WO2012044567A3 - Imidazole derivatives - Google Patents

Imidazole derivatives Download PDF

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Publication number
WO2012044567A3
WO2012044567A3 PCT/US2011/053213 US2011053213W WO2012044567A3 WO 2012044567 A3 WO2012044567 A3 WO 2012044567A3 US 2011053213 W US2011053213 W US 2011053213W WO 2012044567 A3 WO2012044567 A3 WO 2012044567A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazole derivatives
compounds
formula
hyperlipidemia
obesity
Prior art date
Application number
PCT/US2011/053213
Other languages
French (fr)
Other versions
WO2012044567A2 (en
Inventor
Jian Liu
James M. Balkovec
Arto D. Krikorian
Deodial Guiadeen
Ginger Xu-Qiang YANG
Tianying Jian
Zhicai Wu
Yang Yu
Ravi P. Nargund
Petr Vachal
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of WO2012044567A2 publication Critical patent/WO2012044567A2/en
Publication of WO2012044567A3 publication Critical patent/WO2012044567A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Described herein are compounds of Formula (I). The compounds of Formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
PCT/US2011/053213 2010-09-30 2011-09-26 Imidazole derivatives WO2012044567A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38809410P 2010-09-30 2010-09-30
US61/388,094 2010-09-30

Publications (2)

Publication Number Publication Date
WO2012044567A2 WO2012044567A2 (en) 2012-04-05
WO2012044567A3 true WO2012044567A3 (en) 2014-03-20

Family

ID=45893733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/053213 WO2012044567A2 (en) 2010-09-30 2011-09-26 Imidazole derivatives

Country Status (1)

Country Link
WO (1) WO2012044567A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2538964C1 (en) 2010-12-17 2015-01-10 Мицубиси Танабе Фарма Корпорейшн Compound with successive aricyclic structure, possessing activity of inhibiting acycloenzyme a diacylglycerolacyltransferase (dgat1)
AU2012264651A1 (en) * 2011-06-02 2013-12-12 Intervet International B.V. Imidazole derivatives
EP2862856B1 (en) * 2012-06-15 2018-08-01 Mitsubishi Tanabe Pharma Corporation Imidazole and triazole compounds as dgat-1 inhibitors
PE20150354A1 (en) * 2012-07-10 2015-03-21 Bayer Pharma AG METHODS FOR PREPARING SUBSTITUTE TRIAZOLOPYRIDINES
KR102227271B1 (en) 2013-04-15 2021-03-12 에프엠씨 코포레이션 Fungicidal amides
CN103214456B (en) * 2013-04-20 2015-02-25 郎恒元 Benzimidazole compound with antitumour activity as well as preparation method and application thereof
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
EP4364798A2 (en) 2018-10-05 2024-05-08 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090186891A1 (en) * 2007-09-28 2009-07-23 Kwak Young-Shin Organic compounds
US7795283B2 (en) * 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7795283B2 (en) * 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors
US20090186891A1 (en) * 2007-09-28 2009-07-23 Kwak Young-Shin Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LABUTE ET AL.: "A Probabilistic Approach to High Throughput Drug Discovery", COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 5, 2002, pages 135 - 145, XP008081986 *

Also Published As

Publication number Publication date
WO2012044567A2 (en) 2012-04-05

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