WO2012158197A3 - Compounds useful as akt/pkb modulators and uses thereof - Google Patents

Compounds useful as akt/pkb modulators and uses thereof Download PDF

Info

Publication number
WO2012158197A3
WO2012158197A3 PCT/US2011/060467 US2011060467W WO2012158197A3 WO 2012158197 A3 WO2012158197 A3 WO 2012158197A3 US 2011060467 W US2011060467 W US 2011060467W WO 2012158197 A3 WO2012158197 A3 WO 2012158197A3
Authority
WO
WIPO (PCT)
Prior art keywords
akt
compounds useful
pkb
modulators
compounds
Prior art date
Application number
PCT/US2011/060467
Other languages
French (fr)
Other versions
WO2012158197A2 (en
Inventor
Lawrence Akinsanmi
John Kincaid
Original Assignee
Lyndor Biosciences L.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyndor Biosciences L.L.C. filed Critical Lyndor Biosciences L.L.C.
Publication of WO2012158197A2 publication Critical patent/WO2012158197A2/en
Publication of WO2012158197A3 publication Critical patent/WO2012158197A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds, and pharmaceutical compositions, and formulations thereof, are disclosed that have formula (I): where R1a, R1b, R1c, R2, R3, R6a, R6b, R6c, R7, and R8 are as defined herein. The compounds, pharmaceutical compositions, and pharmaceutical formulations thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others. The manufacturing and analytical methods for LD- 101 are also disclosed.
PCT/US2011/060467 2010-11-11 2011-11-11 Compounds useful as akt/pkb modulators and uses thereof WO2012158197A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41244810P 2010-11-11 2010-11-11
US61/412,448 2010-11-11

Publications (2)

Publication Number Publication Date
WO2012158197A2 WO2012158197A2 (en) 2012-11-22
WO2012158197A3 true WO2012158197A3 (en) 2013-03-14

Family

ID=47177531

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/060467 WO2012158197A2 (en) 2010-11-11 2011-11-11 Compounds useful as akt/pkb modulators and uses thereof

Country Status (1)

Country Link
WO (1) WO2012158197A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044311B (en) * 2012-12-26 2015-04-22 山东大学 Multi-substituted indole compounds and preparation method and application thereof
CN103399100A (en) * 2013-08-13 2013-11-20 中国热带农业科学院农产品加工研究所 Measuring method of vitamin E content in fruits
WO2015097667A2 (en) * 2013-12-23 2015-07-02 Cellworks Group, Inc., A composition, process of preparation of said composition, kit and a method of treating cancer
CN115025097A (en) * 2022-06-30 2022-09-09 四川大学 Application of raltitrexed in preparation of medicine targeting CHMP3 gene

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US6331287B1 (en) * 1995-08-23 2001-12-18 University Advanced Bio-Imaging Associates 2′-deoxy-2′-fluoro-d-arabinofuranosyl pyrimidine nucleoside
WO2005113762A1 (en) * 2004-05-18 2005-12-01 Pfizer Products Inc. CRYSTAL STRUCTURE OF PROTEIN KINASE B-α (AKT-1) AND USES THEREOF
US7081449B2 (en) * 2000-07-06 2006-07-25 Valeant Research & Development Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
WO2009009793A2 (en) * 2007-07-12 2009-01-15 University Of South Florida Inhibitors of akt/pkb with anti-tumor activity
US7678801B2 (en) * 2005-03-25 2010-03-16 Glaxo Group Limited Compounds
US20100261667A1 (en) * 2001-11-27 2010-10-14 Anadys Pharmaceuticals, Inc. 3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US6331287B1 (en) * 1995-08-23 2001-12-18 University Advanced Bio-Imaging Associates 2′-deoxy-2′-fluoro-d-arabinofuranosyl pyrimidine nucleoside
US7081449B2 (en) * 2000-07-06 2006-07-25 Valeant Research & Development Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
US20100261667A1 (en) * 2001-11-27 2010-10-14 Anadys Pharmaceuticals, Inc. 3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
WO2005113762A1 (en) * 2004-05-18 2005-12-01 Pfizer Products Inc. CRYSTAL STRUCTURE OF PROTEIN KINASE B-α (AKT-1) AND USES THEREOF
US7678801B2 (en) * 2005-03-25 2010-03-16 Glaxo Group Limited Compounds
WO2009009793A2 (en) * 2007-07-12 2009-01-15 University Of South Florida Inhibitors of akt/pkb with anti-tumor activity

Also Published As

Publication number Publication date
WO2012158197A2 (en) 2012-11-22

Similar Documents

Publication Publication Date Title
WO2009152356A3 (en) Compounds and compositions useful for the treatment of malaria
WO2006102610A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
EP2086540B8 (en) Triazolopyridine compounds useful for the treatment of degenerative & inflammatory diseases
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
WO2014007951A3 (en) Substituted tricyclic compounds as fgfr inhibitors
WO2007109192A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2013036912A3 (en) Amido compounds as rorϒtmodulators and uses thereof
WO2007109172A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2013163190A8 (en) Dna-pk inhibitors
WO2009156462A3 (en) Organic compounds
WO2012027728A3 (en) Compositions and methods for targeted thermomodulation
WO2008070129A3 (en) Compositions and methods for the treatment of inflammatory disease
WO2007109154A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2010058032A3 (en) Substituted pyrimidines for the treatment of diseases such as cancer
WO2010111406A3 (en) Purine derivatives useful as anti - cancer agents
WO2007109160A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2012074547A3 (en) STEROID COMPOUNDS AS RORγt MODULATORS AND USES THEREOF
WO2009129246A3 (en) Compositions and methods for preparing and using same
WO2007109182A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007109279A3 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
WO2012103810A1 (en) Certain chemical entities, compositions, and methods
WO2008097924A3 (en) Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders
WO2011123678A3 (en) Substituted benzo-pyrido-triazolo-diazepine compounds
GB201213267D0 (en) Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
WO2011023367A3 (en) Bisphosphonate-prodrugs

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11865643

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11865643

Country of ref document: EP

Kind code of ref document: A2