WO2012146458A3 - A method for producing a polymer-based microfluidics system for bioanalytics using biological membranes - Google Patents

A method for producing a polymer-based microfluidics system for bioanalytics using biological membranes Download PDF

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Publication number
WO2012146458A3
WO2012146458A3 PCT/EP2012/055591 EP2012055591W WO2012146458A3 WO 2012146458 A3 WO2012146458 A3 WO 2012146458A3 EP 2012055591 W EP2012055591 W EP 2012055591W WO 2012146458 A3 WO2012146458 A3 WO 2012146458A3
Authority
WO
WIPO (PCT)
Prior art keywords
foil
polymer
pores
producing
high performance
Prior art date
Application number
PCT/EP2012/055591
Other languages
French (fr)
Other versions
WO2012146458A2 (en
Inventor
Ingrid IMHOF
Eugen Müller
Helmut Schift
Louis Tiefenauer
Original Assignee
Paul Scherrer Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paul Scherrer Institut filed Critical Paul Scherrer Institut
Publication of WO2012146458A2 publication Critical patent/WO2012146458A2/en
Publication of WO2012146458A3 publication Critical patent/WO2012146458A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/019—Bonding or gluing multiple substrate layers

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Laminated Bodies (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Fully polymer-based microfluidic system containing a thin PEEK polymer sheet in which one pore or arrays of pores of 1 to 20 micrometer diameter and a low aspect ratio of about 1:1 allow spontaneous formation of lipid bilayers. Such device allows the simple preparation of bilayers and electrochemical and optical detection of signals related to membrane-associated protein activities and perfusion. The method for producing such a microfluidic system comprises the steps of: • a) providing a first high performance thermoplastic polymer foil (2); • b) generating a plurality of pores (6) in said first foil (2); • c) providing at least one second high performance thermoplastic polymer foil (4) having an embossed channel structure (8) for guiding a liquid; • d) aligning the first foil (2) and at least one second foil (4) in order to enable an access to the channel structure (8) via the pores (6); and • e) bonding the first foil (2) to at least one second foil (4) by thermal pressing with a pressure power of up to 2.5 MN and a predetermined course of the temperature in the range of 20 to 160°C.
PCT/EP2012/055591 2011-04-26 2012-03-29 A method for producing a polymer-based microfluidics system for bioanalytics using biological membranes WO2012146458A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11163710 2011-04-26
EP11163710.4 2011-04-26

Publications (2)

Publication Number Publication Date
WO2012146458A2 WO2012146458A2 (en) 2012-11-01
WO2012146458A3 true WO2012146458A3 (en) 2013-01-03

Family

ID=45952497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/055591 WO2012146458A2 (en) 2011-04-26 2012-03-29 A method for producing a polymer-based microfluidics system for bioanalytics using biological membranes

Country Status (1)

Country Link
WO (1) WO2012146458A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11027474B2 (en) 2015-07-27 2021-06-08 Beth Israel Deaconess Medical Center Inc. Fluidic systems, devices and methods for inducing anisotropy in polymeric materials

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1350759A2 (en) * 2002-04-02 2003-10-08 Agilent Technologies Inc. (a Delaware Corporation) Methods for embossing and bonding of PAEK for microfluidic devices
WO2007029132A2 (en) * 2005-09-09 2007-03-15 Koninklijke Philips Electronics N. V. A method of manufacturing a microsystem, such a microsystem, a stack of foils comprising such a microsystem, an electronic device comprising such a microsystem and use of the electronic device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1548444A1 (en) 2003-12-23 2005-06-29 Paul Scherrer Institut An assay chip, and uses of said assay chip to determine molecular structures and functions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1350759A2 (en) * 2002-04-02 2003-10-08 Agilent Technologies Inc. (a Delaware Corporation) Methods for embossing and bonding of PAEK for microfluidic devices
WO2007029132A2 (en) * 2005-09-09 2007-03-15 Koninklijke Philips Electronics N. V. A method of manufacturing a microsystem, such a microsystem, a stack of foils comprising such a microsystem, an electronic device comprising such a microsystem and use of the electronic device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HWANG W ET AL: "Polyether ether ketone microstructures for chemical analytics", MICROSYSTEM TECHNOLOGIES ; MICRO AND NANOSYSTEMS INFORMATION STORAGE AND PROCESSING SYSTEMS, SPRINGER, BERLIN, DE, vol. 14, no. 9-11, 18 January 2008 (2008-01-18), pages 1699 - 1700, XP019632826, ISSN: 1432-1858 *

Also Published As

Publication number Publication date
WO2012146458A2 (en) 2012-11-01

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