WO2012129142A3 - Stereoselective process for preparing asymmetric malathion and analogs for pharmaceutical and agricultural use - Google Patents

Stereoselective process for preparing asymmetric malathion and analogs for pharmaceutical and agricultural use Download PDF

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Publication number
WO2012129142A3
WO2012129142A3 PCT/US2012/029594 US2012029594W WO2012129142A3 WO 2012129142 A3 WO2012129142 A3 WO 2012129142A3 US 2012029594 W US2012029594 W US 2012029594W WO 2012129142 A3 WO2012129142 A3 WO 2012129142A3
Authority
WO
WIPO (PCT)
Prior art keywords
malathion
analogs
pharmaceutical
agricultural use
stereoselective process
Prior art date
Application number
PCT/US2012/029594
Other languages
French (fr)
Other versions
WO2012129142A2 (en
Inventor
Charles M. Thompson
Original Assignee
Ateris Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ateris Technologies, Llc filed Critical Ateris Technologies, Llc
Publication of WO2012129142A2 publication Critical patent/WO2012129142A2/en
Publication of WO2012129142A3 publication Critical patent/WO2012129142A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The preparation of enantiomeric excess of a first enantiomer of malathion or an analog thereof from a solution of racemic malathion or an analog thereof, by stereoselectively hydrolyzing the first enantiomer to produce one or more monoacid enantiomers of the first enantiomer using an effective amount of a hydrolyzing agent and then subjecting the monoacid enantiomers to esterfication.
PCT/US2012/029594 2011-03-18 2012-03-18 Stereoselective process for preparing asymmetric malathion and analogs for pharmaceutical and agricultural use WO2012129142A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161454470P 2011-03-18 2011-03-18
US61/454,470 2011-03-18

Publications (2)

Publication Number Publication Date
WO2012129142A2 WO2012129142A2 (en) 2012-09-27
WO2012129142A3 true WO2012129142A3 (en) 2012-12-27

Family

ID=46879986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/029594 WO2012129142A2 (en) 2011-03-18 2012-03-18 Stereoselective process for preparing asymmetric malathion and analogs for pharmaceutical and agricultural use

Country Status (1)

Country Link
WO (1) WO2012129142A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080132470A1 (en) * 1999-03-12 2008-06-05 Michael Frank Treacy Synergistic insecticidal compositions
US20100179196A1 (en) * 2000-10-06 2010-07-15 Pershing Jay C Compositions and methods for deploying a transgenic refuge as a seed blend
US20100248334A1 (en) * 2002-09-09 2010-09-30 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080132470A1 (en) * 1999-03-12 2008-06-05 Michael Frank Treacy Synergistic insecticidal compositions
US20100179196A1 (en) * 2000-10-06 2010-07-15 Pershing Jay C Compositions and methods for deploying a transgenic refuge as a seed blend
US20100248334A1 (en) * 2002-09-09 2010-09-30 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IWONA POLEC ET AL.: "Simple syntheses of malathion and malaoxon enantiomers, and isomalathion diastereoisomers: toxicity-configuration relationship", PESTIC. SCI., vol. 53, 1998, pages 165 - 171 *

Also Published As

Publication number Publication date
WO2012129142A2 (en) 2012-09-27

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