WO2012070798A3 - Topical antifungal composition comprising terbinafine or its salt - Google Patents

Topical antifungal composition comprising terbinafine or its salt Download PDF

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Publication number
WO2012070798A3
WO2012070798A3 PCT/KR2011/008684 KR2011008684W WO2012070798A3 WO 2012070798 A3 WO2012070798 A3 WO 2012070798A3 KR 2011008684 W KR2011008684 W KR 2011008684W WO 2012070798 A3 WO2012070798 A3 WO 2012070798A3
Authority
WO
WIPO (PCT)
Prior art keywords
terbinafine
salt
topical antifungal
antifungal composition
skin
Prior art date
Application number
PCT/KR2011/008684
Other languages
French (fr)
Other versions
WO2012070798A2 (en
Inventor
Min-Ah Sung
Dong-Hun Lee
Mi-Young Kim
Yoong-Sik Park
Original Assignee
Yuhan Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corporation filed Critical Yuhan Corporation
Publication of WO2012070798A2 publication Critical patent/WO2012070798A2/en
Publication of WO2012070798A3 publication Critical patent/WO2012070798A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a topical antifungal having excellent properties in skin penetration and retention in the skin. Specifically, the present invention provides a topical antifungal composition comprising terbinafine or its salt; a film-forming agent; a solvent; and one or more selected from the group consisting of urea, 1-dodecylurea, and 1,3-didodecylurea as an agent for increasing retention of terbinafine or its salt in an applied skin.
PCT/KR2011/008684 2010-11-24 2011-11-15 Topical antifungal composition comprising terbinafine or its salt WO2012070798A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100117268A KR20120056314A (en) 2010-11-24 2010-11-24 Topical antifungal composition comprising terbinafine or its salt
KR10-2010-0117268 2010-11-24

Publications (2)

Publication Number Publication Date
WO2012070798A2 WO2012070798A2 (en) 2012-05-31
WO2012070798A3 true WO2012070798A3 (en) 2012-08-09

Family

ID=46146250

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/008684 WO2012070798A2 (en) 2010-11-24 2011-11-15 Topical antifungal composition comprising terbinafine or its salt

Country Status (2)

Country Link
KR (1) KR20120056314A (en)
WO (1) WO2012070798A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2706115C1 (en) * 2018-11-19 2019-11-14 Николай Андреевич Комиссаренко Antifungal and antimicrobial agent of complex action
DE102020211387A1 (en) * 2020-09-10 2022-03-10 Beiersdorf Aktiengesellschaft Wound closure preparation containing active ingredients

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042845A (en) * 1994-12-22 2000-03-28 Johnson & Johnson Consumer Products, Inc. Anti fungal treatment of nails
KR20000045198A (en) * 1998-12-30 2000-07-15 김수지 Antifungal nail varnish
KR20070024543A (en) * 2004-04-27 2007-03-02 마르셀 님니 Antifungal drug delivery
KR100979347B1 (en) * 2009-03-25 2010-08-31 삼일제약주식회사 Antifungal composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042845A (en) * 1994-12-22 2000-03-28 Johnson & Johnson Consumer Products, Inc. Anti fungal treatment of nails
KR20000045198A (en) * 1998-12-30 2000-07-15 김수지 Antifungal nail varnish
KR20070024543A (en) * 2004-04-27 2007-03-02 마르셀 님니 Antifungal drug delivery
KR100979347B1 (en) * 2009-03-25 2010-08-31 삼일제약주식회사 Antifungal composition

Also Published As

Publication number Publication date
KR20120056314A (en) 2012-06-04
WO2012070798A2 (en) 2012-05-31

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