WO2012039559A3 - Tofi variant proteins and method for producing the same - Google Patents

Tofi variant proteins and method for producing the same Download PDF

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Publication number
WO2012039559A3
WO2012039559A3 PCT/KR2011/006797 KR2011006797W WO2012039559A3 WO 2012039559 A3 WO2012039559 A3 WO 2012039559A3 KR 2011006797 W KR2011006797 W KR 2011006797W WO 2012039559 A3 WO2012039559 A3 WO 2012039559A3
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WO
WIPO (PCT)
Prior art keywords
tofi
variant
producing
same
variant proteins
Prior art date
Application number
PCT/KR2011/006797
Other languages
French (fr)
Other versions
WO2012039559A2 (en
Inventor
Sang Kee Rhee
Ji Woung Chung
Sang Heon Yu
Original Assignee
Snu R&Db Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snu R&Db Foundation filed Critical Snu R&Db Foundation
Publication of WO2012039559A2 publication Critical patent/WO2012039559A2/en
Publication of WO2012039559A3 publication Critical patent/WO2012039559A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention discloses a TofI variant. The TofI variant has the same amino acid sequence as that of SEQ ID NO: 1 encoding a wild-type TofI, with the exception that both the histidine (His) at position 91 and the proline (Pro) at position 92 are deleted. In addition, a nucleic acid coding for the TofI variant, a vector carrying the nucleic acid, and a transformant transformed with the vector are disclosed. Methods are also provided for crystallizing the TofI variant and for producing the TofI variant.
PCT/KR2011/006797 2010-09-20 2011-09-15 Tofi variant proteins and method for producing the same WO2012039559A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100092657A KR101197956B1 (en) 2010-09-20 2010-09-20 Modified TofI protein and method for producing the same
KR10-2010-0092657 2010-09-20

Publications (2)

Publication Number Publication Date
WO2012039559A2 WO2012039559A2 (en) 2012-03-29
WO2012039559A3 true WO2012039559A3 (en) 2012-06-28

Family

ID=45874238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/006797 WO2012039559A2 (en) 2010-09-20 2011-09-15 Tofi variant proteins and method for producing the same

Country Status (2)

Country Link
KR (1) KR101197956B1 (en)
WO (1) WO2012039559A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033549A1 (en) * 1999-09-03 2004-02-19 Greenberg E. Peter Quorum sensing signaling in bacteria
US20100137641A1 (en) * 2007-02-23 2010-06-03 Mizkan Group Corporation Gene involved in quorum-sensing system of acetic acid bacterium, acetic acid bacterium bred by modification of the gene and method for production of vinegar by using the acetic acid bacterium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033549A1 (en) * 1999-09-03 2004-02-19 Greenberg E. Peter Quorum sensing signaling in bacteria
US20100137641A1 (en) * 2007-02-23 2010-06-03 Mizkan Group Corporation Gene involved in quorum-sensing system of acetic acid bacterium, acetic acid bacterium bred by modification of the gene and method for production of vinegar by using the acetic acid bacterium

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 31 May 2005 (2005-05-31), "AHL synthase [Burkholderia glumae BGR1]", accession no. AV52805 *
DEVESCOVI, G. ET AL.: "Involvement of a Quorum-Sensing-Regulated Lipase Secreted by a Clinical Isolate of Burkholderia glumae in Severe Disease Symptoms in Rice.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 73, no. 15, 2007, pages 5950 - 4958 *
WATSON, W. T. ET AL.: "Structural Basis and Specificity of Acyl-Homoserine Lactone Signal Production in Bacterial Quorum Sensing.", MOLECULAR CELL., vol. 9, 2002, pages 685 - 694, XP002991660, DOI: doi:10.1016/S1097-2765(02)00480-X *

Also Published As

Publication number Publication date
KR20120030289A (en) 2012-03-28
KR101197956B1 (en) 2012-11-05
WO2012039559A2 (en) 2012-03-29

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