WO2012064845A3 - G-csf polymer conjugates having a releasable linkage - Google Patents

G-csf polymer conjugates having a releasable linkage Download PDF

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Publication number
WO2012064845A3
WO2012064845A3 PCT/US2011/059976 US2011059976W WO2012064845A3 WO 2012064845 A3 WO2012064845 A3 WO 2012064845A3 US 2011059976 W US2011059976 W US 2011059976W WO 2012064845 A3 WO2012064845 A3 WO 2012064845A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer conjugates
releasable linkage
csf
conjugates
csf polymer
Prior art date
Application number
PCT/US2011/059976
Other languages
French (fr)
Other versions
WO2012064845A2 (en
Inventor
Mary J. Bossard
Ping Zhang
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of WO2012064845A2 publication Critical patent/WO2012064845A2/en
Publication of WO2012064845A3 publication Critical patent/WO2012064845A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides G-CSF-polymer conjugates having a releasable linkage. Methods of making conjugates and methods for administering conjugates are also provided.
PCT/US2011/059976 2010-11-09 2011-11-09 G-csf polymer conjugates having a releasable linkage WO2012064845A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41182610P 2010-11-09 2010-11-09
US61/411,826 2010-11-09
US201161530812P 2011-09-02 2011-09-02
US61/530,812 2011-09-02

Publications (2)

Publication Number Publication Date
WO2012064845A2 WO2012064845A2 (en) 2012-05-18
WO2012064845A3 true WO2012064845A3 (en) 2012-07-05

Family

ID=46051536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/059976 WO2012064845A2 (en) 2010-11-09 2011-11-09 G-csf polymer conjugates having a releasable linkage

Country Status (1)

Country Link
WO (1) WO2012064845A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109096483B (en) * 2017-06-28 2020-09-04 北京键凯科技股份有限公司 Branched polyglyol epoxy derivative cross-linked sodium hyaluronate gel and preparation and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060293499A1 (en) * 2005-06-16 2006-12-28 Bentley Michael D Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US20070009478A1 (en) * 2005-06-01 2007-01-11 Maxygen Holdings Ltd. Pegylated g-csf polypeptides and methods of producing same
US20070092482A1 (en) * 2005-08-04 2007-04-26 Bossard Mary J Conjugates of a G-CSF moiety and a polymer
US20070166278A1 (en) * 2004-04-15 2007-07-19 Veronese Francesco M Novel g-csf conjugates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166278A1 (en) * 2004-04-15 2007-07-19 Veronese Francesco M Novel g-csf conjugates
US20070009478A1 (en) * 2005-06-01 2007-01-11 Maxygen Holdings Ltd. Pegylated g-csf polypeptides and methods of producing same
US20060293499A1 (en) * 2005-06-16 2006-12-28 Bentley Michael D Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US20070092482A1 (en) * 2005-08-04 2007-04-26 Bossard Mary J Conjugates of a G-CSF moiety and a polymer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PASUT ET AL.: "A new PEG-beta-alanine active derivative for releasable protein conjugation.", BIOCONJUG CHEM., vol. 19, no. 12, 2008, pages 2427 - 31 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109096483B (en) * 2017-06-28 2020-09-04 北京键凯科技股份有限公司 Branched polyglyol epoxy derivative cross-linked sodium hyaluronate gel and preparation and application thereof

Also Published As

Publication number Publication date
WO2012064845A2 (en) 2012-05-18

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