WO2012112792A3 - Multicomponent compositions and their uses - Google Patents
Multicomponent compositions and their uses Download PDFInfo
- Publication number
- WO2012112792A3 WO2012112792A3 PCT/US2012/025479 US2012025479W WO2012112792A3 WO 2012112792 A3 WO2012112792 A3 WO 2012112792A3 US 2012025479 W US2012025479 W US 2012025479W WO 2012112792 A3 WO2012112792 A3 WO 2012112792A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- multicomponent
- methods
- multicomponent composition
- component
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Multicomponent compositions and methods of use thereof are disclosed herein. Some embodiments of the present invention include multicomponent compositions comprising a first component and a second component, where the first component comprises a notch influencing molecule and the second component comprises a GPCR targeted molecule. Kits comprising the multicomponent composition are also disclosed. Methods for providing the multicomponent composition to one or more cells are additionally provided. Further embodiments include methods of using the multicomponent composition such as, for example, methods of administering the multicomponent composition and method of treating organisms (such as mammals) using the multicomponent composition.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2862798A CA2862798C (en) | 2011-02-17 | 2012-02-16 | Multicomponent compositions and their uses |
CN201280009550.9A CN103501823B (en) | 2011-02-17 | 2012-02-16 | Multi-component combination and their purposes |
US13/985,051 US9358272B2 (en) | 2011-02-17 | 2012-02-16 | Multicomponent compositions and their uses |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161463482P | 2011-02-17 | 2011-02-17 | |
US61/463,482 | 2011-02-17 | ||
US201161558227P | 2011-11-10 | 2011-11-10 | |
US61/558,227 | 2011-11-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012112792A2 WO2012112792A2 (en) | 2012-08-23 |
WO2012112792A3 true WO2012112792A3 (en) | 2013-02-21 |
Family
ID=46673182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/025479 WO2012112792A2 (en) | 2011-02-17 | 2012-02-16 | Multicomponent compositions and their uses |
Country Status (4)
Country | Link |
---|---|
US (1) | US9358272B2 (en) |
CN (2) | CN108514638A (en) |
CA (1) | CA2862798C (en) |
WO (1) | WO2012112792A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011162558A2 (en) * | 2010-06-24 | 2011-12-29 | (주)지노믹트리 | Recombinant vector for suppressing proliferation of human papillomavirus cell including adenylate cyclase activating polypeptide 1 (pituitary) gene and pharmaceutical composition for treating human papillomavirus |
CN108514638A (en) | 2011-02-17 | 2018-09-11 | 杜兰教育基金委员会 | Multi-component combination and their purposes |
TW201726746A (en) | 2012-11-07 | 2017-08-01 | 輝瑞股份有限公司 | Anti-Notch3 antibodies and antibody-drug conjugates |
EP3433259B1 (en) | 2016-03-24 | 2021-06-30 | The Administrators of The Tulane Educational Fund | Conjugates of tacrolimus, their compositions, and their uses |
US20210386877A1 (en) * | 2019-01-10 | 2021-12-16 | Andarix Pharmaceuticals, Inc. | Radiotherapeutic combination therapy for the treatment of cancer |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002010215A1 (en) * | 2000-07-31 | 2002-02-07 | Dabur Research Foundation | Somatostatin analogs for the treatment of cancer |
WO2003042246A2 (en) * | 2001-11-14 | 2003-05-22 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2461099A1 (en) * | 2001-09-21 | 2003-04-10 | The Administrators Of The Tulane Educational Fund | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
KR101003622B1 (en) | 2002-03-01 | 2010-12-24 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
CN101856348A (en) | 2003-08-29 | 2010-10-13 | 斯隆-凯特林癌症研究所 | The therapeutic alliance method for cancer |
EP1954284A4 (en) | 2005-11-04 | 2010-01-06 | Merck & Co Inc | Method of treating cancers with saha and pemetrexed |
CA2655362A1 (en) | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
CN108514638A (en) | 2011-02-17 | 2018-09-11 | 杜兰教育基金委员会 | Multi-component combination and their purposes |
-
2012
- 2012-02-16 CN CN201810311695.3A patent/CN108514638A/en active Pending
- 2012-02-16 US US13/985,051 patent/US9358272B2/en active Active
- 2012-02-16 CA CA2862798A patent/CA2862798C/en active Active
- 2012-02-16 WO PCT/US2012/025479 patent/WO2012112792A2/en active Application Filing
- 2012-02-16 CN CN201280009550.9A patent/CN103501823B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002010215A1 (en) * | 2000-07-31 | 2002-02-07 | Dabur Research Foundation | Somatostatin analogs for the treatment of cancer |
WO2003042246A2 (en) * | 2001-11-14 | 2003-05-22 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
Non-Patent Citations (2)
Title |
---|
FRANKO-TOBIN, L.G. ET AL.: "Notchl-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics", ONCOLOGIST, vol. 17, no. 2, 30 January 2012 (2012-01-30), pages 220 - 232 * |
KASPERLIK-ZALUSKA, A.A. ET AL.: "'ACTH responses to somatostatin, valproic acid and dexamethasone in Nelson's syndrome'", NEUROENDOCRINOL. LETT., vol. 26, no. 6, 2005, pages 709 - 712 * |
Also Published As
Publication number | Publication date |
---|---|
US9358272B2 (en) | 2016-06-07 |
CN103501823A (en) | 2014-01-08 |
CA2862798A1 (en) | 2012-08-23 |
CN108514638A (en) | 2018-09-11 |
US20140045752A1 (en) | 2014-02-13 |
CN103501823B (en) | 2018-05-04 |
CA2862798C (en) | 2021-04-06 |
WO2012112792A2 (en) | 2012-08-23 |
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