WO2012053006A8 - Improved oral fast dissolving films comprising combination of polymers and method of preparation thereof - Google Patents

Improved oral fast dissolving films comprising combination of polymers and method of preparation thereof Download PDF

Info

Publication number
WO2012053006A8
WO2012053006A8 PCT/IN2011/000715 IN2011000715W WO2012053006A8 WO 2012053006 A8 WO2012053006 A8 WO 2012053006A8 IN 2011000715 W IN2011000715 W IN 2011000715W WO 2012053006 A8 WO2012053006 A8 WO 2012053006A8
Authority
WO
WIPO (PCT)
Prior art keywords
combination
oral
polymers
preparation
water
Prior art date
Application number
PCT/IN2011/000715
Other languages
French (fr)
Other versions
WO2012053006A3 (en
WO2012053006A2 (en
Inventor
Rajesh Jain
Sarabjit Singh
Paramjit Singh
Mansi Saildesai
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of WO2012053006A2 publication Critical patent/WO2012053006A2/en
Publication of WO2012053006A8 publication Critical patent/WO2012053006A8/en
Publication of WO2012053006A3 publication Critical patent/WO2012053006A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to an oral film having reduced adherence to oral cavity comprising water-soluble polymer as an essential polymer base in combination with film former, wherein the ratio of water-soluble polymer to the film former is about 25: 1 to about 250: 1 that is suitable for delivering drugs from various pharmacological categories ranging from conventional small molecules to proteins or peptides. In particular the invention relates to oral films which are bioequivalent to conventional immediate release oral dosage forms and exhibiting one or more favorable properties such as fast dissolution time, improved drug loading, improved mechanical properties (burst strength, tensile strength, modules of elongation).
PCT/IN2011/000715 2010-10-18 2011-10-17 Improved oral fast dissolving films comprising combination of polymers and method of preparation thereof WO2012053006A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2887/MUM/2010 2010-10-18
IN2887MU2010 2010-10-18

Publications (3)

Publication Number Publication Date
WO2012053006A2 WO2012053006A2 (en) 2012-04-26
WO2012053006A8 true WO2012053006A8 (en) 2012-05-24
WO2012053006A3 WO2012053006A3 (en) 2012-08-02

Family

ID=45464052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000715 WO2012053006A2 (en) 2010-10-18 2011-10-17 Improved oral fast dissolving films comprising combination of polymers and method of preparation thereof

Country Status (1)

Country Link
WO (1) WO2012053006A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102860997A (en) * 2012-09-28 2013-01-09 天津市聚星康华医药科技有限公司 Ondansetron oral cavity instant membrane capable of sheltering taste and preparation method thereof

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012083269A1 (en) 2010-12-16 2012-06-21 Cynapsus Therapeutics, Inc. Sublingual films
WO2014027975A2 (en) * 2012-08-17 2014-02-20 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Novel orally administered pharmaceutical formulations
WO2014042416A1 (en) * 2012-09-13 2014-03-20 주식회사 씨티씨바이오 Oral composition containing dapoxetin-free base
FR2997402B1 (en) * 2012-10-30 2016-02-26 Oniris WATER-SOLUBLE FILMS FOR PACKAGING SOLID COMPOSITIONS AND METHOD OF MANUFACTURE
FR2999086B1 (en) * 2012-12-10 2015-04-10 Ethypharm Sa ORAL AND / OR ORAL COMPOSITION IN FINE FILM FORM OF A LOW SOLUBLE ACTIVE INGREDIENT, PROCESS FOR PREPARING THE SAME AND USE THEREOF
US11116769B2 (en) 2013-04-11 2021-09-14 Ctc Bio, Inc. Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer
KR102223105B1 (en) * 2013-04-11 2021-03-04 주식회사 씨티씨바이오 Film formulation containing tadalafil free base comprising polyethylene glycol based polymer and/or vinylpyrrolidone base polymer as dispersing agents
US20160303038A1 (en) * 2013-11-21 2016-10-20 Pawar Harshal Ashok Oral films
RU2666212C2 (en) * 2013-12-23 2018-09-06 Колгейт-Палмолив Компани Film compositions for oral use
EP3111929B1 (en) * 2014-06-24 2018-08-29 Wooshin Labottach Co., Ltd. Oral disintegrating film formulation containing tadalafil and preparation method therefor
EP3160589B1 (en) 2014-06-24 2023-10-25 TAHO Pharmaceuticals Ltd. Fast acting orally disintegrating film
KR101538985B1 (en) 2014-09-02 2015-07-24 주식회사 서울제약 Tadalafil Orally Disintegrating Film and Precess For Producing thereof
WO2015001541A2 (en) 2014-09-25 2015-01-08 Shilpa Medicare Limited Pharmaceutical film composition
CA2969466A1 (en) * 2014-12-09 2016-06-16 Monosolrx Llc Linear polysaccharide based film products
CA3019769C (en) * 2015-04-21 2021-10-12 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
IL247161A0 (en) * 2016-08-08 2016-12-29 Rubin Yoram Adhesive films for quick dissolution in managing oral conditions
US11154585B2 (en) * 2017-01-18 2021-10-26 Pharmathen S.A. Orodispersible film composition comprising enalapril for the treatment of hypertension in a pediatric population
DE102017107468B4 (en) 2017-04-06 2019-02-21 Lts Lohmann Therapie-Systeme Ag PROCESS FOR PREPARING AN IN PARTICULAR ORAL, ACTIVE LAMINATE AND ACTIVE LAMINATE, IN PARTICULAR ORAL ACTIVE LAMINATE
US10973760B1 (en) 2020-07-21 2021-04-13 King Abdulaziz University Instantly dissolving buccal films
CN114432272B (en) * 2020-11-02 2024-05-28 上海现代药物制剂工程研究中心有限公司 Orosity membrane, racecadotril orosity membrane agent and preparation method thereof
WO2022192476A1 (en) 2021-03-09 2022-09-15 Aquestive Therapeutics, Inc. Dosage forms having equivalent biocomparable profiles
WO2023036581A1 (en) * 2021-09-13 2023-03-16 Nutrition & Biosciences Usa 1, Llc A film-forming composition comprising pectin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784390A (en) 1971-07-23 1974-01-08 Hayashibara Biochem Lab Shaped bodies of pullulan and their use
JPS60219238A (en) 1984-04-14 1985-11-01 Hayashibara Biochem Lab Inc Formed product containing slowly disintegrating pullulan and its production
JP3232488B2 (en) 1992-08-20 2001-11-26 株式会社林原生物化学研究所 High content of pullulan, its production method and use
US5411945A (en) 1992-08-29 1995-05-02 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pullulan binder and its uses
ITMI20022343A1 (en) 2002-11-05 2004-05-06 Biofarm Srl FAST DISSOLUTION FILM IN WATER, CONTAINING COSMETIC, AROMATIC, PHARMACEUTICAL OR FOOD SYSTEMS.
US8999372B2 (en) * 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
ITMI20032087A1 (en) 2003-10-27 2005-04-28 Pharmafilm S R L SELF-SUPPORTING FILMS FOR PHARMACEUTICAL AND FOOD USE.
JP2009507854A (en) * 2005-09-09 2009-02-26 モノソル アールエックス リミテッド ライアビリティ カンパニー Uniform film for fast-dissolving formulations incorporating anti-blocking agents
JP5784878B2 (en) * 2007-03-07 2015-09-24 ノバルティス アーゲー Orally administrable film
WO2009043588A2 (en) * 2007-10-02 2009-04-09 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Ph regulating antibacterial films for the oral or vaginal cavity
KR100905027B1 (en) * 2007-10-03 2009-06-30 (주)씨엘팜 Edible Film
MX2010004265A (en) * 2007-10-19 2010-07-28 Innozen Inc Composition for administering an active ingredient and method for making and using the same.
US20090162516A1 (en) 2007-12-21 2009-06-25 Brown Solomon E Edible, water-soluble film

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102860997A (en) * 2012-09-28 2013-01-09 天津市聚星康华医药科技有限公司 Ondansetron oral cavity instant membrane capable of sheltering taste and preparation method thereof

Also Published As

Publication number Publication date
WO2012053006A3 (en) 2012-08-02
WO2012053006A2 (en) 2012-04-26

Similar Documents

Publication Publication Date Title
WO2012053006A8 (en) Improved oral fast dissolving films comprising combination of polymers and method of preparation thereof
Zayed et al. In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films
WO2007084460A3 (en) Pharmaceutical compositions with enhanced stability
EP3295935A3 (en) Crystallization method and bioavailability
WO2008100375A3 (en) Polymer-based films and drug delivery systems made therefrom
WO2010125475A3 (en) Sustained release formulations comprising gnrh analogues
NZ587897A (en) Drug delivery systems comprising weakly basic drugs and organic acids
WO2010005732A3 (en) Composition and method of preparation of release systems for constant (zero-order) release of active agents
BR112012027590A2 (en) blood coagulation factor viii conjugate
Wang et al. Self-assembly of zein-based microcarrier system for colon-targeted oral drug delivery
EP2444073A3 (en) Methods of forming self-supporting films for delivery of therapeutics agents
WO2011067667A3 (en) Fexofenadine microcapsules and compositions containing them
WO2008141111A3 (en) Polymers conjugated with platinum drugs
WO2017141204A3 (en) Biguanide grafted / modified biopolymers as drug delivery vehicles
MX2022003939A (en) Pharmaceutical composition with improved stability.
AU2014251532A1 (en) Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer
CY1115394T1 (en) MEDICINAL PRODUCTION OF IBURROFEN FOR INJECTION
WO2009028598A1 (en) Sustained release preparation and process for production thereof
WO2012092486A3 (en) Modified release benzimidazole formulations
WO2012172433A3 (en) A sustained -release composition containing a melanocortin receptor ligand as the active ingredient
JP6346623B2 (en) Chewable composition for oral administration and method for producing the same
WO2012055947A3 (en) Preparation of orodispersible films
WO2011117391A3 (en) Novel composition for treatment of essential thrombocythemia
WO2008103264A3 (en) Polymer particles
WO2009117188A3 (en) Stabilization of macromolecular membranes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11805637

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct app. not ent. europ. phase

Ref document number: 11805637

Country of ref document: EP

Kind code of ref document: A2