WO2012031752A8 - Tuberculosis mutants - Google Patents

Tuberculosis mutants Download PDF

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Publication number
WO2012031752A8
WO2012031752A8 PCT/EP2011/004504 EP2011004504W WO2012031752A8 WO 2012031752 A8 WO2012031752 A8 WO 2012031752A8 EP 2011004504 W EP2011004504 W EP 2011004504W WO 2012031752 A8 WO2012031752 A8 WO 2012031752A8
Authority
WO
WIPO (PCT)
Prior art keywords
relates
present
tuberculosis
vaccine
further aspect
Prior art date
Application number
PCT/EP2011/004504
Other languages
French (fr)
Other versions
WO2012031752A2 (en
WO2012031752A3 (en
Inventor
Priscille Brodin
Sejin Park
Fanny Anne Ewann
Isabelle Peguillet
Denis Fenistein
Thierry Christophe
Auguste Genovesio
Olivier Neyrolles
Florence Levillain
Brigitte Gicquel
Yannick Pocquet
Original Assignee
Institut Pasteur Korea
Centre National De La Recherche Scientifique (Cnrs)
Institut National De La Sante Et De La Recherche Medicale (Inserm) (Epst)
Universite Toulouse Iii - Paul Sabatier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur Korea, Centre National De La Recherche Scientifique (Cnrs), Institut National De La Sante Et De La Recherche Medicale (Inserm) (Epst), Universite Toulouse Iii - Paul Sabatier filed Critical Institut Pasteur Korea
Publication of WO2012031752A2 publication Critical patent/WO2012031752A2/en
Publication of WO2012031752A8 publication Critical patent/WO2012031752A8/en
Publication of WO2012031752A3 publication Critical patent/WO2012031752A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to mycobacterial genes involved in phagosome maturation arrest. In another aspect, the present invention relates to assays for identifying virulence genes in intracellular pathogens and for identifying agents against intracellular pathogens. In a further aspect, the present invention relates to Mycobacterium tuberculosis mutants and their use as a vaccine. In a further aspect, the present invention relates to a vaccine for tuberculosis and methods of its production.
PCT/EP2011/004504 2010-09-07 2011-09-07 Tuberculosis mutants WO2012031752A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38056710P 2010-09-07 2010-09-07
US61/380,567 2010-09-07

Publications (3)

Publication Number Publication Date
WO2012031752A2 WO2012031752A2 (en) 2012-03-15
WO2012031752A8 true WO2012031752A8 (en) 2012-06-07
WO2012031752A3 WO2012031752A3 (en) 2012-07-26

Family

ID=44677835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/004504 WO2012031752A2 (en) 2010-09-07 2011-09-07 Tuberculosis mutants

Country Status (1)

Country Link
WO (1) WO2012031752A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3092000A1 (en) 2014-01-09 2016-11-16 Transgene SA Fusion of heterooligomeric mycobacterial antigens
WO2016013873A1 (en) * 2014-07-23 2016-01-28 연세대학교 산학협력단 Vaccine composition for preventing tuberculosis containing rv3112, mtbk 20620 or mtbk 24820 protein
KR101564323B1 (en) * 2014-07-23 2015-10-29 연세대학교 산학협력단 Vaccine composition for tuberculosis containing Rv3112 protein
CN104388575B (en) * 2014-12-10 2017-05-10 扬州大学 Kit for identifying nucleic acid of mycobacterium pathogeny through multiple PCR (polymerase chain reaction)
CN106405107B (en) * 2016-08-31 2018-04-06 中国疾病预防控制中心传染病预防控制所 Antigen of mycobacterium tuberculosis albumen Rv2941 and its t cell epitope peptide application
RU2684314C2 (en) * 2017-06-30 2019-04-05 федеральное государственное бюджетное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии" Министерства здравоохранения Российской Федерации Method of identification of mycobacteria of tuberculosis of the beijing genotype b0 cluster in real time format
CN108165564B (en) * 2017-12-01 2021-06-08 北京蛋白质组研究中心 Mycobacterium tuberculosis H37Rv encoding gene and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6290966B1 (en) * 1999-07-09 2001-09-18 Albert Einstein College Of Medicine Of Yeshiva University Dim mutants of mycobacteria and use thereof

Also Published As

Publication number Publication date
WO2012031752A2 (en) 2012-03-15
WO2012031752A3 (en) 2012-07-26

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