WO2012137751A1 - Unit for oral cavity care - Google Patents

Abstract

Provided is a unit for oral cavity care, said unit allowing a drug to fully exert the effect thereof. The unit for oral cavity care, which comprises an oral cavity preparation and an application device (1) for applying the oral cavity preparation in the oral cavity, wherein the oral cavity preparation contains a cationic bactericide as the active ingredient thereof, and the application device (1) is provided with a handle (4), a conductive applicator (2) formed on the handle (4), a power source, an anode terminal (5) that is connected to the anode of the power source and formed in an exposed state in the handle (4), and a cathode terminal (3) that is connected to the cathode of the power source and to the applicator (2) and separated from the anode terminal (5).

Description

Oral care unit

The present invention relates to an oral care unit.
This application claims priority based on Japanese Patent Application No. 2011-086318 filed in Japan on April 8, 2011, the contents of which are incorporated herein by reference.

In order to prevent periodontal disease, it is important to sterilize periodontal bacteria and remove biofilms, but it is difficult to remove biofilms formed in the interdental region and the cervical region with a normal toothbrush.
In order to prevent and improve periodontal disease, it is effective to apply an oral preparation containing an active ingredient such as sterilization to the interdental or cervical region to kill the causative pathogenic bacteria. Has been. Generally, cationic fungicides such as quaternary ammonium salts are used as the fungicides.

Conventionally, various interdental brushes have been proposed for the purpose of cleaning the interproximal portion and applying a drug to the interproximal portion.
An interdental cleaning tool has been proposed in which a chemical solution is accommodated in a cavity of a handle formed of a deformable elastic material, and a small hole is formed in the vicinity of a brush mounting base so as to communicate the cavity with an external space ( For example, Patent Document 1). According to the invention of Patent Document 1, it is intended to apply the chemical solution in the handle cavity to the interdental portion while cleaning the interdental portion with a brush.
Further, a small brush for interdental portions using a hollow fiber has been proposed (for example, Patent Document 2). According to the invention of Patent Document 2, it is attempted to efficiently remove plaque at the interdental portion by previously inserting a dentifrice component into the hollow fiber.
Alternatively, an interdental brush in which an inorganic powder is kneaded with a resin filament and an active ingredient is adsorbed on the inorganic powder exposed on the surface of the resin filament has been proposed (for example, Patent Document 3). According to the invention of Patent Document 3, an active ingredient adsorbed on a resin filament is applied to an affected part while cleaning the interdental part.

Also, as an instrument for efficiently removing plaque, an ion toothbrush (for example, Patent Document 4) and an ion interdental brush (for example, Patent Document 5) have been proposed. Saliva contains positively charged calcium ions, and these calcium ions crosslink negatively charged teeth with negatively charged dental plaque. The inventions of Patent Documents 4 and 5 introduce negative ions into the oral cavity, neutralize the charge of calcium ions in plaque, weaken plaque adsorption, and remove plaque by scrubbing. .

Japanese Utility Model Publication No. 63-194633 JP-A-5-192355 JP 2003-61746 A JP 2001-190336 A JP-A-10-243820

However, in the inventions of Patent Documents 1 to 3, it is difficult to release the drug from the interdental brush.
In the inventions of Patent Documents 4 to 5, although the removal of plaque is promoted, it has not yet been satisfactory in terms of prevention and improvement of periodontal disease.
In addition, there is a problem that even if a drug such as a cationic bactericide is simply applied to the affected area, the effect of the drug is not sufficiently exhibited.
Then, an object of this invention is to provide the intraoral care unit which can fully exhibit the effect of a chemical | medical agent.

In general, it is said that the cationic bactericidal agent has a high effect of killing pathogenic bacteria. However, even if the cationic bactericidal agent is applied to the oral cavity, it is difficult to obtain a sufficient effect.
As a result of intensive studies, the present inventor found that the biofilm in the oral cavity is anionic, so that even if a cationic bactericidal agent is simply applied to the affected area, the cationic bactericidal agent cannot act on bacteria in an effective state. I got the knowledge.
As a result of further investigation based on the above knowledge, the present inventor has introduced a positive charge into the oral cavity so that the cationic fungicide can efficiently penetrate into the biofilm and can be effectively acted on. The headline, the present invention has been reached.

That is, the oral care unit of the present invention is an oral care unit comprising an oral preparation and an applicator for applying the oral preparation to the oral cavity, wherein the oral preparation is cationic sterilization as an active ingredient. The applicator includes a gripping body, a conductive applicator provided on the gripping body, a power source, and a negative electrode terminal connected to the negative electrode of the power source and exposed to the gripping body And a positive electrode terminal connected to the positive electrode of the power source and the coated body and spaced apart from the negative electrode terminal.
The application body is preferably composed of a conductive polymer, and the active ingredient is preferably a quaternary ammonium salt.
The intraoral care unit in which the volume resistivity of the application body is 1 × 10 ² Ω · cm or less.
The active ingredient is quaternary ammonium salt such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyldimethylbenzylammonium chloride, lauryltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, The oral care unit described above, wherein the oral care unit is selected from biguanide fungicides such as chlorhexidine hydrochloride, chlorhexidine gluconate, alexidine hydrochloride, or alexidine gluconate.
The oral care unit, wherein the active ingredient is a quaternary ammonium salt.
The said oral care unit whose content of the cationic microbicide in an intraoral formulation is 0.001 mass% or more and 0.2 mass% or less with respect to 100 mass% of oral preparations.
The intraoral care unit in which the conductive substance contained in the conductive polymer is selected from metals such as gold and silver, metal oxides such as titanium oxide and zinc oxide, and carbon.
The shape of the application body is an intraoral care unit having a conical shape with a diameter decreasing toward the tip of the application body.
An intraoral care unit in which two or more grooves extending in the circumferential direction are formed on the side surface of the application body.
An intraoral care unit in which a concave strip extending in a spiral shape is formed on a side surface of the application body.
An intraoral care unit in which a concave line extending from the base end to the tip end of the application body is formed on the side surface of the application body.
An intraoral care unit in which the application body has a rectangular plate shape with the extending direction of the positive electrode terminal as a longitudinal direction.
An oral care unit in which the application body is formed by forming a brush portion made of two or more conductive filaments on a support portion, and the brush portion is reduced in diameter from the base end to the tip end of the application body.
The conductive filament forming the brush portion includes a filament obtained by spinning a conductive polymer, a filament having a core-sheath structure in which a conductive polymer is used as a core and is coated with a polymer that does not contain a conductive substance, and a conductive polymer is used as an island. An oral care unit selected from a sea-island filament with a polymer that does not contain a conductive material as a sea, and a filament that has a surface coated with a conductive material by spinning a polymer that does not contain a conductive material.
The thickness of the said conductive filament is (phi) 0.05-0.3 mm, The intraoral care unit characterized by the above-mentioned.
In the oral cavity care unit, the application body is formed by forming a brush portion made of two or more conductive filaments on a support portion, and the brush portion has the same diameter from the base end to the tip end of the application body.

According to the intraoral care unit of the present invention, the effect of the drug can be sufficiently exerted.

It is a top view of the applicator concerning one Embodiment of this invention. It is sectional drawing of the applicator concerning one Embodiment of this invention. It is a top view of the application object concerning one embodiment of the present invention. It is a top view of the application object concerning one embodiment of the present invention. It is a top view of the application object concerning one embodiment of the present invention. It is a top view of the application object concerning one embodiment of the present invention. It is a top view of the application object concerning one embodiment of the present invention. It is a top view of the application object concerning one embodiment of the present invention. It is a schematic diagram which shows the experimental system of a model sterilization test.

The oral care unit of the present invention comprises an oral preparation containing a cationic bactericide and an applicator for applying the oral preparation to the oral cavity.
Note that “oral care” is an act of maintaining oral hygiene such as cleaning of the oral cavity, massage of the gums, treatment, improvement or prevention of periodontal disease or cavity.

(Oral preparation)
The oral preparation of the present invention contains a cationic fungicide.
The dosage form of the oral preparation is not particularly limited, and for example, a liquid form such as an aqueous solution or an aqueous dispersion, a sol form, a gel form, a powder form, and the like can be adopted as in the conventional oral preparation.

<Cationic fungicide>
The cationic fungicide is not particularly limited as long as it is a component conventionally used in oral preparations. For example, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyldimethylbenzylammonium chloride, lauryltrimethylammonium chloride. And quaternary ammonium salts such as myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, and biguanide fungicides such as chlorhexidine hydrochloride, chlorhexidine gluconate, alexidine hydrochloride, and alexidine gluconate. Of the cationic bactericides, quaternary ammonium salts having excellent bactericidal activity are preferred, cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride are more preferred, and cetylpyridinium chloride is more preferred. These cationic fungicides can be used alone or in combination of two or more.

The content of the cationic fungicide in the oral preparation can be determined in consideration of the kind of the cationic fungicide, and is preferably 0.001% by mass or more and 0.2% by mass or less, and 0.01% by mass or more and 0.0. 1 mass% or less is more preferable.

<Optional component>
In the oral preparation of the present invention, surfactants other than cationic fungicides (arbitrary drugs), abrasives, thickeners, caking agents, and cationic fungicides are excluded as long as the effects of the present invention are not impaired. You may mix | blend an agent (optional surfactant), a sweetener, a pigment | dye, a fragrance | flavor, a pH adjuster, a buffering agent, etc.

[Optional drug]
Optional drugs include anti-inflammatory agents such as tranexamic acid, epsilon caproic acid, β-glycyrrhizic acid, dipotassium glycyrrhizinate, antioxidants such as ascorbic acid and ascorbic acid derivatives such as ascorbyl magnesium phosphate, sodium fluoride, fluoride Fluorides such as potassium, stannous fluoride, strontium fluoride, sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, allantochlorohydroxyaluminum, hinokitiol, sodium chloride, acetic acid dl-tocopherol, dihydrocholesterol, α-bisabolol, triclosan, isopropylmethylphenol, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, etc. Rate phosphate compound, copper compound such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or derivatives thereof, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, Examples include plant extracts such as trichlorocarbanilide, zinc citrate, sugar beet extract, buckwheat extract, chamomile, clove, rosemary, hornon, safflower and the like. These optional drugs can be used singly or in appropriate combination of two or more.
In addition, the addition amount of the arbitrary chemical | medical agent in an intraoral composition can be made into an effective amount in the range which does not prevent the effect of this invention.

Examples of the abrasive include dicalcium phosphate dihydrate, anhydrous dibasic calcium phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy Calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, synthetic resin-based abrasive , Precipitated silica, silica gel, aluminosilicate, zirconosilicate and the like. The content of the abrasive in the oral preparation is, for example, 5% by mass or more and 50% by mass or less.

As the thickening agent, glycerin, sorbite, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, sugar alcohol such as reduced starch saccharified product, and at least one kind of polyhydric alcohol can be used. The content of the viscous agent in the oral preparation is, for example, 10% by mass or more and 40% by mass or less.

Examples of binders include organic binders such as sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, xanthan gum, carbopol, guar gum, gelatin, and avicel, montmorillonite, and kaolin. And inorganic binders such as bentonite. The content of the binder in the oral preparation is, for example, 0.5% by mass or more and 3% by mass or less.

As the optional surfactant, known anionic surfactants, nonionic surfactants, and amphoteric surfactants can be added. Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine, sodium myristyl sarcosine, polyoxyethylene alkyl sulfate, N-lauroyl taurate, α-olefin sulfonic acid Examples include salts. Nonionic surfactants include, for example, alkyl glycosides having 8 to 16 carbon atoms in the alkyl group, sucrose fatty acid esters having 12 to 18 carbon atoms in the fatty acid group such as sucrose mono- or dilaurate, lactose fatty acid esters, Polyalkyl alcohol fatty acid esters such as lactitol fatty acid ester, maltitol fatty acid ester and stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, and alkyl such as lauroyl diethanolamide Roylethanolamide, polyoxyethylene polyoxypropylene glycol, decaglyceryl laurate and the like can be mentioned. Examples of the amphoteric surfactant include alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like.

These optional surfactants can be used singly or in appropriate combination of two or more. The content of the optional surfactant in the oral preparation is, for example, 0.1% by mass or more and 3% by mass or less.

Examples of sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin.

(Applicator)
An applicator according to an embodiment of the present invention will be described below with reference to the drawings.
The applicator 1 shown in FIGS. 1 and 2 is a so-called ion interdental brush provided with an applicator 2, a gripper 4, a positive electrode terminal 3, and a negative electrode terminal 5.

As shown in FIG. 2, a battery 6 is provided in the holding body 4, and a negative electrode conductive unit 50 connected to the negative electrode 62 of the battery 6 and a positive electrode conductive unit 30 connected to the positive electrode 64 of the battery 6. Is provided.
The negative electrode conductive portion 50 is connected to the negative electrode terminal 5 provided to be exposed on the grip body 4.
The positive electrode conductive portion 30 is connected to the positive electrode terminal 3 that is a conducting wire protruding from the tip of the grip body 4, and the coating body 2 is provided on the positive electrode terminal 3 so as to cover the tip 32 of the positive electrode terminal 3.

The grip body 4 is a bottomed cylinder. The length L from the rear end to the front end of the grip body 4 is not particularly limited, and is, for example, 5 cm or more and 20 cm or less. The rear end of the grip body 4 is an end on the negative electrode conductive unit 50 side, and the front end is an end on the positive electrode conductive unit 30 side. The maximum thickness R of the grip body 4 is not particularly limited and is, for example, 1.6 cm or more and 5 cm or less. The material of the holding body 4 is not particularly limited as long as it is an insulating material, and examples thereof include polyolefins such as polypropylene and polyethylene, polyesters such as polyethylene terephthalate, and resins such as polystyrene.

The application body 2 is a member that abuts on the surface of the gums or is inserted between the teeth and applies the oral preparation to oral tissues such as teeth and gums.
Although the material of the application body 2 will not be specifically limited if it has electroconductivity, Volume resistivity 1 * 10 < ² > ohm * cm or less is preferable and 60 ohm * cm or less is more preferable. When the upper limit value of 1 × 10 ² Ω · cm is exceeded, there is a possibility that unevenness occurs in the amount of current flowing through the portion of the coated body 2.
Although the hardness of the application body 2 is not specifically limited, in order to relieve physical irritation | stimulation to a tooth | gear and a gum, a flexible thing is preferable and hardness (measured value in durometer A) 15-80 is more preferable. .

Examples of such a material include polyolefins such as conductive silicon, polyethylene, polypropylene, or a mixture thereof in which a conductive material is contained in silicon rubber such as methyl silicon rubber, vinyl methyl silicon rubber, phenylmethyl silicon rubber, or a mixture thereof. Examples thereof include conductive polyolefins containing a conductive substance, conductive polyamides containing a conductive substance in a polyamide, and conductive polymers such as a conductive polyester containing a conductive substance in a polyester such as polyethylene terephthalate. .

Examples of the conductive substance contained in the conductive polymer include metals such as gold and silver, metal oxides such as titanium oxide and zinc oxide, and carbon, and the applied body 2 is used in the oral cavity. From the viewpoint of stability, carbon is preferable. These electroconductive substances can be used individually by 1 type or in combination of 2 or more types as appropriate.

The conductive polymer tends to become harder, although the volume resistivity decreases as the content of the conductive material increases. For this reason, the content of the conductive substance in the conductive polymer can be determined in consideration of the type of polymer and the type of conductive substance.

The shape of the application body 2 can be determined in consideration of the application target, and is, for example, a substantially conical shape whose diameter decreases toward the tip of the application body 2. By making the application body 2 into a substantially conical shape, the oral preparation can be easily applied to narrow portions such as an interdental portion and a boundary between a tooth and a gum.

Further, as another form, there may be mentioned an application body 100 shown in FIG. 3A having a substantially conical shape and two or more concave stripes 102 extending in the circumferential direction formed on the side surface. The application body 100 can apply the oral preparation to the application target while holding the oral preparation with the recess 102. The material of the application body 100 is the same as the material of the application body 2.

Further, for example, there may be mentioned an application body 110 shown in FIG. 3B, which has a substantially conical shape and is formed with a concave stripe 112 extending spirally on the side surface. The application body 110 can apply the oral preparation to the application target while holding the oral preparation with the recess 112. The material of the application body 110 is the same as the material of the application body 2.

Alternatively, as shown in FIG. 3C, an application body 120 having a substantially conical shape and having a concave line 122 extending from the base end of the application body 120 toward the distal end of the application body 120 is formed on the side surface. The application body 120 can apply the oral preparation to the application target while holding the oral preparation with the recess 122. The material of the application body 120 is the same as the material of the application body 2.

As yet another form, a plate shape having a substantially rectangular shape in a plan view with the extending direction of the positive electrode terminal 3 as the longitudinal direction may be used like an application body 130 shown in FIG. 3D. Since the application body 130 is plate-shaped, it is suitable for applying the oral preparation to a wide area. The material of the application body 130 is the same as the material of the application body 2.

Further, for example, as in the application body 140 shown in FIG. 3E, a brush part 144 made of two or more conductive filaments (conductive filaments) is formed on the support part 142. The brush portion 144 has a shape that decreases in diameter from the proximal end toward the distal end. The material of the support part 142 is the same as the material of the application body 2.

The conductive filament forming the brush portion 144 is a filament obtained by spinning a conductive polymer, a filament having a core-sheath structure in which the conductive polymer is a core and is coated with a polymer not containing a conductive substance, and the conductive polymer is an island. And a filament having a sea-island structure in which a polymer not containing a conductive substance is used as a sea, and a filament having a surface coated with a conductive substance spun on a polymer not containing a conductive substance. Such a filament is used individually by 1 type or in combination of 2 or more types as appropriate.
The conductive filament preferably has a volume resistivity of 1 × 10 ² Ω · cm or less, and more preferably 60 Ω · cm or less.
The thickness of the conductive filament is not particularly limited, and is, for example, φ0.05 mm or more and 0.3 mm or less.

In addition, for example, a brush part 154 made of a conductive filament is formed on the support part 152 as in the application body 150 shown in FIG. 3F. The brush portion 154 has a diameter approximately the same from the base end to the tip.
The conductive filament that forms the brush portion 154 is the same as the conductive filament that forms the brush portion 144.

Further, as another form, an applied body may be obtained by twisting together conductive or non-conductive filaments with a conductive wire. However, from the viewpoint of alleviating irritation to the interdental portion, it is preferable that the application body is provided so as to cover the positive electrode terminal such as a wire.

The material of the positive electrode terminal 3 may be any material as long as it has conductivity, and examples thereof include metals such as gold and silver, metal oxides such as titanium oxide and zinc oxide, and carbon.
The material of the positive electrode conductive portion 30 is the same as that of the positive electrode terminal 3.

The material of the negative electrode terminal 5 is the same as that of the positive electrode terminal 3, and the material of the negative electrode conductive portion 50 is the same as that of the positive electrode terminal 3.

(Method of oral care)
Next, a method of oral care using the applicator 1 will be described by taking periodontal disease biofilm sterilization as an example.
First, the oral preparation is attached to the application body 2, and the hand is brought into contact with the negative electrode terminal 5 to grip the grip body 4. The application body 2 is inserted into the oral cavity, for example, between the teeth. When the application body 2 is inserted into the interdental area, the application body 2 gets wet by the oral preparation, saliva, or moisture in the oral cavity, and the oral tissue and the application body 2 are electrically connected. The current flows in the order of the negative electrode 62 of the battery 6, the negative electrode conductive part 50, the negative electrode terminal 5, the user's hand, body, oral cavity, application body 2, positive electrode terminal 3, positive electrode conductive part 30, positive electrode 64. At this time, positive charge convection is generated from the coated body 2 toward the oral tissue, and the positive charge cationic bactericidal agent repelled by the convection permeates the biofilm. As a result, the cationic fungicide acts on pathogenic bacteria in the biofilm and kills these pathogenic bacteria. In addition, since a current of 1 to 100 μA flows through the human body, the current promotes the circulation of the gums and activates the gum tissue.

As described above, according to the present embodiment, since an oral preparation containing a cationic disinfectant and an applicator provided with an application body on the positive electrode terminal are provided, the cationic disinfectant is efficiently contained in the biofilm. The effect of the cationic bactericide can be sufficiently exhibited.
In addition, since the application body is made of a soft conductive polymer, physical irritation to teeth and gums can be alleviated.

(Other embodiments)
The present invention is not limited to the embodiment described above.
In the above-described embodiment, the applicator is an ion interdental brush. However, the applicator only needs to be provided with an applicator on the positive electrode terminal, and includes, for example, a head portion extending on the gripper. A so-called ion toothbrush may be provided in which a negative electrode terminal is provided on the gripping body, and a positive electrode terminal and a conductive filament covering the positive electrode terminal are implanted in the head portion. The filament used in the ion toothbrush is preferably a so-called tapered hair having a shape that gradually decreases in diameter toward the tip. Since the tapered hair is easy to bend, it is difficult to give pain to the affected part, and it can penetrate into a fine gap to allow the cationic disinfectant to penetrate into the biofilm.

In the above-described embodiment, the applicator of FIGS. 3A to 3C has a groove on the side surface. However, the present invention is not limited to this, and on the side surface of the applicator, a protrusion is used instead of the groove. May be formed.

In the above-described embodiment, the ionic interdental brush in which the application body extends in the length direction of the gripping body has been described as an example. However, the present invention is not limited to this, and for example, the applicator is the length of the gripping body. It may be an ion interdental brush in which the application body is connected in a direction crossing the vertical direction.

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following description.

(Manufacture example 1) Preparation of an oral preparation A cetyl pyridinium chloride (CPC) is melt | dissolved in pH 7.0 phosphate buffered saline (PBS solution), 0.1 mass% CPC solution is prepared, and an oral preparation and did.

Example 1
Conductive silicon (conductive material: carbon, volume resistivity 20 Ω · cm) formed into a conical shape with a diameter of 3 mm at the base end and a length of 10 mm (hardness (measured with durometer A) = 50) The same applicator as the applicator 1 of FIG. The applicator used was a polypropylene molded body as a gripping body, a 0.25 mm diameter SUS304 wire as a positive electrode terminal, and a titanium oxide flat plate as a negative electrode terminal. A 9V battery was used as a power source.
Using the obtained applicator, the bactericidal effect and feeling of use were evaluated by the methods shown below, and the results are shown in Table 1.

(Evaluation methods)
<Bactericidal effect>
The sterilization effect was evaluated by a model sterilization test using the experimental system 200 shown in FIG.
The experimental system 200 includes an outer container 230, an inner container 220 provided in the outer container 230, the applicator 1, and a conductive negative electrode extension 52.

The outer container 230 and the inner container 220 were set as shown in FIG. In the outer container 230, the PBS solution 232 was stored, and in the inner container 220, the model biofilm 224 was formed on the membrane filter 221 provided on the inner bottom surface, and the oral preparation 222 was stored. The model biofilm 224 is prepared in accordance with the method of Morishima et al. (Oral Hygiene Journal 54 (4) 437, 2004), Actinomyces viscosus, Bayonella parvula, V. parvula, F. nucleatum. ), P. gingivalis (P. gingivalis) four-type mixed culture. The applicator 2 of the applicator 1 was immersed in the oral preparation 222 and the negative electrode extension 52 was connected to the negative electrode terminal 5. The tip of the negative extension 52 was connected to the negative electrode plate 54 located in the PBS solution 232. After energizing for 10 minutes with a direct current of 9 V, the viable cell count of the model biofilm 224 was measured.

<Viable count>
At the end of the experiment, the biofilm on the membrane filter was sampled, dispersed with ultrasound, cultured on an agar plate, and P. The number of gingivalis colonies was counted to determine the number of viable bacteria (CFU / disk), and expressed in the common logarithm log CFU (abbreviation of CFU: colony forming unit).

<Usage>
Ten monitors evaluated the presence or absence of irritation to the gums when the application body was inserted into the interdental region and when the application body was pulled out from the interdental region, according to the following evaluation criteria. The average of 10 evaluation points was evaluated as “A” when the score was 2.5 or more, “B” when 2 or more and less than 2.5, and “C” when less than 2 points.

[Evaluation criteria]
3 points: There is almost no irritation to the gums.
2 points: Slight irritation to gums.
1 point: I strongly feel irritation to the gums.

(Example 2)
An applicator was obtained in the same manner as in Example 1 except that the hardness of the applicator was set to 80, and the feeling of use of the obtained applicator was evaluated. The evaluation results are shown in Table 1. In this example, only the difference in feeling of use due to the hardness of the coated body was confirmed, and thus the bactericidal effect was not evaluated.

(Example 3)
An applicator was obtained in the same manner as in Example 1 except that the hardness of the applicator was set to 90, and the feeling of use of the obtained applicator was evaluated. The evaluation results are shown in Table 1. In this example, only the difference in feeling of use due to the hardness of the coated body was confirmed, and thus the bactericidal effect was not evaluated.

(Comparative Example 1)
In place of the intraoral preparation 222 in the inner container 220, a PBS solution was used, and the applied body 2 was immersed in the PBS solution for 10 minutes without being energized. Then, the viable count of the biofilm was measured, and the results are shown in Table 1. Show. In addition, the feeling of use was evaluated, and the results are shown in Table 1.

(Comparative Example 2)
The number of viable bacteria in the biofilm was measured in the same manner as in Comparative Example 1 except that the oral preparation was used instead of the PBS solution, and the results are shown in Table 1. In addition, the feeling of use was evaluated, and the results are shown in Table 1.

(Comparative Example 3)
The energization process was performed for 10 minutes in the same manner as in Example 1 except that the PBS solution was used instead of the oral preparation 222 in the inner container 220. After energization treatment, the viable count of the biofilm was measured, and the results are shown in Table 1. In addition, the feeling of use was evaluated, and the results are shown in Table 1.

(Comparative Example 4)
In place of the oral preparation 222 in the inner container 220, an energization treatment was carried out for 10 minutes in the same manner as in Example 1 except that a 0.1% by mass isopropylmethylphenol (IPMP) aqueous solution was used.
After energization treatment, the viable count of the biofilm was measured, and the results are shown in Table 1. In addition, the feeling of use was evaluated, and the results are shown in Table 1.

(Comparative Example 5)
An insulating wire (φ0.25 mm, made of SUS) whose surface is covered with polyethylene is twisted and 300 nylon filaments (φ0.05 mm) are sandwiched between the wires, and the base end has a diameter of 3 mm and the tip. The coated body had a diameter of 2 mm and a length of 10 mm. About this application body, the bactericidal effect and a usability | use_condition are evaluated like Example 1, and the result is shown in Table 1.

As shown in Table 1, in Example 1 to which the present invention was applied, log CFU was 3.2 and the feeling of use was “A”. On the other hand, Comparative Examples 1, 2 and 5 in which positive charge convection does not occur from the coated body and Comparative Examples 3 and 4 using a PBS solution or an IPMP aqueous solution in place of the cationic disinfectant have a log CFU of 7 or more and are effective. No bactericidal effect was observed.
From these results, by using an oral care unit comprising an oral preparation containing a cationic bactericidal agent and an applicator having a positive electrode terminal connected to an applied body, the cationic bactericidal agent is effectively contained in a biofilm. It was found that it could penetrate.

The oral care unit of the present invention comprises an oral preparation containing a cationic bactericidal agent and an applicator for applying the oral preparation to the oral cavity, so that the oral care can sufficiently exert the effect of the drug. Units can be provided.

DESCRIPTION OF SYMBOLS 1 Applicator 2,100,110,120,13,140,150 Application body 3 Positive electrode terminal 4 Holding body 5 Negative electrode terminal 6 Battery

Claims (15)

1. In an oral care unit comprising an oral preparation and an applicator for applying the oral preparation to the oral cavity,
   The oral preparation contains a cationic fungicide as its active ingredient,
   The applicator includes a gripping body, a conductive applicator provided on the gripping body, a power source, a negative electrode terminal connected to a negative electrode of the power source and exposed to the gripping body, and the power source An intraoral care unit comprising a positive electrode and a positive electrode terminal connected to the application body and spaced apart from the negative electrode terminal.
2. The oral care unit according to claim 1, wherein the application body is made of a conductive polymer.
3. The intraoral care unit according to claim 2, wherein the volume resistivity of the application body is 1 × 10 ² Ω · cm or less.
4. The active ingredient is quaternary ammonium salt such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyldimethylbenzylammonium chloride, lauryltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, The intraoral care unit according to claim 1, characterized in that it is selected from biguanide fungicides such as chlorhexidine hydrochloride, chlorhexidine gluconate, alexidine hydrochloride and alexidine gluconate.
5. The oral care unit according to claim 4, wherein the active ingredient is a quaternary ammonium salt.
6. The oral care unit according to claim 1, wherein the content of the cationic bactericide in the oral preparation is 0.001% by mass or more and 0.2% by mass or less.
7. The oral care unit according to claim 2, wherein the conductive substance contained in the conductive polymer is selected from gold, silver metal, titanium oxide, zinc oxide metal oxide and carbon.
8. The intraoral care unit according to claim 1, wherein the shape of the application body is a conical shape whose diameter decreases toward the tip of the application body.
9. The intraoral care unit according to claim 8, wherein two or more ridges extending in the circumferential direction are formed on a side surface of the application body.
10. The intraoral care unit according to claim 8, wherein a spirally extending groove is formed on a side surface of the application body.
11. The intraoral care unit according to claim 8, wherein a concave strip extending from a base end of the applicator body toward a front end is formed on a side surface of the applicator body.
12. The intraoral care unit according to claim 1, wherein the application body has a rectangular plate shape whose longitudinal direction is the extending direction of the positive electrode terminal.
13. The said application body forms the brush part which consists of 2 or more filaments which have electroconductivity in a support part, The said brush part is diameter-reduced as it goes to a front-end | tip from the base end of an application body. The oral care unit as described.
14. The conductive filament forming the brush portion includes a filament obtained by spinning a conductive polymer, a filament having a core-sheath structure in which a conductive polymer is used as a core and is coated with a polymer that does not contain a conductive substance, and a conductive polymer is used as an island. 14. The filament according to claim 13, wherein the filament is selected from a filament having a sea-island structure in which a polymer not containing a conductive material is sea, and a filament having a surface coated with a conductive material spun on a polymer not containing a conductive material. Oral care unit.
15. The said application body forms the brush part which consists of 2 or more filaments which have electroconductivity in a support part, The said brush part is the same diameter toward the front-end | tip from an application body to the front-end | tip. The oral care unit as described.

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