WO2012032534A3 - Furanose derivatives and their applications in synthesis of statins - Google Patents
Furanose derivatives and their applications in synthesis of statins Download PDFInfo
- Publication number
- WO2012032534A3 WO2012032534A3 PCT/IN2011/000523 IN2011000523W WO2012032534A3 WO 2012032534 A3 WO2012032534 A3 WO 2012032534A3 IN 2011000523 W IN2011000523 W IN 2011000523W WO 2012032534 A3 WO2012032534 A3 WO 2012032534A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthesis
- statins
- applications
- furanose derivatives
- furanose
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/14—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
- C07D303/26—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The present invention relates to compounds of formula XXII and their synthesis from furanose derivatives as shown hereunder. Compounds of formula XXII are of use in the synthesis of statins.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1583DE2010 | 2010-09-06 | ||
IN1583/DEL/2010 | 2010-09-06 | ||
IN2641/DEL/2010 | 2010-11-03 | ||
IN2641DE2010 | 2010-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012032534A2 WO2012032534A2 (en) | 2012-03-15 |
WO2012032534A3 true WO2012032534A3 (en) | 2012-08-02 |
Family
ID=44910033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2011/000523 WO2012032534A2 (en) | 2010-09-06 | 2011-08-08 | Furanose derivatives and their applications in synthesis of statins |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012032534A2 (en) |
-
2011
- 2011-08-08 WO PCT/IN2011/000523 patent/WO2012032534A2/en active Application Filing
Non-Patent Citations (8)
Title |
---|
BECUCCI T ET AL: "3-deoxy-D-glycero-pentulose: a convenient starting material for the synthesis of 4-hydroxyprolinol", GAZZETTA CHIMICA ITALIANA, SOCIETA CHIMICA, ITALIANA, ROME; IT, vol. 127, no. 2, 1 January 1997 (1997-01-01), pages 73 - 78, XP008145363, ISSN: 0016-5603 * |
DANIEL SCHLAWE ET AL: "Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 13, 19 March 2004 (2004-03-19), pages 1731 - 1734, XP055012317, ISSN: 1433-7851, DOI: 10.1002/anie.200353132 * |
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1997, BECUCCI, TERESA; CAPOZZI, GIUSEPPE; MENICHETTI, STEFANO; NATIVI, CRISTINA; SALSINI, LIANA: "3-Deoxy-D-glycero-pentulose: a convenient starting material for the synthesis of 4-hydroxyprolinol", XP002663807, retrieved from STN Database accession no. 1997:459442 * |
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ATTWOOD, STEPHEN V.; BARRETT, ANTHONY G. M.: "A convenient procedure for the deoxygenation and homologation of D-ribose derivatives", XP002663809, retrieved from STN Database accession no. 1984:592304 * |
J ARIZA: "Stereoselective Synthesis of 4,5-Dihydroxy-D-erythro- and 4,5-Dihydroxy-D-threo-L-norvaline from D-Ribonolactone", TETRAHEDRON, vol. 49, no. 6, 5 February 1993 (1993-02-05), pages 1315 - 1326, XP055012374, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)85821-X * |
KAZUTOSHI MIYAZAWA ET AL: "A Convenient Synthesis of (2S,4R)-1-Acetoxy-2,4-O-Isopropylidene-1,2, 5-Pentanetriol by Using Lipase Catalyzed Regio- and Enantioselective Reactions", CHEMISTRY LETTERS, vol. 22, no. 9, 1 January 1993 (1993-01-01), CHEMICAL SOCIETY OF JAPAN, JP, pages 1529 - 1530, XP008145352, ISSN: 0366-7022, DOI: 10.1246/CL.1993.1529 * |
LIPSHUTZ B H ET AL: "More highly mixed, higher order cyanocuprates ''RT(2-thienyl)Cu(CN)Li2''. Efficient reagents which promote selective ligand transfer", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH, vol. 285, no. 1-3, 16 April 1985 (1985-04-16), pages 437 - 447, XP026619807, ISSN: 0022-328X, [retrieved on 19850416], DOI: 10.1016/0022-328X(85)87388-5 * |
STEPHEN V ATTWOOD AND ANTHONY G M BARRETT: "A convenient procedure for the deoxygenation and homologation of D-ribose derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1984 (1984-01-01), pages 1315 - 1322, XP008145385, ISSN: 0300-922X, DOI: 10.1039/P19840001315 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012032534A2 (en) | 2012-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JOP20180102B1 (en) | Pharmaceutical composition | |
IL247804B (en) | Heterocyclic modulators of lipid synthesis, compositions comprising the same and uses thereof | |
NZ603151A (en) | N3-substituted-n1-sulfonyl-5-fluoropyrimidinone derivatives | |
MX2013002417A (en) | Pesticidal compositions. | |
EA201270257A1 (en) | DERIVATIVES N1-SULFONIL-5-FTORPYRIMIDINONA | |
IN2012DN00736A (en) | ||
WO2011077043A3 (en) | Phenol derivatives and pharmaceutical or cosmetic use thereof | |
WO2011153157A3 (en) | Benzoquinolone inhibitors of vmat2 | |
IL224288A (en) | Derivatives of substituted pyrazolamide, pharmaceutical compositions comprising the same and uses thereof | |
MX2012007161A (en) | Phenol derivatives and pharmaceutical or cosmetic use thereof. | |
WO2011098582A3 (en) | Novel crystalline forms of ivabradine hydrochloride | |
MX2011014019A (en) | Diazahomoadamantane derivatives and methods of use thereof. | |
UA106889C2 (en) | N1-ACYL-5-FLORPYRIMIDINONE DERIVATIVES | |
HK1133642A1 (en) | Azaadamantane ester and carbamate derivatives and methods of use thereof | |
EA201101675A1 (en) | SPYROEPOXIDES AS INTERMEDIATE PRODUCTS OF SYNTHESIS | |
WO2012054695A8 (en) | Antimicrobial amphiphiles and methods for their use | |
EA201290243A1 (en) | Quinazoline compounds | |
WO2012154879A3 (en) | Autophagy inhibitors | |
WO2014172363A3 (en) | Combretastatin analogs | |
EP3456837A3 (en) | Decorin compositions and use thereof | |
WO2014014515A3 (en) | Melanogenesis inhibition-methods and compositions thereof | |
WO2012032534A3 (en) | Furanose derivatives and their applications in synthesis of statins | |
TN2012000381A1 (en) | 2-aldoximino-5-fluoropyrimidine derivatives | |
WO2012004073A3 (en) | Use of beta-isophorone as solvent | |
MX2012007097A (en) | Phenol derivatives and the pharmaceutical or cosmetic use thereof. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11770880 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 11770880 Country of ref document: EP Kind code of ref document: A2 |