WO2012106584A3 - Pitavastatin salts - Google Patents

Pitavastatin salts Download PDF

Info

Publication number
WO2012106584A3
WO2012106584A3 PCT/US2012/023745 US2012023745W WO2012106584A3 WO 2012106584 A3 WO2012106584 A3 WO 2012106584A3 US 2012023745 W US2012023745 W US 2012023745W WO 2012106584 A3 WO2012106584 A3 WO 2012106584A3
Authority
WO
WIPO (PCT)
Prior art keywords
pitavastatin
salts
pitavastatin salts
hydrates
isolation
Prior art date
Application number
PCT/US2012/023745
Other languages
French (fr)
Other versions
WO2012106584A2 (en
Inventor
Rama Rao Kvs
Srinivas Katkam
Rajeswar Reddy Sagyam
Jayaprakash Pitta
Sridhar Munagala
Vishweshwar Peddy
Arjun Kumar Tummala
Srinivasulu Ragineni
Hima Bindu DOOSA
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Publication of WO2012106584A2 publication Critical patent/WO2012106584A2/en
Publication of WO2012106584A3 publication Critical patent/WO2012106584A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure includes salt of pitavastatin, and processes for their preparation and isolation. It further relates to crystalline forms of pitavastatin salts and hydrates thereof, and process for preparing an amorphous form of pitavastatin
PCT/US2012/023745 2011-02-04 2012-02-03 Pitavastatin salts WO2012106584A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN326/CHE/2011 2011-02-04
IN326CH2011 2011-02-04
US201161466113P 2011-03-22 2011-03-22
US61/466,113 2011-03-22
IN3089/CHE/2011 2011-09-08
IN3089CH2011 2011-09-08
US201161549990P 2011-10-21 2011-10-21
US61/549,990 2011-10-21

Publications (2)

Publication Number Publication Date
WO2012106584A2 WO2012106584A2 (en) 2012-08-09
WO2012106584A3 true WO2012106584A3 (en) 2012-11-01

Family

ID=46603320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/023745 WO2012106584A2 (en) 2011-02-04 2012-02-03 Pitavastatin salts

Country Status (1)

Country Link
WO (1) WO2012106584A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ306425B6 (en) * 2012-05-16 2017-01-18 Zentiva, K.S. A method of preparing pitavastatin calcium salt
WO2014154856A1 (en) * 2013-03-29 2014-10-02 Dsm Sinochem Pharmaceuticals Netherlands B.V. Amine salts of pravastatin and rosuvastatin
MX2015013551A (en) * 2013-03-29 2016-02-05 Dsm Sinochem Pharm Nl Bv Pharmaceutically acceptable amine salts of pitavastatin.
MX2015013696A (en) * 2013-03-29 2016-02-26 Dsm Sinochem Pharm Nl Bv Amine salts of pitavastatin and rosuvastatin.
CN104860882A (en) * 2015-05-15 2015-08-26 苗怡文 Drug pitavastatin calcium composition for treating hyperlipidemia

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092571A1 (en) * 2000-09-01 2004-05-13 Sankyo Company, Limited Pharmaceutical composition
WO2004072040A1 (en) * 2003-02-12 2004-08-26 Ciba Specialty Chemicals Holding Inc. Crystalline forms of pitavastatin calcium
US20050209259A1 (en) * 2004-03-17 2005-09-22 Le Huang Novel anhydrous amorphous forms of rosuvastatin calcium, pitavastatin calcium and fluvastatin sodium
WO2007132482A2 (en) * 2006-05-17 2007-11-22 Manne Satyanarayana Reddy Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts
US20100197726A1 (en) * 2007-07-20 2010-08-05 Kowa Co., Ltd. Inhibitor of the differentiation of t cells into th1 cells
WO2010089770A2 (en) * 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092571A1 (en) * 2000-09-01 2004-05-13 Sankyo Company, Limited Pharmaceutical composition
WO2004072040A1 (en) * 2003-02-12 2004-08-26 Ciba Specialty Chemicals Holding Inc. Crystalline forms of pitavastatin calcium
US20050209259A1 (en) * 2004-03-17 2005-09-22 Le Huang Novel anhydrous amorphous forms of rosuvastatin calcium, pitavastatin calcium and fluvastatin sodium
WO2007132482A2 (en) * 2006-05-17 2007-11-22 Manne Satyanarayana Reddy Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts
US20100197726A1 (en) * 2007-07-20 2010-08-05 Kowa Co., Ltd. Inhibitor of the differentiation of t cells into th1 cells
WO2010089770A2 (en) * 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
WO2012106584A2 (en) 2012-08-09

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