WO2012051601A3 - Heteroarylthio compounds - Google Patents

Heteroarylthio compounds Download PDF

Info

Publication number
WO2012051601A3
WO2012051601A3 PCT/US2011/056479 US2011056479W WO2012051601A3 WO 2012051601 A3 WO2012051601 A3 WO 2012051601A3 US 2011056479 W US2011056479 W US 2011056479W WO 2012051601 A3 WO2012051601 A3 WO 2012051601A3
Authority
WO
WIPO (PCT)
Prior art keywords
heteroarylthio
compounds
treatment
covalently linked
neurological conditions
Prior art date
Application number
PCT/US2011/056479
Other languages
French (fr)
Other versions
WO2012051601A2 (en
Inventor
David Brian Fick
David Reed Helton
Original Assignee
Epiomed Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epiomed Therapeutics, Inc. filed Critical Epiomed Therapeutics, Inc.
Priority to US13/879,142 priority Critical patent/US20130289047A1/en
Publication of WO2012051601A2 publication Critical patent/WO2012051601A2/en
Publication of WO2012051601A3 publication Critical patent/WO2012051601A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Heteroarylthio compounds covalently linked to an arylpiperazine moiety for the treatment of neurological conditions.
PCT/US2011/056479 2010-10-14 2011-10-14 Heteroarylthio compounds WO2012051601A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/879,142 US20130289047A1 (en) 2010-10-14 2011-10-14 Heteroarylthio derivatives and analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39334910P 2010-10-14 2010-10-14
US61/393,349 2010-10-14

Publications (2)

Publication Number Publication Date
WO2012051601A2 WO2012051601A2 (en) 2012-04-19
WO2012051601A3 true WO2012051601A3 (en) 2012-06-21

Family

ID=45939022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/056479 WO2012051601A2 (en) 2010-10-14 2011-10-14 Heteroarylthio compounds

Country Status (2)

Country Link
US (1) US20130289047A1 (en)
WO (1) WO2012051601A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103626748B (en) * 2013-12-10 2016-08-17 浙江工业大学 A kind of diazoles compound containing pyridine and preparation and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0977765A (en) * 1995-09-18 1997-03-25 Roussel Morishita Kk 2-((1h-benzimidazol-2-yl)thiomethyl)-4-substituted amino-5-pyrimidinecarboxylic acid ester derivative
US20070066542A1 (en) * 2003-05-27 2007-03-22 Societe De Conseils De Recherches Et D'application Scientifiques (S.C.R.A.S.) Novel imidazole derivatives, their preparation and their use as medicaments
US20090069340A1 (en) * 2004-12-27 2009-03-12 Astrazeneca Ab Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425146A1 (en) * 1994-07-15 1996-01-18 Basf Ag Use of heterocyclic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0977765A (en) * 1995-09-18 1997-03-25 Roussel Morishita Kk 2-((1h-benzimidazol-2-yl)thiomethyl)-4-substituted amino-5-pyrimidinecarboxylic acid ester derivative
US20070066542A1 (en) * 2003-05-27 2007-03-22 Societe De Conseils De Recherches Et D'application Scientifiques (S.C.R.A.S.) Novel imidazole derivatives, their preparation and their use as medicaments
US20090069340A1 (en) * 2004-12-27 2009-03-12 Astrazeneca Ab Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders

Also Published As

Publication number Publication date
WO2012051601A2 (en) 2012-04-19
US20130289047A1 (en) 2013-10-31

Similar Documents

Publication Publication Date Title
HRP20130357T1 (en) Novel compounds useful for the treatment of degenerative and inflammatory diseases.
PL2630108T3 (en) Process for the preparation of 2,3,3,3 tetrafluoropropene
WO2011140517A9 (en) Methods for treating diseases of the lung
IL230635A (en) 1,2,3,4-tetrahydroquinoline derivative useful for the treatment of diabetes
WO2012061607A3 (en) Compositions comprising functionalized carbon-based nanostructures and related methods
WO2011159945A9 (en) Methods for treating neurological conditions
WO2011069063A3 (en) Multicyclic compounds and methods of use thereof
AU2012213775A8 (en) 7-azaindole derivatives
WO2012025944A3 (en) Sitagliptin, salts and polymorphs thereof
WO2010150211A3 (en) Use of derivatives of indoles for the treatment of cancer
WO2011088027A8 (en) Compounds and methods
WO2012071414A3 (en) Quinoxaline compounds and uses thereof
WO2011047091A9 (en) Methods for treating traumatic brain injury
WO2012104823A3 (en) Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
WO2014086453A8 (en) Azaheterobicyclic compounds
IL220846A0 (en) Process for the preparation of nebivolol
IL226153A (en) Process for the preparation of nebivolol
WO2012064743A3 (en) Methods for improving heart function
EP3081097B8 (en) Composition for the treatment of infertility
WO2012054782A3 (en) Fluoroalkoxylation of organic compounds
WO2012068332A9 (en) Methods for treating early stage or mild neurological disorders
WO2011000945A3 (en) Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns
WO2012051601A3 (en) Heteroarylthio compounds
EA201390620A1 (en) OXAZOLO [5,4-b] PIRIDIN-5-ILY COMPOUNDS
WO2012051251A8 (en) Methods of treating giardiasis

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11833536

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13879142

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 11833536

Country of ref document: EP

Kind code of ref document: A2