0.0093 0.0075 0.9456 0.0078 0.0127 0.0041 0.0074
Iran 9488 2 0.0031 0.0053 0.004 0.9468 0.0098 0.0135 0.0087 0.0088
Iran 9489 0 0.0063 0.0065 0.0049 0.9617 0.005 0.0051 0.0049 0.0056
Iran 9490 2 0.003 0.0087 0.0062 0.9607 0.0051 0.0056 0.0066 0.0041
Iran 9491 0 0.0028 0.0048 0.0031 0.9666 0.0062 0.0049 0.0057 0.0059
Iran 9492 1 0.0137 0.0342 0.0268 0.8536 0.0123 0.0378 0.0146 0.007
Iran 9493 4 0.0027 0.0048 0.0041 0.9608 0.0092 0.0073 0.0061 0.005
Iran 9494 2 0.0048 0.007 0.0061 0.944 0.013 0.0082 0.0118 0.0051
Iran 9495 0 0.0021 0.0036 0.0031 0.9698 0.007 0.0045 0.003 0.0069 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iran 9497 2 0.0058 0.0265 0.0102 0.9101 0.0211 0.0127 0.0073 0.0063
Iran 9498 0 0.0058 0.0115 0.0152 0.8991 0.0074 0.0151 0.0125 0.0334
Iran 9499 1 0.0197 0.0259 0.0198 0.8715 0.0261 0.024 0.0048 0.0082
Iran 9500 0 0.0061 0.0063 0.0055 0.9417 0.0149 0.0108 0.0039 0.0108
Iran 9501 0 0.0035 0.0077 0.0051 0.94 0.0138 0.0095 0.007 0.0134
Iran 9502 0 0.0061 0.007 0.0071 0.9027 0.0069 0.0279 0.0154 0.0269
Iran 9503 1 0.0055 0.011 0.0103 0.9454 0.0105 0.0072 0.0048 0.0053
Iran 9504 0 0.0033 0.005 0.0043 0.905 0.0524 0.0089 0.0062 0.0149
Iran 9505 1 0.0041 0.0066 0.0042 0.926 0.0092 0.02 0.0111 0.0187
Iran 9506 0 0.0093 0.0318 0.0091 0.8752 0.0058 0.0117 0.0045 0.0527
Iran 9507 1 0.0041 0.0173 0.0071 0.9004 0.0108 0.0147 0.0069 0.0387
Iran 9508 0 0.0182 0.1299 0.0174 0.7366 0.0197 0.0467 0.0059 0.0256
Iran 9509 0 0.0041 0.0124 0.0084 0.8008 0.0204 0.0493 0.0524 0.0522
Iran 9510 0 0.0095 0.0162 0.0065 0.8724 0.0642 0.0183 0.0045 0.0084
Iran 9511 0 0.0251 0.0262 0.0174 0.8654 0.0076 0.015 0.0139 0.0294
Iran 9512 0 0.0074 0.0227 0.0094 0.862 0.0339 0.0316 0.0062 0.0267
Iran 9513 2 0.0196 0.0121 0.0201 0.8927 0.0239 0.018 0.0073 0.0063
Iran 9514 1 0.0101 0.0183 0.014 0.8726 0.024 0.0258 0.0306 0.0046
Iran 9515 0 0.01 0.016 0.021 0.8647 0.0391 0.0183 0.0069 0.024
Iran 9516 1 0.0082 0.0147 0.0107 0.946 0.0077 0.0047 0.0049 0.0031
Iran 9517 1 0.0039 0.0446 0.0078 0.8479 0.0578 0.0214 0.011 0.0056
Iran 9518 1 0.0101 0.0059 0.0039 0.8436 0.0062 0.0149 0.0374 0.078
Iran 9519 1 0.0057 0.0058 0.0041 0.8319 0.1185 0.0174 0.0057 0.0109
Iran 9520 2 0.0143 0.2207 0.0603 0.5458 0.0131 0.0214 0.0057 0.1186
Iran 9521 2 0.0159 0.0991 0.0646 0.7526 0.0178 0.0398 0.0041 0.0061
Iran 9522 0 0.0066 0.0185 0.0081 0.8807 0.0171 0.0163 0.0047 0.048
Iran 9523 1 0.0046 0.0062 0.0051 0.8773 0.085 0.0116 0.0036 0.0066
Iran 9524 1 0.0102 0.0173 0.0179 0.899 0.0108 0.0253 0.0057 0.0138
Iran 9526 1 0.0105 0.0321 0.0265 0.784 0.007 0.0246 0.1105 0.0048
Iran 9527 0 0.0208 0.0141 0.0281 0.894 0.0083 0.014 0.0069 0.0138
Iran 9528 0 0.0121 0.0072 0.0069 0.9274 0.0182 0.0071 0.0028 0.0183
Iran 9529 0 0.0039 0.0099 0.0064 0.9197 0.0118 0.0199 0.0188 0.0096
Iran 9530 2 0.0089 0.0229 0.0142 0.9044 0.0167 0.0134 0.0144 0.0051
Iran 9531 1 0.0072 0.0079 0.0072 0.938 0.009 0.008 0.0074 0.0153
Iran 9532 1 0.0032 0.0052 0.0046 0.9605 0.0068 0.006 0.005 0.0087
Dubai 10104 0 0.006 0.0063 0.0064 0.9482 0.0142 0.0072 0.0057 0.006
Dubai 10105 1 0.0043 0.0069 0.006 0.9264 0.0161 0.008 0.0063 0.026
Dubai 10106 0 0.004 0.0054 0.0049 0.9584 0.0066 0.0057 0.0053 0.0097
Dubai 10107 2 0.0062 0.0075 0.0083 0.9342 0.016 0.0061 0.0032 0.0185
Dubai 10108 0 0.0046 0.011 0.0054 0.9408 0.0177 0.0077 0.0057 0.0071
Dubai 10109 1 0.0113 0.0345 0.0079 0.9148 0.0113 0.0097 0.0062 0.0043
Dubai 10110 4 0.0052 0.0131 0.0087 0.9452 0.0066 0.0115 0.0066 0.0031
Dubai 10111 2 0.0726 0.0257 0.0311 0.7494 0.0628 0.0435 0.0059 0.0089
Dubai 10112 1 0.0043 0.0079 0.0053 0.959 0.0094 0.0068 0.0032 0.0041
Dubai 10120 2 0.016 0.0147 0.0155 0.9253 0.0098 0.0096 0.0052 0.0039
Kenya-Nairobi 9833 6 0.0363 0.0507 0.0138 0.7907 0.0288 0.0335 0.0288 0.0174
Kenya-Nairobi 9834 0 0.0397 0.0263 0.0246 0.7146 0.0821 0.0918 0.0053 0.0155
Kenya-Nairobi 9835 2 0.0043 0.0137 0.0046 0.9266 0.0341 0.0078 0.0039 0.005
Kenya-Nairobi 9836 2 0.0079 0.0173 0.0068 0.8738 0.0434 0.0155 0.0053 0.03
Kenya-Nairobi 9837 2 0.004 0.006 0.0052 0.9521 0.008 0.0074 0.0066 0.0107
Kenya-Nairobi 9838 0 0.0052 0.011 0.011 0.8914 0.0118 0.0332 0.0137 0.0227
Kenya-Nairobi 9839 1 0.003 0.0058 0.005 0.9573 0.0102 0.0049 0.0037 0.0101
Kenya-Nairobi 9840 2 0.0064 0.0133 0.0119 0.8319 0.0985 0.0209 0.0061 0.011
Kenya-Nairobi 9841 2 0.0116 0.0353 0.0295 0.8798 0.0083 0.0124 0.0111 0.012
Kenya-Nairobi 9842 2 0.0024 0.0066 0.0033 0.9578 0.0084 0.008 0.0067 0.0068
Kenya-Nairobi 9843 5 0.0042 0.0105 0.0078 0.9335 0.0169 0.008 0.006 0.0131 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Kenya-Nairobi 9844 0 0.0055 0.0074 0.0049 0.9529 0.0074 0.0071 0.0047 0.0101
Kenya-Nairobi 9845 1 0.0031 0.0194 0.0044 0.9285 0.0109 0.0163 0.0122 0.0052
Kenya-Nairobi 9846 0 0.0047 0.0131 0.0085 0.9261 0.0112 0.015 0.0054 0.016
Kenya-Nairobi 9847 1 0.003 0.0073 0.0045 0.9465 0.0233 0.0072 0.0039 0.0043
Kenya-Nairobi 9848 4 0.0053 0.0071 0.0049 0.8729 0.0509 0.0216 0.0053 0.032
Kenya-Nairobi 9849 7 0.003 0.0134 0.0056 0.9533 0.0066 0.0102 0.0033 0.0046
Kenya-Nairobi 9850 0 0.0162 0.0123 0.01 0.9057 0.0265 0.0168 0.0055 0.0069
Kenya-Nairobi 9851 0 0.0029 0.0044 0.0049 0.9612 0.0069 0.0053 0.004 0.0104
Kenya-Nairobi 9852 2 0.002 0.0035 0.0031 0.9699 0.0072 0.0044 0.003 0.0069
Kenya-Nairobi 9853 1 0.0046 0.0126 0.009 0.9132 0.0077 0.0213 0.0196 0.012
Kenya-Nairobi 9854 3 0.0054 0.0093 0.0073 0.8978 0.0259 0.0081 0.008 0.0382
Kenya-Nairobi 9855 1 0.0053 0.0114 0.0074 0.9514 0.0044 0.0091 0.0066 0.0044
Kenya-Nairobi 9856 4 0.0038 0.0079 0.0083 0.9519 0.0094 0.0094 0.003 0.0063
Kenya-Nairobi 9857 2 0.005 0.0137 0.0107 0.9051 0.0079 0.0235 0.0202 0.0139
Kenya-Nairobi 9858 16 0.0856 0.2827 0.1344 0.2372 0.045 0.0749 0.1346 0.0057
Kenya-Nairobi 9859 0 0.0443 0.0577 0.0392 0.0221 0.7812 0.0465 0.0033 0.0056
Kenya-Nairobi 9860 2 0.0223 0.065 0.0999 0.2842 0.4256 0.0516 0.0438 0.0076
Kenya-Nairobi 9861 0 0.0059 0.0143 0.0108 0.0936 0.414 0.4349 0.0157 0.0109
Kenya-Nairobi 9862 0 0.0221 0.0878 0.0293 0.4245 0.2995 0.0601 0.015 0.0617
Kenya-Nairobi 9863 2 0.018 0.1869 0.0748 0.0481 0.572 0.05 0.0301 0.0201
Kenya-Nairobi 9864 1 0.0098 0.0196 0.015 0.0986 0.3897 0.2668 0.0234 0.1771
Kenya-Nairobi 9865 2 0.0151 0.0434 0.0495 0.0477 0.7614 0.0467 0.0295 0.0068
Kenya-Nairobi 9866 2 0.0123 0.032 0.0193 0.3694 0.4188 0.1399 0.0035 0.0048
Kenya-Nairobi 9867 0 0.0072 0.1017 0.0197 0.2399 0.5035 0.0807 0.0314 0.0159
Kenya-Nairobi 9868 0 0.0093 0.0227 0.0255 0.1019 0.7605 0.0376 0.0059 0.0366
Kenya-Pate 2000 0 0.0052 0.0117 0.009 0.0424 0.8919 0.0098 0.0058 0.0242
Kenya-Pate 2001 0 0.0043 0.004 0.0031 0.0101 0.9608 0.0053 0.0061 0.0063
Kenya-Pate 2002 0 0.0049 0.0045 0.0034 0.012 0.9574 0.0052 0.0058 0.0068
Kenya-Pate 2003 0 0.0048 0.0055 0.0046 0.0064 0.9661 0.0057 0.0022 0.0047
Kenya-Pate 2004 1 0.0048 0.0155 0.0154 0.0097 0.9015 0.0212 0.0234 0.0085
Kenya-Pate 2006 2 0.0161 0.0081 0.0064 0.0094 0.933 0.0054 0.0034 0.0182
Kenya-Pate 2007 3 0.009 0.0132 0.0127 0.008 0.9199 0.0113 0.0031 0.0228
Kenya-Pate 2009 0 0.0115 0.0371 0.0233 0.0391 0.8493 0.0197 0.0096 0.0103
Kenya-Pate 2011 0 0.0068 0.013 0.0124 0.0193 0.8722 0.0444 0.0103 0.0216
Kenya-Lamu 1848 14 0.0132 0.0251 0.0246 0.0071 0.8378 0.0481 0.007 0.0371
Kenya-Lamu 2014 4 0.0284 0.0363 0.0118 0.2268 0.6639 0.0102 0.0049 0.0177
Kenya-Lamu 2015 0 0.0078 0.0051 0.004 0.0044 0.92 0.0186 0.0303 0.0098
Kenya-Lamu 2016 0 0.0038 0.0098 0.0077 0.0241 0.8601 0.024 0.0562 0.0143
Kenya-Lamu 2018 0 0.0457 0.0063 0.0046 0.0064 0.9204 0.0063 0.0052 0.0051
Kenya-Lamu 2019 0 0.0312 0.058 0.0697 0.0084 0.7664 0.05 0.0081 0.0083
Kenya-Lamu 2021 1 0.0608 0.0443 0.0317 0.0414 0.7045 0.0266 0.0148 0.0759
Kenya-Lamu 2023 1 0.0036 0.0043 0.0048 0.0074 0.9602 0.0059 0.0063 0.0075
Kenya-Lamu 2024 2 0.0042 0.0076 0.0055 0.0098 0.9542 0.0078 0.005 0.0059
Kenya-Lamu 2025 3 0.0085 0.0059 0.0051 0.0072 0.9553 0.0055 0.003 0.0095
Kenya-Lamu 2026 1 0.0107 0.0203 0.0361 0.0128 0.8933 0.0115 0.005 0.0103
Kenya-Lamu 2027 2 0.0073 0.0069 0.0056 0.0089 0.8997 0.0111 0.0056 0.0549
Kenya-Lamu 2029 1 0.0041 0.0066 0.0055 0.0081 0.9574 0.0078 0.0051 0.0054
Kenya-Lamu 2030 0 0.0075 0.0091 0.0084 0.0295 0.924 0.0103 0.0031 0.0081
Kenya-Lamu 2031 0 0.0079 0.0112 0.0109 0.068 0.845 0.0258 0.0064 0.0248
Kenya-Lamu 2032 0 0.0067 0.0152 0.0182 0.0572 0.8627 0.0123 0.0067 0.0211
Kenya-Lamu 2033 0 0.0031 0.0057 0.0052 0.0077 0.9657 0.0063 0.0031 0.0032
Kenya-Lamu 3241 0 0.0157 0.0341 0.0258 0.0169 0.8764 0.0174 0.0059 0.0078
Kenya-Lamu 3246 0 0.0153 0.0057 0.0054 0.0051 0.8894 0.0239 0.0425 0.0127
Kenya-Lamu 3247 0 0.0115 0.0075 0.0128 0.0071 0.9151 0.0131 0.0103 0.0226
India-Udaipur 11835 7 0.0061 0.0114 0.0059 0.1045 0.0078 0.7642 0.0528 0.0473
India-Udaipur 11836 3 0.042 0.0331 0.0254 0.145 0.0099 0.6785 0.01 0.056 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Missing Population
Data 1 2 3 4 5 6 7 8
India-Udaipur 11837 1 0.004 0.0141 0.0095 0.051 0.261 0.541 0.0213 0.0981
India-Agra 11823 2 0.0092 0.0847 0.0329 0.0969 0.0133 0.5361 0.066 0.1609
India-Agra 11824 2 0.0125 0.0799 0.165 0.2201 0.2554 0.2475 0.0063 0.0133
India-Agra 11825 2 0.005 0.0962 0.0116 0.3637 0.0219 0.2722 0.0092 0.2202
India-Agra 11826 6 0.0057 0.0421 0.0194 0.1086 0.0279 0.3254 0.0062 0.4647
India-Agra 11827 25 0.0189 0.1981 0.0543 0.3265 0.0422 0.2944 0.0284 0.0371
India-Agra 11828 2 0.0145 0.458 0.1678 0.0208 0.1538 0.1515 0.0116 0.022
India-Agra 11829 4 0.0081 0.0272 0.0146 0.4481 0.0288 0.3092 0.0176 0.1465
India-Agra 11830 8 0.0147 0.1537 0.034 0.3953 0.025 0.3117 0.0069 0.0586
India-Agra 11831 2 0.0064 0.1822 0.0122 0.5332 0.024 0.1034 0.0118 0.1268
India-Agra 11832 2 0.0063 0.0759 0.0089 0.3934 0.0181 0.416 0.0196 0.0617
India-Agra 11833 20 0.0075 0.0314 0.0226 0.019 0.2423 0.5895 0.0604 0.0273
India-Agra 11834 2 0.0069 0.0522 0.0185 0.1321 0.0223 0.2839 0.0065 0.4776
India-Hyderbad 11802 14 0.0042 0.0218 0.0173 0.012 0.0117 0.8432 0.0773 0.0125
India-Hyderbad 11803 7 0.0034 0.0178 0.0084 0.0692 0.0576 0.8204 0.0126 0.0106
India-Hyderbad 11804 4 0.0032 0.0077 0.006 0.0273 0.037 0.8421 0.0376 0.0391
India-Hyderbad 11805 11 0.0047 0.014 0.0223 0.0195 0.0653 0.8498 0.0174 0.007
India-Hyderbad 11807 13 0.033 0.0199 0.0322 0.0125 0.0627 0.7689 0.0353 0.0356
India-Hyderbad 11808 10 0.0344 0.0211 0.0303 0.0106 0.1872 0.6834 0.0105 0.0224
India-Hyderbad 11809 4 0.0459 0.0738 0.0135 0.0425 0.0543 0.7282 0.0195 0.0224
India-Hyderbad 11810 0 0.0079 0.0155 0.0185 0.0845 0.2349 0.4859 0.0097 0.1431
India-Hyderbad 11811 0 0.0567 0.0178 0.0748 0.0102 0.0569 0.7598 0.0056 0.0182
India-Hyderbad 11812 0 0.0038 0.0081 0.0104 0.0168 0.0676 0.8639 0.0144 0.015
India-Hyderbad 11813 2 0.0076 0.014 0.0161 0.0071 0.029 0.8419 0.0732 0.0112
India-Hyderbad 11814 2 0.0047 0.0216 0.0166 0.0558 0.0214 0.8582 0.0173 0.0044
India-Hyderbad 11815 2 0.007 0.0477 0.0329 0.0081 0.0133 0.8657 0.0187 0.0066
India-Hyderbad 11816 4 0.0065 0.0184 0.0085 0.1971 0.0851 0.6486 0.0055 0.0303
India-Hyderbad 11817 2 0.0034 0.0134 0.0134 0.014 0.0219 0.8772 0.0483 0.0084
India-Hyderbad 11818 1 0.4405 0.0183 0.0304 0.0141 0.1267 0.1626 0.2022 0.0052
India-Hyderbad 11819 6 0.0084 0.0344 0.013 0.1712 0.113 0.6199 0.0056 0.0345
India-Hyderbad 11820 6 0.0031 0.0106 0.0103 0.0557 0.0429 0.8148 0.044 0.0185
India-Hyderbad 11821 17 0.0083 0.0393 0.0389 0.0207 0.0645 0.6513 0.164 0.0131
India-Hyderbad 11822 2 0.0053 0.0107 0.0154 0.0874 0.0654 0.781 0.0207 0.0141
India-Andhra 10159 1 0.0178 0.0229 0.0272 0.1705 0.0107 0.678 0.0476 0.0253
India-Andhra 10160 1 0.0053 0.0081 0.0078 0.0122 0.0113 0.6141 0.2167 0.1245
India-Andhra 10161 2 0.017 0.0228 0.0131 0.0369 0.081 0.7808 0.0375 0.0109
India-Andhra 10162 5 0.011 0.0102 0.0109 0.0441 0.0105 0.7626 0.14 0.0107
India-Andhra 10163 0 0.0082 0.0122 0.0107 0.0217 0.0695 0.8088 0.0566 0.0123
India-Andhra 10164 2 0.0944 0.0255 0.0181 0.0228 0.01 0.7638 0.0512 0.0143
India-Andhra 10165 1 0.0257 0.0258 0.0469 0.0194 0.0456 0.3363 0.491 0.0092
India-Andhra 10166 2 0.0093 0.0764 0.0299 0.089 0.0732 0.4868 0.2196 0.0158
India-Andhra 10167 0 0.0064 0.0069 0.0082 0.0168 0.0345 0.5586 0.3478 0.0208
India-Andhra 10168 1 0.0344 0.0209 0.0539 0.0102 0.0223 0.6305 0.2121 0.0157
India-Andhra 10169 7 0.0054 0.0086 0.0069 0.0091 0.0682 0.8535 0.0407 0.0076
India-Andhra 10170 6 0.007 0.0348 0.0499 0.0104 0.0949 0.6735 0.1065 0.0231
India-Andhra 10171 1 0.0923 0.0251 0.017 0.0237 0.01 0.7657 0.0524 0.0139
India-Andhra 10172 2 0.0062 0.0085 0.0097 0.0117 0.0988 0.7613 0.0956 0.0082
India-Andhra 10173 2 0.0118 0.0172 0.0179 0.0146 0.0337 0.7665 0.1328 0.0054
India-Andhra 10174 3 0.0069 0.008 0.0119 0.0069 0.048 0.7983 0.0757 0.0443
India-Andhra 10175 2 0.0237 0.0391 0.0716 0.0133 0.0384 0.6239 0.0584 0.1315
India-Andhra 10176 2 0.009 0.0312 0.0162 0.0138 0.0198 0.8628 0.0219 0.0253
India-Andhra 10177 0 0.197 0.0094 0.0075 0.0358 0.0224 0.5453 0.1257 0.0569
India-Andhra 10178 2 0.0072 0.0068 0.0073 0.0083 0.0467 0.7306 0.1842 0.0089
India-Andhra 10179 5 0.0069 0.0074 0.0051 0.0096 0.4515 0.3078 0.2017 0.01
India-Andhra 10180 12 0.0208 0.0108 0.0204 0.0853 0.017 0.7135 0.0499 0.0823
India-Andhra 10181 4 0.0082 0.0122 0.0088 0.0236 0.0517 0.7971 0.0831 0.0153 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
India-Kolkata 10113 0 0.0052 0.0125 0.0102 0.029 0.1619 0.6324 0.0043 0.1446
India-Kolkata 10114 1 0.0061 0.0247 0.0096 0.0138 0.0528 0.6832 0.1886 0.0212
India-Kolkata 10115 1 0.0086 0.0669 0.0544 0.0112 0.0392 0.7438 0.036 0.0399
India-Kolkata 10116 1 0.0029 0.0415 0.0078 0.0999 0.0282 0.5887 0.2034 0.0275
India-Kolkata 10117 2 0.0071 0.065 0.0279 0.0109 0.0467 0.752 0.0788 0.0117
India-Kolkata 10118 0 0.0614 0.1603 0.0992 0.0215 0.0198 0.4194 0.1579 0.0606
India-Kolkata 10119 2 0.0806 0.1532 0.093 0.0886 0.0581 0.4495 0.0433 0.0338
Sri Lanka 8780 2 0.0483 0.0296 0.0217 0.0139 0.2366 0.4524 0.0142 0.1833
Sri Lanka 8781 0 0.0532 0.041 0.0196 0.0108 0.1335 0.5079 0.0895 0.1444
Sri Lanka 8782 0 0.0157 0.0255 0.0527 0.0088 0.1014 0.7458 0.0217 0.0284
Sri Lanka 8783 0 0.0374 0.1252 0.3072 0.01 0.0178 0.4467 0.0479 0.0078
Sri Lanka 8784 0 0.325 0.0999 0.0303 0.0077 0.0251 0.3352 0.145 0.0318
Sri Lanka 8785 11 0.1125 0.0236 0.0124 0.0241 0.0657 0.6425 0.07 0.0493
Sri Lanka 8786 0 0.023 0.0245 0.0169 0.0199 0.1936 0.534 0.0352 0.1528
Sri Lanka 8787 0 0.0798 0.0175 0.0111 0.0058 0.0817 0.7888 0.0069 0.0084
Sri Lanka 8788 4 0.028 0.0329 0.1215 0.0099 0.1415 0.6453 0.0127 0.0082
Sri Lanka 8789 2 0.0987 0.0681 0.3622 0.0137 0.0776 0.0823 0.2557 0.0415
Sri Lanka 8790 1 0.1667 0.0812 0.0367 0.0161 0.0178 0.293 0.3834 0.0051
Sri Lanka 8791 0 0.0654 0.2282 0.1887 0.0127 0.0226 0.3205 0.1378 0.0241
Sri Lanka 8792 0 0.0088 0.0218 0.0532 0.0387 0.0712 0.7818 0.0059 0.0185
Sri Lanka 8793 1 0.0555 0.0196 0.0741 0.0453 0.1449 0.6362 0.0115 0.0128
Sri Lanka 8794 1 0.0398 0.0214 0.0567 0.108 0.0686 0.6686 0.0094 0.0276
Sri Lanka 8795 1 0.2526 0.037 0.0715 0.015 0.2086 0.3528 0.0308 0.0317
Sri Lanka 8796 3 0.0161 0.0396 0.0499 0.0333 0.0951 0.5129 0.0376 0.2155
Sri Lanka 8797 0 0.1746 0.0544 0.033 0.0399 0.0406 0.4824 0.1572 0.0179
Sri Lanka 8798 0 0.0309 0.143 0.1005 0.0175 0.0219 0.5893 0.0142 0.0827
Sri Lanka 8799 1 0.1612 0.0172 0.0354 0.0121 0.0628 0.6906 0.0111 0.0096
Sri Lanka 8800 0 0.3314 0.044 0.0257 0.0131 0.0691 0.4522 0.0502 0.0143
Sri Lanka 8801 4 0.0764 0.0262 0.0279 0.0087 0.0666 0.7749 0.008 0.0113
Sri Lanka 8802 2 0.1278 0.0192 0.0323 0.0063 0.1581 0.618 0.0112 0.0271
Sri Lanka 8803 4 0.0681 0.0233 0.0951 0.0138 0.0774 0.2957 0.2675 0.1592
Thailand 11688 6 0.0257 0.0075 0.0062 0.0031 0.0135 0.0056 0.9335 0.0049
Thailand 11689 13 0.0048 0.0061 0.0044 0.0048 0.0034 0.0059 0.9535 0.0171
Thailand 11691 20 0.0251 0.0114 0.015 0.0095 0.0087 0.0359 0.8786 0.0158
Thailand 11698 17 0.0053 0.0053 0.0049 0.003 0.0021 0.0074 0.9678 0.0042
Thailand 11702 10 0.0028 0.0021 0.0028 0.0039 0.0036 0.004 0.9671 0.0137
Thailand 11703 12 0.0043 0.0051 0.0068 0.0038 0.0051 0.0089 0.9549 0.0111
Thailand 11705 21 0.0079 0.0217 0.0207 0.0319 0.0452 0.0343 0.825 0.0133
Thailand 11707 3 0.0027 0.0041 0.0038 0.0058 0.0045 0.0084 0.9625 0.0082
Thailand 11708 22 0.0041 0.0043 0.0043 0.0048 0.0069 0.0076 0.958 0.01
Thailand 11709 12 0.0042 0.0067 0.0054 0.0113 0.007 0.0126 0.9452 0.0076
Thailand 11710 8 0.0103 0.0109 0.0105 0.0108 0.0054 0.0085 0.9252 0.0184
Thailand 11711 7 0.007 0.005 0.0062 0.0071 0.007 0.0056 0.9535 0.0086
Thailand 11714 5 0.008 0.0072 0.0071 0.0102 0.0046 0.0073 0.9496 0.006
Thailand 11715 16 0.0084 0.0247 0.0085 0.1675 0.0371 0.0166 0.7256 0.0116
Thailand 11717 15 0.0029 0.0047 0.0046 0.0135 0.0117 0.0113 0.944 0.0073
Thailand 11718 0 0.002 0.0027 0.0026 0.0045 0.0031 0.0047 0.9753 0.0051
Thailand 11720 3 0.0021 0.0022 0.002 0.0027 0.0033 0.0035 0.9812 0.003
Vietnam 8844 4 0.0242 0.0111 0.0055 0.0109 0.0094 0.0157 0.9109 0.0123
Vietnam 8845 1 0.0198 0.0318 0.0363 0.1173 0.0139 0.0218 0.7387 0.0205
Vietnam 8846 0 0.011 0.0185 0.0225 0.0079 0.007 0.1624 0.7642 0.0065
Vietnam 8847 9 0.0054 0.0045 0.0043 0.0031 0.0042 0.0056 0.9658 0.0071
Vietnam 8848 6 0.0056 0.0154 0.011 0.0091 0.0184 0.0285 0.8964 0.0156
Vietnam 8849 2 0.02 0.0343 0.0484 0.0152 0.0065 0.0387 0.8094 0.0275
Vietnam 8850 0 0.049 0.0845 0.0215 0.0315 0.0215 0.0365 0.7385 0.0171
Vietnam 8851 0 0.0213 0.0755 0.0617 0.0779 0.0063 0.0309 0.7192 0.0073 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Vietnam 8852 13 0.0309 0.0609 0.0264 0.0089 0.0479 0.0573 0.7288 0.0388
Vietnam 8853 1 0.0866 0.0949 0.0549 0.0089 0.0181 0.1195 0.5948 0.0222
Vietnam 8854 5 0.0106 0.032 0.0214 0.0422 0.0305 0.0814 0.7395 0.0424
Vietnam 8855 0 0.2697 0.0221 0.0583 0.0046 0.006 0.011 0.6205 0.0078
Vietnam 8856 0 0.019 0.02 0.0443 0.0305 0.0078 0.0911 0.7695 0.0178
Vietnam 8857 2 0.0242 0.0345 0.1661 0.0048 0.0235 0.2018 0.5294 0.0157
Vietnam 8858 0 0.0484 0.0271 0.2905 0.0087 0.0084 0.0247 0.5874 0.0048
Vietnam 8859 6 0.0192 0.0786 0.0386 0.0108 0.1204 0.0308 0.6787 0.023
Vietnam 8860 0 0.0082 0.0541 0.0207 0.0565 0.052 0.0793 0.633 0.0961
Vietnam 8861 0 0.0109 0.0996 0.0894 0.0327 0.0294 0.04 0.6182 0.08
Vietnam 8862 0 0.0316 0.2645 0.0297 0.1359 0.0257 0.0767 0.4134 0.0226
Vietnam 8863 0 0.1561 0.0374 0.1777 0.0192 0.0061 0.0226 0.5736 0.0073
Taiwan 8681 3 0.5988 0.01 0.0074 0.0077 0.0137 0.0123 0.0294 0.3207
Taiwan 8682 0 0.1407 0.0589 0.0403 0.0813 0.0511 0.1265 0.3831 0.1182
Taiwan 8683 2 0.0227 0.2842 0.1142 0.0669 0.0188 0.2839 0.031 0.1783
Taiwan 8684 2 0.5912 0.0131 0.0096 0.0279 0.0045 0.0134 0.028 0.3123
Taiwan 8685 2 0.0113 0.0172 0.01 0.0116 0.099 0.049 0.2604 0.5414
Taiwan 8686 6 0.069 0.0477 0.0286 0.0421 0.1558 0.122 0.0335 0.5014
Taiwan 8687 6 0.0088 0.0926 0.0465 0.0204 0.0105 0.0898 0.4907 0.2408
Taiwan 8688 21 0.0626 0.0533 0.0285 0.0877 0.0447 0.1327 0.2007 0.3898
Taiwan 8689 5 0.0135 0.0156 0.0206 0.3609 0.0099 0.0198 0.0249 0.5348
Taiwan 8690 0 0.0077 0.0124 0.0098 0.0463 0.011 0.0484 0.1458 0.7187
Taiwan 8691 14 0.0466 0.0359 0.0193 0.0622 0.0321 0.0544 0.1959 0.5536
Taiwan 8692 3 0.0917 0.0914 0.0458 0.0772 0.0417 0.0507 0.4872 0.1143
Taiwan 8693 0 0.0435 0.0138 0.0129 0.0251 0.0746 0.5199 0.0429 0.2673
Taiwan 8694 0 0.1651 0.2053 0.0361 0.0669 0.061 0.0144 0.1864 0.2647
Taiwan 8695 0 0.0535 0.0809 0.0499 0.0088 0.0067 0.0792 0.2074 0.5136
Taiwan 8696 8 0.9708 0.0054 0.0067 0.003 0.0048 0.0035 0.0021 0.0037
Taiwan 8697 0 0.7175 0.0103 0.0097 0.016 0.0197 0.0769 0.0123 0.1375
Taiwan 8698 4 0.9531 0.007 0.0075 0.0066 0.0069 0.0061 0.0038 0.009
Taiwan 8699 6 0.0158 0.0156 0.0465 0.052 0.1473 0.4495 0.0796 0.1938
Taiwan 8700 1 0.3523 0.0295 0.0328 0.0258 0.0187 0.0195 0.2145 0.3069
Taiwan 8701 2 0.0741 0.0103 0.0087 0.0117 0.0542 0.0285 0.1495 0.663
Taiwan 8702 1 0.296 0.0349 0.0211 0.01 0.0348 0.0598 0.0466 0.4967
Taiwan 8703 1 0.7562 0.0119 0.0362 0.0128 0.0408 0.0954 0.0288 0.0179
Taiwan 8704 0 0.0066 0.0228 0.1598 0.0054 0.0339 0.0218 0.1195 0.6302
Taiwan 8705 1 0.0115 0.0213 0.0286 0.0238 0.0267 0.0476 0.1907 0.6498
Taiwan 8706 0 0.07 0.0952 0.1384 0.2491 0.0243 0.1176 0.0711 0.2342
Taiwan 8707 4 0.0125 0.0975 0.0375 0.1074 0.0341 0.1234 0.0811 0.5065
Taiwan 8708 0 0.9342 0.0096 0.0068 0.008 0.0091 0.0137 0.0125 0.0061
Taiwan 8709 2 0.0098 0.0188 0.0101 0.0127 0.0232 0.0157 0.1617 0.748
Japan-Oita 11967 4 0.021 0.0383 0.0357 0.0133 0.1053 0.0625 0.5731 0.1507
Japan-Oita 11968 5 0.274 0.0194 0.0228 0.009 0.1373 0.0239 0.2583 0.2554
Japan-Oita 11969 5 0.0936 0.0207 0.1672 0.0084 0.0136 0.037 0.2395 0.4199
Japan-Oita 11970 16 0.019 0.0622 0.0634 0.0084 0.0164 0.0263 0.789 0.0153
Japan-Oita 11971 8 0.0111 0.0531 0.0573 0.0524 0.0256 0.4899 0.2553 0.0552
Japan-Oita 11972 3 0.0272 0.1819 0.1543 0.0177 0.0168 0.0868 0.3903 0.1249
Japan-Oita 11973 2 0.4089 0.007 0.0087 0.0072 0.0083 0.0138 0.0185 0.5276
Japan-Oita 11974 20 0.0084 0.012 0.0207 0.0139 0.0286 0.0498 0.3617 0.5049
Japan-Oita 11975 22 0.2289 0.0883 0.0279 0.006 0.021 0.078 0.4869 0.0631
Japan-Oita 11976 16 0.02 0.0092 0.0093 0.0171 0.0179 0.0433 0.5176 0.3656
Japan-Oita 11977 4 0.0072 0.0064 0.0048 0.0393 0.0498 0.0245 0.5591 0.3089
Japan-Oita 11979 12 0.1335 0.0164 0.0181 0.0454 0.0164 0.0077 0.6835 0.079
Japan-Oita 11980 21 0.0073 0.0185 0.0206 0.1152 0.0311 0.0344 0.6555 0.1173
Japan-Oita 11981 18 0.0059 0.0057 0.0063 0.0067 0.0131 0.0065 0.2067 0.749
Japan-Oita 11982 4 0.0151 0.02 0.0122 0.0359 0.0315 0.0153 0.3762 0.4938 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 8
Japan-Oita 11985 11 0.0182 0.0207 0.0232 0.0194 0.0077 0.016 0.2148 0.6799
Japan-Oita 11986 6 0.373 0.0219 0.0269 0.0133 0.0142 0.0311 0.4005 0.1191
Japan-Kanazawa 11929 6 0.9291 0.0104 0.0082 0.0119 0.0167 0.0109 0.0034 0.0094
Japan-Kanazawa 11931 20 0.0207 0.0098 0.0082 0.0283 0.0133 0.0323 0.0707 0.8167
Japan-Kanazawa 11932 6 0.0855 0.028 0.0167 0.0122 0.0159 0.0493 0.0933 0.6991
Japan-Kanazawa 11933 14 0.1065 0.0226 0.0316 0.005 0.0118 0.023 0.0168 0.7827
Japan-Kanazawa 11934 3 0.1539 0.0144 0.014 0.0031 0.01 0.0092 0.0249 0.7705
Japan-Kanazawa 11936 8 0.0408 0.0238 0.0173 0.0188 0.0136 0.09 0.3327 0.463
Japan-Kanazawa 11937 27 0.0204 0.0126 0.0089 0.0128 0.0235 0.0146 0.0137 0.8935
Japan-Kanazawa 11939 20 0.016 0.0055 0.0072 0.004 0.0344 0.0396 0.2948 0.5985
Japan-Kanazawa 11940 12 0.0119 0.0091 0.0074 0.0067 0.0188 0.0229 0.0872 0.836
Japan-Kanazawa 11941 6 0.0181 0.0114 0.0093 0.0071 0.0103 0.0489 0.2794 0.6155
Japan-Kanazawa 11942 9 0.0061 0.0037 0.0048 0.0045 0.0074 0.0064 0.0203 0.9468
Japan-Kanazawa 11943 17 0.0137 0.0175 0.0185 0.0315 0.0386 0.0523 0.4918 0.3361
Japan-Kanazawa 11944 7 0.3983 0.1001 0.1915 0.0224 0.0393 0.2042 0.0291 0.0151
Japan-Kanazawa 11945 18 0.0354 0.0111 0.0169 0.0069 0.0137 0.0272 0.0745 0.8143
Japan-Kanazawa 11946 16 0.0031 0.0031 0.0055 0.0031 0.0048 0.0068 0.0146 0.959
Japan-Ohmiya 11947 4 0.0618 0.0347 0.094 0.0089 0.006 0.0278 0.0664 0.7005
Japan-Ohmiya 11948 17 0.0042 0.0069 0.0065 0.0134 0.0081 0.0145 0.0152 0.9312
Japan-Ohmiya 11951 22 0.0305 0.0252 0.0508 0.0404 0.0717 0.0682 0.0182 0.6948
Japan-Ohmiya 11953 2 0.0057 0.0087 0.007 0.0075 0.0057 0.0103 0.2061 0.749
Japan-Ohmiya 11954 2 0.0462 0.0192 0.0192 0.0149 0.0076 0.0294 0.0259 0.8376
Japan-Ohmiya 11955 5 0.2035 0.015 0.0058 0.0133 0.0102 0.0115 0.0075 0.7332
Japan-Ohmiya 11956 2 0.0055 0.009 0.0343 0.0063 0.0117 0.0239 0.6507 0.2586
Japan-Ohmiya 11957 3 0.0187 0.0116 0.04 0.0058 0.2075 0.0208 0.0324 0.6631
Japan-Ohmiya 11959 4 0.011 0.0112 0.0096 0.0054 0.0107 0.0139 0.1684 0.7698
Japan-Ohmiya 11960 3 0.0066 0.0058 0.0055 0.0061 0.0093 0.0075 0.5186 0.4406
Japan-Ohmiya 11961 3 0.022 0.0123 0.0126 0.0081 0.0424 0.0181 0.1068 0.7777
Japan-Ohmiya 11962 4 0.2858 0.0341 0.0282 0.0099 0.1244 0.0417 0.067 0.4088
Japan-Ohmiya 11963 3 0.0125 0.0174 0.0152 0.0425 0.0909 0.056 0.0778 0.6876
Japan-Ohmiya 11964 4 0.0329 0.0136 0.0096 0.0109 0.0526 0.0321 0.0095 0.8388
Japan-Ohmiya 11965 4 0.0088 0.0207 0.0208 0.0111 0.381 0.2777 0.0351 0.2449
Japan-Ohmiya 11966 5 0.0452 0.053 0.0528 0.0525 0.0226 0.0939 0.0674 0.6125
Japan-Sapporo 11907 7 0.0364 0.0416 0.0118 0.0787 0.0528 0.0316 0.0609 0.6862
Japan-Sapporo 11909 9 0.9613 0.0058 0.0044 0.0057 0.0069 0.0056 0.005 0.0053
Japan-Sapporo 11911 17 0.2459 0.029 0.0119 0.0083 0.0166 0.1486 0.0251 0.5147
Japan-Sapporo 11913 16 0.0174 0.058 0.0467 0.0098 0.019 0.4068 0.157 0.2853
Japan-Sapporo 11914 4 0.012 0.0358 0.0505 0.0105 0.1369 0.3908 0.1625 0.201
Japan-Sapporo 11915 7 0.01 0.0066 0.006 0.0059 0.0088 0.0141 0.757 0.1915
Japan-Sapporo 11916 7 0.9309 0.0148 0.0163 0.0063 0.0064 0.0111 0.0109 0.0033
Japan-Sapporo 11917 4 0.9094 0.0145 0.0079 0.0298 0.0155 0.0086 0.005 0.0093
Japan-Sapporo 11918 13 0.0492 0.0158 0.0276 0.0232 0.0258 0.2314 0.0766 0.5504
Japan-Sapporo 11921 5 0.0053 0.0176 0.0244 0.0277 0.0676 0.0419 0.3003 0.5152
Japan-Sapporo 11922 6 0.0045 0.0057 0.0085 0.1235 0.4193 0.1359 0.0249 0.2776
Japan-Sapporo 11923 7 0.002 0.0037 0.0038 0.0046 0.0079 0.0055 0.3865 0.586
Japan-Sapporo 11924 6 0.5659 0.0661 0.0311 0.0065 0.013 0.0333 0.1571 0.127
Japan-Sapporo 11925 9 0.0071 0.0156 0.0112 0.0244 0.0368 0.0272 0.8529 0.0249
Japan-Sapporo 11926 11 0.041 0.3068 0.1245 0.0288 0.0075 0.017 0.0207 0.4536
China-Henan 8869 2 0.0031 0.0173 0.0141 0.0728 0.0267 0.0176 0.0062 0.8422
China-Henan 8870 0 0.0051 0.0107 0.0083 0.0139 0.0095 0.0124 0.007 0.9331
China-Henan 8871 0 0.0072 0.0145 0.0107 0.0127 0.0149 0.0183 0.0049 0.9168
China-Henan 8872 1 0.0096 0.0233 0.0223 0.0089 0.0087 0.0596 0.0081 0.8595
China-Henan 8873 1 0.0027 0.0065 0.006 0.0255 0.0043 0.0095 0.0043 0.9412
China-Henan 8874 8 0.004 0.0203 0.0096 0.0693 0.0166 0.0775 0.026 0.7768
China-Henan 8875 1 0.0031 0.0061 0.005 0.0099 0.0079 0.0068 0.0036 0.9576
China-Henan 8876 0 0.0032 0.0059 0.0058 0.0096 0.0074 0.0075 0.0046 0.956 Table 23 - Population clustering of each random bred individual in the database by
SNPs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
China-Henan 8877 0 0.0398 0.0179 0.0083 0.0151 0.0095 0.0141 0.0043 0.8911
China-Henan 8878 2 0.0057 0.0168 0.0133 0.024 0.0532 0.0121 0.004 0.8709
China-Henan 8879 2 0.0076 0.0089 0.0085 0.0067 0.0202 0.0226 0.0033 0.9222
China-Henan 8880 0 0.0492 0.0263 0.0167 0.0134 0.0133 0.0187 0.0034 0.859
China-Henan 8881 2 0.0046 0.0139 0.0091 0.0203 0.0713 0.0113 0.0052 0.8643
China-Henan 8882 2 0.0067 0.0125 0.009 0.0276 0.0057 0.0142 0.0052 0.9191
China-Henan 8883 0 0.0079 0.0073 0.0051 0.099 0.0061 0.0108 0.0071 0.8567
China-Henan 8884 0 0.0042 0.0055 0.0044 0.0183 0.0065 0.0054 0.0032 0.9525
China-Henan 8885 0 0.011 0.0548 0.0223 0.1045 0.0156 0.0245 0.0042 0.7631
China-Henan 8886 0 0.0036 0.0093 0.0065 0.0363 0.0093 0.0095 0.004 0.9215
China-Henan 8887 1 0.0041 0.0114 0.0114 0.0233 0.0122 0.0477 0.0186 0.8714
China-Henan 8888 1 0.0056 0.0048 0.0048 0.0061 0.009 0.0107 0.0029 0.9561
South Korea 2769 4 0.0072 0.0421 0.0367 0.0598 0.0161 0.0142 0.0083 0.8156
South Korea 2772 12 0.0053 0.0043 0.0043 0.0058 0.0074 0.0105 0.0049 0.9575
South Korea 2775 8 0.0077 0.0171 0.015 0.0299 0.0179 0.0225 0.0434 0.8465
South Korea 2776 25 0.0037 0.0062 0.0066 0.0162 0.0219 0.0106 0.0263 0.9085
South Korea 2779 0 0.017 0.0281 0.0133 0.0242 0.0734 0.0106 0.0255 0.8078
South Korea 2784 2 0.0074 0.029 0.0334 0.0394 0.0898 0.0494 0.0057 0.746
South Korea 2785 1 0.005 0.0068 0.0125 0.0145 0.0842 0.014 0.014 0.849
South Korea 2786 2 0.0055 0.0089 0.0108 0.0042 0.0064 0.0083 0.0226 0.9333
South Korea 7671 1 0.0629 0.0954 0.0266 0.0128 0.0074 0.0095 0.0066 0.7788
South Korea 7672 0 0.0043 0.0185 0.0101 0.0149 0.0122 0.0343 0.0522 0.8535
South Korea 7673 0 0.0078 0.0278 0.0259 0.0187 0.0102 0.0132 0.0056 0.8907
South Korea 7674 1 0.0524 0.0798 0.049 0.056 0.2326 0.0283 0.0061 0.4958
South Korea 7675 2 0.0045 0.0081 0.0056 0.008 0.0075 0.0069 0.0098 0.9496
South Korea 7676 2 0.1262 0.0274 0.0318 0.0066 0.0068 0.0227 0.0105 0.7681
South Korea 7677 14 0.8348 0.0273 0.0359 0.008 0.0105 0.0363 0.018 0.0291
South Korea 7678 0 0.0134 0.0081 0.0064 0.0084 0.0091 0.0166 0.0062 0.9318
South Korea 7679 2 0.0076 0.026 0.0171 0.0121 0.0113 0.0112 0.0104 0.9043
South Korea 7680 8 0.1295 0.0645 0.0252 0.0164 0.0099 0.0178 0.0049 0.7318
South Korea 7681 2 0.0096 0.0111 0.0106 0.0068 0.0053 0.0199 0.0238 0.9129
South Korea 7682 0 0.0037 0.005 0.0046 0.0051 0.0069 0.0084 0.0318 0.9345
South Korea 7683 0 0.0041 0.0054 0.0045 0.012 0.0167 0.0196 0.0045 0.9332
South Korea 7684 1 0.5642 0.0237 0.0143 0.0745 0.0554 0.0179 0.0073 0.2427
South Korea 7685 6 0.0109 0.0423 0.0363 0.0278 0.242 0.0438 0.0953 0.5016
South Korea 7686 2 0.0171 0.0165 0.0213 0.0202 0.0356 0.0095 0.0032 0.8766
South Korea 7687 4 0.0938 0.0308 0.0355 0.0087 0.0375 0.0152 0.0728 0.7057
South Korea 7688 13 0.3179 0.0088 0.0074 0.007 0.0088 0.0065 0.0112 0.6324
South Korea 7689 0 0.0041 0.0105 0.0046 0.0754 0.0105 0.0058 0.0035 0.8856
South Korea 7690 0 0.0275 0.092 0.0544 0.0206 0.0092 0.028 0.0088 0.7595
South Korea 7691 2 0.0045 0.0057 0.0069 0.0072 0.0065 0.0199 0.1218 0.8275
South Korea 7692 0 0.0355 0.0478 0.0443 0.0599 0.0246 0.0423 0.0105 0.7351
South Korea 7693 0 0.0089 0.0127 0.0161 0.0138 0.0918 0.0349 0.0177 0.8041
South Korea 7694 1 0.0032 0.0161 0.0076 0.0076 0.0396 0.0335 0.0269 0.8655
South Korea 7695 9 0.0515 0.0557 0.0928 0.0239 0.0143 0.0252 0.0032 0.7335
South Korea 7696 2 0.0073 0.0103 0.0095 0.0084 0.0103 0.0142 0.0041 0.9359
South Korea 7697 2 0.0357 0.0343 0.0234 0.0288 0.0502 0.0116 0.006 0.81
South Korea 7698 2 0.0112 0.0263 0.1216 0.007 0.0041 0.0243 0.3231 0.4825
South Korea 7699 0 0.0235 0.0274 0.0444 0.008 0.0058 0.0109 0.0186 0.8614
South Korea 7700 6 0.0052 0.0078 0.0104 0.0093 0.0059 0.0098 0.0161 0.9355 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
USA-NY 2547 2 0.72 0.045 0.006 0.044 0.173 0.004 0.008
USA-NY 2559 13 0.738 0.229 0.005 0.006 0.016 0.003 0.004
USA-NY 2568 2 0.96 0.007 0.005 0.005 0.01 0.012 0.003
USA-NY 2569 21 0.902 0.014 0.005 0.011 0.042 0.015 0.011
USA-NY 2572 5 0.876 0.014 0.047 0.042 0.009 0.008 0.005
USA-NY 2578 5 0.937 0.008 0.004 0.019 0.025 0.003 0.005
USA-NY 2590 5 0.929 0.025 0.006 0.014 0.02 0.004 0.002
USA-NY 2591 7 0.916 0.011 0.014 0.007 0.021 0.023 0.007
USA-NY 2597 15 0.845 0.011 0.006 0.11 0.011 0.006 0.01
USA-MS 9971 5 0.875 0.017 0.005 0.077 0.011 0.007 0.007
USA-MS 9972 0 0.785 0.01 0.01 0.096 0.078 0.008 0.013
USA-MS 9974 2 0.907 0.021 0.024 0.024 0.01 0.008 0.007
USA-MS 9977 10 0.916 0.01 0.004 0.029 0.018 0.013 0.01
USA-MS 9980 7 0.904 0.04 0.017 0.005 0.017 0.004 0.011
USA-MS 9983 7 0.946 0.008 0.011 0.018 0.008 0.004 0.005
USA-MS 9985 5 0.786 0.062 0.004 0.03 0.02 0.095 0.002
USA-MS 9987 10 0.897 0.026 0.006 0.031 0.023 0.006 0.011
USA-MS 9989 2 0.865 0.019 0.007 0.021 0.053 0.03 0.005
USA-MS 9992 7 0.687 0.097 0.012 0.075 0.114 0.009 0.006
USA-HI 5366 10 0.628 0.057 0.071 0.04 0.063 0.137 0.003
USA-HI 5367 7 0.574 0.011 0.011 0.055 0.333 0.008 0.008
USA-HI 5371 5 0.46 0.329 0.01 0.119 0.024 0.037 0.021
USA-HI 5372 7 0.74 0.041 0.012 0.165 0.023 0.012 0.007
USA-HI 5379 2 0.875 0.024 0.005 0.019 0.026 0.036 0.014
USA-HI 5380 2 0.915 0.009 0.016 0.005 0.038 0.012 0.005
USA-HI 5383 10 0.366 0.266 0.113 0.012 0.154 0.014 0.075
USA-HI 5384 18 0.753 0.13 0.016 0.004 0.088 0.003 0.005
USA-HI 5401 5 0.274 0.09 0.041 0.009 0.548 0.035 0.003
USA-HI 5402 7 0.714 0.064 0.008 0.018 0.063 0.086 0.046
Brazil 7961 2 0.944 0.009 0.004 0.003 0.028 0.008 0.003
Brazil 7962 2 0.885 0.089 0.006 0.005 0.01 0.003 0.002
Brazil 7963 23 0.805 0.012 0.026 0.137 0.01 0.005 0.004
Brazil 7964 5 0.945 0.007 0.021 0.006 0.007 0.009 0.004
Brazil 7965 65 0.954 0.008 0.008 0.009 0.011 0.005 0.006
Brazil 7966 5 0.955 0.006 0.004 0.007 0.013 0.004 0.011
Brazil 7968 23 0.952 0.013 0.005 0.007 0.011 0.006 0.006
Brazil 7969 2 0.968 0.007 0.004 0.008 0.006 0.004 0.003
Brazil 7970 2 0.956 0.01 0.01 0.009 0.008 0.003 0.003
Brazil 7971 2 0.967 0.004 0.005 0.004 0.007 0.008 0.004
Brazil 7972 2 0.962 0.005 0.008 0.003 0.011 0.004 0.006
Brazil 7973 2 0.921 0.007 0.009 0.004 0.045 0.01 0.004
Brazil 7974 2 0.952 0.009 0.009 0.007 0.011 0.006 0.005
Brazil 7975 13 0.94 0.007 0.009 0.01 0.017 0.013 0.003
Brazil 7976 2 0.975 0.004 0.004 0.003 0.005 0.005 0.003
Brazil 7977 7 0.956 0.009 0.005 0.003 0.017 0.007 0.003
Brazil 7978 2 0.942 0.007 0.032 0.005 0.006 0.004 0.003
Brazil 7979 5 0.933 0.009 0.017 0.007 0.013 0.017 0.005
Brazil 7980 2 0.63 0.065 0.005 0.009 0.252 0.02 0.019
Brazil 7981 5 0.798 0.023 0.01 0.023 0.015 0.124 0.007
Brazil 7982 42 0.843 0.039 0.02 0.037 0.026 0.026 0.009
Brazil 7983 15 0.74 0.022 0.007 0.195 0.026 0.005 0.006
Brazil 7984 50 0.588 0.061 0.011 0.106 0.118 0.097 0.019
Brazil 7985 21 0.956 0.009 0.012 0.006 0.008 0.004 0.004
Brazil 7986 10 0.911 0.033 0.006 0.017 0.009 0.018 0.007
Brazil 7987 5 0.84 0.01 0.012 0.096 0.032 0.006 0.004
Brazil 7988 2 0.821 0.045 0.013 0.071 0.02 0.01 0.021 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Brazil 7989 5 0.889 0.011 0.03 0.033 0.014 0.014 0.008
Brazil 7990 5 0.967 0.005 0.008 0.008 0.006 0.003 0.003
Finland 8077 23 0.961 0.006 0.004 0.003 0.017 0.003 0.006
Finland 8084 31 0.612 0.007 0.006 0.052 0.301 0.018 0.005
Finland 8086 13 0.914 0.027 0.006 0.004 0.04 0.004 0.005
Finland 8089 26 0.915 0.013 0.024 0.013 0.015 0.011 0.009
Finland 8093 18 0.441 0.046 0.006 0.003 0.499 0.003 0.003
Finland 8094 34 0.732 0.067 0.019 0.026 0.091 0.01 0.056
Finland 8096 23 0.555 0.019 0.007 0.005 0.402 0.004 0.008
Finland 8107 31 0.975 0.006 0.003 0.004 0.007 0.003 0.003
Finland 8110 28 0.213 0.029 0.006 0.109 0.622 0.009 0.011
Finland 8116 44 0.906 0.015 0.015 0.01 0.03 0.011 0.013
Finland 8120 28 0.685 0.033 0.004 0.005 0.254 0.01 0.01
Germany 8711 13 0.977 0.004 0.003 0.003 0.008 0.003 0.003
Germany 8712 2 0.946 0.004 0.008 0.011 0.007 0.01 0.014
Germany 8713 7 0.867 0.013 0.015 0.013 0.034 0.029 0.029
Germany 8714 5 0.933 0.009 0.004 0.01 0.028 0.005 0.012
Germany 8715 5 0.963 0.008 0.004 0.005 0.012 0.004 0.005
Germany 8716 2 0.966 0.008 0.005 0.004 0.011 0.003 0.004
Germany 8717 7 0.962 0.008 0.005 0.005 0.012 0.004 0.004
Germany 8720 5 0.398 0.007 0.004 0.569 0.007 0.01 0.004
Germany 8721 10 0.85 0.023 0.014 0.003 0.096 0.004 0.009
Germany 8727 7 0.719 0.162 0.011 0.008 0.091 0.004 0.005
Germany 8728 10 0.974 0.004 0.005 0.005 0.006 0.004 0.003
Germany 8729 7 0.975 0.007 0.003 0.003 0.008 0.002 0.002
Germany 8730 21 0.811 0.036 0.005 0.008 0.13 0.008 0.003
Germany 8731 13 0.933 0.016 0.004 0.005 0.032 0.006 0.004
Germany 8732 7 0.954 0.009 0.007 0.011 0.011 0.004 0.003
Germany 8733 23 0.907 0.007 0.048 0.007 0.015 0.008 0.007
Germany 8734 7 0.972 0.007 0.003 0.003 0.01 0.003 0.002
Germany 8735 7 0.936 0.006 0.002 0.01 0.038 0.004 0.003
Germany 8736 5 0.835 0.011 0.006 0.006 0.031 0.011 0.099
Germany 8737 10 0.709 0.016 0.025 0.019 0.201 0.013 0.016
Germany 8738 10 0.716 0.007 0.005 0.008 0.177 0.006 0.081
Germany 8739 7 0.952 0.005 0.015 0.006 0.015 0.004 0.004
Germany 8741 7 0.969 0.005 0.003 0.005 0.011 0.004 0.003
Germany 8742 7 0.968 0.004 0.002 0.004 0.012 0.007 0.003
Germany 8744 7 0.635 0.042 0.01 0.031 0.119 0.144 0.019
Germany 8745 26 0.779 0.025 0.01 0.01 0.163 0.005 0.007
Germany 8746 5 0.968 0.005 0.009 0.004 0.007 0.003 0.003
Germany 8747 18 0.957 0.009 0.004 0.008 0.012 0.008 0.003
Germany 8749 7 0.975 0.005 0.004 0.003 0.007 0.003 0.004
Italy-Milan 8050 5 0.469 0.016 0.005 0.053 0.166 0.271 0.019
Italy-Milan 8057 5 0.098 0.011 0.006 0.035 0.837 0.005 0.008
Italy-Milan 8060 2 0.65 0.074 0.03 0.021 0.215 0.006 0.005
Italy-Milan 8061 5 0.179 0.077 0.088 0.047 0.556 0.027 0.026
Italy-Milan 8062 10 0.412 0.195 0.013 0.012 0.349 0.013 0.006
Italy-Milan 8065 10 0.397 0.489 0.016 0.007 0.073 0.013 0.005
Italy-Milan 8066 2 0.873 0.005 0.008 0.068 0.037 0.005 0.004
Italy-Milan 8067 2 0.471 0.24 0.121 0.017 0.137 0.005 0.01
Italy-Milan 8068 7 0.126 0.061 0.012 0.015 0.773 0.008 0.006
Italy-Milan 8069 2 0.109 0.008 0.011 0.111 0.74 0.013 0.008
Italy-Milan 8071 5 0.933 0.011 0.02 0.007 0.017 0.007 0.005
Italy-Milan 8072 7 0.21 0.024 0.004 0.021 0.694 0.03 0.017
Italy-Milan 8073 5 0.612 0.081 0.003 0.064 0.205 0.014 0.021
Italy-Milan 8074 5 0.603 0.012 0.011 0.347 0.008 0.016 0.003 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Italy-Rome 8586 2 0.431 0.148 0.043 0.009 0.311 0.045 0.013
Italy-Rome 8589 7 0.633 0.103 0.007 0.012 0.187 0.053 0.005
Italy-Rome 8592 7 0.349 0.064 0.005 0.022 0.493 0.008 0.059
Italy-Rome 8594 2 0.728 0.017 0.007 0.014 0.165 0.006 0.064
Italy-Rome 8595 5 0.361 0.092 0.011 0.08 0.31 0.021 0.125
Italy-Rome 8596 2 0.481 0.135 0.016 0.011 0.31 0.039 0.009
Italy-Rome 8597 2 0.635 0.188 0.006 0.014 0.124 0.012 0.022
Italy-Rome 8599 5 0.609 0.27 0.003 0.016 0.045 0.052 0.004
Italy-Rome 8601 2 0.645 0.02 0.009 0.01 0.043 0.026 0.247
Italy-Rome 8602 5 0.616 0.104 0.007 0.011 0.243 0.008 0.01
Italy-Rome 8603 5 0.82 0.096 0.005 0.021 0.035 0.004 0.019
Italy-Rome 8604 7 0.602 0.012 0.01 0.019 0.107 0.23 0.02
Italy-Rome 8609 5 0.365 0.473 0.006 0.015 0.121 0.011 0.009
Italy-Rome 8610 7 0.672 0.037 0.008 0.005 0.27 0.005 0.004
Italy-Rome 8611 2 0.604 0.097 0.011 0.005 0.215 0.008 0.06
Turkey 6477 5 0.013 0.109 0.003 0.004 0.843 0.007 0.021
Turkey 6478 10 0.016 0.532 0.005 0.007 0.424 0.004 0.012
Turkey 6480 7 0.101 0.461 0.028 0.024 0.369 0.009 0.008
Turkey 6481 5 0.027 0.009 0.007 0.891 0.054 0.009 0.004
Turkey 6482 7 0.165 0.017 0.015 0.033 0.731 0.014 0.025
Turkey 6484 5 0.021 0.024 0.024 0.006 0.913 0.006 0.005
Turkey 6486 5 0.014 0.01 0.011 0.014 0.931 0.005 0.016
Turkey 6487 7 0.01 0.025 0.002 0.004 0.95 0.005 0.004
Turkey 6488 7 0.048 0.361 0.004 0.02 0.532 0.016 0.018
Turkey 6491 13 0.3 0.043 0.011 0.289 0.012 0.342 0.003
Turkey 6494 7 0.17 0.069 0.005 0.009 0.694 0.017 0.037
Turkey 6496 5 0.08 0.037 0.019 0.09 0.756 0.013 0.006
Turkey 6499 7 0.277 0.032 0.081 0.005 0.582 0.015 0.008
Turkey 6500 15 0.029 0.037 0.004 0.003 0.92 0.004 0.004
Turkey 6502 7 0.058 0.209 0.032 0.007 0.674 0.016 0.006
Turkey 6503 10 0.054 0.013 0.005 0.034 0.879 0.011 0.004
Turkey 6507 5 0.038 0.05 0.003 0.005 0.887 0.011 0.006
Turkey 6510 5 0.616 0.017 0.003 0.004 0.35 0.008 0.002
Turkey 6512 7 0.012 0.031 0.015 0.009 0.898 0.026 0.008
Turkey 6513 5 0.059 0.338 0.064 0.029 0.457 0.007 0.046
Turkey 6514 5 0.015 0.006 0.005 0.87 0.014 0.084 0.006
Turkey 6516 5 0.935 0.009 0.017 0.007 0.021 0.002 0.008
Turkey 6519 5 0.081 0.071 0.006 0.007 0.824 0.005 0.007
Turkey 6520 5 0.105 0.041 0.003 0.009 0.834 0.004 0.003
Turkey 6521 7 0.027 0.015 0.01 0.006 0.916 0.019 0.008
Turkey 6729 5 0.01 0.026 0.038 0.01 0.513 0.04 0.364
Turkey 6730 5 0.14 0.039 0.012 0.005 0.772 0.027 0.005
Turkey 6731 7 0.278 0.022 0.005 0.007 0.664 0.003 0.02
Turkey 6732 7 0.076 0.034 0.02 0.087 0.632 0.055 0.096
Turkey 6733 7 0.022 0.016 0.005 0.015 0.92 0.016 0.006
Turkey 6734 5 0.067 0.022 0.009 0.025 0.837 0.036 0.004
Turkey 6735 7 0.004 0.011 0.005 0.004 0.965 0.004 0.006
Turkey 6736 2 0.057 0.494 0.004 0.007 0.419 0.005 0.013
Turkey 6738 7 0.015 0.062 0.013 0.011 0.871 0.013 0.015
Turkey 6739 13 0.129 0.031 0.012 0.011 0.794 0.006 0.017
Turkey 6740 5 0.979 0.003 0.005 0.004 0.004 0.003 0.003
Turkey 6741 7 0.012 0.006 0.007 0.948 0.013 0.011 0.003
Turkey 6742 13 0.017 0.012 0.004 0.049 0.895 0.014 0.008
Turkey 6743 5 0.122 0.037 0.014 0.022 0.778 0.008 0.02
Turkey 6745 7 0.647 0.028 0.006 0.005 0.275 0.028 0.012
Turkey 6746 5 0.21 0.019 0.009 0.361 0.348 0.035 0.017 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Turkey 6748 10 0.081 0.213 0.011 0.012 0.668 0.005 0.009
Turkey 6749 10 0.737 0.016 0.002 0.006 0.183 0.008 0.048
Turkey 6750 5 0.156 0.018 0.007 0.003 0.811 0.003 0.002
Turkey 6753 10 0.041 0.031 0.007 0.043 0.768 0.076 0.033
Turkey 6754 10 0.016 0.007 0.004 0.005 0.93 0.003 0.034
Turkey 6755 10 0.265 0.167 0.004 0.012 0.515 0.027 0.011
Turkey 6756 10 0.214 0.021 0.005 0.004 0.748 0.003 0.005
Turkey 6758 13 0.045 0.054 0.007 0.009 0.83 0.03 0.025
Turkey 6759 13 0.021 0.108 0.012 0.012 0.833 0.01 0.004
Turkey 6760 7 0.121 0.014 0.023 0.006 0.826 0.005 0.007
Cyprus 10128 2 0.024 0.018 0.011 0.008 0.905 0.028 0.006
Cyprus 10129 5 0.176 0.174 0.012 0.005 0.624 0.003 0.005
Cyprus 10130 7 0.097 0.017 0.013 0.013 0.85 0.006 0.004
Cyprus 10131 2 0.016 0.258 0.006 0.175 0.516 0.013 0.015
Cyprus 10132 2 0.034 0.176 0.031 0.019 0.717 0.008 0.014
Cyprus 10133 15 0.046 0.032 0.015 0.009 0.88 0.005 0.014
Cyprus 10134 5 0.01 0.301 0.046 0.008 0.61 0.005 0.021
Cyprus 10135 5 0.028 0.565 0.062 0.075 0.251 0.015 0.004
Cyprus 10136 5 0.171 0.069 0.043 0.01 0.651 0.023 0.034
Cyprus 10137 2 0.034 0.061 0.007 0.005 0.592 0.023 0.278
Cyprus 10138 2 0.015 0.521 0.013 0.012 0.394 0.01 0.035
Cyprus 10139 2 0.011 0.524 0.031 0.295 0.08 0.018 0.041
Cyprus 10140 0 0.02 0.04 0.011 0.007 0.904 0.004 0.014
Cyprus 10141 5 0.469 0.128 0.013 0.008 0.343 0.013 0.025
Cyprus 10142 2 0.006 0.056 0.055 0.011 0.831 0.027 0.013
Cyprus 10143 5 0.015 0.596 0.005 0.004 0.352 0.011 0.016
Cyprus 10144 7 0.023 0.111 0.012 0.014 0.831 0.005 0.004
Cyprus 10145 5 0.021 0.018 0.003 0.003 0.946 0.004 0.005
Cyprus 10146 0 0.007 0.786 0.025 0.028 0.138 0.01 0.006
Cyprus 10147 5 0.013 0.016 0.004 0.004 0.957 0.002 0.003
Cyprus 10148 7 0.03 0.775 0.015 0.05 0.075 0.032 0.023
Cyprus 10149 7 0.191 0.066 0.044 0.009 0.502 0.011 0.178
Cyprus 10150 2 0.015 0.693 0.006 0.028 0.237 0.007 0.014
Cyprus 10151 2 0.012 0.029 0.004 0.012 0.909 0.011 0.022
Cyprus 10152 5 0.014 0.709 0.006 0.044 0.175 0.039 0.013
Cyprus 10153 0 0.007 0.013 0.004 0.007 0.951 0.008 0.009
Cyprus 10154 0 0.033 0.467 0.011 0.087 0.272 0.009 0.121
Cyprus 10155 5 0.009 0.034 0.086 0.029 0.826 0.011 0.005
Cyprus 10156 7 0.107 0.373 0.005 0.018 0.39 0.089 0.018
Cyprus 10157 2 0.008 0.908 0.006 0.006 0.045 0.006 0.021
Lebanon 10235 10 0.073 0.732 0.016 0.049 0.064 0.03 0.036
Lebanon 10236 13 0.019 0.036 0.014 0.035 0.84 0.041 0.014
Lebanon 10237 5 0.021 0.4 0.072 0.226 0.22 0.053 0.009
Lebanon 10238 5 0.01 0.82 0.012 0.029 0.073 0.009 0.047
Lebanon 10239 5 0.012 0.348 0.006 0.009 0.611 0.008 0.007
Lebanon 10240 15 0.02 0.216 0.009 0.089 0.615 0.024 0.027
Lebanon 10241 13 0.04 0.018 0.015 0.028 0.81 0.064 0.025
Lebanon 10242 7 0.049 0.281 0.024 0.009 0.607 0.005 0.026
Lebanon 10243 10 0.021 0.082 0.022 0.043 0.732 0.032 0.067
Lebanon 10244 5 0.013 0.065 0.012 0.035 0.76 0.035 0.08
Lebanon 10245 13 0.047 0.167 0.034 0.027 0.459 0.008 0.258
Lebanon 10246 2 0.01 0.905 0.009 0.011 0.045 0.003 0.016
Lebanon 10247 18 0.012 0.598 0.013 0.009 0.067 0.008 0.293
Lebanon 10248 7 0.1 0.804 0.024 0.005 0.055 0.005 0.007
Lebanon 10249 13 0.538 0.035 0.01 0.018 0.384 0.008 0.007
Lebanon 10250 2 0.026 0.046 0.007 0.005 0.786 0.017 0.113 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Lebanon 10251 2 0.094 0.793 0.012 0.007 0.08 0.004 0.01
Lebanon 10252 5 0.086 0.027 0.011 0.006 0.83 0.009 0.031
Lebanon 10253 15 0.041 0.854 0.005 0.003 0.088 0.004 0.006
Lebanon 10254 13 0.008 0.053 0.011 0.031 0.865 0.015 0.017
Lebanon 10255 7 0.05 0.648 0.01 0.015 0.1 0.018 0.16
Lebanon 10256 18 0.008 0.827 0.006 0.005 0.14 0.007 0.008
Lebanon 10257 5 0.004 0.114 0.048 0.02 0.74 0.013 0.062
Lebanon 10258 7 0.024 0.408 0.022 0.01 0.518 0.007 0.012
Lebanon 10259 10 0.078 0.066 0.017 0.791 0.032 0.008 0.008
Lebanon 10260 2 0.005 0.053 0.02 0.006 0.891 0.007 0.018
Lebanon 10261 10 0.047 0.225 0.008 0.011 0.634 0.011 0.064
Lebanon 10262 5 0.087 0.169 0.015 0.034 0.612 0.041 0.041
Lebanon 10263 7 0.008 0.424 0.005 0.022 0.528 0.005 0.008
Lebanon 10264 5 0.018 0.015 0.009 0.03 0.908 0.01 0.01
Lebanon 10265 7 0.014 0.428 0.007 0.007 0.428 0.007 0.109
Lebanon 10266 0 0.032 0.736 0.03 0.105 0.073 0.012 0.012
Lebanon 10267 18 0.099 0.575 0.004 0.007 0.303 0.006 0.006
Lebanon 10268 5 0.025 0.781 0.01 0.042 0.128 0.011 0.003
Lebanon 10270 13 0.023 0.58 0.012 0.184 0.049 0.065 0.088
Lebanon 10271 18 0.18 0.011 0.049 0.082 0.545 0.026 0.107
Lebanon 10273 10 0.186 0.116 0.019 0.029 0.567 0.039 0.044
Lebanon 10274 13 0.027 0.164 0.037 0.53 0.204 0.032 0.007
Lebanon 10276 10 0.011 0.887 0.007 0.022 0.062 0.003 0.008
Lebanon 10277 2 0.072 0.27 0.005 0.02 0.43 0.162 0.04
Lebanon 10278 15 0.023 0.208 0.067 0.011 0.645 0.035 0.011
Lebanon 10279 0 0.008 0.066 0.026 0.031 0.837 0.007 0.025
Lebanon 10280 0 0.021 0.061 0.044 0.232 0.589 0.015 0.038
Lebanon 10281 10 0.007 0.424 0.007 0.007 0.509 0.008 0.038
Lebanon 10282 10 0.01 0.753 0.011 0.062 0.142 0.007 0.016
Lebanon 10283 23 0.007 0.012 0.077 0.005 0.888 0.005 0.006
Lebanon 10284 23 0.032 0.125 0.213 0.036 0.514 0.022 0.057
Lebanon 10285 2 0.035 0.131 0.017 0.019 0.676 0.111 0.011
Lebanon 10286 15 0.009 0.088 0.007 0.169 0.446 0.013 0.268
Lebanon 10287 5 0.142 0.04 0.036 0.08 0.629 0.043 0.03
Lebanon 10288 13 0.949 0.017 0.003 0.005 0.018 0.007 0.002
Lebanon 10289 13 0.008 0.547 0.008 0.019 0.389 0.007 0.022
Lebanon 10290 5 0.008 0.077 0.236 0.082 0.484 0.089 0.023
Lebanon 10291 15 0.011 0.089 0.03 0.013 0.69 0.045 0.122
Lebanon 10292 13 0.013 0.028 0.032 0.161 0.681 0.028 0.057
Lebanon 10294 2 0.066 0.289 0.023 0.095 0.455 0.025 0.047
Lebanon 10295 7 0.055 0.594 0.066 0.033 0.167 0.018 0.067
Lebanon 10297 5 0.01 0.027 0.007 0.015 0.813 0.021 0.108
Lebanon 10298 10 0.013 0.108 0.061 0.036 0.249 0.021 0.51
Lebanon 10299 2 0.246 0.057 0.208 0.034 0.342 0.083 0.03
Lebanon 10300 2 0.008 0.03 0.005 0.028 0.893 0.009 0.027
Israel 4962 7 0.009 0.029 0.013 0.008 0.904 0.004 0.034
Israel 4963 5 0.007 0.021 0.006 0.02 0.92 0.014 0.012
Israel 4964 7 0.201 0.042 0.006 0.016 0.693 0.009 0.033
Israel 4966 5 0.017 0.139 0.025 0.022 0.785 0.005 0.006
Israel 4967 5 0.052 0.021 0.019 0.015 0.784 0.097 0.012
Israel 4968 7 0.009 0.011 0.008 0.025 0.912 0.022 0.013
Israel 4969 2 0.076 0.014 0.015 0.022 0.831 0.032 0.01
Israel 4970 7 0.026 0.018 0.013 0.045 0.867 0.012 0.02
Israel 4971 2 0.006 0.005 0.006 0.014 0.929 0.022 0.019
Israel 4972 10 0.013 0.009 0.046 0.007 0.903 0.015 0.006
Israel 4973 5 0.006 0.009 0.026 0.005 0.942 0.006 0.005 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Israel 4974 5 0.015 0.009 0.006 0.012 0.945 0.005 0.009
Israel 4975 2 0.015 0.01 0.004 0.011 0.949 0.004 0.006
Israel 4976 5 0.072 0.037 0.04 0.021 0.817 0.004 0.009
Israel 4977 15 0.067 0.016 0.006 0.006 0.89 0.004 0.012
Israel 4978 10 0.017 0.005 0.009 0.013 0.928 0.007 0.021
Israel 4979 7 0.012 0.023 0.005 0.005 0.941 0.007 0.007
Israel 4980 2 0.084 0.093 0.011 0.118 0.458 0.106 0.129
Israel 4981 15 0.009 0.22 0.006 0.009 0.588 0.136 0.032
Israel 4982 10 0.066 0.008 0.014 0.019 0.882 0.006 0.005
Israel 4983 7 0.784 0.019 0.005 0.072 0.035 0.06 0.025
Israel 4984 2 0.924 0.006 0.005 0.029 0.009 0.022 0.005
Israel 4985 21 0.009 0.028 0.005 0.084 0.851 0.014 0.009
Israel 4986 5 0.004 0.008 0.007 0.005 0.959 0.009 0.008
Israel 4988 13 0.009 0.013 0.015 0.013 0.919 0.012 0.019
Israel 4989 5 0.006 0.141 0.005 0.137 0.647 0.009 0.055
Israel 4990 5 0.015 0.06 0.003 0.058 0.839 0.016 0.008
Israel 4992 7 0.018 0.009 0.005 0.005 0.956 0.004 0.004
Israel 4993 7 0.006 0.009 0.028 0.004 0.941 0.005 0.006
Israel 4994 5 0.004 0.008 0.003 0.003 0.974 0.004 0.003
Israel 4995 5 0.009 0.031 0.003 0.063 0.849 0.01 0.034
Israel 4996 2 0.009 0.149 0.003 0.01 0.803 0.014 0.013
Israel 4997 15 0.006 0.036 0.005 0.023 0.873 0.007 0.049
Israel 4998 10 0.034 0.011 0.005 0.018 0.916 0.007 0.01
Israel 5000 7 0.011 0.039 0.01 0.16 0.758 0.011 0.011
Israel 5001 5 0.041 0.049 0.006 0.014 0.856 0.007 0.028
Israel 5002 7 0.028 0.068 0.025 0.01 0.855 0.007 0.007
Israel 5003 7 0.023 0.019 0.012 0.005 0.914 0.019 0.007
Israel 5004 15 0.172 0.035 0.014 0.11 0.651 0.008 0.011
Israel 5005 7 0.022 0.017 0.011 0.01 0.927 0.004 0.008
Israel 5006 10 0.014 0.057 0.005 0.004 0.908 0.005 0.007
Israel 5007 5 0.208 0.034 0.027 0.071 0.463 0.192 0.005
Israel 5008 5 0.018 0.223 0.037 0.008 0.682 0.008 0.024
Israel 5009 13 0.277 0.138 0.006 0.106 0.371 0.034 0.067
Israel 5010 15 0.01 0.023 0.004 0.004 0.951 0.004 0.004
Israel 5011 13 0.019 0.011 0.009 0.012 0.926 0.006 0.016
Egypt-Cairo 8190 15 0.045 0.903 0.022 0.009 0.011 0.005 0.006
Egypt-Cairo 8192 18 0.1 0.682 0.066 0.077 0.027 0.012 0.037
Egypt-Cairo 8193 18 0.007 0.895 0.013 0.005 0.054 0.004 0.023
Egypt-Cairo 8196 15 0.009 0.875 0.008 0.038 0.041 0.021 0.009
Egypt-Cairo 8203 15 0.014 0.886 0.004 0.031 0.037 0.022 0.006
Egypt-Cairo 8215 10 0.005 0.955 0.003 0.007 0.021 0.004 0.005
Egypt-Cairo 8198 10 0.055 0.872 0.026 0.009 0.017 0.011 0.01
Egypt-Cairo 8194 7 0.101 0.82 0.025 0.008 0.023 0.013 0.01
Egypt-Cairo 8211 5 0.014 0.384 0.005 0.008 0.555 0.008 0.026
Egypt-Cairo 8216 7 0.312 0.633 0.01 0.006 0.023 0.008 0.009
Egypt-Cairo 8195 5 0.011 0.708 0.028 0.039 0.15 0.04 0.024
Egypt-Cairo 8199 2 0.005 0.917 0.041 0.007 0.022 0.004 0.005
Egypt-Cairo 8200 5 0.04 0.351 0.003 0.004 0.581 0.007 0.013
Egypt-Cairo 8201 5 0.014 0.036 0.042 0.009 0.729 0.095 0.076
Egypt-Cairo 8202 5 0.018 0.045 0.008 0.886 0.018 0.011 0.015
Egypt-Cairo 8204 5 0.019 0.781 0.009 0.031 0.139 0.016 0.006
Egypt-Cairo 8208 2 0.111 0.69 0.011 0.017 0.09 0.069 0.012
Egypt-Cairo 8210 5 0.007 0.86 0.019 0.02 0.053 0.004 0.037
Egypt-Cairo 8214 2 0.004 0.976 0.003 0.003 0.006 0.004 0.004
Egypt-Cairo 8191 5 0.034 0.534 0.018 0.032 0.254 0.083 0.046
Egypt-Cairo 8197 2 0.006 0.698 0.108 0.017 0.14 0.007 0.024 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Egypt-Cairo 8205 2 0.088 0.597 0.009 0.055 0.224 0.018 0.008
Egypt-Cairo 8206 2 0.068 0.744 0.008 0.031 0.134 0.01 0.006
Egypt-Cairo 8207 2 0.014 0.913 0.034 0.012 0.008 0.014 0.006
Egypt-Cairo 8209 2 0.075 0.824 0.003 0.004 0.082 0.007 0.005
Egypt-Cairo 8212 2 0.004 0.976 0.002 0.004 0.005 0.005 0.005
Egypt-Cairo 8213 2 0.007 0.968 0.003 0.004 0.007 0.005 0.006
Egypt-Cairo 9942 0 0.009 0.678 0.006 0.017 0.03 0.022 0.239
Egypt-Cairo 9943 15 0.2 0.006 0.003 0.669 0.006 0.109 0.007
Egypt-Cairo 9944 7 0.051 0.753 0.006 0.007 0.151 0.003 0.03
Egypt-Cairo 9945 2 0.107 0.845 0.007 0.009 0.015 0.006 0.01
Egypt-Cairo 9946 13 0.017 0.514 0.061 0.06 0.283 0.039 0.027
Egypt-Cairo 9947 7 0.018 0.868 0.019 0.007 0.05 0.007 0.03
Egypt-Cairo 9948 0 0.035 0.908 0.005 0.012 0.026 0.008 0.006
Egypt-Cairo 9949 0 0.029 0.917 0.007 0.01 0.018 0.011 0.008
Egypt-Cairo 9950 0 0.085 0.578 0.046 0.026 0.24 0.015 0.01
Egypt-Cairo 9951 5 0.009 0.055 0.012 0.005 0.907 0.008 0.003
Egypt-Cairo 9952 15 0.159 0.104 0.01 0.008 0.705 0.007 0.008
Egypt-Cairo 9953 21 0.06 0.048 0.008 0.01 0.828 0.005 0.041
Egypt-Cairo 9954 2 0.013 0.132 0.028 0.008 0.715 0.099 0.005
Egypt-Cairo 9955 0 0.506 0.166 0.006 0.212 0.077 0.027 0.005
Egypt-Cairo 9956 18 0.018 0.141 0.007 0.007 0.783 0.034 0.01
Egypt-Cairo 9957 5 0.014 0.886 0.005 0.011 0.011 0.066 0.006
Egypt-Cairo 9958 15 0.04 0.808 0.045 0.015 0.056 0.032 0.005
Egypt-Cairo 9959 5 0.137 0.093 0.006 0.065 0.663 0.017 0.017
Egypt-Cairo 9960 2 0.025 0.807 0.004 0.009 0.064 0.03 0.061
Egypt-Cairo 9961 5 0.066 0.319 0.006 0.556 0.027 0.018 0.008
Egypt-Cairo 9962 7 0.017 0.724 0.106 0.008 0.071 0.009 0.065
Egypt-Cairo 9963 2 0.031 0.808 0.032 0.01 0.096 0.014 0.008
Egypt-Cairo 9964 0 0.021 0.913 0.004 0.022 0.027 0.007 0.005
Egypt-Cairo 10021 0 0.005 0.96 0.01 0.004 0.009 0.004 0.007
Egypt-Cairo 10022 0 0.016 0.939 0.005 0.008 0.014 0.015 0.004
Egypt-Cairo 10023 0 0.005 0.947 0.007 0.012 0.019 0.006 0.003
Egypt-Cairo 10024 0 0.064 0.875 0.006 0.005 0.035 0.009 0.007
Egypt-Cairo 10025 0 0.04 0.035 0.006 0.009 0.891 0.003 0.015
Egypt-Cairo 10026 2 0.02 0.603 0.019 0.005 0.309 0.038 0.007
Egypt-Cairo 10027 0 0.063 0.649 0.223 0.022 0.02 0.01 0.012
Egypt-Cairo 10028 0 0.004 0.952 0.006 0.006 0.01 0.007 0.016
Egypt-Cairo 10029 0 0.004 0.968 0.006 0.003 0.006 0.004 0.01
Egypt-Cairo 10030 0 0.046 0.879 0.004 0.01 0.04 0.014 0.006
Egypt-Cairo 10031 2 0.003 0.961 0.01 0.004 0.007 0.003 0.012
Egypt-Cairo 10032 0 0.004 0.964 0.005 0.004 0.005 0.003 0.014
Egypt-Cairo 10033 2 0.004 0.95 0.008 0.01 0.016 0.009 0.004
Egypt-Cairo 10034 0 0.006 0.967 0.008 0.004 0.007 0.004 0.004
Egypt-Cairo 10035 0 0.007 0.763 0.086 0.009 0.021 0.107 0.007
Egypt-Cairo 10037 5 0.054 0.842 0.068 0.009 0.012 0.006 0.008
Egypt-Cairo 10042 0 0.031 0.747 0.035 0.034 0.108 0.018 0.027
Egypt-Cairo 10043 7 0.032 0.892 0.005 0.012 0.047 0.003 0.008
Egypt-Cairo 10044 2 0.014 0.934 0.005 0.008 0.027 0.006 0.005
Egypt-Cairo 10045 2 0.011 0.929 0.02 0.012 0.013 0.008 0.008
Egypt-Cairo 10046 0 0.017 0.912 0.006 0.022 0.018 0.021 0.004
Egypt-Cairo 10047 0 0.009 0.938 0.004 0.015 0.01 0.012 0.013
Egypt-Cairo 10048 2 0.031 0.927 0.005 0.013 0.012 0.011 0.002
Egypt-Cairo 10083 21 0.057 0.684 0.006 0.013 0.228 0.007 0.005
Egypt-Cairo 10040 0 0.301 0.252 0.024 0.019 0.365 0.027 0.011
Egypt-Cairo 10041 0 0.4 0.331 0.02 0.018 0.203 0.022 0.007
Egypt-Cairo 10049 5 0.015 0.901 0.011 0.016 0.02 0.015 0.022 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Egypt-Cairo 10084 2 0.012 0.456 0.037 0.015 0.461 0.01 0.009
Egypt-Cairo 10085 23 0.047 0.321 0.052 0.02 0.544 0.009 0.008
Egypt-Cairo 10087 5 0.007 0.936 0.005 0.005 0.04 0.005 0.002
Egypt-Cairo 10090 7 0.017 0.667 0.029 0.02 0.214 0.046 0.008
Egypt-Cairo 9968 0 0.022 0.929 0.01 0.007 0.014 0.004 0.014
Egypt-Asuit 10091 2 0.015 0.955 0.003 0.006 0.012 0.005 0.004
Egypt-Asuit 10093 0 0.008 0.966 0.012 0.003 0.005 0.004 0.003
Egypt-Asuit 10094 5 0.007 0.963 0.008 0.007 0.007 0.005 0.004
Egypt-Asuit 10095 2 0.009 0.927 0.009 0.008 0.033 0.003 0.01
Egypt-Asuit 10096 0 0.007 0.967 0.004 0.005 0.006 0.008 0.003
Egypt-Asuit 10098 0 0.005 0.974 0.006 0.003 0.005 0.004 0.003
Egypt-Asuit 10099 5 0.004 0.968 0.011 0.003 0.006 0.005 0.003
Egypt-Asuit 10100 2 0.069 0.321 0.182 0.015 0.315 0.069 0.03
Egypt-Asuit 10101 2 0.011 0.901 0.01 0.012 0.025 0.02 0.021
Egypt-Asuit 10102 0 0.005 0.742 0.007 0.215 0.013 0.011 0.007
Egypt-Luxor 10038 0 0.008 0.928 0.006 0.017 0.011 0.026 0.005
Egypt-Luxor 10039 2 0.005 0.96 0.004 0.003 0.007 0.003 0.019
Egypt-Luxor 10050 2 0.009 0.887 0.019 0.014 0.017 0.043 0.01
Egypt-Luxor 10051 0 0.008 0.934 0.011 0.005 0.036 0.003 0.004
Egypt-Luxor 10052 0 0.012 0.882 0.016 0.049 0.023 0.009 0.009
Egypt-Luxor 10053 0 0.023 0.419 0.016 0.023 0.449 0.004 0.066
Egypt-Luxor 10054 0 0.015 0.858 0.003 0.013 0.022 0.081 0.008
Egypt-Luxor 10055 0 0.01 0.917 0.025 0.006 0.029 0.005 0.008
Egypt-Luxor 10056 0 0.006 0.919 0.01 0.006 0.014 0.03 0.015
Egypt-Luxor 10057 7 0.016 0.632 0.007 0.019 0.223 0.033 0.07
Egypt-Luxor 10058 0 0.01 0.949 0.01 0.003 0.016 0.006 0.006
Egypt-Luxor 10060 0 0.033 0.195 0.01 0.005 0.741 0.009 0.007
Egypt-Luxor 10061 0 0.012 0.479 0.03 0.044 0.013 0.417 0.005
Egypt-Luxor 10062 5 0.036 0.901 0.007 0.007 0.028 0.016 0.007
Egypt-Luxor 10063 2 0.022 0.642 0.028 0.023 0.188 0.016 0.082
Egypt-Luxor 10064 0 0.013 0.72 0.206 0.01 0.031 0.013 0.007
Egypt-Luxor 10065 0 0.024 0.729 0.204 0.013 0.015 0.005 0.009
Egypt-Luxor 10066 2 0.032 0.856 0.038 0.014 0.015 0.037 0.008
Egypt-Luxor 10067 2 0.006 0.931 0.006 0.005 0.032 0.003 0.016
Egypt-Luxor 10068 0 0.011 0.806 0.006 0.038 0.041 0.095 0.003
Egypt-Luxor 10069 2 0.007 0.936 0.018 0.008 0.018 0.005 0.008
Egypt-Luxor 10070 0 0.015 0.5 0.027 0.041 0.012 0.4 0.005
Egypt-Luxor 10071 2 0.012 0.575 0.015 0.034 0.223 0.123 0.018
Egypt-Luxor 10072 2 0.008 0.867 0.009 0.005 0.073 0.032 0.006
Egypt-Luxor 10073 5 0.926 0.038 0.008 0.008 0.01 0.006 0.005
Egypt-Luxor 10074 0 0.007 0.785 0.008 0.004 0.185 0.007 0.004
Egypt-Luxor 10079 0 0.088 0.607 0.011 0.191 0.09 0.004 0.009
Egypt-Luxor 10080 0 0.044 0.55 0.314 0.033 0.038 0.012 0.009
Egypt-Abu Simbel 10076 5 0.015 0.81 0.027 0.015 0.074 0.054 0.006
Egypt-Abu Simbel 10077 13 0.005 0.906 0.017 0.036 0.017 0.013 0.005
Egypt-Abu Simbel 10081 7 0.013 0.655 0.023 0.016 0.268 0.018 0.007
Egypt-Abu Simbel 10089 0 0.116 0.761 0.027 0.004 0.086 0.003 0.003
Egypt-Abu Simbel 10092 0 0.005 0.957 0.01 0.004 0.011 0.008 0.004
Iraq-West 9587 0 0.02 0.056 0.017 0.096 0.062 0.012 0.736
Iraq-West 10202 23 0.01 0.012 0.006 0.012 0.316 0.009 0.636
Iraq-West 10204 23 0.037 0.102 0.009 0.008 0.086 0.004 0.754
Iraq-West 11854 0 0.007 0.027 0.003 0.009 0.041 0.025 0.888
Iraq-West 11860 21 0.004 0.012 0.012 0.06 0.013 0.005 0.892
Iraq-West 11861 7 0.011 0.082 0.012 0.009 0.107 0.246 0.534
Iraq-West 11863 21 0.016 0.006 0.006 0.01 0.009 0.011 0.943
Iraq-West 11864 2 0.005 0.018 0.006 0.026 0.022 0.023 0.9 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Iraq-West 11888 5 0.003 0.004 0.122 0.007 0.005 0.01 0.85
Iraq-West 11889 7 0.187 0.014 0.012 0.017 0.058 0.012 0.7
Iraq-West 11890 2 0.008 0.231 0.041 0.008 0.016 0.068 0.629
Iraq-West 11891 0 0.019 0.06 0.01 0.007 0.282 0.007 0.616
Iraq-Baghdad 11847 5 0.01 0.038 0.006 0.022 0.082 0.01 0.832
Iraq-Baghdad 11848 0 0.01 0.013 0.011 0.111 0.015 0.059 0.78
Iraq-Baghdad 11849 5 0.01 0.127 0.004 0.047 0.017 0.033 0.761
Iraq-Baghdad 11850 0 0.039 0.016 0.004 0.015 0.011 0.016 0.899
Iraq-Baghdad 11852 0 0.01 0.02 0.057 0.021 0.025 0.013 0.854
Iraq-Baghdad 11853 5 0.006 0.015 0.008 0.026 0.014 0.017 0.913
Iraq-Baghdad 11855 5 0.006 0.013 0.067 0.015 0.062 0.013 0.824
Iraq-Baghdad 11856 2 0.027 0.026 0.016 0.012 0.072 0.005 0.844
Iraq-Baghdad 11857 0 0.173 0.156 0.007 0.011 0.084 0.011 0.558
Iraq-Baghdad 11858 2 0.008 0.008 0.004 0.01 0.011 0.005 0.954
Iraq-Baghdad 11859 5 0.02 0.035 0.014 0.036 0.038 0.011 0.846
Iraq-Baghdad 11862 2 0.059 0.033 0.013 0.011 0.062 0.262 0.561
Iraq-Baghdad 11865 5 0.007 0.07 0.008 0.08 0.067 0.147 0.62
Iraq-Baghdad 11868 2 0.005 0.008 0.008 0.006 0.009 0.006 0.958
Iraq-Baghdad 11869 2 0.116 0.024 0.007 0.009 0.228 0.018 0.598
Iraq-Baghdad 11870 0 0.031 0.146 0.004 0.025 0.039 0.077 0.679
Iraq-Baghdad 11871 5 0.006 0.361 0.015 0.031 0.067 0.008 0.513
Iraq-Baghdad 11872 2 0.016 0.169 0.014 0.007 0.082 0.004 0.707
Iraq-Baghdad 11873 7 0.005 0.369 0.016 0.01 0.045 0.028 0.526
Iraq-Baghdad 11874 2 0.01 0.029 0.008 0.007 0.053 0.048 0.847
Iraq-Baghdad 11875 15 0.008 0.007 0.062 0.124 0.016 0.175 0.608
Iraq-Baghdad 11876 21 0.009 0.06 0.038 0.033 0.035 0.018 0.808
Iraq-Baghdad 11877 7 0.008 0.048 0.054 0.006 0.017 0.047 0.82
Iraq-Baghdad 11878 7 0.027 0.064 0.005 0.015 0.373 0.009 0.508
Iraq-Baghdad 11879 2 0.007 0.022 0.012 0.187 0.018 0.015 0.74
Iraq-Baghdad 11880 10 0.008 0.043 0.015 0.01 0.03 0.007 0.886
Iraq-Baghdad 11881 0 0.046 0.071 0.011 0.016 0.158 0.079 0.62
Iraq-Baghdad 11882 15 0.012 0.075 0.007 0.012 0.067 0.013 0.815
Iraq-Baghdad 11883 0 0.041 0.006 0.011 0.008 0.327 0.008 0.598
Iraq-Baghdad 11884 0 0.004 0.004 0.006 0.009 0.005 0.01 0.962
Iraq-Baghdad 11885 0 0.003 0.017 0.004 0.012 0.012 0.008 0.943
Iraq-Baghdad 11886 0 0.008 0.131 0.01 0.041 0.126 0.075 0.609
Iraq-Baghdad 11887 13 0.012 0.092 0.027 0.021 0.014 0.035 0.799
Iran 9419 2 0.091 0.034 0.009 0.008 0.046 0.032 0.779
Iran 9420 2 0.005 0.013 0.01 0.013 0.008 0.094 0.855
Iran 9421 5 0.01 0.013 0.005 0.005 0.012 0.01 0.945
Iran 9422 5 0.013 0.065 0.005 0.01 0.054 0.11 0.742
Iran 9424 7 0.004 0.005 0.002 0.013 0.004 0.092 0.88
Iran 9425 7 0.002 0.004 0.005 0.006 0.004 0.011 0.968
Iran 9426 2 0.009 0.006 0.041 0.004 0.005 0.008 0.927
Iran 9427 2 0.008 0.006 0.012 0.005 0.008 0.004 0.958
Iran 9428 5 0.006 0.006 0.003 0.007 0.005 0.007 0.967
Iran 9429 15 0.012 0.025 0.05 0.022 0.015 0.065 0.811
Iran 9430 7 0.012 0.009 0.01 0.027 0.064 0.034 0.843
Iran 9431 7 0.012 0.062 0.013 0.106 0.017 0.053 0.738
Iran 9432 13 0.004 0.004 0.048 0.01 0.005 0.005 0.924
Iran 9433 5 0.007 0.007 0.006 0.01 0.011 0.025 0.933
Iran 9434 7 0.033 0.01 0.006 0.096 0.014 0.084 0.757
Iran 9435 5 0.007 0.006 0.017 0.028 0.005 0.011 0.925
Iran 9436 2 0.006 0.007 0.005 0.006 0.013 0.006 0.958
Iran 9437 2 0.007 0.009 0.008 0.011 0.012 0.006 0.948
Iran 9438 2 0.005 0.004 0.011 0.013 0.004 0.01 0.953 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Iran 9439 5 0.02 0.023 0.016 0.034 0.049 0.115 0.744
Iran 9440 2 0.003 0.009 0.014 0.006 0.008 0.003 0.958
Iran 9441 7 0.003 0.004 0.009 0.005 0.004 0.004 0.971
Iran 9442 5 0.019 0.013 0.067 0.033 0.012 0.009 0.846
Iran 9443 10 0.009 0.006 0.008 0.01 0.008 0.009 0.951
Iran 9444 5 0.002 0.003 0.002 0.003 0.004 0.004 0.981
Iran 9445 5 0.002 0.002 0.003 0.004 0.002 0.003 0.983
Iran 9446 10 0.004 0.004 0.007 0.007 0.003 0.009 0.965
Iran 9447 7 0.007 0.005 0.011 0.006 0.003 0.005 0.963
Iran 9448 13 0.003 0.003 0.005 0.005 0.004 0.003 0.977
Iran 9449 5 0.003 0.003 0.002 0.003 0.003 0.002 0.985
Iran 9450 7 0.004 0.012 0.005 0.005 0.007 0.017 0.95
Iran 9451 10 0.005 0.008 0.004 0.02 0.009 0.061 0.893
Iran 9452 2 0.006 0.005 0.005 0.023 0.006 0.006 0.949
Iran 9453 7 0.005 0.005 0.004 0.003 0.004 0.003 0.977
Iran 9454 7 0.003 0.005 0.003 0.004 0.004 0.003 0.979
Iran 9455 13 0.006 0.008 0.011 0.01 0.006 0.006 0.952
Iran 9456 2 0.011 0.009 0.006 0.018 0.012 0.013 0.932
Iran 9457 5 0.004 0.007 0.004 0.004 0.005 0.003 0.973
Iran 9458 2 0.004 0.007 0.006 0.009 0.006 0.01 0.958
Iran 9459 5 0.003 0.003 0.009 0.004 0.003 0.004 0.974
Iran 9460 10 0.016 0.01 0.047 0.008 0.012 0.009 0.899
Iran 9461 10 0.004 0.003 0.004 0.008 0.004 0.004 0.973
Iran 9462 10 0.012 0.006 0.014 0.017 0.007 0.006 0.938
Iran 9463 15 0.004 0.007 0.007 0.006 0.01 0.006 0.959
Iran 9464 7 0.003 0.005 0.004 0.005 0.004 0.008 0.972
Iran 9465 5 0.006 0.007 0.004 0.009 0.005 0.003 0.966
Iran 9466 13 0.01 0.017 0.048 0.008 0.013 0.004 0.901
Iran 9468 10 0.02 0.009 0.006 0.009 0.02 0.021 0.914
Iran 9469 10 0.02 0.021 0.02 0.035 0.017 0.024 0.863
Iran 9470 13 0.015 0.013 0.006 0.018 0.011 0.014 0.923
Iran 9471 7 0.007 0.005 0.004 0.007 0.009 0.004 0.964
Iran 9472 10 0.004 0.01 0.006 0.007 0.008 0.007 0.957
Iran 9473 5 0.004 0.004 0.008 0.006 0.005 0.007 0.967
Iran 9474 7 0.007 0.01 0.035 0.005 0.008 0.004 0.931
Iran 9475 7 0.006 0.008 0.008 0.005 0.01 0.003 0.96
Iran 9476 7 0.003 0.003 0.003 0.002 0.004 0.008 0.976
Iran 9477 7 0.009 0.006 0.003 0.009 0.008 0.043 0.922
Iran 9478 5 0.008 0.008 0.065 0.058 0.026 0.021 0.815
Iran 9479 7 0.002 0.003 0.003 0.004 0.003 0.009 0.977
Iran 9480 13 0.008 0.005 0.005 0.019 0.008 0.012 0.942
Iran 9481 10 0.005 0.015 0.01 0.004 0.006 0.006 0.954
Iran 9482 5 0.013 0.023 0.007 0.024 0.023 0.03 0.88
Iran 9483 13 0.009 0.008 0.006 0.056 0.015 0.175 0.732
Iran 9484 2 0.033 0.128 0.005 0.01 0.132 0.005 0.688
Iran 9485 10 0.004 0.007 0.008 0.011 0.01 0.081 0.877
Iran 9486 10 0.02 0.008 0.006 0.007 0.01 0.005 0.944
Iran 9487 5 0.004 0.006 0.013 0.015 0.006 0.008 0.948
Iran 9488 10 0.006 0.008 0.003 0.006 0.007 0.005 0.964
Iran 9489 15 0.005 0.007 0.035 0.022 0.008 0.006 0.916
Iran 9490 13 0.005 0.003 0.006 0.01 0.005 0.009 0.962
Iran 9491 7 0.003 0.003 0.004 0.003 0.004 0.005 0.979
Iran 9492 10 0.005 0.005 0.005 0.01 0.004 0.003 0.968
Iran 9493 2 0.005 0.006 0.005 0.008 0.004 0.015 0.956
Iran 9494 7 0.004 0.007 0.003 0.004 0.011 0.003 0.968
Iran 9495 5 0.004 0.003 0.013 0.006 0.004 0.005 0.964 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Iran 9497 10 0.004 0.004 0.056 0.004 0.004 0.004 0.924
Iran 9498 10 0.004 0.005 0.005 0.005 0.006 0.008 0.967
Iran 9499 5 0.005 0.007 0.011 0.012 0.007 0.071 0.888
Iran 9500 7 0.003 0.003 0.012 0.008 0.003 0.004 0.968
Iran 9501 2 0.036 0.027 0.034 0.031 0.023 0.006 0.842
Iran 9502 5 0.006 0.009 0.003 0.007 0.011 0.228 0.736
Iran 9503 7 0.003 0.003 0.007 0.009 0.003 0.005 0.971
Iran 9504 5 0.003 0.003 0.002 0.002 0.004 0.003 0.983
Iran 9505 5 0.002 0.002 0.002 0.002 0.002 0.005 0.985
Iran 9506 7 0.015 0.006 0.027 0.027 0.008 0.008 0.91
Iran 9507 31 0.01 0.038 0.039 0.015 0.011 0.036 0.852
Iran 9508 10 0.004 0.006 0.02 0.012 0.008 0.092 0.858
Iran 9509 18 0.006 0.005 0.005 0.008 0.01 0.031 0.934
Iran 9510 15 0.005 0.004 0.01 0.005 0.006 0.049 0.921
Iran 9511 13 0.014 0.005 0.005 0.004 0.007 0.005 0.96
Iran 9512 28 0.069 0.014 0.099 0.009 0.031 0.011 0.768
Iran 9513 21 0.008 0.006 0.012 0.007 0.019 0.005 0.943
Iran 9514 15 0.024 0.057 0.033 0.021 0.106 0.012 0.748
Iran 9515 13 0.167 0.007 0.018 0.016 0.007 0.006 0.78
Iran 9516 15 0.009 0.008 0.081 0.011 0.01 0.006 0.876
Iran 9517 13 0.027 0.012 0.009 0.053 0.028 0.056 0.814
Iran 9518 13 0.172 0.022 0.02 0.02 0.041 0.018 0.708
Iran 9519 18 0.05 0.01 0.009 0.011 0.016 0.005 0.9
Iran 9520 15 0.063 0.014 0.085 0.009 0.013 0.004 0.812
Iran 9521 21 0.009 0.009 0.132 0.02 0.008 0.006 0.816
Iran 9522 15 0.024 0.069 0.006 0.036 0.191 0.048 0.626
Iran 9523 13 0.021 0.081 0.025 0.008 0.043 0.008 0.814
Iran 9524 15 0.004 0.006 0.004 0.008 0.005 0.046 0.928
Iran 9526 15 0.004 0.006 0.006 0.01 0.006 0.091 0.877
Iran 9527 13 0.015 0.014 0.024 0.042 0.025 0.022 0.859
Iran 9528 15 0.004 0.003 0.004 0.005 0.003 0.005 0.977
Iran 9529 15 0.002 0.003 0.005 0.022 0.003 0.025 0.938
Iran 9530 10 0.006 0.006 0.006 0.007 0.006 0.032 0.936
Iran 9531 15 0.025 0.038 0.05 0.031 0.032 0.02 0.804
Iran 9532 5 0.004 0.004 0.004 0.005 0.006 0.004 0.973
Dubai 10104 2 0.009 0.053 0.676 0.017 0.021 0.003 0.222
Dubai 10105 2 0.011 0.007 0.762 0.021 0.01 0.074 0.115
Dubai 10106 18 0.009 0.011 0.661 0.19 0.064 0.01 0.057
Dubai 10107 5 0.044 0.026 0.293 0.075 0.033 0.155 0.375
Dubai 10108 2 0.008 0.02 0.309 0.574 0.02 0.044 0.026
Dubai 10109 18 0.013 0.008 0.424 0.022 0.015 0.102 0.415
Dubai 10110 7 0.015 0.006 0.821 0.006 0.009 0.011 0.132
Dubai 10111 13 0.004 0.015 0.791 0.141 0.02 0.009 0.02
Dubai 10112 7 0.021 0.019 0.521 0.077 0.283 0.053 0.027
Dubai 10120 15 0.01 0.009 0.759 0.073 0.017 0.011 0.12
Kenya-Nairobi 9833 13 0.551 0.011 0.027 0.123 0.059 0.029 0.2
Kenya-Nairobi 9834 0 0.732 0.015 0.019 0.202 0.011 0.014 0.007
Kenya-Nairobi 9835 0 0.449 0.088 0.241 0.025 0.012 0.18 0.006
Kenya-Nairobi 9836 2 0.724 0.008 0.027 0.19 0.009 0.029 0.013
Kenya-Nairobi 9837 0 0.762 0.048 0.014 0.032 0.011 0.078 0.055
Kenya-Nairobi 9838 2 0.559 0.048 0.087 0.01 0.078 0.016 0.202
Kenya-Nairobi 9839 0 0.173 0.028 0.388 0.341 0.02 0.038 0.012
Kenya-Nairobi 9840 0 0.475 0.207 0.013 0.175 0.108 0.008 0.014
Kenya-Nairobi 9841 2 0.821 0.021 0.078 0.05 0.011 0.011 0.008
Kenya-Nairobi 9842 2 0.686 0.03 0.113 0.019 0.022 0.091 0.04
Kenya-Nairobi 9843 0 0.833 0.013 0.051 0.07 0.012 0.013 0.009 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Kenya-Nairobi 9844 2 0.753 0.01 0.182 0.012 0.009 0.029 0.005
Kenya-Nairobi 9845 0 0.67 0.08 0.056 0.013 0.118 0.046 0.018
Kenya-Nairobi 9846 2 0.567 0.013 0.006 0.295 0.027 0.08 0.011
Kenya-Nairobi 9847 0 0.81 0.008 0.117 0.017 0.022 0.016 0.01
Kenya-Nairobi 9848 0 0.553 0.102 0.02 0.027 0.182 0.092 0.024
Kenya-Nairobi 9849 5 0.151 0.054 0.024 0.664 0.084 0.016 0.008
Kenya-Nairobi 9850 7 0.637 0.017 0.035 0.045 0.244 0.01 0.013
Kenya-Nairobi 9851 2 0.535 0.006 0.043 0.389 0.014 0.006 0.007
Kenya-Nairobi 9852 7 0.473 0.063 0.407 0.009 0.039 0.003 0.005
Kenya-Nairobi 9853 2 0.752 0.014 0.107 0.039 0.011 0.02 0.058
Kenya-Nairobi 9854 0 0.785 0.024 0.045 0.023 0.044 0.005 0.075
Kenya-Nairobi 9855 2 0.461 0.281 0.125 0.074 0.038 0.007 0.015
Kenya-Nairobi 9856 2 0.685 0.018 0.192 0.075 0.015 0.01 0.005
Kenya-Nairobi 9857 23 0.434 0.033 0.007 0.449 0.03 0.039 0.009
Kenya-Nairobi 9858 15 0.854 0.013 0.032 0.042 0.011 0.042 0.006
Kenya-Nairobi 9859 15 0.87 0.005 0.029 0.029 0.005 0.047 0.015
Kenya-Nairobi 9860 5 0.864 0.014 0.036 0.025 0.006 0.043 0.012
Kenya-Nairobi 9861 2 0.764 0.028 0.183 0.005 0.009 0.004 0.007
Kenya-Nairobi 9862 7 0.456 0.037 0.03 0.336 0.119 0.016 0.004
Kenya-Nairobi 9863 2 0.666 0.007 0.09 0.202 0.005 0.019 0.011
Kenya-Nairobi 9864 7 0.7 0.02 0.044 0.123 0.018 0.004 0.091
Kenya-Nairobi 9865 10 0.37 0.103 0.033 0.334 0.029 0.054 0.076
Kenya-Nairobi 9866 7 0.532 0.191 0.058 0.061 0.134 0.019 0.005
Kenya-Nairobi 9867 0 0.313 0.031 0.02 0.454 0.123 0.023 0.037
Kenya-Nairobi 9868 5 0.454 0.373 0.059 0.047 0.05 0.005 0.011
Kenya-Pate 2000 7 0.076 0.02 0.844 0.008 0.045 0.004 0.003
Kenya-Pate 2001 13 0.002 0.003 0.983 0.002 0.003 0.002 0.004
Kenya-Pate 2002 2 0.002 0.003 0.97 0.003 0.003 0.008 0.011
Kenya-Pate 2003 2 0.005 0.005 0.919 0.009 0.003 0.054 0.005
Kenya-Pate 2004 10 0.007 0.016 0.901 0.023 0.025 0.016 0.011
Kenya-Pate 2006 7 0.004 0.007 0.774 0.01 0.006 0.08 0.12
Kenya-Pate 2007 7 0.004 0.004 0.977 0.004 0.004 0.004 0.004
Kenya-Pate 2009 28 0.014 0.022 0.941 0.003 0.013 0.003 0.004
Kenya-Pate 2011 13 0.01 0.015 0.895 0.043 0.026 0.008 0.004
Kenya-Lamu 1848 10 0.01 0.004 0.865 0.034 0.01 0.068 0.009
Kenya-Lamu 2014 5 0.006 0.02 0.934 0.019 0.012 0.003 0.006
Kenya-Lamu 2015 7 0.01 0.051 0.655 0.006 0.261 0.01 0.007
Kenya-Lamu 2016 7 0.032 0.014 0.907 0.009 0.026 0.006 0.004
Kenya-Lamu 2018 2 0.029 0.067 0.863 0.005 0.027 0.004 0.004
Kenya-Lamu 2019 7 0.034 0.048 0.823 0.057 0.021 0.011 0.007
Kenya-Lamu 2021 7 0.008 0.006 0.936 0.011 0.006 0.005 0.028
Kenya-Lamu 2023 13 0.006 0.004 0.975 0.004 0.004 0.005 0.002
Kenya-Lamu 2024 2 0.003 0.003 0.984 0.003 0.003 0.002 0.003
Kenya-Lamu 2025 5 0.005 0.008 0.95 0.004 0.01 0.009 0.015
Kenya-Lamu 2026 18 0.003 0.007 0.963 0.006 0.012 0.005 0.004
Kenya-Lamu 2027 26 0.088 0.016 0.773 0.047 0.021 0.021 0.033
Kenya-Lamu 2029 5 0.003 0.003 0.984 0.003 0.003 0.003 0.003
Kenya-Lamu 2030 5 0.022 0.005 0.939 0.013 0.013 0.004 0.004
Kenya-Lamu 2031 18 0.045 0.02 0.896 0.007 0.015 0.008 0.009
Kenya-Lamu 2032 10 0.006 0.007 0.952 0.006 0.006 0.006 0.017
Kenya-Lamu 2033 13 0.011 0.028 0.908 0.017 0.018 0.007 0.011
Kenya-Lamu 3241 18 0.018 0.029 0.808 0.039 0.013 0.084 0.008
Kenya-Lamu 3246 7 0.034 0.131 0.682 0.011 0.119 0.014 0.008
Kenya-Lamu 3247 13 0.188 0.011 0.714 0.029 0.037 0.009 0.012
India-Udaipur 11835 10 0.024 0.075 0.112 0.159 0.137 0.268 0.225
India-Udaipur 11836 5 0.009 0.02 0.075 0.422 0.044 0.023 0.407 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 ndia-Udaipur 11837 5 0.005 0.02 0.053 0.551 0.009 0.021 0.341 ndia-Agra 11823 0 0.006 0.018 0.014 0.452 0.007 0.006 0.497 ndia-Agra 11824 0 0.005 0.016 0.108 0.585 0.016 0.007 0.263 ndia-Agra 11825 2 0.009 0.01 0.006 0.475 0.007 0.007 0.487 ndia-Agra 11826 7 0.004 0.005 0.003 0.536 0.004 0.004 0.444 ndia-Agra 11827 0 0.003 0.006 0.005 0.565 0.012 0.004 0.404 ndia-Agra 11828 5 0.006 0.024 0.034 0.517 0.044 0.01 0.365 ndia-Agra 11829 5 0.016 0.032 0.012 0.746 0.045 0.007 0.141 ndia-Agra 11830 5 0.003 0.007 0.005 0.593 0.012 0.005 0.376 ndia-Agra 11831 5 0.01 0.031 0.013 0.442 0.027 0.007 0.469 ndia-Agra 11832 0 0.004 0.009 0.015 0.416 0.007 0.006 0.544 ndia-Agra 11833 2 0.005 0.029 0.058 0.379 0.01 0.017 0.502 ndia-Agra 11834 5 0.004 0.005 0.004 0.518 0.004 0.004 0.462 ndia-Hyderbad 11802 7 0.032 0.463 0.016 0.353 0.086 0.038 0.012 ndia-Hyderbad 11803 7 0.007 0.066 0.031 0.708 0.133 0.008 0.047 ndia-Hyderbad 11804 10 0.007 0.008 0.213 0.23 0.011 0.464 0.067 ndia-Hyderbad 11805 5 0.021 0.017 0.037 0.858 0.019 0.033 0.015 ndia-Hyderbad 11807 2 0.004 0.013 0.014 0.91 0.007 0.009 0.042 ndia-Hyderbad 11808 2 0.011 0.008 0.012 0.88 0.009 0.075 0.004 ndia-Hyderbad 11809 2 0.111 0.065 0.007 0.655 0.085 0.003 0.073 ndia-Hyderbad 11810 0 0.015 0.134 0.024 0.766 0.026 0.021 0.014 ndia-Hyderbad 11811 0 0.005 0.008 0.435 0.516 0.013 0.012 0.011 ndia-Hyderbad 11812 13 0.004 0.009 0.012 0.663 0.013 0.041 0.259 ndia-Hyderbad 11813 10 0.006 0.01 0.007 0.712 0.063 0.122 0.08 ndia-Hyderbad 11814 0 0.007 0.013 0.041 0.904 0.008 0.012 0.014 ndia-Hyderbad 11815 0 0.007 0.011 0.153 0.756 0.006 0.019 0.049 ndia-Hyderbad 11816 0 0.005 0.031 0.011 0.917 0.015 0.004 0.017 ndia-Hyderbad 11817 5 0.006 0.009 0.013 0.947 0.006 0.009 0.01 ndia-Hyderbad 11818 2 0.004 0.005 0.023 0.916 0.007 0.022 0.025 ndia-Hyderbad 11819 0 0.006 0.035 0.01 0.913 0.016 0.004 0.017 ndia-Hyderbad 11820 5 0.006 0.011 0.137 0.724 0.006 0.087 0.03 ndia-Hyderbad 11821 0 0.017 0.125 0.046 0.748 0.019 0.028 0.018 ndia-Hyderbad 11822 0 0.008 0.015 0.071 0.75 0.077 0.068 0.01 ndia-Andhra 10159 5 0.01 0.015 0.006 0.92 0.008 0.038 0.004 ndia-Andhra 10160 2 0.009 0.012 0.068 0.635 0.005 0.259 0.013 ndia-Andhra 10161 0 0.008 0.005 0.006 0.959 0.006 0.006 0.009 ndia-Andhra 10162 5 0.006 0.006 0.01 0.953 0.008 0.007 0.009 ndia-Andhra 10163 0 0.005 0.007 0.104 0.784 0.01 0.075 0.015 ndia-Andhra 10164 2 0.004 0.006 0.01 0.712 0.009 0.174 0.086 ndia-Andhra 10165 0 0.008 0.015 0.114 0.821 0.008 0.009 0.025 ndia-Andhra 10166 5 0.023 0.017 0.33 0.577 0.032 0.015 0.006 ndia-Andhra 10167 2 0.029 0.197 0.064 0.597 0.085 0.022 0.006 ndia-Andhra 10168 2 0.005 0.021 0.006 0.907 0.015 0.016 0.03 ndia-Andhra 10169 5 0.017 0.024 0.007 0.91 0.01 0.027 0.004 ndia-Andhra 10170 0 0.02 0.031 0.017 0.824 0.031 0.068 0.008 ndia-Andhra 10171 2 0.004 0.006 0.01 0.713 0.009 0.173 0.085 ndia-Andhra 10172 5 0.072 0.02 0.007 0.808 0.015 0.034 0.045 ndia-Andhra 10173 5 0.004 0.013 0.015 0.946 0.007 0.012 0.003 ndia-Andhra 10174 5 0.01 0.013 0.003 0.957 0.009 0.006 0.002 ndia-Andhra 10175 5 0.087 0.015 0.012 0.851 0.012 0.009 0.014 ndia-Andhra 10176 0 0.009 0.013 0.013 0.713 0.021 0.191 0.04 ndia-Andhra 10177 0 0.01 0.015 0.01 0.863 0.019 0.072 0.011 ndia-Andhra 10178 5 0.008 0.006 0.007 0.942 0.009 0.01 0.018 ndia-Andhra 10179 2 0.045 0.031 0.021 0.882 0.008 0.007 0.005 ndia-Andhra 10180 2 0.024 0.074 0.005 0.758 0.124 0.005 0.01 ndia-Andhra 10181 7 0.009 0.015 0.013 0.767 0.011 0.18 0.005 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
India-Kolkata 10113 7 0.014 0.019 0.075 0.833 0.025 0.019 0.014
India-Kolkata 10114 2 0.006 0.015 0.014 0.933 0.01 0.01 0.013
India-Kolkata 10115 0 0.029 0.115 0.024 0.769 0.037 0.018 0.008
India-Kolkata 10116 7 0.007 0.012 0.023 0.926 0.01 0.014 0.008
India-Kolkata 10117 5 0.011 0.045 0.262 0.138 0.045 0.48 0.019
India-Kolkata 10118 13 0.011 0.162 0.043 0.652 0.012 0.018 0.101
India-Kolkata 10119 7 0.021 0.028 0.013 0.834 0.088 0.005 0.012
Sri Lanka 8780 0 0.048 0.027 0.016 0.796 0.072 0.026 0.014
Sri Lanka 8781 5 0.046 0.043 0.011 0.796 0.083 0.009 0.012
Sri Lanka 8782 15 0.094 0.096 0.026 0.702 0.044 0.016 0.022
Sri Lanka 8783 0 0.031 0.051 0.06 0.718 0.078 0.016 0.046
Sri Lanka 8784 5 0.02 0.01 0.036 0.852 0.02 0.043 0.02
Sri Lanka 8785 7 0.077 0.09 0.024 0.545 0.064 0.015 0.185
Sri Lanka 8786 0 0.066 0.096 0.017 0.52 0.236 0.013 0.052
Sri Lanka 8787 0 0.242 0.025 0.009 0.68 0.017 0.005 0.022
Sri Lanka 8788 5 0.03 0.012 0.005 0.776 0.024 0.006 0.146
Sri Lanka 8789 2 0.419 0.025 0.007 0.429 0.089 0.006 0.024
Sri Lanka 8790 0 0.123 0.03 0.004 0.806 0.026 0.006 0.005
Sri Lanka 8791 5 0.007 0.01 0.07 0.811 0.011 0.009 0.082
Sri Lanka 8792 2 0.105 0.016 0.01 0.824 0.034 0.004 0.007
Sri Lanka 8793 5 0.211 0.01 0.015 0.693 0.054 0.003 0.013
Sri Lanka 8794 5 0.124 0.043 0.005 0.744 0.064 0.008 0.012
Sri Lanka 8795 0 0.021 0.092 0.032 0.807 0.025 0.016 0.007
Sri Lanka 8796 7 0.06 0.092 0.013 0.76 0.05 0.02 0.005
Sri Lanka 8797 2 0.416 0.009 0.018 0.381 0.042 0.037 0.097
Sri Lanka 8798 2 0.033 0.029 0.006 0.787 0.098 0.014 0.034
Sri Lanka 8799 7 0.183 0.006 0.117 0.666 0.007 0.003 0.018
Sri Lanka 8800 10 0.314 0.034 0.05 0.318 0.035 0.226 0.023
Sri Lanka 8801 10 0.125 0.03 0.334 0.278 0.019 0.008 0.205
Sri Lanka 8802 2 0.527 0.004 0.009 0.425 0.007 0.004 0.024
Sri Lanka 8803 15 0.044 0.023 0.174 0.671 0.066 0.011 0.012
Thailand 11688 7 0.003 0.003 0.003 0.976 0.003 0.009 0.003
Thailand 11689 15 0.004 0.005 0.003 0.964 0.004 0.009 0.011
Thailand 11691 55 0.012 0.01 0.01 0.71 0.013 0.232 0.013
Thailand 11698 23 0.015 0.008 0.006 0.641 0.01 0.315 0.005
Thailand 11702 10 0.009 0.004 0.006 0.965 0.005 0.009 0.003
Thailand 11703 13 0.004 0.003 0.003 0.971 0.003 0.013 0.004
Thailand 11705 21 0.003 0.005 0.004 0.969 0.009 0.006 0.003
Thailand 11707 10 0.004 0.004 0.005 0.966 0.005 0.013 0.003
Thailand 11708 2 0.008 0.025 0.025 0.893 0.013 0.029 0.006
Thailand 11709 15 0.005 0.005 0.004 0.968 0.005 0.009 0.003
Thailand 11710 15 0.006 0.006 0.004 0.957 0.005 0.018 0.004
Thailand 11711 2 0.004 0.003 0.007 0.925 0.003 0.054 0.004
Thailand 11714 13 0.01 0.005 0.021 0.931 0.012 0.016 0.005
Thailand 11715 21 0.007 0.004 0.004 0.95 0.005 0.023 0.007
Thailand 11717 13 0.006 0.006 0.003 0.966 0.005 0.008 0.005
Thailand 11718 7 0.022 0.018 0.012 0.895 0.011 0.036 0.006
Thailand 11720 7 0.003 0.003 0.002 0.967 0.006 0.016 0.003
Vietnam 8844 5 0.004 0.005 0.007 0.959 0.005 0.015 0.005
Vietnam 8845 13 0.005 0.006 0.01 0.961 0.005 0.006 0.007
Vietnam 8846 13 0.083 0.024 0.027 0.791 0.033 0.038 0.005
Vietnam 8847 15 0.182 0.006 0.005 0.765 0.013 0.016 0.013
Vietnam 8848 10 0.096 0.013 0.01 0.858 0.013 0.005 0.005
Vietnam 8849 2 0.009 0.013 0.006 0.937 0.018 0.013 0.004
Vietnam 8850 5 0.423 0.013 0.011 0.378 0.026 0.144 0.005
Vietnam 8851 10 0.009 0.009 0.004 0.95 0.008 0.009 0.011 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Vietnam 8852 13 0.074 0.011 0.015 0.561 0.269 0.064 0.007
Vietnam 8853 10 0.021 0.028 0.005 0.591 0.341 0.008 0.006
Vietnam 8854 7 0.209 0.007 0.004 0.6 0.069 0.055 0.055
Vietnam 8855 10 0.004 0.005 0.004 0.905 0.005 0.072 0.005
Vietnam 8856 10 0.006 0.03 0.003 0.869 0.083 0.005 0.003
Vietnam 8857 7 0.023 0.011 0.011 0.908 0.014 0.006 0.028
Vietnam 8858 13 0.006 0.006 0.004 0.915 0.005 0.061 0.003
Vietnam 8859 13 0.015 0.006 0.008 0.728 0.013 0.22 0.01
Vietnam 8860 10 0.195 0.132 0.031 0.409 0.164 0.059 0.009
Vietnam 8861 10 0.08 0.016 0.016 0.711 0.137 0.021 0.02
Vietnam 8862 7 0.011 0.015 0.046 0.844 0.009 0.072 0.004
Vietnam 8863 15 0.022 0.02 0.011 0.831 0.017 0.092 0.007
Taiwan 8681 7 0.737 0.01 0.008 0.009 0.011 0.21 0.015
Taiwan 8682 2 0.004 0.004 0.006 0.243 0.006 0.72 0.017
Taiwan 8683 7 0.077 0.012 0.012 0.069 0.019 0.8 0.011
Taiwan 8684 7 0.735 0.03 0.008 0.035 0.011 0.17 0.011
Taiwan 8685 2 0.094 0.006 0.006 0.283 0.013 0.595 0.003
Taiwan 8686 7 0.332 0.008 0.012 0.029 0.044 0.567 0.008
Taiwan 8687 2 0.056 0.024 0.034 0.349 0.094 0.406 0.038
Taiwan 8688 47 0.021 0.023 0.035 0.199 0.012 0.702 0.008
Taiwan 8689 5 0.098 0.014 0.165 0.047 0.051 0.596 0.029
Taiwan 8690 7 0.015 0.006 0.007 0.421 0.017 0.495 0.039
Taiwan 8691 26 0.018 0.032 0.02 0.579 0.025 0.319 0.007
Taiwan 8692 5 0.011 0.007 0.011 0.118 0.007 0.841 0.005
Taiwan 8693 7 0.027 0.012 0.006 0.046 0.022 0.881 0.006
Taiwan 8694 5 0.379 0.006 0.003 0.564 0.005 0.041 0.003
Taiwan 8695 2 0.025 0.089 0.043 0.014 0.012 0.812 0.005
Taiwan 8696 23 0.929 0.012 0.006 0.014 0.009 0.027 0.004
Taiwan 8697 5 0.914 0.011 0.005 0.004 0.052 0.006 0.008
Taiwan 8698 7 0.972 0.006 0.004 0.004 0.006 0.004 0.003
Taiwan 8699 10 0.18 0.029 0.007 0.213 0.114 0.384 0.073
Taiwan 8700 7 0.051 0.055 0.006 0.425 0.049 0.399 0.015
Taiwan 8701 2 0.166 0.018 0.004 0.173 0.019 0.611 0.01
Taiwan 8702 5 0.058 0.273 0.02 0.029 0.039 0.568 0.013
Taiwan 8703 7 0.95 0.018 0.003 0.006 0.013 0.007 0.003
Taiwan 8704 2 0.02 0.008 0.027 0.058 0.145 0.731 0.011
Taiwan 8705 5 0.013 0.022 0.019 0.332 0.013 0.585 0.016
Taiwan 8706 7 0.011 0.013 0.023 0.088 0.014 0.844 0.008
Taiwan 8707 7 0.029 0.016 0.004 0.125 0.004 0.784 0.037
Taiwan 8708 15 0.952 0.006 0.007 0.009 0.008 0.015 0.004
Taiwan 8709 13 0.034 0.024 0.013 0.118 0.119 0.669 0.024
Japan-Oita 11967 5 0.015 0.015 0.011 0.038 0.017 0.894 0.009
Japan-Oita 11968 7 0.017 0.024 0.011 0.644 0.023 0.274 0.007
Japan-Oita 11969 7 0.034 0.02 0.01 0.027 0.014 0.888 0.007
Japan-Oita 11970 7 0.024 0.03 0.013 0.209 0.035 0.663 0.027
Japan-Oita 11971 7 0.043 0.004 0.024 0.041 0.009 0.871 0.007
Japan-Oita 11972 5 0.007 0.004 0.008 0.015 0.005 0.957 0.004
Japan-Oita 11973 7 0.037 0.016 0.092 0.025 0.012 0.797 0.021
Japan-Oita 11974 21 0.02 0.017 0.021 0.156 0.021 0.757 0.008
Japan-Oita 11975 10 0.027 0.01 0.007 0.376 0.017 0.559 0.003
Japan-Oita 11976 13 0.324 0.014 0.004 0.031 0.022 0.597 0.007
Japan-Oita 11977 7 0.342 0.008 0.005 0.028 0.045 0.568 0.004
Japan-Oita 11979 10 0.009 0.015 0.036 0.023 0.017 0.894 0.007
Japan-Oita 11980 7 0.021 0.007 0.017 0.022 0.011 0.916 0.007
Japan-Oita 11981 7 0.003 0.003 0.01 0.021 0.003 0.955 0.004
Japan-Oita 11982 13 0.061 0.006 0.007 0.173 0.028 0.721 0.004 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
Japan-Oita 11985 10 0.005 0.018 0.007 0.295 0.015 0.656 0.004
Japan-Oita 11986 10 0.121 0.123 0.007 0.06 0.074 0.599 0.016
Japan-Kanazawa 11929 10 0.976 0.004 0.003 0.003 0.007 0.003 0.003
Japan-Kanazawa 11931 10 0.059 0.011 0.009 0.107 0.006 0.8 0.008
Japan-Kanazawa 11932 7 0.227 0.012 0.005 0.046 0.009 0.691 0.01
Japan-Kanazawa 11933 15 0.005 0.004 0.247 0.017 0.004 0.72 0.003
Japan-Kanazawa 11934 7 0.027 0.008 0.009 0.015 0.012 0.927 0.003
Japan-Kanazawa 11936 7 0.012 0.008 0.006 0.107 0.012 0.852 0.004
Japan-Kanazawa 11937 10 0.014 0.005 0.003 0.011 0.008 0.956 0.003
Japan-Kanazawa 11939 10 0.022 0.006 0.007 0.093 0.012 0.846 0.014
Japan-Kanazawa 11940 10 0.006 0.007 0.007 0.008 0.007 0.95 0.015
Japan-Kanazawa 11941 10 0.008 0.014 0.004 0.019 0.014 0.921 0.021
Japan-Kanazawa 11942 7 0.006 0.011 0.053 0.048 0.011 0.865 0.006
Japan-Kanazawa 11943 28 0.039 0.024 0.009 0.309 0.034 0.546 0.039
Japan-Kanazawa 11944 39 0.888 0.032 0.04 0.011 0.009 0.011 0.008
Japan-Kanazawa 11945 10 0.038 0.006 0.025 0.045 0.008 0.869 0.009
Japan-Kanazawa 11946 10 0.01 0.029 0.012 0.009 0.004 0.932 0.004
Japan-Ohmiya 11947 5 0.065 0.046 0.014 0.038 0.014 0.817 0.007
Japan-Ohmiya 11948 10 0.071 0.121 0.015 0.01 0.059 0.693 0.03
Japan-Ohmiya 11951 5 0.052 0.031 0.017 0.113 0.019 0.739 0.028
Japan-Ohmiya 11953 7 0.009 0.009 0.005 0.04 0.014 0.918 0.004
Japan-Ohmiya 11954 5 0.177 0.044 0.008 0.194 0.015 0.552 0.01
Japan-Ohmiya 11955 7 0.108 0.023 0.193 0.09 0.017 0.564 0.004
Japan-Ohmiya 11956 7 0.042 0.011 0.015 0.137 0.016 0.77 0.009
Japan-Ohmiya 11957 2 0.189 0.028 0.012 0.008 0.048 0.696 0.019
Japan-Ohmiya 11959 18 0.049 0.253 0.008 0.01 0.012 0.662 0.005
Japan-Ohmiya 11960 2 0.013 0.006 0.004 0.065 0.004 0.887 0.021
Japan-Ohmiya 11961 5 0.004 0.014 0.003 0.007 0.008 0.959 0.005
Japan-Ohmiya 11962 13 0.01 0.007 0.014 0.192 0.006 0.761 0.01
Japan-Ohmiya 11963 2 0.248 0.005 0.007 0.021 0.01 0.703 0.005
Japan-Ohmiya 11964 5 0.161 0.022 0.019 0.142 0.021 0.606 0.029
Japan-Ohmiya 11965 7 0.006 0.009 0.021 0.023 0.006 0.932 0.003
Japan-Ohmiya 11966 2 0.103 0.026 0.017 0.035 0.014 0.795 0.01
Japan-Sapporo 11907 2 0.016 0.015 0.011 0.026 0.015 0.908 0.008
Japan-Sapporo 11909 7 0.941 0.008 0.004 0.014 0.017 0.012 0.005
Japan-Sapporo 11911 5 0.329 0.005 0.006 0.011 0.107 0.531 0.011
Japan-Sapporo 11913 7 0.437 0.005 0.009 0.006 0.008 0.532 0.003
Japan-Sapporo 11914 13 0.254 0.004 0.004 0.014 0.008 0.711 0.004
Japan-Sapporo 11915 10 0.017 0.028 0.011 0.625 0.011 0.294 0.013
Japan-Sapporo 11916 5 0.738 0.051 0.005 0.06 0.122 0.02 0.003
Japan-Sapporo 11917 5 0.838 0.04 0.036 0.007 0.034 0.035 0.009
Japan-Sapporo 11918 7 0.343 0.025 0.019 0.056 0.02 0.522 0.014
Japan-Sapporo 11921 7 0.006 0.006 0.016 0.05 0.007 0.907 0.008
Japan-Sapporo 11922 5 0.042 0.006 0.004 0.029 0.013 0.904 0.003
Japan-Sapporo 11923 7 0.192 0.009 0.015 0.086 0.037 0.655 0.006
Japan-Sapporo 11924 5 0.505 0.006 0.014 0.371 0.041 0.056 0.008
Japan-Sapporo 11925 7 0.005 0.006 0.01 0.086 0.005 0.883 0.004
Japan-Sapporo 11926 5 0.391 0.059 0.005 0.014 0.011 0.515 0.005
China-Henan 8869 2 0.047 0.076 0.003 0.009 0.028 0.828 0.009
China-Henan 8870 5 0.003 0.002 0.002 0.006 0.003 0.978 0.006
China-Henan 8871 5 0.006 0.017 0.019 0.005 0.008 0.843 0.103
China-Henan 8872 2 0.006 0.005 0.008 0.011 0.004 0.953 0.014
China-Henan 8873 5 0.009 0.008 0.005 0.006 0.018 0.948 0.007
China-Henan 8874 5 0.004 0.013 0.012 0.018 0.007 0.913 0.033
China-Henan 8875 5 0.003 0.003 0.003 0.002 0.002 0.985 0.002
China-Henan 8876 5 0.003 0.002 0.004 0.003 0.002 0.983 0.002 Table 24 - Population clustering of each random bred individual in the database by
STRs at K = 7
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7
China-Henan 8877 7 0.005 0.017 0.021 0.03 0.007 0.903 0.018
China-Henan 8878 5 0.003 0.007 0.003 0.003 0.006 0.976 0.002
China-Henan 8879 2 0.003 0.004 0.005 0.018 0.004 0.955 0.012
China-Henan 8880 7 0.006 0.005 0.014 0.004 0.004 0.954 0.013
China-Henan 8881 5 0.003 0.039 0.005 0.006 0.026 0.885 0.036
China-Henan 8882 5 0.022 0.016 0.019 0.04 0.02 0.874 0.009
China-Henan 8883 2 0.003 0.005 0.004 0.005 0.006 0.971 0.005
China-Henan 8884 2 0.002 0.011 0.036 0.021 0.004 0.907 0.02
China-Henan 8885 2 0.005 0.005 0.009 0.004 0.005 0.968 0.003
China-Henan 8886 2 0.003 0.009 0.005 0.004 0.006 0.967 0.006
China-Henan 8887 2 0.016 0.016 0.014 0.004 0.017 0.876 0.057
China-Henan 8888 2 0.01 0.012 0.003 0.014 0.008 0.933 0.02
South Korea 2769 5 0.004 0.003 0.002 0.005 0.004 0.979 0.003
South Korea 2772 47 0.004 0.005 0.011 0.012 0.005 0.955 0.007
South Korea 2775 13 0.007 0.006 0.006 0.005 0.013 0.959 0.005
South Korea 2776 13 0.026 0.015 0.014 0.047 0.071 0.824 0.004
South Korea 2779 2 0.004 0.004 0.007 0.016 0.005 0.957 0.007
South Korea 2784 2 0.003 0.003 0.002 0.007 0.003 0.978 0.004
South Korea 2785 2 0.011 0.011 0.005 0.009 0.015 0.865 0.084
South Korea 2786 2 0.007 0.004 0.002 0.005 0.005 0.975 0.002
South Korea 7671 2 0.007 0.007 0.004 0.008 0.011 0.96 0.004
South Korea 7672 2 0.007 0.006 0.019 0.008 0.006 0.952 0.004
South Korea 7673 2 0.006 0.01 0.003 0.003 0.027 0.93 0.019
South Korea 7674 2 0.021 0.007 0.006 0.008 0.079 0.874 0.006
South Korea 7675 10 0.008 0.007 0.003 0.006 0.012 0.961 0.003
South Korea 7676 7 0.009 0.007 0.013 0.008 0.009 0.941 0.013
South Korea 7677 15 0.232 0.023 0.006 0.006 0.084 0.365 0.284
South Korea 7678 2 0.014 0.008 0.005 0.005 0.009 0.952 0.008
South Korea 7679 5 0.004 0.006 0.004 0.004 0.005 0.973 0.005
South Korea 7680 7 0.019 0.014 0.011 0.005 0.021 0.925 0.005
South Korea 7681 13 0.013 0.154 0.003 0.007 0.053 0.758 0.013
South Korea 7682 5 0.006 0.016 0.005 0.008 0.011 0.951 0.003
South Korea 7683 7 0.003 0.003 0.004 0.008 0.004 0.974 0.004
South Korea 7684 7 0.029 0.177 0.009 0.048 0.157 0.57 0.009
South Korea 7685 18 0.014 0.008 0.006 0.022 0.008 0.937 0.005
South Korea 7686 10 0.027 0.01 0.004 0.007 0.013 0.934 0.005
South Korea 7687 10 0.062 0.049 0.056 0.125 0.01 0.695 0.004
South Korea 7688 2 0.501 0.03 0.025 0.055 0.03 0.356 0.004
South Korea 7689 10 0.007 0.006 0.006 0.006 0.007 0.963 0.005
South Korea 7690 10 0.006 0.01 0.011 0.025 0.008 0.938 0.003
South Korea 7691 7 0.008 0.008 0.016 0.008 0.015 0.938 0.007
South Korea 7692 5 0.008 0.015 0.01 0.058 0.026 0.87 0.012
South Korea 7693 2 0.052 0.047 0.03 0.021 0.106 0.734 0.011
South Korea 7694 5 0.003 0.003 0.003 0.005 0.003 0.98 0.002
South Korea 7695 7 0.039 0.04 0.063 0.004 0.075 0.774 0.006
South Korea 7696 5 0.004 0.003 0.003 0.004 0.006 0.972 0.007
South Korea 7697 10 0.007 0.005 0.005 0.012 0.008 0.949 0.014
South Korea 7698 23 0.027 0.042 0.017 0.213 0.055 0.612 0.034
South Korea 7699 7 0.005 0.01 0.004 0.014 0.014 0.941 0.011
South Korea 7700 7 0.007 0.013 0.005 0.061 0.028 0.865 0.02 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
USA-NY 2547 1 0.086 0.006 0.006 0.775 0.077 0.037 0.004 0.009
USA-NY 2559 3 0.009 0.002 0.008 0.618 0.006 0.348 0.004 0.004
USA-NY 2568 0 0.003 0.002 0.003 0.98 0.003 0.003 0.003 0.003
USA-NY 2569 5 0.015 0.008 0.004 0.942 0.009 0.005 0.011 0.005
USA-NY 2572 1 0.009 0.005 0.007 0.931 0.02 0.016 0.005 0.009
USA-NY 2578 17 0.041 0.008 0.003 0.883 0.048 0.009 0.003 0.005
USA-NY 2590 1 0.013 0.002 0.008 0.942 0.007 0.022 0.003 0.004
USA-NY 2591 2 0.015 0.009 0.004 0.944 0.004 0.007 0.007 0.011
USA-NY 2597 4 0.023 0.028 0.03 0.863 0.035 0.01 0.005 0.006
USA-MS 9971 3 0.009 0.007 0.058 0.885 0.024 0.007 0.005 0.006
USA-MS 9972 2 0.058 0.017 0.019 0.787 0.087 0.014 0.003 0.014
USA-MS 9974 2 0.01 0.005 0.119 0.823 0.022 0.011 0.003 0.007
USA-MS 9977 5 0.013 0.005 0.013 0.946 0.006 0.006 0.008 0.002
USA-MS 9980 2 0.01 0.01 0.011 0.904 0.013 0.028 0.004 0.019
USA-MS 9983 2 0.006 0.008 0.011 0.942 0.007 0.009 0.003 0.013
USA-MS 9985 3 0.009 0.002 0.228 0.719 0.005 0.028 0.005 0.004
USA-MS 9987 3 0.055 0.006 0.081 0.778 0.02 0.043 0.008 0.008
USA-MS 9989 2 0.015 0.003 0.03 0.914 0.019 0.007 0.008 0.003
USA-MS 9992 3 0.068 0.009 0.062 0.785 0.008 0.06 0.003 0.006
USA-HI 5366 3 0.023 0.003 0.018 0.712 0.021 0.019 0.176 0.028
USA-HI 5367 1 0.089 0.016 0.057 0.735 0.057 0.007 0.01 0.029
USA-HI 5371 1 0.026 0.015 0.018 0.696 0.047 0.185 0.01 0.004
USA-HI 5372 2 0.065 0.008 0.013 0.625 0.253 0.025 0.005 0.006
USA-HI 5379 1 0.067 0.016 0.016 0.84 0.01 0.023 0.026 0.004
USA-HI 5380 1 0.018 0.002 0.002 0.954 0.002 0.009 0.009 0.004
USA-HI 5383 3 0.028 0.199 0.011 0.401 0.015 0.147 0.017 0.182
USA-HI 5384 5 0.025 0.005 0.002 0.847 0.004 0.098 0.003 0.015
USA-HI 5401 2 0.039 0.004 0.02 0.848 0.007 0.026 0.024 0.033
USA-HI 5402 2 0.017 0.021 0.045 0.809 0.016 0.024 0.063 0.005
Brazil 7961 1 0.017 0.003 0.002 0.949 0.003 0.013 0.009 0.003
Brazil 7962 2 0.009 0.002 0.007 0.816 0.008 0.149 0.003 0.005
Brazil 7963 17 0.008 0.002 0.336 0.625 0.008 0.01 0.003 0.009
Brazil 7964 2 0.006 0.004 0.004 0.95 0.004 0.015 0.009 0.009
Brazil 7965 27 0.005 0.003 0.008 0.968 0.003 0.004 0.003 0.006
Brazil 7966 2 0.02 0.011 0.007 0.93 0.014 0.013 0.002 0.003
Brazil 7968 23 0.012 0.006 0.007 0.935 0.007 0.013 0.014 0.005
Brazil 7969 1 0.004 0.002 0.004 0.978 0.003 0.004 0.002 0.002
Brazil 7970 1 0.004 0.002 0.008 0.969 0.003 0.005 0.003 0.006
Brazil 7971 1 0.006 0.004 0.004 0.972 0.003 0.004 0.005 0.003
Brazil 7972 1 0.012 0.004 0.001 0.965 0.003 0.007 0.004 0.005
Brazil 7973 0 0.014 0.003 0.004 0.956 0.004 0.006 0.01 0.004
Brazil 7974 3 0.012 0.004 0.007 0.946 0.006 0.016 0.004 0.004
Brazil 7975 5 0.01 0.003 0.004 0.946 0.011 0.007 0.015 0.004
Brazil 7976 1 0.004 0.003 0.004 0.973 0.003 0.005 0.006 0.003
Brazil 7977 2 0.008 0.002 0.001 0.956 0.002 0.018 0.009 0.003
Brazil 7978 1 0.009 0.003 0.005 0.876 0.006 0.007 0.009 0.084
Brazil 7979 2 0.014 0.004 0.011 0.929 0.007 0.008 0.016 0.011
Brazil 7980 2 0.029 0.009 0.002 0.643 0.015 0.268 0.022 0.01
Brazil 7981 2 0.004 0.002 0.005 0.766 0.003 0.006 0.209 0.005
Brazil 7982 20 0.017 0.006 0.011 0.755 0.14 0.01 0.042 0.019
Brazil 7983 4 0.04 0.007 0.108 0.713 0.094 0.025 0.004 0.007
Brazil 7984 15 0.017 0.005 0.277 0.606 0.011 0.035 0.042 0.006
Brazil 7985 5 0.015 0.003 0.007 0.922 0.012 0.015 0.01 0.015
Brazil 7986 3 0.007 0.004 0.104 0.813 0.008 0.048 0.012 0.005
Brazil 7987 2 0.028 0.003 0.08 0.835 0.025 0.021 0.003 0.005
Brazil 7988 0 0.014 0.006 0.092 0.807 0.035 0.023 0.01 0.012 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Brazil 7989 1 0.008 0.004 0.263 0.69 0.015 0.008 0.005 0.008
Brazil 7990 1 0.005 0.002 0.105 0.867 0.008 0.004 0.003 0.005
Finland 8077 11 0.047 0.008 0.002 0.928 0.003 0.006 0.003 0.004
Finland 8084 11 0.263 0.006 0.005 0.69 0.014 0.004 0.013 0.004
Finland 8086 5 0.061 0.006 0.003 0.881 0.008 0.033 0.004 0.004
Finland 8089 8 0.014 0.015 0.005 0.798 0.116 0.012 0.018 0.022
Finland 8093 16 0.175 0.004 0.002 0.749 0.004 0.058 0.004 0.005
Finland 8094 9 0.04 0.076 0.015 0.808 0.019 0.032 0.003 0.008
Finland 8096 7 0.046 0.01 0.002 0.927 0.002 0.007 0.002 0.004
Finland 8107 24 0.004 0.002 0.001 0.982 0.003 0.003 0.002 0.003
Finland 8110 10 0.064 0.006 0.004 0.859 0.047 0.013 0.003 0.004
Finland 8116 16 0.01 0.006 0.009 0.899 0.012 0.011 0.009 0.044
Finland 8120 21 0.03 0.004 0.003 0.929 0.003 0.015 0.012 0.004
Germany 8711 4 0.006 0.002 0.002 0.976 0.002 0.005 0.003 0.003
Germany 8712 3 0.008 0.015 0.003 0.951 0.011 0.003 0.004 0.005
Germany 8713 3 0.073 0.015 0.004 0.822 0.008 0.03 0.031 0.016
Germany 8714 2 0.061 0.024 0.007 0.878 0.009 0.013 0.004 0.004
Germany 8715 4 0.014 0.005 0.002 0.964 0.003 0.006 0.002 0.003
Germany 8716 3 0.008 0.004 0.003 0.968 0.005 0.006 0.004 0.003
Germany 8717 11 0.008 0.005 0.003 0.968 0.006 0.005 0.003 0.002
Germany 8720 3 0.009 0.004 0.61 0.348 0.017 0.007 0.003 0.003
Germany 8721 10 0.101 0.004 0.002 0.87 0.002 0.012 0.002 0.006
Germany 8727 1 0.021 0.004 0.002 0.931 0.007 0.024 0.004 0.007
Germany 8728 10 0.006 0.003 0.003 0.964 0.005 0.005 0.003 0.01
Germany 8729 2 0.005 0.002 0.002 0.983 0.002 0.003 0.002 0.002
Germany 8730 22 0.048 0.002 0.007 0.869 0.007 0.015 0.038 0.014
Germany 8731 12 0.007 0.002 0.002 0.974 0.003 0.005 0.004 0.004
Germany 8732 4 0.015 0.003 0.002 0.956 0.006 0.009 0.003 0.007
Germany 8733 16 0.018 0.01 0.041 0.855 0.004 0.007 0.005 0.06
Germany 8734 1 0.008 0.002 0.001 0.976 0.002 0.007 0.002 0.002
Germany 8735 2 0.022 0.003 0.007 0.952 0.005 0.005 0.004 0.002
Germany 8736 1 0.026 0.015 0.002 0.919 0.005 0.023 0.007 0.003
Germany 8737 3 0.037 0.011 0.005 0.916 0.006 0.007 0.005 0.014
Germany 8738 10 0.191 0.038 0.002 0.751 0.004 0.008 0.002 0.003
Germany 8739 2 0.012 0.002 0.002 0.967 0.002 0.008 0.002 0.005
Germany 8741 11 0.04 0.003 0.002 0.935 0.006 0.008 0.003 0.003
Germany 8742 9 0.022 0.003 0.006 0.956 0.004 0.004 0.004 0.002
Germany 8744 6 0.23 0.004 0.085 0.539 0.008 0.108 0.02 0.006
Germany 8745 23 0.084 0.005 0.002 0.888 0.004 0.01 0.003 0.006
Germany 8746 1 0.007 0.003 0.004 0.958 0.004 0.005 0.002 0.016
Germany 8747 13 0.004 0.002 0.003 0.978 0.004 0.004 0.003 0.003
Germany 8749 2 0.007 0.004 0.002 0.976 0.003 0.003 0.002 0.003
Italy-Milan 8050 1 0.353 0.055 0.02 0.483 0.016 0.01 0.058 0.005
Italy-Milan 8057 2 0.633 0.011 0.058 0.265 0.018 0.005 0.004 0.006
Italy-Milan 8060 1 0.353 0.011 0.046 0.551 0.009 0.015 0.003 0.012
Italy-Milan 8061 2 0.327 0.012 0.154 0.464 0.009 0.019 0.006 0.009
Italy-Milan 8062 3 0.644 0.004 0.005 0.273 0.007 0.056 0.004 0.006
Italy-Milan 8065 5 0.032 0.004 0.004 0.508 0.004 0.434 0.004 0.009
Italy-Milan 8066 1 0.349 0.007 0.082 0.529 0.018 0.006 0.003 0.005
Italy-Milan 8067 2 0.065 0.016 0.041 0.513 0.006 0.338 0.003 0.019
Italy-Milan 8068 2 0.543 0.004 0.007 0.353 0.007 0.075 0.004 0.009
Italy-Milan 8069 1 0.412 0.008 0.039 0.429 0.083 0.018 0.005 0.006
Italy-Milan 8071 3 0.045 0.006 0.006 0.894 0.007 0.016 0.01 0.016
Italy-Milan 8072 3 0.507 0.006 0.083 0.259 0.029 0.042 0.07 0.004
Italy-Milan 8073 1 0.124 0.015 0.01 0.66 0.013 0.169 0.006 0.003
Italy-Milan 8074 2 0.008 0.002 0.292 0.66 0.013 0.017 0.003 0.005 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Italy-Rome 8586 1 0.061 0.009 0.003 0.517 0.009 0.359 0.014 0.027
Italy-Rome 8589 3 0.088 0.003 0.005 0.788 0.015 0.072 0.025 0.005
Italy-Rome 8592 2 0.458 0.075 0.005 0.394 0.034 0.018 0.011 0.005
Italy-Rome 8594 1 0.241 0.017 0.016 0.679 0.011 0.024 0.006 0.007
Italy-Rome 8595 1 0.122 0.091 0.016 0.565 0.093 0.09 0.015 0.008
Italy-Rome 8596 1 0.161 0.006 0.007 0.459 0.009 0.345 0.008 0.005
Italy-Rome 8597 1 0.053 0.026 0.016 0.704 0.012 0.174 0.011 0.004
Italy-Rome 8599 1 0.024 0.004 0.015 0.854 0.009 0.061 0.029 0.003
Italy-Rome 8601 2 0.112 0.144 0.006 0.645 0.01 0.036 0.038 0.009
Italy-Rome 8602 3 0.237 0.006 0.006 0.635 0.036 0.071 0.005 0.004
Italy-Rome 8603 1 0.021 0.012 0.015 0.882 0.012 0.05 0.005 0.003
Italy-Rome 8604 3 0.142 0.007 0.003 0.547 0.004 0.025 0.263 0.008
Italy-Rome 8609 2 0.149 0.006 0.005 0.612 0.007 0.211 0.006 0.004
Italy-Rome 8610 2 0.235 0.005 0.005 0.59 0.007 0.139 0.01 0.01
Italy-Rome 8611 2 0.421 0.021 0.004 0.504 0.007 0.032 0.004 0.007
Turkey 6477 3 0.924 0.003 0.006 0.044 0.007 0.008 0.005 0.003
Turkey 6478 12 0.927 0.004 0.003 0.013 0.005 0.032 0.014 0.003
Turkey 6480 9 0.703 0.003 0.017 0.227 0.005 0.018 0.02 0.008
Turkey 6481 13 0.93 0.015 0.003 0.008 0.007 0.01 0.018 0.009
Turkey 6482 8 0.012 0.005 0.959 0.006 0.004 0.005 0.005 0.004
Turkey 6484 10 0.01 0.005 0.003 0.965 0.005 0.004 0.002 0.006
Turkey 6486 6 0.896 0.005 0.004 0.067 0.006 0.01 0.006 0.007
Turkey 6487 13 0.906 0.002 0.003 0.052 0.005 0.026 0.003 0.003
Turkey 6488 11 0.748 0.005 0.003 0.203 0.006 0.015 0.014 0.007
Turkey 6491 6 0.781 0.014 0.002 0.039 0.003 0.157 0.003 0.002
Turkey 6494 12 0.241 0.026 0.01 0.014 0.008 0.688 0.006 0.007
Turkey 6496 10 0.875 0.004 0.004 0.011 0.008 0.086 0.003 0.009
Turkey 6499 11 0.096 0.008 0.679 0.034 0.088 0.028 0.008 0.059
Turkey 6500 12 0.839 0.004 0.007 0.098 0.006 0.015 0.007 0.023
Turkey 6502 6 0.904 0.004 0.004 0.029 0.01 0.035 0.004 0.01
Turkey 6503 8 0.932 0.005 0.006 0.029 0.008 0.007 0.003 0.012
Turkey 6507 13 0.928 0.003 0.002 0.031 0.004 0.025 0.005 0.002
Turkey 6510 11 0.763 0.016 0.003 0.024 0.018 0.162 0.012 0.003
Turkey 6512 12 0.569 0.021 0.004 0.221 0.039 0.11 0.005 0.03
Turkey 6513 15 0.026 0.009 0.534 0.13 0.008 0.025 0.026 0.242
Turkey 6514 10 0.516 0.05 0.006 0.293 0.021 0.088 0.022 0.004
Turkey 6516 11 0.893 0.004 0.021 0.028 0.025 0.01 0.009 0.011
Turkey 6519 11 0.59 0.005 0.003 0.358 0.004 0.016 0.009 0.014
Turkey 6520 15 0.859 0.004 0.002 0.076 0.003 0.045 0.005 0.008
Turkey 6521 6 0.724 0.007 0.006 0.068 0.006 0.136 0.021 0.034
Turkey 6729 2 0.374 0.456 0.004 0.023 0.024 0.012 0.072 0.035
Turkey 6730 2 0.767 0.003 0.002 0.099 0.003 0.11 0.007 0.01
Turkey 6731 3 0.794 0.012 0.004 0.161 0.006 0.016 0.002 0.004
Turkey 6732 2 0.7 0.038 0.018 0.024 0.124 0.04 0.038 0.018
Turkey 6733 4 0.93 0.005 0.008 0.013 0.009 0.018 0.01 0.007
Turkey 6734 1 0.891 0.006 0.013 0.019 0.011 0.038 0.013 0.009
Turkey 6735 3 0.974 0.003 0.002 0.003 0.002 0.011 0.002 0.003
Turkey 6736 1 0.338 0.008 0.002 0.198 0.01 0.436 0.003 0.005
Turkey 6738 3 0.936 0.003 0.001 0.021 0.003 0.029 0.002 0.004
Turkey 6739 4 0.62 0.017 0.004 0.3 0.025 0.021 0.003 0.01
Turkey 6740 1 0.003 0.002 0.001 0.984 0.002 0.002 0.002 0.003
Turkey 6741 2 0.021 0.007 0.824 0.066 0.016 0.008 0.021 0.036
Turkey 6742 4 0.906 0.01 0.007 0.03 0.027 0.007 0.008 0.004
Turkey 6743 2 0.813 0.004 0.007 0.139 0.007 0.019 0.003 0.008
Turkey 6745 1 0.791 0.007 0.002 0.159 0.004 0.014 0.017 0.006
Turkey 6746 2 0.435 0.018 0.208 0.119 0.173 0.01 0.026 0.011 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Turkey 6748 3 0.829 0.01 0.017 0.033 0.026 0.047 0.004 0.035
Turkey 6749 2 0.824 0.007 0.013 0.135 0.004 0.01 0.004 0.002
Turkey 6750 3 0.571 0.002 0.002 0.371 0.004 0.043 0.003 0.005
Turkey 6753 2 0.706 0.028 0.005 0.167 0.02 0.042 0.028 0.004
Turkey 6754 3 0.914 0.033 0.004 0.032 0.004 0.007 0.003 0.003
Turkey 6755 3 0.918 0.005 0.003 0.05 0.003 0.011 0.007 0.003
Turkey 6756 2 0.782 0.003 0.002 0.187 0.003 0.018 0.002 0.004
Turkey 6758 3 0.755 0.009 0.005 0.066 0.017 0.118 0.025 0.005
Turkey 6759 4 0.832 0.004 0.003 0.085 0.011 0.045 0.008 0.013
Turkey 6760 2 0.77 0.005 0.002 0.189 0.003 0.006 0.003 0.021
Cyprus 10128 3 0.908 0.004 0.003 0.018 0.017 0.015 0.031 0.004
Cyprus 10129 1 0.478 0.008 0.004 0.354 0.006 0.136 0.005 0.008
Cyprus 10130 3 0.797 0.002 0.003 0.096 0.012 0.083 0.003 0.005
Cyprus 10131 1 0.735 0.008 0.022 0.027 0.116 0.061 0.026 0.005
Cyprus 10132 0 0.667 0.014 0.017 0.005 0.02 0.245 0.008 0.024
Cyprus 10133 3 0.892 0.008 0.01 0.035 0.009 0.032 0.006 0.008
Cyprus 10134 1 0.793 0.01 0.003 0.017 0.012 0.131 0.005 0.03
Cyprus 10135 2 0.576 0.004 0.004 0.042 0.033 0.245 0.01 0.085
Cyprus 10136 3 0.697 0.039 0.002 0.206 0.009 0.017 0.015 0.015
Cyprus 10137 1 0.886 0.061 0.002 0.007 0.006 0.026 0.01 0.003
Cyprus 10138 2 0.551 0.013 0.007 0.006 0.012 0.397 0.006 0.007
Cyprus 10139 3 0.386 0.026 0.027 0.014 0.082 0.389 0.044 0.032
Cyprus 10140 0 0.939 0.006 0.004 0.011 0.006 0.023 0.005 0.006
Cyprus 10141 1 0.828 0.004 0.003 0.04 0.007 0.106 0.006 0.007
Cyprus 10142 1 0.879 0.011 0.007 0.005 0.017 0.05 0.009 0.021
Cyprus 10143 1 0.858 0.006 0.002 0.005 0.005 0.115 0.007 0.003
Cyprus 10144 3 0.83 0.007 0.005 0.008 0.048 0.057 0.005 0.039
Cyprus 10145 2 0.942 0.004 0.002 0.027 0.003 0.015 0.004 0.003
Cyprus 10146 0 0.12 0.014 0.003 0.007 0.019 0.793 0.006 0.038
Cyprus 10147 2 0.968 0.002 0.002 0.012 0.003 0.007 0.002 0.004
Cyprus 10148 1 0.158 0.016 0.018 0.016 0.04 0.729 0.01 0.013
Cyprus 10149 3 0.772 0.093 0.006 0.024 0.025 0.039 0.007 0.033
Cyprus 10150 1 0.819 0.006 0.013 0.017 0.008 0.126 0.008 0.003
Cyprus 10151 2 0.913 0.009 0.005 0.005 0.014 0.041 0.009 0.004
Cyprus 10152 2 0.762 0.013 0.006 0.06 0.007 0.138 0.01 0.004
Cyprus 10153 1 0.945 0.008 0.002 0.005 0.004 0.011 0.021 0.004
Cyprus 10154 1 0.144 0.018 0.005 0.025 0.163 0.635 0.006 0.004
Cyprus 10155 3 0.885 0.003 0.009 0.004 0.016 0.022 0.005 0.056
Cyprus 10156 5 0.856 0.02 0.007 0.006 0.01 0.074 0.023 0.005
Cyprus 10157 2 0.239 0.127 0.005 0.011 0.005 0.6 0.005 0.007
Lebanon 10235 9 0.226 0.643 0.008 0.031 0.016 0.056 0.007 0.012
Lebanon 10236 6 0.411 0.555 0.006 0.005 0.006 0.009 0.004 0.003
Lebanon 10237 15 0.071 0.642 0.002 0.026 0.008 0.242 0.004 0.004
Lebanon 10238 18 0.083 0.787 0.007 0.01 0.018 0.065 0.026 0.005
Lebanon 10239 10 0.03 0.88 0.005 0.006 0.031 0.036 0.007 0.005
Lebanon 10240 3 0.108 0.645 0.005 0.008 0.046 0.074 0.098 0.017
Lebanon 10241 5 0.038 0.878 0.005 0.037 0.006 0.022 0.005 0.008
Lebanon 10242 1 0.12 0.778 0.005 0.012 0.037 0.037 0.007 0.004
Lebanon 10243 2 0.009 0.806 0.097 0.004 0.012 0.009 0.019 0.043
Lebanon 10244 4 0.084 0.777 0.003 0.08 0.015 0.027 0.006 0.009
Lebanon 10245 16 0.036 0.65 0.006 0.008 0.012 0.188 0.062 0.038
Lebanon 10246 15 0.314 0.593 0.003 0.007 0.016 0.054 0.005 0.009
Lebanon 10247 1 0.133 0.795 0.004 0.004 0.004 0.051 0.004 0.004
Lebanon 10248 1 0.016 0.738 0.024 0.008 0.183 0.015 0.01 0.006
Lebanon 10249 1 0.04 0.646 0.002 0.018 0.01 0.274 0.007 0.004
Lebanon 10250 1 0.021 0.837 0.057 0.046 0.007 0.02 0.008 0.004 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Lebanon 10251 14 0.012 0.878 0.007 0.006 0.025 0.014 0.008 0.052
Lebanon 10252 8 0.037 0.774 0.014 0.006 0.045 0.098 0.019 0.007
Lebanon 10253 19 0.08 0.836 0.004 0.005 0.015 0.021 0.011 0.027
Lebanon 10254 1 0.124 0.767 0.003 0.029 0.008 0.049 0.002 0.016
Lebanon 10255 2 0.168 0.618 0.004 0.118 0.005 0.076 0.005 0.006
Lebanon 10256 1 0.054 0.822 0.041 0.009 0.01 0.053 0.008 0.005
Lebanon 10257 3 0.027 0.833 0.006 0.025 0.009 0.085 0.007 0.009
Lebanon 10258 1 0.291 0.591 0.004 0.032 0.007 0.037 0.033 0.005
Lebanon 10259 3 0.19 0.585 0.036 0.006 0.035 0.075 0.069 0.004
Lebanon 10260 8 0.02 0.897 0.014 0.005 0.019 0.026 0.011 0.007
Lebanon 10261 7 0.202 0.66 0.007 0.078 0.006 0.033 0.007 0.006
Lebanon 10262 1 0.187 0.504 0.007 0.086 0.018 0.181 0.011 0.005
Lebanon 10263 2 0.021 0.503 0.003 0.008 0.025 0.41 0.01 0.02
Lebanon 10264 3 0.079 0.788 0.003 0.016 0.009 0.086 0.002 0.018
Lebanon 10265 3 0.017 0.485 0.007 0.003 0.005 0.46 0.01 0.012
Lebanon 10266 1 0.121 0.715 0.003 0.007 0.004 0.061 0.085 0.005
Lebanon 10267 4 0.052 0.742 0.046 0.005 0.088 0.02 0.015 0.031
Lebanon 10268 5 0.033 0.749 0.023 0.004 0.036 0.109 0.004 0.042
Lebanon 10270 3 0.031 0.67 0.007 0.004 0.006 0.252 0.02 0.01
Lebanon 10271 3 0.225 0.578 0.004 0.042 0.01 0.133 0.005 0.003
Lebanon 10273 1 0.021 0.71 0.053 0.006 0.188 0.009 0.007 0.006
Lebanon 10274 4 0.121 0.754 0.005 0.009 0.009 0.085 0.01 0.007
Lebanon 10276 2 0.193 0.585 0.003 0.044 0.007 0.13 0.032 0.006
Lebanon 10277 3 0.084 0.757 0.013 0.005 0.005 0.125 0.007 0.004
Lebanon 10278 2 0.298 0.593 0.004 0.057 0.009 0.021 0.011 0.007
Lebanon 10279 13 0.034 0.894 0.015 0.01 0.01 0.014 0.017 0.007
Lebanon 10280 0 0.048 0.682 0.029 0.002 0.114 0.119 0.004 0.003
Lebanon 10281 2 0.172 0.609 0.011 0.005 0.069 0.08 0.045 0.009
Lebanon 10282 15 0.021 0.668 0.007 0.008 0.13 0.136 0.008 0.022
Lebanon 10283 18 0.06 0.826 0.005 0.042 0.017 0.028 0.011 0.011
Lebanon 10284 14 0.02 0.742 0.007 0.008 0.026 0.03 0.153 0.013
Lebanon 10285 17 0.03 0.892 0.003 0.007 0.005 0.034 0.018 0.011
Lebanon 10286 15 0.036 0.752 0.002 0.006 0.008 0.062 0.125 0.008
Lebanon 10287 21 0.003 0.927 0.007 0.003 0.024 0.004 0.028 0.003
Lebanon 10288 4 0.006 0.949 0.006 0.002 0.007 0.008 0.016 0.006
Lebanon 10289 5 0.006 0.848 0.004 0.008 0.004 0.006 0.037 0.087
Lebanon 10290 3 0.006 0.949 0.013 0.004 0.007 0.007 0.004 0.01
Lebanon 10291 2 0.018 0.827 0.008 0.01 0.072 0.023 0.027 0.015
Lebanon 10292 3 0.022 0.73 0.019 0.008 0.066 0.021 0.093 0.041
Lebanon 10294 9 0.215 0.684 0.005 0.011 0.036 0.018 0.014 0.016
Lebanon 10295 1 0.012 0.7 0.006 0.004 0.23 0.017 0.016 0.014
Lebanon 10297 3 0.004 0.905 0.055 0.003 0.013 0.005 0.006 0.009
Lebanon 10298 2 0.022 0.841 0.007 0.023 0.02 0.014 0.067 0.006
Lebanon 10299 2 0.021 0.846 0.023 0.027 0.052 0.011 0.015 0.005
Lebanon 10300 2 0.003 0.943 0.015 0.003 0.012 0.005 0.009 0.01
Israel 4962 15 0.008 0.96 0.003 0.004 0.009 0.006 0.005 0.006
Israel 4963 1 0.006 0.953 0.004 0.003 0.008 0.004 0.004 0.017
Israel 4964 1 0.003 0.966 0.011 0.002 0.004 0.002 0.008 0.004
Israel 4966 1 0.007 0.924 0.004 0.006 0.008 0.005 0.025 0.022
Israel 4967 1 0.005 0.974 0.001 0.002 0.006 0.004 0.002 0.007
Israel 4968 2 0.002 0.982 0.001 0.002 0.004 0.002 0.003 0.004
Israel 4969 2 0.007 0.928 0.01 0.004 0.008 0.01 0.006 0.027
Israel 4970 2 0.004 0.965 0.008 0.004 0.007 0.003 0.004 0.005
Israel 4971 1 0.003 0.981 0.004 0.001 0.003 0.002 0.003 0.002
Israel 4972 2 0.002 0.985 0.002 0.001 0.002 0.002 0.003 0.002
Israel 4973 3 0.002 0.969 0.004 0.002 0.005 0.003 0.007 0.007 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Israel 4974 19 0.002 0.961 0.002 0.004 0.01 0.004 0.004 0.012
Israel 4975 3 0.003 0.978 0.002 0.002 0.003 0.003 0.003 0.005
Israel 4976 1 0.002 0.984 0.002 0.001 0.002 0.002 0.004 0.002
Israel 4977 2 0.004 0.971 0.002 0.003 0.003 0.005 0.008 0.003
Israel 4978 3 0.003 0.957 0.005 0.002 0.014 0.003 0.013 0.003
Israel 4979 1 0.003 0.973 0.008 0.004 0.005 0.002 0.003 0.003
Israel 4980 3 0.002 0.986 0.002 0.002 0.002 0.002 0.002 0.002
Israel 4981 1 0.002 0.986 0.002 0.001 0.002 0.002 0.002 0.002
Israel 4982 3 0.011 0.946 0.008 0.005 0.013 0.008 0.004 0.006
Israel 4983 3 0.003 0.972 0.004 0.003 0.007 0.003 0.004 0.004
Israel 4984 3 0.004 0.98 0.002 0.003 0.003 0.003 0.002 0.003
Israel 4985 1 0.002 0.981 0.002 0.001 0.003 0.002 0.005 0.004
Israel 4986 2 0.002 0.974 0.003 0.002 0.004 0.002 0.003 0.011
Israel 4988 2 0.007 0.941 0.007 0.006 0.007 0.007 0.013 0.013
Israel 4989 3 0.005 0.97 0.004 0.004 0.007 0.003 0.002 0.005
Israel 4990 2 0.004 0.956 0.004 0.006 0.011 0.002 0.004 0.012
Israel 4992 3 0.004 0.973 0.004 0.002 0.004 0.003 0.004 0.006
Israel 4993 2 0.002 0.972 0.005 0.002 0.005 0.003 0.008 0.003
Israel 4994 2 0.005 0.972 0.002 0.003 0.006 0.007 0.002 0.003
Israel 4995 3 0.004 0.904 0.003 0.003 0.006 0.008 0.003 0.069
Israel 4996 3 0.006 0.944 0.008 0.006 0.007 0.005 0.02 0.003
Israel 4997 2 0.007 0.923 0.008 0.01 0.007 0.009 0.031 0.005
Israel 4998 3 0.008 0.932 0.008 0.004 0.013 0.005 0.025 0.004
Israel 5000 2 0.014 0.95 0.003 0.012 0.007 0.005 0.005 0.005
Israel 5001 2 0.004 0.944 0.011 0.002 0.014 0.005 0.015 0.005
Israel 5002 1 0.002 0.971 0.002 0.003 0.004 0.002 0.004 0.011
Israel 5003 1 0.014 0.943 0.005 0.01 0.004 0.007 0.005 0.012
Israel 5004 2 0.007 0.964 0.002 0.004 0.006 0.005 0.004 0.009
Israel 5005 3 0.003 0.976 0.002 0.003 0.002 0.004 0.006 0.004
Israel 5006 2 0.006 0.957 0.012 0.005 0.006 0.005 0.007 0.002
Israel 5007 1 0.009 0.862 0.008 0.005 0.018 0.007 0.02 0.073
Israel 5008 2 0.002 0.984 0.002 0.002 0.002 0.003 0.003 0.002
Israel 5009 3 0.005 0.938 0.011 0.003 0.028 0.004 0.004 0.006
Israel 5010 3 0.004 0.925 0.014 0.01 0.012 0.005 0.027 0.005
Israel 5011 2 0.005 0.921 0.005 0.006 0.029 0.005 0.017 0.013
Egypt-Cairo 8190 4 0.016 0.714 0.008 0.007 0.013 0.009 0.23 0.004
Egypt-Cairo 8192 2 0.128 0.712 0.003 0.017 0.031 0.103 0.003 0.004
Egypt-Cairo 8193 2 0.006 0.886 0.004 0.002 0.007 0.004 0.086 0.005
Egypt-Cairo 8196 3 0.004 0.965 0.002 0.007 0.005 0.003 0.003 0.01
Egypt-Cairo 8203 2 0.005 0.947 0.003 0.003 0.021 0.006 0.005 0.009
Egypt-Cairo 8215 3 0.022 0.934 0.015 0.007 0.011 0.007 0.003 0.002
Egypt-Cairo 8198 3 0.012 0.913 0.004 0.006 0.032 0.011 0.004 0.016
Egypt-Cairo 8194 3 0.003 0.968 0.002 0.004 0.006 0.002 0.009 0.005
Egypt-Cairo 8211 2 0.002 0.981 0.003 0.002 0.003 0.002 0.004 0.003
Egypt-Cairo 8216 3 0.005 0.965 0.005 0.004 0.008 0.005 0.002 0.005
Egypt-Cairo 8195 1 0.004 0.963 0.005 0.004 0.005 0.003 0.012 0.004
Egypt-Cairo 8199 2 0.003 0.981 0.002 0.002 0.003 0.003 0.002 0.003
Egypt-Cairo 8200 1 0.002 0.967 0.004 0.003 0.003 0.002 0.003 0.016
Egypt-Cairo 8201 3 0.003 0.938 0.002 0.002 0.003 0.003 0.005 0.045
Egypt-Cairo 8202 2 0.003 0.978 0.002 0.002 0.003 0.002 0.006 0.003
Egypt-Cairo 8204 3 0.004 0.926 0.004 0.003 0.004 0.004 0.046 0.01
Egypt-Cairo 8208 2 0.002 0.973 0.004 0.002 0.004 0.002 0.003 0.011
Egypt-Cairo 8210 1 0.007 0.907 0.005 0.024 0.025 0.012 0.003 0.017
Egypt-Cairo 8214 4 0.007 0.951 0.006 0.003 0.006 0.008 0.016 0.002
Egypt-Cairo 8191 3 0.004 0.945 0.006 0.008 0.014 0.004 0.004 0.014
Egypt-Cairo 8197 2 0.002 0.988 0.001 0.002 0.002 0.002 0.002 0.002 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Egypt-Cairo 8205 2 0.002 0.986 0.002 0.002 0.002 0.002 0.003 0.002
Egypt-Cairo 8206 6 0.006 0.872 0.013 0.027 0.037 0.005 0.005 0.034
Egypt-Cairo 8207 6 0.017 0.828 0.003 0.037 0.042 0.018 0.021 0.035
Egypt-Cairo 8209 3 0.003 0.947 0.004 0.002 0.004 0.003 0.013 0.023
Egypt-Cairo 8212 5 0.005 0.946 0.004 0.004 0.004 0.003 0.031 0.005
Egypt-Cairo 8213 4 0.003 0.947 0.003 0.002 0.004 0.002 0.034 0.005
Egypt-Cairo 9942 3 0.006 0.967 0.003 0.005 0.006 0.004 0.005 0.003
Egypt-Cairo 9943 6 0.009 0.92 0.003 0.005 0.003 0.004 0.007 0.049
Egypt-Cairo 9944 5 0.01 0.944 0.003 0.004 0.009 0.004 0.004 0.023
Egypt-Cairo 9945 4 0.12 0.814 0.01 0.008 0.01 0.019 0.007 0.012
Egypt-Cairo 9946 4 0.004 0.951 0.011 0.005 0.01 0.003 0.003 0.013
Egypt-Cairo 9947 7 0.005 0.925 0.005 0.004 0.005 0.004 0.004 0.048
Egypt-Cairo 9948 3 0.007 0.934 0.006 0.006 0.006 0.004 0.031 0.006
Egypt-Cairo 9949 3 0.012 0.914 0.012 0.009 0.026 0.006 0.005 0.017
Egypt-Cairo 9950 4 0.01 0.945 0.005 0.013 0.009 0.005 0.004 0.009
Egypt-Cairo 9951 4 0.005 0.909 0.002 0.005 0.007 0.004 0.002 0.067
Egypt-Cairo 9952 8 0.004 0.827 0.003 0.004 0.027 0.003 0.007 0.124
Egypt-Cairo 9953 9 0.043 0.889 0.009 0.003 0.018 0.018 0.015 0.005
Egypt-Cairo 9954 3 0.019 0.891 0.002 0.018 0.009 0.024 0.005 0.033
Egypt-Cairo 9955 3 0.002 0.963 0.002 0.001 0.004 0.002 0.022 0.003
Egypt-Cairo 9956 4 0.002 0.963 0.002 0.001 0.004 0.002 0.022 0.004
Egypt-Cairo 9957 3 0.008 0.877 0.006 0.005 0.076 0.008 0.014 0.006
Egypt-Cairo 9958 5 0.002 0.976 0.004 0.002 0.003 0.002 0.005 0.005
Egypt-Cairo 9959 4 0.002 0.966 0.005 0.002 0.013 0.002 0.007 0.002
Egypt-Cairo 9960 5 0.003 0.972 0.002 0.003 0.004 0.004 0.009 0.003
Egypt-Cairo 9961 4 0.017 0.84 0.007 0.007 0.061 0.027 0.018 0.023
Egypt-Cairo 9962 14 0.044 0.872 0.041 0.016 0.009 0.011 0.003 0.005
Egypt-Cairo 9963 1 0.084 0.107 0.002 0.012 0.144 0.025 0.002 0.625
Egypt-Cairo 9964 2 0.011 0.259 0.021 0.013 0.039 0.025 0.014 0.617
Egypt-Cairo 10021 4 0.007 0.044 0.005 0.003 0.488 0.004 0.004 0.444
Egypt-Cairo 10022 1 0.014 0.431 0.01 0.032 0.062 0.034 0.099 0.318
Egypt-Cairo 10023 2 0.022 0.033 0.016 0.007 0.487 0.042 0.028 0.364
Egypt-Cairo 10024 4 0.009 0.33 0.012 0.006 0.041 0.005 0.178 0.42
Egypt-Cairo 10025 3 0.015 0.18 0.005 0.015 0.012 0.01 0.008 0.755
Egypt-Cairo 10026 4 0.006 0.042 0.003 0.003 0.395 0.007 0.003 0.542
Egypt-Cairo 10027 2 0.169 0.077 0.025 0.006 0.221 0.013 0.026 0.463
Egypt-Cairo 10028 3 0.01 0.18 0.004 0.005 0.083 0.008 0.011 0.699
Egypt-Cairo 10029 19 0.078 0.04 0.04 0.022 0.068 0.716 0.023 0.014
Egypt-Cairo 10030 22 0.797 0.008 0.007 0.005 0.067 0.053 0.029 0.035
Egypt-Cairo 10031 16 0.668 0.005 0.046 0.01 0.116 0.032 0.077 0.045
Egypt-Cairo 10032 3 0.324 0.053 0.016 0.051 0.03 0.51 0.006 0.01
Egypt-Cairo 10033 14 0.908 0.007 0.004 0.009 0.007 0.057 0.004 0.006
Egypt-Cairo 10034 19 0.87 0.014 0.016 0.012 0.045 0.029 0.008 0.006
Egypt-Cairo 10035 6 0.772 0.02 0.01 0.015 0.038 0.015 0.123 0.008
Egypt-Cairo 10037 2 0.806 0.014 0.016 0.05 0.011 0.084 0.006 0.013
Egypt-Cairo 10042 3 0.867 0.053 0.011 0.008 0.021 0.02 0.012 0.009
Egypt-Cairo 10043 15 0.809 0.026 0.004 0.007 0.063 0.054 0.027 0.01
Egypt-Cairo 10044 7 0.717 0.164 0.01 0.014 0.018 0.05 0.005 0.021
Egypt-Cairo 10045 15 0.658 0.036 0.014 0.019 0.014 0.251 0.003 0.005
Egypt-Cairo 10046 24 0.199 0.252 0.005 0.004 0.011 0.505 0.009 0.015
Egypt-Cairo 10047 19 0.6 0.008 0.006 0.02 0.005 0.251 0.008 0.104
Egypt-Cairo 10048 17 0.595 0.005 0.007 0.359 0.01 0.013 0.004 0.006
Egypt-Cairo 10083 22 0.887 0.051 0.003 0.014 0.005 0.024 0.011 0.006
Egypt-Cairo 10040 3 0.92 0.007 0.004 0.007 0.012 0.022 0.004 0.025
Egypt-Cairo 10041 12 0.802 0.065 0.007 0.079 0.012 0.016 0.008 0.011
Egypt-Cairo 10049 6 0.741 0.051 0.012 0.009 0.004 0.089 0.011 0.083 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Egypt-Cairo 10084 13 0.925 0.006 0.008 0.005 0.01 0.019 0.017 0.01
Egypt-Cairo 10085 7 0.4 0.177 0.022 0.047 0.011 0.328 0.011 0.005
Egypt-Cairo 10087 12 0.661 0.012 0.004 0.009 0.006 0.295 0.006 0.008
Egypt-Cairo 10090 3 0.88 0.009 0.032 0.008 0.026 0.027 0.011 0.006
Egypt-Cairo 9968 17 0.196 0.023 0.008 0.007 0.016 0.702 0.021 0.028
Egypt-Asuit 10091 2 0.037 0.005 0.553 0.021 0.014 0.36 0.006 0.005
Egypt-Asuit 10093 14 0.953 0.008 0.004 0.005 0.004 0.017 0.004 0.006
Egypt-Asuit 10094 13 0.865 0.018 0.016 0.008 0.015 0.061 0.012 0.003
Egypt-Asuit 10095 18 0.898 0.019 0.009 0.009 0.013 0.032 0.013 0.006
Egypt-Asuit 10096 3 0.893 0.009 0.006 0.007 0.008 0.064 0.004 0.008
Egypt-Asuit 10098 3 0.894 0.009 0.009 0.03 0.025 0.014 0.011 0.008
Egypt-Asuit 10099 9 0.889 0.022 0.004 0.005 0.007 0.065 0.004 0.004
Egypt-Asuit 10100 4 0.082 0.006 0.026 0.006 0.135 0.728 0.008 0.009
Egypt-Asuit 10101 13 0.519 0.007 0.003 0.364 0.003 0.094 0.004 0.005
Egypt-Asuit 10102 15 0.046 0.003 0.133 0.015 0.004 0.782 0.007 0.009
Egypt-Luxor 10038 10 0.168 0.023 0.341 0.038 0.009 0.399 0.009 0.012
Egypt-Luxor 10039 4 0.685 0.068 0.035 0.014 0.114 0.01 0.013 0.062
Egypt-Luxor 10050 5 0.685 0.022 0.032 0.071 0.02 0.065 0.096 0.009
Egypt-Luxor 10051 5 0.365 0.004 0.065 0.062 0.051 0.416 0.015 0.021
Egypt-Luxor 10052 5 0.369 0.017 0.003 0.008 0.007 0.582 0.003 0.011
Egypt-Luxor 10053 4 0.605 0.018 0.011 0.091 0.032 0.1 0.14 0.003
Egypt-Luxor 10054 5 0.382 0.043 0.003 0.012 0.012 0.489 0.032 0.027
Egypt-Luxor 10055 1 0.897 0.03 0.004 0.005 0.032 0.01 0.004 0.018
Egypt-Luxor 10056 2 0.725 0.011 0.018 0.011 0.173 0.027 0.012 0.021
Egypt-Luxor 10057 8 0.911 0.012 0.003 0.007 0.005 0.048 0.007 0.006
Egypt-Luxor 10058 3 0.395 0.014 0.04 0.008 0.018 0.505 0.015 0.006
Egypt-Luxor 10060 18 0.847 0.005 0.002 0.004 0.009 0.033 0.004 0.095
Egypt-Luxor 10061 16 0.254 0.159 0.038 0.026 0.042 0.428 0.017 0.037
Egypt-Luxor 10062 1 0.246 0.012 0.024 0.014 0.009 0.642 0.008 0.045
Egypt-Luxor 10063 5 0.614 0.097 0.14 0.008 0.1 0.018 0.015 0.007
Egypt-Luxor 10064 2 0.413 0.041 0.012 0.287 0.073 0.132 0.033 0.008
Egypt-Luxor 10065 22 0.081 0.004 0.006 0.81 0.009 0.031 0.055 0.005
Egypt-Luxor 10066 4 0.875 0.025 0.004 0.004 0.022 0.057 0.008 0.006
Egypt-Luxor 10067 3 0.687 0.02 0.018 0.006 0.108 0.065 0.051 0.045
Egypt-Luxor 10068 9 0.589 0.088 0.004 0.011 0.058 0.147 0.056 0.047
Egypt-Luxor 10069 7 0.62 0.032 0.033 0.016 0.187 0.043 0.006 0.064
Egypt-Luxor 10070 8 0.781 0.009 0.159 0.007 0.007 0.022 0.006 0.008
Egypt-Luxor 10071 6 0.37 0.08 0.025 0.045 0.034 0.398 0.03 0.019
Egypt-Luxor 10072 5 0.697 0.203 0.008 0.014 0.019 0.04 0.014 0.005
Egypt-Luxor 10073 8 0.516 0.219 0.005 0.005 0.053 0.164 0.015 0.022
Egypt-Luxor 10074 17 0.371 0.074 0.024 0.241 0.03 0.146 0.024 0.089
Egypt-Luxor 10079 20 0.927 0.015 0.017 0.005 0.016 0.01 0.006 0.005
Egypt-Luxor 10080 1 0.831 0.062 0.002 0.021 0.017 0.035 0.006 0.027
Egypt-Abu Simbel 10076 1 0.923 0.005 0.006 0.007 0.024 0.012 0.012 0.01
Egypt-Abu Simbel 10077 2 0.824 0.048 0.01 0.025 0.016 0.068 0.006 0.003
Egypt-Abu Simbel 10081 2 0.91 0.004 0.008 0.007 0.011 0.042 0.003 0.015
Egypt-Abu Simbel 10089 2 0.771 0.024 0.006 0.064 0.023 0.03 0.024 0.057
Egypt-Abu Simbel 10092 3 0.87 0.012 0.011 0.005 0.033 0.031 0.033 0.005
Iraq-West 9587 1 0.218 0.013 0.107 0.541 0.027 0.024 0.056 0.013
Iraq-West 10202 1 0.931 0.009 0.013 0.015 0.007 0.012 0.007 0.006
Iraq-West 10204 1 0.961 0.01 0.003 0.004 0.004 0.007 0.006 0.003
Iraq-West 11854 2 0.914 0.006 0.005 0.01 0.004 0.011 0.024 0.026
Iraq-West 11860 2 0.913 0.004 0.004 0.004 0.005 0.007 0.008 0.053
Iraq-West 11861 2 0.95 0.009 0.005 0.01 0.008 0.008 0.005 0.005
Iraq-West 11863 1 0.95 0.004 0.006 0.017 0.007 0.011 0.003 0.003
Iraq-West 11864 1 0.814 0.013 0.034 0.042 0.014 0.035 0.004 0.043 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iraq-West 11888 3 0.854 0.022 0.004 0.095 0.008 0.008 0.003 0.006
Iraq-West 11889 3 0.915 0.031 0.011 0.007 0.009 0.005 0.009 0.014
Iraq-West 11890 2 0.925 0.025 0.005 0.007 0.004 0.016 0.009 0.01
Iraq-West 11891 1 0.794 0.03 0.005 0.069 0.039 0.019 0.024 0.021
Iraq-Baghdad 11847 5 0.402 0.024 0.005 0.008 0.01 0.196 0.352 0.003
Iraq-Baghdad 11848 4 0.861 0.005 0.011 0.023 0.069 0.018 0.004 0.009
Iraq-Baghdad 11849 1 0.183 0.055 0.242 0.425 0.017 0.037 0.032 0.009
Iraq-Baghdad 11850 2 0.052 0.015 0.25 0.636 0.011 0.013 0.01 0.012
Iraq-Baghdad 11852 17 0.861 0.005 0.007 0.013 0.029 0.065 0.016 0.003
Iraq-Baghdad 11853 2 0.952 0.008 0.007 0.003 0.01 0.007 0.007 0.005
Iraq-Baghdad 11855 3 0.901 0.01 0.015 0.009 0.021 0.016 0.017 0.01
Iraq-Baghdad 11856 4 0.749 0.023 0.062 0.007 0.061 0.079 0.016 0.002
Iraq-Baghdad 11857 2 0.695 0.005 0.126 0.008 0.031 0.054 0.078 0.003
Iraq-Baghdad 11858 6 0.955 0.007 0.003 0.009 0.004 0.008 0.005 0.009
Iraq-Baghdad 11859 9 0.927 0.005 0.004 0.005 0.004 0.012 0.005 0.04
Iraq-Baghdad 11862 2 0.976 0.002 0.001 0.003 0.004 0.009 0.003 0.003
Iraq-Baghdad 11865 2 0.837 0.01 0.084 0.008 0.021 0.016 0.021 0.002
Iraq-Baghdad 11868 1 0.76 0.009 0.005 0.005 0.004 0.178 0.037 0.002
Iraq-Baghdad 11869 3 0.808 0.038 0.089 0.006 0.013 0.033 0.01 0.003
Iraq-Baghdad 11870 2 0.879 0.028 0.006 0.037 0.025 0.011 0.006 0.007
Iraq-Baghdad 11871 2 0.923 0.007 0.033 0.005 0.009 0.013 0.005 0.005
Iraq-Baghdad 11872 2 0.755 0.006 0.006 0.169 0.02 0.032 0.008 0.005
Iraq-Baghdad 11873 2 0.915 0.003 0.016 0.009 0.01 0.022 0.005 0.02
Iraq-Baghdad 11874 2 0.782 0.014 0.009 0.044 0.018 0.024 0.092 0.016
Iraq-Baghdad 11875 3 0.674 0.013 0.25 0.011 0.01 1 0.03 0.004 0.007
Iraq-Baghdad 11876 2 0.896 0.005 0.004 0.05 0.005 0.026 0.003 0.011
Iraq-Baghdad 11877 3 0.654 0.013 0.003 0.018 0.007 0.297 0.004 0.004
Iraq-Baghdad 11878 2 0.706 0.004 0.059 0.022 0.023 0.037 0.124 0.024
Iraq-Baghdad 11879 1 0.701 0.012 0.028 0.022 0.006 0.167 0.007 0.058
Iraq-Baghdad 11880 3 0.53 0.041 0.275 0.015 0.007 0.12 0.007 0.004
Iraq-Baghdad 11881 4 0.964 0.003 0.002 0.006 0.004 0.015 0.002 0.003
Iraq-Baghdad 11882 2 0.955 0.007 0.009 0.005 0.006 0.009 0.005 0.004
Iraq-Baghdad 11883 3 0.012 0.007 0.013 0.032 0.01 0.914 0.006 0.007
Iraq-Baghdad 11884 5 0.057 0.023 0.01 0.143 0.017 0.667 0.005 0.078
Iraq-Baghdad 11885 4 0.03 0.027 0.003 0.018 0.019 0.891 0.005 0.007
Iraq-Baghdad 11886 4 0.034 0.012 0.015 0.004 0.04 0.864 0.017 0.014
Iraq-Baghdad 11887 4 0.039 0.005 0.017 0.012 0.008 0.908 0.007 0.003
Iran 9419 3 0.03 0.008 0.004 0.007 0.025 0.917 0.006 0.004
Iran 9420 3 0.016 0.01 0.01 0.026 0.009 0.91 0.006 0.012
Iran 9421 1 0.022 0.015 0.015 0.105 0.008 0.814 0.009 0.012
Iran 9422 9 0.673 0.007 0.003 0.006 0.003 0.301 0.004 0.003
Iran 9424 2 0.039 0.008 0.025 0.12 0.006 0.79 0.004 0.008
Iran 9425 2 0.325 0.01 0.004 0.022 0.014 0.58 0.012 0.032
Iran 9426 8 0.025 0.005 0.002 0.005 0.016 0.923 0.005 0.018
Iran 9427 13 0.273 0.015 0.003 0.042 0.005 0.654 0.006 0.002
Iran 9428 1 0.491 0.077 0.007 0.037 0.069 0.27 0.029 0.019
Iran 9429 2 0.035 0.047 0.616 0.011 0.112 0.157 0.01 0.013
Iran 9430 2 0.133 0.003 0.006 0.01 0.013 0.822 0.008 0.005
Iran 9431 1 0.081 0.022 0.005 0.012 0.027 0.829 0.019 0.006
Iran 9432 3 0.174 0.065 0.004 0.007 0.042 0.681 0.008 0.021
Iran 9433 2 0.01 0.009 0.004 0.005 0.006 0.957 0.006 0.003
Iran 9434 2 0.373 0.025 0.011 0.016 0.011 0.537 0.02 0.007
Iran 9435 1 0.064 0.008 0.009 0.006 0.01 0.851 0.003 0.05
Iran 9436 1 0.08 0.023 0.004 0.012 0.057 0.788 0.032 0.005
Iran 9437 1 0.034 0.006 0.012 0.005 0.026 0.904 0.007 0.004
Iran 9438 2 0.008 0.006 0.028 0.009 0.009 0.92 0.01 0.011 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iran 9439 1 0.175 0.007 0.002 0.016 0.007 0.784 0.006 0.002
Iran 9440 1 0.004 0.007 0.003 0.005 0.007 0.968 0.004 0.002
Iran 9441 1 0.007 0.007 0.003 0.008 0.007 0.961 0.005 0.003
Iran 9442 2 0.071 0.169 0.015 0.006 0.006 0.709 0.015 0.008
Iran 9443 3 0.013 0.007 0.513 0.355 0.07 0.034 0.005 0.002
Iran 9444 4 0.023 0.139 0.005 0.344 0.007 0.47 0.003 0.009
Iran 9445 0 0.022 0.016 0.007 0.014 0.027 0.897 0.005 0.012
Iran 9446 3 0.409 0.008 0.034 0.009 0.023 0.486 0.015 0.016
Iran 9447 3 0.041 0.053 0.004 0.007 0.014 0.821 0.006 0.054
Iran 9448 0 0.127 0.005 0.014 0.076 0.006 0.767 0.003 0.003
Iran 9449 0 0.027 0.006 0.027 0.016 0.024 0.886 0.009 0.004
Iran 9450 1 0.117 0.004 0.002 0.056 0.008 0.802 0.005 0.006
Iran 9451 2 0.036 0.004 0.009 0.009 0.014 0.91 0.007 0.012
Iran 9452 4 0.468 0.015 0.003 0.007 0.008 0.476 0.004 0.02
Iran 9453 8 0.449 0.071 0.01 0.426 0.013 0.022 0.005 0.004
Iran 9454 1 0.005 0.002 0.186 0.004 0.007 0.725 0.052 0.017
Iran 9455 2 0.015 0.005 0.039 0.381 0.185 0.361 0.006 0.007
Iran 9456 8 0.016 0.007 0.035 0.01 0.011 0.825 0.089 0.008
Iran 9457 2 0.047 0.016 0.006 0.032 0.014 0.751 0.129 0.005
Iran 9458 4 0.031 0.006 0.108 0.011 0.005 0.82 0.008 0.01
Iran 9459 2 0.271 0.009 0.008 0.071 0.49 0.136 0.008 0.007
Iran 9460 1 0.054 0.046 0.013 0.011 0.007 0.854 0.011 0.003
Iran 9461 5 0.029 0.006 0.393 0.012 0.054 0.491 0.012 0.004
Iran 9462 3 0.032 0.013 0.009 0.027 0.007 0.849 0.005 0.058
Iran 9463 3 0.066 0.007 0.009 0.016 0.004 0.871 0.012 0.015
Iran 9464 1 0.093 0.007 0.066 0.021 0.032 0.772 0.004 0.006
Iran 9465 6 0.01 0.005 0.002 0.004 0.003 0.964 0.003 0.009
Iran 9466 1 0.005 0.003 0.003 0.005 0.006 0.97 0.005 0.003
Iran 9468 0 0.119 0.005 0.003 0.003 0.01 0.851 0.004 0.005
Iran 9469 1 0.009 0.002 0.002 0.009 0.003 0.971 0.002 0.002
Iran 9470 2 0.933 0.015 0.004 0.01 0.01 0.019 0.004 0.006
Iran 9471 17 0.095 0.004 0.003 0.031 0.006 0.821 0.036 0.005
Iran 9472 1 0.009 0.007 0.004 0.011 0.023 0.91 0.005 0.031
Iran 9473 1 0.012 0.011 0.003 0.004 0.005 0.957 0.004 0.004
Iran 9474 3 0.006 0.008 0.001 0.004 0.003 0.971 0.003 0.004
Iran 9475 1 0.008 0.003 0.004 0.007 0.004 0.969 0.004 0.002
Iran 9476 3 0.009 0.006 0.002 0.002 0.003 0.97 0.003 0.005
Iran 9477 0 0.008 0.012 0.002 0.003 0.004 0.966 0.002 0.003
Iran 9478 1 0.077 0.006 0.003 0.003 0.007 0.895 0.005 0.005
Iran 9479 1 0.012 0.003 0.003 0.008 0.004 0.962 0.003 0.006
Iran 9480 3 0.031 0.011 0.003 0.006 0.017 0.789 0.106 0.037
Iran 9481 5 0.011 0.007 0.003 0.243 0.007 0.694 0.005 0.031
Iran 9482 1 0.06 0.015 0.014 0.05 0.014 0.804 0.01 0.033
Iran 9483 2 0.286 0.008 0.005 0.043 0.013 0.636 0.002 0.008
Iran 9484 4 0.011 0.005 0.004 0.008 0.006 0.953 0.008 0.004
Iran 9485 1 0.058 0.004 0.006 0.05 0.006 0.865 0.003 0.007
Iran 9486 0 0.014 0.004 0.007 0.008 0.011 0.941 0.01 0.004
Iran 9487 0 0.005 0.007 0.004 0.004 0.012 0.961 0.004 0.003
Iran 9488 1 0.021 0.003 0.014 0.009 0.018 0.904 0.025 0.006
Iran 9489 24 0.069 0.005 0.007 0.052 0.006 0.843 0.009 0.009
Iran 9490 2 0.149 0.007 0.005 0.047 0.025 0.741 0.014 0.011
Iran 9491 1 0.372 0.008 0.004 0.022 0.03 0.515 0.018 0.031
Iran 9492 9 0.061 0.016 0.007 0.009 0.052 0.827 0.014 0.014
Iran 9493 7 0.019 0.004 0.024 0.019 0.006 0.89 0.006 0.032
Iran 9494 19 0.362 0.003 0.024 0.062 0.009 0.486 0.003 0.051
Iran 9495 4 0.059 0.002 0.003 0.015 0.003 0.903 0.003 0.012 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Iran 9497 4 0.049 0.007 0.01 0.023 0.02 0.784 0.008 0.098
Iran 9498 0 0.027 0.015 0.004 0.015 0.007 0.905 0.005 0.022
Iran 9499 1 0.005 0.003 0.002 0.007 0.006 0.973 0.003 0.002
Iran 9500 3 0.005 0.002 0.001 0.008 0.004 0.974 0.003 0.004
Iran 9501 4 0.006 0.002 0.002 0.008 0.006 0.967 0.003 0.005
Iran 9502 13 0.024 0.005 0.005 0.019 0.006 0.933 0.003 0.006
Iran 9503 1 0.006 0.002 0.002 0.006 0.005 0.962 0.013 0.003
Iran 9504 1 0.004 0.002 0.001 0.006 0.003 0.978 0.003 0.004
Iran 9505 1 0.005 0.003 0.001 0.003 0.003 0.975 0.003 0.007
Iran 9506 2 0.107 0.013 0.014 0.079 0.015 0.536 0.059 0.177
Iran 9507 2 0.016 0.013 0.004 0.004 0.016 0.93 0.01 0.006
Iran 9508 1 0.031 0.006 0.028 0.004 0.023 0.893 0.008 0.006
Iran 9509 1 0.008 0.003 0.074 0.004 0.009 0.885 0.009 0.007
Iran 9510 5 0.004 0.006 0.002 0.003 0.003 0.978 0.002 0.002
Iran 9511 2 0.014 0.006 0.006 0.004 0.016 0.928 0.021 0.005
Iran 9512 1 0.022 0.002 0.003 0.004 0.004 0.95 0.004 0.011
Iran 9513 11 0.014 0.004 0.011 0.008 0.024 0.921 0.007 0.011
Iran 9514 2 0.038 0.091 0.019 0.006 0.018 0.798 0.007 0.024
Iran 9515 2 0.015 0.007 0.003 0.005 0.006 0.945 0.018 0.002
Iran 9516 1 0.024 0.007 0.01 0.004 0.006 0.932 0.005 0.013
Iran 9517 2 0.017 0.011 0.009 0.009 0.01 0.917 0.018 0.01
Iran 9518 12 0.167 0.021 0.003 0.009 0.018 0.762 0.016 0.004
Iran 9519 6 0.008 0.004 0.002 0.006 0.003 0.966 0.005 0.006
Iran 9520 4 0.108 0.004 0.003 0.027 0.005 0.836 0.005 0.013
Iran 9521 0 0.007 0.003 0.1 0.01 0.007 0.823 0.039 0.012
Iran 9522 3 0.058 0.008 0.003 0.019 0.006 0.893 0.005 0.008
Iran 9523 1 0.153 0.089 0.018 0.07 0.079 0.552 0.015 0.024
Iran 9524 1 0.034 0.004 0.002 0.044 0.017 0.851 0.005 0.043
Iran 9526 0 0.015 0.011 0.01 0.012 0.018 0.772 0.005 0.158
Iran 9527 3 0.008 0.005 0.011 0.015 0.019 0.906 0.015 0.022
Iran 9528 4 0.028 0.014 0.002 0.004 0.008 0.935 0.003 0.006
Iran 9529 7 0.013 0.002 0.006 0.013 0.039 0.899 0.023 0.004
Iran 9530 3 0.034 0.017 0.003 0.004 0.007 0.907 0.004 0.023
Iran 9531 1 0.007 0.003 0.105 0.013 0.006 0.823 0.033 0.01
Iran 9532 3 0.025 0.009 0.003 0.004 0.048 0.898 0.007 0.005
Dubai 10104 2 0.102 0.007 0.004 0.009 0.005 0.842 0.018 0.013
Dubai 10105 1 0.004 0.004 0.002 0.948 0.007 0.024 0.006 0.006
Dubai 10106 0 0.018 0.004 0.002 0.004 0.002 0.964 0.002 0.003
Dubai 10107 4 0.072 0.004 0.007 0.098 0.172 0.64 0.003 0.005
Dubai 10108 5 0.017 0.004 0.022 0.011 0.015 0.697 0.005 0.23
Dubai 10109 10 0.051 0.006 0.009 0.013 0.023 0.859 0.026 0.014
Dubai 10110 17 0.014 0.004 0.005 0.004 0.011 0.948 0.008 0.006
Dubai 10111 17 0.163 0.007 0.011 0.011 0.008 0.752 0.007 0.041
Dubai 10112 1 0.021 0.002 0.003 0.062 0.004 0.885 0.002 0.022
Dubai 10120 2 0.008 0.002 0.002 0.004 0.003 0.968 0.004 0.009
Kenya-Nairobi 9833 4 0.012 0.229 0.031 0.678 0.022 0.005 0.008 0.016
Kenya-Nairobi 9834 0 0.013 0.008 0.008 0.516 0.376 0.029 0.039 0.012
Kenya-Nairobi 9835 0 0.015 0.007 0.02 0.043 0.093 0.708 0.022 0.093
Kenya-Nairobi 9836 2 0.009 0.004 0.138 0.637 0.09 0.008 0.01 0.104
Kenya-Nairobi 9837 2 0.008 0.024 0.062 0.74 0.092 0.036 0.032 0.006
Kenya-Nairobi 9838 4 0.208 0.082 0.005 0.521 0.035 0.07 0.008 0.071
Kenya-Nairobi 9839 1 0.011 0.015 0.061 0.509 0.062 0.015 0.033 0.295
Kenya-Nairobi 9840 3 0.058 0.018 0.045 0.592 0.193 0.065 0.004 0.026
Kenya-Nairobi 9841 3 0.012 0.011 0.026 0.777 0.057 0.012 0.012 0.093
Kenya-Nairobi 9842 2 0.015 0.016 0.009 0.567 0.02 0.061 0.035 0.277
Kenya-Nairobi 9843 4 0.009 0.014 0.149 0.62 0.093 0.028 0.008 0.078 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Kenya-Nairobi 9844 3 0.006 0.006 0.064 0.681 0.009 0.012 0.026 0.195
Kenya-Nairobi 9845 1 0.042 0.011 0.018 0.657 0.068 0.121 0.018 0.065
Kenya-Nairobi 9846 1 0.086 0.035 0.184 0.558 0.08 0.012 0.01 0.037
Kenya-Nairobi 9847 3 0.018 0.01 0.005 0.739 0.106 0.006 0.018 0.098
Kenya-Nairobi 9848 3 0.051 0.011 0.008 0.594 0.032 0.115 0.048 0.143
Kenya-Nairobi 9849 2 0.018 0.003 0.013 0.311 0.607 0.014 0.014 0.021
Kenya-Nairobi 9850 3 0.136 0.03 0.016 0.722 0.056 0.011 0.006 0.024
Kenya-Nairobi 9851 2 0.016 0.01 0.033 0.428 0.474 0.007 0.006 0.026
Kenya-Nairobi 9852 4 0.034 0.006 0.074 0.44 0.039 0.049 0.004 0.355
Kenya-Nairobi 9853 4 0.008 0.037 0.044 0.614 0.123 0.011 0.012 0.151
Kenya-Nairobi 9854 2 0.117 0.055 0.028 0.606 0.098 0.044 0.005 0.048
Kenya-Nairobi 9855 2 0.047 0.025 0.033 0.552 0.121 0.042 0.009 0.17
Kenya-Nairobi 9856 3 0.018 0.006 0.087 0.573 0.066 0.028 0.004 0.217
Kenya-Nairobi 9857 6 0.018 0.01 0.123 0.668 0.14 0.021 0.012 0.008
Kenya-Nairobi 9858 3 0.006 0.009 0.009 0.651 0.096 0.008 0.035 0.185
Kenya-Nairobi 9859 4 0.005 0.008 0.182 0.699 0.004 0.005 0.013 0.085
Kenya-Nairobi 9860 2 0.004 0.008 0.132 0.694 0.024 0.012 0.031 0.094
Kenya-Nairobi 9861 1 0.015 0.013 0.008 0.722 0.014 0.055 0.006 0.168
Kenya-Nairobi 9862 2 0.018 0.004 0.126 0.571 0.174 0.068 0.005 0.035
Kenya-Nairobi 9863 1 0.005 0.005 0.105 0.459 0.262 0.005 0.011 0.148
Kenya-Nairobi 9864 2 0.028 0.042 0.016 0.512 0.35 0.022 0.003 0.026
Kenya-Nairobi 9865 4 0.012 0.027 0.008 0.643 0.166 0.029 0.069 0.046
Kenya-Nairobi 9866 3 0.028 0.008 0.108 0.629 0.041 0.076 0.016 0.093
Kenya-Nairobi 9867 0 0.023 0.021 0.009 0.58 0.302 0.009 0.029 0.027
Kenya-Nairobi 9868 5 0.048 0.018 0.126 0.571 0.047 0.13 0.005 0.055
Kenya-Pate 2000 2 0.043 0.005 0.003 0.018 0.009 0.014 0.006 0.902
Kenya-Pate 2001 3 0.002 0.003 0.002 0.001 0.002 0.001 0.002 0.987
Kenya-Pate 2002 1 0.002 0.009 0.002 0.001 0.002 0.002 0.007 0.975
Kenya-Pate 2003 0 0.002 0.004 0.003 0.003 0.006 0.004 0.024 0.953
Kenya-Pate 2004 3 0.013 0.008 0.016 0.004 0.034 0.033 0.011 0.881
Kenya-Pate 2006 3 0.006 0.049 0.002 0.004 0.007 0.003 0.11 0.82
Kenya-Pate 2007 4 0.005 0.005 0.002 0.005 0.005 0.006 0.007 0.965
Kenya-Pate 2009 6 0.03 0.005 0.003 0.012 0.005 0.023 0.003 0.918
Kenya-Pate 2011 3 0.012 0.003 0.008 0.005 0.092 0.01 0.006 0.864
Kenya-Lamu 1848 13 0.01 0.005 0.007 0.009 0.048 0.005 0.083 0.834
Kenya-Lamu 2014 4 0.038 0.055 0.006 0.019 0.01 0.01 0.004 0.859
Kenya-Lamu 2015 2 0.055 0.004 0.03 0.01 0.009 0.012 0.011 0.87
Kenya-Lamu 2016 2 0.014 0.005 0.043 0.006 0.008 0.008 0.005 0.91
Kenya-Lamu 2018 1 0.009 0.003 0.002 0.055 0.005 0.013 0.002 0.912
Kenya-Lamu 2019 2 0.054 0.005 0.018 0.023 0.04 0.069 0.005 0.785
Kenya-Lamu 2021 2 0.012 0.061 0.014 0.019 0.024 0.013 0.012 0.845
Kenya-Lamu 2023 3 0.002 0.002 0.002 0.002 0.002 0.002 0.003 0.983
Kenya-Lamu 2024 2 0.002 0.003 0.002 0.001 0.002 0.002 0.002 0.986
Kenya-Lamu 2025 3 0.004 0.008 0.002 0.003 0.003 0.003 0.007 0.971
Kenya-Lamu 2026 4 0.015 0.003 0.004 0.003 0.003 0.017 0.004 0.95
Kenya-Lamu 2027 6 0.007 0.018 0.012 0.029 0.034 0.006 0.053 0.841
Kenya-Lamu 2029 2 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.985
Kenya-Lamu 2030 1 0.01 0.006 0.002 0.01 0.047 0.005 0.003 0.918
Kenya-Lamu 2031 4 0.009 0.016 0.004 0.013 0.013 0.014 0.011 0.92
Kenya-Lamu 2032 2 0.01 0.035 0.004 0.004 0.006 0.008 0.007 0.926
Kenya-Lamu 2033 2 0.005 0.007 0.004 0.003 0.011 0.007 0.002 0.961
Kenya-Lamu 3241 4 0.016 0.007 0.004 0.016 0.059 0.033 0.029 0.836
Kenya-Lamu 3246 2 0.025 0.005 0.043 0.032 0.028 0.014 0.014 0.838
Kenya-Lamu 3247 3 0.035 0.005 0.023 0.089 0.02 0.007 0.01 0.812
India-Udaipur 11835 8 0.009 0.11 0.035 0.006 0.758 0.008 0.059 0.013
India-Udaipur 11836 3 0.008 0.125 0.002 0.007 0.831 0.006 0.014 0.006 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8 ndia-Udaipur 11837 2 0.006 0.226 0.01 0.002 0.651 0.007 0.024 0.075 ndia-Agra 11823 1 0.007 0.29 0.007 0.003 0.667 0.01 0.009 0.007 ndia-Agra 11824 2 0.03 0.157 0.002 0.004 0.72 0.012 0.004 0.071 ndia-Agra 11825 2 0.004 0.422 0.01 0.004 0.539 0.006 0.011 0.004 ndia-Agra 11826 6 0.004 0.297 0.005 0.002 0.671 0.003 0.014 0.003 ndia-Agra 11827 19 0.008 0.304 0.004 0.002 0.67 0.004 0.004 0.003 ndia-Agra 11828 2 0.346 0.091 0.004 0.003 0.52 0.009 0.007 0.018 ndia-Agra 11829 4 0.012 0.199 0.004 0.004 0.754 0.007 0.011 0.009 ndia-Agra 11830 8 0.006 0.312 0.003 0.002 0.665 0.003 0.005 0.003 ndia-Agra 11831 3 0.013 0.462 0.027 0.005 0.463 0.016 0.008 0.005 ndia-Agra 11832 2 0.003 0.417 0.004 0.002 0.56 0.004 0.006 0.004 ndia-Agra 11833 16 0.015 0.28 0.022 0.003 0.57 0.02 0.016 0.074 ndia-Agra 11834 3 0.004 0.342 0.006 0.002 0.627 0.004 0.012 0.003 ndia-Hyderbad 11802 13 0.016 0.005 0.01 0.008 0.826 0.119 0.01 0.005 ndia-Hyderbad 11803 7 0.018 0.023 0.004 0.003 0.928 0.008 0.005 0.012 ndia-Hyderbad 11804 5 0.004 0.029 0.005 0.002 0.678 0.003 0.264 0.014 ndia-Hyderbad 11805 10 0.011 0.009 0.01 0.005 0.926 0.015 0.009 0.014 ndia-Hyderbad 11807 11 0.006 0.008 0.022 0.005 0.936 0.008 0.007 0.008 ndia-Hyderbad 11808 9 0.016 0.003 0.036 0.016 0.834 0.008 0.061 0.026 ndia-Hyderbad 11809 3 0.067 0.032 0.007 0.101 0.773 0.011 0.003 0.006 ndia-Hyderbad 11810 0 0.01 0.045 0.017 0.005 0.697 0.082 0.062 0.081 ndia-Hyderbad 11811 0 0.009 0.004 0.003 0.009 0.757 0.011 0.009 0.198 ndia-Hyderbad 11812 3 0.007 0.086 0.013 0.002 0.859 0.005 0.015 0.014 ndia-Hyderbad 11813 4 0.023 0.016 0.126 0.003 0.793 0.007 0.029 0.004 ndia-Hyderbad 11814 2 0.006 0.019 0.009 0.003 0.938 0.01 0.004 0.01 ndia-Hyderbad 11815 2 0.011 0.024 0.053 0.005 0.844 0.027 0.007 0.029 ndia-Hyderbad 11816 3 0.007 0.016 0.002 0.003 0.952 0.006 0.005 0.009 ndia-Hyderbad 11817 2 0.003 0.005 0.035 0.002 0.941 0.005 0.004 0.005 ndia-Hyderbad 11818 1 0.008 0.007 0.107 0.069 0.76 0.014 0.005 0.03 ndia-Hyderbad 11819 4 0.009 0.016 0.002 0.003 0.948 0.008 0.005 0.009 ndia-Hyderbad 11820 5 0.003 0.022 0.009 0.002 0.865 0.007 0.048 0.044 ndia-Hyderbad 11821 13 0.021 0.01 0.192 0.006 0.662 0.057 0.014 0.037 ndia-Hyderbad 11822 2 0.015 0.012 0.009 0.004 0.902 0.008 0.037 0.014 ndia-Andhra 10159 2 0.007 0.006 0.01 0.008 0.919 0.014 0.032 0.003 ndia-Andhra 10160 1 0.002 0.003 0.008 0.002 0.752 0.004 0.225 0.004 ndia-Andhra 10161 2 0.004 0.006 0.021 0.006 0.948 0.004 0.005 0.007 ndia-Andhra 10162 5 0.004 0.004 0.016 0.003 0.964 0.003 0.004 0.003 ndia-Andhra 10163 0 0.004 0.007 0.009 0.004 0.937 0.003 0.018 0.017 ndia-Andhra 10164 2 0.006 0.02 0.012 0.007 0.917 0.005 0.03 0.003 ndia-Andhra 10165 1 0.006 0.01 0.073 0.004 0.87 0.007 0.004 0.026 ndia-Andhra 10166 3 0.025 0.006 0.08 0.013 0.71 0.009 0.008 0.15 ndia-Andhra 10167 1 0.013 0.003 0.064 0.013 0.85 0.036 0.012 0.009 ndia-Andhra 10168 1 0.008 0.007 0.027 0.006 0.922 0.02 0.006 0.003 ndia-Andhra 10169 6 0.004 0.003 0.112 0.008 0.848 0.012 0.007 0.006 ndia-Andhra 10170 4 0.037 0.004 0.146 0.007 0.702 0.036 0.045 0.022 ndia-Andhra 10171 1 0.006 0.021 0.013 0.006 0.91 0.004 0.036 0.003 ndia-Andhra 10172 2 0.007 0.02 0.017 0.012 0.916 0.006 0.01 0.013 ndia-Andhra 10173 2 0.005 0.003 0.321 0.004 0.648 0.008 0.003 0.009 ndia-Andhra 10174 3 0.003 0.002 0.021 0.004 0.958 0.004 0.006 0.002 ndia-Andhra 10175 2 0.009 0.005 0.007 0.044 0.891 0.019 0.018 0.006 ndia-Andhra 10176 2 0.013 0.011 0.005 0.005 0.885 0.008 0.071 0.003 ndia-Andhra 10177 0 0.008 0.006 0.016 0.09 0.833 0.005 0.034 0.008 ndia-Andhra 10178 3 0.003 0.005 0.024 0.004 0.953 0.003 0.005 0.004 ndia-Andhra 10179 4 0.005 0.004 0.018 0.016 0.901 0.006 0.007 0.044 ndia-Andhra 10180 10 0.029 0.015 0.017 0.026 0.849 0.051 0.009 0.004 ndia-Andhra 10181 5 0.004 0.003 0.023 0.004 0.898 0.005 0.057 0.006 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
India-Kolkata 10113 2 0.008 0.009 0.003 0.004 0.899 0.005 0.035 0.037
India-Kolkata 10114 1 0.005 0.006 0.026 0.003 0.942 0.004 0.009 0.006
India-Kolkata 10115 1 0.029 0.005 0.016 0.01 0.88 0.036 0.015 0.01
India-Kolkata 10116 2 0.004 0.006 0.022 0.002 0.941 0.003 0.015 0.008
India-Kolkata 10117 2 0.059 0.018 0.049 0.005 0.683 0.036 0.071 0.079
India-Kolkata 10118 3 0.009 0.025 0.09 0.012 0.558 0.267 0.018 0.021
India-Kolkata 10119 3 0.055 0.022 0.052 0.061 0.723 0.062 0.004 0.021
Sri Lanka 8780 1 0.025 0.007 0.006 0.088 0.767 0.011 0.079 0.018
Sri Lanka 8781 1 0.031 0.006 0.025 0.098 0.788 0.011 0.032 0.01
Sri Lanka 8782 3 0.024 0.005 0.006 0.056 0.852 0.035 0.011 0.011
Sri Lanka 8783 0 0.109 0.006 0.007 0.028 0.816 0.023 0.004 0.008
Sri Lanka 8784 1 0.017 0.007 0.072 0.25 0.607 0.007 0.033 0.008
Sri Lanka 8785 10 0.013 0.021 0.007 0.089 0.825 0.014 0.014 0.017
Sri Lanka 8786 0 0.188 0.025 0.013 0.046 0.625 0.024 0.031 0.048
Sri Lanka 8787 0 0.007 0.005 0.005 0.169 0.799 0.007 0.003 0.005
Sri Lanka 8788 4 0.058 0.082 0.026 0.069 0.724 0.028 0.004 0.009
Sri Lanka 8789 2 0.139 0.01 0.127 0.298 0.374 0.039 0.004 0.008
Sri Lanka 8790 1 0.015 0.003 0.07 0.184 0.718 0.005 0.003 0.002
Sri Lanka 8791 1 0.03 0.01 0.021 0.017 0.892 0.01 0.007 0.013
Sri Lanka 8792 0 0.05 0.011 0.005 0.042 0.855 0.026 0.004 0.007
Sri Lanka 8793 2 0.042 0.016 0.008 0.215 0.685 0.009 0.004 0.02
Sri Lanka 8794 2 0.033 0.019 0.005 0.173 0.742 0.018 0.007 0.004
Sri Lanka 8795 1 0.042 0.005 0.016 0.161 0.709 0.033 0.014 0.02
Sri Lanka 8796 4 0.068 0.004 0.007 0.021 0.746 0.034 0.111 0.009
Sri Lanka 8797 1 0.011 0.061 0.031 0.325 0.545 0.005 0.013 0.009
Sri Lanka 8798 1 0.107 0.011 0.005 0.061 0.763 0.028 0.022 0.003
Sri Lanka 8799 2 0.003 0.008 0.009 0.263 0.664 0.004 0.002 0.047
Sri Lanka 8800 2 0.014 0.01 0.068 0.37 0.465 0.011 0.041 0.02
Sri Lanka 8801 5 0.011 0.019 0.004 0.201 0.709 0.007 0.004 0.044
Sri Lanka 8802 2 0.006 0.007 0.024 0.4 0.54 0.004 0.004 0.015
Sri Lanka 8803 6 0.036 0.005 0.103 0.055 0.7 0.019 0.015 0.067
Thailand 11688 6 0.002 0.001 0.984 0.003 0.003 0.002 0.002 0.003
Thailand 11689 13 0.003 0.022 0.937 0.004 0.009 0.008 0.014 0.003
Thailand 11691 27 0.012 0.007 0.909 0.018 0.026 0.009 0.014 0.005
Thailand 11698 18 0.005 0.003 0.937 0.007 0.014 0.007 0.026 0.002
Thailand 11702 10 0.002 0.002 0.973 0.003 0.008 0.003 0.005 0.003
Thailand 11703 12 0.002 0.002 0.983 0.002 0.004 0.002 0.004 0.002
Thailand 11705 21 0.035 0.009 0.824 0.003 0.104 0.008 0.01 0.007
Thailand 11707 4 0.004 0.002 0.976 0.003 0.006 0.003 0.004 0.003
Thailand 11708 18 0.006 0.003 0.954 0.003 0.005 0.007 0.009 0.013
Thailand 11709 12 0.003 0.003 0.979 0.002 0.005 0.003 0.003 0.004
Thailand 11710 9 0.006 0.004 0.959 0.006 0.007 0.007 0.006 0.003
Thailand 11711 6 0.002 0.006 0.948 0.004 0.008 0.003 0.024 0.006
Thailand 11714 6 0.008 0.01 0.95 0.004 0.011 0.003 0.008 0.006
Thailand 11715 17 0.009 0.089 0.753 0.006 0.094 0.004 0.035 0.009
Thailand 11717 15 0.003 0.005 0.969 0.003 0.008 0.003 0.006 0.003
Thailand 11718 2 0.004 0.005 0.969 0.004 0.003 0.006 0.007 0.003
Thailand 11720 4 0.001 0.001 0.99 0.001 0.002 0.001 0.001 0.001
Vietnam 8844 4 0.008 0.01 0.806 0.007 0.123 0.004 0.035 0.008
Vietnam 8845 3 0.02 0.079 0.748 0.007 0.099 0.026 0.01 0.01
Vietnam 8846 3 0.022 0.003 0.65 0.014 0.265 0.038 0.004 0.005
Vietnam 8847 10 0.005 0.004 0.966 0.01 0.005 0.003 0.005 0.003
Vietnam 8848 6 0.03 0.006 0.883 0.01 0.031 0.015 0.004 0.02
Vietnam 8849 2 0.032 0.007 0.829 0.01 0.024 0.067 0.028 0.003
Vietnam 8850 1 0.114 0.007 0.659 0.149 0.01 0.009 0.042 0.009
Vietnam 8851 2 0.03 0.126 0.767 0.012 0.015 0.043 0.004 0.002 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Vietnam 8852 13 0.201 0.004 0.701 0.025 0.018 0.024 0.009 0.017
Vietnam 8853 3 0.32 0.004 0.601 0.012 0.027 0.027 0.005 0.005
Vietnam 8854 5 0.056 0.163 0.636 0.037 0.069 0.008 0.028 0.004
Vietnam 8855 2 0.029 0.003 0.743 0.134 0.009 0.045 0.033 0.003
Vietnam 8856 2 0.077 0.005 0.693 0.005 0.13 0.085 0.004 0.002
Vietnam 8857 3 0.016 0.006 0.472 0.015 0.442 0.035 0.005 0.008
Vietnam 8858 2 0.077 0.005 0.709 0.06 0.017 0.112 0.015 0.004
Vietnam 8859 7 0.048 0.014 0.658 0.015 0.069 0.015 0.147 0.035
Vietnam 8860 2 0.19 0.01 0.619 0.011 0.009 0.083 0.055 0.023
Vietnam 8861 2 0.245 0.026 0.576 0.01 0.07 0.021 0.044 0.009
Vietnam 8862 2 0.04 0.009 0.44 0.02 0.39 0.023 0.04 0.039
Vietnam 8863 3 0.093 0.012 0.613 0.048 0.015 0.197 0.015 0.006
Taiwan 8681 4 0.005 0.005 0.014 0.654 0.004 0.004 0.309 0.005
Taiwan 8682 0 0.011 0.034 0.381 0.01 0.105 0.008 0.443 0.007
Taiwan 8683 3 0.058 0.023 0.103 0.119 0.086 0.04 0.562 0.009
Taiwan 8684 3 0.007 0.008 0.06 0.65 0.005 0.006 0.261 0.003
Taiwan 8685 2 0.012 0.003 0.352 0.037 0.035 0.007 0.544 0.01
Taiwan 8686 6 0.035 0.008 0.19 0.258 0.014 0.007 0.464 0.024
Taiwan 8687 5 0.087 0.028 0.44 0.011 0.044 0.054 0.329 0.007
Taiwan 8688 26 0.016 0.014 0.288 0.03 0.111 0.013 0.499 0.028
Taiwan 8689 5 0.039 0.15 0.143 0.035 0.009 0.014 0.525 0.086
Taiwan 8690 2 0.012 0.067 0.312 0.009 0.036 0.005 0.553 0.006
Taiwan 8691 16 0.023 0.008 0.324 0.046 0.111 0.019 0.436 0.033
Taiwan 8692 3 0.014 0.009 0.478 0.025 0.01 0.006 0.45 0.009
Taiwan 8693 2 0.018 0.007 0.212 0.105 0.092 0.008 0.547 0.01
Taiwan 8694 1 0.005 0.004 0.443 0.437 0.017 0.004 0.087 0.003
Taiwan 8695 1 0.019 0.003 0.21 0.056 0.009 0.064 0.629 0.011
Taiwan 8696 11 0.004 0.002 0.003 0.972 0.004 0.004 0.009 0.003
Taiwan 8697 1 0.025 0.011 0.005 0.898 0.02 0.008 0.029 0.005
Taiwan 8698 4 0.003 0.002 0.002 0.981 0.002 0.003 0.004 0.002
Taiwan 8699 6 0.036 0.081 0.04 0.045 0.507 0.05 0.231 0.011
Taiwan 8700 2 0.087 0.014 0.278 0.213 0.025 0.022 0.355 0.006
Taiwan 8701 2 0.004 0.005 0.159 0.205 0.045 0.005 0.574 0.004
Taiwan 8702 2 0.059 0.011 0.182 0.238 0.018 0.024 0.448 0.021
Taiwan 8703 2 0.005 0.004 0.008 0.94 0.012 0.017 0.009 0.005
Taiwan 8704 1 0.086 0.003 0.263 0.007 0.007 0.018 0.574 0.042
Taiwan 8705 2 0.01 0.015 0.268 0.008 0.082 0.026 0.572 0.019
Taiwan 8706 2 0.061 0.026 0.208 0.045 0.049 0.062 0.523 0.026
Taiwan 8707 5 0.004 0.088 0.29 0.017 0.035 0.026 0.536 0.004
Taiwan 8708 3 0.004 0.003 0.007 0.967 0.005 0.003 0.006 0.005
Taiwan 8709 4 0.024 0.011 0.285 0.014 0.015 0.009 0.63 0.013
Japan-Oita 11967 2 0.039 0.025 0.004 0.01 0.019 0.04 0.857 0.005
Japan-Oita 11968 1 0.004 0.006 0.004 0.002 0.007 0.002 0.972 0.003
Japan-Oita 11969 1 0.006 0.053 0.003 0.004 0.009 0.008 0.892 0.025
Japan-Oita 11970 1 0.004 0.01 0.031 0.008 0.036 0.01 0.894 0.006
Japan-Oita 11971 2 0.009 0.008 0.004 0.003 0.006 0.006 0.961 0.003
Japan-Oita 11972 8 0.004 0.073 0.012 0.002 0.075 0.007 0.819 0.008
Japan-Oita 11973 2 0.002 0.001 0.002 0.001 0.002 0.002 0.987 0.003
Japan-Oita 11974 1 0.002 0.002 0.004 0.002 0.002 0.002 0.983 0.003
Japan-Oita 11975 2 0.007 0.009 0.002 0.008 0.04 0.008 0.914 0.012
Japan-Oita 11976 3 0.006 0.003 0.002 0.002 0.003 0.006 0.975 0.005
Japan-Oita 11977 2 0.003 0.007 0.016 0.002 0.024 0.003 0.939 0.006
Japan-Oita 11979 2 0.005 0.009 0.002 0.015 0.005 0.006 0.948 0.012
Japan-Oita 11980 2 0.017 0.03 0.003 0.002 0.007 0.023 0.908 0.007
Japan-Oita 11981 2 0.016 0.01 0.004 0.012 0.042 0.014 0.889 0.012
Japan-Oita 11982 0 0.005 0.021 0.013 0.004 0.006 0.003 0.944 0.004 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
Japan-Oita 11985 0 0.003 0.023 0.003 0.002 0.014 0.005 0.928 0.022
Japan-Oita 11986 1 0.008 0.008 0.003 0.006 0.005 0.009 0.952 0.009
Japan-Kanazawa 11929 1 0.005 0.011 0.003 0.002 0.003 0.005 0.967 0.005
Japan-Kanazawa 11931 1 0.01 0.054 0.007 0.005 0.013 0.012 0.889 0.01
Japan-Kanazawa 11932 1 0.005 0.007 0.003 0.006 0.018 0.006 0.952 0.002
Japan-Kanazawa 11933 4 0.005 0.006 0.006 0.003 0.004 0.006 0.968 0.002
Japan-Kanazawa 11934 19 0.003 0.003 0.009 0.003 0.012 0.003 0.961 0.007
Japan-Kanazawa 11936 9 0.012 0.009 0.017 0.007 0.01 0.005 0.933 0.007
Japan-Kanazawa 11937 23 0.016 0.004 0.016 0.005 0.087 0.007 0.856 0.008
Japan-Kanazawa 11939 1 0.005 0.009 0.038 0.004 0.007 0.004 0.919 0.016
Japan-Kanazawa 11940 2 0.005 0.006 0.007 0.002 0.013 0.003 0.959 0.004
Japan-Kanazawa 11941 1 0.011 0.084 0.01 0.004 0.007 0.006 0.863 0.015
Japan-Kanazawa 11942 2 0.004 0.001 0.014 0.005 0.003 0.004 0.967 0.001
Japan-Kanazawa 11943 1 0.032 0.004 0.004 0.023 0.005 0.01 0.921 0.003
Japan-Kanazawa 11944 0 0.005 0.003 0.009 0.003 0.017 0.005 0.943 0.015
Japan-Kanazawa 11945 1 0.066 0.014 0.006 0.005 0.004 0.013 0.891 0.003
Japan-Kanazawa 11946 1 0.203 0.014 0.004 0.03 0.008 0.006 0.721 0.015
Japan-Ohmiya 11947 3 0.005 0.003 0.007 0.003 0.004 0.003 0.972 0.002
Japan-Ohmiya 11948 3 0.011 0.005 0.006 0.052 0.01 0.015 0.896 0.006
Japan-Ohmiya 11951 14 0.02 0.087 0.003 0.572 0.015 0.022 0.278 0.003
Japan-Ohmiya 11953 1 0.007 0.005 0.004 0.016 0.005 0.004 0.953 0.005
Japan-Ohmiya 11954 2 0.005 0.004 0.003 0.004 0.003 0.006 0.971 0.003
Japan-Ohmiya 11955 8 0.013 0.004 0.002 0.123 0.005 0.01 0.837 0.006
Japan-Ohmiya 11956 4 0.03 0.007 0.007 0.007 0.007 0.059 0.882 0.002
Japan-Ohmiya 11957 1 0.004 0.002 0.012 0.002 0.01 0.005 0.963 0.003
Japan-Ohmiya 11959 2 0.002 0.004 0.003 0.002 0.008 0.002 0.973 0.006
Japan-Ohmiya 11960 2 0.065 0.028 0.007 0.392 0.024 0.04 0.433 0.011
Japan-Ohmiya 11961 8 0.018 0.006 0.047 0.015 0.059 0.016 0.806 0.033
Japan-Ohmiya 11962 3 0.01 0.004 0.003 0.02 0.004 0.009 0.944 0.005
Japan-Ohmiya 11963 5 0.01 0.003 0.309 0.085 0.005 0.026 0.523 0.039
Japan-Ohmiya 11964 11 0.006 0.002 0.139 0.447 0.003 0.005 0.385 0.013
Japan-Ohmiya 11965 2 0.003 0.008 0.002 0.003 0.003 0.002 0.973 0.005
Japan-Ohmiya 11966 2 0.019 0.004 0.006 0.01 0.046 0.022 0.885 0.008
Japan-Sapporo 11907 3 0.009 0.005 0.04 0.004 0.015 0.005 0.912 0.009
Japan-Sapporo 11909 1 0.024 0.014 0.007 0.011 0.131 0.013 0.792 0.009
Japan-Sapporo 11911 0 0.07 0.007 0.024 0.019 0.021 0.013 0.75 0.096
Japan-Sapporo 11913 2 0.004 0.003 0.024 0.002 0.007 0.003 0.952 0.006
Japan-Sapporo 11914 9 0.11 0.007 0.003 0.051 0.003 0.055 0.739 0.031
Japan-Sapporo 11915 2 0.005 0.006 0.002 0.003 0.003 0.003 0.977 0.002
Japan-Sapporo 11916 3 0.011 0.023 0.007 0.016 0.009 0.007 0.915 0.012
Japan-Sapporo 11917 6 0.046 0.007 0.349 0.006 0.011 0.122 0.455 0.004
Japan-Sapporo 11918 2 0.041 0.006 0.024 0.009 0.006 0.013 0.897 0.003
Japan-Sapporo 11921 6 0.016 0.012 0.017 0.005 0.025 0.008 0.915 0.003
Japan-Sapporo 11922 4 0.02 0.006 0.369 0.008 0.009 0.011 0.567 0.011
Japan-Sapporo 11923 5 0.021 0.004 0.425 0.164 0.021 0.04 0.307 0.018
Japan-Sapporo 11924 5 0.008 0.005 0.347 0.051 0.005 0.077 0.501 0.006
Japan-Sapporo 11925 15 0.039 0.01 0.591 0.01 0.011 0.101 0.233 0.005
Japan-Sapporo 11926 8 0.027 0.015 0.406 0.017 0.045 0.01 0.47 0.01
China-Henan 8869 3 0.018 0.004 0.257 0.009 0.037 0.007 0.661 0.007
China-Henan 8870 3 0.005 0.007 0.105 0.263 0.01 0.005 0.595 0.011
China-Henan 8871 20 0.011 0.006 0.314 0.007 0.073 0.013 0.56 0.017
China-Henan 8872 19 0.022 0.002 0.432 0.131 0.119 0.013 0.276 0.005
China-Henan 8873 16 0.016 0.005 0.418 0.138 0.014 0.008 0.399 0.003
China-Henan 8874 5 0.014 0.007 0.535 0.03 0.005 0.006 0.394 0.008
China-Henan 8875 11 0.007 0.007 0.435 0.012 0.006 0.011 0.512 0.01
China-Henan 8876 18 0.006 0.007 0.4 0.007 0.011 0.008 0.545 0.017 Table 25 - Population clustering of each random bred individual in the database by
SNPs and STRs at K = 8
Sampling ID Missing Population
Location No. Data 1 2 3 4 5 6 7 8
China-Henan 8877 16 0.002 0.003 0.317 0.002 0.004 0.002 0.665 0.005
China-Henan 8878 6 0.023 0.005 0.399 0.025 0.014 0.004 0.525 0.006
China-Henan 8879 11 0.01 0.004 0.338 0.006 0.028 0.018 0.594 0.003
China-Henan 8880 7 0.017 0.005 0.249 0.273 0.01 0.03 0.412 0.004
China-Henan 8881 7 0.003 0.003 0.001 0.981 0.003 0.003 0.003 0.003
China-Henan 8882 18 0.003 0.007 0.163 0.04 0.045 0.005 0.729 0.007
China-Henan 8883 6 0.006 0.006 0.111 0.205 0.028 0.005 0.634 0.004
China-Henan 8884 14 0.004 0.002 0.118 0.021 0.013 0.009 0.667 0.166
China-Henan 8885 4 0.004 0.001 0.09 0.156 0.004 0.003 0.737 0.005
China-Henan 8886 8 0.007 0.003 0.429 0.014 0.01 0.007 0.527 0.003
China-Henan 8887 23 0.007 0.005 0.013 0.025 0.01 0.004 0.933 0.004
China-Henan 8888 18 0.004 0.004 0.324 0.007 0.013 0.003 0.639 0.006
South Korea 2769 12 0.005 0.007 0.136 0.006 0.009 0.006 0.823 0.008
South Korea 2772 7 0.009 0.012 0.218 0.007 0.01 0.008 0.734 0.003
South Korea 2775 9 0.003 0.003 0.077 0.005 0.048 0.005 0.836 0.022
South Korea 2776 19 0.015 0.026 0.379 0.011 0.095 0.014 0.45 0.009
South Korea 2779 13 0.029 0.013 0.079 0.708 0.026 0.086 0.006 0.052
South Korea 2784 16 0.005 0.005 0.264 0.038 0.011 0.005 0.656 0.015
South Korea 2785 15 0.002 0.002 0.043 0.004 0.006 0.014 0.923 0.006
South Korea 2786 4 0.023 0.004 0.144 0.083 0.011 0.06 0.672 0.004
South Korea 7671 16 0.032 0.029 0.009 0.017 0.011 0.019 0.861 0.021
South Korea 7672 18 0.008 0.025 0.05 0.064 0.119 0.06 0.653 0.022
South Korea 7673 3 0.005 0.003 0.294 0.003 0.004 0.004 0.684 0.002
South Korea 7674 3 0.008 0.009 0.217 0.198 0.019 0.008 0.538 0.003
South Korea 7675 5 0.004 0.003 0.096 0.273 0.008 0.006 0.581 0.029
South Korea 7676 3 0.007 0.004 0.519 0.005 0.01 0.009 0.439 0.007
South Korea 7677 3 0.05 0.007 0.016 0.102 0.009 0.03 0.724 0.063
South Korea 7678 6 0.018 0.003 0.034 0.039 0.009 0.091 0.797 0.009
South Korea 7679 3 0.002 0.004 0.465 0.004 0.004 0.002 0.517 0.002
South Korea 7680 3 0.013 0.004 0.072 0.005 0.011 0.009 0.88 0.006
South Korea 7681 5 0.009 0.005 0.221 0.157 0.06 0.012 0.521 0.014
South Korea 7682 3 0.012 0.007 0.147 0.11 0.042 0.005 0.656 0.021
South Korea 7683 4 0.01 0.018 0.059 0.157 0.115 0.006 0.614 0.021
South Korea 7684 4 0.008 0.003 0.12 0.006 0.084 0.013 0.602 0.163
South Korea 7685 4 0.012 0.011 0.149 0.104 0.048 0.028 0.637 0.012
South Korea 7686 6 0.014 0.014 0.204 0.02 0.016 0.008 0.716 0.01
South Korea 7687 9 0.005 0.003 0.005 0.971 0.005 0.003 0.005 0.003
South Korea 7688 15 0.014 0.008 0.033 0.403 0.013 0.003 0.522 0.004
South Korea 7689 14 0.013 0.003 0.166 0.291 0.014 0.008 0.496 0.009
South Korea 7690 6 0.014 0.005 0.198 0.174 0.075 0.007 0.521 0.005
South Korea 7691 8 0.004 0.009 0.664 0.009 0.009 0.016 0.286 0.003
South Korea 7692 6 0.034 0.002 0.013 0.896 0.018 0.028 0.006 0.003
South Korea 7693 4 0.012 0.01 0.003 0.892 0.006 0.009 0.023 0.045
South Korea 7694 12 0.013 0.01 0.179 0.223 0.087 0.02 0.448 0.02
South Korea 7695 5 0.006 0.009 0.316 0.003 0.035 0.006 0.602 0.022
South Korea 7696 5 0.006 0.004 0.073 0.016 0.226 0.004 0.642 0.028
South Korea 7697 7 0.012 0.003 0.352 0.016 0.025 0.005 0.568 0.019
South Korea 7698 5 0.038 0.005 0.341 0.557 0.009 0.006 0.037 0.007
South Korea 7699 9 0.004 0.003 0.583 0.002 0.014 0.004 0.379 0.011
South Korea 7700 10 0.031 0.008 0.025 0.288 0.016 0.108 0.52 0.003 [0183] It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and scope of the appended claims. All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes.

Claims

CLAIMS What is claimed is:
1. A computer implemented method for determining the contributions of feline populations to a feline genome, comprising:
(a) genotyping a sample comprising genomic DNA obtained from a test feline to determine the identity of one or both alleles of each marker of a set of markers, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ;
(b) comparing the identity of one or both alleles for each of the markers in the set of markers determined to be present in the test feline genome to a database comprising one or more feline population profiles, wherein each feline population profile comprises genotype information for the set of markers in the feline population; and
(c) determining the contribution of the one or more feline populations to the test feline genome.
2. The method of claim 1 , wherein the plurality of SNPs comprises at least about 100 SNPs listed in Table 1.
3. The method of claim 1 , wherein the plurality of SNPs comprises all 148 SNPs listed in Table 1.
4. The method of any one of claims 1 to 3, wherein the set of markers further comprises one or more microsatellite markers.
5. The method of claim 4, wherein the set of markers further comprises one or more short tandem repeats (STRs) selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
6. The method of any one of claims 1 to 5, wherein the set of markers further comprises one or more phenotypic markers.
7. The method of claim 6, wherein the one or more phenotypic markers are selected from the group consisting of Phen_CMAH_G139A, Phen ASIP del,
Phen_MLPH_T83del, Phen_MClR_G250A, Phen_TYRPl_C298T, Phen_TYRPl_5IVS6, Phen_TYR_del975C, Phen_TYR_G715T, Phen_TYR_G940A, Phen_KIT_G1035C_BI, Phen_FGF5_475, Phen_FGF5_474, phen_FGF5_406, Phen_FGF5_356,
Phen_GBLl_G1457C_SIA_KOR, Phen HEXB Dellntr BUR,
Phen_HEXB_del39C_KOR, Phen GBE l lns NFC, Phen_KRT7 l_G/Aintro4_SPX, Phen_MYBPC_G93C_MCC, Phen_MYBPC_C2460T_RAG, phen MPO ALC,
Phen PLAU AG ALC, Phen FCAT ALC, Phen_PKLR_13delE6_Aby,
Phen PKD 1_C 10063 A PER, Phen_SHH_A479G_Hw, Phen_CEP290_PRA_Aby, Phen_CRX_546_Aby, Phen CMAH del, Phen_HEXB_C667T_DSH,
Phen_GM2A_Del_DSH, Phen GRHPR DSH, Phen_LPL_G1234A_DSH,
Phen LAMAN del PER, Phen lDUA del DSH, Phen_ARSB_G1558A_SIA,
Phen ARSB T 1427C_Sia, Phen GUSB A 1052G DSH, Phen_MYBPC_A74T_Poly, Phen_NPCl_G2864C_PER, Phen_SHH_G257C_UKl, Phen_SHH_A481T_UK2, Phen_HMBS_del842_SIA, Phen-HMBS_189TT_SIA, Phen_CYP21Bl,
Phen TAS 1 R2 CAT, Phen_TASlR2_G8224A_CAT, Phen_CYP27Bl_Rob, Phen ZFX, KRT71 -Del Drex, P2RY5_CRex, WNK4_Burm_HKL and CARTl del Burm.
8. The method of any one of claims 1 to 7, wherein the genotype information in each feline population profile comprises identities of one or both alleles of each marker of the set of markers.
9. The method of any one of claims 1 to 8, wherein the genotype information in each feline population profile comprises allele frequencies for one or both alleles of each marker of the set of markers.
10. The method of any one of claims 1 to 9, wherein the database of feline population profiles comprises a plurality of feline population profiles.
11. The method of any one of claims 1 to 10, wherein the database of feline populations profiles comprises profiles for at least one feline breed.
12. The method of any one of claims 1 to 11, wherein the set of markers comprises a subset of the 148 SNP markers listed in Table 1 and wherein the method determines the contributions of one or more feline populations to the test feline genome.
13. The method of any one of claims 1 to 12, wherein step (a) comprises amplifying genomic DNA of the test feline using primers specific for each of the set of markers and determining the size of the amplification product.
14. The method of any one of claims 1 to 12, wherein step (a) comprises amplifying genomic DNA of the test feline using primers specific for each of the set of markers and sequencing the amplification product.
15. The method of any one of claims 1 to 14, wherein the algorithm according to step (b) comprises a genotype clustering program.
16. The method of any one of claims 1 to 15, wherein the algorithm according to step (b) comprises an assignment algorithm.
17. The method of any one of claims 1 to 16, wherein step (b) comprises discriminating between the contributions of two or more genetically related feline populations to the test feline genome by comparing the alleles in the test feline genome to a database comprising profiles of the two or more genetically related feline populations.
18. The method of claim 17, wherein the two or more genetically related feline populations are selected from the group consisting of:
(i) Persian and Exotic Shorthair (SH);
(ii) British SH and Scottish Fold;
(iii) Australian Mist and Burmese;
(iv) Singapura and Burmese;
(v) Birman and Korat; and
(vi) Siamese and Havana Brown.
19. The method of any one of claims 1 to 18, further comprising the step of providing a document displaying the contributions of one or more feline populations to the genome of the test feline genome.
20. The method of claim 19, wherein the document provides additional information regarding the one or more feline populations that contributed to the genome of the test feline.
21. The method of claim 20, wherein the additional information is health- related information.
22. The method of claim 20, wherein the document provides a certification of the contributions of one or more feline populations to the genome of the test feline.
23. The method of claim 20, wherein the document provides a representation of the one or more feline populations that contributed to the genome of the test feline.
24. A method for defining one or more feline populations, comprising: (a) determining the identity of one or both alleles for each marker of a set of markers in a test feline genome, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
(b) applying a computer-implemented statistical model to define one or more distinct feline populations, wherein one or more distinct feline populations are characterized by a set of allele frequencies for each marker in the set of markers comprising a plurality of SNPs listed in Table 1.
25. One or more computer-readable media comprising:
(a) a data structure stored thereon for use in distinguishing feline populations, the data structure comprising:
(i) marker data, wherein the marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1; and
(ii) genotype information data, wherein the genotype information data provides genotype information for each marker of a set of markers in a feline population, wherein a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile; and
(b) computer-executable instructions for controlling one or more computing devices to:
(i) identify one or both alleles in a test feline genome for each marker of the set of markers; and (ii) determine the contributions of one or more feline populations to the test feline genome by comparing the identified alleles in the test feline genome to the database comprising one or more feline population profiles, wherein each feline population profile comprises genotype information for the set of markers in the feline population.
26. One or more computer-readable media comprising a data structure stored thereon for use in distinguishing feline populations, the data structure comprising:
(a) marker data, wherein the marker data identifies one or both alleles of each marker of a set of markers in one or more feline population profiles, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1 ; and
(b) genotype information data, wherein the genotype information data provides genotype information for each marker of a set of markers in a feline population, wherein a record comprises an instantiation of the marker data and an instantiation of the genotype information data and a set of records represents a feline population profile.
27. The computer readable media of any one of claims 25 to 26, wherein the plurality of SNPs comprises at least about 100 SNPs listed in Table 1.
28. The computer readable media of any one of claims 25 to 26, wherein the plurality of SNPs comprises all 148 SNPs listed in Table 1.
29. The computer readable media of any one of claims 25 to 28, wherein the set of markers further comprises one or more microsatellite markers.
30. The computer readable media of claim 29, wherein the set of markers further comprises one or more short tandem repeats (STRs) selected from the group consisting of FCA005, FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
31. The computer readable media of any one of claims 25 to 30, wherein the set of markers further comprises one or more phenotypic markers.
32. The computer readable media of claim 31 , wherein the one or more phenotypic markers are selected from the group consisting of Phen_CMAH_G139A, Phen ASIP del, Phen_MLPH_T83del, Phen_MClR_G250A, Phen_TYRPl_C298T, Phen_TYRPl_5IVS6, Phen_TYR_del975C, Phen_TYR_G715T, Phen_TYR_G940A, Phen_KIT_G1035C_BI, Phen_FGF5_475, Phen_FGF5_474, phen_FGF5_406,
Phen_FGF5_356, Phen_GBLl_G1457C_SIA_KOR, Phen HEXB Dellntr BUR,
Phen_HEXB_del39C_KOR, Phen GBE l lns NFC, Phen_KRT7 l_G/Aintro4_SPX, Phen_MYBPC_G93C_MCC, Phen_MYBPC_C2460T_RAG, phen MPO ALC,
Phen PLAU AG ALC, Phen FCAT ALC, Phen_PKLR_13delE6_Aby,
Phen PKD 1_C 10063 A PER, Phen_SHH_A479G_Hw, Phen_CEP290_PRA_Aby, Phen_CRX_546_Aby, Phen CMAH del, Phen_HEXB_C667T_DSH,
Phen_GM2A_Del_DSH, Phen GRHPR DSH, Phen_LPL_G1234A_DSH,
Phen LAMAN del PER, Phen lDUA del DSH, Phen_ARSB_G1558A_SIA,
Phen ARSB T 1427C_Sia, Phen GUSB A 1052G DSH, Phen_MYBPC_A74T_Poly, Phen_NPCl_G2864C_PER, Phen_SHH_G257C_UKl, Phen_SHH_A481T_UK2,
Phen_HMBS_del842_SIA, Phen-HMBS_189TT_SIA, Phen_CYP21Bl,
Phen TAS 1 R2 CAT, Phen_TASlR2_G8224A_CAT, Phen_CYP27Bl_Rob, Phen ZFX, KRT71 -Del Drex, P2RY5_CRex, WNK4_Burm_HKL and CARTl del Burm.
33. A method for determining the contributions of feline populations to a feline genome, comprising performing a genotyping assay on a sample comprising genomic
DNA obtained from a test feline to determine the identity of one or both alleles present in the test feline genome for each marker of a set of markers, wherein the set of markers is indicative of the contribution of feline populations to the genome of the test feline, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1.
34. A method of assigning a feline individual to a population of origin, which comprises:
(a) genotyping the feline individual to identify one or both alleles of each marker of a set of markers to thereby identify the individual's genotype, wherein the set of markers comprises a plurality of single nucleotide polymorphisms (SNPs) listed in Table 1;
(b) applying a computer-implemented statistical model to assign the feline individual to one or more feline populations in a database, wherein the one or more feline populations are characterized by a set of allele frequencies for each marker in the set of markers; and
(c) assigning the feline individual to the one or more most likely populations identified in step (b).
35. The method of claim 34, wherein the individual is assigned to the one or more most likely feline populations if the population genotype probability for the most likely feline populations exceed the value of assignment to any other feline populations of the database.
36. The method of any one of claims 34 to 35, wherein the set of markers further comprises one or more STRs selected from the group consisting of FCA005,
FCA008, FCA023, FCA026, FCA035, FCA043, FCA045, FCA058, FCA069, FCA075, FCA077, FCA080B, FCA088, FCA090, FCA094, FCA096, FCA097, FCA105, FCA123, FCA126, FCA132, FCA149, FCA211, FCA220, FCA223, FCA224, FCA229, FCA262, FCA293, FCA305, FCA310, FCA391, FCA441, FCA453, FCA628, FCA649, FCA678 and FCA698.
37. The method of any one of claims 34 to 36, wherein the set of markers further comprises one or more of the phenotypic markers selected from the group consisting of Phen CMAH G 139 A, Phen ASIP del, Phen_MLPH_T83del, Phen_MClR_G250A, Phen_TYRPl_C298T, Phen_TYRPl_5IVS6, Phen_TYR_del975C, Phen_TYR_G715T, Phen_TYR_G940A, Phen_KIT_G1035C_BI, Phen_FGF5_475, Phen_FGF5_474, phen_FGF5_406, Phen_FGF5_356, Phen_GBLl_G1457C_SIA_KOR,
Phen HEXB Dellntr BUR, Phen_HEXB_del39C_KOR, Phen GBE 1 Ins NFC ,
Phen_KRT7 l_G/Aintro4_SPX, Phen_MYBPC_G93C_MCC,
Phen_MYBPC_C2460T_RAG, phen MPO ALC, Phen PLAU AG ALC,
Phen FC AT ALC , Phen PKLR l 3delE6_Aby, Phen PKD 1_C 10063 A PER,
Phen_SHH_A479G_Hw, Phen_CEP290_PRA_Aby, Phen_CRX_546_Aby,
Phen CMAH del, Phen_HEXB_C667T_DSH, Phen_GM2A_Del_DSH,
Phen GRHPR DSH, Phen_LPL_G1234A_DSH, Phen LAMAN del PER,
Phen lDUA del DSH, Phen_ARSB_G1558A_SIA, Phen_ARSB_T1427C_Sia,
Phen GUSB Al 052G DSH, Phen_MYBPC_A74T_Poly, Phen NPC 1 G2864C PER, Phen_SHH_G257C_UKl, Phen_SHH_A481T_UK2, Phen_HMBS_del842_SIA, Phen- HMBS l 89TT SIA, Phen_CYP21Bl, Phen TAS 1 R2 CAT, Phen_TASlR2_G8224A_CAT, Phen_CYP27Bl_Rob, Phen ZFX, KRT71 -Del Drex, P2RY5 CRex, WNK4_Burm_HKL and CARTl del Burm.
38. The method of any one of claims 34 to 37, wherein prior to genotyping, a most likely population of origin is based on one or more morphological features of the individual.
39. The method of any one of claims 34 to 37, wherein prior to genotyping, one or more morphological features of the individual allow the exclusion of one or more of the candidate populations of origin.
40. The method of any one of claims 34 to 39, wherein marker locus genotypes for said each candidate population are in Hardy- Weinberg Equilibrium and Gametic Phase Equilibrium.
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