WO2012109243A3 - Method of treating intercellular barrier dysfunction - Google Patents

Method of treating intercellular barrier dysfunction Download PDF

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Publication number
WO2012109243A3
WO2012109243A3 PCT/US2012/024146 US2012024146W WO2012109243A3 WO 2012109243 A3 WO2012109243 A3 WO 2012109243A3 US 2012024146 W US2012024146 W US 2012024146W WO 2012109243 A3 WO2012109243 A3 WO 2012109243A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating
barrier dysfunction
intercellular barrier
intercellular
junctions
Prior art date
Application number
PCT/US2012/024146
Other languages
French (fr)
Other versions
WO2012109243A2 (en
Inventor
Yuping Wang
Original Assignee
Yuping Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuping Wang filed Critical Yuping Wang
Publication of WO2012109243A2 publication Critical patent/WO2012109243A2/en
Publication of WO2012109243A3 publication Critical patent/WO2012109243A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Abstract

A digoxin antibody composition is provided for preventing or attenuating disruption of tight junctions and adherens junctions, and resultant increase in paracellular permeability caused cardiotonic steroids.
PCT/US2012/024146 2011-02-07 2012-02-07 Method of treating intercellular barrier dysfunction WO2012109243A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161440001P 2011-02-07 2011-02-07
US61/440,001 2011-02-07

Publications (2)

Publication Number Publication Date
WO2012109243A2 WO2012109243A2 (en) 2012-08-16
WO2012109243A3 true WO2012109243A3 (en) 2012-11-01

Family

ID=46639158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/024146 WO2012109243A2 (en) 2011-02-07 2012-02-07 Method of treating intercellular barrier dysfunction

Country Status (1)

Country Link
WO (1) WO2012109243A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101507358B1 (en) * 2012-10-29 2015-04-08 대진대학교 산학협력단 Method for Reinforcing tight junction of Cell

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011028A1 (en) * 2002-07-25 2004-02-05 Charles David Adair Use of digoxin immune fab for the regulation of sodium/potassium atpase activity in preeclamptic and eclamptic patients
US20100297129A1 (en) * 2002-07-25 2010-11-25 Glenveigh Pharmaceutical, Llc Method for extending pregnancy in patients exhibiting at least one symptom of preeclampsia and eclampsia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011028A1 (en) * 2002-07-25 2004-02-05 Charles David Adair Use of digoxin immune fab for the regulation of sodium/potassium atpase activity in preeclamptic and eclamptic patients
US20100297129A1 (en) * 2002-07-25 2010-11-25 Glenveigh Pharmaceutical, Llc Method for extending pregnancy in patients exhibiting at least one symptom of preeclampsia and eclampsia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
WANG ET AL.: "Endothelial barrier function in preeclampsia.", FRONT BIOSCI, vol. 12, 1 January 2007 (2007-01-01), pages 2412 - 2424 *
WANG ET AL.: "Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia.", AM J OBSTET GYNECOL, vol. 186, no. 2, February 2002 (2002-02-01), pages 214 - 220 *

Also Published As

Publication number Publication date
WO2012109243A2 (en) 2012-08-16

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