WO2012042467A3 - A magnetic hybrid hydrogel - Google Patents

A magnetic hybrid hydrogel Download PDF

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Publication number
WO2012042467A3
WO2012042467A3 PCT/IB2011/054240 IB2011054240W WO2012042467A3 WO 2012042467 A3 WO2012042467 A3 WO 2012042467A3 IB 2011054240 W IB2011054240 W IB 2011054240W WO 2012042467 A3 WO2012042467 A3 WO 2012042467A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
magnetic
acid
hydrogel
combinations
Prior art date
Application number
PCT/IB2011/054240
Other languages
French (fr)
Other versions
WO2012042467A2 (en
Inventor
Rolando Barbucci
Roberto Giardino
Original Assignee
Istituto Ortopedico Rizzoli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Ortopedico Rizzoli filed Critical Istituto Ortopedico Rizzoli
Publication of WO2012042467A2 publication Critical patent/WO2012042467A2/en
Publication of WO2012042467A3 publication Critical patent/WO2012042467A3/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a magnetic hybrid hydrogel comprising a biocompatible, bioreabsorbable polymer crosslinked with magnetic particles which act as crosslinking agents. The polymer can be a polysaccharide chosen from among carboxymethyl cellulose, hyaluronic acid, chitin, alginic acid, alginates, chitosan or combinations thereof; or else a synthetic polymer chosen from among polyacrylic acid, polylactic acid, polyvinylamine or combinations thereof. The magnetic nanoparticles can be nanoparticles of Fe2C>3, Fe304, Fe204 or else mixed nanoparticles of Fe and Co, Mn or Zn, preferably functionalized with -NH2, - COOH,-OH,-SH groups. The hydrogel is used in oncological medicine for the targeted administration and controlled release of a drug, or else in regenerative medicine for applications of cells or other factors for the purpose of regenerating or repairing a tissue or organ.
PCT/IB2011/054240 2010-09-27 2011-09-27 A magnetic hybrid hydrogel WO2012042467A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001752A ITMI20101752A1 (en) 2010-09-27 2010-09-27 HYDROGEL MAGNETIC HYBRID
ITMI2010A001752 2010-09-27

Publications (2)

Publication Number Publication Date
WO2012042467A2 WO2012042467A2 (en) 2012-04-05
WO2012042467A3 true WO2012042467A3 (en) 2012-07-12

Family

ID=43706452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/054240 WO2012042467A2 (en) 2010-09-27 2011-09-27 A magnetic hybrid hydrogel

Country Status (2)

Country Link
IT (1) ITMI20101752A1 (en)
WO (1) WO2012042467A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015148512A1 (en) 2014-03-24 2015-10-01 Qt Holdings Corp Shaped articles including hydrogels and methods of manufacture and use thereof
US9790467B2 (en) * 2015-09-22 2017-10-17 Qt Holdings Corp Methods and compositions for activation or expansion of T lymphocytes
KR20190138646A (en) * 2017-03-20 2019-12-13 큐티 홀딩스 코포레이션 Methods and Compositions for the Regulation of Immune Cells
CN108992703A (en) * 2018-08-17 2018-12-14 佛山市森昂生物科技有限公司 A kind of preparation method of highly-breathable medical gel material
CN110384655A (en) * 2019-08-30 2019-10-29 浙江理工大学 A kind of preparation method of high-biocompatibility pharmaceutical carrier hydrogel
CN113416319B (en) * 2021-05-25 2022-07-12 丽水学院 Ultraviolet light blocking type hydrogel containing immobilized nanoparticles and preparation method thereof
CN113559909A (en) * 2021-07-27 2021-10-29 陕西科技大学 Magnetic LDO/CN composite catalyst and preparation method and application thereof
CN113501976B (en) * 2021-08-11 2022-06-03 电子科技大学 Preparation method of electromagnetic shielding self-repairing skin-friendly hydrogel
CN113730639B (en) * 2021-09-15 2022-05-06 上海大学 Magnetic dressing and preparation method and application thereof
KR20230097904A (en) * 2021-12-24 2023-07-03 서울대학교산학협력단 Nanocomposite for drug delivery
CN116809032B (en) * 2023-07-03 2024-06-04 中国热带农业科学院南亚热带作物研究所 Sulfhydryl modified chitosan porous microsphere and preparation method and application thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARAKAT NAHLA S: "Magnetically modulated nanosystems: a unique drug-delivery platform", NANOMEDICINE,, vol. 4, no. 7, 1 October 2009 (2009-10-01), pages 799 - 812, XP009145958 *
DANIEL-DA-SILVA ANA L ET AL: "Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan.", NANOTECHNOLOGY 2 SEP 2009 LNKD- PUBMED:19671980, vol. 20, no. 35, 2 September 2009 (2009-09-02), pages 355602, XP020164712, ISSN: 1361-6528 *
FUHRER ROLAND ET AL: "Crosslinking metal nanoparticles into the polymer backbone of hydrogels enables preparation of soft, magnetic field-driven actuators with muscle-like flexibility", SMALL, WILEY - VCH VERLAG GMBH & CO. KGAA, DE, vol. 5, no. 3, 1 March 2009 (2009-03-01), pages 383 - 388, XP009145959, ISSN: 1613-6810 *
GUPTA A K ET AL: "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 18, 1 January 2005 (2005-01-01), pages 3995 - 4021, XP002542497, ISSN: 0142-9612, [retrieved on 20041210], DOI: DOI:10.1016/J.BIOMATERIALS.2004.10.012 *
LAPOINTE J ET AL: "Thermoresponsive hydrogel with embedded magnetic nanoparticles for the implementation of shrinkable medical microrobots and for targeting and drug delivery applications", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 2009. EMBC 2009. ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, PISCATAWAY, NJ, USA, 3 September 2009 (2009-09-03), pages 4246 - 4249, XP031638186, ISBN: 978-1-4244-3296-7 *
MEENACH SAMANTHA A ET AL: "Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility, and Toxicity Analysis", SAFETY OF NANOPARTICLES: FROM MANUFACTURING TO MEDICAL APPLICATIONS SPRINGER, 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SERIES : NANOSTRUCTURE SCIENCE AND TECHNOLOGY, 2009, pages 131 - 157, XP009145993 *

Also Published As

Publication number Publication date
ITMI20101752A1 (en) 2012-03-28
WO2012042467A2 (en) 2012-04-05

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