WO2012149097A3 - Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof - Google Patents

Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof Download PDF

Info

Publication number
WO2012149097A3
WO2012149097A3 PCT/US2012/035105 US2012035105W WO2012149097A3 WO 2012149097 A3 WO2012149097 A3 WO 2012149097A3 US 2012035105 W US2012035105 W US 2012035105W WO 2012149097 A3 WO2012149097 A3 WO 2012149097A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
methods
guanidylimidazoline
guanidylimidazole
synthesis
Prior art date
Application number
PCT/US2012/035105
Other languages
French (fr)
Other versions
WO2012149097A2 (en
Inventor
Ai J. Lin
Michael P. Kozar
Micahel T. O'NEIL
Liang Zhang
Original Assignee
The United States Of America, As Represented By The Secretary Of Army,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America, As Represented By The Secretary Of Army, filed Critical The United States Of America, As Represented By The Secretary Of Army,
Publication of WO2012149097A2 publication Critical patent/WO2012149097A2/en
Publication of WO2012149097A3 publication Critical patent/WO2012149097A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to new guanidylimidazole derivatives and guanidylimidazoline derivatives, methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.
PCT/US2012/035105 2011-04-26 2012-04-26 Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof WO2012149097A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161517858P 2011-04-26 2011-04-26
US61/517,858 2011-04-26

Publications (2)

Publication Number Publication Date
WO2012149097A2 WO2012149097A2 (en) 2012-11-01
WO2012149097A3 true WO2012149097A3 (en) 2014-05-01

Family

ID=47073059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/035105 WO2012149097A2 (en) 2011-04-26 2012-04-26 Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2012149097A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148645A1 (en) * 2003-11-21 2005-07-07 Lin Ai J. 2-Guanidinylimidazolidinedione compounds and methods of making and using thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148645A1 (en) * 2003-11-21 2005-07-07 Lin Ai J. 2-Guanidinylimidazolidinedione compounds and methods of making and using thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAIN ET AL.: "Antimalarial Activities of Ring-Substituted Bioimidazoles.", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 12, 2002, pages 1701 - 1704 *
SUH ET AL.: "Novel Potent Antagonists of Transient Receptor Potential Channel, Vanilloid Subfamily Member 1: Structure-Activity Relationship of 1,3-Diarylalkyl Thioureas Possessing New Vanilloid Equivalents.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5823 - 5836 *

Also Published As

Publication number Publication date
WO2012149097A2 (en) 2012-11-01

Similar Documents

Publication Publication Date Title
HK1254470A1 (en) 3' equatorial-fluorine-substituted neuraminidase inhibitor compounds, compositions and methods for the use thereof as anti-virals
WO2011153157A3 (en) Benzoquinolone inhibitors of vmat2
IL235944A0 (en) Β-lactamase inhibitor compounds, compositions comprising same, methods of producing same and uses thereof
WO2012019426A8 (en) Phthalazinone derivative, and preparation method and pharmaceutical use thereof
PL2768937T3 (en) Formulations, their use as or for the manufacture of dishwashing agents and their manufacture
WO2012042371A3 (en) Pharmaceutical composition
WO2012019430A8 (en) Phthalazinone derivative, and preparation method and pharmaceutical use thereof
WO2012122383A3 (en) Pi3 kinase inhibitors and uses thereof
PH12014501273A1 (en) Intranasal dexmedetomidine compositions and methods of use thereof
CA2873723A1 (en) Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
WO2012065019A3 (en) Combination comprising pyridopyrimidinone inhibitors of pi3k alpha
WO2014086982A3 (en) Stable metal compounds, their compositions and methods of their use
CA2830549C (en) Methods and compositions for preparing noribogaine from voacangine
EP2702054A4 (en) Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
WO2012065057A3 (en) Phosphatidylinositol 3-kinase inhibitors and methods of their use
WO2013188417A3 (en) Treatment and prevention of cardiovascular disease and thrombosis
EP2590971A4 (en) Compounds useful as antiviral agents, compositions, and methods of use
WO2013057013A3 (en) Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
WO2013055687A3 (en) R(+)-n-formyl-propargyl-aminoindan
MX2016003823A (en) A selective inhibitor of phosphatidylinositol 3-kinase-gamma.
HK1198929A1 (en) 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same 34-
TN2013000283A1 (en) Monoterpene derivatives of chalcone or dihydrochalcone and their use as depigmenting agents
WO2012162513A3 (en) Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase i inhibitors
MX2014001604A (en) Anthranilamide compounds and their use as pesticides.
MX2014001510A (en) Anthranilamide compounds and their use as pesticides.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12776477

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 12776477

Country of ref document: EP

Kind code of ref document: A2