WO2012044939A3 - Method of preparing a dry powder from a water bacteria extract-concentrate - Google Patents

Method of preparing a dry powder from a water bacteria extract-concentrate Download PDF

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Publication number
WO2012044939A3
WO2012044939A3 PCT/US2011/054238 US2011054238W WO2012044939A3 WO 2012044939 A3 WO2012044939 A3 WO 2012044939A3 US 2011054238 W US2011054238 W US 2011054238W WO 2012044939 A3 WO2012044939 A3 WO 2012044939A3
Authority
WO
WIPO (PCT)
Prior art keywords
homogenate
concentrated
produce
dry powder
solvent
Prior art date
Application number
PCT/US2011/054238
Other languages
French (fr)
Other versions
WO2012044939A2 (en
Inventor
Emil Golub
Original Assignee
Emil Golub
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emil Golub filed Critical Emil Golub
Priority to BR112013007641A priority Critical patent/BR112013007641A2/en
Priority to JP2013531915A priority patent/JP2013540125A/en
Priority to KR1020137010763A priority patent/KR20130137637A/en
Priority to AU2011308616A priority patent/AU2011308616A1/en
Priority to CA2813253A priority patent/CA2813253A1/en
Priority to EP11829971.8A priority patent/EP2621478A4/en
Priority to EA201370083A priority patent/EA201370083A1/en
Priority to CN2011800512589A priority patent/CN103179958A/en
Publication of WO2012044939A2 publication Critical patent/WO2012044939A2/en
Publication of WO2012044939A3 publication Critical patent/WO2012044939A3/en
Priority to IL225505A priority patent/IL225505A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

A method to produce a dry powder cancer treatment substance from a cultured bacterial growth in water includes the steps of culturing a desired bacterial growth in a solvent to produce a bacterial mass, which is then homogenized to a homogenate. Solid particulates are then removed from the homogenate by passing the homogenate through a first filter. The filtered homogenate is collected and filtered through a second filter to remove high molecular weight chemicals from the solution. The homogenate is concentrated by separating the solvent from the homogenate yielding an extract to increase the solids content and produce a concentrated homogenate. The concentrated homogenate is dried to evaporate remaining solvent and transform the concentrated homogenate to a powder. The powder is encapsulated in individual capsules, which in turn are packaged in blister packs.
PCT/US2011/054238 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate WO2012044939A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BR112013007641A BR112013007641A2 (en) 2010-09-30 2011-09-30 method of producing a dry powder substance for the treatment of cancer from a bacterial proliferation grown in water and method of treating cancer in a patient
JP2013531915A JP2013540125A (en) 2010-09-30 2011-09-30 Method for the preparation of dry powder from aquatic bacterial extract-concentrate
KR1020137010763A KR20130137637A (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate
AU2011308616A AU2011308616A1 (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate
CA2813253A CA2813253A1 (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate
EP11829971.8A EP2621478A4 (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate
EA201370083A EA201370083A1 (en) 2010-09-30 2011-09-30 METHOD OF OBTAINING DRY POWDER FROM BACTERIAL SUSPENSION CONCENTRATE (WATER EXTRACT)
CN2011800512589A CN103179958A (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate
IL225505A IL225505A0 (en) 2010-09-30 2013-04-02 Method of preparing a dry powder from a water bacteria extract-concentrate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38830410P 2010-09-30 2010-09-30
US61/388,304 2010-09-30

Publications (2)

Publication Number Publication Date
WO2012044939A2 WO2012044939A2 (en) 2012-04-05
WO2012044939A3 true WO2012044939A3 (en) 2012-06-14

Family

ID=45893766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/054238 WO2012044939A2 (en) 2010-09-30 2011-09-30 Method of preparing a dry powder from a water bacteria extract-concentrate

Country Status (10)

Country Link
EP (1) EP2621478A4 (en)
JP (1) JP2013540125A (en)
KR (1) KR20130137637A (en)
CN (1) CN103179958A (en)
AU (1) AU2011308616A1 (en)
BR (1) BR112013007641A2 (en)
CA (1) CA2813253A1 (en)
EA (1) EA201370083A1 (en)
IL (1) IL225505A0 (en)
WO (1) WO2012044939A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102227125B1 (en) 2019-05-15 2021-03-11 숙명여자대학교산학협력단 Method for storing bacteria and dry power produces by the same method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374827A (en) * 1979-08-30 1983-02-22 Yamanouchi Pharmaceutical Co., Ltd. Water soluble extract from nonpathogenic aerobic corynebacteria
EP0416892A1 (en) * 1989-09-05 1991-03-13 Ajinomoto Co., Inc. Agents for the prevention and treatment of diarrhoea
EP0564121A2 (en) * 1992-03-29 1993-10-06 Era-Masis Ltd., Formulation for the treatment of cancer comprising a bacterial extract
US20060233808A1 (en) * 2003-04-04 2006-10-19 David Deperthes Peptabody for cancer treatment
US20070009490A1 (en) * 2003-10-02 2007-01-11 Conte Anthony E Dried biotherapeutic composition, uses, and device and methods for administration thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58150595A (en) * 1982-03-03 1983-09-07 Banyu Pharmaceut Co Ltd Antitumor antibiotic ail
JPS61280437A (en) * 1985-05-29 1986-12-11 Suntory Ltd Production of novel polypeptide having antitumor activity
GB0003620D0 (en) * 2000-02-16 2000-04-05 Norferm Da Method
WO2010065520A1 (en) * 2008-12-01 2010-06-10 Alexion Pharmaceuticals, Inc. Methods for preparing aerolysin polypeptides or conjugates thereof
CN101824406B (en) * 2009-03-06 2012-05-30 中国医学科学院放射医学研究所 Recombinant beta-lactamase-RGD-fusion protein and application thereof in medicine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374827A (en) * 1979-08-30 1983-02-22 Yamanouchi Pharmaceutical Co., Ltd. Water soluble extract from nonpathogenic aerobic corynebacteria
EP0416892A1 (en) * 1989-09-05 1991-03-13 Ajinomoto Co., Inc. Agents for the prevention and treatment of diarrhoea
EP0564121A2 (en) * 1992-03-29 1993-10-06 Era-Masis Ltd., Formulation for the treatment of cancer comprising a bacterial extract
US20060233808A1 (en) * 2003-04-04 2006-10-19 David Deperthes Peptabody for cancer treatment
US20070009490A1 (en) * 2003-10-02 2007-01-11 Conte Anthony E Dried biotherapeutic composition, uses, and device and methods for administration thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D. W. HOSKIN ET AL.: "Studies on anticancer activities of antimicrobial peptides", BIOCHIMICA BIOPHYSICA ACTA, vol. 1778, no. 2, February 2008 (2008-02-01), pages 357 - 375, XP022428150 *

Also Published As

Publication number Publication date
EP2621478A2 (en) 2013-08-07
IL225505A0 (en) 2013-06-27
KR20130137637A (en) 2013-12-17
JP2013540125A (en) 2013-10-31
WO2012044939A2 (en) 2012-04-05
AU2011308616A1 (en) 2013-04-18
EA201370083A1 (en) 2014-01-30
CA2813253A1 (en) 2012-04-05
EP2621478A4 (en) 2014-08-13
BR112013007641A2 (en) 2019-09-24
CN103179958A (en) 2013-06-26

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