WO2012122239A1 - MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER - Google Patents
MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER Download PDFInfo
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- WO2012122239A1 WO2012122239A1 PCT/US2012/028016 US2012028016W WO2012122239A1 WO 2012122239 A1 WO2012122239 A1 WO 2012122239A1 US 2012028016 W US2012028016 W US 2012028016W WO 2012122239 A1 WO2012122239 A1 WO 2012122239A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/65—MicroRNA
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12755097.8A EP2683387A4 (en) | 2011-03-07 | 2012-03-07 | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
AU2012225506A AU2012225506B2 (en) | 2011-03-07 | 2012-03-07 | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
JP2013557819A JP2014509852A (en) | 2011-03-07 | 2012-03-07 | Mutagenic activity induced by microRNA-155 (miR-155) links inflammation and cancer |
CN201280018289.9A CN103561750A (en) | 2011-03-07 | 2012-03-07 | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
CA2828772A CA2828772A1 (en) | 2011-03-07 | 2012-03-07 | Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161449854P | 2011-03-07 | 2011-03-07 | |
US61/449,854 | 2011-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012122239A1 true WO2012122239A1 (en) | 2012-09-13 |
Family
ID=46798544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/028016 WO2012122239A1 (en) | 2011-03-07 | 2012-03-07 | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
Country Status (7)
Country | Link |
---|---|
US (3) | US8664192B2 (en) |
EP (1) | EP2683387A4 (en) |
JP (1) | JP2014509852A (en) |
CN (1) | CN103561750A (en) |
AU (1) | AU2012225506B2 (en) |
CA (1) | CA2828772A1 (en) |
WO (1) | WO2012122239A1 (en) |
Cited By (11)
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CN103966328A (en) * | 2014-05-07 | 2014-08-06 | 新乡医学院 | miRNA marker related to malignant transformation of colitis and proctitis and kit |
US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
US8865885B2 (en) | 2006-03-20 | 2014-10-21 | The Ohio State University Research Foundation | MicroRNA fingerprints during human megakaryocytopoiesis |
US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
US8946187B2 (en) | 2010-11-12 | 2015-02-03 | The Ohio State University | Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer |
US9017939B2 (en) | 2006-01-05 | 2015-04-28 | The Ohio State University | Methods for diagnosing breast, colon, lung, pancreatic and prostate cancer using miR-21 and miR-17-5p |
US9085804B2 (en) | 2007-08-03 | 2015-07-21 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
US9249468B2 (en) | 2011-10-14 | 2016-02-02 | The Ohio State University | Methods and materials related to ovarian cancer |
US9481885B2 (en) | 2011-12-13 | 2016-11-01 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
US9499521B2 (en) | 2014-12-11 | 2016-11-22 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
US10758619B2 (en) | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
Families Citing this family (2)
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---|---|---|---|---|
US20150275209A1 (en) * | 2012-10-22 | 2015-10-01 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Service | Compositions and methods for enhancing cancer immunotherapy |
KR20190118688A (en) | 2015-06-05 | 2019-10-18 | 미라젠 세러퓨틱스 인코포레이티드 | miR-155 Inhibitors for Treating Cutaneous T Cell Lymphoma (CTCL) |
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Also Published As
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US20130065938A1 (en) | 2013-03-14 |
JP2014509852A (en) | 2014-04-24 |
AU2012225506B2 (en) | 2016-11-17 |
EP2683387A1 (en) | 2014-01-15 |
US20160289683A1 (en) | 2016-10-06 |
AU2012225506A1 (en) | 2013-09-19 |
EP2683387A4 (en) | 2014-09-03 |
CN103561750A (en) | 2014-02-05 |
CA2828772A1 (en) | 2012-09-13 |
US20140187609A1 (en) | 2014-07-03 |
US8664192B2 (en) | 2014-03-04 |
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