WO2012075114A3 - Nucleic acid-polymer conjugates and uses thereof - Google Patents

Nucleic acid-polymer conjugates and uses thereof Download PDF

Info

Publication number
WO2012075114A3
WO2012075114A3 PCT/US2011/062588 US2011062588W WO2012075114A3 WO 2012075114 A3 WO2012075114 A3 WO 2012075114A3 US 2011062588 W US2011062588 W US 2011062588W WO 2012075114 A3 WO2012075114 A3 WO 2012075114A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
polymer conjugates
polymer
conjugates
disease
Prior art date
Application number
PCT/US2011/062588
Other languages
French (fr)
Other versions
WO2012075114A2 (en
Inventor
Nicholas Lee Hammond
Tyler Weis Hodges
Lisa Kay Kemp
Original Assignee
Ablitech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablitech, Inc. filed Critical Ablitech, Inc.
Publication of WO2012075114A2 publication Critical patent/WO2012075114A2/en
Publication of WO2012075114A3 publication Critical patent/WO2012075114A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described herein are nucleic acid-polymer conjugates comprising a nucleic acid linked to a polymer described herein. Also described herein is the use of such nucleic acid-polymer conjugates for the treatment of disease.
PCT/US2011/062588 2010-12-01 2011-11-30 Nucleic acid-polymer conjugates and uses thereof WO2012075114A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41866310P 2010-12-01 2010-12-01
US61/418,663 2010-12-01

Publications (2)

Publication Number Publication Date
WO2012075114A2 WO2012075114A2 (en) 2012-06-07
WO2012075114A3 true WO2012075114A3 (en) 2014-04-10

Family

ID=46172528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/062588 WO2012075114A2 (en) 2010-12-01 2011-11-30 Nucleic acid-polymer conjugates and uses thereof

Country Status (1)

Country Link
WO (1) WO2012075114A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160305A1 (en) * 2013-03-14 2014-10-02 Albany Molecular Research, Inc. Ligand-therapeutic agent conjugates and silicon-based linkers
AU2014274730A1 (en) * 2013-06-07 2016-01-21 Rana Therapeutics, Inc. Compositions and methods for modulating FOXP3 expression
EP3166615B1 (en) * 2014-07-10 2023-08-09 Replicor Inc. Chelated phosphorotiotated nucleic acid polymers for use in combination with a hbv polymerase inhibitor for the treatment of hepatitis b and hepatitis d virus infections

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017196A1 (en) * 1998-07-02 2003-01-23 Stein Cy A. Oligonucleotide inhibitors of bcl-xL
US20040127694A1 (en) * 2000-09-28 2004-07-01 Komeluk Robert G. Antisense IAP oligonucleotides and uses thereof
US20050176667A1 (en) * 2001-01-09 2005-08-11 Alnylam Europe Ag Compositions and methods for inhibiting expression of anti-apoptotic genes
US20080058322A1 (en) * 2001-11-01 2008-03-06 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
WO2008043561A2 (en) * 2006-10-11 2008-04-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Influenza targets
US20090163702A1 (en) * 2002-11-14 2009-06-25 Dharmacon Inc. siRNA targeting Myeloid cell leukemia sequence 1
US20090186802A1 (en) * 2005-12-16 2009-07-23 Diatos Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017196A1 (en) * 1998-07-02 2003-01-23 Stein Cy A. Oligonucleotide inhibitors of bcl-xL
US20040127694A1 (en) * 2000-09-28 2004-07-01 Komeluk Robert G. Antisense IAP oligonucleotides and uses thereof
US20050176667A1 (en) * 2001-01-09 2005-08-11 Alnylam Europe Ag Compositions and methods for inhibiting expression of anti-apoptotic genes
US20080058322A1 (en) * 2001-11-01 2008-03-06 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
US20090163702A1 (en) * 2002-11-14 2009-06-25 Dharmacon Inc. siRNA targeting Myeloid cell leukemia sequence 1
US20090186802A1 (en) * 2005-12-16 2009-07-23 Diatos Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell
WO2008043561A2 (en) * 2006-10-11 2008-04-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Influenza targets

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOGOI ET AL.: "A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.", NUCLEIC ACIDS RES., vol. 35, no. 21, 2007, pages E139 *
RAJAGOPAL ET AL.: "Functions of the type 1 BMP receptor Acvr1 (AIk2) in lens development: cell proliferation, terminal differentiation, and survival.", INVEST. OPHTHAMOL. VIS. SCI., vol. 49, no. 11, 2008, pages 4953 - 4960 *
ROZEMA ET AL.: "Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.", PROC. NATL. ACAD. SCI. USA, vol. 104, no. 32, 2007, pages 12982 - 12987 *
XUE ET AL.: "Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats.", GENE THER., vol. 17, no. 3, 2009, pages 370 - 379 *

Also Published As

Publication number Publication date
WO2012075114A2 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
IL244858A (en) Molecular conjugates of fumarate and a fatty acid, pharmaceutical compositions comprising the same and uses thereof
EP2585595B8 (en) Rna molecules and uses thereof
EP2558493A4 (en) Antibodies for the treatment of clostridium difficile-associated infection and disease
IL217828B (en) Crystalline molecular complex of zoledronic acid, lysine, and water, pharmaceutical compositions comprising the same and uses thereof
WO2012087826A3 (en) Urological medical devices
EP2631291A4 (en) Nucleic acid molecules inducing rna interference, and uses thereof
WO2012129341A3 (en) Disease detection in plants
MX347734B (en) S100a4 antibodies and therapeutic uses thereof.
WO2011038933A3 (en) Anti-hsv antibody
WO2011138040A3 (en) Vaccine against beta-herpesvirus infection and use thereof
IL278149A (en) Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
WO2011107866A3 (en) Silyl-derivatives of polysaccharides
WO2012075114A3 (en) Nucleic acid-polymer conjugates and uses thereof
WO2011136513A3 (en) Bone-transplant or bone-filling composition comprising a dihydroxybenzoic acid derivative
WO2013071400A8 (en) Apocynin-lipoic acid conjugates and uses thereof cross-reference to related applications
EP2751137A4 (en) Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
WO2011000945A3 (en) Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns
WO2011127482A3 (en) Modulation of histone deacetylases for the treatment of metabolic disease, methods and compositions related thereto
WO2012094495A3 (en) Clip modulation for the treatment of mucosal diseases
FR2957347B1 (en) HYDROXYL AND HYDROGEN OLIGOMERS FROM CONJUGATED LINOLEIC ACID, AND THEIR APPLICATIONS
WO2011150082A9 (en) Methods of utilizing the arrestin-2/stam-1 complex as a therapeutic target
WO2013109202A3 (en) Pharmaceutical compounds comprising cefetamet
IT1406405B1 (en) PEPTIDIC MOLECULES FOR THE TREATMENT OF MITOCONDRIAL DISEASES
TH118513B (en) Multimedia player
TH110538B (en) toy

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11844141

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 11844141

Country of ref document: EP

Kind code of ref document: A2