WO2012110964A1

WO2012110964A1 - Method and device for detecting and/or dosing organic compounds in the air

Info

Publication number: WO2012110964A1
Application number: PCT/IB2012/050695
Authority: WO
Inventors: Simon Clavaguera; Alexandre Carella; Jean-Pierre Simonato
Original assignee: Commissariat A L'energie Atomique Et Aux Energies Alternatives
Priority date: 2011-02-17
Filing date: 2012-02-15
Publication date: 2012-08-23
Also published as: FR2971849A1

Abstract

The invention relates to a device and a method for detecting and/or quantifying organic compounds present in a gas. Said device comprises a block protected from the light, for identifying and detecting said organic compound, a device for the transduction, into electrical information, of the information emitted by the identification and detection device, a gas inlet, a device for the pre-treatment and purification of the gas entering via the inlet, a module for the acquisition and processing of the electric signal emitted by the information transduction device, an energy source, and a visual and sound warning system. The invention can be applied to the field of detection and/or quantification of organic compounds, especially organophosphorated compounds.

Description

METHOD AND DEVICE FOR DETECTION AND / OR DETERMINATION OF ORGANIC COMPOUNDS IN AIR

The invention relates to a device for detecting and / or quantifying organic compounds.

It also relates to a method for detecting and / or quantifying organic compounds.

The devices for detecting and / or quantifying organic compounds are composite devices capable of providing a response that alerts, identifies or even quantifies the presence of an analyte. When to detect and / or quantify the analyte, the device is based on a sensitive material having a usable physical property that will allow the detection of an analyte, it is called a chemical sensor.

This sensitive material may be of different natures and have one or more exploitable physical properties.

For this material to be used, it should be deposited in a thin layer on a substrate suitable for the measurements to be made.

Sensor characteristics are often determined using chemically selective materials. The composition as well as the morphology of the thin layer is particularly important since it governs the efficiency of the sensor (selectivity, sensitivity, lifetime, response time, etc.). ■ In addition, the molecular recognition of the analyte the sensitive film is determined by a particular aspect of the film as a ligand or specific functional groups that produce an initial response of a chemical nature. The adsorption or the reaction of target molecules on the sensitive material induces a modification of one of the properties of this material. This chemical information will be converted into electrical information via a transducer most often associated with the substrate on which the sensitive layer is deposited. Thus, the output response of the sensor is an electrical signal interpretable by the user (for example variation of frequency, intensity or voltage). This signal can undergo a treatment which aims to reduce the noise or to reinforce the small variations, which induces a better sensitivity. The user retrieves processed information that directly indicates whether or not there is detection with possible quantification. In addition to their configurable signal processing functions (filters, gains ...), detectors can have other features as self-test and self-check functions or an automatic calibration protocol.

The detection of toxic organic compounds, and particularly the detection of war toxics such as organophosphorus compounds, has become a crucial issue. While laboratory instruments (HPLC, GCMS and others) have excellent sensitivity combined with very good selectivity, there is currently no satisfactory solution for use in the field. A good sensor must be sensitive enough to detect the target at concentrations below the exposure limit, not be subject to environmental factors that would produce false positives such as pressure, temperature, humidity and / or sunshine. Sensors must meet a number of technical and economic criteria such as sensitivity, selectivity, false-positive rate, response time and cost of production and use. In addition, the sensor must be easy to use by unqualified operators, portable and low energy consumption.

There are to date a number of devices based on different chemical, enzymatic or physical technologies for detecting the presence of organophosphorus compounds but each of these devices has serious disadvantages. Such techniques include ion mobility spectroscopy, flame photometry, infrared and Raman spectroscopy, fluorescence sensors, colorimetric indicators, solid state detectors, and the like. See Review of Chemical Warfare Agent Detector Technologies and Commercial-Off-The-Shelf Items, by Rodi Sferopoulos, DSTO-GD-0570 available at http://www.dsto.defence.gov.au/corporate/reports/DSTO-GD -0570.pdf. Some devices that are currently among the most used for the detection of these agents are:

1) Ion mobility spectroscopy

The most common detection technique is probably ion mobility spectroscopy (IMS). The detection principle makes it possible to distinguish ionized molecules according to their masses, charges and mobilities in the gas phase, in the presence of an electric field. The arrival of the ions on the electrical detector generates a characteristic signal which is compared with a database for possible trigger an alarm. The selectivity observed is relatively poor because of the non-discriminating ionization process which leads to many false positives. In addition, environmental effects such as temperature, pressure and humidity can have significant effects on the response of the IMS type detector.

2) Flame photometry

Emission flame photometry is particularly suitable for detecting organophosphorus compounds: the organophosphorus and sulfur derivatives contained in the air each emit radiation of different wavelength after passing through an air-hydrogen flame. The very high sensitivity to any trace of phosphorus or sulfur, that is to say even less than ppm, can be problematic because there are a large number of sources of phosphorus or sulfur in the environment ( exhaust fumes, pesticides, fertilizers, solvents, inorganic sulfur and phosphorus ...).

3) IR and Raman spectroscopies

Physical techniques such as photometry DR. and Raman spectroscopy also give powerful systems, but are difficult to miniaturize and do not meet today the specifications of a nomadic sensor. The main limitations are the cost, the complexity of use and the size of the instrumentation. In addition, the relative humidity can have a strong influence on the response of IR sensors and generate false positives. Finally, these techniques have strong limitations in the case of mixtures containing the analyte of interest with other products.

4) Developing chemical sensors: SAW, Luminescence, enzymatic biosensors, resistors and transistors based on carbon nanotubes

In these methods, it is the sensitive material that determines the sensitivity of the sensor and not the transducer. It is therefore extremely important that the interaction between the sensitive material and the target to be detected is specific to avoid false positives. It is this lack of selectivity that strongly penalizes SAW sensors, resistors and transistors. In the case of biosensors, the detection is done in solution which implies controlling many hard points (variations in pH and salinity, fluidics) and makes the detection in the air very difficult or impossible. In all the In this case, variations in temperature, pressure and humidity can generate many false positives.

5) The sensor described in patent EP 2154525

A group of researchers to which belong some of the inventors claimed, in patent EP 2154525, a device for detecting organophosphorus compounds comprising an electrical device comprising a source electrode and a drain electrode separated by a semiconductor material, characterized in that at least one receptor molecule is grafted on one of the electrodes or on the semiconductor material, and a device for detecting the variation of the positive charges. This detection, although specific, has various disadvantages. First, it requires to be implemented in a low light environment which requires at least a rollover. In addition, semiconductor materials are often sensitive to oxygen, moisture and atmospheric interferents. In addition, highly acidic vapors can generate false positives. Finally, the electronics associated with the operation of such a sensor is bulky (Agilent 4155 device controlled by a computer) which limits the portability of the device.

In summary, the detection devices of organophosphorus compounds currently available have various disadvantages such as a lack of selectivity, sensitivity, a false positive rate too high or too large a size to be portable. Some sensors can only be used to test a sample in solution, others require a low light environment or some are influenced by environmental variations (temperature, pressure, humidity). The main challenges are to improve the reliability of detection by decreasing the false-positive rate. In addition, the sensors must be sensitive enough to detect the target at concentrations below the exposure limit value (ELV) and fast enough to allow for effective warning and to allow for the implementation of adequate safeguards and intervention. fast medical for example.

For this purpose, the invention proposes a detection and / or quantification device, as well as a detection and / or quantification method, which make it possible to identify the presence in a gas, more particularly atmospheric air, of toxic compounds, to provide an indication of their concentrations in the to determine, for example, the level of protection required for a possible response, but also to locate and define the limits of a contamination as well as to determine the effectiveness of a decontamination procedure.

The toxic compound to be detected and / or quantified in the invention is, more preferably, an organophosphorus compound (OPs) - such as organophosphonates, organophosphates, and by extension any organic molecule comprising a phosphorus atom in its chemical structure - belonging to a family of molecules with a wide range of toxicity, including harmful compounds to chemical weapons acting on the central nervous system such as Sarin, for which the lethal concentration and time LC _t5 Q is 100mg.min. Tabun or the Soman. These innervating agents represent one of the most important lethal classes of chemical weapons. OPs are potent inhibitors of serine proteases and more particularly of acetylcholinesterase, which plays a critical role in synaptic communication. Given the lethality of these chemical weapons, their availability, and their relatively easy synthesis, the POs are of interest to terrorists (Sarin bombing, Tokyo Metro, 1995). Thus, the rapid detection of such compounds has become a crucial societal issue and the subject of important research. In addition, the quantification of traces of OPs is extremely important in the context of the protection of the environment and people in particular for the control and monitoring of the quality of air, water or agri-food products.

The invention is not limited to the detection of organophosphorus compounds alone. It is designed to be adaptable to other analytes by taking care before using a suitable sensitive material.

For this purpose, the invention proposes:

a method and a device for detecting and / or measuring traces of toxic volatile compounds, in air not having the difficulties mentioned above,

an extremely sensitive device capable of detecting traces of toxic volatile compounds at concentrations below their TLV,

an extremely selective device capable of detecting traces of analyte in a complex mixture of gases, a device capable of detecting traces of toxic volatile compounds in the air without being influenced by environmental parameters such as temperature, pressure, humidity or brightness,

- a device that is portable, autonomous and robust so that it can be used by unqualified personnel in the field,

- a device to detect the target very quickly, and thus reduce the analysis time, without compromising the quality of measurements.

For this purpose, the invention proposes a device for detecting and / or quantifying traces of at least one organic compound present in a gas comprising:

a block comprising a zone for recognizing and detecting said organic compound, and

a device for transducing, in electrical information, the information emitted by the zone of recognition and detection of said organic compound,

characterized by further comprising:

- a gas inlet,

a device for pretreatment and purification of the gas entering through the inlet,

a module for processing the electrical signal emitted by the information transduction device,

- a source of energy,

- a visual and audible warning system,

and in that the transducer is shielded from electromagnetic waves.

Preferably, the device according to the invention further comprises:

a gas flow control module entering the block comprising the zone for recognizing and detecting organic compounds,

- a gas evacuation pump,

- a gas evacuation vent,

and a Faraday cage cover, surrounding the entire device for detecting and / or quantifying traces of at least one compound organic and protecting the block comprising the recognition and detection zone of the organic compound of the electromagnetic waves.

More preferably, it further includes:

- a memory card, and

- a communication port with a laptop or a key

USB.

In a preferred embodiment, the recognition and detection block is a field effect transistor comprising:

a zone for recognizing and detecting organic compounds comprising at least one compound R having a specific reaction with the organic compound to be detected,

an intermediate layer made of a dielectric material,

a source electrode placed on the intermediate layer,

a drain electrode placed on the intermediate layer,

a layer made of a semiconductor material placed on and in contact with the intermediate layer and between the source electrode and the drain electrode and in contact with these electrodes,

a gate electrode placed under and in contact with the intermediate layer,

a device for measuring the intensity of the current _{DS being} flowing between the drain electrode and the source electrode, and

- A voltage generator for applying a variable voltage V _G s between the gate electrode and the source electrode.

Preferably, in this embodiment, the layer made of a semiconductor material is doped or undoped silicon nanowires or nanoribbons, preferably etched in the surface layer of a "silicon on insulator" (SOI) assembly.

The SOI is an assembly comprising a superposition of 3 layers: a thick silicon layer coated with an oxide layer itself coated with a very thin silicon layer (about 100 nm). The doped or undoped silicon nanowires or nanoribbons are etched in the thin layer of silicon. Also preferably, the organic compound to be detected is an organophosphorus compound of formula (II) below:

(W ^ PLVL ³

in which :

- W is O or S, and

at least one of the groups L ¹ L ² L ³ is a leaving group,

and in that the zone comprising at least one compound R is a monomolecular layer of organic receptor molecules comprising receptor groups of formula (I) below:

(I)

Formula I

in which :

-n = 0, 1 or 2

X is a group capable of reacting with the organophosphorus compound to be detected in order to form an intermediate group -Z, X being preferably chosen from -CH ₂ OH, -CH ₂ NH ₂ , -C¾SH groups;

Y is a group capable of reacting with the -Z group to form a ring bearing a positive charge, Y being a nucleophilic function chosen from a tertiary amine or an aromatic amine, an ether or a thioether.

Preferably, the receptor group has the following formula:

- A-L-X

in which :

A is a group comprising a function Y as defined above,

L is a group - (CH ₂ ) _n , where n is an integer between 0 and 6 inclusive, preferably between 0 and 2 inclusive,

X is as defined above, preferably X is -CH ₂ OH, and A is a group comprising a tertiary amine, preferably a nitrogen-containing C ₃ to C ₆ heterocycle, more preferably a C ₃ to C ₆ heterocycloalkyl or a C ₃ to C ₆ heteroaryl containing nitrogen.

Preferably, the organic receptor molecule has a receptor group of the following formula IV

(IV)

Form IV

In all embodiments of the device of the invention, the organic receptor molecules are grafted onto the layer of a semiconductor material.

But, the organic molecules can be grafted onto at least one of the source or drain electrodes only, possibly in addition to the grafting on the layer of a semiconductor material.

The invention also proposes a method for the detection and / or quantification of traces of at least one organic compound in a gas, characterized in that it comprises introducing the gas into the device according to the invention.

Preferably, in the method of the invention, the device in which the gas is introduced is a device according to the preferred embodiment.

In this case, the method of the invention further comprises a step of recording the change in the intensity of the current flowing between the source electrode and the drain electrode as a function of the voltage V _GS applied between the source electrode and the gate electrode.

Still in this case, preferably, the method of the invention comprises the following steps:

a) detection and recording of the variation of the electrical intensity

\ _{D $} for a fixed V _DS voltage applied between the source electrode and the drain electrode, depending on the voltage V _GS during the introduction into the detection and / or quantification of a gas comprising no compound to detect, b) determining the lowest current IOFF and voltage Vos corresponding to the lowest current obtained in step a) and,

c) applying the voltage V _GS (I _OFF ) between the gate electrode and the source electrode and detecting the variation of the current I _D S in the presence of the gas suspected of containing the organic compound.

In a particular mode of implementation, the voltage VGS (I _OFF ) applied to step c) is equal to 0 and the detection of the variation of the current IDS is of the resistor type.

However, the method of the invention may also comprise the detection and recording of the voltage variation V _GS , when the current ¾s is kept constant during the passage of the gas suspected of containing the organic compound.

In all cases, the voltages applied between the source electrode and the drain electrode, Vos and VGS, are chosen from the group comprising DC voltages, pulsed voltages and AC voltages.

The invention will be better understood and other characteristics and advantages thereof will appear more clearly on reading the explanatory description which follows and which is given with reference to the appended figures in which:

FIG. 1 is a schematic representation of a device for detecting and / or quantifying organophosphorus compounds, according to the invention,

FIG. 2 is a diagrammatic representation of the recognition and detection device, connected to the information transducing device emitted by the recognition and detection device, of the device represented in FIG.

FIG. 3 represents, in flowchart form, the steps of the method for detecting and / or quantifying organic compounds, according to the invention,

FIG. 4 shows the variation curves of the intensity between the drain electrode and the source electrode of the recognition and detection device according to the invention, as a function of the voltage variation applied between the gate electrode and the source electrode during the introduction into the device of the invention of air or air containing the organophosphorus-diphenyl chlorophosphate compound, DPCP,

FIG. 5 represents the variation of the intensity of the current flowing between the drain and source electrodes of the recognition and detection device of the DPCP according to the invention as a function of the time of exposure to air and then to air contaminated with 100 ppb of DPCP

FIG. 6 represents in schematic form the container used in example 5.

One embodiment of the device for detecting and / or quantifying trace amounts of at least one organic compound in a gas, preferably air, is shown in FIG.

As seen in FIG. 1, the device for detecting and / or quantifying traces of at least one organic compound in a gas, according to the invention comprises at least the following elements:

a block, denoted 6 in FIG. 1, comprising a zone, denoted 10 in FIG. 1, of recognition and detection of said organic compound, and a device, noted 23 in FIG. 1, for the transduction of the information transmitted by zone 10, in electrical information,

an inlet, denoted 2 in FIG. 1, of the gas, in particular of the gas suspected of containing the organic compounds,

a device, noted 4 in FIG. 1, for pretreatment and purification of the gas flowing in the detection and / or quantification device of the invention,

an assembly, denoted 22 in FIG. 1, comprising modules, denoted 16, 17 and 18 in FIG. 1, of acquisition and processing of the electrical signal emitted by the transduction device 23,

a source of energy, not shown, and

a system, noted 19 in FIG. 1, for visual and audible warning.

However, preferably, the device for detecting and / or quantifying traces of at least one organic compound according to the invention further comprises:

a module, denoted 3, for controlling the temperature of the gas, entering the inlet 2,

a device, noted 5 in FIG. 1, for controlling the flow rate of the gas entering the device 6 for recognizing and detecting organic compounds,

a pump, denoted 7 in FIG. 1, for evacuation of the gas,

a vent, denoted 8 in FIG. 1, of evacuation of the gas, a cover, denoted 9 in FIG. 1, forming a faraday cage and surrounding the entire device for the detection and / or quantification of traces of at least one organic compound of the invention, and protecting electromagnetic waves and impurities block 6 and in particular the zone 10 for detecting and recognizing organic compounds to be detected and / or quantified.

The detection and / or quantification device of the invention may further comprise a memory card, denoted 20 in FIG. 1, and a communication port, denoted 21 in FIG. 1, with a laptop computer or a USB key.

Block 6 for recognizing and detecting organic compounds is a field effect transistor which comprises:

an area, denoted 10 in FIG. 1, comprising at least one compound X having a specific reaction with the organic compound to be detected,

an intermediate layer, denoted 14 in FIG. 1, made of a dielectric material,

a source electrode, denoted 11 in FIG. 1, placed on the intermediate layer 14,

a drain electrode, denoted 12 in FIG. 1, placed on the intermediate layer 14,

a layer, denoted 13 in FIG. 1, of a semiconductor material placed on and in contact with the intermediate layer 14 and between the source electrode 11 and the drain electrode 12 and in contact with these electrodes,

a grid electrode, noted in FIG. 1, grid placed under and in contact with the intermediate layer 14.

The semiconductor material constituting the layer 13 may be based on silicon, germanium, boron, zinc, gallium, arsenic or carbon.

Preferably, the layer 13 is made of nanowires and / or doped or undoped silicon nanoribbons.

More preferably, the layer 13 will be in silicon nanowires and / or silicon nanoribbons etched into the surface layer of an SOI (Silicon On Insulator) assembly.

The source electrodes 11 and drain 12 may be metallic, for example gold, silver, palladium, platinum, titanium, doped silicon, copper, nickel, chromium with or without silicided contacts or based on a carbonaceous material.

The field effect transistor, that is to say the block 6, is protected from electromagnetic waves, more particularly from the external light by a cowling, denoted 9 in FIG. 1, which can also play a Faraday cage role if this cowling is metallic.

This confers a twofold interest on the device and the method of the present invention, on the one hand by limiting the photoelectric effects caused by the external lights on the transistor and on the other hand, by protecting the sensor from electromagnetic fields or electrostatic discharges susceptible to disturb the measurement of a very weak current (high impedance).

The simple structure of this field effect transistor allows low cost and large scale production of the device of the invention.

In addition, because of this simple structure, the device is very small and requires little energy to operate. This device can be portable and autonomous.

In the invention is meant by portable and autonomous energy detector, an integrated device that has all the elements for its proper functioning and whose size and weight can easily move or transport. For example, it will be of a weight of less than 500 g and preferably of a volume of less than 500 cm ³ or preferably of a weight of less than 200 g and a volume of less than 200 cm ³ .

Even more preferably, it will have a weight of less than 10 g and a size of less than 10 cm ³ .

The molecular recognition zone, or sensitive zone, is responsible for the sensitivity and selectivity of the detector to a particular family of toxic volatile compounds. In the case of the detection and / or quantification of organophosphorus compounds, this sensitive zone 10 corresponds to a monomolecular layer grafted on the semiconductor material and / or on at least one of the electrodes of the field effect transistor. This layer is composed of organic receptor molecules corresponding to the general chemical structure described in the patent EP 2154524 in reference. The organic receptor molecule, comprising a receptor group, denoted (I) in the following scheme 1, reacts with organophosphorus compounds of general structure, denoted (II) in the following Scheme 1 to form in two stages a cyclized product, noted ( III) in the following diagram 1, carrying a positive charge.

This reaction is represented in the following Scheme 1:

Diagram 1.

The receptor group (I) taken in isolation has two chemical functions:

an X function capable of reacting with the organophosphorus compound to be detected to form an intermediate group -Z, X being chosen from -CH ₂ OH,

- CH ₂ NH ₂ , -CH ₂ SH; and

a Y function capable of reacting with said -Z group to form a ring bearing a positive charge, Y being a nucleophilic function chosen from a tertiary amine or an aromatic amine, an ether or a thioether.

Within the meaning of the present invention, the organophosphorus compounds II are compounds of formula (W =) PL LL, in which W is O or S and at least one of the groups L ¹ , L ² , L ³ represents a leaving group .

By "leaving group" is meant a leaving group, nucleofuge, that is to say a group capable of being substituted by a nucleophilic group during a nucleophilic attack. As examples of leaving groups, mention may in particular be made of halogen atoms, in particular bromine, chlorine and fluorine atoms, and the groups AlkO-, AlkS-, where Alk represents a branched or unbranched alkyl group comprising from 1 to 6 carbon atoms, and ArO-, ArS- groups where Ar represents a substituted or unsubstituted aryl group. The exposure of the receptor group to an organophosphorus compound leads to the formation of a nucleophilic intermediate group -Z, resulting from the nucleophilic substitution of an L ³ labile ligand on the phosphorus atom by the nucleophilic function X.

Z can thus be a phosphate, phosphoramidate or thiophosphate group, that is to say a group resulting from the formation of a covalent bond - O-P (= O), -NP (= O), -SP ( -O) respectively.

It follows an intramolecular nucleophilic attack by the Y function (ether (-O-), thioether (-S-) or tertiary amine (-N-)), on the carbon atom of the receptor group carrying the Z function. (-O-P (= O), -NP (= O), -SP (= O)), to result in the formation of a cyclized compound having a positive electronic charge localized on the N, O or S heteroatoms of the function Y.

By "Y-function capable of reacting with said -Z group to form a cycle carrying a positive charge", it is understood that the X and Y functions of the receiver group are in spatial proximity to one another, so as to allow intramolecular cyclization.

Preferably, the reaction of the nucleophilic function Y on the group -Z leads to the formation of a 5- to 7-membered ring.

Preferably, the receptor group is a group of formula -ALX in which A is a group comprising a function Y, and L is a group - (CH ₂ ) n -, where n is an integer of 0 to 6. More preferably, n is an integer from 0 to 2.

Preferably, X is -CH ₂ OH.

Preferably, A is a group comprising a tertiary amine, including a nitrogen heterocycle, especially a heterocycloalkyl, C ₃ -C ₆ or an aromatic amine as a heteroaryl C ₃ -C ₆ nitrogen.

Preferably, the group group of formula (IV) below:

(IV)

The sensitive zone 10 corresponds to a multitude of grafted receptor groups of formula (IV) forming a mono-molecular layer on a semiconductor material and / or on at least one of the electrodes of the field effect transistor.

However, the organic receptor molecules can also be grafted onto at least one of the electrodes 11, 12.

Preferably, the organic receptor molecules are grafted onto the layer 13 of a semiconductor material.

As for the transduction device 23, in electrical information, it makes it possible to translate a chemical information (the organophosphorus compound reacted with at least one of the receptor molecules) into information of an electrical nature that is easy to process and interpret. Indeed, when the reaction takes place between an organophosphorus molecule and the surface-grafted receptor, the reaction product is a salt having a cation and an anion. The formation of this salt strongly modifies the electrical properties of the semiconductor material 13 on which is grafted the sensitive single-molecule layer or zone 10. It is therefore the follow-up of one or more of the electrical properties of the semiconductor material. which will inform about the detection of organophosphorus compounds.

The present invention provides a low gate-type field effect transistor architecture in which the semiconductor portion 13 is separated from the gate electrode 15 by a dielectric material 14. The semiconductor material 13 which acts as the conduction channel is a semiconductor material, preferably based on silicon, germanium, boron, zinc, gallium, arsenic or carbon. Preferably, the semiconductor material 13 consists of doped or undoped silicon nanowires or nanoribbons. More preferably, the semiconductor material 13 is made of silicon nanowires or silicon nanoribbons etched into the surface layer of an SOI (Silicon On Insulator) assembly. The source electrodes 11 and drain 12 may be metallic, for example gold, silver, palladium, platinum, titanium, doped silicon, copper, nickel, chromium with or without silicide contacts or based on carbonaceous material. The field effect transistor is protected from the external light by a cowling 9 which can also act as a Faraday cage if the envelope is metallic. This confers a double interest on the present invention, on the one hand by limiting the photoelectric effects caused by the external light on the transistor and It also protects the sensor from electromagnetic fields or electrostatic discharges that may disturb the measurement of very low currents (high impedances).

The simple structure of this field effect transistor allows low cost and large scale production. In addition, because of this simple structure, the device is very small and requires little energy to operate. In addition, the field effect transistor coated with a single-molecule layer of specific receptors Panalyte can be disposable (single use) because of the low production cost of the latter.

The drain electrodes 12 and source 11 are connected to the terminals of an electrical circuit consisting of a power supply and a device for measuring the intensity of the current flowing between the drain electrode 12 and the source electrode 11. , which will be referred to as I _D s- This electric circuit, which is the transducing device 23 is shown in Figure 2. the power supply can provide for example a DC voltage, AC, pulse, or a voltage ramp . The gate electrode 15 is, for its part, connected to a power supply that makes it possible to vary the gate-source voltage VGS. This gate electrode can also be connected directly to the ground or to a zero potential, which amounts to use the semiconductor between the drain electrode and the source electrode as a resistor (VGS ™ 0V). In the present invention, the use of a resistor is contemplated as a particular case of transistor use.

The field effect transistor is connected to an I _DS measuring device. This measuring device is a device that measures the intensity IDS after applying a drain-source voltage VDS and a gate-source voltage Vos, while a gaseous stream loaded with analyte is in contact with the sensitive zone 10 The voltages Vos and VGS generally applied are chosen from the group consisting of DC voltages, pulsed voltages and AC voltages.

As seen in FIG. 2, the transducer 23 of the signal (ie field effect transistor) according to the invention comprises an electric circuit for applying and / or varying the voltages Vos and VGS and measuring the intensity of the current IDS which flows between the drain and the source of the transistor when the sensitive zone is subjected to the influence of the gaseous analyte. The invention also relates to a method for detecting and / or measuring the concentration of at least one constituent analyte of a gas mixture analyzed by the detector. This process may require:

(a) record changes in transfer characteristics

over time and using appropriate signal processing, identify variations caused by the presence of the analyte.

In the invention, it has been possible to demonstrate that such a field effect transistor has a transfer characteristic lDS = f (Vos) of type p, of type n or sometimes of ambipolar type. The transfer curves may be recorded before and after exposure of the gas-flow sensitive zone or these transfer curves may be recorded at regular time intervals throughout the exposure of the gas-flow sensitive zone. These transfer curves are modified by the exposure of the analyte sensitive zone. More particularly, the monitoring of the electrical parameters, such as the mobilities, the slopes below the threshold, the threshold voltages or the current levels I _ON and IO _FF> ui can be extracted from the transfer curves, is relevant.

b) either to work at fixed voltage Vos and to monitor the evolution of current I _DS over time.

In one embodiment of the method according to the invention, the first step consists of recording a transfer curve for a fixed voltage Vos. The analysis of this curve lDs ⁼ f (os) by a suitable signal processing makes it possible to determine the lowest current level called I _OFF and the voltage Vos the smallest corresponding to this level I _OFF , called voltage VQ _S (I _OFF ) - This voltage, thus determined, V _GS (I _OFF ) is close to the value of the threshold voltage, these values can in some cases be confused. The second step is after the previous learning phase, to apply this voltage V _GS (I _OFF ) and monitor the evolution of the current IDS during the exposure of the gas-sensitive zone. In the particular case where the voltage V _GS (I _OFF ) is zero (equal to 0V), the detection is carried out in resistor mode. In the present invention, the use of a resistor is contemplated as a particular case of transistor use. When the analyte appears in the gas stream between a first instant and a second instant following said first instant, it is possible to determine the presence and possibly the concentration of the analyte at the second instant. For this purpose, the value of the intensity of the current flowing through the semiconductor between the drain electrode and the source electrode at the first instant is compared with the value of the intensity of the current flowing through the semiconductor at second moment. When the difference is greater than a reference value depending on the analyte, the alert procedure can be initiated. The analysis of this current difference traversing the semiconductor between the drain electrode and the source electrode between the first and second instants by a suitable signal processing and taking into account the air flow as well as the time elapsed between said first and second instants, makes it possible to determine the concentration of the analyte in the gas stream.

Preferably, this difference is determined as follows:

V _GS (I _OFF ) is determined, as described above, - Then 2V is subtracted from this value of V _GS (I _OFF ) and the value of the intensity of the current (IDS) associated with this voltage is taken ( V _GS (I _OFF ) -2V) on the curve (¾s ⁼ Î (VGS)) - This current value is the value of the threshold above which the alert is triggered.

In another alternative embodiment of the method according to the invention, a value of the time derivative of the intensity of the current flowing between the drain electrode and the source electrode of the transistor between the first and the second phase is calculated. and second moments.

In another alternative embodiment of the method according to the invention, a voltage slot is applied over a period ranging from zero to a few seconds between the drain electrode and the source electrode of the transistor, while the intensity of the current flowing between the drain electrode and the source electrode of the transistor is measured according to a previously chosen sampling. The analysis of the variations of the current by an appropriate signal processing taking into account the sampling used makes it possible to identify the presence of the analyte in the gas stream and possibly to go back to its concentration.

In another alternative embodiment of the method according to the invention, a first voltage is applied between the first and second instants, a second voltage, different from the first voltage, is applied between the second and third instants, these steps being repeated periodically in the time and the Fourier transform of the signal delivered by the detector being carried out, it is possible to determine the presence of the analyte in the gas stream and possibly to go back to its concentration.

c) to maintain a stable current et> s and to follow the evolution of the voltage Vos

In one embodiment of the method according to the invention, the current

I _DS traversing the semiconductor between the drain electrode and the source electrode is kept constant by varying the voltage V _GS - Monitoring the evolution of this voltage Vos during the exposure of the sensitive area to the gaseous flow makes it possible to determine the presence of the analyte and possibly to go back to its concentration by using a suitable signal processing.

In each of these three cases, the voltages Vos and VQ _S are chosen from the group consisting of DC voltages, pulsed voltages and AC voltages.

Preferably, the measurements made are repeated successively a plurality of times and the warning signal is initiated when successively several measurements are conclusive as to the detection of the analyte in the gas stream.

A) Electrical signal acquisition and processing module The electrical circuit as well as the application of the voltages and the measurement of the currents are realized by a microcontroller which performs an analog / digital conversion of the value of the measured current and which comprises inter alia a clock, counters, and a prerecorded program for delivering a measurement signal at regular or irregular intervals. If necessary, the microcontroller is capable of processing the evolution of measurements over time. These signal processing techniques are of known type.

It is important that the electronic components used are insensitive to temperature variations and if there is a low temperature dependence, appropriate correction will be made during signal processing. In addition, the electrical circuit is suitable for the measurement and treatment of extremely low currents. The electronic components, the insulating materials (resins, sheaths ...) as well as an electromagnetic shielding of the device (faraday cage) make it possible to have a good measuring precision for a very wide range of current B) Visual and audible warning / buzzer and light + RF transmitter

The modification of the electrical parameters of the transistor is analyzed by the microcontroller and the corresponding information is sent to the alert elements (beep, LED, LCD display and possibly RF transmitter). The conventional measurement acquisition time for detecting the presence of the analyte varies from 1 to 10 seconds, preferably from 1 to 5 seconds. In some cases, detection can be done in less than one second.

C) Source of energy

Potentially the energy source of the accumulator type can be recharged alone by means of photovoltaic systems, fuel cell or other.

D) Pre-treatment / chemical purification zone, said filter accompanied by a pump for circulating the air to be analyzed in the detector

The device for detecting and / or quantifying organic compounds according to the invention comprises an air pump 7 which makes it possible to circulate a potentially charged air stream in an analyte from the outside through the inlet 2 to the measurement block 6 where is the sensitive area of the detector then to evacuate this flow to the output 8. The measurement block 6 comprises the functionalized field effect transistor 23 electrically connected to the acquisition and processing module of the signal 22. 6 is designed so that the gaseous stream loaded analyte passes to the surface or across the sensitive zone 10 so that there is contact between the analyte present in the flow and the sensitive molecules grafted to the surface of the sensor. In addition, a flowmeter 5 may be used to control the flow rate of the pump 7. The flowmeter 5 and the pump 7 may also be connected to the microprocessor to establish a constant flow through the detector. The rates applied usually are of the order of 30 to 300 cm ³ / min. However, any flow can be used continuously, sporadically, or at regular time intervals. The detector may comprise a pretreatment zone 4, called a filter, positioned upstream of the sensitive zone. This filter 4 makes it possible to trap the acid vapors likely to generate false positives. This filter is made of basic material. It can be for example and non-exclusively in the form of compacted pellets, powder, a phase supported on a resin or compounds impregnated in a porous material. In all cases, the filter allows a passage of gas flow through it and selectively adsorbs acid traces. Among the basic materials constituting the active part of the filter according to the invention, can be used in particular inorganic bases such as sodium, calcium, magnesium, potassium or ammonium hydroxides, calcium carbonates, magnesium, sodium or potassium, potassium t-butoxide, sodium ethanoate, sodium methanoate, metal oxides such as oxides of zinc, magnesium, barium, calcium, strontium, cerium, lanthanum or beryllium, basic alumina, supported alkali fluorides including potassium fluoride on alumina, mixed oxides, treated zeolites, grafted silicas, hydrotal cites, Lewis bases such as pyridine, triethylamine, quinoline as well as combinations of these different bases or derived materials and any species that dive in pure water (pH = 7) increases the pH thereof.

In addition, a temperature control module can be introduced upstream of the sensitive zone to determine the temperature of the fluid arriving in the detector. This module can optionally heat up the air flow to the optimum operating temperature.

Surprisingly, the method and the device for detecting and / or measuring traces of organic compounds in the air makes it possible to detect sub-ppm traces of toxic organic compounds and more particularly of organophosphorus compounds in the air without suffering from false alarms caused by changes in humidity, temperature or brightness. This performance is all the more exceptional as the operation of the integrated detector has been validated up to 95% relative humidity over a temperature range of 0 to 60 ° C. Indeed, one would have expected to observe a decrease in sensitivity, and a decrease in the selectivity for high humidity levels and an increase in the rate of false alarms at operating temperature limits.

In order to better understand the invention, several modes of implementation will now be described.

One embodiment of this invention is the use of a device for detecting or measuring traces of organic compounds in the air to detect in particular the organophosphorus compounds. In the examples that follow, the fabrication of the functionalized field effect transistor will be particular for the purpose of detecting traces of organophosphorus compounds in the air.

The various steps necessary to operate the device according to the invention and specifically detect the organophosphorus compounds (OP) are shown in flow chart form in FIG.

EXAMPLE 1 Preparation of the Field Effect Transistor, Functionalization with a Selective Receptor of Organophosphorus Compounds and Connection to the Detector's Electronic Circuit Detection test of 100 ppb of an organophosphorus compound, diphenylchlorophosphate (DPCP), in air at 20 ° C with a relative humidity of 32%.

A silicon nanowire field effect transistor is prepared from a p-doped SOI wafer (10 ¹⁵ atom / cm ³ ). The silicon wire of dimensions 70 nm in thickness, 0.2 μηι in width and 2 μηι in length is obtained by electron lithography and ion beam etching ("ion etching"). The thickness of the dielectric material (Si0 ₂ ) is 140 nm. The Ti / Au (10/100 nm) source and drain electrodes are produced by electronic lithography and lift-off. The degenerate silicon substrate is used as the gate electrode.

The preparation of a specific mono-molecular layer of the organophosphorus compounds is carried out by thermal hydrosilylation. A solution of the compound (V) in mesitylene at a concentration of 10 ^-3 mol / l is prepared under argon. The chip, previously treated with an aqueous solution of 1% hydrofluoric acid, is introduced into the reaction medium. After 2 hours of reaction at a temperature of 10 ° C., the chip is rinsed with toluene, acetone and ethanol and then dried under vacuum.

The compound (V) has the following formula:

(V)

The three electrodes of the transistor are connected by bridging (source and drain electrodes) and by contact recovery using silver lacquer. rear face (gate electrode) on a "daughter board" itself connected to the printed circuit by a matrix of pins.

When the "daughter board" is connected to the circuit board and the detector is turned on. The latter records a transfer curve of the transistor by fixing the voltage Vos at -1 V and measuring the current I _DS as a function of the voltage V _GS between -20 V and + 20V. This curve is stored in memory then analyzed to determine the level I _OFF and the lowest voltage associated with this level IOFF: VGS (IO _F F). As seen in Figure 4, the IOFF level is 2x10 ^{~ 12} A and VQS (IOFF) of 7 V, in the context of this example.

The learning phase is completed from the moment when the voltage VGS (IOF _F ) is determined. At this point, the detector has two modes of operation:

- the tracking of the transfer curves over time

or the follow-up over time of the intensity of the current I _DS associated with the voltage V _gs (IOFF)

The detector is also able to perform both treatments in parallel by switching from one mode to another alternately at regular time intervals.

In the present example, the monitoring of the intensity of the current I _D S associated with the voltage Vos (IOFF) was chosen. This intensity is stable when the sensitive zone is swept by a clean air flow (flow of 300 cm ³ / min). On the other hand, a sharp and sharp increase appears when the gaseous stream is charged with vapors of an organophosphorus compound, diphenylchlorophosphate (DPCP) at a concentration of 100 ppb (1 mg / m ³ of air). By means of an appropriate signal processing method, the detector switches to alarm mode as soon as the intensity I _D S crosses a particular threshold value, which corresponds to the intensity I _DS of Vos (I _OFF ) -2V , and stays on top for 3 seconds, which occurs at time t = 133 seconds as shown in Figure 5. Therefore, the microprocessor activates the alarm signals (flashing LEDs, beep, and line text indicating the alert status on the LCD). A detection signal is also sent by the RF transmitter to signal the state of alert to an RF receiver located a few meters. Once the alert state is activated, the detector records a transfer curve. The latter is shown in dashed lines in FIG. Since the detector does not have a curve display, only the value of the current IDS current appears as a line of text on the LCD screen together with information on the detector status: "Nothing to report "when the flow of air is clean," Alarm "when the presence of traces of DPCP is identified.

EXAMPLE 2 Preparation of the Field Effect Transistor, Functionalization with a Selective Receptor of Organophosphorus Compounds and Connection to the Electronic Circuit of the Detector Detection test of an organophosphorus compound, diphenylchlorophosphate (DPCP), in air at different temperatures 5, 20 and 50 ° C.

The temperature range for the proper functioning of the device is defined in particular by the electronic components of the latter. According to the supplier data of these components, the optimal operating range is 0 to + 60 ° C. The operation of the detector was therefore tested at different temperatures (5, 20, and 50 ° C) for DPCP concentrations corresponding to its vapor pressure at the chosen temperature.

In this example, the phase of preparation of the field effect transistor, its functionalization and its connection to the electronic circuit of the detector is identical to that presented in example 1. Three transistors were prepared to carry out detection tests at 5 °. C, 20 ° C and 50 ° C.

The tests are carried out in a thermostated chamber in which the device is introduced and a vial containing the DPCP.

For each test, the detector is turned on and the IDS current is measured for 5 minutes while the sensitive zone is swept by a clean air flow at a flow rate of 300 cmVmin. After these 5 minutes, the vial containing the DPCP is opened and the air inlet of the detector is positioned near the opening of the vial to allow the vapors to be aspirated by the detector.

When tested at 5 ° C, during the first 5 minutes under clean air, no false positives are observed. After exposure to DPCP vapors, the detector is able to identify the presence of organophosphorus compounds after an exposure time of less than ten seconds.

The triggering of the state of alert described in Example 1 is similarly observed for the test carried out at 20 ° C. Finally, when the test is carried out at 50 ° C, the alarm is triggered extremely rapidly (<2 seconds) after exposure to a flow of air charged with DPCP vapors without generating a false positive during the five minutes of scanning. clean air.

In conclusion, the detector detected in all cases the presence of DPCP vapors rapidly in the air flow without creating false alarms during the period when the sensitive zone was subjected to a clean air flow.

EXAMPLE 3 Preparation of the Field Effect Transistor, Functionalization with a Selective Receptor for Organophosphorus Compounds and Connection to the Electronic Circuit of the Detector Detection test of an organophosphorus compound, diphenylchlorophosphate (DPCP), in air at different temperatures 20 ° C for different relative humidity levels (<1%, 32% and 76%).

In this example, the phase of preparation of the field effect transistor, its functionalization and its connection to the electronic circuit of the detector is identical to that presented in example 1. Three transistors have been prepared to perform detection tests for different rates. humidity. The air flow whose relative humidity is less than 1% comes from a bottle of synthetic dry air (liquid air: N ₂ 80%, 0 ₂ 20%, H ₂ 0 <3 ppm). The tests carried out at 32 and 76% relative humidity were carried out respectively on a good day and a rainy day when the relative humidity was measured using a hygrometer. In all three cases, the air temperature during the tests was 20 ± 3 ° C.

For each test, the detector is turned on and the IDS current is measured for 5 minutes while the sensitive zone is swept by a clean air flow at a flow rate of 300 cm ³ / min. After these 5 minutes, a vial containing the DPCP is opened and the air inlet of the detector is positioned near the opening of the vial to allow the vapors to be aspirated by the detector.

Example 1 corresponds to the test carried out at 32% RH and is therefore conclusive when detecting traces (100 ppb) of DPCP. The dry air test does not show a false positive during the five minutes of scanning of the sensitive area by the clean air flow, and the detector identifies the presence of organophosphorus compounds in less than five seconds after the opening of the flask. In the presence of moist air (rainy day, 76% humidity, 22 ° C) the sensor does not present false positive during the five minutes clean air sweep and triggers the alarm in less than ten seconds when exposed to DPCP vapors.

EXAMPLE 4 Preparation of the Field Effect Transistor, Functionalization with a Selective Receptor for Organophosphorus Compounds and Connection to the Detector's Electronic Circuit Exposure of the sensor to interfering vapors (solvents, acids, bases and commercial detergents).

In this example, the phase of preparation of the field effect transistor, its functionalization and its connection to the electronic circuit of the detector is identical to that presented in Example 1. Several transistors have been prepared to perform the exposure tests at the same time. interfering vapors.

For each test, the detector is turned on and the IDS current is measured for 5 minutes while the sensitive zone is swept by a clean air flow at a flow rate of 300 cm ³ / min. After these 5 minutes, a vial containing the interfering compound to be tested is opened and the air inlet of the detector is positioned near the opening of the vial to allow the vapors to be aspirated by the detector.

Each of the following compounds was tested on the detector at room temperature:

- Ethyl acetate - Toluene

- Acetone - Ammonia

- Acetonitrile - Acetic acid

Cyclo Exane - Propionic Acid

- Dichloromethane - Ajax® glass

- Ethanol - Soupline®

Water - Façonnable® Eau de Toilette

Iso-propanol - Motor spirit

- N-methyl pyrrolidone - Whiteboard cleaner

- Pentane

The above products have been tested multiple times on different chips and have never triggered an alarm. No false positives were observed during the five minutes of clean air sweeping or exposure to the vapors of the potential interferents tested. It is important to note that the sensor is not disturbed (no alarm) by exposure to acid vapors (acetic acid and propionic acid), although it might have been thought that such compounds could alarm.

The good state of each of the transistors used was tested by exposing them to DPCP vapors at the end of the experiment. All transistors, without exception, triggered an alarm when exposed to the DPCP.

EXAMPLE 5 Preparation of the Field Effect Transistor, Functionalization with a Selective Receptor for Organophosphorus Compounds and Connection to the Detector's Electronic Circuit Sensor exposure to a complex mixture containing traces of organophosphorus compounds.

In this example, the phase of preparation of the field effect transistor, its functionalization and its connection to the electronic circuit of the detector is identical to that presented in example 1. Two transistors have been prepared to perform the exposure tests to a single detector. complex mixture containing traces of organophosphorus compounds.

For the purposes of the experiment, a container consisting of two bottles arranged one inside the other, as shown in Figure 6, is prepared. The largest bottle, noted 27 in Figure 6, contains a liquid, noted 24 in Figure 6, which may be gasoline or perfume, while the smallest bottle, noted 26 in Figure 6, located in the center the larger one contains the DPCP, noted in FIG. 6, so that the liquids are not in contact but their vapors are mixed. The system is thus prepared, capped for 30 minutes so that the vapors are balanced before the start of the exposure.

For each test, the detector is turned on and the IDS current is measured for 5 minutes while the sensitive zone is swept by a clean air flow at a flow rate of 300 cm ³ / min. After these 5 minutes, the container consisting of the two bottles is open and the air inlet of the detector is positioned near the opening of the container to allow the vapors to be sucked by the detector.

In the presence of gasoline for engine and DPCP, the sensor responded positively by triggering the alarm. In the presence of perfume and DPCP (similar experiment to the previous one but where the essence was replaced by perfume), the sensor also detected the presence of organophosphorus compounds.

These two experiments highlight the high sensitivity of the detector as well as its selectivity when the air is polluted by several components including analyte to detect. In this case, the analyte is distinguished in the mixture whereas, as shown in Example 4, the sensor does not raise an alarm when it is exposed only to gasoline or perfume vapors .

The invention is placed in a strong industrial and scientific context since the demand for chemical gas sensors has grown significantly in recent years. The built-in robust structure of the device allows for untrained field use in the field. The internal structure of the detector comprising a replaceable sensitive element makes it possible to envisage low-cost and large-scale production of the sensitive element while retaining the same detector.

Claims

A device for detecting and / or quantifying traces of at least one organic compound present in a gas comprising:

a block (6) comprising an area (10) for recognizing and detecting said organic compound, and

a device (23) for transducing, in electrical information, the information transmitted by the zone (10),

characterized by further comprising:

a gas inlet (2),

a device (4) for pretreatment and purification of the gas entering through the inlet (2),

a module (22) for processing the electrical signal emitted by the information transducing device (23),

- a source of energy,

a system (19) for visual and audible warning,

and in that the device (23) is protected from electromagnetic waves.

2. Device according to claim 1 characterized in that it further comprises:

a module (3) for controlling the temperature of the gas entering through the inlet (2),

a device (5) for controlling the flow of gas entering the block (6),

a pump (7) for evacuation of the gas,

a vent (8) for evacuation of the gas,

and a hood (9) forming a Faraday cage, surrounding the entire device for detecting and / or quantifying traces of at least one organic compound and protecting the block (6) from electromagnetic waves.

3. Device according to claim 1 or 2 characterized in that it further comprises:

a memory card (20), and - a communication port (21) with a laptop or a USB key.

4. Device according to any one of the preceding claims, characterized in that the block (6) comprising the zone (10) for recognizing and detecting organic compounds and the transducing device (23) comprises:

at least one compound having a specific reaction with the organic compound to be detected, in zone (10),

an intermediate layer (14) made of a dielectric material,

a source electrode (11) placed on the intermediate layer (14), a drain electrode (12) placed on the intermediate layer (14),

a layer (13) made of a semiconductor material placed on and in contact with the intermediate layer (14) and between the source electrode (11) and the drain electrode (12) and in contact with these electrodes,

a gate electrode (15) placed under and in contact with the support (14), and

a device (16) for measuring the intensity of the current _{DS being} flowing between the drain electrode (12) and the source electrode (11), and

- A voltage generator (17) for applying a variable voltage V _GS between the gate electrode (15) and the source electrode (11).

5. Device according to claim 4 characterized in that the layer

(13) is doped or undoped silicon nanowires or nanoribbons, preferably etched on a "silicon on insulator" (SOI) surface.

6. Device according to any one of the preceding claims, characterized in that the organic compound to be detected is an organophosphorus compound of chemical formula (II) below:

(W) = PL ¹ L ² L ³

in which :

- W is O or S, and

at least one of the groups L ¹ L ² L ³ is a leaving group,

and in that the zone (10) is a monomolecular layer of organic receptor molecules comprising a receptor group of formula (I) below: (I)

Formula I

in which :

- n = 0, 1 or 2.

X is a group capable of reacting with the organophosphorus compound to be detected in order to form an intermediate group -Z, X being preferably chosen from the groups -CH ₂ OH, -CH NH ₂ , -CH ₂ SH;

7. Device according to claim 6, characterized in that the receptor group of formula (I) has the following formula:

- A-L-X

in which :

A is a group comprising a function Y as defined in claim 6,

X is as defined in claim 6, preferably X is -CH ₂ OH, and

A is a group comprising a tertiary amine, preferably a nitrogen-containing C ₃ to C ₆ hetero ring, more preferably a C ₃ to C ₆ heterocycloalkyl, preferably a C ₃ to C ₆ nitrogenous heteroaryl.

8. Device according to claim 6, characterized in that the receptor group of formula (I) has the following formula IV:

(IV)

Form IV

9. Device according to any one of claims 6 to 8 characterized in that the organic receptor molecules are grafted onto the layer (13) of a semiconductor material.

10. Device according to any one of claims 6 to 8 characterized in that the organic receptor molecules are grafted on at least one of the electrodes (11, 12).

11. A method for the detection and / or quantification of trace of at least one organic compound in a gas, characterized in that it comprises introducing the gas into the device according to any one of claims 1 to 10.

12. A method of detection and / or quantification according to claim 11 characterized in that the device in which the gas is introduced is a device according to any one of claims 4 to 10.

13. The method of claim 12 characterized in that it further comprises a step of recording the evolution of the current intensity (VGS (IOFF)) of the current flowing between the source electrode (11) and the drain electrode (12) as a function of the voltage V _G s applied between the source electrode (1 1) and the gate electrode (15).

14. The method of claim 12 characterized in that it comprises the following steps:

a) detecting and recording the variation of the electric current I _DS for a fixed voltage V _DS applied between the source electrode (11) and the drain electrode (12) as a function of the voltage V _G s during the introduction into the device for detecting and / or quantifying a gas that does not contain a compound to be detected,

b) determining the lowest current IOFF and the voltage VGS corresponding to the lowest current obtained in step a) and, c) applying the voltage V _GS (I _OFF ) between the gate electrode (15) and the source electrode (11) and detecting the variation of the current ½ in the presence of the gas suspected of containing the organic compound.

15. The method of claim 13 characterized in that the voltage VGS (I _OF F) applied to step c) is equal to 0 and in that the detection of the variation of the current IDS is resistant type.

16. The method of claim 12 characterized in that one detects and records the voltage variation V _GS , when the IDS current is kept constant during the passage of the gas suspected of containing the organic compound.