WO2012103464A3 - Oral thin film vaccine preparation - Google Patents
Oral thin film vaccine preparation Download PDFInfo
- Publication number
- WO2012103464A3 WO2012103464A3 PCT/US2012/022952 US2012022952W WO2012103464A3 WO 2012103464 A3 WO2012103464 A3 WO 2012103464A3 US 2012022952 W US2012022952 W US 2012022952W WO 2012103464 A3 WO2012103464 A3 WO 2012103464A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thin film
- vaccine preparation
- vaccine
- rotovirus
- oral thin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Disclosed herein are methods for thermostable Rotovirus vaccine preparations for oral administration. The preparation of the present invention provides an effective Rotovirus vaccine preparation that has a shelf-life. The thermostable Rotovirus vaccine is prepared on an oral thin film which can be packaged and delivered to remote areas where sources of electricity and refrigeration are cost prohibitive.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161437463P | 2011-01-28 | 2011-01-28 | |
US61/437,463 | 2011-01-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012103464A2 WO2012103464A2 (en) | 2012-08-02 |
WO2012103464A3 true WO2012103464A3 (en) | 2012-09-20 |
Family
ID=46581186
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/022962 WO2012103472A1 (en) | 2011-01-28 | 2012-01-27 | Granularized particular thermostable rotovirus vaccine preparation |
PCT/US2012/022952 WO2012103464A2 (en) | 2011-01-28 | 2012-01-27 | Oral thin film vaccine preparation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/022962 WO2012103472A1 (en) | 2011-01-28 | 2012-01-27 | Granularized particular thermostable rotovirus vaccine preparation |
Country Status (1)
Country | Link |
---|---|
WO (2) | WO2012103472A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2856187T3 (en) | 2013-05-31 | 2021-09-27 | Victor Bronshtein | Polymeric compositions containing biopharmaceuticals stable at room temperature and methods for their formulation |
US9044390B1 (en) | 2014-04-17 | 2015-06-02 | Gary J. Speier | Pharmaceutical composition and method of manufacturing |
US9186386B2 (en) | 2014-04-17 | 2015-11-17 | Gary J. Speier | Pharmaceutical composition and method of manufacturing |
WO2017214187A1 (en) * | 2016-06-07 | 2017-12-14 | Aridis Pharmaceuticals, Inc. | Method for preparation of quick dissolving thin films containing bioactive material with enhanced thermal stability |
GB201614799D0 (en) * | 2016-09-01 | 2016-10-19 | Glaxosmithkline Biologicals Sa | Compositions |
EP3941436B1 (en) * | 2019-03-19 | 2023-12-13 | GlaxoSmithKline Biologicals SA | Thermostable quick-disolving thin film |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020076440A1 (en) * | 1999-06-25 | 2002-06-20 | Thomas Leon | Veterinary delivery systems and methods of delivering effective agents to animals |
US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
US20040036193A1 (en) * | 2002-08-23 | 2004-02-26 | Berry Craig J. | Process for manufacturing thin film strips |
US20080166372A1 (en) * | 2005-02-17 | 2008-07-10 | Glaxosmithkline Biologicals S.A., | Live Attenuated Rotavirus Vaccine for Oral Administration |
WO2010002418A2 (en) * | 2008-07-01 | 2010-01-07 | The Johns Hopkins University | Quick-dissolving oral thin film for targeted delivery of therapeutic agents |
US20100209455A1 (en) * | 2007-09-04 | 2010-08-19 | Baoming Jiang | Thermal inactivation of rotavirus |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6616931B1 (en) * | 1996-09-26 | 2003-09-09 | Merck & Co., Inc. | Rotavirus vaccine formulations |
GB0020089D0 (en) * | 2000-08-15 | 2000-10-04 | Smithkline Beecham Biolog | Vaccine Composition |
US20060165674A1 (en) * | 2002-11-22 | 2006-07-27 | Toshikazu Koyama | Granular composition and process for producing the same |
GB0414787D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxosmithkline Biolog Sa | Method |
WO2008014175A2 (en) * | 2006-07-28 | 2008-01-31 | Dr. Reddy's Laboratories Ltd. | Granular pharmaceutical compositions |
WO2009131995A1 (en) * | 2008-04-21 | 2009-10-29 | Nanobio Corporation | Nanoemulsion influenza vaccine |
-
2012
- 2012-01-27 WO PCT/US2012/022962 patent/WO2012103472A1/en active Application Filing
- 2012-01-27 WO PCT/US2012/022952 patent/WO2012103464A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020076440A1 (en) * | 1999-06-25 | 2002-06-20 | Thomas Leon | Veterinary delivery systems and methods of delivering effective agents to animals |
US20030092145A1 (en) * | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
US20040036193A1 (en) * | 2002-08-23 | 2004-02-26 | Berry Craig J. | Process for manufacturing thin film strips |
US20080166372A1 (en) * | 2005-02-17 | 2008-07-10 | Glaxosmithkline Biologicals S.A., | Live Attenuated Rotavirus Vaccine for Oral Administration |
US20100209455A1 (en) * | 2007-09-04 | 2010-08-19 | Baoming Jiang | Thermal inactivation of rotavirus |
WO2010002418A2 (en) * | 2008-07-01 | 2010-01-07 | The Johns Hopkins University | Quick-dissolving oral thin film for targeted delivery of therapeutic agents |
Also Published As
Publication number | Publication date |
---|---|
WO2012103472A1 (en) | 2012-08-02 |
WO2012103464A2 (en) | 2012-08-02 |
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