WO2012078066A3 - Processo para deposição de biomateriais em substratos repelentes a água e resultantes biomateriais - Google Patents

Processo para deposição de biomateriais em substratos repelentes a água e resultantes biomateriais Download PDF

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Publication number
WO2012078066A3
WO2012078066A3 PCT/PT2011/000043 PT2011000043W WO2012078066A3 WO 2012078066 A3 WO2012078066 A3 WO 2012078066A3 PT 2011000043 W PT2011000043 W PT 2011000043W WO 2012078066 A3 WO2012078066 A3 WO 2012078066A3
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WO
WIPO (PCT)
Prior art keywords
biomaterials
substrates
deposition
present
relates
Prior art date
Application number
PCT/PT2011/000043
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English (en)
French (fr)
Other versions
WO2012078066A2 (pt
Inventor
Ana Isabel Morais Neto
Mariana Braga De Oliveira
Catarina DE ALMEIDA CUSTÓDIO
Wenlong Song
João Filipe Colardelle DA LUZ MANO
Original Assignee
Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) - Associação
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Application filed by Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) - Associação filed Critical Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) - Associação
Publication of WO2012078066A2 publication Critical patent/WO2012078066A2/pt
Publication of WO2012078066A3 publication Critical patent/WO2012078066A3/pt

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00635—Introduction of reactive groups to the surface by reactive plasma treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment

Abstract

A presente invenção diz respeito a um processo para a deposição de biomateriais em superfícies envolvendo a configuração de áreas com diferentes tensões superficiais à superfície de substratos com elevada repelência a água, através de tratamento que aumente a molhabilidade, como por exemplo, irradiação ultravioleta e ozono ou plasma. Um outro aspecto da presente invenção diz respeito aos substratos compreendendo áreas com diferenças de tensão superficial, que apresentam características específicas e controláveis de molhabilidade, úteis para efectuar a deposição controlada de soluções de biomateriais, confinados nas regiões molháveis permitindo a sua manipulação e análise individualizadas. Um terceiro aspecto da presente invenção diz respeito a produtos ou artigos compreendendo biomateriais depositados nos referidos substratos.
PCT/PT2011/000043 2010-12-07 2011-12-07 Processo para deposição de biomateriais em substratos repelentes a água e resultantes biomateriais WO2012078066A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT105960 2010-12-07
PT10596010A PT105960A (pt) 2010-12-07 2010-12-07 Processo para deposição de biomateriais em substratos repelentes a água e resultantes biomateriais

Publications (2)

Publication Number Publication Date
WO2012078066A2 WO2012078066A2 (pt) 2012-06-14
WO2012078066A3 true WO2012078066A3 (pt) 2012-08-16

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PCT/PT2011/000043 WO2012078066A2 (pt) 2010-12-07 2011-12-07 Processo para deposição de biomateriais em substratos repelentes a água e resultantes biomateriais

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PT (1) PT105960A (pt)
WO (1) WO2012078066A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2684601B1 (en) * 2012-07-13 2019-11-20 Karlsruher Institut für Technologie Formation of droplet or hydrogel arrays using hydrophilic-hydrophobic patterned surfaces for high-throughput screening applications
MX2019004996A (es) 2016-11-18 2019-09-27 Kimberly Clark Co Metodo de patrones de humectabilidad y diseños para transporte sin bombeo y manipulacion precisa de volumenes de liquidos en y a traves de materiales porosos.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053617A1 (en) * 1999-03-08 2000-09-14 Protogene Laboratories, Inc. Methods and compositions for economically synthesizing and assembling long dna sequences
EP1364702A2 (en) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Process for producing array plate for biomolecules having hydrophilic and hydrophobic regions
US20090264316A1 (en) * 2008-04-17 2009-10-22 Marshall University Research Corporation Ultraviolet/Ozone Patterned Organosilane Surfaces

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US20020142304A1 (en) 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053617A1 (en) * 1999-03-08 2000-09-14 Protogene Laboratories, Inc. Methods and compositions for economically synthesizing and assembling long dna sequences
EP1364702A2 (en) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Process for producing array plate for biomolecules having hydrophilic and hydrophobic regions
US20090264316A1 (en) * 2008-04-17 2009-10-22 Marshall University Research Corporation Ultraviolet/Ozone Patterned Organosilane Surfaces

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANA I. NETO ET AL: "High-throughput evaluation of interactions between biomaterials, proteins and cells using patterned superhydrophobic substrates", SOFT MATTER, vol. 7, no. 9, 25 March 2011 (2011-03-25), pages 4147, XP055024092, ISSN: 1744-683X, DOI: 10.1039/c1sm05169e *
LUZ G M ET AL: "Wettable arrays onto superhydrophobic surfaces for bioactivity testing of inorganic nanoparticles", MATERIALS LETTERS, NORTH HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 65, no. 2, 29 September 2010 (2010-09-29), pages 296 - 299, XP027542226, ISSN: 0167-577X, [retrieved on 20100929] *
NUNO M. OLIVEIRA ET AL: "Two-Dimensional Open Microfluidic Devices by Tuning the Wettability on Patterned Superhydrophobic Polymeric Surface", APPLIED PHYSICS EXPRESS, vol. 3, no. 8, 1 August 2010 (2010-08-01), pages 085205, XP055024106, ISSN: 1882-0778, DOI: 10.1143/APEX.3.085205 *
WENLONG SONG ET AL: "Bioinspired Degradable Substrates with Extreme Wettability Properties", ADVANCED MATERIALS, vol. 21, no. 18, 11 May 2009 (2009-05-11), pages 1830 - 1834, XP055024136, ISSN: 0935-9648, DOI: 10.1002/adma.200803680 *

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PT105960A (pt) 2012-08-16
WO2012078066A2 (pt) 2012-06-14

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