WO2012061651A1 - Articles incorporating absorbert polymer and ceragenin compound - Google Patents
Articles incorporating absorbert polymer and ceragenin compound Download PDFInfo
- Publication number
- WO2012061651A1 WO2012061651A1 PCT/US2011/059228 US2011059228W WO2012061651A1 WO 2012061651 A1 WO2012061651 A1 WO 2012061651A1 US 2011059228 W US2011059228 W US 2011059228W WO 2012061651 A1 WO2012061651 A1 WO 2012061651A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- absorbent
- csa
- ceragenin
- absorbent article
- polymer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 97
- 229920000642 polymer Polymers 0.000 title claims abstract description 75
- 239000002250 absorbent Substances 0.000 claims abstract description 146
- 230000002745 absorbent Effects 0.000 claims abstract description 145
- 125000002328 sterol group Chemical group 0.000 claims abstract description 12
- 125000002091 cationic group Chemical group 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- -1 carboxylate salts Chemical class 0.000 claims description 20
- 229920000247 superabsorbent polymer Polymers 0.000 claims description 20
- 230000000845 anti-microbial effect Effects 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 230000002378 acidificating effect Effects 0.000 claims description 9
- 239000000835 fiber Substances 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 5
- 206010021639 Incontinence Diseases 0.000 claims description 3
- 235000021485 packed food Nutrition 0.000 claims description 3
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 235000015278 beef Nutrition 0.000 claims description 2
- 235000013365 dairy product Nutrition 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 235000015277 pork Nutrition 0.000 claims description 2
- 244000144977 poultry Species 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 18
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract description 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract description 2
- 230000003278 mimic effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 16
- 125000000217 alkyl group Chemical group 0.000 description 15
- 239000004744 fabric Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 238000010348 incorporation Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 9
- 239000000178 monomer Substances 0.000 description 8
- 239000004599 antimicrobial Substances 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 7
- 230000002209 hydrophobic effect Effects 0.000 description 7
- 125000006239 protecting group Chemical group 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000004429 atom Chemical group 0.000 description 6
- 229920002678 cellulose Polymers 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000004583 superabsorbent polymers (SAPs) Substances 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 210000001124 body fluid Anatomy 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 125000001188 haloalkyl group Chemical group 0.000 description 5
- 125000005647 linker group Chemical group 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000006386 neutralization reaction Methods 0.000 description 5
- 229920000098 polyolefin Polymers 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 125000003282 alkyl amino group Chemical group 0.000 description 4
- 125000005096 aminoalkylaminocarbonyl group Chemical group 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010040070 Septic Shock Diseases 0.000 description 3
- 206010044248 Toxic shock syndrome Diseases 0.000 description 3
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 125000002431 aminoalkoxy group Chemical group 0.000 description 3
- 125000004103 aminoalkyl group Chemical group 0.000 description 3
- 125000005123 aminoalkylcarboxy group Chemical group 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 3
- 125000005416 guanidinoalkyloxy group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 125000004423 acyloxy group Chemical group 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000007822 coupling agent Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- YDYLISNLJUDIGF-GXDYCHSMSA-N n-[(4r)-4-[(3r,5s,7r,8r,9s,10s,12s,13r,14s,17r)-3,7,12-tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine Chemical compound C([C@H]1C[C@H]2OCCCN)[C@H](OCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCNCCCCCCCC)[C@@]2(C)[C@@H](OCCCN)C1 YDYLISNLJUDIGF-GXDYCHSMSA-N 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 235000013580 sausages Nutrition 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010557 suspension polymerization reaction Methods 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- 125000006002 1,1-difluoroethyl group Chemical group 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 125000001769 aryl amino group Chemical group 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 239000002812 cholic acid derivative Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 229920003020 cross-linked polyethylene Polymers 0.000 description 1
- 239000004703 cross-linked polyethylene Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Definitions
- the present invention relates to the use of ceragenin compounds with articles that incorporate absorbent polymers.
- a superabsorbent polymer is a polymer that can absorb and retain extremely large amounts of a liquid relative to its own mass.
- a superabsorbent polymer may absorb 500 times its weight (from 30-60 times its own volume).
- the ability of a superabsorbent polymer to absorb water depends on the ionic concentration of the aqueous solution being absorbed.
- Saline solutions are less absorbed than distilled water. For example, a saline solution of 0.9% is absorbed by a superabsorbent polymer on the order of 50 times the polymer's weight.
- the total absorbency and swelling capacity are controlled by the type and degree of cross-linkers used to make the polymer.
- Superabsorbent polymers are commonly made from polymerizing acrylic acid blended with sodium hydroxide in the presence of an initiator to form a poly-acrylic acid sodium salt (sometimes referred to as sodium polyacrylate).
- the present invention relates to absorbent articles (e.g., diapers, hygiene products, absorbent packaging for food) that include an absorbent polymer and a ceragenin compound associated together with a support structure.
- Ceragenin compounds are anti-microbial compounds that have cationic groups attached to a sterol backbone. The compounds mimic the three dimensional structure of naturally occurring antimicrobial peptides and provide a natural mechanism of killing microbes.
- the water dissolves all or a portion of the ceragenin compound.
- the ceragenin compounds are only "activated” in the presence of moisture. Once dissolved in solution, the ceragenin compound can inhibit microbial growth for a sustained period of time (e.g., days, weeks, months or years).
- the ceragenin compound When the ceragenin compound is dissolved into a fluid during use, the fluid is retained in the absorbent polymer, thereby incorporating or maintaining incorporation of the ceragenin compound into the absorbent polymer. However, despite the incorporation of the ceragenin into the absorbent polymer (i.e., via the water), the ceragenin compound remains in fluid contact with microbes in the vicinity of the absorbent polymer. Microbes that migrate into the polymer come into contact with the ceragenin compound and are killed. Alternatively, or in addition, ceragenin molecules can elute out of the absorbent polymer and kill microbes in fluid contact with the absorbent polymer.
- the association of the ceragenin compound with the absorbent polymer provides control over the location and/or release of the ceragenin molecule while still effectively killing microbes.
- the hydrophobicity of the ceragenin can be selected to control the rate and/or extent that the ceragenin compound is retained or released from the absorbent polymer. Matching the hydrophobicity of the absorbent polymer to the ceragenin keeps the ceragenin in the absorbent polymer and creating a mismatch in hydrophobicity causes the ceragenin to be eluted. Thus, elution or retention can be selected.
- the ceragenin compound can continuously kill microbes at a high rate when the ceragenin is non-convalently attached to the absorbent polymer. Associating the ceragenin compound non-covalently through hydrophobic/hydrophilic interactions allows the controlled retention and/or release of the ceragenin compounds without the inactivation that occurs from covalent tethering.
- the ceragenin compound can be incorporated into the absorbent article by (i) incorporating the ceragenin into the absorbent polymer, (ii) intimately mixing the ceragenin with the absorbent polymer (e.g., in dry form), and/or (iii) incorporating the ceragenin compound into a supporting structure of the article (e.g., a fabric sheet) that is in fluid communication with water absorbed by the absorbent polymer during use of the article.
- the ceragenin compounds can be incorporated into the absorbent article and remain stable during storage. Stability can be achieved using the absorbent polymer in dry form or selecting ceragenins that are stable in the environment in which the absorbent article is stored. The stability of the ceragenin compound can give the article a shelf life of weeks, months, or even years.
- the stability of the ceragenin compounds can also be selected to facilitate manufacturing of the absorbent article.
- stable ceragenin compounds can be incorporated into an absorbent article at a point during manufacturing prior to the article being exposed to high temperatures that would render other microbial agents ineffective.
- the stability of the ceragenin compounds facilitates both the manufacture and use of the ceragenin compounds in absorbent articles.
- the absorbent articles can be used in diapers, hygiene products, wound care products (e.g., self adhesive bandages), and packaged foods.
- the absorbent article may be a disposable infant diapers, feminine hygiene product, a sanitary napkin, a panty liner, a tampon, a product for adult incontinence, a personal care wipe, a household wipe, or the like.
- ceragenin compounds are relatively inexpensive to make and can therefore be used in disposable products such as diapers and hygiene products. If desired, the ceragenin compounds can also be configured to gradually decompose to nontoxic compounds that won't build up in the environment.
- Figure 1 illustrates example ceragenin compounds.
- Figure 2 shows a diaper of the present invention in plan view.
- Figure 3 shows the diaper of FIG. 2 in cross section taken along line II- II;
- Figure 4 illustrates an adhesive bandage
- Ceragenin compounds also referred to herein as cationic steroidal antimicrobial compounds (CSAs) are synthetically produced small molecule chemical compounds that include a sterol backbone having various charged groups (e.g., amine and cationic groups) attached to the backbone.
- the backbone can be used to orient the amine or guanidine groups on one face, or plane, of the sterol backbone.
- Scheme I a scheme showing a compound having primary amino groups on one face, or plane, of a backbone is shown below in Scheme I:
- Ceragenins are cationic and amphiphilic, based upon the functional groups attached to the backbone. They are facially amphiphilic with a hydrophobic face and a polycationic face.
- the antimicrobial ceragenin compounds described herein act as anti-microbial agents (e.g., anti- bacterials, anti-fungals, and anti-virals). It is believed, for example, that the antimicrobial ceragenin compounds described herein act as anti-bacterials by binding to the outer cellular membrane of bacteria and other microbes and inserting into the cell membrane forming a pore that allows the leakage of ions that are critical to the microbe's survival and leading to the death of the affected microbe.
- the anti-microbial ceragenin compound described herein may also act to sensitize bacteria to other antibiotics.
- concentrations of the anti-microbial ceragenin compounds below the corresponding minimum bacteriostatic concentration the ceragenins cause bacteria to become more susceptible to other antibiotics by increasing the permeability of the outer membrane of the bacteria.
- the charged groups are responsible for disrupting the bacterial cellular membrane, and without the charged groups, the ceragenin compound cannot disrupt the membrane to cause cell death or sensitization.
- An example of a ceragenin compound is shown below at Formula I.
- the R groups on Formula I can have a variety of different functionalities, thus providing the ceragenin compound with different properties.
- ceragenin compounds having hydrolysable linkages are illustrated in Figure 1. As explained more fully below, ceragenins with hydrolysable linkages can be advantageous to prevent the ceragenins from persisting beyond a useful period of time.
- the absorbent articles of the invention include a support structure that incorporates an absorbent polymer and an associated ceragenin compound.
- the support structure can have any number of layers and/or configuration of layers to provide a support structure into which an absorbent polymer may be incorporated (i.e., deposited on or integrated within).
- the ceragenin compound is associated with the absorbent polymer in the sense that water absorbed by the polymer will be in fluid contact with the ceragenin compound.
- the absorbent articles may have several surfaces.
- articles may include inner and outer layers that "sandwich" an absorption layer.
- the inner shell and outer shell layers and the absorption layer can form several surfaces including a body facing surface (on a first outside shell layer), an outer shell layer (on the outside surface opposite he body facing surface), interfacial surfaces between or within the shell layers; surfaces of an absorbent inner layer.
- the body facing surface includes a material and/or configuration that wicks fluids away from skin and toward the absorption layer.
- the material used for a support structure will depend on the absorbent article being manufactured.
- the material may be a cellulose-containing substrate, such as a moisture absorbent fabric of the type commonly used for diapers.
- a moisture absorbent fabric of the type commonly used for diapers.
- fabrics are well known in the art and are preferably used in combination with a super absorbent polymeric material.
- ceragemom compounds in conventional cotton or fabrics.
- the support structure may include materials that are woven or non-woven.
- nonwoven includes spunbond, meltblown, coformed materials, hydroentangled fibers, needle punched or felted nonwovens, wet laid, dry laid fibers, and composites of said fibrous networks. While nonwoven materials are commonly fibrous materials, for the purpose of this disclosure a “nonwoven” may be a foam material, except as specified.
- the three basic layers are not necessarily discrete; and one basic layer may blend with another, or one basic layer may serve the purpose of another by varying the composition or density of the components.
- the outer shell 14 may be a highly densified outer portion of absorbent pad 12.
- the layers of the support structure may be bonded together using adhesives, ultrasonic bonding, heating, stitching, and similar methods. In some embodiments of the invention, portions of layers or entire layers are left unbonded.
- absorbent articles may include fasteners, elastic elements, and containment flaps to facilitate proper fit and avoid leakage.
- the support structure includes at least one absorbent polymer that can absorb water or other fluid capable of dissolving the ceragenin compound.
- the absorbent polymer includes a superabsorbent polymer.
- the superabsorbent polymer may have a composition and configuration that causes it to absorb a substantially larger amount of fluid relative to its own mass, (e.g., sodium polyacrylates).
- the absorbent polymer may include natural polymers such as cotton, cellulose, and cellulose derivatives. Also included are synthetic polymers such as viscose rayon, polypropylene, polyethylene, nylon, polyacrylates, polyesters, and polyurethanes or any blends or mixtures of above.
- the present invention can be incorporated into any article that includes an absorbent polymer and is typically used in a non-sterile environment.
- the absorbent article may be a personal hygiene device including a disposable infant diaper, a feminine hygiene product, a sanitary napkin, a panty liner, a tampon, a product for adult incontinence, or the like.
- the article may be a personal care wipe or a household wipe, or the like.
- the article may be an absorbable pad used in health care to maintain a barrier between a surface and the bodily fluids of a patient (e.g., a Chux underpad).
- the absorbent article may also be a food grade absorption pad packaged with a food product such as, but not limited to fruit (e.g., berries) or meat (e.g., whole meat poultry, fish, pork, or beef) vegetables, and/or dairy products.
- a food product such as, but not limited to fruit (e.g., berries) or meat (e.g., whole meat poultry, fish, pork, or beef) vegetables, and/or dairy products.
- Foods packaged with the absorbing articles described herein can reduce spoilage and disease caused by microbe that contaminate food. Surprisingly, even where ceragenins elute too slowly to properly kill a microbial population, by placing the microbes in fluid contact with the absorbant polymer, microbes have been found to migrate into the polymer and be killed, which increases the safety of using the ceragenins in close proximity to food products.
- Ceragenin compounds incorporated into the absorbent polymer can be non- covalently associated with the polymer.
- the CSA can leach or elute from the polymer.
- CSAs are generally soluble in water, and CSAs can be associated with polymers to control release rates. Selection of appropriate polymer and CSA structures allows for an extended period of release of the CSA.
- the chain extending from the amine at C17 carbon can be tailored to allow varied rates of elution from the absorbent polymer.
- Exemplary chains included, lipids, hydrophic chains (e.g., aliphatic), hydrophilic (e.g., polyethyleneoxide), or any chain that interacts with the polymer is a way that allows modification of the rate of elution. Longer chain lengths will retain the CSA within the polymer matrix (in particular the hydrophobic domains).
- Suitable CSA examples include those compounds illustrated in FIG. 1. Those labeled CSA-13, CSA-92, CSA-102, and CSA- 113.
- CSA-102 with a siloxane group can provide a means of covalent incorporation into silicone polymers.
- CSA- 113 with an acrylamide group can provide a means of covalent incorporation into acrylic -based polymers, including superabsorbents.
- CSA-92 with a long hydrophobic tail (C 16 I1 ⁇ 2) can be compatible with polyolefins, or copolymerized with olefins.
- the particular CSAs incorporated into the absorbent polymer may be soluble or partially soluble in aqueous solutions. Additionally, CSAs when blended with the water and the appropriate surfactant can be handled in the form of gels, or emulsions.
- Block copolymers based on ethylene oxide and/or propylene oxide in particular PluronicTM -type surfactants are especially useful for this purpose.
- PluronicTM is a product of BASF, a business with offices in Port Arthur, Texas, USA.
- Ceragenin compounds can be incorporated into the diaper at any suitable step during manufacture.
- the super-absorbent polymer, or the fluff pulp, or both can be brought into contact with a solution of ceragenins by immersion, spraying, printing, or coating, etc; the solvent is separated from the treated polymeric material by soaking, evaporation, or centrifugation, etc.
- the polymeric materials and absorbent materials are then dried by utilizing forced hot air, oven drying, air at room temperature, microwave drying, or the use of heated drying drums, vacuum chambers, etc. In some manufacturing systems the normal air flow and temperature sufficiently dry the substrate without a discrete drying process.
- a bale or roll of dense cellulose pulp is "opened” or “fiberized” to achieve a soft, absorbent fluff pulp.
- water is sprayed into the fluff pulp reduce static charge.
- a ceragenin suspension or solution replaces or augments the water spray, thereby incorporating the ceragenin into the fluff pulp.
- the ceragenin spray can be pulsed or zoned so that certain regions of the absorbent pad can have more ceragenin than other areas.
- the ceragenin can be incorporated into an absorbent pad or other device during its manufacture.
- absorbent pad or other device during its manufacture.
- a solution or suspension that contains ceragenins.
- the bottom of the conveyor may be perforated, and as the pad material may be sprayed onto the belt.
- a vacuum may be applied from below so that the fibers are pulled down to form a flat pad.
- a solution containing ceragenin is sprayed onto the top of the flat pad after it is formed.
- a further alternative involves the application of ceragenin solutions or suspensions to an absorbent article as the article itself is assembled or manufactured; this facilitates applying the ceragenin in specified zones on the article.
- ceragenin solutions or suspensions For example, for a diaper it may be desired to apply the ceragenin towards the front 23 or towards the rear 21 of the diaper; and the CSA solution or suspension can be sprayed or printed in the desired region of the diaper.
- Nonwovens and films are used in various parts of absorbent articles such as diapers.
- inner layer 13 of diaper 10 typically comprises a nonwoven or foraminous film.
- absorbent fabric encompasses nonwoven or foraminous films that are intended to absorb liquid.
- ceragenin compounds may be incorporated into the absorbent fabric in conventional fashion, such as by passage of an absorbent fabric from a supply roll, into a pad bath containing an appropriate concentration of the CSA in solution, through a nip roll to remove excess liquid, and into a dryer to dry the fabric at temperatures adequate to remove excess water.
- ceragenin compounds can be incorporated by passage of a nonwoven web or film through a bath of antimicrobial in a water or water/glycerine bath, the concentration of the antimicrobial being such as to provide the desired effective amount thereof.
- the impregnated fabric is then subjected to drying by passage through a dryer, typically through a stack of steam cans maintained at a suitable temperature that drying of the fabric may occur at any temperature at which the CSA compounds are stable, and which will evaporate any water or alcohol in the solution.
- the temperature can be in a range from 80-120 °C.
- the dry, finished absorbent fabric is then prepared for conversion into an absorbent product; it is rolled, cut to size, and stored, wrapped in plastic bags or the like.
- Ceragenin compounds are known to be soluble in water.
- ceragenin compounds are also soluble in such materials as ethanol (and other alcohols), propylene glycol, glycerine, and polyols, or mixtures thereof with or without water can be used in incorporate compounds into the absorbent material.
- ceragenins can be applied as gels, emulsions, suspensions, and in dry form.
- ceragenin is incorporated into an absorbent polymer during its formation.
- Superabsorbent polymers can commonly be made from the polymerization of acrylic acid blended with sodium hydroxide in the presence of an initiator to form a polyacrylic acid sodium salt (sometimes referred to as sodium polyacrylate).
- Other materials are also used to make a superabsorbent polymer, such as, for example, polyacrylamide copolymer, ethylene maleic anhydride copolymer, cross- linked carboxymethylcellulose, polyvinyl alcohol copolymers, cross-linked polyethylene oxide, and starch grafted copolymer of polyacrylonitrile.
- Exemplary processes for forming super-absorbent polymers include suspension polymerization and solution polymerization. In suspension polymerization the water based reactant is suspended in a hydrocarbon based solvent. The solution process uses a water based monomer solution to produce a mass of reactant polymerized gel.
- the ceragenin can be included in the monomer blend during superabsorbent manufacture.
- the ceragenin in final polymer can be noncovalently incorporated into the polymer and will accordingly elute when contacted with water.
- Ceragenins with polymerizable groups, such as the acrylamido group on CSA-113 can copolymerize with the acrylic acid monomer, which results in a result in a CSA covalently-bonded to the polymer.
- a CSA solution, gel, emulsion, dry powder, or suspension may be applied to the superabsorbent polymer as a spray.
- the CSA-containing spray can be applied while the superabsorbent is fluidized in an air stream, as the superabsorbent is being blended with fluff pulp, or in the already blended superabsorbent / fluff.
- a drying step may be required.
- CSAs with polymerizable groups can be covalently bonded to the polymer by incorporating it into the monomer mix.
- Ceragenins can also be immobilized or permanently attached to a substrate surface, while retaining activity of the ceragenins. This can be accomplishing by direct bonding of a ceragenin to the surface, or by means of an adhesion layer, a coupling agent, or tether.
- ceragenins can have polymerizable groups, such as the acrylamido group on CSA-113, or an olefin group with an active site that can be copolymerized into the polymer.
- Nonwoven materials such as, for example, nylon, polyester, polyethylene, or polypropylene manufactured by mechanically, chemically, or thermally, heat melting, interlocking the plastic fibers.
- the ceragenin compounds can be incorporated into the one or more of the layers of an article with are mixed with monomers that are used for an inner layer. The monomers are then reacted and polymerized or cured to form a polymer with the ceragenin associated with or covalently bonded to the polymer.
- the ceragenin used can be modified or unmodified or a conjugate of the ceragenin and another compound to facilitate formation of a slow eluting material.
- the CSA is added to molten polymer prior to the polymer being formed as a film or nonwoven.
- CSA-92 is dissolved in propylene glycol and added to a molten polypropylene near the end of an extruder, just prior to the polypropylene being formed into a spunbond nonwoven.
- the CSA will tend to migrate towards the surface as the fibers are being drawn.
- a polyolefin-based inner layer nonwoven or film, as manufactured, may lack suitable sites to anchor CSA.
- Methods of priming the polyolefin such as flame treatment, corona treatment, plasma treatment, and acid washes are known in the art to facilitate printing and adhesive bonding to polyolefins. Such methods can also be used to facilitate bonding the CSA to the inner layer.
- the priming treatment is advantageously done shortly before the CSA is added to the nonwoven or film.
- Suitable CSA compounds for use in the inner layer can be, for example, conjugates of any of the monomers or other compounds that function as monomers, conjugates with modifiers, conjugates with selected solubility properties, or unconjugated CSAs.
- the CSA compounds can be applied by any suitable method, such as contacting the film with a suitable solution of a CSA compound that coats or associates with the surface.
- Certain polymer compositions used for inner layers may contain reactive sites that are available for direct attachment or attachment through a coupling agent or a tether (e.g., PEG).
- CSA compounds can be incorporated through a conjugate that is attached, solubilized, or otherwise incorporated into the inner layer.
- a ceragenin compound can have hydrolysable linkages that attach the cationic groups to the sterol group (e.g., ester bonds). Hydrolysis of these linkages inactivates the ceragenin.
- an acid can be added to achieve a pH less than 6, 5.5, 5, or 4.5 and optionally greater than 2, 2,5, or 3 or a range thereof. Stability before use is important to give a desired shelf life and instability during and after use can be desirable to prevent long term accumulation of ceragenins in biological systems.
- ceragenins that include hydrolysable linkages includes, but is not limited to suitable ceragenin compounds that can be used in this embodiment, include but are not limited to, CSA-32, CSA-33, CSA-34, CSA-35, CSA-41, CSA-42, CSA-43, CSA- 44, CSA-45, CSA-47, CSA-49, CSA-50, CSA-51, CSA-52, CSA-56, CSA-141, CSA- 142.
- the acid can be a fluid or a solid, (e.g., acetic acid or citric acid, respectively) and can be blended with a superabsorbent / pulp blend.
- the degree of neutralization of the superabsorbent polymer may be adjusted to improve the stability of the ceragenin.
- the degree of neutralization of the superabsorbent polymer can be adjusted during its manufacturing process, or subsequently.
- the ceragenin can be suspended or dissolved in an acidic solution; and when the ceragenin suspension or solution is added to the superabsorbent the degree of neutralization of the superabsorbent would thereby be adjusted.
- acidic sites may be optionally provided to stabilize the ceragenin active sites, and extend the duration of the antimicrobial effect.
- Cellulose materials which are common in diaper absorbents, have numerous sites, particularly -OH sites, to which acidic functional groups can be added, such as, for example, carboxy groups (or moieties with carboxy groups or acidic groups).
- the polymer materials used in the inner layer may have reactive sites for attachment of acidic functional groups.
- carboxy or other acidic groups can be added in a similar manner.
- Many superabsorbent polymers for use in diapers are partially neutralized, crosslinked, acrylic acid-based polymers.
- the degree of neutralization of the polymer correlates to the carboxylic acid (R-COOH) versus carboxylate (R-COO- X+) ratio.
- the degree of neutralization of the superabsorbent polymer can be adjusted to provide sufficient acidic sites for the ceragenins. This can increase the duration of the antimicrobial activities during storage, particularly in a moist or humid environment, and also during use of the article.
- acid sites can be provided by infiltrating the absorbent or nonwoven polymer with an acidic substance, which is retained or elutes sufficiently slow to maintain an acidic environment.
- the acidity of the absorbent can be measured using any suitable method. As an example, a saturating solution of the polymer can be tested or the whole absorbent article can be tested.
- a diaper is generally depicted in Fig. 2 and 3; the diaper 10 includes three basic layers: (i) an outer shell 14; (ii) an absorbent pad 12; and (iii) an inner layer 13.
- the diaper also includes a perimeter region 15, a front region 23, a crotch portion 22, and a rear portion 21. Fasteners 11 are disposed on the rear portion 21.
- the outer shell 14 typically comprises a film and/or nonwoven fabric. An important function of the outer shell 14 is to retain liquid and soil in the diaper.
- the outer shell 14 may permit transpiration of water vapor, i.e., it may be breathable, and help provide a drier environment within the diaper.
- the absorbent pad 12 absorbs, distributes, and retains body fluids.
- the absorbent pad 12 commonly comprises a blend of superabsorbent polymers and fluff pulp.
- the absorbent pad 12 may comprise tissue layers, synthetic polymer fibers, nonwoven fibers, odor absorbents, color indicators, and adhesives.
- the absorbent pad 12 may be a homogeneous layer, or it may comprise multiple layers. The composition and/or density of the absorbent may vary in the x, y, or z directions.
- the absorbent pad 12 may include strips, or zones, or pockets of different composition or density than adjacent portions of the absorbent pad 12.
- a common component of the absorbent pad is fluff pulp, i.e., fluffed cellulose pulp, typically made from wood, especially softwood. Such absorbent fluff pulp is commercially available in bale or roll form.
- the absorbent pad 12 includes 0- 99% fluff pulp.
- the absorbent pad 12 includes 1- 100% superabsorbent polymer.
- the absorbent pad 12 comprises 15-60% superabsorbent polymer and 40-85% fluff pulp.
- the absorbent pad may contain synthetic absorbent cellulose fibers, such as rayon. Synthetic fibers, such as polyesters and polyolefins, may also be used to good effect. In some embodiments the absorbent fibers are treated with surfactant agents.
- the inner layer 13 separates the wearer of the diaper from the absorbent pad 12. The inner layer 13 absorbs fluid and transfers the fluid to the absorbent pad 12. As such, the inner layer 13 is fluid permeable.
- the inner layer 13 comprises a first layer, which may comprise a film or nonwoven. In various configurations the first layer is foraminous, and/or may be treated to modify its hydrophilic / hydrophobic balance.
- the inner layer 13 further comprises an acquisition layer, i.e., a layer that is configured to rapidly intake and distribute fluid.
- the acquisition layer is typically a nonwoven material is positioned adjacent the first layer of the inner layer 13.
- the inner layer has a body-contacting surface, and a reverse surface, (not shown) the reverse surface facing towards the adjacent absorbent pad.
- the absorbent pad 12 in diapers is specially designed to absorb, distribute and retain body fluids.
- the outer shell 14 functions as a barrier to liquid helps prevent leakage. Diapers are frequently made by a multi-step process in which the absorbent pad 12 is formed, then attached to an inner layer 12, and an outer shell 14 as a continuous "sausage".
- the layers may be trimmed using a water jet, die cut, or other means.
- elastics, fasteners 11, and barrier cuffs may also be added to the diaper.
- the inner layer 12 and the outer shell 14 are sealed together along their perimeter 15 by application of heat, adhesives, or ultrasonic vibrations. The continuous sausage is cut into separate diapers, and the diapers are packaged.
- FIG. 4 illustrates a bandage 30 that can be used in wound care.
- Bandage 30 includes an elongate strip 32 of a flexible material that extends from a first end 34 to a second end 36.
- Strip 32 includes a plurality of perforations that allow the bandage to breath.
- Outer sections 34a and 34b have a biocompatible adhesive that allows the bandage to be attached to a person's skin.
- Center portion 40 includes a gauze adsorbent and/or a super adsorbent polymer and a ceragenin compound. Ceragenin compounds can optionally be applied to outer sections 34a and 34b or an upper surface if desired.
- bandage 30 can have a different shape or size according to sizes and shapes known in the art.
- ceragenins can be associated with adsorbents for other wound care products such as, but not limited to gauze and wrapping.
- the primary function of a personal absorbent product is to absorb body fluids and prevent leakage. In the process of absorbing body fluids it is desired that the fluid the products absorb does not become a haven or breeding medium for microorganisms. Additionally, in the warm, moist environment microorganisms on the wearer's skin can proliferate. CSA, properly disposed in an absorbent article can restrict the growth of such microorganisms. [0067] Microorganisms, and bacteria in particular, are undesirable because they catalyze the breakdown of substances in the urine, creating products that cause a strong odor and skin irritation, by limiting microbial growth CSA can limit such problems.
- TSS toxic shock syndrome
- the concentration of CSA associated the absorbent article is dependent upon the particular CSA compounds and absorbent composition.
- the concentration in general, should be at least the minimum inhibitory concentration (MIC) of the CSA, at or near the surface of the absorbent material.
- MIC is defined the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. This is a well documented and accepted diagnostic test.
- the MIC of the particular CSA can be determined, and its properties with the absorbent matched to produce at least an MIC concentration for the target bacteria at or near the surface of the absorbent. Examples of MIC values for certain CSA compounds can be found at C. Li, et al. "Antimicrobial Activities of Amine- and Guanidine- Functionalized Cholic Acid Derivatives" Antimicrobial Agents and Chemotherapy, Vol. 43, No. 6, June 1999, p. 1347-1349.
- the ceragenin compound may have a structure as shown in Formula I:
- each of fused rings A, B, C, and D is independently saturated, or is fully or partially unsaturated, provided that at least two of A, B, C, and D are saturated, wherein rings A, B, C, and D form a ring system; each of m, n, p, and q is independently 0 or 1 ; each of Ri through R 4 , R 6 , R 7 , Rn , R 12 , R15, R1 ⁇ 2, R17, and R 18 is independently selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted (d-do) alkyl, (d-do) hydroxyalkyl, (d-C 10 ) alkyloxy-( d-C 10 ) alkyl, (d-C 10 ) alkylcarboxy-( d-do) alkyl, (d-do) alkylamino-( d-do) alkyl, (d-do) alkylamin
- R 5 , Rg, R9, Rio, R13, and R14 is independently deleted when one of fused rings A, B, C, or D is unsaturated so as to complete the valency of the carbon atom at that site, or selected from the group consisting of hydrogen, hydroxyl, a substituted or unsubstituted (d-do) alkyl, (d-do) hydroxyalkyl, (d-do) alkyloxy-(Ci- do) alkyl, a substituted or unsubstituted (d-do) aminoalkyl, a substituted or unsubstituted aryl, (d-do) haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, oxo, a linking group attached to a second steroid, a substituted or unsubstituted (d-do) aminoalkyloxy, a substituted or unsubsti
- R 6 , R7 , Rn, R 12 , R15, R 16 , R 17 , and Rig are independently selected from the group consisting of a substituted or unsubstituted (d-do) aminoalkyl, a substituted or unsubstituted (d-do) aminoalkyloxy, (d-do) alkylcarboxy-( d-do) alkyl, (d-do) alkylamino- (d-C 10) alkylamino, (d-do) alkylamino-(Ci-Cio) alkylamino- (d-C 10) alkylamino, a substituted or unsubstituted (d-do) aminoalkylcarboxy, a substituted or unsubstituted arylamino(Ci-Cio) alkyl, a substituted or unsubstituted (d-d
- R 3 , R 7 , or R 12 may independently include a cationic moiety attached to the Formula I structure via a hydrolysable linkage.
- a tail moiety may be attached to Formula I at R 17 .
- the tail moiety may be charged, uncharged, polar, non-polar, hydrophobic, amphipathic, and the like.
- a "ring" as used herein can be heterocyclic or carbocyclic.
- saturated used herein refers to the fused ring of Formula I having each atom in the fused ring either hydrogenated or substituted such that the valency of each atom is filled.
- unsaturated used herein refers to the fused ring of Formula I where the valency of each atom of the fused ring may not be filled with hydrogen or other substituents. For example, adjacent carbon atoms in the fused ring can be doubly bound to each other. Unsaturation can also include deleting at least one of the following pairs and completing the valency of the ring carbon atoms at these deleted positions with a double bond; such as R5 and R9; Rg and R ⁇ ; and R 13 and R 14 .
- unsubstituted refers to a moiety having each atom hydrogenated such that the valency of each atom is filled.
- halo refers to a halogen atom such as fluorine, chlorine, bromine, or iodine.
- An alkyl group is a branched or unbranched hydrocarbon that may be substituted or unsubstituted.
- branched alkyl groups include isopropyl, sec- butyl, isobutyl, tert-butyl, sec-pentyl, isopentyl, tert-pentyl, isohexyl.
- Substituted alkyl groups may have one, two, three or more substituents, which may be the same or different, each replacing a hydrogen atom.
- Substituents are halogen (e.g., F, CI, Br, and I), hydroxyl, protected hydroxyl, amino, protected amino, carboxy, protected carboxy, cyano, methylsulfonylamino, alkoxy, acyloxy, nitro, and lower haloalkyl.
- halogen e.g., F, CI, Br, and I
- hydroxyl protected hydroxyl
- substituted used herein refers to moieties having one, two, three or more substituents, which may be the same or different, each replacing a hydrogen atom.
- substituents include but are not limited to halogen (e.g., F, CI, Br, and I), hydroxyl, protected hydroxyl, amino, protected amino, carboxy, protected carboxy, cyano, methylsulfonylamino, alkoxy, alkyl, aryl, aralkyl, acyloxy, nitro, and lower haloalkyl.
- halogen e.g., F, CI, Br, and I
- An aryl group is a C 6 -2o aromatic ring, wherein the ring is made of carbon atoms (e.g., C 6 -C 14 , C 6 -io aryl groups).
- haloalkyl include fluoromethyl, dichloromethyl, trifluoro methyl, 1, 1-difluoroethyl, and 2,2-dibromoethyl.
- An aralkyl group is a group containing 6-20 carbon atoms that has at least one aryl ring and at least one alkyl or alkylene chain connected to that ring.
- An example of an aralkyl group is a benzyl group.
- a linking group is any divalent moiety used to link one compound to another.
- a linking group may link a second compound to a compound of Formula I.
- An example of a linking group is (C Cio) alkyloxy-( Ci-Cw) alkyl.
- Amino-protecting groups are known to those skilled in the art. In general, the species of protecting group is not critical, provided that it is stable to the conditions of any subsequent reaction(s) on other positions of the compound and can be removed at the appropriate point without adversely affecting the remainder of the molecule. In addition, a protecting group may be substituted for another after substantive synthetic transformations are complete. Clearly, where a compound differs from a compound disclosed herein only in that one or more protecting groups of the disclosed compound has been substituted with a different protecting group, that compound is within the disclosure. Further examples and conditions are found in T. W. Greene, Protective Groups in Organic Chemistry, (1st ed., 1981, 2nd ed., 1991).
- ceragenin compounds described herein preserve certain stereochemical and electronic characteristics found in steroids.
- the term "single face,” as used herein, refers to substituents on the fused sterol backbone having the same stereochemical orientation such that they project from one side of the molecule.
- substituents bound at R 3 , R 7 and R 12 of Formula I may be all ⁇ - substituted or a-substituted.
- the configuration of the moieties R 3 , R 7 and R 12 may be important for interaction with the cellular membrane.
- Compounds include but are not limited to compounds having cationic groups (e.g., amine or guanidine groups) covalently attached to a steroid backbone or scaffold at any carbon position, e.g., cholic acid.
- a group is covalently attached at anyone, or more, of positions R 3 , R 7 , and R 12 of the sterol backbone.
- a group is absent from anyone, or more, of positions R 3 , R 7 , and R 12 of the sterol backbone.
- Anti-microbial CSA compounds described herein may also include a tether or "tail moiety" attached to the sterol backbone.
- the tail moiety may have variable chain length or size and may be one of charged, uncharged, polar, non-polar, hydrophobic, amphipathic, and the like.
- a tail moiety may be attached at R 17 of Formula I.
- a tail moiety may include the heteroatom (O or N) covalently coupled to the sterol backbone.
- the tail moiety may, for example, be configured to alter the hydrophobicity/hydrophilicity of the ceragenin compound.
- Ceragenin compounds of the present disclosure having different degrees of hydrophobicity/hydrophilicity may, for example, have different rates of uptake into different target microbes.
- altering the hydrophobicity/hydrophilicity of the ceragenin compounds described herein may affect the retention of the ceragenin compounds in certain media.
- ring systems can also be used, e.g., 5-member fused rings.
- Compounds with backbones having a combination of 5- and 6-membered rings are also contemplated.
- Cationic functional groups e.g., amine or guanidine groups
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201180063891.XA CN103313597B (en) | 2010-11-03 | 2011-11-03 | Goods in conjunction with water absorbent polymer and Sai La Jining compound |
CA2816884A CA2816884C (en) | 2010-11-03 | 2011-11-03 | Articles incorporating absorbent polymer and ceragenin compound |
JP2013537838A JP6162042B2 (en) | 2010-11-03 | 2011-11-03 | Products incorporating absorbent polymers and ceragenin compounds |
EP11785852.2A EP2635118A1 (en) | 2010-11-03 | 2011-11-03 | Articles incorporating absorbert polymer and ceragenin compound |
BR112013010976A BR112013010976A2 (en) | 2010-11-03 | 2011-11-03 | "Articles incorporating absorbent polymer and ceragenin compound." |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45620410P | 2010-11-03 | 2010-11-03 | |
US61/456,204 | 2010-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012061651A1 true WO2012061651A1 (en) | 2012-05-10 |
Family
ID=45002138
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/059225 WO2012061648A1 (en) | 2010-11-03 | 2011-11-03 | Storage-stable, anti-microbial compositions including ceragenin compounds and methods of use |
PCT/US2011/059228 WO2012061651A1 (en) | 2010-11-03 | 2011-11-03 | Articles incorporating absorbert polymer and ceragenin compound |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/059225 WO2012061648A1 (en) | 2010-11-03 | 2011-11-03 | Storage-stable, anti-microbial compositions including ceragenin compounds and methods of use |
Country Status (8)
Country | Link |
---|---|
US (2) | US8691252B2 (en) |
EP (2) | EP2635118A1 (en) |
JP (1) | JP6162042B2 (en) |
CN (1) | CN103313597B (en) |
BR (2) | BR112013010977A2 (en) |
CA (2) | CA2816879C (en) |
RU (1) | RU2576459C2 (en) |
WO (2) | WO2012061648A1 (en) |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013013223A1 (en) * | 2011-07-20 | 2013-01-24 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
WO2013029055A1 (en) * | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
US9155746B2 (en) | 2011-09-13 | 2015-10-13 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9161942B2 (en) | 2011-09-13 | 2015-10-20 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
US9314472B2 (en) | 2012-10-17 | 2016-04-19 | Brigham Young University | Treatment and prevention of mastitis |
US9345655B2 (en) | 2011-12-21 | 2016-05-24 | Brigham Young University | Oral care compositions |
US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
US9943529B2 (en) | 2013-01-07 | 2018-04-17 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
US9943614B2 (en) | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
US10039285B2 (en) | 2012-05-02 | 2018-08-07 | Brigham Young University | Ceragenin particulate materials and methods for making same |
US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US10626139B2 (en) | 2014-02-27 | 2020-04-21 | Brigham Young University | Cationic steroidal antimicrobial compounds |
US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
US11286276B2 (en) | 2014-01-23 | 2022-03-29 | Brigham Young University | Cationic steroidal antimicrobials |
US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
US11739116B2 (en) | 2013-03-15 | 2023-08-29 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11278457B2 (en) | 2017-02-09 | 2022-03-22 | Hill-Rom Services, Inc. | Incontinence detection optimization using directional wicking |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4865855A (en) * | 1988-01-11 | 1989-09-12 | Kimberly-Clark Corporation | Antimicrobial absorbent food pad |
EP0341951A2 (en) * | 1988-05-09 | 1989-11-15 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
WO2003090799A1 (en) * | 2002-04-23 | 2003-11-06 | Stockhausen Gmbh | Water-absorbing polymer particles inhibiting the breakdown of body fluids, composites comprising the same and use thereof |
WO2004112852A1 (en) * | 2003-06-23 | 2004-12-29 | Beiersdorf Ag | Antimicrobial wounddressing |
WO2007134176A2 (en) * | 2006-05-10 | 2007-11-22 | Microban Products Company | Antimicrobial food pad |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4842593A (en) * | 1987-10-09 | 1989-06-27 | The Procter & Gamble Company | Disposable absorbent articles for incontinent individuals |
JP2877636B2 (en) * | 1992-11-18 | 1999-03-31 | 積水化成品工業株式会社 | Antibacterial drip sheet |
JP3044367B2 (en) * | 1995-11-13 | 2000-05-22 | 三洋化成工業株式会社 | Antimicrobial water-absorbing composition and method for producing the same |
US6767904B2 (en) * | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
JP5052730B2 (en) | 2000-08-15 | 2012-10-17 | ブリガム ヤング ユニバーシティ | Steroid-derived antibiotics |
US20050181082A1 (en) * | 2002-05-21 | 2005-08-18 | Fumiyuki Isami | Morinda citrifolla based antifungal formulations and methods |
DE10328261B4 (en) * | 2003-06-23 | 2007-10-25 | Beiersdorf Ag | Disinfecting coating with silver coating and its use |
WO2007089906A2 (en) * | 2006-02-01 | 2007-08-09 | Brigham Young University | Cationic steroid antimicrobial compositions for treating or preventing herpes infections |
US8558051B2 (en) * | 2007-07-18 | 2013-10-15 | The Procter & Gamble Company | Disposable absorbent article having odor control system |
EP2303026B1 (en) * | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
KR20110028372A (en) * | 2008-07-09 | 2011-03-17 | 보드 오브 리젠츠 오브 디 유니버시티 오브 네브라스카 | Functional micelles for hard tissue targeted delivery of chemicals |
US9533479B2 (en) * | 2008-09-18 | 2017-01-03 | Medline Industries, Inc. | Absorbent articles having antimicrobial properties and methods of manufacturing the same |
-
2011
- 2011-11-03 WO PCT/US2011/059225 patent/WO2012061648A1/en active Application Filing
- 2011-11-03 US US13/288,892 patent/US8691252B2/en active Active
- 2011-11-03 WO PCT/US2011/059228 patent/WO2012061651A1/en active Application Filing
- 2011-11-03 JP JP2013537838A patent/JP6162042B2/en not_active Expired - Fee Related
- 2011-11-03 BR BR112013010977A patent/BR112013010977A2/en not_active IP Right Cessation
- 2011-11-03 EP EP11785852.2A patent/EP2635118A1/en not_active Ceased
- 2011-11-03 CA CA2816879A patent/CA2816879C/en active Active
- 2011-11-03 EP EP11785538.7A patent/EP2635117B1/en active Active
- 2011-11-03 RU RU2013123892/13A patent/RU2576459C2/en not_active IP Right Cessation
- 2011-11-03 US US13/288,902 patent/US8784857B2/en not_active Expired - Fee Related
- 2011-11-03 CA CA2816884A patent/CA2816884C/en not_active Expired - Fee Related
- 2011-11-03 CN CN201180063891.XA patent/CN103313597B/en not_active Expired - Fee Related
- 2011-11-03 BR BR112013010976A patent/BR112013010976A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4865855A (en) * | 1988-01-11 | 1989-09-12 | Kimberly-Clark Corporation | Antimicrobial absorbent food pad |
EP0341951A2 (en) * | 1988-05-09 | 1989-11-15 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
WO2003090799A1 (en) * | 2002-04-23 | 2003-11-06 | Stockhausen Gmbh | Water-absorbing polymer particles inhibiting the breakdown of body fluids, composites comprising the same and use thereof |
WO2004112852A1 (en) * | 2003-06-23 | 2004-12-29 | Beiersdorf Ag | Antimicrobial wounddressing |
WO2007134176A2 (en) * | 2006-05-10 | 2007-11-22 | Microban Products Company | Antimicrobial food pad |
Non-Patent Citations (9)
Title |
---|
C. LI ET AL.: "Antimicrobial Activities of Amine- and Guanidine- Functionalized Cholic Acid Derivatives", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 43, no. 6, June 1999 (1999-06-01), pages 1347 - 1349 |
EMILY L. PERRY ET AL: "Assessing peri-implant tissue infection prevention in a percutaneous model", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 92B, 19 November 2009 (2009-11-19), pages 397 - 408, XP055017067, ISSN: 1552-4973, DOI: 10.1002/jbm.b.31528 * |
P B SAVAGE ET AL: "Thin Films Containing Ceragenins Prevent Biofilm Formation on Endotracheal Tubes", 9TH INTERNATIONAL FEDERATION OF INFECTION CONTROL CONGRESS, 14 October 2008 (2008-10-14), Santiago, Chile, pages 1 - 1, XP055016800, Retrieved from the Internet <URL:http://www.n8medical.com/PDF/EndotrachealTubePoster-IFIC.PDF> [retrieved on 20120118] * |
P B SAVAGE ET AL: "Use of a Ceragenin-Based Coating to Prevent Bacterial Colonization of Urinary Catheters", 48TH ANNUAL INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS & CHEMOTHERAPY, 26 October 2008 (2008-10-26), Washington DC, USA, pages 1 - 1, XP055016798, Retrieved from the Internet <URL:http://n8medical.com/PDF/CatheterCoatingPresentation.pdf> [retrieved on 20120118] * |
SAVAGE ET AL: "Antibacterial Activities of Thin films Containing Ceragenins", MICROBIAL SURFACES : STRUCTURE, INTERACTIONS, AND REACTIVITY, ACS, 30 May 2008 (2008-05-30), pages 65 - 78, XP009155636, DOI: 10.1021/BK-2008-0984.CH005 * |
See also references of EP2635118A1 |
T R FRITSCH ET AL: "In Vitro Activity of Nine Developmental Cationic Steroid Compounds (Ceragenins) against Clinical Isolates of Clostridium difficile", THE 46TH INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 27 September 2006 (2006-09-27), San Francisco, USA, pages 1 - 1, XP055016797, Retrieved from the Internet <URL:http://web.archive.org/web/20070307040637/http://www.ceragenix.com/6.pdf> [retrieved on 20120118] * |
T. W. GREENE: "Protective Groups in Organic Chemistry", 1981 |
X Z LAI ET AL: "Controlled Release of a Bactericidal Ceragenin-Polymer Conjugate", 46TH ANNUAL INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 27 September 2006 (2006-09-27), San Francisco, USA, pages 1 - 1, XP055016796, Retrieved from the Internet <URL:http://web.archive.org/web/20070307040930/http://www.ceragenix.com/2.pdf> [retrieved on 20120118] * |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9943614B2 (en) | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
WO2013013221A1 (en) * | 2011-07-20 | 2013-01-24 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
US8975310B2 (en) | 2011-07-20 | 2015-03-10 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
AU2012285818B2 (en) * | 2011-07-20 | 2015-07-02 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
AU2012285816B2 (en) * | 2011-07-20 | 2015-07-23 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
US9546195B2 (en) | 2011-07-20 | 2017-01-17 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
US10676501B2 (en) | 2011-07-20 | 2020-06-09 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
WO2013013223A1 (en) * | 2011-07-20 | 2013-01-24 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
WO2013029055A1 (en) * | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
US8945217B2 (en) | 2011-08-25 | 2015-02-03 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
US9155746B2 (en) | 2011-09-13 | 2015-10-13 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9161942B2 (en) | 2011-09-13 | 2015-10-20 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
US9345655B2 (en) | 2011-12-21 | 2016-05-24 | Brigham Young University | Oral care compositions |
US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
US10039285B2 (en) | 2012-05-02 | 2018-08-07 | Brigham Young University | Ceragenin particulate materials and methods for making same |
US9314472B2 (en) | 2012-10-17 | 2016-04-19 | Brigham Young University | Treatment and prevention of mastitis |
US10195215B2 (en) | 2013-01-07 | 2019-02-05 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
US9943529B2 (en) | 2013-01-07 | 2018-04-17 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US11739116B2 (en) | 2013-03-15 | 2023-08-29 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
US11286276B2 (en) | 2014-01-23 | 2022-03-29 | Brigham Young University | Cationic steroidal antimicrobials |
US10626139B2 (en) | 2014-02-27 | 2020-04-21 | Brigham Young University | Cationic steroidal antimicrobial compounds |
US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
US11253634B2 (en) | 2016-03-11 | 2022-02-22 | Brigham Young University | Cationic steroidal antibiotic compositions for the treatment of dermal tissue |
US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
Also Published As
Publication number | Publication date |
---|---|
US8691252B2 (en) | 2014-04-08 |
EP2635117B1 (en) | 2018-09-19 |
RU2576459C2 (en) | 2016-03-10 |
RU2013123892A (en) | 2014-12-10 |
CN103313597B (en) | 2016-06-29 |
CA2816879C (en) | 2019-06-11 |
CA2816884A1 (en) | 2012-05-10 |
US20120107382A1 (en) | 2012-05-03 |
BR112013010977A2 (en) | 2016-07-12 |
US8784857B2 (en) | 2014-07-22 |
BR112013010976A2 (en) | 2016-07-12 |
JP2014500741A (en) | 2014-01-16 |
US20120108561A1 (en) | 2012-05-03 |
JP6162042B2 (en) | 2017-07-12 |
CA2816884C (en) | 2019-04-02 |
WO2012061648A1 (en) | 2012-05-10 |
EP2635118A1 (en) | 2013-09-11 |
EP2635117A1 (en) | 2013-09-11 |
CA2816879A1 (en) | 2012-05-10 |
CN103313597A (en) | 2013-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2816884C (en) | Articles incorporating absorbent polymer and ceragenin compound | |
US8476483B2 (en) | Antibacterial sheet and absorbent article | |
JP4564921B2 (en) | Absorbent binder composition, method for producing the same, and article incorporating the same | |
JP5073753B2 (en) | Absorbent articles containing an organic zinc salt and an antibacterial agent or alkali metal chloride or alkaline earth metal chloride | |
KR100335554B1 (en) | Antimicrobial-coated hydrogel forming absorbent polymers | |
TW420706B (en) | Antimicrobial forming absorbent polymers and process for making the same | |
JP5021667B2 (en) | Absorbent article containing acidic superabsorbent and organic zinc salt | |
KR20170107964A (en) | Synthetic surfactant-free finish, sheet having synthetic surfactant-free finish, articles having sheet with synthetic surfactant-free finish, and related methods | |
JP6436795B2 (en) | Fumaric acid-containing fiber, fumaric acid-containing fiber assembly and absorber | |
US20100076389A1 (en) | Absorbent article including fragrance emitting layer | |
JP7431510B2 (en) | absorbent articles | |
MXPA00009682A (en) | Odor control in absorbent articles. | |
EP1750778A2 (en) | Absorbent articles with antimicrobial zones on coverstock | |
JP2017070515A (en) | Sheet for absorbent article, absorbent article, and manufacturing method thereof | |
JPH0568694A (en) | Absorptive article | |
JP5749980B2 (en) | Water-absorbent resin composition, absorber and absorbent article | |
JP2019528919A (en) | Absorbent article with pH controlled topsheet | |
CN103768640B (en) | Wound dressing and preparation method thereof | |
JP2019218429A (en) | Water-absorbing resin particles and absorbent article | |
JP6952648B2 (en) | Absorbent article |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11785852 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2013537838 Country of ref document: JP Kind code of ref document: A Ref document number: 2816884 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011785852 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112013010976 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 112013010976 Country of ref document: BR Kind code of ref document: A2 Effective date: 20130503 |