WO2012099482A8 - Device, method and system for preparing microcapsules - Google Patents

Device, method and system for preparing microcapsules Download PDF

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Publication number
WO2012099482A8
WO2012099482A8 PCT/PT2012/000003 PT2012000003W WO2012099482A8 WO 2012099482 A8 WO2012099482 A8 WO 2012099482A8 PT 2012000003 W PT2012000003 W PT 2012000003W WO 2012099482 A8 WO2012099482 A8 WO 2012099482A8
Authority
WO
WIPO (PCT)
Prior art keywords
microcapsules
micro
formation
cell mixture
oil
Prior art date
Application number
PCT/PT2012/000003
Other languages
French (fr)
Other versions
WO2012099482A2 (en
WO2012099482A3 (en
Inventor
Erkan Türker BARAN
Ana Carina Loureiro MENDES
Helena Paula de Sousa Sepúlveda AZEVEDO
Rui Luis Gonçalves dos REIS
Original Assignee
Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) filed Critical Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec)
Publication of WO2012099482A2 publication Critical patent/WO2012099482A2/en
Publication of WO2012099482A8 publication Critical patent/WO2012099482A8/en
Publication of WO2012099482A3 publication Critical patent/WO2012099482A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0052—Preparation of gels
    • B01J13/0065—Preparation of gels containing an organic phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention discloses a novel device for the formation of microcapsules based on micro-droplet generation inside silicone tubing, which is punctured with a blunt-ended syringe needle vertically (1). The device uses droplet generation by vertical injection of hydrophilic polymer/cell mixture into hydrophobic oil flow, which is horizontally maintained in the silicone tubing. The injection of polymer/cell mixture into a stream of mineral oil results in the generation of spherical droplet and in the formation of a water- in-oil emulsion due to the immiscibility of the two phases. Subsequently, the micro-droplets in oil phase are converted into stable microcapsules by gelation in a separate chamber which is loaded with ionic cross- linking solution at physiological ionic strength and pH. The utility of the microcapsules generated by the device of present invention is virtually unlimited in the fields of regenerative medicine, controlled delivery of growth factor or drug.
PCT/PT2012/000003 2011-01-18 2012-01-17 Device, method and system for preparing microcapsules WO2012099482A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT105489 2011-01-18
PT10548911A PT105489B (en) 2011-01-18 2011-01-18 DEVICE, METHOD AND SYSTEM OF MANUFACTURE OF MICROCAPSULES

Publications (3)

Publication Number Publication Date
WO2012099482A2 WO2012099482A2 (en) 2012-07-26
WO2012099482A8 true WO2012099482A8 (en) 2012-09-13
WO2012099482A3 WO2012099482A3 (en) 2012-11-01

Family

ID=45771869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2012/000003 WO2012099482A2 (en) 2011-01-18 2012-01-17 Device, method and system for preparing microcapsules

Country Status (2)

Country Link
PT (1) PT105489B (en)
WO (1) WO2012099482A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016018678A1 (en) * 2014-07-30 2016-02-04 The Regents Of The University Of California Methods for bacteriophage detection
CN108354181A (en) * 2018-03-23 2018-08-03 刘洪明 A kind of preparation method and system of three probiotic microcapsules
CN109499492B (en) * 2018-11-30 2023-10-31 南昌大学 Preparation device and preparation method of allantoin-coated snake oil gel
WO2022179983A1 (en) * 2021-02-26 2022-09-01 Microcaps Ag Capsules with a hydrogel matrix
CN114921343B (en) * 2022-06-28 2023-09-05 中国科学院苏州生物医学工程技术研究所 Cell gel microsphere generating device based on high-voltage pulse electric field

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9814619D0 (en) * 1998-07-06 1998-09-02 Cole Polytechnique Fudurale De Materials and methods relating to encapsulation
WO2001009342A1 (en) * 1999-07-30 2001-02-08 University College London Microencapsulated nitric oxide synthase source
CN101695646A (en) * 2009-10-28 2010-04-21 中国海洋大学 Device and method for preparing gel microspheres with uniform grain sizes

Also Published As

Publication number Publication date
PT105489A (en) 2012-07-18
WO2012099482A2 (en) 2012-07-26
WO2012099482A3 (en) 2012-11-01
PT105489B (en) 2014-05-13

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