WO2012068531A3 - Novel compositions and uses of anti-hypertension agents for cancer therapy - Google Patents

Novel compositions and uses of anti-hypertension agents for cancer therapy Download PDF

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Publication number
WO2012068531A3
WO2012068531A3 PCT/US2011/061510 US2011061510W WO2012068531A3 WO 2012068531 A3 WO2012068531 A3 WO 2012068531A3 US 2011061510 W US2011061510 W US 2011061510W WO 2012068531 A3 WO2012068531 A3 WO 2012068531A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer therapy
novel compositions
cancer
compositions
hypertension agents
Prior art date
Application number
PCT/US2011/061510
Other languages
French (fr)
Other versions
WO2012068531A2 (en
Inventor
Rakesh Kumar Jain
Yves Boucher
Vikash Pal Singh Chauhan
Benjamin Diop-Frimpong
Stephen Krane
Alan L. Crane
Robert Samuel Langer
Original Assignee
The General Hospital Corporation
Xtuit Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation, Xtuit Pharmaceuticals, Inc. filed Critical The General Hospital Corporation
Priority to RU2013127625/15A priority Critical patent/RU2013127625A/en
Priority to CN201180065389.2A priority patent/CN103561726A/en
Priority to CA2817250A priority patent/CA2817250A1/en
Priority to EP11841427.5A priority patent/EP2640359A4/en
Priority to AU2011329638A priority patent/AU2011329638C1/en
Priority to JP2013540082A priority patent/JP2014505666A/en
Publication of WO2012068531A2 publication Critical patent/WO2012068531A2/en
Priority to US13/834,094 priority patent/US20130287688A1/en
Publication of WO2012068531A3 publication Critical patent/WO2012068531A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods and compositions for improving the delivery and/or efficacy of cancer therapeutics are disclosed. Methods and compositions for treating or preventing a cancer (e.g., a solid tumor such as a desmoplastic tumor) by administering to a subject an antihypertensive agent, as a single agent or combination with a cancer therapeutic agent (for example, a therapeutic agent ranging in size from a large nanotherapeutic to a low molecular weight chemotherapeutics and/or oxygen radical) are disclosed.
PCT/US2011/061510 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy WO2012068531A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU2013127625/15A RU2013127625A (en) 2010-11-18 2011-11-18 NEW COMPOSITIONS AND APPLICATIONS OF ANTIHYPERTENSIVE MEDICINES FOR CANCER THERAPY
CN201180065389.2A CN103561726A (en) 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy
CA2817250A CA2817250A1 (en) 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy
EP11841427.5A EP2640359A4 (en) 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy
AU2011329638A AU2011329638C1 (en) 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy
JP2013540082A JP2014505666A (en) 2010-11-18 2011-11-18 Antihypertensive composition and use for cancer treatment
US13/834,094 US20130287688A1 (en) 2010-11-18 2013-03-15 Novel compositions and uses of anti-hypertension agents for cancer therapy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41519210P 2010-11-18 2010-11-18
US61/415,192 2010-11-18
US201161438240P 2011-01-31 2011-01-31
US61/438,240 2011-01-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/834,094 Continuation-In-Part US20130287688A1 (en) 2010-11-18 2013-03-15 Novel compositions and uses of anti-hypertension agents for cancer therapy

Publications (2)

Publication Number Publication Date
WO2012068531A2 WO2012068531A2 (en) 2012-05-24
WO2012068531A3 true WO2012068531A3 (en) 2013-11-28

Family

ID=46084685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/061510 WO2012068531A2 (en) 2010-11-18 2011-11-18 Novel compositions and uses of anti-hypertension agents for cancer therapy

Country Status (7)

Country Link
EP (1) EP2640359A4 (en)
JP (2) JP2014505666A (en)
CN (1) CN103561726A (en)
AU (1) AU2011329638C1 (en)
CA (1) CA2817250A1 (en)
RU (2) RU2018102375A (en)
WO (1) WO2012068531A2 (en)

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CN102245642A (en) 2008-10-15 2011-11-16 安吉奥开米公司 Conjugates of GLP-1 agonists and uses thereof
RU2531591C2 (en) 2008-10-15 2014-10-20 Ангиокем Инк. Etoposide and doxorubicin conjugates for drug delivery
AU2009322043A1 (en) 2008-12-05 2011-07-07 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
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EA201590822A1 (en) * 2012-11-02 2016-01-29 Фармасайкликс, Инк. ADJUVANT THERAPY INHIBITOR KINASE OF THE FAMILY TEC
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EP3062790B1 (en) * 2013-11-01 2023-03-08 Pitney Pharmaceuticals Pty Limited Pharmaceutical combinations for the treatment of cancer
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CA2983755A1 (en) * 2015-04-25 2016-11-03 The General Hospital Corporation Anti-fugetactic agent and immunotherapy agent combination therapy and compositions for the treatment of cancer
DK3307326T3 (en) 2015-06-15 2020-10-19 Angiochem Inc METHODS FOR THE TREATMENT OF LEPTOMENINGAL CARCINOMATOSIS
CN105326812A (en) * 2015-10-28 2016-02-17 南昌大学 Sorafenib solid lipid nanoparticles and preparation method thereof
WO2017106630A1 (en) 2015-12-18 2017-06-22 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
JP6956091B2 (en) * 2016-08-26 2021-10-27 哲治 奥野 Micronanologic agents and their use
CA3038657A1 (en) * 2016-09-27 2018-04-05 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors
CN108358995B (en) * 2017-01-25 2021-07-06 四川大学 CP-iRGD polypeptide, iDPP nanoparticle, drug-loaded compound and preparation method and application thereof
RU2724398C1 (en) * 2019-09-03 2020-06-23 Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for determining aggressiveness of lung cancer
US20230101687A1 (en) * 2019-12-13 2023-03-30 Massachusetts Institute Of Technology Synthetic tissue barriers and uses thereof
EP3842099A1 (en) 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Use of losartan for the treatment of fibrotic diseases, in particular epidermolysis bullosa
CN114917345A (en) * 2021-04-07 2022-08-19 北京蛋白质组研究中心 Application of compound targeting SOAT1 protein in preparation of medicine for preventing and/or treating liver cancer
CN115317627B (en) * 2022-08-26 2023-10-24 江西中医药大学 Application of ABT-510 peptide in preparation of tumor imaging agent

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Also Published As

Publication number Publication date
CA2817250A1 (en) 2012-05-24
EP2640359A2 (en) 2013-09-25
JP2017101056A (en) 2017-06-08
AU2011329638B2 (en) 2016-10-13
JP2014505666A (en) 2014-03-06
WO2012068531A2 (en) 2012-05-24
CN103561726A (en) 2014-02-05
EP2640359A4 (en) 2015-11-04
AU2011329638A1 (en) 2013-05-30
RU2018102375A (en) 2019-02-21
RU2013127625A (en) 2014-12-27
AU2011329638C1 (en) 2017-04-27

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