WO2012025460A1 - Oxadiazolinone derivatives and use thereof in pest control - Google Patents
Oxadiazolinone derivatives and use thereof in pest control Download PDFInfo
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- WO2012025460A1 WO2012025460A1 PCT/EP2011/064297 EP2011064297W WO2012025460A1 WO 2012025460 A1 WO2012025460 A1 WO 2012025460A1 EP 2011064297 W EP2011064297 W EP 2011064297W WO 2012025460 A1 WO2012025460 A1 WO 2012025460A1
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- 0 C[n](c(C(F)(F)F)c1)nc1C(O)=* Chemical compound C[n](c(C(F)(F)F)c1)nc1C(O)=* 0.000 description 3
- ALNXJJCINNCYQF-UHFFFAOYSA-N C[n](c(C(F)(F)F)c1)nc1C#N Chemical compound C[n](c(C(F)(F)F)c1)nc1C#N ALNXJJCINNCYQF-UHFFFAOYSA-N 0.000 description 2
- VGNXYYMYAASNIF-UHFFFAOYSA-N CN(C(C1)c2ccc[o]2)N(C)C1(C(C=C)(F)F)O Chemical compound CN(C(C1)c2ccc[o]2)N(C)C1(C(C=C)(F)F)O VGNXYYMYAASNIF-UHFFFAOYSA-N 0.000 description 1
- OWLPCALGCHDBCN-UHFFFAOYSA-N O=C(CC(c1ccc[o]1)=O)C(F)(F)F Chemical compound O=C(CC(c1ccc[o]1)=O)C(F)(F)F OWLPCALGCHDBCN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Definitions
- the present invention relates to a novel oxadiazolinone derivative and use thereof in pest control.
- Oxadiazolinone compounds are known to be useful as pest control agents.
- WO 2010/035899 discloses a compound in which an oxadiazolinone ring and an aromatic group such as a phenyl group are bonded at ortho and para positions, respectively, relative to nitrogen in a pyridine ring.
- WO 2009/066786 discloses a compound in which an oxadiazolinone ring and a group such as a haloalkyl group are bonded at ortho and para positions, respectively, relative to nitrogen in a pyridine ring.
- JP Patent Application Publication No. 2002-205991 discloses a compound in which an oxadiazolinone ring and a trifluoromethyl group are bonded at meta and para positions, respectively, relative to nitrogen in a pyridine ring.
- Patent Literatures 1 to 3 disclose oxadiazolinone compounds with various structures, as described above, there is still a great demand on oxadiazolinone derivatives with a novel structure having high activity.
- the object of the present invention is to provide an oxadiazolinone derivative that has a novel structure and is suitable for use in pest control.
- the present inventors have diligently studied to develop a novel compound that exhibits higher effect as an insecticide and has a broad spectrum thereas and have consequently accomplished the present invention this time by finding a novel oxadiazolinone derivative that is available for use in pest control.
- the present invention relates to an
- G represents a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms, and the heterocyclic ring may be substituted by R 3 , with the proviso that when G represents a pyridine ring substituted by R 3 and when the nitrogen atom in the pyridine ring is at an ortho position relative to the carbon atom bonded to the oxadiazolinone ring, the positions of the carbon atom bonded to R 1 and the carbon atom bonded to R 3 are each limited to any position selected from the ortho and meta positions relative to this nitrogen atom;
- R 3 represents hydrogen, halogen, nitro, cyano, C M2 alkyl, C M2 haloalkyi, C M2 alkoxy, Ci- 12 haloalkoxy, C M2 alkylsulfenyl, C M2 alkylsulfinyl, C M2 alkylsulfonyl, C M2 haloalkylsulfenyl, Ci- 12 haloalkylsulfinyl, C M2 haloalkylsulfonyl, hydroxy, mercapto or C 3 . 8 cycloalkyl;
- X represents an oxygen or sulfur atom
- R 1 represents C M2 haloalkyi, C M2 haloalkoxy, C M2 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_i 2 alkyl)amino, phenyl- Ci- 12 alkoxy, phenyl-Ci_i 2 alkylsulfenyl, phenyl-Ci_i 2 alkylsulfinyl, phenyl-Ci_i 2 alkylsulfonyl, phenyl-Ci-i 2 alkylamino, C M2 alkylsulfenyl, C M2 alkylsulfinyl, C M2 alkylsulfonyl, C M 2
- haloalkylsulfenyl C M2 haloalkylsulfinyl, C M2 haloalkylsulfonyl, C M2 alkylsulfinyl-Ci-i 2 alkyl, Ci. 12 alkylsulfonyl-Ci-12 alkyl, CM 2 haloalkylsulfenyl-Ci-i 2 alkyl, CM 2 haloalkylsulfinyl-Ci-i 2 alkyl, Ci.
- R 2 represents hydrogen, -CH 2 CN, C M2 alkyl, C M2 haloalkyi, C 3 . 8 cycloalkyl which may be optionally substituted by a substituent(s) selected from halogen, C M2 alkyl and C M 2 haloalkyi, benzyl which may be optionally substituted by a substituent selected from halogen, cyano, nitro, C M2 alkyl, C M2 haloalkyi and C M2 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
- R 21 represents hydrogen, C M2 alkyl, C M2 haloalkyi or C 3 . 8 cycloalkyl; R 22 and R 23 individually represent hydrogen, CM 2 alkyl, CM 2 haloalkyl, CM 2 alkoxy, C 3 .
- R 22 and R 23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring is constituted on the basis of these substituents capable of constituting R 22 and R 23 and may further be optionally substituted by a substituent selected from halogen, CM 2 alkyl, CM 2 haloalkyl, nitro, CM 2 alkoxy, cyano, CM 2 haloalkoxy, CM 2 alkylsulfenyl, CM 2 alkylsulfinyl, CM 2 alkylsulfonyl, CM 2 haloalkylsulfenyl, CM 2 haloalkylsulfinyl, CM 2 haloalkylsulfonyl, hydroxy and mercapto;
- R 24 and R 25 individually represent a substituent selected from CM 2 alkyl, CM 2 haloalkyl, C3.8 cycloalkyl, phenyl and phenyl-Ci. 3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, CM 2 alkyl, CM 2 haloalkyl, nitro, CM 2 alkoxy, cyano, CM 2 haloalkoxy, CM 2 alkylsulfenyl, CM 2 alkylsulfinyl, CM 2 alkylsulfonyl, CM 2 haloalkylsulfenyl, CM 2 haloalkylsulfinyl, CM 2 haloalkylsulfonyl, hydroxy and mercapto; and
- R 26 represents a hydrogen atom or CM 2 alkyl.
- the present invention relates to the oxadiazolinone derivative represented by the formula (I), wherein when the heterocyclic ring constituting G is substituted by R 3 ,
- R 3 represents hydrogen, halogen, nitro, cyano, Ci_ 6 alkyl, Ci_ 6 haloalkyl, Ci_ 6 alkoxy, Ci_ 6 haloalkoxy, Ci_ 6 alkylsulfenyl, Ci_ 6 alkylsulfinyl, Ci_ 6 alkylsulfonyl, Ci_ 6 haloalkylsulfenyl, Ci_ 6 haloalkylsulfinyl, Ci_ 6 haloalkylsulfonyl, hydroxy, mercapto or C 3 . 7 cycloalkyl;
- X represents an oxygen or sulfur atom
- R 1 represents Ci_ 6 haloalkyl, Ci_ 6 haloalkoxy, Ci_ 6 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_ 6 alkyl)amino, phenyl- C1-3 alkoxy, phenyl-Ci. 3 alkylsulfenyl, phenyl-Ci. 3 alkylsulfinyl, phenyl-Ci.
- R 2 represents hydrogen, -CH 2 CN, Ci_ 6 alkyl, Ci_ 6 haloalkyl, C 3 . 6 cycloalkyl optionally substituted by a substituent selected from halogen, Ci_ 6 alkyl and Ci_ 6 haloalkyl, benzyl optionally substituted by a substituent selected from halogen, cyano, nitro, Ci_ 6 alkyl, Ci_ 6 haloalkyl, and Ci_ 6 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
- R 21 represents hydrogen, Ci_ 6 alkyl, Ci_ 6 haloalkyl or C 3 . 6 cycloalkyl;
- R 22 and R 23 individually represent hydrogen, Ci_ 6 alkyl, Ci_ 6 haloalkyl, Ci_ 6 alkoxy, C 3 . 7 cycloalkyl, C 2 -6 alkenyloxy or C 2 -6 alkynyloxy, or R 22 and R 23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring is constituted on the basis of these substituents capable of constituting R 22 and R 23 and may further be optionally substituted by a substituent selected from halogen, Ci_ 6 alkyl, Ci_ 6 haloalkyl, nitro, Ci_ 6 alkoxy, cyano, Ci_ 6 haloalkoxy, Ci_ 6 alkylsulfenyl, Ci_ 6 alkylsulfinyl, Ci_ 6 alkylsulfonyl, Ci_ 6 haloalkylsulfenyl, Ci_ 6 haloalkylsulfiny
- R 24 and R 25 individually represent a substituent selected from Ci_ 6 alkyl, Ci_ 6 haloalkyl, C 3 . 7 cycloalkyl, phenyl and phenyl-Ci. 3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, Ci_ 6 alkyl, Ci_ 6 haloalkyl, nitro, Ci_ 6 alkoxy, cyano, Ci_ 6 haloalkoxy, Ci_ 6 alkylsulfenyl, Ci_ 6 alkylsulfinyl, Ci_ 6 alkylsulfonyl, Ci_ 6 haloalkylsulfenyl, Ci_ 6 haloalkylsulfinyl, Ci_ 6 haloalkylsulfonyl, hydroxy and mercapto; and
- R 26 represents a hydrogen atom or Ci_ 6 alkyl.
- the present invention also relates to an insecticide containing the above oxadiazolinone derivative as an active ingredient and an animal parasite control agent containing the above oxadiazolinone derivative as an active ingredient, and use of the oxadiazolinone derivative as an insecticide or an animal parasite control agent.
- C x . y is an abbreviation that means the number of carbon atoms in a substituent within the range of x to y.
- the present invention provides an oxadiazolinone derivative that has high activity and is suitable for use in pest control.
- CM 2 alkyl examples include linear or branched alkyl groups such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert- butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl and n-dodecyl.
- linear or branched alkyl groups having 1 to 6 carbon atoms such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n-pentyl and n-hexyl are preferable.
- a heteroatom means an atom other than a carbon atom, and examples thereof include hydrogen, oxygen, sulfur, nitrogen and phosphorus.
- CM 2 haloalkyi examples include linear or branched haloalkyi such as CH 2 F, CHF 2 , CF 3 , CF 2 CI, CFCI 2 , CF 2 Br, CF 2 CF 3 , CFHCF 3 , CH 2 CF 3 , CFCICF 3 , CCI 2 CF 3 , CF 2 CH 3 , CF 2 CH 2 F, CF 2 CHF 2 , CF 2 CF 2 CI, CF 2 CF 2 Br, CFHCH 3 , CFHCHF 2 , CHFCF 3 , CHFCF 2 CI, CHFCF 2 Br, CFCICF 3 , CCI 2 CF 3 , CF 2 CF 2 CF 3 , CH 2 CF 2 CF 3 , CF 2 CH 2 CF 3 , CF 2 CH 2 CF 3 , CHFCF 2 CF 3 , CHFCF 2 CF 3 , CHFCF 2 CF 3 , CHFCF 2 CF 3
- Ci-6 haloalkyi is preferable.
- Each of these CM 2 haloalkyi and Ci_ 6 haloalkyi groups also includes perfluoroalkyi in which all replaceable hydrogen atoms on the corresponding alkyl have been substituted by fluorine.
- the haloalkyi may further be substituted by an optional substituent.
- CM 2 alkoxy examples include linear or branched alkoxy such as methoxy, ethoxy, n- propoxy, i-propoxy, n-, iso-, sec- or tert-butoxy, pentyloxy and hexyloxy.
- Ci_ 6 alkoxy is preferable. These alkoxy groups may further be substituted by a substituent.
- halogen examples include fluorine, chlorine, bromine and iodine. Fluorine, chlorine and bromine are preferable.
- C 3 . 8 cycloalkyl examples include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
- C 2 _i 2 alkenyl examples include vinyl, allyl, 1-propenyl, 1- (or 2- or 3-)butenyl and 1- pentenyl.
- C 2 . 4 alkenyl is more preferable.
- C 2 _i 2 alkynyl examples include ethynyl, propargyl, 1-propynyl, but-3-ynyl and pent-4- ynyl.
- C 2 . 4 alkynyl is more preferable.
- Aryl is preferably a C 6 -i 2 aromatic hydrocarbon group, and examples thereof include phenyl, naphthyl, and biphenyl. C 6 -io aromatic hydrocarbon groups are preferable, and C 6 aromatic hydrocarbon groups are more preferable.
- a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms can include: saturated rings such as pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, aziridinyl, oxiranyl, thiiranyl, azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl and tetrahydrothiopyranyl; partially saturated rings such as dihydropyrrolyl, dihydroisoxazolyl, dihydropyrazolyl, dihydrooxazolyl and dihydrothiazolyl; and furyl, thienyl, pyrrolyl, isoxazolyl, pyrazolyl, oxazolyl, isothiazolyl, thiazolyl, imi
- the substituent in the phrase "may be substituted by an optional substituent” refers to, for example, amino, hydroxy, oxo, thioxo, halogen, nitro, cyano, isocyano, mercapto, isothiocyanato, carboxy, carboxamido, SF 5 , aminosulfonyl, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, monoalkylamino, dialkylamino, N-alkylcarbonyl-amino, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aryloxycarbonyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, aryloxycarbonyl, alkylcarbonyl,
- haloalkoxyalkylthio, haloalkoxyalkylcarbonyl or haloalkoxyalkyi and preferably refers to chloro, fluoro, bromo, iodo, amino, nitro, cyano, hydroxy, thio or carboxy.
- G is a 6-membered heterocyclic ring comprising, as constituent atoms, at least one nitrogen atom and at least one heteroatom selected from the group consisting of nitrogen, sulfur and oxygen.
- G is more preferably a 6-membered heterocyclic ring comprising at least two nitrogen atoms as constituent atoms, even more preferably a 6-membered heterocyclic ring comprising two nitrogen atoms and four carbon atoms as constituent atoms.
- G is a 6- membered heterocyclic ring comprising two nitrogen atoms and four carbon atoms as constituent atoms
- the positions of the two nitrogen atoms should be ortho and para positions, respectively, relative to the site bonded to the oxadiazolinone ring and should also be ortho positions, relative to the site bonded to R 1 .
- one of the two nitrogen atoms should be flanked by the site bonded to R 1 and the site bonded to the oxadiazolinone ring and the other nitrogen atom should be positioned at para position relative to the site bonded to the oxadiazolinone ring and simultaneously at ortho position relative to the site bonded to R 1 , wherein R 1 is positioned at para position relative to the site bonded to the oxadiazolinone ring.
- G is a 5-membered heterocyclic ring comprising at least one nitrogen atom and, optionally, additional heteroatom(s) as constituent atoms.
- G is more desirably a 5-membered heterocyclic ring comprising one or two nitrogen atoms as constituent atoms and even more desirably comprises one nitrogen atom and four carbon atoms as constituent atoms or two nitrogen atoms and three carbon atoms as constituent atoms.
- R 1 is CM 2 haloalkyl, CM 2 haloalkoxy, CM 2 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylamino, (phenyl)(Ci_i 2 alkyl)amino, phenyl-Ci-i 2 alkoxy, CM 2 haloalkylsulfenyl or CM 2 alkylsulfenyl-Ci_i 2 alkyl, and these substituents may be substituted by a substituent selected from halogen, cyano, CM 2 haloalkyl, Ci-12 alkylsulfenyl-Ci-12 alkyl and CM 2 haloalkoxy.
- R 1 and R 3 are as defined above; and each ring of G1 to G21 may further be substituted by an optional substituent.
- Group 1 Group 2:
- R 1 and R 2 are as defined above
- R 1 and R 2 are as defined above; Group 3: Group 4:
- R 1 and R 2 are as defined above; wherein R 1 and R 2 are as defined above;
- R 1 and R 2 are as defined above.
- R 1 of compounds of formula (I) refers to a substituent comprising a halosubstituted Ci-i 2 alkyl group, e.g. CM 2 haloalkyl; CM 2 haloalkoxy; with CM 2 haloalkyl, CM 2 haloalkoxy, C 2 _i 2 haloalkenyloxy and/or C 2 _i 2 haloalkynyloxy substituted phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_i 2 alkyl)amino, phenyl-Ci-i 2 alkoxy, phenyl-Ci-i 2 alkylsulfenyl, phenyl-Ci-i 2 alkylsulfinyl, phenylamino, (
- R 1 is a substituent selected from the group consisting of Ci. 12 haloalkyl; CM 2 haloalkoxy; with CM 2 haloalkyl, CM 2 haloalkoxy substituted phenyl, phenoxy or pyridyl.
- R 1 represents a substituent comprising a fluorosubstituted Ci_i 2 alkyl group of any of the substituents described in paragraphs [0027] and [0026].
- R 2 represents H or Ci_i 2 alkyl such as methyl.
- the process for producing the oxadiazolinone derivative of the formula (I) of the present invention is not particularly limited, and specifically, the oxadiazolinone derivative of the formula (I) can be produced by the following Production Process (A), (B) or ( ⁇ '):
- This process comprises: ⁇ Step A-1 >
- R 1 and G are as defined above
- R 1 and G are as defined above; subsequently
- R 1 and G are as defined above
- L 1 represents a leaving group, for example, halogen, e.g., chlorine, bromine and fluorine or an alkylsulfonyl or arylsulfonyl group, e.g., methanesulfonyl, trifluoromethanesulfonyl, p-toluenesulfonyl and p-trifluoromethanephenylsulfonyl,
- halogen e.g., chlorine, bromine and fluorine
- an alkylsulfonyl or arylsulfonyl group e.g., methanesulfonyl, trifluoromethanesulfonyl, p-toluenesulfonyl and p-trifluoromethanephenylsulfonyl
- R 1 and G are as defined above, and R 2' is as defined in R 2 with the proviso that hydrogen is not included.
- Each step of Production Process (A) can be performed in accordance with a usual organic synthesis process.
- Examples of the hydroxyamine reagent in ⁇ Step A-1 > can include hydroxyamine hydrochloride, hydroxyamine sulfate, and aqueous hydroxyamine solutions.
- the reaction of ⁇ Step A-1 > can be carried out in an appropriate diluent, and examples of the diluent used therein can include aliphatic hydrocarbons (hexane, cyclohexane, heptane, etc.), aliphatic halogenated hydrocarbons (dichloromethane, chloroform, carbon tetrachloride, dichloroethane, etc.), aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, dibutyl ether, dimethoxyethane (DME), tetrahydrofuran, dioxane, etc.), esters (ethyl acetate, ethyl propionate, etc.), acid amides (dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, etc.), nitriles (acet
- Examples of the appropriate base in ⁇ Step A-1 > can include: alkali metal bases such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium
- Step A-1 can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably 0 and approximately 120°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 0.1 to 48 hours, preferably 2 to 24 hours.
- a hydroxyamine reagent e.g., hydroxylamine hydrochloride in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-1) is reacted in a diluent, for example, ethanol, to obtain the corresponding compound of the formula (lnt-2).
- a diluent for example, ethanol
- Production Process (A) include 4-(pentafluoroethyl)pyrimidine-2-carbonitrile, 4-[2- (trifluoromethyl)phenyl]pyrimidine-2-carbonitrile, 4-[3-(trifluoromethyl)phenyl]pyrimidine-2- carbonitrile, 4-[4-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile, 6-(trifluoromethyl)-pyrimidine- 4-carbonitrile, 4-[2-(trifluoromethyl)phenoxy]pyrimidine-2-carbonitrile and 4-[4- (trifluoromethyl)phenoxy]pyrimidine-2-carbonitrile.
- Production Process (A) include N'-hydroxy-4-(trifluoromethyl)pyrimidine-2-carboximidamide, N'-hydroxy-6-(trifluoromethyl)pyrimidine-4-carboximidamide, N'-hydroxy-2- (trifluoromethyl)pyrimidine-4-carboximidamide, N'-hydroxy-4-[2- (trifluoromethyl)phenyl]pyrimidine-2-carboximidamide, N'-hydroxy-4-[3- (trifluoromethyl)phenyl]pyrimidine-2-carboximidamide, N'-hydroxy-4-[4- (trifluoromethyl)phenyl]pyrimidine-2-carboximidarnide, N'-hydroxy-4-[2- (trifluoromethyl)phenoxy]pyrimidine-2-carboximidarTiide, N'-hydroxy-4-[3- (trifluoromethyl)phenoxy]pyrimidine-2-carboxirnidarTiide and N'-hydroxy-4-[4- (trifluoromethyl)phen
- Examples of the carbonylating agent in ⁇ Step A-2> of Production Process (A) can include carbonyldiimidazole, phenyl chlorocarbonate and phosgene.
- reaction of ⁇ Step A-2> of Production Process (A) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in ⁇ Step A-1 >. Tetrahydrofuran is desirable.
- the reaction of ⁇ Step A-2> of Production Process (A) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in ⁇ Step A-1 >.
- Diazabicycloundecene hereinafter, sometimes abbreviated to "DBU" is desirable.
- Step A-2> of Production Process (A) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 100°C, preferably 0 and approximately 50°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 1 to 30 hours, preferably 3 to 12 hours.
- a carbonylating agent for example, carbonyldiimidazole in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-2) is reacted in a diluent, for example, tetrahydrofuran, and the obtained product is then reacted with a base, for example, DBU in an amount of 1 mol to 3 mol to obtain the corresponding compound of the formula (1-10).
- the compound of the formula (1-10) in Production Process (A) is included in the compound (I) of the present invention.
- Examples thereof include 3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazolidin-5-one, 3-[6-(trifluoromethyl)pyrimidin-4-yl]- 1 ,2,4-oxadiazolidin-5-one and 3-[2-(trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazolidin-5-one.
- the reaction of ⁇ Step A-3> of Production Process (A) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in ⁇ Step A-1 >. Dimethylformamide is desirable.
- the reaction of ⁇ Step A-3> of Production Process (A) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in ⁇ Step A-1 >. Sodium hydride is desirable.
- ⁇ Step A-3> of Production Process (A) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 200°C, preferably 20 and approximately 100°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 1 to 30 hours, preferably 3 to 15 hours.
- a compound of the formula (r-1), for example, iodomethyl benzoate in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (1-10) is reacted in the presence of a base, for example, sodium hydride in an amount of 1 mol to 2 mol in a diluent, for example, dimethylformamide, to obtain the corresponding compound of the formula (1-1 1).
- a base for example, sodium hydride in an amount of 1 mol to 2 mol in a diluent, for example, dimethylformamide
- the compound of the formula (1-1 1) in Production Process (A) is included in the compound (I) of the present invention.
- Examples thereof include 4-methyl-3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5(4H)-one, 4-methyl-3-[6- (trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5(4H)-one, and 4-methyl-3-[2- (trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5(4H)-one.
- the compound of the formula (lnt-1) in Production Process (A) can be produced by Production Process (a), (b), (c), (d), (e), or (f).
- This process comprises reacting a compound represented by the formula (a-1):
- R 1 , L 1 , and G are as defined above
- This process comprises:
- Step b-1 reacting a compound represented by the formula (b-1):
- R 1 is as defined above, and R 4 represents Ci.
- R 5 represents Ci_ 4 alkyl
- This process comprises reacting a compound represented by the formula (c-1): L 1
- Step d-1 a starting compound is reacted with an appropriate alkali metalizing reagent, for example, butyllithium at a temperature of -60°C or lower in an appropriate dehydrated diluent, for example, tetrahydrofuran, and then reacted with dimethylformamide to form aldehyde; and in Step d-2, the aldehyde can be made into a hydroxyimine form through reaction with hydroxyamine hydrochloride at a temperature between 0°C and 70°C in an appropriate diluent, for example, pyridine, and then reacted with acetic anhydride at a temperature between 80°C and 150°C to obtain the object compound.
- an appropriate alkali metalizing reagent for example, butyllithium at a temperature of -60°C or lower in an appropriate dehydrated diluent, for example, tetrahydrofuran
- dimethylformamide to form aldehyde
- Step d-2 the aldehy
- a starting compound in Step e-1 , can be made into an acid chloride form through reaction with an appropriate halogenating agent, for example, oxalyl chloride in an appropriate diluent, for example, dichloromethane, and then reacted with ammonia water to form acid amide; and in Step e-2, the acid amide can be reacted with trifluoromethanesulfonic anhydride in the presence of an appropriate base, for example, triethylamine at a temperature between - 10°C and 30°C in an appropriate diluent, for example, dichloromethane to obtain the object compound.
- an appropriate halogenating agent for example, oxalyl chloride in an appropriate diluent, for example, dichloromethane
- Step f-1 a starting compound can be made into a 4,5-dihydropyrazole form through reaction in an appropriate diluent, for example, ethanol; in Step f-2, the 4,5-dihydropyrazole form is heat-refluxed in the presence of an appropriate acid catalyst, for example, hydrochloric acid and dehydrated to prepare a pyrazole form; in Step f-3, the pyrazole form is oxidized with an appropriate oxidizing agent, for example, potassium permanganate at a temperature between 10°C and 80°C in an appropriate diluent, for example, a water-acetone mixed solvent to prepare a carboxylic acid form; and in Steps f-4 and f-5, reaction can be performed in the same ways as in Steps b-1 and b-2, respectively, to obtain the object compound.
- Production processes (a), (b), (c), (d),(e), and (f) can be performed in accordance with a usual organic synthesis
- Examples of the cyanating agent in Production Process (a) can include sodium cyanide, potassium cyanide, copper cyanide and zinc cyanide.
- the reaction of Production Process (a) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A).
- Dimethyl sulfoxide is desirable.
- Production Process (a) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably 0 and approximately 100°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 0.1 to 48 hours, preferably 3 to 24 hours.
- a cyanating agent for example, sodium cyanide
- a diluent for example, DMSO
- Examples of the compound of the formula (a-1) in Production Process (a) include 2- chloro-4-(trifluoromethyl)pyrimidine, 4-chloro-6-(trifluoromethyl)pyrimidine, 4-chloro-2- (trifluoromethyl)pyrimidine, 2-(methylsulfonyl)-4-[2-(trifluoromethyl)phenyl]pyrimidine, 2- (methylsulfonyl)-4-[3-(trifluoromethyl)phenyl]pyrimidine and 2-(methylsulfonyl)-4-[4- (trifluoromethyl)phenyl]pyrimidine.
- the compound of the formula (a-1) can be produced, for example, by halogenating or sulfonating a compound of the following formula (a-1-1):
- Examples of the compound of the formula (a-1-1) include 4-hydroxy-6- (trifluoromethyl)pyrimidine and 4-hydroxy-2-(trifluoromethyl)pyrimidine.
- the reaction of ⁇ Step b-1 > of Production Process (b) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Water is desirable.
- the reaction of ⁇ Step b-1 > of Production Process (b) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Pyridine is desirable.
- Step b-1 of Production Process (b) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 200°C, preferably 10 and approximately 120°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 1 to 100 hours, preferably 10 to 50 hours.
- a compound of the formula (b-2), for example, S-methylisothiourea sulfate in an amount of 0.5 mol to 2 mol with respect to 1 mol of the compound of the formula (b-1) is reacted in the presence of pyridine as a base in a diluent, for example, water, to obtain the corresponding compound of the formula (b-3).
- Examples of the compound of the formula (b-1) in Production Process (b) include (1 E)- 1-methoxy-4,4,5,5,5-pentafluoropent-1-en-3-one and (1 E)-1-ethoxy-4, 4,5,5, 5-pentafluoropent- 1-en-3-one.
- Examples of the compound of the formula (b-2) in Production Process (b) include methylisothiourea sulfate and S-ethylisothiourea hydrobromide.
- Examples of the compound of the formula (b-3) in Production Process (b) include 2- (methylsulfanyl)-4-(pentafluoroethyl)pyrimidine.
- the reaction of ⁇ Step b-2> of Production Process (b) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified for Production Process (A). Dichloromethane is desirable.
- Examples of the appropriate oxidizing agent in ⁇ Step b-2> of Production Process (b) include chromic acid, pyridium chromate, periodic acid, manganese dioxide, potassium permanganate and m-chloroperoxybenzoic acid (MCPBA). MCPBA is desirable.
- ⁇ Step b-2> of Production Process (b) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 60 and approximately 100°C, preferably between approximately -20 and approximately 50°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- an oxidizing agent for example, MCPBA in an amount of 2 mol to 4 mol with respect to 1 mol of the compound of the formula (b-3) is reacted in a diluent, for example, dichloromethane, to obtain a compound of the formula (b-4).
- Examples of the compound of the formula (b-4) in Production Process (b) include 2- (methylsulfonyl)-4-(pentafluoroethyl)pyrimidine.
- the reaction of Production Process (c) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Dimethylformamide is desirable.
- the reaction of Production Process (c) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Sodium hydride is desirable.
- Production Process (c) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably between 0 and approximately 100°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 0.1 to 24 hours, preferably 1 to 5 hours.
- Examples of the compound of the formula (c-1) in Production Process (c) include 2- chloropyrimidine-4-carbonitrile.
- Examples of the compound of the formula (c-2) in Production Process (c) include 2,2,2-trifluoroethanethiol.
- the compound of the formula (b-3) in Production Process (b) can be produced by Production Process (g) or (h) shown below.
- This process comprises: ⁇ Step g-1 >
- R 1 , R 5 , and G are as defined above.
- This process comprises reacting a compound represented by the formula (g-1):
- V represents O or NH
- R 6 is as defined above
- the reaction of Production Process (g) can be performed in accordance with the process disclosed in WO2004/762.
- the reaction of Production Process (g) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Dimethoxyethane and water are desirable.
- the reaction of Production Process (g) can be carried out in the presence of an appropriate catalyst, and examples of the catalyst used therein include
- Tetrakis(triphenylphosphine)palladium is desirable.
- the reaction of Production Process (g) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Potassium carbonate is desirable.
- the reaction of Production Process (g) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 250°C, preferably between 50 and approximately 150°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 0.1 to 24 hours, preferably 1 to 5 hours.
- a compound of the formula (g-2) in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (g-1) is reacted in the presence of tetrakis(triphenylphosphine)palladium as a catalyst and potassium carbonate as a base in a diluent, for example, dimethoxyethane and water, to obtain the corresponding compound of the formula (b-3).
- a diluent for example, dimethoxyethane and water
- Production Process (b) examples of the compound of the formula (g-1) in Production Process (h) include 4-chloro-2-(methylsulfanyl)pyrimidine.
- Examples of the compound of the formula (h-1) in Production Process (h) include 2,2,2- trifluoroethanol.
- This process comprises reacting a compound represented by the formula (1-12):
- R 1 , R 2 , and G are as defined above
- R 1 , R 2 , and G are as defined above
- This process comprises reacting a carboximidamide intermediate represented by the formula (lnt-2):
- R 1 and G are as defined above
- R 1 , R 2 , and G are as defined above
- R 2 represents hydrogen
- Examples of the sulfurizing agent used in Production Process (B) can include diphosphorus pentasulfide and Lawesson's reagents.
- the reaction of Production Process (B) can be carried out in an appropriate diluent, and examples of the diluent used therein can include the same as those exemplified in Production Process (A), preferably toluene.
- the reaction of Production Process (B) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately 0 and approximately 200°C, preferably between 20 and approximately 150°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 1 to 20 hours, preferably 3 to 10 hours.
- Examples of the thiocarbonylating agent in Production Process ( ⁇ ') can include thiocarbonyldiimidazole and thiophosgene.
- the reaction of Production Process ( ⁇ ') can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Tetrahydrofuran is desirable.
- the reaction of Production Process ( ⁇ ') can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). DBU is desirable.
- Production Process ( ⁇ ') can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 100°C, preferably between 0 and approximately 50°C.
- the reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
- the reaction time is 1 to 30 hours, preferably 3 to 12 hours.
- a thiocarbonylating agent for example, thiocarbonyldiimidazole in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-2) is reacted in a diluent, for example, tetrahydrofuran, and then the obtained product is reacted with a base, for example, DBU, in an amount of 1 mol to 3 mol to obtain the corresponding compound of the formula (1-13).
- the compound of the formula (1-13) in Production Process ( ⁇ ') is included in the compound (I) of the present invention.
- Examples thereof include 3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazole-5(4H)-thione.
- the oxadiazolinone derivative of the present invention usually exhibits potent insecticidal effect and can be used as an insecticide. Furthermore, the oxadiazolinone derivative of the present invention usually exhibits potent disinfesting effect on harmful insects with no or little harmful adverse drug side effect to cultivated plants. Thus, the oxadiazolinone derivative of the present invention can be used for disinfesting a wide range of pest species, for example, harmful sucking insects, chewing insects, and other plant-parasitic pests, stored product insects, and hygiene pests, and can be applied for the purpose of disinfesting or exterminating them. Examples of the harmful pests include the following:
- coleopterans such as Callosobruchus chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus and Aulacophora femoralis; lepidopterans such as Lymantria dispar, Malacosoma neustria, Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis, Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotisfucosa, Galleria mellonella, Plutella maculipennis, Heliothis
- Pseudococcus comstocki Unapsis yanonensis, Myzus persicas, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nezara spp., Trialeurodes vaporariorm and Psylla spp.; thysanopterans such as Thrips palmi and Franklinella occidental; orthopterans such as Blatella germanica, Periplaneta americana, Gryllotalpa Africana and Locusta migratoria migratoriodes; isopterans such as Reticulitermes speratus and Coptotermes formosanus; dipterans such as Musca domestica, Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles sinensis, Culex tritaeniorhynchus, Liriomyza torifolii.
- nematodes for example, Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et Kiyohara, Aphelenchoides besseyi, Heterodera glycines, and Pratylenchus spp.
- the oxadiazolinone derivative of the present invention shows excellent plant tolerance and preferable toxicity to warm-blooded animals and is well tolerated by the environment, and thus is suitable for protecting plants and plant parts.
- the application of the oxadiazolinone derivative of the present invention can bring about increased harvest yields and improved quality of harvested materials.
- the compound is further suitable for disinfesting harmful pests, particularly, insects, arachnids, helminths, nematodes and mollusks, which are encountered in the protection of stored products and the protection of materials, in the hygiene field, agriculture, horticulture or the veterinary field and in forests, gardens or recreational facilities.
- the compound of the present invention can be used preferably as a plant protectant.
- the oxadiazolinone derivative of the present invention has activity against normally sensitive or resistant species and against all or some of stages of growth.
- the above pests particularly include the following: [0112] From the order Anoplura (Phthiraptera), for example, Damalinia spp., Haematopinus, Linognathus spp., Pediculus spp. and Trichodectes spp.
- Anoplura for example, Damalinia spp., Haematopinus, Linognathus spp., Pediculus spp. and Trichodectes spp.
- Arachnida for example, Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranyctus spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Oligonychus spp., Ornithodoros spp.,
- Panonychus spp. Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp. and Vasates lycopersici.
- Gastropoda for example, Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp. and Succinea spp.
- helminths for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus
- the compound of the present invention can further disinfest protozoans such as Eimeria.
- Hymenoptera From the order Hymenoptera, for example, Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis and Vespa spp.
- Thynsanoptera for example, Basothrips biformis, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Kakothrips spp.,
- Thysanura for example, Lepisma saccharina.
- phytoparasitic nematodes examples include Anguina spp., Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp.,
- Heliocotylenchus spp. Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp., Tylenchorhynchus spp., Tylenchulus spp., Thlenchulus semipenetrans and Xiphinema spp.
- every plant and every part of plants can be treated.
- the plants mean all plants and plant populations such as desirable or undesirable wild plants or grain plants (including naturally growing grain plants).
- the grain plants can be plants that can be obtained by routine plant breeding and optimization methods, by biotechnological and genetic engineering methods or by combinations of these methods. These grain plants include transgenic plants and encompass plant varieties that may or may not be protected by plant breeders' rights.
- the parts of plants mean every part or organ of plants above or below the ground, such as buds, leaves, flowers, and roots. Examples thereof can also include leaves, needles, stems, trunks, flowers, fruit bodies, fruits, seeds, roots, tubers and subterranean stems.
- the parts of plants also include collected substances, and vegetatively or reproductively propagating substances, for example, cuttings, tubers, subterranean stems, lateral braches and seeds.
- the treatment of the plants or the parts of plants with the active compound according to the present invention is carried out either directly or by allowing the compound to act on the surroundings, habitats or storage areas of the plants or the parts of plants by routine treatment methods, for example, dipping, spraying, vaporization, atomization, scattering, application and injection, or for propagating substances particularly for seeds, by application of one or more coatings.
- the compound of the present invention exhibits permeable effect, which means that the compound is capable of penetrating through a plant body and moving in the parts of plants from under to above the ground.
- plants and their parts can be treated according to the present invention.
- wild plant species and plant cultivars or those obtained by traditional biological breeding methods such as hybridization or protoplast fusion and the parts thereof are treated.
- transgenic plants and plant varieties (genetically modified organisms) obtained by appropriate combinations of genetic engineering methods with conventional methods and the parts thereof are treated.
- the terms "parts” and "parts of plants” are as described above.
- plants of varieties which are commercially available or in use are treated according to the present invention in each case.
- the plant varieties mean plants with novel properties ("traits"), which are obtained by conventional breeding, mutagenesis or recombinant DNA techniques. They can be plant varieties, biotypes or genotypes.
- the treatment according to the present invention can bring about superadditive ("synergistic") effects depending on plant species or plant varieties, their locations and propagation conditions (soil, climate, growth period, and nutrition).
- the treatment according to the present invention can probably result in, for example, reduced application rates and/or expanded activity spectra and/or increased activities of substances and compositions available according to the present invention, improved plant growth, increased tolerance to high or low temperatures, increased tolerance to droughts or to water or soil salt contents, improved flowering performance, simplified collection, accelerated maturation, increased harvest yields, improved quality and/or increased nutritional values of collected products, and improved storage stability and/or processability of collected products, which exceed actually expected effects.
- the preferable transgenic plants or plant varieties (obtained by genetic engineering) treated in accordance with the present invention include all plants that have received, by means of genetic modification, genetic materials imparting exceedingly advantageous and useful traits to these plants.
- examples of such properties include improved plant growth, increased tolerance to high or low temperatures, increased tolerance to droughts or to water or soil salt contents, improved flowering performance, simplified collection, accelerated maturation, increased harvest yields, improved quality and/or increased nutritional values of collected products, and improved storage stability and/or processability of collected products.
- traits are further and particularly emphasized include improved defense of plants against harmful pests and microorganisms such as insects, mites, phytopathogenic fungi, bacteria and/or viruses, and increased tolerance of plants to certain herbicidally active compounds.
- transgenic plants can include: important grain plants such as grains (wheat and rice), maize, soy bean, potato, sugar beet, tomato, bean, and other vegetable cultivars, cotton, tobacco and rapeseed; and fruit plants such as those bearing fruits, for example, apples, pears, citrus fruits and grapes. Particularly, maize, soy bean, potato, cotton, tobacco and rapeseed are important.
- important grain plants such as grains (wheat and rice), maize, soy bean, potato, sugar beet, tomato, bean, and other vegetable cultivars, cotton, tobacco and rapeseed
- fruit plants such as those bearing fruits, for example, apples, pears, citrus fruits and grapes.
- maize, soy bean, potato, cotton, tobacco and rapeseed are important.
- Traits that are emphasized are, particularly, increased defense of plants against insects, arachnids, nematodes, slugs and snails attributed to toxins formed in the plants, particularly, toxins formed in the plants by genetic materials derived from Bacillus thuringiensis (e.g., by genes CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2, Cry9c, Cry2Ab, Cry3Bb and CrylF, and combinations thereof) (hereinafter, referred to as "Bt plants").
- Bacillus thuringiensis e.g., by genes CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2, Cry9c, Cry2Ab, Cry3Bb and CrylF, and combinations thereof
- Traits that are also particularly emphasized are increased defense of plants against fungi, bacteria, and viruses attributed to systemic acquired resistance (SAR), systemin, phytoalexin, elicitors, and resistance genes, and corresponding expressed proteins and toxins. Further traits that are particularly emphasized are increased tolerance of plants to certain herbicidally active compounds, for example, imidazolinone, sulfonylurea, glyphosate or phosphinotricin (e.g., "PTA” genes). Genes that impart the desired traits may be allowed to exist in combination with one another in the transgenic plants.
- SAR systemic acquired resistance
- PTA phosphinotricin
- Bt plants can include maize, cotton, soy bean and potato cultivars sold under the trade names YIELD GARD (R) (e.g., maize, cotton and soy bean), KnockOut (R) (e.g., maize), Starl_ink (R) (e.g., maize), Bollgard (R) (cotton), Nucotn (R) (cotton) and NewLeaf (R) (potato).
- Examples of the plants tolerant to herbicides can include maize, cotton and soy bean cultivars sold under the trade names Roundup Ready (R) (tolerance to glyphosate; e.g., maize, cotton and soy beans), Liberty Link (R) (tolerance to phosphinotricin; e.g., rapeseed), IMI (R) (tolerance to imidazolinones) and STS (R) (tolerance to sulfonylurea; e.g., maize).
- Examples of the plants resistant to herbicides include cultivars sold under the name Clearfield (R) (e.g., maize).
- Clearfield e.g., maize
- the listed plants can be treated particularly advantageously with the oxadiazolinone derivative of the present invention at an appropriate concentration.
- the novel compound of the present invention can further be used effectively against various harmful parasitic pests (entozoan and ectozoan), for example, insects and helminths, in the veterinary field.
- harmful parasitic pests include those described below.
- insects include Gasterophilus spp., Stomoxys spp., Trichodectes spp., Rhodonius spp., Ctenocephalides canis, Cimx lecturius, Ctenocephalides felis and Lucilia cuprina.
- Examples of acari include Ornithodoros spp., Ixodes spp. and Boophilus spp.
- the active compound of the present invention is active against parasitic animals, particularly, ectoparasites or endoparasites, in the field of veterinary specialists, i.e., in the veterinary field.
- the term endoparasite particularly includes helminths such as cestodes, nematodes and trematodes, and protozoans such as Coccidia.
- the ectoparasites are typically and preferably arthropods, particularly, insects such as flies (biting and licking flies), parasitic fly larvae, lice, hair lice, bird lice and flea, or Acarina such as mites, for example, hard ticks, soft ticks, scab mites, harvest mites and bird mites.
- Anoplurida for example, Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp. and Solenopotes spp.
- Linognathus setosus Linognathus setosus
- Linognathus vituli Linognathus ovillus
- Linognathus oviformis Linognathus pedalis
- Linognathus stenopsis Haematopinus asini macrocephalus
- Haematopinus eurysternus Haematopinus suis
- Pediculus humanus capitis Pediculus humanus corporis
- Phylloera vastatrix Phthirus pubis and Solenopotes capillatus.
- Nematocerina and Brachycerina for example, Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp.,
- Phlebotomus spp. Lutzomyia spp., Culicoides spp., Chrysops spp., Odagmia spp., Wilhelmia spp., Hybomitora spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp.
- Aedes aegypti Aedes albopictus, Aedes taeniorhynchus, Anopheles gambiae, Anopheles maculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Fannia canicularis, Sarcophaga carnaria, Stomoxys calcitrans, Tipula paludosa, Lucilia cuprina, Lucilia sericata, Simulium reptans, Phlebotomus papatasi,
- Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans and Xenopsylla cheopsis.
- Ornithonyssus spp. Pneumonyssus spp.
- Raillietia spp. Pneumonyssus spp.
- Sternostoma spp. Varroa spp.
- Argas persicus Argas reflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus (Boophilus) microplus, Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) annulatus, Rhipicephalus (Boophilus) calceratus, Hyalomma annatolicum, Hyalomma aegypticum, Hyalomma marginatum, Hyalomma transiens, Rhipicephalus evertsi, Ixodes ricinus, Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna, Haemaphysalis punctata, Haemaphysalis cinnabarina, Hae
- Rhipicephalus appendiculatus Rhipicephalus capensis, Rhipicephalus turanicus, Rhipicephalus zambeziensis, Amblyomma americanum, Amblyomma variegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyomma cajennense, Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssus sylviarum and Varroa jacobsoni;
- Caloglyphus spp. Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp. and Laminosioptes spp.
- the oxadiazolinone derivative of the present invention is also suitable for disinfesting arthropods, helminths and protozoans that attack animals.
- the animals include agricultural livestock such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, chickens, turkeys, ducks, geese, cultured fishes and honeybees.
- the animals further include, for example, pet animals (also referred to as companion animals) such as dogs, cats, cage birds and aquarium fishes, and animals known as experimental animals such as hamsters, guinea pigs, rats and mice.
- the term "disinfest” used herein as to the veterinary field means that the active compound is effective in reducing the incidence of parasite in each animal infected with such a parasite to harmless levels. More specifically, the term “disinfest” used herein means that the active compound is effective in killing each parasite, inhibiting its growth or inhibiting its propagation.
- the oxadiazolinone derivative of the present invention when used in the treatment of animals, can be applied directly.
- the compound of the present invention is applied as pharmaceutical compositions which may contain pharmaceutically acceptable excipients and/or auxiliaries publicly known in the art.
- the active compound may be formulated as shampoo, appropriate preparations available in aerosols or unpressurized sprays such as pump sprays and atomizer sprays.
- the active compound of the present invention when used for livestock, poultry, pet animals and the like, can be applied, either directly or after dilution (e.g., 100- to 10,000-fold dilution), as preparations (e.g., powders, wettable powders ["WP”], emulsions, emulsifiable concentrates ["EC”], flowables, homogeneous solutions and suspension concentrates ["SC”]) containing the active compound in an amount of 1 to 80% by weight (% by mass as an SI unit), or can be used as an immersion bath thereof.
- dilution e.g., 100- to 10,000-fold dilution
- preparations e.g., powders, wettable powders ["WP"], emulsions, emulsifiable concentrates ["EC”], flowables, homogeneous solutions and suspension concentrates ["SC”]
- preparations e.g., powders, wettable powders ["WP"],
- the active compound of the present invention when used in the veterinary field, may be used in combination with appropriate synergists or other active compounds, such as miticides, insecticides, anthelmintics and antiprotozoal drugs.
- insecticides substances having insecticidal effect on pests including all of them are referred to as insecticides.
- the active compound of the present invention can be prepared in conventional dosage forms, when used as an insecticide.
- the dosage forms include solutions, emulsions, wettable powders, water-dispersible granules, suspensions, powders, foams, pastes, tablets, granules, aerosols, active compound-impregnated natural and synthetic substances, microcapsules, seed coating agents, preparations used with a combustion apparatus (e.g., smoking or fuming cartridges, cans and coils as combustion apparatuses) and ULV (cold or warm mist).
- a combustion apparatus e.g., smoking or fuming cartridges, cans and coils as combustion apparatuses
- ULV cold or warm mist
- the preparations can be produced, for example, by mixing the active compound with a developer i.e., a liquid diluent or carrier, a liquefied gas diluent or carrier, or a solid diluent or carrier, and optionally with a surfactant i.e., an emulsifier and/or a dispersant and/or a foaming agent.
- a developer i.e., a liquid diluent or carrier, a liquefied gas diluent or carrier, or a solid diluent or carrier
- a surfactant i.e., an emulsifier and/or a dispersant and/or a foaming agent.
- an organic solvent can also be used as an auxiliary solvent.
- liquid diluent or carrier examples include aromatic hydrocarbons (e.g., xylene, toluene and alkylnaphthalene), chlorinated aromatic or chlorinated aliphatic hydrocarbons (e.g., chlorobenzene, ethylene chloride and methylene chloride), aliphatic hydrocarbons (e.g., cyclohexane), paraffin (e.g., mineral oil fractions), alcohols (e.g., butanol or glycol and their ethers or esters), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone), strong polar solvents (e.g., dimethylformamide and dimethyl sulfoxide) and water.
- aromatic hydrocarbons e.g., xylene, toluene and alkylnaphthalene
- chlorinated aromatic or chlorinated aliphatic hydrocarbons
- the liquefied gas diluent or carrier can be, for example, those in a gas state at normal temperature and normal pressure, such as aerosol propellants including butane, propane, nitrogen gas, carbon dioxide and halogenated hydrocarbon.
- solid diluent examples include pulverized natural minerals (e.g., kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite and diatomaceous earth) and pulverized synthetic minerals (e.g., highly dispersed silicic acid, alumina and silicate).
- pulverized natural minerals e.g., kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite and diatomaceous earth
- pulverized synthetic minerals e.g., highly dispersed silicic acid, alumina and silicate.
- Examples of the solid carrier for granules include pulverized and sieved rocks (e.g., calcite, marble, pumice, sepiolite, and dolomite), synthetic granules of inorganic or organic powder and fine particles of organic materials (e.g., sawdust, coconuts, corncobs and tobacco stems).
- pulverized and sieved rocks e.g., calcite, marble, pumice, sepiolite, and dolomite
- synthetic granules of inorganic or organic powder and fine particles of organic materials e.g., sawdust, coconuts, corncobs and tobacco stems.
- emulsifier and/or the foaming agent examples include: nonionic or anionic emulsifiers such as polyoxyethylene fatty acid ester, polyoxyethylene fatty acid alcohol ether (e.g., alkylaryl polyglycol ether), alkylsulfonate, alkylsulfate and arylsulfonate; and albumin hydrolysates.
- nonionic or anionic emulsifiers such as polyoxyethylene fatty acid ester, polyoxyethylene fatty acid alcohol ether (e.g., alkylaryl polyglycol ether), alkylsulfonate, alkylsulfate and arylsulfonate; and albumin hydrolysates.
- Examples of the dispersant include lignin-sulfite waste liquors and methylcellulose.
- a fixative may also be used in the preparations (powders, granules or emulsions), and examples of the fixative include carboxymethylcellulose and natural or synthetic polymers (e.g., gum arabic, polyvinyl alcohol and polyvinyl acetate).
- a colorant may also be used, and examples of the colorant include inorganic pigments (e.g., iron oxide, titanium oxide and Prussian Blue), organic dyes (e.g., alizarin dyes, azo dyes and metallophthalocyanine dyes), and further, trace elements such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts.
- the preparations can generally contain the active ingredient in an amount ranging from 0.1 to 95% by weight, preferably 0.5 to 90% by weight.
- the oxadiazolinone derivative of the present invention can also exist as mixtures with other active compounds, for example, insecticides, toxic feed, bactericides, miticides, nematicides, fungicides, growth regulators and herbicides, in their commercially useful preparation forms and in application forms prepared from these preparations.
- active compounds for example, insecticides, toxic feed, bactericides, miticides, nematicides, fungicides, growth regulators and herbicides, in their commercially useful preparation forms and in application forms prepared from these preparations.
- concentration of the active compound of the present invention in actual use can be, for example, in the range of 0.0000001 to 100% by weight, preferably 0.00001 to 1 % by weight.
- the oxadiazolinone derivative of the present invention can be used through conventional methods suitable for usage patterns.
- the oxadiazolinone derivative of the present invention has stability effective against alkali on lime materials when used against hygiene pests and pests infesting stored products, and also exhibits excellent residual effect on wood and soil.
- the active compound of the present invention is also low toxic to warm-blooded animal and can be used safely.
- N'-hydroxy-4-(trifluoromethyl)pyrimidine-2-carboximidamide (0.5 g) was dissolved in tetrahydrofuran and carbonyldiimidazole (0.43 g) was added thereto. The mixture was stirred at room temperature for 2 hours. Then, DBU (0.43 ml_) was added thereto, and the mixture was stirred at room temperature for 20 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. Then, the organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[4-(trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5-one
- N'-Hydroxy-4-(pentafluoroethyl)pyrimidine-2-carboximidamide (0.2 g) was dissolved in tetrahydrofuran, and carbonyldiimidazole (0.14 g) was added thereto. The mixture was stirred at room temperature for 2 hours. Then, DBU (0.14 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. Then, the organic layer was dried over anhydrous magnesium sulfate.
- N'-Hydroxy-4-(2,2,2-trifluoroethoxy)pyrirnidine-2-carboxirnidarTiide (0.22 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.17 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.17 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate.
- N'-[(Phenoxycarbonyl)oxy]-6-(trifluoromethyl)pyrimidine-4-carboximidami (0.22 g) was dissolved in chlorobenzene, and the solution was irradiated with microwave at 180°C for 1.5 hours. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[6-(trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5-one (0.04 g).
- N'-Hydroxy-2-(trifluoromethyl)pyrimidine-4-carboximidamide (0.18 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.16 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.16 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate.
- N'-Hydroxy-2-(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carboximidamide (0.2 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.14 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.16 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate.
- Carbonyldiimidazole (0.47 g) was added to a tetrahydrofuran solution (8 ml) of N'- hydroxy-1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboximidamide (0.5 g) in an argon atmosphere, and the mixture was stirred at room temperature for 2 hours.
- DBU (0.44 g) was added thereto, and stirring was continued for additional 6 hours.
- 10% hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate.
- Carbonyldiimidazole (1.67 g) was added to a tetrahydrofuran solution (28 ml) of N'- hydroxy-1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboximidamide (1.79g) in an argon atmosphere, and the mixture was stirred at room temperature for 2 hours.
- DBU (1.57 g) was added thereto, and stirring was continued for additional 6 hours.
- 2 N hydrochloric acid was added thereto at 0°C, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate.
- n- normal-, c-hex: cyclohexyl, c-pen: cyclopentyl, c-hep: cycloheptyl, c-pro:
- Emulsifier 1 part by weight of polyoxyethylene alkylphenyl ether
- Ammonium salt or ammonium salt and penetration enhancer in a dosage of l OOOppm are added to the desired concentration if necessary.
- Emulsifier 1 part by weight polyoxyethylene alkyl phenyl ether
- Emulsifier 1 part by weight polyoxyethylene alkyl phenyl ether
- kidney bean seedlings Paneolus vulgaris
- About 20 adults of the two-spotted spider mite (Tetranychus urticae) are inoculated onto each leaf, about 40 adults and some nymphs per pot.
- a paper label is placed on each pot.
- acaricidal activity After 2 days, the acaricidal activity is calculated. An acaricidal activity of 100 % means that all mites have been killed, an acaricidal activity of 0 % means that no mites have been killed. [0275] In this test the following compounds showed an acaricidal activity of 98% at an active compound concentration of 500ppm: G1-52, G15-103
- acaricidal activity After 6 days, the acaricidal activity is calculated. An acaricidal activity of 100 % means that all mites have been killed, an acaricidal activity of 0 % means that no mites have been killed.
- Emulsifier 1 part by weight polyoxyethylene alkyl phenyl ether
- Tomato seedlings (Lycopersicon esculentum) are treated by being sprayed with the desired concentration of the compound solution. After drying, the treated pots are placed in the greenhouse where they are inoculated with the silverleaf whitefly (Bemisia argentifolii) for an infection-time of 24h. Afterwards, the plants are placed in a room at 25°C and 50-60 % r.h., with 16L8D lighting conditions.
- insecticidal activity After 14 days, the insecticidal activity is calculated. An insecticidal activity of 100 % means that all whiteflies have been killed, an insecticidal activity of 0 % means that no whiteflies have been killed. [0284] In this test the following compounds showed an insecticidal activity of 90% at an active compound concentration of 100ppm: G16-1.
- Emulsifier Polyoxyethylene alkyl phenyl ether, 1 part by weight
- the compound solutions are sprayed to a cucumber seedling (Cucumis sativus). After drying, the treated plant is placed in a plastic stand. About 100 thrips-eggs (Thrips palmi) on a piece of filter paper are attached to the plant and covered with a cage to keep 100% humidity. The plant is kept in a room at 23°C.
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Abstract
The present invention provides an oxadiazolinone derivative represented by the formula (I) suitable for use in pest control: wherein G represents a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms, and the heterocyclic ring may be substituted by R3, with the proviso that when G represents a pyridine ring substituted by R3 and when the nitrogen atom in the pyridine ring is at an ortho position relative to the carbon atom bonded to the oxadiazolinone ring, the positions of the carbon atom bonded to R1 and the carbon atom bonded to R3 are each limited to any positon selected from the ortho and meta positions relative to this nitrogen atom; R3 represents hydrogen, halogen, nitro, cyano, C1-12 alkyl, C1-12 haloalkyl, C1-12 alkoxy, C1-12 haloalkoxy, or the like; X represents an oxygen or sulfur atom; R1 represents C1-12 haloalkyl, C1-12 haloalkoxy, C1-12 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, or the like; and R2 represents hydrogen, -CH2CN, C1-12 alkyl, C1-12 haloalkyl, or the like.
Description
OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL
[0001] The present invention relates to a novel oxadiazolinone derivative and use thereof in pest control.
[0002] Oxadiazolinone compounds are known to be useful as pest control agents.
[0003] For example, WO 2010/035899 discloses a compound in which an oxadiazolinone ring and an aromatic group such as a phenyl group are bonded at ortho and para positions, respectively, relative to nitrogen in a pyridine ring.
[0004] Moreover, WO 2009/066786 discloses a compound in which an oxadiazolinone ring and a group such as a haloalkyl group are bonded at ortho and para positions, respectively, relative to nitrogen in a pyridine ring.
[0005] Furthermore, JP Patent Application Publication No. 2002-205991 discloses a compound in which an oxadiazolinone ring and a trifluoromethyl group are bonded at meta and para positions, respectively, relative to nitrogen in a pyridine ring.
[0006] Although conventional techniques typified by Patent Literatures 1 to 3 disclose oxadiazolinone compounds with various structures, as described above, there is still a great demand on oxadiazolinone derivatives with a novel structure having high activity.
[0007] Thus, the object of the present invention is to provide an oxadiazolinone derivative that has a novel structure and is suitable for use in pest control.
[0008] The present inventors have diligently studied to develop a novel compound that exhibits higher effect as an insecticide and has a broad spectrum thereas and have consequently accomplished the present invention this time by finding a novel oxadiazolinone derivative that is available for use in pest control. Specifically, the present invention relates to an
oxadiazolinone derivative represented by the formula (I):
G represents a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms, and the heterocyclic ring may be substituted by R3, with the proviso that when G represents a pyridine ring substituted by R3 and when the nitrogen atom in the pyridine ring is at an ortho position relative to the carbon atom bonded to the oxadiazolinone ring, the positions of the carbon atom bonded to R1 and the carbon atom bonded to R3 are each limited to any position selected from the ortho and meta positions relative to this nitrogen atom;
R3 represents hydrogen, halogen, nitro, cyano, CM2 alkyl, CM2 haloalkyi, CM2 alkoxy, Ci-12 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, Ci-12 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy, mercapto or C3.8 cycloalkyl;
X represents an oxygen or sulfur atom;
R1 represents CM2 haloalkyi, CM2 haloalkoxy, CM2 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_i2 alkyl)amino, phenyl- Ci-12 alkoxy, phenyl-Ci_i2 alkylsulfenyl, phenyl-Ci_i2 alkylsulfinyl, phenyl-Ci_i2 alkylsulfonyl, phenyl-Ci-i2 alkylamino, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM 2
haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, CM2 alkylsulfinyl-Ci-i2 alkyl, Ci. 12 alkylsulfonyl-Ci-12 alkyl, CM2 haloalkylsulfenyl-Ci-i2 alkyl, CM2 haloalkylsulfinyl-Ci-i2 alkyl, Ci. 12 haloalkylsulfonyl-Ci-i2 alkyl, C2-12 alkenyloxy, C2-12 haloalkenyloxy, C2-12 alkynyloxy, C2-12 haloalkynyloxy, (CM2 alkyl)3 silyloxy or hydroxy, and these substituents can be optionally substituted by a substituent(s) selected from halogen, cyano, amino, mercapto, CM2 alkyl, Ci- 12 haloalkyi, CM2 haloalkoxy, C2-12 alkenyloxy, C2-12 haloalkenyloxy, C2-12 alkynyloxy, C2-12 haloalkynyloxy, CM2 alkylsulfenyl-Ci.12 alkyl and hydroxy; and
R2 represents hydrogen, -CH2CN, CM2 alkyl, CM2 haloalkyi, C3.8 cycloalkyl which may be optionally substituted by a substituent(s) selected from halogen, CM2 alkyl and CM 2 haloalkyi, benzyl which may be optionally substituted by a substituent selected from halogen, cyano, nitro, CM2 alkyl, CM2 haloalkyi and CM2 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
Q l Q 2 Q 3 Q 4 Q 5
wherein, in each of the formulas Q1 to Q5,
a bond marked with * represents a bond with the nitrogen atom bonded to R2 in the formula (I);
R21 represents hydrogen, CM2 alkyl, CM2 haloalkyi or C3.8 cycloalkyl;
R22 and R23 individually represent hydrogen, CM2 alkyl, CM2 haloalkyl, CM2 alkoxy, C3.8 cycloalkyl, C2-12 alkenyloxy or C2-12 alkynyloxy, or R22 and R23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring is constituted on the basis of these substituents capable of constituting R22 and R23 and may further be optionally substituted by a substituent selected from halogen, CM2 alkyl, CM2 haloalkyl, nitro, CM2 alkoxy, cyano, CM2 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy and mercapto;
R24 and R25 individually represent a substituent selected from CM2 alkyl, CM2 haloalkyl, C3.8 cycloalkyl, phenyl and phenyl-Ci.3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, CM2 alkyl, CM2 haloalkyl, nitro, CM2 alkoxy, cyano, CM2 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy and mercapto; and
R26 represents a hydrogen atom or CM2 alkyl.
[0009] In one embosiment, the present invention relates to the oxadiazolinone derivative represented by the formula (I), wherein when the heterocyclic ring constituting G is substituted by R3,
R3 represents hydrogen, halogen, nitro, cyano, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 alkoxy, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy, mercapto or C3.7 cycloalkyl;
X represents an oxygen or sulfur atom;
R1 represents Ci_6 haloalkyl, Ci_6 haloalkoxy, Ci_6 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_6 alkyl)amino, phenyl- C1-3 alkoxy, phenyl-Ci.3 alkylsulfenyl, phenyl-Ci.3 alkylsulfinyl, phenyl-Ci.3 alkylsulfonyl, phenyl- Ci-3 alkylamino, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, Ci_6 alkylsulfinyl-Ci_3 alkyl, Ci_6 alkylsulfonyl-Ci_3 alkyl, Ci-6 haloalkylsulfenyl-Ci-3 alkyl, Ci_6 haloalkylsulfinyl-Ci-3 alkyl, Ci_6 haloalkylsulfonyl-Ci_3 alkyl, C2-6 alkenyloxy, C2.6 haloalkenyloxy, C2.6 alkynyloxy, C2.6 haloalkynyloxy, (Ci_6 alkyl)3 silyloxy or hydroxy, and these substituents can be optionally substituted by a substituent(s) selected from halogen, cyano, amino, mercapto, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 haloalkoxy, C2.6 alkenyloxy, C2. 6 haloalkenyloxy, C2.6 alkynyloxy, C2.6 haloalkynyloxy, Ci_6 alkylsulfenyl-Ci_3 alkyl and hydroxy; and
R2 represents hydrogen, -CH2CN, Ci_6 alkyl, Ci_6 haloalkyl, C3.6 cycloalkyl optionally substituted by a substituent selected from halogen, Ci_6 alkyl and Ci_6 haloalkyl, benzyl optionally substituted by a substituent selected from halogen, cyano, nitro, Ci_6 alkyl, Ci_6
haloalkyl, and Ci_6 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
Q 1 Q 2 Q 3 Q 4 Q 5
wherein, in each of the formulas Q1 to Q5,
a bond marked with * represents a bond with the nitrogen atom bonded to R2 in the formula (I);
R21 represents hydrogen, Ci_6 alkyl, Ci_6 haloalkyl or C3.6 cycloalkyl;
R22 and R23 individually represent hydrogen, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 alkoxy, C3.7 cycloalkyl, C2-6 alkenyloxy or C2-6 alkynyloxy, or R22 and R23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring is constituted on the basis of these substituents capable of constituting R22 and R23 and may further be optionally substituted by a substituent selected from halogen, Ci_6 alkyl, Ci_6 haloalkyl, nitro, Ci_6 alkoxy, cyano, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy and mercapto;
R24 and R25 individually represent a substituent selected from Ci_6 alkyl, Ci_6 haloalkyl, C3.7 cycloalkyl, phenyl and phenyl-Ci.3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, Ci_6 alkyl, Ci_6 haloalkyl, nitro, Ci_6 alkoxy, cyano, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy and mercapto; and
R26 represents a hydrogen atom or Ci_6 alkyl.
[0010] The present invention also relates to an insecticide containing the above oxadiazolinone derivative as an active ingredient and an animal parasite control agent containing the above oxadiazolinone derivative as an active ingredient, and use of the oxadiazolinone derivative as an insecticide or an animal parasite control agent.
[001 1] In the present invention, "Cx.y" is an abbreviation that means the number of carbon atoms in a substituent within the range of x to y.
[0012] The present invention provides an oxadiazolinone derivative that has high activity and is suitable for use in pest control.
[0013] In an oxadiazolinone derivative of the present invention, examples of CM2 alkyl include linear or branched alkyl groups such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-
butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl and n-dodecyl.
Particularly, for example, linear or branched alkyl groups having 1 to 6 carbon atoms (Ci_6 alkyl) such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n-pentyl and n-hexyl are preferable.
[0014] A heteroatom means an atom other than a carbon atom, and examples thereof include hydrogen, oxygen, sulfur, nitrogen and phosphorus.
[0015] Examples of CM2 haloalkyi include linear or branched haloalkyi such as CH2F, CHF2, CF3, CF2CI, CFCI2, CF2Br, CF2CF3, CFHCF3, CH2CF3, CFCICF3, CCI2CF3, CF2CH3, CF2CH2F, CF2CHF2, CF2CF2CI, CF2CF2Br, CFHCH3, CFHCHF2, CHFCF3, CHFCF2CI, CHFCF2Br, CFCICF3, CCI2CF3, CF2CF2CF3, CH2CF2CF3, CF2CH2CF3, CF2CF2CH3, CHFCF2CF3,
CF2CHFCF3, CF2CF2CHF2, CF2CF2CH2F, CF2CF2CF2CI, CF2CF2CF2Br, CH(CF3)CF3,
CF(CF3)CF3, CF(CF3)CF2Br, CF2CF2CF2CF3, CH(CF3)CF2CF3 and CF(CF3)CF2CF3. Of them, Ci-6 haloalkyi is preferable. Each of these CM2 haloalkyi and Ci_6 haloalkyi groups also includes perfluoroalkyi in which all replaceable hydrogen atoms on the corresponding alkyl have been substituted by fluorine. The haloalkyi may further be substituted by an optional substituent.
[0016] Examples of CM2 alkoxy include linear or branched alkoxy such as methoxy, ethoxy, n- propoxy, i-propoxy, n-, iso-, sec- or tert-butoxy, pentyloxy and hexyloxy. Ci_6 alkoxy is preferable. These alkoxy groups may further be substituted by a substituent.
[0017] Examples of halogen include fluorine, chlorine, bromine and iodine. Fluorine, chlorine and bromine are preferable.
[0018] Examples of C3.8 cycloalkyl include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
[0019] Examples of C2_i2 alkenyl include vinyl, allyl, 1-propenyl, 1- (or 2- or 3-)butenyl and 1- pentenyl. C2.4 alkenyl is more preferable.
[0020] Examples of C2_i2 alkynyl include ethynyl, propargyl, 1-propynyl, but-3-ynyl and pent-4- ynyl. C2.4 alkynyl is more preferable.
[0021] Aryl is preferably a C6-i2 aromatic hydrocarbon group, and examples thereof include phenyl, naphthyl, and biphenyl. C6-io aromatic hydrocarbon groups are preferable, and C6 aromatic hydrocarbon groups are more preferable.
[0022] Specific examples of a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms can include: saturated rings such as pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, aziridinyl, oxiranyl, thiiranyl, azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl and tetrahydrothiopyranyl; partially saturated rings such as dihydropyrrolyl, dihydroisoxazolyl, dihydropyrazolyl, dihydrooxazolyl and dihydrothiazolyl; and furyl, thienyl, pyrrolyl, isoxazolyl, pyrazolyl, oxazolyl, isothiazolyl, thiazolyl, imidazolyl, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, indolyl, benzoxazolyl, benzothiazolyl and quinolyl. These heterocyclic rings may further be substituted by substituent.
[0023] The substituent in the phrase "may be substituted by an optional substituent" refers to, for example, amino, hydroxy, oxo, thioxo, halogen, nitro, cyano, isocyano, mercapto, isothiocyanato, carboxy, carboxamido, SF5, aminosulfonyl, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, monoalkylamino, dialkylamino, N-alkylcarbonyl-amino, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, aryloxycarbonyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, arylcarbonyl, alkylthio, cycloalkylthio, alkenylthio, cycloalkenylthio, alkynylthio, alkylsulfenyl, alkylsulfinyl, alkylsulfinyl including its isomers, alkylsulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylphosphinyl, alkylphosphonyl, alkylphosphinyl including its isomers, alkylphosphonyl including its isomers, N-alkyl-aminocarbonyl, Ν,Ν-dialkyl-aminocarbonyl, N- alkylcarbonyl-aminocarbonyl, N-alkylcarbonyl-N-alkylaminocarbonyl, aryl, aryloxy, benzyl, benzyloxy, benzylthio, arylthio, arylamino, benzylamino, a heterocyclic ring, trialkylsilyl, alkoxyalkyl, alkylthioalkyl, alkylthioalkoxy, alkoxyalkoxy, phenethyl, benzyloxy, haloalkyl, haloalkoxy, haloalkylthio, haloalkylcarbonyl, haloalkoxycarbonyl, haloalkoxyalkoxy,
haloalkoxyalkylthio, haloalkoxyalkylcarbonyl or haloalkoxyalkyi and preferably refers to chloro, fluoro, bromo, iodo, amino, nitro, cyano, hydroxy, thio or carboxy.
[0024] Preferable subgroups of the oxadiazolinone derivative of the formula (I) according to the present invention are listed below.
1) an oxadiazolinone derivative wherein G is a 6-membered heterocyclic ring comprising, as constituent atoms, at least one nitrogen atom and at least one heteroatom selected from the group consisting of nitrogen, sulfur and oxygen. In this case, G is more preferably a 6-membered heterocyclic ring comprising at least two nitrogen atoms as constituent atoms, even more preferably a 6-membered heterocyclic ring comprising two nitrogen atoms and four carbon atoms as constituent atoms. Particularly, when G is a 6- membered heterocyclic ring comprising two nitrogen atoms and four carbon atoms as constituent atoms, it is preferred that the positions of the two nitrogen atoms should be ortho
and para positions, respectively, relative to the site bonded to the oxadiazolinone ring and should also be ortho positions, relative to the site bonded to R1. It is the most desirable that one of the two nitrogen atoms should be flanked by the site bonded to R1 and the site bonded to the oxadiazolinone ring and the other nitrogen atom should be positioned at para position relative to the site bonded to the oxadiazolinone ring and simultaneously at ortho position relative to the site bonded to R1 , wherein R1 is positioned at para position relative to the site bonded to the oxadiazolinone ring.
(2) an oxadiazolinone derivative wherein G is a 5-membered heterocyclic ring comprising at least one nitrogen atom and, optionally, additional heteroatom(s) as constituent atoms. In this case, G is more desirably a 5-membered heterocyclic ring comprising one or two nitrogen atoms as constituent atoms and even more desirably comprises one nitrogen atom and four carbon atoms as constituent atoms or two nitrogen atoms and three carbon atoms as constituent atoms.
(3) an oxadiazolinone derivative wherein R1 is CM2 haloalkyl, CM2 haloalkoxy, CM2 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylamino, (phenyl)(Ci_i2 alkyl)amino, phenyl-Ci-i2 alkoxy, CM2 haloalkylsulfenyl or CM2 alkylsulfenyl-Ci_i2 alkyl, and these substituents may be substituted by a substituent selected from halogen, cyano, CM2 haloalkyl, Ci-12 alkylsulfenyl-Ci-12 alkyl and CM2 haloalkoxy.
(4) an oxadiazolinone derivative represented by the formula (I) wherein a moiety represented by the following formula:
R1
I
wherein a bond marked with an asterisk (*) binds to a carbon atom marked with an asterisk (*) in the following formula:
wherein R1 and R3 are as defined above; and each ring of G1 to G21 may further be substituted by an optional substituent.
[0025] In one embodiment, the following groups 1 to 9 of novel oxadiazolinone derivatives are preferable, and they are understood to be the subgroups of the compound represented by the above formula (I) in any of the following groups:
Group 1 : Group 2:
wherein R1 and R2 are as defined above
wherein R1 and R2 are as defined above;
Group 3: Group 4:
wherein R1 and R2 are as defined above; wherein R1 , R2, and R3 are as defined above; Group 5: Group 6:
wherein R1 , R2, and R3 are as defined above; wherein R1 , R2, and R3 are as defined above; Group 7: Group 8:
Group 9:
[0026] In another embodiment, R1 of compounds of formula (I) refers to a substituent comprising a halosubstituted Ci-i2alkyl group, e.g. CM2 haloalkyl; CM2 haloalkoxy; with CM2 haloalkyl, CM2 haloalkoxy, C2_i2 haloalkenyloxy and/or C2_i2 haloalkynyloxy substituted phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_i2
alkyl)amino, phenyl-Ci-i2 alkoxy, phenyl-Ci-i2 alkylsulfenyl, phenyl-Ci-i2 alkylsulfinyl, phenyl-Ci. 12 alkylsulfonyl or phenyl-Ci-i2 alkylamino; CM2 haloalkylsulfenyl; CM2 haloalkylsulfinyl; CM2 haloalkylsulfonyl; C2_i2 haloalkenyloxy; or C2_i2 haloalkynyloxy.
[0027] In yet another embodiment, R1 is a substituent selected from the group consisting of Ci. 12 haloalkyl; CM2 haloalkoxy; with CM2 haloalkyl, CM2 haloalkoxy substituted phenyl, phenoxy or pyridyl.
[0028] In yet another embodiment, R1 represents a substituent comprising a fluorosubstituted Ci_i2alkyl group of any of the substituents described in paragraphs [0027] and [0026].
[0029] In another embodiment, R2 represents H or Ci_i2alkyl such as methyl.
[0030] Subsequently, a process for producing the oxadiazolinone derivative of the formula (I) of the present invention is described. The process for producing the oxadiazolinone derivative of the formula (I) is not particularly limited, and specifically, the oxadiazolinone derivative of the formula (I) can be produced by the following Production Process (A), (B) or (Β'):
Production Process (A):
[0031] This process comprises: <Step A-1 >
reacting a compound represented by the formula (lnt-1):
R
{ lnt-1)
CN
wherein R1 and G are as defined above
with a hydroxyamine reagent, if necessary in the presence of an appropriate diluent and/or base to form a carboximidamide intermediate represented by the formula (lnt-2):
wherein R1 and G are as defined above; subsequently
<Step A-2>
reacting the carboximidamide intermediate with a carbonylating agent, if necessary in the presence of an appropriate diluent and/or base to prepare a compound represented by the formula (1-10):
wherein R1 and G are as defined above
included in the compound of the present invention wherein R2 represents hydrogen; and <Step A-3>
reacting the obtained compound with a compound represented by the following formula (r-1):
R2— L ( r-1)
wherein R2 is as defined above, and L1 represents a leaving group, for example, halogen, e.g., chlorine, bromine and fluorine or an alkylsulfonyl or arylsulfonyl group, e.g., methanesulfonyl, trifluoromethanesulfonyl, p-toluenesulfonyl and p-trifluoromethanephenylsulfonyl,
if necessary in the presence of an appropriate diluent and/or base to produce a compound represented by the formula (1-1 1) included in the compounds of the present invention:
wherein R1 and G are as defined above, and R2' is as defined in R2 with the proviso that hydrogen is not included.
[0032] Each step of Production Process (A) can be performed in accordance with a usual organic synthesis process.
[0033] Examples of the hydroxyamine reagent in <Step A-1 > can include hydroxyamine hydrochloride, hydroxyamine sulfate, and aqueous hydroxyamine solutions.
[0034] The reaction of <Step A-1 > can be carried out in an appropriate diluent, and examples of the diluent used therein can include aliphatic hydrocarbons (hexane, cyclohexane, heptane, etc.), aliphatic halogenated hydrocarbons (dichloromethane, chloroform, carbon tetrachloride,
dichloroethane, etc.), aromatic hydrocarbons (benzene, toluene, xylene, chlorobenzene, etc.), ethers (diethyl ether, dibutyl ether, dimethoxyethane (DME), tetrahydrofuran, dioxane, etc.), esters (ethyl acetate, ethyl propionate, etc.), acid amides (dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, etc.), nitriles (acetonitrile, propionitrile, etc.), dimethyl sulfoxide (DMSO), alcohols (methanol, ethanol, propanol, etc.), water, and mixed solvents thereof. Alcohols are desirable.
[0035] Examples of the appropriate base in <Step A-1 > can include: alkali metal bases such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium
hydrogencarbonate, sodium acetate, potassium acetate, sodium methoxide, sodium ethoxide and potassium-tert-butoxide; and organic bases such as triethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine, N,N-dimethylaniline, Ν,Ν-diethylaniline, 4-tert-butyl-N,N- dimethylaniline, pyridine, picoline, lutidine, diazabicycloundecene (DBU), diazabicyclooctane and imidazole.
[0036] <Step A-1 > can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably 0 and approximately 120°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 0.1 to 48 hours, preferably 2 to 24 hours.
[0037] In carrying out <Step A-1 >, for example, a hydroxyamine reagent, e.g., hydroxylamine hydrochloride in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-1) is reacted in a diluent, for example, ethanol, to obtain the corresponding compound of the formula (lnt-2).
[0038] Examples of novel compounds of the formula (lnt-1) used as a raw material in
Production Process (A) include 4-(pentafluoroethyl)pyrimidine-2-carbonitrile, 4-[2- (trifluoromethyl)phenyl]pyrimidine-2-carbonitrile, 4-[3-(trifluoromethyl)phenyl]pyrimidine-2- carbonitrile, 4-[4-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile, 6-(trifluoromethyl)-pyrimidine- 4-carbonitrile, 4-[2-(trifluoromethyl)phenoxy]pyrimidine-2-carbonitrile and 4-[4- (trifluoromethyl)phenoxy]pyrimidine-2-carbonitrile.
[0039] Examples of novel compounds of the formula (lnt-2) used as a raw material in
Production Process (A) include N'-hydroxy-4-(trifluoromethyl)pyrimidine-2-carboximidamide, N'-hydroxy-6-(trifluoromethyl)pyrimidine-4-carboximidamide, N'-hydroxy-2- (trifluoromethyl)pyrimidine-4-carboximidamide, N'-hydroxy-4-[2- (trifluoromethyl)phenyl]pyrimidine-2-carboximidamide, N'-hydroxy-4-[3- (trifluoromethyl)phenyl]pyrimidine-2-carboximidamide, N'-hydroxy-4-[4-
(trifluoromethyl)phenyl]pyrimidine-2-carboximidarnide, N'-hydroxy-4-[2- (trifluoromethyl)phenoxy]pyrimidine-2-carboximidarTiide, N'-hydroxy-4-[3- (trifluoromethyl)phenoxy]pyrimidine-2-carboxirnidarTiide and N'-hydroxy-4-[4- (trifluoromethyl)phenoxy]pyrirnidine-2-carboxirnidarTiide.
[0040] Examples of the carbonylating agent in <Step A-2> of Production Process (A) can include carbonyldiimidazole, phenyl chlorocarbonate and phosgene.
[0041] The reaction of <Step A-2> of Production Process (A) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in <Step A-1 >. Tetrahydrofuran is desirable.
[0042] The reaction of <Step A-2> of Production Process (A) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in <Step A-1 >. Diazabicycloundecene (hereinafter, sometimes abbreviated to "DBU") is desirable.
[0043] <Step A-2> of Production Process (A) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 100°C, preferably 0 and approximately 50°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 1 to 30 hours, preferably 3 to 12 hours.
[0044] In carrying out <Step A-2> of Production Process (A), for example, a carbonylating agent, for example, carbonyldiimidazole in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-2) is reacted in a diluent, for example, tetrahydrofuran, and the obtained product is then reacted with a base, for example, DBU in an amount of 1 mol to 3 mol to obtain the corresponding compound of the formula (1-10).
[0045] The compound of the formula (1-10) in Production Process (A) is included in the compound (I) of the present invention. Examples thereof include 3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazolidin-5-one, 3-[6-(trifluoromethyl)pyrimidin-4-yl]- 1 ,2,4-oxadiazolidin-5-one and 3-[2-(trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazolidin-5-one.
[0046] The reaction of <Step A-3> of Production Process (A) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in <Step A-1 >. Dimethylformamide is desirable.
[0047] The reaction of <Step A-3> of Production Process (A) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in <Step A-1 >. Sodium hydride is desirable.
[0048] <Step A-3> of Production Process (A) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 200°C, preferably 20 and approximately 100°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 1 to 30 hours, preferably 3 to 15 hours.
[0049] In carrying out <Step A-3> of Production Process (A), for example, a compound of the formula (r-1), for example, iodomethyl benzoate in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (1-10) is reacted in the presence of a base, for example, sodium hydride in an amount of 1 mol to 2 mol in a diluent, for example, dimethylformamide, to obtain the corresponding compound of the formula (1-1 1).
[0050] The compound of the formula (1-1 1) in Production Process (A) is included in the compound (I) of the present invention. Examples thereof include 4-methyl-3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5(4H)-one, 4-methyl-3-[6- (trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5(4H)-one, and 4-methyl-3-[2- (trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5(4H)-one.
[0051] The compound of the formula (lnt-1) in Production Process (A) can be produced by Production Process (a), (b), (c), (d), (e), or (f).
Production Process (a):
[0052] This process comprises reacting a compound represented by the formula (a-1):
wherein R1 , L1 , and G are as defined above
with a cyanating agent, if necessary in the presence of an appropriate diluent and/or base. Production Process (b):
[0053] This process comprises:
<Step b-1 >
reacting a compound represented by the formula (b-1):
wherein R1 is as defined above, and R4 represents Ci.
with a compound represented by the formula (b-2):
wherein R5 represents Ci_4 alkyl,
if necessary in the presence of an appropriate diluent and/or base to form a compound represented by the following formula (b-3):
wherein R1 , R5 and G are as defined above; subsequently <Step b-2>
reacting the obtained compound with an oxidizing agent, if necessary in the presence of appropriate diluent to form a compound represented by the following formula (b-4):
(the compound of the formula (b-4) is included in the compound of the formula (a-1)); and <Step b-3>
reacting the obtained compound with a cyanating agent, if necessary in the presence of an appropriate diluent and/or base.
Production Process (c):
[0054] This process comprises reacting a compound represented by the formula (c-1):
L1
I (e-1)
CN
wherein L1 and G are as defined above
with a compound represented by the formula (c-2): x-R ( 0-2) wherein V represents S, O, or NH, and R6 represents phenyl, phenyl-Ci.3 alkyl, Ci_6 alkyl, Ci_6 haloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl or C2-6 haloalkynyl,
if necessary in the presence of an appropriate diluent and/or base.
Production Process (d): wherein G represents imidazole
[0055] A specific production process of the compound of the formula (lnt-1) is shown in Scheme 1.
Scheme 1
Step d-2
wherein in Step d-1 , a starting compound is reacted with an appropriate alkali metalizing reagent, for example, butyllithium at a temperature of -60°C or lower in an appropriate dehydrated diluent, for example, tetrahydrofuran, and then reacted with dimethylformamide to form aldehyde; and in Step d-2, the aldehyde can be made into a hydroxyimine form through reaction with hydroxyamine hydrochloride at a temperature between 0°C and 70°C in an appropriate diluent, for example, pyridine, and then reacted with acetic anhydride at a temperature between 80°C and 150°C to obtain the object compound.
Production Process (e): wherein G represents pyrazole
[0056] A specific production process of the compound of the formula (lnt-1) is shown in Scheme 2.
wherein in Step e-1 , a starting compound can be made into an acid chloride form through reaction with an appropriate halogenating agent, for example, oxalyl chloride in an appropriate diluent, for example, dichloromethane, and then reacted with ammonia water to form acid amide; and in Step e-2, the acid amide can be reacted with trifluoromethanesulfonic anhydride in the presence of an appropriate base, for example, triethylamine at a temperature between - 10°C and 30°C in an appropriate diluent, for example, dichloromethane to obtain the object compound.
Production Process (f): wherein G represents pyrazole
[0057] A specific production process of the compound of the formula (lnt-1) is shown in Scheme 3.
Scheme 3:
wherein in Step f-1 , a starting compound can be made into a 4,5-dihydropyrazole form through reaction in an appropriate diluent, for example, ethanol; in Step f-2, the 4,5-dihydropyrazole form is heat-refluxed in the presence of an appropriate acid catalyst, for example, hydrochloric acid and dehydrated to prepare a pyrazole form; in Step f-3, the pyrazole form is oxidized with an appropriate oxidizing agent, for example, potassium permanganate at a temperature between 10°C and 80°C in an appropriate diluent, for example, a water-acetone mixed solvent to prepare a carboxylic acid form; and in Steps f-4 and f-5, reaction can be performed in the same ways as in Steps b-1 and b-2, respectively, to obtain the object compound.
[0058] Production processes (a), (b), (c), (d),(e), and (f) can be performed in accordance with a usual organic synthesis process.
[0059] Examples of the cyanating agent in Production Process (a) can include sodium cyanide, potassium cyanide, copper cyanide and zinc cyanide.
[0060] The reaction of Production Process (a) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Dimethyl sulfoxide is desirable.
[0061] Production Process (a) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably 0 and approximately 100°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 0.1 to 48 hours, preferably 3 to 24 hours.
[0062] In carrying out Production Process (a), for example, a cyanating agent, for example, sodium cyanide, in an amount of 1 mol to 2 mol with respect to 1 mol of the compound of the formula (a-1) is reacted in a diluent, for example, DMSO, to obtain the corresponding compound of the formula (lnt-1).
[0063] Examples of the compound of the formula (a-1) in Production Process (a) include 2- chloro-4-(trifluoromethyl)pyrimidine, 4-chloro-6-(trifluoromethyl)pyrimidine, 4-chloro-2- (trifluoromethyl)pyrimidine, 2-(methylsulfonyl)-4-[2-(trifluoromethyl)phenyl]pyrimidine, 2- (methylsulfonyl)-4-[3-(trifluoromethyl)phenyl]pyrimidine and 2-(methylsulfonyl)-4-[4- (trifluoromethyl)phenyl]pyrimidine.
[0064] The compound of the formula (a-1) can be produced, for example, by halogenating or sulfonating a compound of the following formula (a-1-1):
R1
I ( a -1 -1)
OH
in accordance with a usual organic chemical synthesis process.
[0065] Examples of the compound of the formula (a-1-1) include 4-hydroxy-6- (trifluoromethyl)pyrimidine and 4-hydroxy-2-(trifluoromethyl)pyrimidine.
[0066] The reaction of <Step b-1 > of Production Process (b) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Water is desirable.
[0067] The reaction of <Step b-1 > of Production Process (b) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Pyridine is desirable.
[0068] <Step b-1 > of Production Process (b) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 200°C, preferably 10 and approximately 120°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 1 to 100 hours, preferably 10 to 50 hours.
[0069] In carrying out <Step b-1 > of Production Process (b), for example, a compound of the formula (b-2), for example, S-methylisothiourea sulfate in an amount of 0.5 mol to 2 mol with respect to 1 mol of the compound of the formula (b-1) is reacted in the presence of pyridine as a base in a diluent, for example, water, to obtain the corresponding compound of the formula (b-3).
[0070] Examples of the compound of the formula (b-1) in Production Process (b) include (1 E)- 1-methoxy-4,4,5,5,5-pentafluoropent-1-en-3-one and (1 E)-1-ethoxy-4, 4,5,5, 5-pentafluoropent- 1-en-3-one.
[0071] Examples of the compound of the formula (b-2) in Production Process (b) include methylisothiourea sulfate and S-ethylisothiourea hydrobromide.
[0072] Examples of the compound of the formula (b-3) in Production Process (b) include 2- (methylsulfanyl)-4-(pentafluoroethyl)pyrimidine.
[0073] The reaction of <Step b-2> of Production Process (b) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified for Production Process (A). Dichloromethane is desirable.
[0074] Examples of the appropriate oxidizing agent in <Step b-2> of Production Process (b) include chromic acid, pyridium chromate, periodic acid, manganese dioxide, potassium permanganate and m-chloroperoxybenzoic acid (MCPBA). MCPBA is desirable.
[0075] <Step b-2> of Production Process (b) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 60 and approximately 100°C, preferably between approximately -20 and approximately 50°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure.
[0076] In carrying out <Step b-2> of Production Process (b), for example, an oxidizing agent, for example, MCPBA in an amount of 2 mol to 4 mol with respect to 1 mol of the compound of the formula (b-3) is reacted in a diluent, for example, dichloromethane, to obtain a compound of the formula (b-4).
[0077] Examples of the compound of the formula (b-4) in Production Process (b) include 2- (methylsulfonyl)-4-(pentafluoroethyl)pyrimidine.
[0078] The reaction conditions of <Step b-3> of Production Process (b) can be the same as those of Production Process (a).
[0079] The reaction of Production Process (c) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Dimethylformamide is desirable.
[0080] The reaction of Production Process (c) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Sodium hydride is desirable.
[0081] Production Process (c) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 200°C, preferably between 0 and approximately 100°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 0.1 to 24 hours, preferably 1 to 5 hours.
[0082] In carrying out Production Process (c), for example, a compound of the formula (e-2) in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (c-1) is reacted in the presence of sodium hydride as a base in a diluent, for example, DMF, to obtain the corresponding compound of the formula (lnt-1).
[0083] Examples of the compound of the formula (c-1) in Production Process (c) include 2- chloropyrimidine-4-carbonitrile. Examples of the compound of the formula (c-2) in Production Process (c) include 2,2,2-trifluoroethanethiol.
[0084] The compound of the formula (b-3) in Production Process (b) can be produced by Production Process (g) or (h) shown below.
Production Process (g):
[0085] This process comprises:
<Step g-1 >
wherein L1 and R5 are as defined above
with a compound represented by the formula (g-2):
R— B(OH)2 (g-2) wherein R1 is as defined above,
if necessary in the presence of an appropriate diluent, catalyst and/or base to form a com ound represented by the following formula (b-3):
wherein R1 , R5, and G are as defined above.
Production Process(h):
[0086] This process comprises reacting a compound represented by the formula (g-1):
wherein L1 , G, and R5 are as defined above
wherein V represents O or NH, and R6 is as defined above,
if necessary in the presence of an appropriate diluent and/or base.
[0087] The reaction of Production Process (g) can be performed in accordance with the process disclosed in WO2004/762. The reaction of Production Process (g) can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Dimethoxyethane and water are desirable.
[0088] The reaction of Production Process (g) can be carried out in the presence of an appropriate catalyst, and examples of the catalyst used therein include
tetrakis(triphenylphosphine)palladium and dichlorobis(triphenylphosphine)palladium.
Tetrakis(triphenylphosphine)palladium is desirable.
[0089] The reaction of Production Process (g) can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). Potassium carbonate is desirable.
[0090] The reaction of Production Process (g) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately - 20 and approximately 250°C, preferably between 50 and approximately 150°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 0.1 to 24 hours, preferably 1 to 5 hours.
[0091] In carrying out Production Process (g), for example, a compound of the formula (g-2) in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (g-1) is reacted in the presence of tetrakis(triphenylphosphine)palladium as a catalyst and potassium carbonate as a base in a diluent, for example, dimethoxyethane and water, to obtain the corresponding compound of the formula (b-3).
[0092] The reaction conditions of Production Process (h) can be the same as those of
Production Process (b). Examples of the compound of the formula (g-1) in Production Process (h) include 4-chloro-2-(methylsulfanyl)pyrimidine.
[0093] Examples of the compound of the formula (h-1) in Production Process (h) include 2,2,2- trifluoroethanol.
Production Process (B): wherein X in the formula (I) represents sulfur
[0094] This process comprises reacting a compound represented by the formula (1-12):
wherein R1 , R2, and G are as defined above
with a sulfurizing agent, if necessary in the presence of an appropriate diluent to produce a compound represented by the formula (1-13):
wherein R1 , R2, and G are as defined above
included in the compound of the present invention.
Production Process (Β'): wherein X in the formula (I) represents sulfur
[0095] This process comprises reacting a carboximidamide intermediate represented by the formula (lnt-2):
wherein R1 and G are as defined above
with a thiocarbonylating agent to produce a compound represented by the formula (1-13):
wherein R1 , R2, and G are as defined above
included in the compound of the present invention wherein R2 represents hydrogen.
[0096] Examples of the sulfurizing agent used in Production Process (B) can include diphosphorus pentasulfide and Lawesson's reagents.
[0097] The reaction of Production Process (B) can be carried out in an appropriate diluent, and examples of the diluent used therein can include the same as those exemplified in Production Process (A), preferably toluene.
[0098] The reaction of Production Process (B) can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately 0 and approximately 200°C, preferably between 20 and approximately 150°C. The reaction is
desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 1 to 20 hours, preferably 3 to 10 hours.
[0099] In carrying out Production Process (B), for example, a Lawesson's reagent in an amount of 0.5 mol to 3 mol with respect to 1 mol of the compound of the formula (1-12) is reacted in an appropriate diluent, for example, toluene, to obtain a compound of the formula (I- 13).
[0100] Examples of the thiocarbonylating agent in Production Process (Β') can include thiocarbonyldiimidazole and thiophosgene.
[0101] The reaction of Production Process (Β') can be carried out in an appropriate diluent, and examples of the diluent used therein include the same as those exemplified in Production Process (A). Tetrahydrofuran is desirable.
[0102] The reaction of Production Process (Β') can be carried out in the presence of an appropriate base, and examples of the base used therein include the same as those exemplified in Production Process (A). DBU is desirable.
[0103] Production Process (Β') can be carried out within a substantially wide temperature range. In general, it can be carried out at a temperature between approximately -20 and approximately 100°C, preferably between 0 and approximately 50°C. The reaction is desirably performed under normal pressure and can also be manipulated under pressure or under reduced pressure. The reaction time is 1 to 30 hours, preferably 3 to 12 hours.
[0104] In carrying out Production Process (Β'), for example, a thiocarbonylating agent, for example, thiocarbonyldiimidazole in an amount of 1 mol to 3 mol with respect to 1 mol of the compound of the formula (lnt-2) is reacted in a diluent, for example, tetrahydrofuran, and then the obtained product is reacted with a base, for example, DBU, in an amount of 1 mol to 3 mol to obtain the corresponding compound of the formula (1-13).
[0105] The compound of the formula (1-13) in Production Process (Β') is included in the compound (I) of the present invention. Examples thereof include 3-[4- (trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazole-5(4H)-thione.
[0106] The oxadiazolinone derivative of the present invention usually exhibits potent insecticidal effect and can be used as an insecticide. Furthermore, the oxadiazolinone derivative of the present invention usually exhibits potent disinfesting effect on harmful insects with no or little harmful adverse drug side effect to cultivated plants. Thus, the oxadiazolinone derivative of the present invention can be used for disinfesting a wide range of pest species,
for example, harmful sucking insects, chewing insects, and other plant-parasitic pests, stored product insects, and hygiene pests, and can be applied for the purpose of disinfesting or exterminating them. Examples of the harmful pests include the following:
[0107] As for insects, coleopterans such as Callosobruchus chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus and Aulacophora femoralis; lepidopterans such as Lymantria dispar, Malacosoma neustria, Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis, Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotisfucosa, Galleria mellonella, Plutella maculipennis, Heliothis virescens, and Phyllocnistis citrella; hemipterans such as Nephotettix cincticeps, Nilaparvata lugens,
Pseudococcus comstocki, Unapsis yanonensis, Myzus persicas, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nezara spp., Trialeurodes vaporariorm and Psylla spp.; thysanopterans such as Thrips palmi and Franklinella occidental; orthopterans such as Blatella germanica, Periplaneta americana, Gryllotalpa Africana and Locusta migratoria migratoriodes; isopterans such as Reticulitermes speratus and Coptotermes formosanus; dipterans such as Musca domestica, Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles sinensis, Culex tritaeniorhynchus, Liriomyza torifolii.
[0108] As for the order Acari, for example, Tetranychus cinnabarinus, Tetranychus urticae, Panonychus citri, Aculops pelekassi and Tarsonemus spp.
[0109] As for nematodes, for example, Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et Kiyohara, Aphelenchoides besseyi, Heterodera glycines, and Pratylenchus spp.
[0110] Furthermore, the oxadiazolinone derivative of the present invention shows excellent plant tolerance and preferable toxicity to warm-blooded animals and is well tolerated by the environment, and thus is suitable for protecting plants and plant parts.
[011 1] The application of the oxadiazolinone derivative of the present invention can bring about increased harvest yields and improved quality of harvested materials. The compound is further suitable for disinfesting harmful pests, particularly, insects, arachnids, helminths, nematodes and mollusks, which are encountered in the protection of stored products and the protection of materials, in the hygiene field, agriculture, horticulture or the veterinary field and in forests, gardens or recreational facilities. The compound of the present invention can be used preferably as a plant protectant. The oxadiazolinone derivative of the present invention has activity against normally sensitive or resistant species and against all or some of stages of growth. The above pests particularly include the following:
[0112] From the order Anoplura (Phthiraptera), for example, Damalinia spp., Haematopinus, Linognathus spp., Pediculus spp. and Trichodectes spp.
[0113] From the class Arachnida, for example, Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranyctus spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Oligonychus spp., Ornithodoros spp.,
Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp. and Vasates lycopersici.
[0114] From the class Bivalvia, for example, Dreissena spp.
[0115] From the order Chilopoda, for example, Geophilus spp. and Scutigera spp.
[0116] From the order Coleoptera, for example, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Ceuthorhynchus spp., Cleonus mendicus, Conoderus spp.,
Cosmopolites spp., Costelytra zealandica, Curculio spp., Cryptorhynchus lapathi, Dermestes spp., Diabrotica spp., Epilachna spp., Faustinus cubae, Gibbium psylloides, Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha, Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Popillia japonica, Premnotrypes spp., Psylliodes chrysocephala, Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp.,
Xylotrechus spp. and Zabrus spp.
[0117] From the order Collembola, for example, Onychiurus armatus.
[0118] From the order Dermaptera, for example, Forficula auricularia.
[0119] From the order Diplopoda, for example, Blaniulus guttulatus.
[0120] From the order Diptera, for example, Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chrysomyia spp., Cochliomyia spp., Cordylobia
anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dermatobia hominis, Drosophila spp., Fannia spp., Gastrophilus spp., Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Stomoxys spp., Tabanus spp., Tannia spp., Tipula paludosa and Wohlfahrtia spp.
[0121] From the class Gastropoda, for example, Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp. and Succinea spp.
[0122] From the class of helminths, for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus
medeinensis, Echinococcus granulosus, Echinococcus multiocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni,
Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria and Wuchereria bancrofti.
[0123] The compound of the present invention can further disinfest protozoans such as Eimeria.
[0124] From the order Heteroptera, for example, Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus.spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horchias nobiellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodonius spp., Sahlbergella singularis, Scotinophora spp., Stephanitis nashi, Tibraca spp. and Triatoma spp.
[0125] From the order Homoptera, for example, Acyrthosipon spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus,
Cicadulina mbila, Coccomytilus halli, Coccus spp., Chryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Doralis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Geococcus coffeae, Homalodisca coagulata, Hyalopterus arundinis, lcerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratorioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesda gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus,
Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp., Typhlocyba spp., Unaspis spp. and Viteus vitifolii.
[0126] From the order Hymenoptera, for example, Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis and Vespa spp.
[0127] From the order Isopoda, for example, Armadillidium vulgare, Oniscus asellus and Porcellio scaber.
[0128] From the order Isoptera, for example, Reticulitermes spp. and Odontotermes spp.
[0129] From the order Lepidoptera, for example, Acronicta major, Aedia leucomelas, Agrotis spp., Alabama argillacea, Anticarsia spp., Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Cheimatobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp., Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa spp., Feltia spp., Galleria mellonella, Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma spp., Lithocolletis blancardella, Lithophane antennata, Loxagrotis albicosta, Lymantria spp., Malacosoma neustria, Mamestra brassicae, Mods repanda, Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, Pectinophora gossypiella, Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Spodoptera spp., Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana and Trichoplusia spp.
[0130] From the order Orthoptera, for example, Acheta domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana and Schistocerca gregaria.
[0131] From the order Siphonaptera, for example, Ceratophyllus spp. and Xenopsylla cheopis.
[0132] From the order Symphyla, for example, Scutigerella immaculata.
[0133] From the order Thynsanoptera, for example, Baliothrips biformis, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Kakothrips spp.,
Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni and Thrips spp.
[0134] From the order Thysanura, for example, Lepisma saccharina.
[0135] Examples of phytoparasitic nematodes include Anguina spp., Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp.,
Heliocotylenchus spp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp., Tylenchorhynchus spp., Tylenchulus spp., Thlenchulus semipenetrans and Xiphinema spp.
[0136] According to the present invention, every plant and every part of plants can be treated. In the present invention, it should be understood that the plants mean all plants and plant populations such as desirable or undesirable wild plants or grain plants (including naturally growing grain plants). The grain plants can be plants that can be obtained by routine plant breeding and optimization methods, by biotechnological and genetic engineering methods or by combinations of these methods. These grain plants include transgenic plants and encompass plant varieties that may or may not be protected by plant breeders' rights. It should be understood that the parts of plants mean every part or organ of plants above or below the ground, such as buds, leaves, flowers, and roots. Examples thereof can also include leaves, needles, stems, trunks, flowers, fruit bodies, fruits, seeds, roots, tubers and subterranean stems. The parts of plants also include collected substances, and vegetatively or reproductively propagating substances, for example, cuttings, tubers, subterranean stems, lateral braches and seeds.
[0137] The treatment of the plants or the parts of plants with the active compound according to the present invention is carried out either directly or by allowing the compound to act on the surroundings, habitats or storage areas of the plants or the parts of plants by routine treatment methods, for example, dipping, spraying, vaporization, atomization, scattering, application and
injection, or for propagating substances particularly for seeds, by application of one or more coatings.
[0138] The compound of the present invention exhibits permeable effect, which means that the compound is capable of penetrating through a plant body and moving in the parts of plants from under to above the ground.
[0139] As already described above, all plants and their parts can be treated according to the present invention. In a preferred embodiment, wild plant species and plant cultivars or those obtained by traditional biological breeding methods such as hybridization or protoplast fusion and the parts thereof are treated. In a further preferred embodiment, transgenic plants and plant varieties (genetically modified organisms) obtained by appropriate combinations of genetic engineering methods with conventional methods and the parts thereof are treated. The terms "parts" and "parts of plants" are as described above.
[0140] Particularly preferably, plants of varieties which are commercially available or in use are treated according to the present invention in each case. It is understood that the plant varieties mean plants with novel properties ("traits"), which are obtained by conventional breeding, mutagenesis or recombinant DNA techniques. They can be plant varieties, biotypes or genotypes.
[0141] The treatment according to the present invention can bring about superadditive ("synergistic") effects depending on plant species or plant varieties, their locations and propagation conditions (soil, climate, growth period, and nutrition). Thus, the treatment according to the present invention can probably result in, for example, reduced application rates and/or expanded activity spectra and/or increased activities of substances and compositions available according to the present invention, improved plant growth, increased tolerance to high or low temperatures, increased tolerance to droughts or to water or soil salt contents, improved flowering performance, simplified collection, accelerated maturation, increased harvest yields, improved quality and/or increased nutritional values of collected products, and improved storage stability and/or processability of collected products, which exceed actually expected effects.
[0142] The preferable transgenic plants or plant varieties (obtained by genetic engineering) treated in accordance with the present invention include all plants that have received, by means of genetic modification, genetic materials imparting exceedingly advantageous and useful traits to these plants. Examples of such properties include improved plant growth, increased tolerance to high or low temperatures, increased tolerance to droughts or to water or soil salt contents, improved flowering performance, simplified collection, accelerated
maturation, increased harvest yields, improved quality and/or increased nutritional values of collected products, and improved storage stability and/or processability of collected products. Examples where such traits are further and particularly emphasized include improved defense of plants against harmful pests and microorganisms such as insects, mites, phytopathogenic fungi, bacteria and/or viruses, and increased tolerance of plants to certain herbicidally active compounds. Examples of the transgenic plants can include: important grain plants such as grains (wheat and rice), maize, soy bean, potato, sugar beet, tomato, bean, and other vegetable cultivars, cotton, tobacco and rapeseed; and fruit plants such as those bearing fruits, for example, apples, pears, citrus fruits and grapes. Particularly, maize, soy bean, potato, cotton, tobacco and rapeseed are important. Traits that are emphasized are, particularly, increased defense of plants against insects, arachnids, nematodes, slugs and snails attributed to toxins formed in the plants, particularly, toxins formed in the plants by genetic materials derived from Bacillus thuringiensis (e.g., by genes CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2, Cry9c, Cry2Ab, Cry3Bb and CrylF, and combinations thereof) (hereinafter, referred to as "Bt plants"). Traits that are also particularly emphasized are increased defense of plants against fungi, bacteria, and viruses attributed to systemic acquired resistance (SAR), systemin, phytoalexin, elicitors, and resistance genes, and corresponding expressed proteins and toxins. Further traits that are particularly emphasized are increased tolerance of plants to certain herbicidally active compounds, for example, imidazolinone, sulfonylurea, glyphosate or phosphinotricin (e.g., "PTA" genes). Genes that impart the desired traits may be allowed to exist in combination with one another in the transgenic plants. Examples of the "Bt plants" can include maize, cotton, soy bean and potato cultivars sold under the trade names YIELD GARD(R) (e.g., maize, cotton and soy bean), KnockOut(R) (e.g., maize), Starl_ink(R) (e.g., maize), Bollgard(R) (cotton), Nucotn(R) (cotton) and NewLeaf(R) (potato). Examples of the plants tolerant to herbicides can include maize, cotton and soy bean cultivars sold under the trade names Roundup Ready(R) (tolerance to glyphosate; e.g., maize, cotton and soy beans), Liberty Link(R) (tolerance to phosphinotricin; e.g., rapeseed), IMI(R) (tolerance to imidazolinones) and STS(R) (tolerance to sulfonylurea; e.g., maize). Examples of the plants resistant to herbicides (plants bred by conventional manners for imparting herbicide resistance) include cultivars sold under the name Clearfield(R) (e.g., maize). Of course, these descriptions also hold true for plant varieties having these genetic traits or genetic traits to be developed in the future, and such plant varieties will be developed and/or marketed in the future.
[0143] The listed plants can be treated particularly advantageously with the oxadiazolinone derivative of the present invention at an appropriate concentration.
[0144] The novel compound of the present invention can further be used effectively against various harmful parasitic pests (entozoan and ectozoan), for example, insects and helminths,
in the veterinary field. Examples of such harmful parasitic pests include those described below. Examples of insects include Gasterophilus spp., Stomoxys spp., Trichodectes spp., Rhodonius spp., Ctenocephalides canis, Cimx lecturius, Ctenocephalides felis and Lucilia cuprina. Examples of acari include Ornithodoros spp., Ixodes spp. and Boophilus spp.
[0145] The active compound of the present invention is active against parasitic animals, particularly, ectoparasites or endoparasites, in the field of veterinary specialists, i.e., in the veterinary field. The term endoparasite particularly includes helminths such as cestodes, nematodes and trematodes, and protozoans such as Coccidia. The ectoparasites are typically and preferably arthropods, particularly, insects such as flies (biting and licking flies), parasitic fly larvae, lice, hair lice, bird lice and flea, or Acarina such as mites, for example, hard ticks, soft ticks, scab mites, harvest mites and bird mites.
[0146] These parasites include the following:
[0147] From the order Anoplurida, for example, Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp. and Solenopotes spp. Specific examples are Linognathus setosus, Linognathus vituli, Linognathus ovillus, Linognathus oviformis, Linognathus pedalis, Linognathus stenopsis, Haematopinus asini macrocephalus, Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus corporis, Phylloera vastatrix, Phthirus pubis and Solenopotes capillatus.
[0148] From the order Mallophagida and the suborders Amblycerina and Ischnocerina, for example, Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp. and Felicola spp. Specific examples are Bovicola bovis, Bovicola ovis, Bovicola limbata, Damalina bovis, Trichodectes canis, Felicola subrostratus, Bovicola caprae, Lepikentron ovis and Werneckiella equi.
[0149] From the order Diptera and the suborders Nematocerina and Brachycerina, for example, Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp.,
Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Odagmia spp., Wilhelmia spp., Hybomitora spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp., Rhinoestrus spp. and Tipula spp. Specific examples are Aedes aegypti, Aedes albopictus, Aedes taeniorhynchus, Anopheles gambiae, Anopheles maculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Fannia canicularis, Sarcophaga carnaria, Stomoxys calcitrans, Tipula
paludosa, Lucilia cuprina, Lucilia sericata, Simulium reptans, Phlebotomus papatasi,
Phlebotomus longipalpis, Odagmia ornata, Wilhelmia equina, Boophthora erythrocephala, Tabanus bromius, Tabanus spodopterus, Tabanus atratus, Tabanus sudeticus, Hybomitra ciurea, Chrysops caecutiens, Chrysops relictus, Haematopota pluvialis, Haematopota italica, Musca autumnalis, Musca domestica, Haematobia irritans irritans, Haematobia irritans exigua, Haematobia stimulans, Hydrotaea irritans, Hydrotaea albipuncta, Chrysomya chloropyga, Chrysomya bezziana, Oestrus ovis, Hypoderma bovis, Hypoderma lineatum, Przhevalskiana silenus, Dermatobia hominis, Melphagus ovinus, Lipoptena capreoli, Lipoptena cervi,
Hippobosca variegata, Hippobosca equina, Gasterophilus intestinalis, Gasterophilus haemorroidalis, Gasterophilus inermis, Gasterophilus nasalis, Gasterophilus nigricornis, Gasterophilus pecorum and Braulra coeca;
[0150] From the order Siphonapterida, for example, Pulex spp., Ctenocephalides spp., Tunga spp., Xenopsylla spp. and Ceratophyllus spp., and specific examples are
Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans and Xenopsylla cheopsis.
[0151] From the order Heteropterida, for example, Cimex spp., Triatoma spp., Rhodnius spp. and Panstrongylus spp.
[0152] From the order Blattarida, for example, Blatta orientalis, Periplaneta americana, Blattela germanica, and Supella spp. (e.g., Supella longipalpa).
[0153] From the subclass Acari (Acarina) and the orders Metastigmata and Mesostigmata, for example, Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Rhipicephalus (Boophilus) spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Dermanyssus spp., Rhipicephalus spp. (the original genus of multi-host ticks), Ornithonyssus spp., Pneumonyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp. and Acarapis spp. Specific examples are Argas persicus, Argas reflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus (Boophilus) microplus, Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) annulatus, Rhipicephalus (Boophilus) calceratus, Hyalomma annatolicum, Hyalomma aegypticum, Hyalomma marginatum, Hyalomma transiens, Rhipicephalus evertsi, Ixodes ricinus, Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna, Haemaphysalis punctata, Haemaphysalis cinnabarina, Haemaphysalis otophila,
Haemaphysalis leachi, Haemaphysalis longicorni, Dermacentor marginatus, Dermacentor reticulatus, Dermacentor pictus, Dermacentor albipictus, Dermacentor andersoni, Dermacentor variabilis, Hyalomma mauritanicum, Rhipicephalus sanguineus, Rhipicephalus bursa,
Rhipicephalus appendiculatus, Rhipicephalus capensis, Rhipicephalus turanicus,
Rhipicephalus zambeziensis, Amblyomma americanum, Amblyomma variegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyomma cajennense, Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssus sylviarum and Varroa jacobsoni;
[0154] From the orders Actinedida (Prostigmata) and Acaridida (Astigmata), for example, Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp.,
Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp. and Laminosioptes spp. Specific examples are Cheyletiella yasguri, Cheyletiella blakei, Demodex canis, Demodex bovis, Demodex ovis, Demodex caprae, Demodex equi, Demodex caballi, Demodex suis, Neotrombicula autumnalis, Neotrombicula desaleri, Neoschongastia xerothermobia, Trombicula akamushi, Otodectes cynotis, Notoedres cati, Sarcoptis canis, Sarcoptes bovis, Sarcoptes ovis, Sarcoptes rupicaprae (= S. caprae), Sarcoptes equi, Sarcoptes suis, Psoroptes ovis, Psoroptes cuniculi, Psoroptes equi, Chorioptes bovis, Psoergates ovis, Pneumonyssoidic mange, Pneumonyssoides caninum and Acarapis woodi.
[0155] The oxadiazolinone derivative of the present invention is also suitable for disinfesting arthropods, helminths and protozoans that attack animals. The animals include agricultural livestock such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, chickens, turkeys, ducks, geese, cultured fishes and honeybees. The animals further include, for example, pet animals (also referred to as companion animals) such as dogs, cats, cage birds and aquarium fishes, and animals known as experimental animals such as hamsters, guinea pigs, rats and mice.
[0156] The disinfestion of these arthropods, helminths, and/or protozoans is expected to reduce the mortality of animals and improve productivity (of meat, milk, wool, leather, eggs and honey, etc.) and the health of host animals. Thus, the use of the active compound of the present invention achieves the further economical and convenient raising of animals.
[0157] For example, it is desirable to suppress or interrupt the uptake of blood from hosts by parasites (when applicable). The disinfestion of parasites may also help suppress the transmittance of infectious agents.
[0158] The term "disinfest" used herein as to the veterinary field means that the active compound is effective in reducing the incidence of parasite in each animal infected with such a parasite to harmless levels. More specifically, the term "disinfest" used herein means that the active compound is effective in killing each parasite, inhibiting its growth or inhibiting its propagation.
[0159] In general, the oxadiazolinone derivative of the present invention, when used in the treatment of animals, can be applied directly. Preferably, the compound of the present invention is applied as pharmaceutical compositions which may contain pharmaceutically acceptable excipients and/or auxiliaries publicly known in the art.
[0160] In the veterinary field and in livestock raising, the active compound is applied (= administered) in a manner known in the art by enteral administration in the form of, for example, tablets, capsules, drinks, drenches, granules, pastes, boluses, methods via feed or suppositories or by parenteral administration such as injections (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.), implants or nasal application, for example, by dermal application in the form of dipping or immersion, spraying, pouring-on, spotting-on, washing or dusting or with the aid of active compound-containing molded articles such as collars, ear tags, tail tags, limb bands, halters and marking tools. The active compound may be formulated as shampoo, appropriate preparations available in aerosols or unpressurized sprays such as pump sprays and atomizer sprays.
[0161] The active compound of the present invention, when used for livestock, poultry, pet animals and the like, can be applied, either directly or after dilution (e.g., 100- to 10,000-fold dilution), as preparations (e.g., powders, wettable powders ["WP"], emulsions, emulsifiable concentrates ["EC"], flowables, homogeneous solutions and suspension concentrates ["SC"]) containing the active compound in an amount of 1 to 80% by weight (% by mass as an SI unit), or can be used as an immersion bath thereof.
[0162] The active compound of the present invention, when used in the veterinary field, may be used in combination with appropriate synergists or other active compounds, such as miticides, insecticides, anthelmintics and antiprotozoal drugs.
[0163] In the present invention, substances having insecticidal effect on pests including all of them are referred to as insecticides.
[0164] The active compound of the present invention can be prepared in conventional dosage forms, when used as an insecticide. Examples of the dosage forms include solutions, emulsions, wettable powders, water-dispersible granules, suspensions, powders, foams, pastes, tablets, granules, aerosols, active compound-impregnated natural and synthetic substances, microcapsules, seed coating agents, preparations used with a combustion apparatus (e.g., smoking or fuming cartridges, cans and coils as combustion apparatuses) and ULV (cold or warm mist).
[0165] These preparations can be produced by a process publicly known per se in the art. The preparations can be produced, for example, by mixing the active compound with a developer i.e., a liquid diluent or carrier, a liquefied gas diluent or carrier, or a solid diluent or carrier, and optionally with a surfactant i.e., an emulsifier and/or a dispersant and/or a foaming agent.
[0166] When water is used as the developer, for example, an organic solvent can also be used as an auxiliary solvent.
[0167] Examples of the liquid diluent or carrier include aromatic hydrocarbons (e.g., xylene, toluene and alkylnaphthalene), chlorinated aromatic or chlorinated aliphatic hydrocarbons (e.g., chlorobenzene, ethylene chloride and methylene chloride), aliphatic hydrocarbons (e.g., cyclohexane), paraffin (e.g., mineral oil fractions), alcohols (e.g., butanol or glycol and their ethers or esters), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone), strong polar solvents (e.g., dimethylformamide and dimethyl sulfoxide) and water.
[0168] The liquefied gas diluent or carrier can be, for example, those in a gas state at normal temperature and normal pressure, such as aerosol propellants including butane, propane, nitrogen gas, carbon dioxide and halogenated hydrocarbon.
[0169] Examples of the solid diluent include pulverized natural minerals (e.g., kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite and diatomaceous earth) and pulverized synthetic minerals (e.g., highly dispersed silicic acid, alumina and silicate).
[0170] Examples of the solid carrier for granules include pulverized and sieved rocks (e.g., calcite, marble, pumice, sepiolite, and dolomite), synthetic granules of inorganic or organic powder and fine particles of organic materials (e.g., sawdust, coconuts, corncobs and tobacco stems).
[0171] Examples of the emulsifier and/or the foaming agent include: nonionic or anionic emulsifiers such as polyoxyethylene fatty acid ester, polyoxyethylene fatty acid alcohol ether (e.g., alkylaryl polyglycol ether), alkylsulfonate, alkylsulfate and arylsulfonate; and albumin hydrolysates.
[0172] Examples of the dispersant include lignin-sulfite waste liquors and methylcellulose.
[0173] A fixative may also be used in the preparations (powders, granules or emulsions), and examples of the fixative include carboxymethylcellulose and natural or synthetic polymers (e.g., gum arabic, polyvinyl alcohol and polyvinyl acetate).
[0174] A colorant may also be used, and examples of the colorant include inorganic pigments (e.g., iron oxide, titanium oxide and Prussian Blue), organic dyes (e.g., alizarin dyes, azo dyes and metallophthalocyanine dyes), and further, trace elements such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts.
[0175] The preparations can generally contain the active ingredient in an amount ranging from 0.1 to 95% by weight, preferably 0.5 to 90% by weight.
[0176] The oxadiazolinone derivative of the present invention can also exist as mixtures with other active compounds, for example, insecticides, toxic feed, bactericides, miticides, nematicides, fungicides, growth regulators and herbicides, in their commercially useful preparation forms and in application forms prepared from these preparations.
[0177] The content of the compound of the present invention in a commercially useful application form can vary within a wide range.
[0178] The concentration of the active compound of the present invention in actual use can be, for example, in the range of 0.0000001 to 100% by weight, preferably 0.00001 to 1 % by weight.
[0179] The oxadiazolinone derivative of the present invention can be used through conventional methods suitable for usage patterns.
[0180] The oxadiazolinone derivative of the present invention has stability effective against alkali on lime materials when used against hygiene pests and pests infesting stored products, and also exhibits excellent residual effect on wood and soil.
[0181] The active compound of the present invention is also low toxic to warm-blooded animal and can be used safely.
Examples
[0182] Next, the present invention will be described further specifically on the basis of Examples. However, the present invention is not intended to be limited to them by any means.
Example 1 : Synthesis of 3-r4-(trifluoromethyl)pyrimidin-2-vn-1 ,2,4-oxadiazol-5-one
[0183] <Step 1-1 > Synthesis of N'-hydroxy-4-(trifluoromethyl)pyrimidine-2-carboxirnidarnide
[0184] Hydroxylamine hydrochloride (0.71 g) and sodium hydrogencarbonate (0.85 g) were heat-refluxed for 1 hour in ethanol and then cooled to 0°C, and an ethanol solution of 4- (trifluoromethyl)pyrimidine-2-carbonitrile (0.8 g) was dropped theron. The mixture was stirred at room temperature for 20 hours, and then, the solvent was concentrated. Water was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated and the residue was purified by silica gel column chromatography to obtain N'-hydroxy-4-(trifluoromethyl)pyrimidine-2- carboximidamide (0.73 g).
[0185] <Step 1-2> Synthesis of 3-[4-(trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5-one (G1-1)
[0186] N'-hydroxy-4-(trifluoromethyl)pyrimidine-2-carboximidamide (0.5 g) was dissolved in tetrahydrofuran and carbonyldiimidazole (0.43 g) was added thereto. The mixture was stirred at room temperature for 2 hours. Then, DBU (0.43 ml_) was added thereto, and the mixture was stirred at room temperature for 20 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. Then, the organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[4-(trifluoromethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5-one
(0.05 g).
Example 2: Synthesis of 3-r4-(pentafluoroethyl)pyrimidin-2-vn-1 ,2,4-oxadiazol-5-one (Compound No. G1 -2)
[0187] <Step 2-1 > Synthesis of 2-(methylsulfanyl)-4-(pentafluoroethyl)pyrimidine
[0188] 1-Ethoxy-4,4,5,5,5-pentafluoropent-1-en-3-one (6.5 g) and S-methylisothiourea sulfate (4.2 g) were dissolved in water (60 ml). Pyridine (3.5 g) was added thereto, and then, the mixture was heat-refluxed for 40 hours. The reaction mixture was subjected to extraction with ethyl acetate, and then, the organic layer was washed with 1 N hydrochloric acid and saturated saline and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 2-(methylsulfanyl)-4-(pentafluoroethyl)pyrimidine (1.45 g).
[0189] <Step 2-2> Synthesis of 2-(methylsulfonyl)-4-(pentafluoroethyl)pyrimidine
[0190] 2-(Methylsulfanyl)-4-(pentafluoroethyl)pyrimidine (1.45 g) was dissolved in dichloromethane. m-Chloroperbenzoic acid (3.7 g) was added thereto at 0°C, and the mixture was stirred at room temperature for 5 hours. An aqueous sodium thiosulfate solution and a saturated aqueous solution of sodium hydrogencarbonate were added thereto, and the mixture was stirred for 30 minutes. The organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 2-(methylsulfonyl)-4-(pentafluoroethyl)pyrimidine (1.47 g).
[0192] 2-(Methylsulfonyl)-4-(pentafluoroethyl)pyrimidine (0.7 g) was dissolved in dimethyl sulfoxide, and sodium cyanide (0.12 g) was added thereto at 10°C. The mixture was stirred at room temperature for 30 minutes, and then, water was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with saturated sodium hydrogencarbonate and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 4- (pentafluoroethyl)pyrimidine-2-carbonitrile (0.29 g).
[0193] <Step 2-4> Synthesis of N'-hydroxy-4-(pentafluoroethyl)pyrimidine-2- carboximidamide
[0194] An aqueous hydroxylamine solution (0.16 g) was added to an ethanolic solution of 4- (pentafluoroethyl)pyrimidine-2-carbonitrile (0.29 g), and the mixture was stirred at room temperature for 5 hours. Water was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was washed with t-butylmethyl ether to obtain N'- hydroxy-4-(pentafluoroethyl)pyrimidine-2-carboximidamide (0.28 g).
<Step 2-5> Synthesis of 3-[4-(pentafluoroethyl)pyrimidin-2-yl]-1 ,2,4-oxadiazol-5-
[0196] N'-Hydroxy-4-(pentafluoroethyl)pyrimidine-2-carboximidamide (0.2 g) was dissolved in tetrahydrofuran, and carbonyldiimidazole (0.14 g) was added thereto. The mixture was stirred at room temperature for 2 hours. Then, DBU (0.14 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto,
followed by extraction with ethyl acetate. Then, the organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated, and the precipitated crystal was filtered and washed with water and t-butylmethyl ether to obtain 3-[4-(pentafluoroethyl)pyrimidin-2-yl]- 1 ,2,4-oxadiazol-5-one (0.12 g).
Example 3: Synthesis of 3-r4-(2,2,2-trifluoroethoxy)pyrimidin-2-vni,2,4-oxadiazol-5(4H)- one (G1 -7)
[0197] <Step 3-1 > Synthesis of 4-(2,2,2-trifluoroethoxy)pyrimidine-2-carbonitrile
[0198] 2-(Methylsulfonyl)-4-(2,2,2-trifluoroethoxy)pyrimidine (0.8 g) was dissolved in dimethyl sulfoxide, and sodium cyanide (0.15 g) was added thereto at 10°C. The mixture was stirred at room temperature for 30 minutes, and then, water was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with saturated sodium hydrogencarbonate and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 4-(2,2,2- trifluoroethoxy)pyrimidine-2-carbonitrile (0.2 g).
[0199] <Step 3-2> Synthesis of N'-hydroxy-4-(2,2,2-trifluoroethoxy)pyrimidine-2- carboximidamide
[0200] An aqueous hydroxylamine solution (0.13 g) was added to an ethanolic solution of 4- (2,2,2-trifluoroethoxy)pyrimidine-2-carbonitrile (0.2 g), and the mixture was stirred at room temperature for 20 hours. Water was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate. The solvent
was concentrated, and then, the residue was washed with t-butylmethyl ether to obtain N'- hydroxy-4-(2,2,2-trifluoroethoxy)pyrirnidine-2-carboxirnidarTiide (0.22 g).
[0201] <Step 3-3> Synthesis of 3-[4-(2,2,2-trifluoroethoxy)pyrimidin-2-yl]1 ,2,4-oxadiazol- 5(4H)-one (G1-7)
[0202] N'-Hydroxy-4-(2,2,2-trifluoroethoxy)pyrirnidine-2-carboxirnidarTiide (0.22 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.17 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.17 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was washed with t-butylmethyl ether to obtain 3-[4-(2,2,2- trifluoroethoxy)pyrimidin-2-yl]1 ,2,4-oxadiazol-5(4H)-one (0.23 g).
Example 4: Synthesis of 3-r6-(trifluoromethyl)pyrimidin-4-vn-1 ,2,4-oxadiazol-5-one (G2- D
[0203] <Step 4-1 > Synthesis of 6-(trifluoromethyl)pyrimidine-4-carbonitrile
[0204] 4-Chloro-6-(trifluoromethyl)pyrimidine (0.98 g) and potassium cyanide (0.7 g) were added to acetonitrile, and the mixture was heat-refluxed for 20 hours. Insoluble matter was filtered off, and the solvent was distilled off. The residue was purified by silica gel column chromatography to obtain 6-(trifluoromethyl)pyrimidine-4-carbonitrile (0.18 g).
[0205] <Step 4-2> Synthesis of N'-hydroxy-6-(trifluoromethyl)pyrimidine-4-carboxirnidarTiicle
[0206] Hydroxylamine hydrochloride (0.16 g) and sodium hydrogencarbonate (0.2 g) were heat-refluxed for 1 hour in ethanol and then cooled to 0°C, and an ethanol solution of 6- (trifluoromethyl)pyrimidine-4-carbonitrile (0.18 g) was dropped thereon. The mixture was stirred at room temperature for 20 hours, and then, the solvent was concentrated. Water was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated to obtain N'-hydroxy-4- (trifluoromethyl)pyrimidine-2-carboximidamide (0.19 g).
[0207] <Step 4-3> Synthesis of N'-[(phenoxycarbonyl)oxy]-6-(trifluoromethyl)pyrimidine-4- carboximidamide
[0208] N'-Hydroxy-4-(trifluoromethyl)pyrimidine-2-carboximidamide (0.19 g) and
triethylamine (0.13 g) were dissolved in DMF, and phenyl chlorocarbonate (0.16 g) was added thereto at 0°C. The mixture was stirred at room temperature for 4 hours, and then, 5% saline was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with 5% saline and saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain N'-[(phenoxycarbonyl)oxy]-6-(trifluoromethyl)pyrimidine-4-carboximidamide (0.22 g).
[0210] N'-[(Phenoxycarbonyl)oxy]-6-(trifluoromethyl)pyrimidine-4-carboximidami (0.22 g) was dissolved in chlorobenzene, and the solution was irradiated with microwave at 180°C for 1.5 hours. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[6-(trifluoromethyl)pyrimidin-4-yl]-1 ,2,4-oxadiazol-5-one (0.04 g).
Example 5: Synthesis of 3-r2-(trifluoromethyl)pyrimidin-4-vni,2,4-oxadiazol-5(4H)-one
(G3-1 )
[021 1] <Step 5-1 > Synthesis of N'-hydroxy-2-(trifluoromethyl)pyrimidine-4-carboximidamide
[0212] An aqueous hydroxylamine solution (0.16 g) was added to an ethanolic solution of 2- trifluoromethylpyrimidine-4-carbonitrile (0.22 g), and the mixture was stirred at room
temperature for 20 hours. Water was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was washed with t-butylmethyl ether to obtain N'- hydroxy-2-(trifluoromethyl)pyrimidine-4-carboximidamide (0.18 g).
[0213] <Step 5-2> Synthesis of 3-[2-(trifluoromethyl)pyrimidin-4-yl]1 ,2,4-oxadiazol-5(4H)-one (G3-1)
[0214] N'-Hydroxy-2-(trifluoromethyl)pyrimidine-4-carboximidamide (0.18 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.16 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.16 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was washed with t-butylmethyl ether to obtain 3-[2-(trifluoromethyl)pyrimidin-4-yl]1 ,2,4- oxadiazol-5(4H)-one (0.14 g).
Example 6: Synthesis of 3-{2-r(2,2,2-trifluoroethyl)sulfanvnpyrimidin-4-yl)1 ,2,4- oxadiazol-5(4H)-one (G3-10)
[0215] <Step 6-1 > Synthesis of 2-[(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carbonitrile
[0216] A dimethylformamide solution of trifluoroethanethiol (0.3 g) was dropped onto a dimethylformamide suspension of sodium hydride (0.11 g) at 0°C. The mixture was stirred for 30 minutes, and then, a dimethylformamide solution of 2-chloropyrimidine-4-carbonitrile (0.3 g) was added thereto. The mixture was stirred at room temperature for 3 hours, and then, water was added thereto, followed by extraction with ethyl acetate. The organic layer was separated, then washed with water and saturated saline and dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 2-[(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carbonitrile (0.4 g).
[0217] <Step 6-2> Synthesis of N'-hydroxy-2-(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4- carboximidamide
[0218] An aqueous hydroxylamine solution (0.16 g) was added to an ethanolic solution of 2- [(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carbonitrile (0.32 g), and the mixture was stirred at room temperature for 20 hours. Water was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was washed with t-butylmethyl ether to obtain N'-hydroxy-2-(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carboximidamide (0.33 g).
[0219] <Step 6-3> Synthesis of 3-{2-[(2,2,2-trifluoroethyl)sulfanyl]pyrimidin-4-yl}1 ,2,4- oxadiazol-5(4H)-one (G3-10)
[0220] N'-Hydroxy-2-(2,2,2-trifluoroethyl)sulfanyl]pyrimidine-4-carboximidamide (0.2 g) was dissolved in tetrahydrofuran. Carbonyldiimidazole (0.14 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. 1 ,8-diazabicyclo[5.4.0]-7-undecene (0.16 g) was added thereto, and the mixture was stirred at room temperature for 5 hours. 2 N hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was separated and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was washed with t-butylmethyl ether to obtain 3-{2-[(2,2,2- trifluoroethyl)sulfanyl]pyrimidin-4-yl}1 ,2,4-oxadiazol-5(4H)-one (0.22 g).
Example 7: Synthesis of 3-ri-methyl-5-(trifluoromethyl)-1 H-imidazol-2-vn-1 ,2,4- oxadiazol-5(4H)-one (G6-113)
[0222] n-Butyllithium (5 ml, 1.6 M hexane solution) was dropped onto a tetrahydrofuran solution of 1-methyl-5-(trifluoromethyl)-1 H-imidazole (1.1 g) at -78°C in an argon atmosphere. The mixture was stirred for 30 minutes, and then, a tetrahydrofuran solution (2 ml) of dimethylformamide (0.59 g) was dropped thereon. The mixture was stirred at 0°C for 2 hours, and then, the reaction solution was added to ice water, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 1-methyl-5-(trifluoromethyl)-1 H-imidazole-2- carbaldehyde (1.24 g).
[0223] <Step 7-2> Synthesis of 1-methyl-5-(trifluoromethyl)-1 H-imidazole-2-carbonitrile
[0224] 1-Methyl-5-(trifluoromethyl)-1 H-imidazole-2-carbaldehyde (1.24 g) was dissolved in pyridine (50 ml). Hydroxylamine hydrochloride (2.02 g) was added thereto, and the mixture was stirred at 50°C for 1 hour. After cooling to room temperature, the solvent was
concentrated. The residue was dissolved in acetic anhydride (70 ml), and the solution was stirred at 100°C for 3 hours and at 125°C for 1 hour. The solvent was concentrated, and water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium hydrogencarbonate solution and saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 1-methyl-5- (trifluoromethyl)-1 H-imidazole-2-carbonitrile (1.17 g).
[0225] <Step 7-3> Synthesis of N'-hydroxy-1-methyl-5-(trifluoromethyl)-1 H-imidazole-2- carboximidamide
[0226] An ethanol suspension (13 ml) of hydroxylamine hydrochloride (1.01 g) and sodium hydrogencarbonate (1.22 g) was heat-refluxed for 45 minutes. After cooling to room
temperature, an ethanolic solution (2 ml) of 1-methyl-5-(trifluoromethyl)-1 H-imidazole-2- carbonitrile (1.21 g) was added thereto at 0°C, and the mixture was stirred overnight at room temperature. The solvent was concentrated, and then, water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain N'-hydroxy-1-methyl-5- (trifluoromethyl)-1 H-imidazole-2-carboximidamide (0.98 g).
[0227] <Step 7-4> Synthesis of 3-[1-methyl-5-(trifluoromethyl)-1 H-imidazol-2-yl]-1 ,2,4- oxadiazol-5(4H)-one (G6-1 13)
[0228] Carbonyldiimidazole (0.39 g) was added to a tetrahydrofuran solution (8 ml) of N'- hydroxy-1-methyl-5-(trifluoromethyl)-1 H-imidazole-2-carboximidamide (0.42 g) in an argon atmosphere, and the mixture was stirred at room temperature for 2 hours. DBU (0.37 g) was added thereto, and stirring was continued for additional 6 hours. 10% hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[1-methyl-5-(trifluoromethyl)-1 H-imidazol-2-yl]- 1 ,2,4-oxadiazol-5(4H)-one (0.15 g).
Example 8: Synthesis of 3-ri-methyl-3-(trifluoromethyl)-1 H-pyrazol-5-vn-1 ,2,4-oxadiazol-
5(4H)-one (G4-113)
[0229] <Step 8-1 > Synthesis of 1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboxamide
[0230] 1-Methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboxylic acid (4.85 g) and dimethylformamide (0.04 g) were dissolved in dichloromethane (80 ml), and a dichloromethane solution (20 ml) of oxalyl chloride (3.33 g) was dropped thereon. The mixture was stirred at room temperature for 1 hour, and then, the solvent was concentrated. The residue was dissolved in dichloromethane (15 ml), and a mixed solution of 28% ammonia water (15.2 g) and dichloromethane (25 ml) was added thereto at 0°C. The mixture was stirred at room temperature for 1 hour, and then, the organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated to obtain crude 1-methyl-3- (trifluoromethyl)-1 H-pyrazole-5-carboxamide (4.29 g).
[0231] <Step 8-2> Synthesis of 1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carbonitrile
[0232] 1-Methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboxamide (0.97 g) and triethylamine (1.52 g) were dissolved in dichloromethane (25 ml), and trifluoroacetic anhydride was added thereto at 0°C. The mixture was stirred at 0°C for 1 hour and then at room temperature for 2 hours. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carbonitrile (0.74 g).
[0233] <Step 8-3> Synthesis of N'-hydroxy-1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5- carboximidamide
[0234] An ethanol suspension (10 ml) of hydroxylamine hydrochloride (0.59 g) and sodium hydrogencarbonate (0.72 g) was heat-refluxed for 45 minutes. After cooling to room temperature, an ethanol solution (2 ml) of 1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5- carbonitrile (0.71 g) was added thereto at -5°C, and the mixture was stirred at room
temperature for 5 hours. The solvent was concentrated, and then, water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was
concentrated, and the residue was purified by silica gel column chromatography to obtain N'- hydroxy-1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboximidamide (0.81 g).
[0235] <Step 8-4> Synthesis of 3-[1-methyl-3-(trifluoromethyl)-1 H-pyrazol-5-yl]-1 ,2,4- oxadiazol-5(4H)-one (G4-1 13)
[0236] Carbonyldiimidazole (0.47 g) was added to a tetrahydrofuran solution (8 ml) of N'- hydroxy-1-methyl-3-(trifluoromethyl)-1 H-pyrazole-5-carboximidamide (0.5 g) in an argon atmosphere, and the mixture was stirred at room temperature for 2 hours. DBU (0.44 g) was added thereto, and stirring was continued for additional 6 hours. 10% hydrochloric acid was added thereto, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[1-methyl-3-(trifluoromethyl)-1 H-pyrazol-5-yl]- 1 ,2,4-oxadiazol-5(4H)-one (0.3 g).
Example 9: Synthesis of 4-methyl-3-ri-methyl-5-(trifluoromethyl)-1 H-pyrazol-3-vn-1 ,2,4- oxadiazol-5(4H)-one (G5-354)
[0237] <Step 9-1 > Synthesis of 3-(2-furyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1 H- pyrazol-5-ol
[0238] Methylhydrazine (3.46 g) was dropped onto an ethanolic solution (100 ml) of 4,4,4- trifluoro-1-(2-furyl)butane-1 ,3-dione (10.31 g) at 0°C. The mixture was stirred at room temperature for 1 hour, and then, the solvent was concentrated. The residue was dissolved in ethyl acetate, and the solution was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was
purified by silica gel column chromatography to obtain 3-(2-furyl)-1-methyl-5-(trifluoromethyl)- 4,5-dihydro-1 H-pyrazol-5-ol (3.25 g).
[0239] <Step 9-2> Synthesis of 3-(2-furyl)-1-methyl-5-(trifluoromethyl)1 H-pyrazole
[0240] 3-(2-Furyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1 H-pyrazol-5-ol (3.25 g) and 3 N hydrochloric acid (16.2 ml) were dissolved in tetrahydrofuran (60 ml), and the solution was heat-refluxed for 30 minutes. After cooling to room temperature, the solvent was concentrated. The residue was subjected to extraction with ethyl acetate, and the organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 3-(2-furyl)-1-methyl-5-(trifluoromethyl)1 H-pyrazole (2.14 g).
[0241] <Step 9-3> Synthesis of 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboxylic acid
[0242] An aqueous solution (130 ml) of potassium permanganate (8.14 g) was added to an acetone solution (100 ml) of 3-(2-furyl)-1-methyl-5-(trifluoromethyl)1 H-pyrazole (2.1 g). The reaction mixture was stirred at 60°C for 4 hours and then cooled to room temperature.
Isopropanol (30 ml) was added thereto, and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through celite, and the filtrate was concentrated to approximately 30 ml. 2 N aqueous sodium hydroxide solution (7 ml) was added to the residue, and the solution was washed with t-butylmethyl ether. 5 N hydrochloric acid (10 ml) was added to the aqueous layer, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was concentrated to obtain crude 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboxylic acid (1.59 g).
[0244] 1-Methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboxylic acid (1.58 g) and
dimethylformamide (0.01 g) were dissolved in dichloromethane (20 ml), and a dichloromethane solution (5 ml) of oxalyl chloride (1.09 g) was dropped thereon. The mixture was stirred at room temperature for 1 hour, and then, the solvent was concentrated. The residue was dissolved in dichloromethane (50 ml), and a mixed solution of 28% ammonia water (4.95 g) and dichloromethane (50 ml) was added thereto at 0°C. The mixture was stirred at room temperature for 1 hour, and then, the organic layer was separated and dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboxamide
(0.91 g).
[0245] <Step 9-5> Synthesis of 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carbonitrile
[0246] 1-Methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboxamide (1.31 g) and triethylamine (2.06 g) were dissolved in dichloromethane (25 ml), and trifluoroacetic anhydride (2.14 g) was added thereto at 0°C. The mixture was stirred at 0°C for 1 hour and then at room temperature for 2 hours. The solvent was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carbonitrile (1.1
[0247] <Step 9-6> Synthesis of N'-hydroxy-1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3- carboximidamide
[0248] An ethanol suspension (10 ml) of hydroxylamine hydrochloride (0.92 g) and sodium hydrogencarbonate (1.11 g) was heat-refluxed for 45 minutes. After cooling to room temperature, an ethanol solution (2 ml) of 1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3- carbonitrile (1.18 g) was added thereto at 0°C, and the mixture was stirred at room
temperature for 3 hours. The solvent was concentrated, and then, water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain N'- hydroxy-1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboximidamide (1.0 g).
[0249] <Step 9-7> Synthesis of 3-[1-methyl-5-(trifluoromethyl)-1 H-pyrazol-3-yl]-1 ,2,4- oxadiazol-5(4H)-one (G5-1 13)
[0250] Carbonyldiimidazole (1.67 g) was added to a tetrahydrofuran solution (28 ml) of N'- hydroxy-1-methyl-5-(trifluoromethyl)-1 H-pyrazole-3-carboximidamide (1.79g) in an argon atmosphere, and the mixture was stirred at room temperature for 2 hours. DBU (1.57 g) was added thereto, and stirring was continued for additional 6 hours. 2 N hydrochloric acid was added thereto at 0°C, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and the residue was purified by silica gel column chromatography to obtain 3-[1- methyl-5-(trifluoromethyl)-1 H-pyrazol-3-yl]-1 ,2,4-oxadiazol-5(4H)-one (1.13 g).
[0251] <Step 9-8> Synthesis of 4-methyl-3-[1-methyl-5-(trifluoromethyl)-1 H-pyrazol-3-yl]- 1 ,2,4-oxadiazol-5(4H)-one (G5-354)
[0252] 3-[1-Methyl-5-(trifluoromethyl)-1 H-pyrazol-3-yl]-1 ,2,4-oxadiazol-5(4H)-one (0.79 g) was added to a dimethylformamide (5 ml) suspension of 60% sodium hydride (0.14 g) at 0°C in an argon atmosphere. The mixture was stirred at room temperature. Again, the reaction solution was cooled to 0°C, and methyl iodide (0.58 g) was added thereto. The mixture was
stirred at 0°C for 2 hours and then overnight at room temperature. The reaction solution was added to ice water, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated saline and then dried over anhydrous magnesium sulfate. The solvent was concentrated, and then, the residue was purified by silica gel column
chromatography to obtain 4-methyl-3-[1-methyl-5-(trifluoromethyl)-1 H-pyrazol-3-yl]-1 ,2,4- oxadiazol-5(4H)-one (0.78 g).
[0253] Compounds of the formula (I) of the present invention obtained by the same processes as employed in Examples 1 to 9 above or according to the processes described in detail above, and their physical property values are summarized in Tables 1 to 9 and NMR tables. In addition, each of the compounds obtained in the above synthetic examples is also shown in the corresponding table.
[0254] Abbreviations in the tables are as follows:
[0255] n-: normal-, c-hex: cyclohexyl, c-pen: cyclopentyl, c-hep: cycloheptyl, c-pro:
cyclopropyl, Ph: phenyl, pyridyl: pyridyl
Example 10: Biological Test
[0256] Drug samples were prepared as follows, unless otherwise specified.
Solvent: 3 parts by weight of dimethylformamide
Emulsifier: 1 part by weight of polyoxyethylene alkylphenyl ether
[0257] To prepare formulations of appropriate active compounds, 1 part by weight of active compound was mixed with the solvent in the amount above containing the emulsifier in the amount above, and the mixture was diluted with water to a predetermined concentration.
Ammonium salt or ammonium salt and penetration enhancer in a dosage of l OOOppm are added to the desired concentration if necessary.
10.1 Test on Myzus persicae resistant to organic phosphorus and carbamate agents Test Method
[0258] Eggplant leaves with two developed true leaves cultivated in a pot of 6 cm in diameter were inoculated with raised Myzus persicae resistant to organic phosphorus and carbamate agents at a dose of approximately 50 to 100 insects per seedling. One day after the inoculation, the prepared aqueous dilution of the active compound at the predetermined concentration was spreaded thereto in a sufficient amount using a spray gun. After the spreading, the seedlings were left in a greenhouse. Seven days after the spreading,
insecticidal rates were calculated. The insecticidal rate of 100% means that all the insects (Myzus persicae) died. On the other hand, the insecticidal rate of 0% means that none of the insects (Myzus persicae) died.
Test Results
[0259] The compounds of Compound Nos. G1-1 , G1-7, G1-25, G2-1 , G3-1 , G4-1 13, and G8-1 as typical examples exhibited control effect with the insecticidal rate of 100% at an active ingredient concentration of 500 ppm.
10.2 Test 2 on Myzus persicae - spray test (MYZUPE - OP/Carb-resistant) Test Method 2
Solvent: 3 parts by weight dimethylformamide
Emulsifier: 1 part by weight polyoxyethylene alkyl phenyl ether
[0260] In order to make an appropriate formulation of an active compound, 1 part by weight of the active compound is mixed with the above mentioned amount of solvent and emulsifier and the mixture is diluted with water to a prescribed concentration. Ammonium salt or ammonium salt and penetration enhancer in a dosage of lOOOppm are added to the desired concentration if necessary.
[0261] 1 day before treatment, all instars of the green peach aphid (Myzus persicae) are inoculated onto the 2-leaf stage of eggplant seedlings (Solarium melongena). The compound solution is sprayed directly onto both insects and plants. After drying, the pots are placed in the greenhouse, at 20°C to 25°C.
[0262] After 2 days mortality in % is determined. An insecticidal activity of 100 % means that all larvae have been killed, an insecticidal activity of 0 % means that no larvae have been killed.
[0263] In this test the following compounds showed an insecticidal activity of 100% at an active compound concentration of 500ppm: G1-16
[0264] In this test the following compounds showed an insecticidal activity of 98% at an active compound concentration of 500ppm: G13-20, G15-103,
[0265] In this test the following compounds showed an insecticidal activity of 90% at an active compound concentration of 500ppm: G3-10
[0266] After 6 days mortality in % is determined. An insecticidal activity of 100 % means that all larvae have been killed, an insecticidal activity of 0 % means that no larvae have been killed.
[0267] In this test the following compounds showed an insecticidal activity of 100% at an active compound concentration of 500ppm: G1-1 , G1-7, G1-15, G1-25, G2-1 , G3-1 , G4-113, G8-1 , G9-1 , G16-1 , G18-1
[0268] In this test the following compounds showed an insecticidal activity of 98% at an active compound concentration of 500ppm: G1-2, G1-18, G4-1521 , G4-1557, G6-1 13
[0269] In this test the following compounds showed an insecticidal activity of 90% at an active compound concentration of 500ppm: G1-17, G3-45, G5-1 13, G7-19, G8-104
[0270] In this test the following compounds showed an insecticidal activity of 90% at an active compound concentration of 100ppm: G17-112
10.3 Two-spotted spider mite (TETRUR)
Solvent: 3 parts by weight dimethylformamide
Emulsifier: 1 part by weight polyoxyethylene alkyl phenyl ether
[0271] In order to make an appropriate formulation of an active compound, 1 part by weight of the active compound is mixed with the above mentioned amount of solvent and emulsifier and the mixture is diluted with water to a prescribed concentration. Ammonium salt or ammonium salt and penetration enhancer in a dosage of lOOOppm are added to the desired concentration if necessary.
[0272] 1 day before treatment, the apex parts of kidney bean seedlings (Phaseolus vulgaris) are pruned. About 20 adults of the two-spotted spider mite (Tetranychus urticae) are inoculated onto each leaf, about 40 adults and some nymphs per pot. A paper label is placed on each pot.
[0273] The solution is sprayed directly onto both mites and plants. After drying, pots are placed in the greenhouse at 20°C- 25°C.
[0274] After 2 days, the acaricidal activity is calculated. An acaricidal activity of 100 % means that all mites have been killed, an acaricidal activity of 0 % means that no mites have been killed.
[0275] In this test the following compounds showed an acaricidal activity of 98% at an active compound concentration of 500ppm: G1-52, G15-103
[0276] In this test the following compounds showed an acaricidal activity of 90% at an active compound concentration of 500ppm: G1-90, G4-1557, G18-1 , G14-49
[0277] After 6 days, the acaricidal activity is calculated. An acaricidal activity of 100 % means that all mites have been killed, an acaricidal activity of 0 % means that no mites have been killed.
[0278] In this test the following compounds showed an acaricidal activity of 100% at an active compound concentration of 500ppm: G2-1 , G9-1 , G14-103
[0279] In this test the following compounds showed an acaricidal activity of 98% at an active compound concentration of 500ppm: G5-113
[0280] In this test the following compounds showed an acaricidal activity of 90% at an active compound concentration of 500ppm: G1-18, G4-1534, G8-20, G16-1
10.4 Bemisia spray-test (BEMIAR)
Solvent: 3 parts by weight dimethylformamide
Emulsifier: 1 part by weight polyoxyethylene alkyl phenyl ether
[0281] In order to make an appropriate formulation of an active compound, 1 part by weight of the active compound is mixed with the above mentioned amount of solvent and emulsifier and the mixture is diluted with water to a prescribed concentration. Ammonium salt or ammonium salt and penetration enhancer in a dosage of lOOOppm are added to the desired concentration if necessary.
[0282] Tomato seedlings (Lycopersicon esculentum) are treated by being sprayed with the desired concentration of the compound solution. After drying, the treated pots are placed in the greenhouse where they are inoculated with the silverleaf whitefly (Bemisia argentifolii) for an infection-time of 24h. Afterwards, the plants are placed in a room at 25°C and 50-60 % r.h., with 16L8D lighting conditions.
[0283] After 14 days, the insecticidal activity is calculated. An insecticidal activity of 100 % means that all whiteflies have been killed, an insecticidal activity of 0 % means that no whiteflies have been killed.
[0284] In this test the following compounds showed an insecticidal activity of 90% at an active compound concentration of 100ppm: G16-1.
10.5 Thrips palmi - spraytest (THRIPL)
Solvent: Dimethylformamide, 3 parts by weight
Emulsifier: Polyoxyethylene alkyl phenyl ether, 1 part by weight
[0285] In order to make an appropriate formulation of an active compound, 1 part by weight of the active compound is mixed with the above mentioned amount of solvent and emulsifier and the mixture is diluted with water to a prescribed concentration. Ammonium salt or ammonium salt and penetration enhancer in a dosage of lOOOppm are added to the desired concentration if necessary.
[0286] The compound solutions are sprayed to a cucumber seedling (Cucumis sativus). After drying, the treated plant is placed in a plastic stand. About 100 thrips-eggs (Thrips palmi) on a piece of filter paper are attached to the plant and covered with a cage to keep 100% humidity. The plant is kept in a room at 23°C.
[0287] After 6 days activity in % is evaluated by feeding damage degree. An activity of 100 % means that there is no feeding damage, an activity of 0 % means that there is no difference to the untreated control.
[0288] In this test the following compounds showed an insecticidal activity of 98% at an active compound concentration of 500ppm: G5-354
Example 11 : Formulation Preparation Example
Preparation Example 1 (Granule)
[0289] 25 parts of water are added to a mixture of 10 parts of the compound of the present invention (No. G1-1), 30 parts of bentonite (montmorillonite), 58 parts of talc, and 2 parts of lignin sulfonate, and the mixture is well kneaded, then granulated with 10- to 40-mesh size using an extrusion granulator, and dried at 40 to 50°C to form a granule.
Preparation Example 2 (Granule)
[0290] 95 parts of clay mineral particles having particle size distribution within the range of 0.2 to 2 mm are fed to a rotational mixing machine, then uniformly moistened by the spraying
of 5 parts of the compound of the present invention (No. G1-1) together with a liquid diluent under rotation, and then dried at 40 to 50°C to form a granule.
Preparation Example 3 (Emulsifiable Concentrate)
[0291] 30 parts of the compound of the present invention (No. G1-1), 55 parts of xylene, 8 parts of polyoxyethylene alkylphenyl ether and 7 parts of calcium alkylbenzenesulfonate are mixed and stirred to form an emulsifiable concentrate.
Preparation Example 4 (Wettable Powder)
[0292] 15 parts of the compound of the present invention (No. G1-1), 80 parts of a mixture of white carbon (fine powder of hydrous amorphous silicon oxide) and clay powder (1 :5), 2 parts of sodium alkylbenzenesulfonate, and 3 parts of sodium alkylnaphthalenesulfonate-formalin condensate are pulverized and mixed to form a wettable powder.
Preparation Example 5 (Wettable Granule)
[0293] 20 parts of the compound of the present invention (No. G1-1), 30 parts of sodium salt of lignin sulfonic acid, 15 parts of bentonite and 35 parts of calcined diatomaceous earth powder are sufficiently mixed. After addition of water, the mixture is extruded with a 0.3 mm screen and dried to form wettable granules.
[0294] Table 1
G 1-286 2-CF3Ph (3-FPh)OCH2
G1-287 2-CF3Ph (4-FPh)OCH2
G1-288 2-CF3Ph (2-CIPh)OCH2
G1-289 2-CF3Ph (3-CIPh)OCH2
G1-290 2-CF3Ph (4-CIPh)OCH2
G1-291 2-CF3Ph (2-BrPh)OCH2
G 1-292 2-CF3Ph (3-BrPh)OCH2
G1-293 2-CF3Ph (4-BrPh)OCH2
G 1-294 2-CF3Ph (2-CF3OPh)OCH2
G1-295 2-CF3Ph (3-CF3OPh)OCH2
G 1-296 2-CF3Ph (4-CF3OPh)OCH2
G1-297 2-CF3Ph (2-CNPh)OCH2
G1-298 2-CF3Ph (3-CNPh)OCH2
G1-299 2-CF3Ph (4-CNPh)OCH2
G1-300 2-CF3Ph (2-N02Ph)OCH2
G1-301 2-CF3Ph (3-N02Ph)OCH2
G1-302 2-CF3Ph (4-N02Ph)OCH2
G1-303 2-CF3Ph (2-CF3Ph)OCH2
G1-304 2-CF3Ph (3-CF3Ph)OCH2
G1-305 2-CF3Ph (4-CF3Ph)OCH2
G1-306 2-CF3Ph PhCH2OCH2
G1-307 2-CF3Ph (2-CH3Ph)CH2OCH2
G1-308 2-CF3Ph (3-CH3Ph)CH2OCH2
G1-309 2-CF3Ph (4-CH3Ph)CH2OCH2
G1-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G1-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G1-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G1-313 2-CF3Ph (2-FPh)CH2OCH2
G1-314 2-CF3Ph (3-FPh)CH2OCH2
G1-315 2-CF3Ph (4-FPh)CH2OCH2
G1-316 2-CF3Ph (2-CIPh)CH2OCH2
G1-317 2-CF3Ph (3-CIPh)CH2OCH2
G1-318 2-CF3Ph (4-CIPh)CH2OCH2
G1-319 2-CF3Ph (2-BrPh)CH2OCH2
G1-320 2-CF3Ph (3-BrPh)CH2OCH2
G1-321 2-CF3Ph (4-BrPh)CH2OCH2
G 1-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G1-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G 1-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G1-325 2-CF3Ph (2-CNPh)CH2OCH2
G 1-326 2-CF3Ph (3-CNPh)CH2OCH2
G1-327 2-CF3Ph (4-CNPh)CH2OCH2
G1-328 2-CF3Ph (2-N02Ph)CH2OCH2
G1-329 2-CF3Ph (3-N02Ph)CH2OCH2
G1-330 2-CF3Ph (4-N02Ph)CH2OCH2
G1-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G1-382 3-CF3Ph (CH3)3CCH2CH2C(=0)
G1-383 3-CF3Ph CH3CH2C(CH3)2C(=0)
G1-384 3-CF3Ph (c-hex)C(=0)
G1-385 3-CF3Ph (c-pen)C(=0)
G1-386 3-CF3Ph (c-hep)C(=0)
G1-387 3-CF3Ph (c-pro)C(=0)
G1-388 3-CF3Ph CF3C(=0)
G1-389 3-CF3Ph (CH3)2NC(=0)
G1-390 3-CF3Ph (CH3CH2)2NC(=0)
G1-391 3-CF3Ph (CH3CH2CH2)2NC(=0)
G1-392 3-CF3Ph CH3CH2N(CH3)C(=0)
G1-393 3-CF3Ph [(CH3)2CHCH2]2NC(=0)
G1-394 3-CF3Ph CH3ON(CH3)C(=0)
G1-395 3-CF3Ph (CH2=CHCH2)2N C(=0)
G1-396 3-CF3Ph (CHCCH2)2NC(=0)
CO-N^]
G1-397 3-CF3Ph
CO-N^
G1-398 3-CF3Ph
CO-N^O
G1-399 3-CF3Ph
G1-400 3-CF3Ph CH3OCH2
G1-401 3-CF3Ph CH3CH2OCH2
G 1-402 3-CF3Ph (CH3)2CHOCH2
G1-403 3-CF3Ph (CH3)3COCH2
G 1-404 3-CF3Ph (CH3)3CCH20CH2
G1-405 3-CF3Ph CH3CH2C(CH3)2OCH2
G 1-406 3-CF3Ph (c-hex)OCH2
G1-407 3-CF3Ph PhOCH2
G1-408 3-CF3Ph (2-CH3Ph)OCH2
G1-409 3-CF3Ph (3-CH3Ph)OCH2
G1-410 3-CF3Ph (4-CH3Ph)OCH2
G1-411 3-CF3Ph (2-CH3OPh)OCH2
G1-412 3-CF3Ph (3-CH3OPh)OCH2
G1-413 3-CF3Ph (4-CH3OPh)OCH2
G1-414 3-CF3Ph (2-FPh)OCH2
G1-415 3-CF3Ph (3-FPh)OCH2
G1-416 3-CF3Ph (4-FPh)OCH2
G1-417 3-CF3Ph (2-CIPh)OCH2
G1-418 3-CF3Ph (3-CIPh)OCH2
G1-419 3-CF3Ph (4-CIPh)OCH2
G 1-420 3-CF3Ph (2-BrPh)OCH2
G1-421 3-CF3Ph (3-BrPh)OCH2
G 1-422 3-CF3Ph (4-BrPh)OCH2
G 1-423 3-CF3Ph (2-CF3OPh)OCH2
G 1-424 3-CF3Ph (3-CF3OPh)OCH2
G 1-425 3-CF3Ph (4-CF3OPh)OCH2
G 1-426 3-CF3Ph (2-CNPh)OCH2
G 1-427 3-CF3Ph (3-CNPh)OCH2
G 1-428 3-CF3Ph (4-CNPh)OCH2
G 1-429 3-CF3Ph (2-N02Ph)OCH2
G1-430 3-CF3Ph (3-N02Ph)OCH2
G1-431 3-CF3Ph (4-N02Ph)OCH2
G 1-432 3-CF3Ph (2-CF3Ph)OCH2
G1-433 3-CF3Ph (3-CF3Ph)OCH2
G 1-434 3-CF3Ph (4-CF3Ph)OCH2
G1-435 3-CF3Ph PhCH2OCH2
G 1-436 3-CF3Ph (2-CH3Ph)CH2OCH2
G1-437 3-CF3Ph (3-CH3Ph)CH2OCH2
G1-438 3-CF3Ph (4-CH3Ph)CH2OCH2
G1-439 3-CF3Ph (2-CH3OPh)CH2OCH2
G 1-440 3-CF3Ph (3-CH3OPh)CH2OCH2
G1-441 3-CF3Ph (4-CH3OPh)CH2OCH2
G 1-442 3-CF3Ph (2-FPh)CH2OCH2
G 1-443 3-CF3Ph (3-FPh)CH2OCH2
G 1-444 3-CF3Ph (4-FPh)CH2OCH2
G 1-445 3-CF3Ph (2-CIPh)CH2OCH2
G 1-446 3-CF3Ph (3-CIPh)CH2OCH2
G 1-447 3-CF3Ph (4-CIPh)CH2OCH2
G 1-448 3-CF3Ph (2-BrPh)CH2OCH2
G 1-449 3-CF3Ph (3-BrPh)CH2OCH2
G1-450 3-CF3Ph (4-BrPh)CH2OCH2
G1-451 3-CF3Ph (2-CF3OPh)CH2OCH2
G 1-452 3-CF3Ph (3-CF3OPh)CH2OCH2
G1-453 3-CF3Ph (4-CF3OPh)CH2OCH2
G 1-454 3-CF3Ph (2-CNPh)CH2OCH2
G1-455 3-CF3Ph (3-CNPh)CH2OCH2
G 1-456 3-CF3Ph (4-CNPh)CH2OCH2
G1-457 3-CF3Ph (2-N02Ph)CH2OCH2
G1-458 3-CF3Ph (3-N02Ph)CH2OCH2
G1-459 3-CF3Ph (4-N02Ph)CH2OCH2
G 1-460 3-CF3Ph (2-CF3Ph)CH2OCH2
G1-461 3-CF3Ph (3-CF3Ph)CH2OCH2
G 1-462 3-CF3Ph (4-CF3Ph)CH2OCH2
G 1-463 3-CF3Ph CH3C(=0)OCH2
G 1-464 3-CF3Ph CH3CH2C(=0)OCH2
G 1-465 3-CF3Ph CH(CH3)2C(=0)OCH2
G 1-466 3-CF3Ph (CH3)3C(=0)OCH2
G 1-467 3-CF3Ph (CH3)3CCH2(=0)OCH2
G 1-468 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 1-469 3-CF3Ph CF3C(=0)OCH2
G 1-562 4-CF3Ph (3-CF3Ph)OCH2
G1-563 4-CF3Ph (4-CF3Ph)OCH2
G 1-564 4-CF3Ph PhCH2OCH2
G1-565 4-CF3Ph (2-CH3Ph)CH2OCH2
G 1-566 4-CF3Ph (3-CH3Ph)CH2OCH2
G1-567 4-CF3Ph (4-CH3Ph)CH2OCH2
G1-568 4-CF3Ph (2-CH3OPh)CH2OCH2
G1-569 4-CF3Ph (3-CH3OPh)CH2OCH2
G1-570 4-CF3Ph (4-CH3OPh)CH2OCH2
G1-571 4-CF3Ph (2-FPh)CH2OCH2
G1-572 4-CF3Ph (3-FPh)CH2OCH2
G1-573 4-CF3Ph (4-FPh)CH2OCH2
G1-574 4-CF3Ph (2-CIPh)CH2OCH2
G1-575 4-CF3Ph (3-CIPh)CH2OCH2
G1-576 4-CF3Ph (4-CIPh)CH2OCH2
G1-577 4-CF3Ph (2-BrPh)CH2OCH2
G1-578 4-CF3Ph (3-BrPh)CH2OCH2
G1-579 4-CF3Ph (4-BrPh)CH2OCH2
G1-580 4-CF3Ph (2-CF3OPh)CH2OCH2
G1-581 4-CF3Ph (3-CF3OPh)CH2OCH2
G1-582 4-CF3Ph (4-CF3OPh)CH2OCH2
G1-583 4-CF3Ph (2-CNPh)CH2OCH2
G1-584 4-CF3Ph (3-CNPh)CH2OCH2
G1-585 4-CF3Ph (4-CNPh)CH2OCH2
G1-586 4-CF3Ph (2-N02Ph)CH2OCH2
G1-587 4-CF3Ph (3-N02Ph)CH2OCH2
G1-588 4-CF3Ph (4-N02Ph)CH2OCH2
G1-589 4-CF3Ph (2-CF3Ph)CH2OCH2
G1-590 4-CF3Ph (3-CF3Ph)CH2OCH2
G1-591 4-CF3Ph (4-CF3Ph)CH2OCH2
G1-592 4-CF3Ph CH3C(=0)OCH2
G1-593 4-CF3Ph CH3CH2C(=0)OCH2
G1-594 4-CF3Ph CH(CH3)2C(=0)OCH2
G1-595 4-CF3Ph (CH3)3C(=0)OCH2
G1-596 4-CF3Ph (CH3)3CCH2(=0)OCH2
G1-597 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G1-598 4-CF3Ph CF3C(=0)OCH2
G1-599 4-CF3Ph CF3CF2C(=0)OCH2
G1-600 4-CF3Ph (c-hex)C(=0)OCH2
G1-601 4-CF3Ph PhC(=0)OCH2
G 1-602 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G1-603 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G 1-604 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G1-605 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G 1-606 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G1-607 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G1-608 4-CF3Ph (2-FPh)C(=0)OCH2
G1-609 4-CF3Ph (3-FPh)C(=0)OCH2
G1-610 4-CF3Ph (4-FPh)C(=0)OCH2
G1-611 4-CF3Ph (2-CIPh)C(=0)OCH2
G1-612 4-CF3Ph (3-CIPh)C(=0)OCH2
G1-613 4-CF3Ph (4-CIPh)C(=0)OCH2
G1-614 4-CF3Ph (2-BrPh)C(=0)OCH2
G1-615 4-CF3Ph (3-BrPh)C(=0)OCH2
G1-616 4-CF3Ph (4-BrPh)C(=0)OCH2
G1-617 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G1-618 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G1-619 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G 1-620 4-CF3Ph (2-CNPh)C(=0)OCH2
G1-621 4-CF3Ph (3-CNPh)C(=0)OCH2
G 1-622 4-CF3Ph (4-CNPh)C(=0)OCH2
G 1-623 4-CF3Ph (2-N02Ph)C(=0)OCH2
G 1-624 4-CF3Ph (3-N02Ph)C(=0)OCH2
G 1-625 4-CF3Ph (4-N02Ph)C(=0)OCH2
G 1-626 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G 1-627 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G 1-628 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G 1-629 3,5-(CF3)2Ph CH3
G1-630 3,5-(CF3)2Ph CH3CH2
G1-631 3,5-(CF3)2Ph CH3CH2CH2
G 1-632 3,5-(CF3)2Ph (CH3)2CH
G1-633 3,5-(CF3)2Ph CH3C(=0)
G 1-634 3,5-(CF3)2Ph CH3CH2C(=0)
G1-635 3,5-(CF3)2Ph (CH3)2CHC(=0)
G 1-636 3,5-(CF3)2Ph (CH3)3CC(=0)
G1-637 3,5-(CF3)2Ph (CH3)3CCH2C(=0)
G1-638 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0)
G1-639 3,5-(CF3)2Ph (CH3)2CHCH2C(=0)
G 1-640 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0)
G1-641 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)
G 1-642 3,5-(CF3)2Ph (c-hex)C(=0)
G 1-643 3,5-(CF3)2Ph (c-pen)C(=0)
G 1-644 3,5-(CF3)2Ph (c-hep)C(=0)
G 1-645 3,5-(CF3)2Ph (c-pro)C(=0)
G 1-646 3,5-(CF3)2Ph CF3C(=0)
G 1-647 3,5-(CF3)2Ph (CH3)2NC(=0)
G 1-648 3,5-(CF3)2Ph (CH3CH2)2NC(=0)
G 1-649 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0)
G1-650 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0)
G1-651 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0)
G 1-652 3,5-(CF3)2Ph CH3ON(CH3)C(=0)
G1-653 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0)
G1-698 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G1-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G1-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G1-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G1-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G1-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G1-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G1-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G1-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G1-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G1-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G1-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G1-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G1-711 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G1-712 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G1-713 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G1-714 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G1-715 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G1-716 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G1-717 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G1-718 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G1-719 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G1-720 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G1-721 3,5-(CF3)2Ph CH3C(=0)OCH2
G 1-722 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G1-723 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G 1-724 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G1-725 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G 1-726 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G1-727 3,5-(CF3)2Ph CF3C(=0)OCH2
G1-728 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G1-729 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G1-730 3,5-(CF3)2Ph PhC(=0)OCH2
G1-731 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G1-732 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G1-733 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G1-734 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G1-735 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G1-736 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G1-737 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G1-738 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G1-739 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G1-740 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G1-741 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G 1-742 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G1-743 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G 1-744 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G1-745 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G 1-746 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G1-747 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G1-748 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G1-749 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G1-750 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G1-751 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G1-752 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G1-753 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G1-754 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G1-755 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G1-756 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G1-757 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0295] Table 2
G2-297 2-CF3Ph (2-CNPh)OCH2
G2-298 2-CF3Ph (3-CNPh)OCH2
G2-299 2-CF3Ph (4-CNPh)OCH2
G2-300 2-CF3Ph (2-N02Ph)OCH2
G2-301 2-CF3Ph (3-N02Ph)OCH2
G2-302 2-CF3Ph (4-N02Ph)OCH2
G2-303 2-CF3Ph (2-CF3Ph)OCH2
G2-304 2-CF3Ph (3-CF3Ph)OCH2
G2-305 2-CF3Ph (4-CF3Ph)OCH2
G2-306 2-CF3Ph PhCH2OCH2
G2-307 2-CF3Ph (2-CH3Ph)CH2OCH2
G2-308 2-CF3Ph (3-CH3Ph)CH2OCH2
G2-309 2-CF3Ph (4-CH3Ph)CH2OCH2
G2-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G2-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G2-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G2-313 2-CF3Ph (2-FPh)CH2OCH2
G2-314 2-CF3Ph (3-FPh)CH2OCH2
G2-315 2-CF3Ph (4-FPh)CH2OCH2
G2-316 2-CF3Ph (2-CIPh)CH2OCH2
G2-317 2-CF3Ph (3-CIPh)CH2OCH2
G2-318 2-CF3Ph (4-CIPh)CH2OCH2
G2-319 2-CF3Ph (2-BrPh)CH2OCH2
G2-320 2-CF3Ph (3-BrPh)CH2OCH2
G2-321 2-CF3Ph (4-BrPh)CH2OCH2
G2-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G2-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G2-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G2-325 2-CF3Ph (2-CNPh)CH2OCH2
G2-326 2-CF3Ph (3-CNPh)CH2OCH2
G2-327 2-CF3Ph (4-CNPh)CH2OCH2
G2-328 2-CF3Ph (2-N02Ph)CH2OCH2
G2-329 2-CF3Ph (3-N02Ph)CH2OCH2
G2-330 2-CF3Ph (4-N02Ph)CH2OCH2
G2-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G2-332 2-CF3Ph (3-CF3Ph)CH2OCH2
G2-333 2-CF3Ph (4-CF3Ph)CH2OCH2
G2-334 2-CF3Ph CH3C(=0)OCH2
G2-335 2-CF3Ph CH3CH2C(=0)OCH2
G2-336 2-CF3Ph CH(CH3)2C(=0)OCH2
G2-337 2-CF3Ph (CH3)3C(=0)OCH2
G2-338 2-CF3Ph (CH3)3CCH2(=0)OCH2
G2-339 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G2-340 2-CF3Ph CF3C(=0)OCH2
G2-341 2-CF3Ph CF3CF2C(=0)OCH2
G2-342 2-CF3Ph (c-hex)C(=0)OCH2
G2-435 3-CF3Ph PhCH2OCH2
G2-436 3-CF3Ph (2-CH3Ph)CH2OCH2
G2-437 3-CF3Ph (3-CH3Ph)CH2OCH2
G2-438 3-CF3Ph (4-CH3Ph)CH2OCH2
G2-439 3-CF3Ph (2-CH3OPh)CH2OCH2
G2-440 3-CF3Ph (3-CH3OPh)CH2OCH2
G2-441 3-CF3Ph (4-CH3OPh)CH2OCH2
G2-442 3-CF3Ph (2-FPh)CH2OCH2
G2-443 3-CF3Ph (3-FPh)CH2OCH2
G2-444 3-CF3Ph (4-FPh)CH2OCH2
G2-445 3-CF3Ph (2-CIPh)CH2OCH2
G2-446 3-CF3Ph (3-CIPh)CH2OCH2
G2-447 3-CF3Ph (4-CIPh)CH2OCH2
G2-448 3-CF3Ph (2-BrPh)CH2OCH2
G2-449 3-CF3Ph (3-BrPh)CH2OCH2
G2-450 3-CF3Ph (4-BrPh)CH2OCH2
G2-451 3-CF3Ph (2-CF3OPh)CH2OCH2
G2-452 3-CF3Ph (3-CF3OPh)CH2OCH2
G2-453 3-CF3Ph (4-CF3OPh)CH2OCH2
G2-454 3-CF3Ph (2-CNPh)CH2OCH2
G2-455 3-CF3Ph (3-CNPh)CH2OCH2
G2-456 3-CF3Ph (4-CNPh)CH2OCH2
G2-457 3-CF3Ph (2-N02Ph)CH2OCH2
G2-458 3-CF3Ph (3-N02Ph)CH2OCH2
G2-459 3-CF3Ph (4-N02Ph)CH2OCH2
G2-460 3-CF3Ph (2-CF3Ph)CH2OCH2
G2-461 3-CF3Ph (3-CF3Ph)CH2OCH2
G2-462 3-CF3Ph (4-CF3Ph)CH2OCH2
G2-463 3-CF3Ph CH3C(=0)OCH2
G2-464 3-CF3Ph CH3CH2C(=0)OCH2
G2-465 3-CF3Ph CH(CH3)2C(=0)OCH2
G2-466 3-CF3Ph (CH3)3C(=0)OCH2
G2-467 3-CF3Ph (CH3)3CCH2(=0)OCH2
G2-468 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G2-469 3-CF3Ph CF3C(=0)OCH2
G2-470 3-CF3Ph CF3CF2C(=0)OCH2
G2-471 3-CF3Ph (c-hex)C(=0)OCH2
G2-472 3-CF3Ph PhC(=0)OCH2
G2-473 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G2-474 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G2-475 3-CF3Ph (4-CH3Ph)C(=0)OCH2
G2-476 3-CF3Ph (2-CH3OPh)C(=0)OCH2
G2-477 3-CF3Ph (3-CH3OPh)C(=0)OCH2
G2-478 3-CF3Ph (4-CH3OPh)C(=0)OCH2
G2-479 3-CF3Ph (2-FPh)C(=0)OCH2
G2-480 3-CF3Ph (3-FPh)C(=0)OCH2
G2-481 3-CF3Ph (4-FPh)C(=0)OCH2
G2-572 4-CF3Ph (3-FPh)CH2OCH2
G2-573 4-CF3Ph (4-FPh)CH2OCH2
G2-574 4-CF3Ph (2-CIPh)CH2OCH2
G2-575 4-CF3Ph (3-CIPh)CH2OCH2
G2-576 4-CF3Ph (4-CIPh)CH2OCH2
G2-577 4-CF3Ph (2-BrPh)CH2OCH2
G2-578 4-CF3Ph (3-BrPh)CH2OCH2
G2-579 4-CF3Ph (4-BrPh)CH2OCH2
G2-580 4-CF3Ph (2-CF3OPh)CH2OCH2
G2-581 4-CF3Ph (3-CF3OPh)CH2OCH2
G2-582 4-CF3Ph (4-CF3OPh)CH2OCH2
G2-583 4-CF3Ph (2-CNPh)CH2OCH2
G2-584 4-CF3Ph (3-CNPh)CH2OCH2
G2-585 4-CF3Ph (4-CNPh)CH2OCH2
G2-586 4-CF3Ph (2-N02Ph)CH2OCH2
G2-587 4-CF3Ph (3-N02Ph)CH2OCH2
G2-588 4-CF3Ph (4-N02Ph)CH2OCH2
G2-589 4-CF3Ph (2-CF3Ph)CH2OCH2
G2-590 4-CF3Ph (3-CF3Ph)CH2OCH2
G2-591 4-CF3Ph (4-CF3Ph)CH2OCH2
G2-592 4-CF3Ph CH3C(=0)OCH2
G2-593 4-CF3Ph CH3CH2C(=0)OCH2
G2-594 4-CF3Ph CH(CH3)2C(=0)OCH2
G2-595 4-CF3Ph (CH3)3C(=0)OCH2
G2-596 4-CF3Ph (CH3)3CCH2(=0)OCH2
G2-597 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G2-598 4-CF3Ph CF3C(=0)OCH2
G2-599 4-CF3Ph CF3CF2C(=0)OCH2
G2-600 4-CF3Ph (c-hex)C(=0)OCH2
G2-601 4-CF3Ph PhC(=0)OCH2
G2-602 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G2-603 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G2-604 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G2-605 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G2-606 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G2-607 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G2-608 4-CF3Ph (2-FPh)C(=0)OCH2
G2-609 4-CF3Ph (3-FPh)C(=0)OCH2
G2-610 4-CF3Ph (4-FPh)C(=0)OCH2
G2-611 4-CF3Ph (2-CIPh)C(=0)OCH2
G2-612 4-CF3Ph (3-CIPh)C(=0)OCH2
G2-613 4-CF3Ph (4-CIPh)C(=0)OCH2
G2-614 4-CF3Ph (2-BrPh)C(=0)OCH2
G2-615 4-CF3Ph (3-BrPh)C(=0)OCH2
G2-616 4-CF3Ph (4-BrPh)C(=0)OCH2
G2-617 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G2-618 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G2-662 3,5-(CF3)2Ph (CH3)3CCH20CH2
G2-663 3,5-(CF3)2Ph CH3CH2C(CH3)2OCH2
G2-664 3,5-(CF3)2Ph (c-hex)OCH2
G2-665 3,5-(CF3)2Ph PhOCH2
G2-666 3,5-(CF3)2Ph (2-CH3Ph)OCH2
G2-667 3,5-(CF3)2Ph (3-CH3Ph)OCH2
G2-668 3,5-(CF3)2Ph (4-CH3Ph)OCH2
G2-669 3,5-(CF3)2Ph (2-CH3OPh)OCH2
G2-670 3,5-(CF3)2Ph (3-CH3OPh)OCH2
G2-671 3,5-(CF3)2Ph (4-CH3OPh)OCH2
G2-672 3,5-(CF3)2Ph (2-FPh)OCH2
G2-673 3,5-(CF3)2Ph (3-FPh)OCH2
G2-674 3,5-(CF3)2Ph (4-FPh)OCH2
G2-675 3,5-(CF3)2Ph (2-CIPh)OCH2
G2-676 3,5-(CF3)2Ph (3-CIPh)OCH2
G2-677 3,5-(CF3)2Ph (4-CIPh)OCH2
G2-678 3,5-(CF3)2Ph (2-BrPh)OCH2
G2-679 3,5-(CF3)2Ph (3-BrPh)OCH2
G2-680 3,5-(CF3)2Ph (4-BrPh)OCH2
G2-681 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G2-682 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G2-683 3,5-(CF3)2Ph (4-CF3OPh)OCH2
G2-684 3,5-(CF3)2Ph (2-CNPh)OCH2
G2-685 3,5-(CF3)2Ph (3-CNPh)OCH2
G2-686 3,5-(CF3)2Ph (4-CNPh)OCH2
G2-687 3,5-(CF3)2Ph (2-N02Ph)OCH2
G2-688 3,5-(CF3)2Ph (3-N02Ph)OCH2
G2-689 3,5-(CF3)2Ph (4-N02Ph)OCH2
G2-690 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G2-691 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G2-692 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G2-693 3,5-(CF3)2Ph PhCH2OCH2
G2-694 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G2-695 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G2-696 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G2-697 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G2-698 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G2-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G2-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G2-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G2-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G2-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G2-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G2-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G2-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G2-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G2-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G2-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G2-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G2-711 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G2-712 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G2-713 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G2-714 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G2-715 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G2-716 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G2-717 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G2-718 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G2-719 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G2-720 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G2-721 3,5-(CF3)2Ph CH3C(=0)OCH2
G2-722 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G2-723 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G2-724 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G2-725 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G2-726 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G2-727 3,5-(CF3)2Ph CF3C(=0)OCH2
G2-728 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G2-729 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G2-730 3,5-(CF3)2Ph PhC(=0)OCH2
G2-731 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G2-732 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G2-733 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G2-734 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G2-735 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G2-736 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G2-737 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G2-738 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G2-739 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G2-740 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G2-741 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G2-742 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G2-743 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G2-744 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G2-745 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G2-746 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G2-747 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G2-748 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G2-749 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G2-750 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G2-751 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G2-752 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G2-753 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G2-754 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G2-755 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G2-756 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G2-757 I 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0296] Table 3
G3-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G3-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G3-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G3-313 2-CF3Ph (2-FPh)CH2OCH2
G3-314 2-CF3Ph (3-FPh)CH2OCH2
G3-315 2-CF3Ph (4-FPh)CH2OCH2
G3-316 2-CF3Ph (2-CIPh)CH2OCH2
G3-317 2-CF3Ph (3-CIPh)CH2OCH2
G3-318 2-CF3Ph (4-CIPh)CH2OCH2
G3-319 2-CF3Ph (2-BrPh)CH2OCH2
G3-320 2-CF3Ph (3-BrPh)CH2OCH2
G3-321 2-CF3Ph (4-BrPh)CH2OCH2
G3-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G3-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G3-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G3-325 2-CF3Ph (2-CNPh)CH2OCH2
G3-326 2-CF3Ph (3-CNPh)CH2OCH2
G3-327 2-CF3Ph (4-CNPh)CH2OCH2
G3-328 2-CF3Ph (2-N02Ph)CH2OCH2
G3-329 2-CF3Ph (3-N02Ph)CH2OCH2
G3-330 2-CF3Ph (4-N02Ph)CH2OCH2
G3-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G3-332 2-CF3Ph (3-CF3Ph)CH2OCH2
G3-333 2-CF3Ph (4-CF3Ph)CH2OCH2
G3-334 2-CF3Ph CH3C(=0)OCH2
G3-335 2-CF3Ph CH3CH2C(=0)OCH2
G3-336 2-CF3Ph CH(CH3)2C(=0)OCH2
G3-337 2-CF3Ph (CH3)3C(=0)OCH2
G3-338 2-CF3Ph (CH3)3CCH2(=0)OCH2
G3-339 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G3-340 2-CF3Ph CF3C(=0)OCH2
G3-341 2-CF3Ph CF3CF2C(=0)OCH2
G3-342 2-CF3Ph (c-hex)C(=0)OCH2
G3-343 2-CF3Ph PhC(=0)OCH2
G3-344 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G3-345 2-CF3Ph (3-CH3Ph)C(=0)OCH2
G3-346 2-CF3Ph (4-CH3Ph)C(=0)OCH2
G3-347 2-CF3Ph (2-CH3OPh)C(=0)OCH2
G3-348 2-CF3Ph (3-CH3OPh)C(=0)OCH2
G3-349 2-CF3Ph (4-CH3OPh)C(=0)OCH2
G3-350 2-CF3Ph (2-FPh)C(=0)OCH2
G3-351 2-CF3Ph (3-FPh)C(=0)OCH2
G3-352 2-CF3Ph (4-FPh)C(=0)OCH2
G3-353 2-CF3Ph (2-CIPh)C(=0)OCH2
G3-354 2-CF3Ph (3-CIPh)C(=0)OCH2
G3-355 2-CF3Ph (4-CIPh)C(=0)OCH2
G3-356 2-CF3Ph (2-BrPh)C(=0)OCH2
G3-446 3-CF3Ph (3-CIPh)CH2OCH2
G3-447 3-CF3Ph (4-CIPh)CH2OCH2
G3-448 3-CF3Ph (2-BrPh)CH2OCH2
G3-449 3-CF3Ph (3-BrPh)CH2OCH2
G3-450 3-CF3Ph (4-BrPh)CH2OCH2
G3-451 3-CF3Ph (2-CF3OPh)CH2OCH2
G3-452 3-CF3Ph (3-CF3OPh)CH2OCH2
G3-453 3-CF3Ph (4-CF3OPh)CH2OCH2
G3-454 3-CF3Ph (2-CNPh)CH2OCH2
G3-455 3-CF3Ph (3-CNPh)CH2OCH2
G3-456 3-CF3Ph (4-CNPh)CH2OCH2
G3-457 3-CF3Ph (2-N02Ph)CH2OCH2
G3-458 3-CF3Ph (3-N02Ph)CH2OCH2
G3-459 3-CF3Ph (4-N02Ph)CH2OCH2
G3-460 3-CF3Ph (2-CF3Ph)CH2OCH2
G3-461 3-CF3Ph (3-CF3Ph)CH2OCH2
G3-462 3-CF3Ph (4-CF3Ph)CH2OCH2
G3-463 3-CF3Ph CH3C(=0)OCH2
G3-464 3-CF3Ph CH3CH2C(=0)OCH2
G3-465 3-CF3Ph CH(CH3)2C(=0)OCH2
G3-466 3-CF3Ph (CH3)3C(=0)OCH2
G3-467 3-CF3Ph (CH3)3CCH2(=0)OCH2
G3-468 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G3-469 3-CF3Ph CF3C(=0)OCH2
G3-470 3-CF3Ph CF3CF2C(=0)OCH2
G3-471 3-CF3Ph (c-hex)C(=0)OCH2
G3-472 3-CF3Ph PhC(=0)OCH2
G3-473 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G3-474 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G3-475 3-CF3Ph (4-CH3Ph)C(=0)OCH2
G3-476 3-CF3Ph (2-CH3OPh)C(=0)OCH2
G3-477 3-CF3Ph (3-CH3OPh)C(=0)OCH2
G3-478 3-CF3Ph (4-CH3OPh)C(=0)OCH2
G3-479 3-CF3Ph (2-FPh)C(=0)OCH2
G3-480 3-CF3Ph (3-FPh)C(=0)OCH2
G3-481 3-CF3Ph (4-FPh)C(=0)OCH2
G3-482 3-CF3Ph (2-CIPh)C(=0)OCH2
G3-483 3-CF3Ph (3-CIPh)C(=0)OCH2
G3-484 3-CF3Ph (4-CIPh)C(=0)OCH2
G3-485 3-CF3Ph (2-BrPh)C(=0)OCH2
G3-486 3-CF3Ph (3-BrPh)C(=0)OCH2
G3-487 3-CF3Ph (4-BrPh)C(=0)OCH2
G3-488 3-CF3Ph (2-CF3OPh)C(=0)OCH2
G3-489 3-CF3Ph (3-CF3OPh)C(=0)OCH2
G3-490 3-CF3Ph (4-CF3OPh)C(=0)OCH2
G3-491 3-CF3Ph (2-CNPh)C(=0)OCH2
G3-492 3-CF3Ph (3-CNPh)C(=0)OCH2
G3-536 4-CF3Ph PhOCH2
G3-537 4-CF3Ph (2-CH3Ph)OCH2
G3-538 4-CF3Ph (3-CH3Ph)OCH2
G3-539 4-CF3Ph (4-CH3Ph)OCH2
G3-540 4-CF3Ph (2-CH3OPh)OCH2
G3-541 4-CF3Ph (3-CH3OPh)OCH2
G3-542 4-CF3Ph (4-CH3OPh)OCH2
G3-543 4-CF3Ph (2-FPh)OCH2
G3-544 4-CF3Ph (3-FPh)OCH2
G3-545 4-CF3Ph (4-FPh)OCH2
G3-546 4-CF3Ph (2-CIPh)OCH2
G3-547 4-CF3Ph (3-CIPh)OCH2
G3-548 4-CF3Ph (4-CIPh)OCH2
G3-549 4-CF3Ph (2-BrPh)OCH2
G3-550 4-CF3Ph (3-BrPh)OCH2
G3-551 4-CF3Ph (4-BrPh)OCH2
G3-552 4-CF3Ph (2-CF3OPh)OCH2
G3-553 4-CF3Ph (3-CF3OPh)OCH2
G3-554 4-CF3Ph (4-CF3OPh)OCH2
G3-555 4-CF3Ph (2-CNPh)OCH2
G3-556 4-CF3Ph (3-CNPh)OCH2
G3-557 4-CF3Ph (4-CNPh)OCH2
G3-558 4-CF3Ph (2-N02Ph)OCH2
G3-559 4-CF3Ph (3-N02Ph)OCH2
G3-560 4-CF3Ph (4-N02Ph)OCH2
G3-561 4-CF3Ph (2-CF3Ph)OCH2
G3-562 4-CF3Ph (3-CF3Ph)OCH2
G3-563 4-CF3Ph (4-CF3Ph)OCH2
G3-564 4-CF3Ph PhCH2OCH2
G3-565 4-CF3Ph (2-CH3Ph)CH2OCH2
G3-566 4-CF3Ph (3-CH3Ph)CH2OCH2
G3-567 4-CF3Ph (4-CH3Ph)CH2OCH2
G3-568 4-CF3Ph (2-CH3OPh)CH2OCH2
G3-569 4-CF3Ph (3-CH3OPh)CH2OCH2
G3-570 4-CF3Ph (4-CH3OPh)CH2OCH2
G3-571 4-CF3Ph (2-FPh)CH2OCH2
G3-572 4-CF3Ph (3-FPh)CH2OCH2
G3-573 4-CF3Ph (4-FPh)CH2OCH2
G3-574 4-CF3Ph (2-CIPh)CH2OCH2
G3-575 4-CF3Ph (3-CIPh)CH2OCH2
G3-576 4-CF3Ph (4-CIPh)CH2OCH2
G3-577 4-CF3Ph (2-BrPh)CH2OCH2
G3-578 4-CF3Ph (3-BrPh)CH2OCH2
G3-579 4-CF3Ph (4-BrPh)CH2OCH2
G3-580 4-CF3Ph (2-CF3OPh)CH2OCH2
G3-581 4-CF3Ph (3-CF3OPh)CH2OCH2
G3-582 4-CF3Ph (4-CF3OPh)CH2OCH2
G3-583 4-CF3Ph (2-CNPh)CH2OCH2
G3-584 4-CF3Ph (3-CNPh)CH2OCH2
G3-585 4-CF3Ph (4-CNPh)CH2OCH2
G3-586 4-CF3Ph (2-N02Ph)CH2OCH2
G3-587 4-CF3Ph (3-N02Ph)CH2OCH2
G3-588 4-CF3Ph (4-N02Ph)CH2OCH2
G3-589 4-CF3Ph (2-CF3Ph)CH2OCH2
G3-590 4-CF3Ph (3-CF3Ph)CH2OCH2
G3-591 4-CF3Ph (4-CF3Ph)CH2OCH2
G3-592 4-CF3Ph CH3C(=0)OCH2
G3-593 4-CF3Ph CH3CH2C(=0)OCH2
G3-594 4-CF3Ph CH(CH3)2C(=0)OCH2
G3-595 4-CF3Ph (CH3)3C(=0)OCH2
G3-596 4-CF3Ph (CH3)3CCH2(=0)OCH2
G3-597 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G3-598 4-CF3Ph CF3C(=0)OCH2
G3-599 4-CF3Ph CF3CF2C(=0)OCH2
G3-600 4-CF3Ph (c-hex)C(=0)OCH2
G3-601 4-CF3Ph PhC(=0)OCH2
G3-602 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G3-603 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G3-604 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G3-605 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G3-606 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G3-607 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G3-608 4-CF3Ph (2-FPh)C(=0)OCH2
G3-609 4-CF3Ph (3-FPh)C(=0)OCH2
G3-610 4-CF3Ph (4-FPh)C(=0)OCH2
G3-611 4-CF3Ph (2-CIPh)C(=0)OCH2
G3-612 4-CF3Ph (3-CIPh)C(=0)OCH2
G3-613 4-CF3Ph (4-CIPh)C(=0)OCH2
G3-614 4-CF3Ph (2-BrPh)C(=0)OCH2
G3-615 4-CF3Ph (3-BrPh)C(=0)OCH2
G3-616 4-CF3Ph (4-BrPh)C(=0)OCH2
G3-617 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G3-618 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G3-619 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G3-620 4-CF3Ph (2-CNPh)C(=0)OCH2
G3-621 4-CF3Ph (3-CNPh)C(=0)OCH2
G3-622 4-CF3Ph (4-CNPh)C(=0)OCH2
G3-623 4-CF3Ph (2-N02Ph)C(=0)OCH2
G3-624 4-CF3Ph (3-N02Ph)C(=0)OCH2
G3-625 4-CF3Ph (4-N02Ph)C(=0)OCH2
G3-626 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G3-627 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G3-628 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G3-629 3,5-(CF3)2Ph CH3
G3-630 3,5-(CF3)2Ph CH3CH2
G3-674 3,5-(CF3)2Ph (4-FPh)OCH2
G3-675 3,5-(CF3)2Ph (2-CIPh)OCH2
G3-676 3,5-(CF3)2Ph (3-CIPh)OCH2
G3-677 3,5-(CF3)2Ph (4-CIPh)OCH2
G3-678 3,5-(CF3)2Ph (2-BrPh)OCH2
G3-679 3,5-(CF3)2Ph (3-BrPh)OCH2
G3-680 3,5-(CF3)2Ph (4-BrPh)OCH2
G3-681 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G3-682 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G3-683 3,5-(CF3)2Ph (4-CF3OPh)OCH2
G3-684 3,5-(CF3)2Ph (2-CNPh)OCH2
G3-685 3,5-(CF3)2Ph (3-CNPh)OCH2
G3-686 3,5-(CF3)2Ph (4-CNPh)OCH2
G3-687 3,5-(CF3)2Ph (2-N02Ph)OCH2
G3-688 3,5-(CF3)2Ph (3-N02Ph)OCH2
G3-689 3,5-(CF3)2Ph (4-N02Ph)OCH2
G3-690 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G3-691 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G3-692 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G3-693 3,5-(CF3)2Ph PhCH2OCH2
G3-694 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G3-695 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G3-696 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G3-697 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G3-698 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G3-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G3-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G3-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G3-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G3-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G3-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G3-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G3-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G3-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G3-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G3-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G3-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G3-711 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G3-712 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G3-713 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G3-714 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G3-715 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G3-716 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G3-717 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G3-718 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G3-719 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G3-720 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G3-721 3,5-(CF3)2Ph CH3C(=0)OCH2
G3-722 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G3-723 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G3-724 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G3-725 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G3-726 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G3-727 3,5-(CF3)2Ph CF3C(=0)OCH2
G3-728 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G3-729 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G3-730 3,5-(CF3)2Ph PhC(=0)OCH2
G3-731 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G3-732 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G3-733 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G3-734 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G3-735 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G3-736 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G3-737 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G3-738 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G3-739 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G3-740 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G3-741 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G3-742 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G3-743 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G3-744 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G3-745 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G3-746 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G3-747 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G3-748 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G3-749 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G3-750 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G3-751 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G3-752 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G3-753 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G3-754 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G3-755 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G3-756 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G3-757 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
G4-134 3-CF3CF2Ph H CH3
G4-135 4-CF3CF2Ph H CH3
G4-136 2-CF3OPh H CH3
G4-137 3-CF3OPh H CH3
G4-138 4-CF3OPh H CH3
G4-139 2-CF3CH2OPh H CH3
G4-140 3-CF3CH2OPh H CH3
G4-141 4-CF3CH2OPh H CH3
G4-142 2-CF3-3-F-Ph H CH3
G4-143 2-CF3-4-F-Ph H CH3
G4-144 2-CF3-5-F-Ph H CH3
G4-145 2-CF3-6-F-Ph H CH3
G4-146 2-CF3-3-CI-Ph H CH3
G4-147 2-CF3-4-CI-Ph H CH3
G4-148 2-CF3-5-CI-Ph H CH3
G4-149 2-CF3-6-CI-Ph H CH3
G4-150 2-CF3-3-CH3-Ph H CH3
G4-151 2-CF3-4-CH3-Ph H CH3
G4-152 2-CF3-5-CH3-Ph H CH3
G4-153 2-CF3-6-CH3-Ph H CH3
G4-154 2,3-(CF3)2Ph H CH3
G4-155 2,4-(CF3)2Ph H CH3
G4-156 2,6-(CF3)2Ph H CH3
G4-157 3,5-(CF3)2Ph H CH3
G4-158 2-CF3-3-CN-Ph H CH3
G4-159 2-CF3-4-CNPh H CH3
G4-160 2-CF3-5-CN-Ph H CH3
G4-161 2-CF3-6-CN-Ph H CH3
G4-162 PhO H CH3
G4-163 2-CF3PhO H CH3
G4-164 3-CF3PhO H CH3
G4-165 4-CF3PhO H CH3
G4-166 2-CF3CF2PhO H CH3
G4-167 3-CF3CF2PhO H CH3
G4-168 4-CF3CF2PhO H CH3
G4-169 2-CF3OPhO H CH3
G4-170 3-CF3OPhO H CH3
G4-171 4-CF3OPhO H CH3
G4-172 2-CF3-3-F-PhO H CH3
G4-173 2-CF3-4-F-PhO H CH3
G4-174 2-CF3-5-F-PhO H CH3
G4-175 2-CF3-6-F-PhO H CH3
G4-176 2-CF3-3-CI-PhO H CH3
G4-177 2-CF3-4-CI-PhO H CH3
G4-178 2-CF3-5-CI-PhO H CH3
G4-179 2-CF3-6-CI-PhO H CH3
G4-180 2-CF3-3-CH3-PhO H CH3
G4-181 2-CF3-4-CH3-PhO H CH3
G4-182 2-CF3-5-CH3-PhO H CH3
G4-183 2-CF3-6-CH3-PhO H CH3
G4-184 2,3-(CF3)2PhO H CH3
G4-185 2,4-(CF3)2PhO H CH3
G4-186 2,6-(CF3)2PhO H CH3
G4-187 3,5-(CF3)2PhO H CH3
G4-188 PhCH20 H CH3
G4-189 2-CF3PhCH20 H CH3
G4-190 3-CF3PhCH20 H CH3
G4-191 4-CF3PhCH20 H CH3
G4-192 2-CF3CF2PhCH20 H CH3
G4-193 3-CF3CF2PhCH20 H CH3
G4-194 4-CF3CF2PhCH20 H CH3
G4-195 2-CF3OPhCH20 H CH3
G4-196 3-CF3OPhCH20 H CH3
G4-197 4-CF3OPhCH20 H CH3
G4-198 2-CF3-3-F-PhCH20 H CH3
G4-199 2-CF3-4-F-PhCH20 H CH3
G4-200 2-CF3-5-F-PhCH20 H CH3
G4-201 2-CF3-6-F-PhCH20 H CH3
G4-202 2-CF3-3-CI-PhCH20 H CH3
G4-203 2-CF3-4-CI-PhCH20 H CH3
G4-204 2-CF3-5-CI-PhCH20 H CH3
G4-205 2-CF3-6-CI-PhCH20 H CH3
G4-206 2-CF3-3-CH3-PhCH20 H CH3
G4-207 2-CF3-4-CH3-PhCH20 H CH3
G4-208 2-CF3-5-CH3-PhCH20 H CH3
G4-209 2-CF3-6-CH3-PhCH20 H CH3
G4-210 2,3-(CF3)2PhCH20 H CH3
G4-211 2,4-(CF3)2PhCH20 H CH3
G4-212 2,6-(CF3)2PhCH20 H CH3
G4-213 3,5-(CF3)2PhCH20 H CH3
G4-214 PhS H CH3
G4-215 2-CF3PhS H CH3
G4-216 3-CF3PhS H CH3
G4-217 4-CF3PhS H CH3
G4-218 PhNCH3 H CH3
G4-219 2-CF3PhNCH3 H CH3
G4-220 3-CF3PhNCH3 H CH3
G4-221 4-CF3PhNCH3 H CH3
G4-222 2-Pyridyl H CH3
G4-223 3-Pyridyl H CH3
G4-224 4-Pyridyl H CH3
G4-225 CF3 CH3 H
G4-226 CF3 CH3CH2 H
G4-270 CF3 (4-FPh)OCH2 H
G4-271 CF3 (2-CIPh)OCH2 H
G4-272 CF3 (3-CIPh)OCH2 H
G4-273 CF3 (4-CIPh)OCH2 H
G4-274 CF3 (2-BrPh)OCH2 H
G4-275 CF3 (3-BrPh)OCH2 H
G4-276 CF3 (4-BrPh)OCH2 H
G4-277 CF3 (2-CF3OPh)OCH2 H
G4-278 CF3 (3-CF3OPh)OCH2 H
G4-279 CF3 (4-CF3OPh)OCH2 H
G4-280 CF3 (2-CNPh)OCH2 H
G4-281 CF3 (3-CNPh)OCH2 H
G4-282 CF3 (4-CNPh)OCH2 H
G4-283 CF3 (2-N02Ph)OCH2 H
G4-284 CF3 (3-N02Ph)OCH2 H
G4-285 CF3 (4-N02Ph)OCH2 H
G4-286 CF3 (2-CF3Ph)OCH2 H
G4-287 CF3 (3-CF3Ph)OCH2 H
G4-288 CF3 (4-CF3Ph)OCH2 H
G4-289 CF3 PhCH2OCH2 H
G4-290 CF3 (2-CH3Ph)CH2OCH2 H
G4-291 CF3 (3-CH3Ph)CH2OCH2 H
G4-292 CF3 (4-CH3Ph)CH2OCH2 H
G4-293 CF3 (2-CH3OPh)CH2OCH2 H
G4-294 CF3 (3-CH3OPh)CH2OCH2 H
G4-295 CF3 (4-CH3OPh)CH2OCH2 H
G4-296 CF3 (2-FPh)CH2OCH2 H
G4-297 CF3 (3-FPh)CH2OCH2 H
G4-298 CF3 (4-FPh)CH2OCH2 H
G4-299 CF3 (2-CIPh)CH2OCH2 H
G4-300 CF3 (3-CIPh)CH2OCH2 H
G4-301 CF3 (4-CIPh)CH2OCH2 H
G4-302 CF3 (2-BrPh)CH2OCH2 H
G4-303 CF3 (3-BrPh)CH2OCH2 H
G4-304 CF3 (4-BrPh)CH2OCH2 H
G4-305 CF3 (2-CF3OPh)CH2OCH2 H
G4-306 CF3 (3-CF3OPh)CH2OCH2 H
G4-307 CF3 (4-CF3OPh)CH2OCH2 H
G4-308 CF3 (2-CNPh)CH2OCH2 H
G4-309 CF3 (3-CNPh)CH2OCH2 H
G4-310 CF3 (4-CNPh)CH2OCH2 H
G4-311 CF3 (2-N02Ph)CH2OCH2 H
G4-312 CF3 (3-N02Ph)CH2OCH2 H
G4-313 CF3 (4-N02Ph)CH2OCH2 H
G4-314 CF3 (2-CF3Ph)CH2OCH2 H
G4-315 CF3 (3-CF3Ph)CH2OCH2 H
G4-408 CF3 (4-CF3OPh)OCH2 CH3
G4-409 CF3 (2-CNPh)OCH2 CH3
G4-410 CF3 (3-CNPh)OCH2 CH3
G4-411 CF3 (4-CNPh)OCH2 CH3
G4-412 CF3 (2-N02Ph)OCH2 CH3
G4-413 CF3 (3-N02Ph)OCH2 CH3
G4-414 CF3 (4-N02Ph)OCH2 CH3
G4-415 CF3 (2-CF3Ph)OCH2 CH3
G4-416 CF3 (3-CF3Ph)OCH2 CH3
G4-417 CF3 (4-CF3Ph)OCH2 CH3
G4-418 CF3 PhCH2OCH2 CH3
G4-419 CF3 (2-CH3Ph)CH2OCH2 CH3
G4-420 CF3 (3-CH3Ph)CH2OCH2 CH3
G4-421 CF3 (4-CH3Ph)CH2OCH2 CH3
G4-422 CF3 (2-CH3OPh)CH2OCH2 CH3
G4-423 CF3 (3-CH3OPh)CH2OCH2 CH3
G4-424 CF3 (4-CH3OPh)CH2OCH2 CH3
G4-425 CF3 (2-FPh)CH2OCH2 CH3
G4-426 CF3 (3-FPh)CH2OCH2 CH3
G4-427 CF3 (4-FPh)CH2OCH2 CH3
G4-428 CF3 (2-CIPh)CH2OCH2 CH3
G4-429 CF3 (3-CIPh)CH2OCH2 CH3
G4-430 CF3 (4-CIPh)CH2OCH2 CH3
G4-431 CF3 (2-BrPh)CH2OCH2 CH3
G4-432 CF3 (3-BrPh)CH2OCH2 CH3
G4-433 CF3 (4-BrPh)CH2OCH2 CH3
G4-434 CF3 (2-CF3OPh)CH2OCH2 CH3
G4-435 CF3 (3-CF3OPh)CH2OCH2 CH3
G4-436 CF3 (4-CF3OPh)CH2OCH2 CH3
G4-437 CF3 (2-CNPh)CH2OCH2 CH3
G4-438 CF3 (3-CNPh)CH2OCH2 CH3
G4-439 CF3 (4-CNPh)CH2OCH2 CH3
G4-440 CF3 (2-N02Ph)CH2OCH2 CH3
G4-441 CF3 (3-N02Ph)CH2OCH2 CH3
G4-442 CF3 (4-N02Ph)CH2OCH2 CH3
G4-443 CF3 (2-CF3Ph)CH2OCH2 CH3
G4-444 CF3 (3-CF3Ph)CH2OCH2 CH3
G4-445 CF3 (4-CF3Ph)CH2OCH2 CH3
G4-446 CF3 CH3C(=0)OCH2 CH3
G4-447 CF3 CH3CH2C(=0)OCH2 CH3
G4-448 CF3 CH(CH3)2C(=0)OCH2 CH3
G4-449 CF3 (CH3)3C(=0)OCH2 CH3
G4-450 CF3 (CH3)3CCH2(=0)OCH2 CH3
G4-451 CF3 CH3CH2C(CH3)2C(=0)OCH2 CH3
G4-452 CF3 CF3C(=0)OCH2 CH3
G4-453 CF3 CF3CF2C(=0)OCH2 CH3
G4-546 2-CF3Ph (4-CF3Ph)OCH2 H
G4-547 2-CF3Ph PhCH2OCH2 H
G4-548 2-CF3Ph (2-CH3Ph)CH2OCH2 H
G4-549 2-CF3Ph (3-CH3Ph)CH2OCH2 H
G4-550 2-CF3Ph (4-CH3Ph)CH2OCH2 H
G4-551 2-CF3Ph (2-CH3OPh)CH2OCH2 H
G4-552 2-CF3Ph (3-CH3OPh)CH2OCH2 H
G4-553 2-CF3Ph (4-CH3OPh)CH2OCH2 H
G4-554 2-CF3Ph (2-FPh)CH2OCH2 H
G4-555 2-CF3Ph (3-FPh)CH2OCH2 H
G4-556 2-CF3Ph (4-FPh)CH2OCH2 H
G4-557 2-CF3Ph (2-CIPh)CH2OCH2 H
G4-558 2-CF3Ph (3-CIPh)CH2OCH2 H
G4-559 2-CF3Ph (4-CIPh)CH2OCH2 H
G4-560 2-CF3Ph (2-BrPh)CH2OCH2 H
G4-561 2-CF3Ph (3-BrPh)CH2OCH2 H
G4-562 2-CF3Ph (4-BrPh)CH2OCH2 H
G4-563 2-CF3Ph (2-CF3OPh)CH2OCH2 H
G4-564 2-CF3Ph (3-CF3OPh)CH2OCH2 H
G4-565 2-CF3Ph (4-CF3OPh)CH2OCH2 H
G4-566 2-CF3Ph (2-CNPh)CH2OCH2 H
G4-567 2-CF3Ph (3-CNPh)CH2OCH2 H
G4-568 2-CF3Ph (4-CNPh)CH2OCH2 H
G4-569 2-CF3Ph (2-N02Ph)CH2OCH2 H
G4-570 2-CF3Ph (3-N02Ph)CH2OCH2 H
G4-571 2-CF3Ph (4-N02Ph)CH2OCH2 H
G4-572 2-CF3Ph (2-CF3Ph)CH2OCH2 H
G4-573 2-CF3Ph (3-CF3Ph)CH2OCH2 H
G4-574 2-CF3Ph (4-CF3Ph)CH2OCH2 H
G4-575 2-CF3Ph CH3C(=0)OCH2 H
G4-576 2-CF3Ph CH3CH2C(=0)OCH2 H
G4-577 2-CF3Ph CH(CH3)2C(=0)OCH2 H
G4-578 2-CF3Ph (CH3)3C(=0)OCH2 H
G4-579 2-CF3Ph (CH3)3CCH2(=0)OCH2 H
G4-580 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G4-581 2-CF3Ph CF3C(=0)OCH2 H
G4-582 2-CF3Ph CF3CF2C(=0)OCH2 H
G4-583 2-CF3Ph (c-hex)C(=0)OCH2 H
G4-584 2-CF3Ph PhC(=0)OCH2 H
G4-585 2-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G4-586 2-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G4-587 2-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G4-588 2-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G4-589 2-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G4-590 2-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G4-591 2-CF3Ph (2-FPh)C(=0)OCH2 H
G4-592 2-CF3Ph (3-FPh)C(=0)OCH2 H
G4-593 2-CF3Ph (4-FPh)C(=0)OCH2 H
G4-594 2-CF3Ph (2-CIPh)C(=0)OCH2 H
G4-595 2-CF3Ph (3-CIPh)C(=0)OCH2 H
G4-596 2-CF3Ph (4-CIPh)C(=0)OCH2 H
G4-597 2-CF3Ph (2-BrPh)C(=0)OCH2 H
G4-598 2-CF3Ph (3-BrPh)C(=0)OCH2 H
G4-599 2-CF3Ph (4-BrPh)C(=0)OCH2 H
G4-600 2-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G4-601 2-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G4-602 2-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G4-603 2-CF3Ph (2-CNPh)C(=0)OCH2 H
G4-604 2-CF3Ph (3-CNPh)C(=0)OCH2 H
G4-605 2-CF3Ph (4-CNPh)C(=0)OCH2 H
G4-606 2-CF3Ph (2-N02Ph)C(=0)OCH2 H
G4-607 2-CF3Ph (3-N02Ph)C(=0)OCH2 H
G4-608 2-CF3Ph (4-N02Ph)C(=0)OCH2 H
G4-609 2-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G4-610 2-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G4-611 2-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G4-612 2-CF3Ph CH3 CH3
G4-613 2-CF3Ph CH3CH2 CH3
G4-614 2-CF3Ph CH3CH2CH2 CH3
G4-615 2-CF3Ph (CH3)2CH CH3
G4-616 2-CF3Ph CH3C(=0) CH3
G4-617 2-CF3Ph CH3CH2C(=0) CH3
G4-618 2-CF3Ph (CH3)2CHC(=0) CH3
G4-619 2-CF3Ph (CH3)3CC(=0) CH3
G4-620 2-CF3Ph (CH3)3CCH2C(=0) CH3
G4-621 2-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G4-622 2-CF3Ph (CH3)2CHCH2C(=0) CH3
G4-623 2-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G4-624 2-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G4-625 2-CF3Ph (c-hex)C(=0) CH3
G4-626 2-CF3Ph (c-pen)C(=0) CH3
G4-627 2-CF3Ph (c-hep)C(=0) CH3
G4-628 2-CF3Ph (c-pro)C(=0) CH3
G4-629 2-CF3Ph CF3C(=0) CH3
G4-630 2-CF3Ph (CH3)2NC(=0) CH3
G4-631 2-CF3Ph (CH3CH2)2NC(=0) CH3
G4-632 2-CF3Ph (CH3CH2CH2)2NC(=0) CH3
G4-633 2-CF3Ph CH3CH2N(CH3)C(=0) CH3
G4-634 2-CF3Ph [(CH3)2CHCH2]2NC(=0) CH3
G4-635 2-CF3Ph CH3ON(CH3)C(=0) CH3
G4-636 2-CF3Ph (CH2=CHCH2)2N C(=0) CH3
G4-637 2-CF3Ph (CHCCH2)2NC(=0) CH3
G4-684 2-CF3Ph (3-FPh)CH2OCH2 CH3
G4-685 2-CF3Ph (4-FPh)CH2OCH2 CH3
G4-686 2-CF3Ph (2-CIPh)CH2OCH2 CH3
G4-687 2-CF3Ph (3-CIPh)CH2OCH2 CH3
G4-688 2-CF3Ph (4-CIPh)CH2OCH2 CH3
G4-689 2-CF3Ph (2-BrPh)CH2OCH2 CH3
G4-690 2-CF3Ph (3-BrPh)CH2OCH2 CH3
G4-691 2-CF3Ph (4-BrPh)CH2OCH2 CH3
G4-692 2-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G4-693 2-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G4-694 2-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G4-695 2-CF3Ph (2-CNPh)CH2OCH2 CH3
G4-696 2-CF3Ph (3-CNPh)CH2OCH2 CH3
G4-697 2-CF3Ph (4-CNPh)CH2OCH2 CH3
G4-698 2-CF3Ph (2-N02Ph)CH2OCH2 CH3
G4-699 2-CF3Ph (3-N02Ph)CH2OCH2 CH3
G4-700 2-CF3Ph (4-N02Ph)CH2OCH2 CH3
G4-701 2-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G4-702 2-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G4-703 2-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G4-704 2-CF3Ph CH3C(=0)OCH2 CH3
G4-705 2-CF3Ph CH3CH2C(=0)OCH2 CH3
G4-706 2-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G4-707 2-CF3Ph (CH3)3C(=0)OCH2 CH3
G4-708 2-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G4-709 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G4-710 2-CF3Ph CF3C(=0)OCH2 CH3
G4-711 2-CF3Ph CF3CF2C(=0)OCH2 CH3
G4-712 2-CF3Ph (c-hex)C(=0)OCH2 CH3
G4-713 2-CF3Ph PhC(=0)OCH2 CH3
G4-714 2-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G4-715 2-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G4-716 2-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G4-717 2-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G4-718 2-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G4-719 2-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G4-720 2-CF3Ph (2-FPh)C(=0)OCH2 CH3
G4-721 2-CF3Ph (3-FPh)C(=0)OCH2 CH3
G4-722 2-CF3Ph (4-FPh)C(=0)OCH2 CH3
G4-723 2-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G4-724 2-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G4-725 2-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G4-726 2-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G4-727 2-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G4-728 2-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G4-729 2-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G4-774 3-CF3Ph (CH3)3CCH20CH2 H
G4-775 3-CF3Ph CH3CH2C(CH3)2OCH2 H
G4-776 3-CF3Ph (c-hex)OCH2 H
G4-777 3-CF3Ph PhOCH2 H
G4-778 3-CF3Ph (2-CH3Ph)OCH2 H
G4-779 3-CF3Ph (3-CH3Ph)OCH2 H
G4-780 3-CF3Ph (4-CH3Ph)OCH2 H
G4-781 3-CF3Ph (2-CH3OPh)OCH2 H
G4-782 3-CF3Ph (3-CH3OPh)OCH2 H
G4-783 3-CF3Ph (4-CH3OPh)OCH2 H
G4-784 3-CF3Ph (2-FPh)OCH2 H
G4-785 3-CF3Ph (3-FPh)OCH2 H
G4-786 3-CF3Ph (4-FPh)OCH2 H
G4-787 3-CF3Ph (2-CIPh)OCH2 H
G4-788 3-CF3Ph (3-CIPh)OCH2 H
G4-789 3-CF3Ph (4-CIPh)OCH2 H
G4-790 3-CF3Ph (2-BrPh)OCH2 H
G4-791 3-CF3Ph (3-BrPh)OCH2 H
G4-792 3-CF3Ph (4-BrPh)OCH2 H
G4-793 3-CF3Ph (2-CF3OPh)OCH2 H
G4-794 3-CF3Ph (3-CF3OPh)OCH2 H
G4-795 3-CF3Ph (4-CF3OPh)OCH2 H
G4-796 3-CF3Ph (2-CNPh)OCH2 H
G4-797 3-CF3Ph (3-CNPh)OCH2 H
G4-798 3-CF3Ph (4-CNPh)OCH2 H
G4-799 3-CF3Ph (2-N02Ph)OCH2 H
G4-800 3-CF3Ph (3-N02Ph)OCH2 H
G4-801 3-CF3Ph (4-N02Ph)OCH2 H
G4-802 3-CF3Ph (2-CF3Ph)OCH2 H
G4-803 3-CF3Ph (3-CF3Ph)OCH2 H
G4-804 3-CF3Ph (4-CF3Ph)OCH2 H
G4-805 3-CF3Ph PhCH2OCH2 H
G4-806 3-CF3Ph (2-CH3Ph)CH2OCH2 H
G4-807 3-CF3Ph (3-CH3Ph)CH2OCH2 H
G4-808 3-CF3Ph (4-CH3Ph)CH2OCH2 H
G4-809 3-CF3Ph (2-CH3OPh)CH2OCH2 H
G4-810 3-CF3Ph (3-CH3OPh)CH2OCH2 H
G4-81 1 3-CF3Ph (4-CH3OPh)CH2OCH2 H
G4-812 3-CF3Ph (2-FPh)CH2OCH2 H
G4-813 3-CF3Ph (3-FPh)CH2OCH2 H
G4-814 3-CF3Ph (4-FPh)CH2OCH2 H
G4-815 3-CF3Ph (2-CIPh)CH2OCH2 H
G4-816 3-CF3Ph (3-CIPh)CH2OCH2 H
G4-817 3-CF3Ph (4-CIPh)CH2OCH2 H
G4-818 3-CF3Ph (2-BrPh)CH2OCH2 H
G4-819 3-CF3Ph (3-BrPh)CH2OCH2 H
G4-820 3-CF3Ph (4-BrPh)CH2OCH2 H
G4-821 3-CF3Ph (2-CF3OPh)CH2OCH2 H
G4-822 3-CF3Ph (3-CF3OPh)CH2OCH2 H
G4-823 3-CF3Ph (4-CF3OPh)CH2OCH2 H
G4-824 3-CF3Ph (2-CNPh)CH2OCH2 H
G4-825 3-CF3Ph (3-CNPh)CH2OCH2 H
G4-826 3-CF3Ph (4-CNPh)CH2OCH2 H
G4-827 3-CF3Ph (2-N02Ph)CH2OCH2 H
G4-828 3-CF3Ph (3-N02Ph)CH2OCH2 H
G4-829 3-CF3Ph (4-N02Ph)CH2OCH2 H
G4-830 3-CF3Ph (2-CF3Ph)CH2OCH2 H
G4-831 3-CF3Ph (3-CF3Ph)CH2OCH2 H
G4-832 3-CF3Ph (4-CF3Ph)CH2OCH2 H
G4-833 3-CF3Ph CH3C(=0)OCH2 H
G4-834 3-CF3Ph CH3CH2C(=0)OCH2 H
G4-835 3-CF3Ph CH(CH3)2C(=0)OCH2 H
G4-836 3-CF3Ph (CH3)3C(=0)OCH2 H
G4-837 3-CF3Ph (CH3)3CCH2(=0)OCH2 H
G4-838 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G4-839 3-CF3Ph CF3C(=0)OCH2 H
G4-840 3-CF3Ph CF3CF2C(=0)OCH2 H
G4-841 3-CF3Ph (c-hex)C(=0)OCH2 H
G4-842 3-CF3Ph PhC(=0)OCH2 H
G4-843 3-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G4-844 3-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G4-845 3-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G4-846 3-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G4-847 3-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G4-848 3-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G4-849 3-CF3Ph (2-FPh)C(=0)OCH2 H
G4-850 3-CF3Ph (3-FPh)C(=0)OCH2 H
G4-851 3-CF3Ph (4-FPh)C(=0)OCH2 H
G4-852 3-CF3Ph (2-CIPh)C(=0)OCH2 H
G4-853 3-CF3Ph (3-CIPh)C(=0)OCH2 H
G4-854 3-CF3Ph (4-CIPh)C(=0)OCH2 H
G4-855 3-CF3Ph (2-BrPh)C(=0)OCH2 H
G4-856 3-CF3Ph (3-BrPh)C(=0)OCH2 H
G4-857 3-CF3Ph (4-BrPh)C(=0)OCH2 H
G4-858 3-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G4-859 3-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G4-860 3-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G4-861 3-CF3Ph (2-CNPh)C(=0)OCH2 H
G4-862 3-CF3Ph (3-CNPh)C(=0)OCH2 H
G4-863 3-CF3Ph (4-CNPh)C(=0)OCH2 H
G4-864 3-CF3Ph (2-N02Ph)C(=0)OCH2 H
G4-865 3-CF3Ph (3-N02Ph)C(=0)OCH2 H
G4-866 3-CF3Ph (4-N02Ph)C(=0)OCH2 H
G4-867 3-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G4-868 3-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G4-912 3-CF3Ph (4-CH3OPh)OCH2 CH3
G4-913 3-CF3Ph (2-FPh)OCH2 CH3
G4-914 3-CF3Ph (3-FPh)OCH2 CH3
G4-915 3-CF3Ph (4-FPh)OCH2 CH3
G4-916 3-CF3Ph (2-CIPh)OCH2 CH3
G4-917 3-CF3Ph (3-CIPh)OCH2 CH3
G4-918 3-CF3Ph (4-CIPh)OCH2 CH3
G4-919 3-CF3Ph (2-BrPh)OCH2 CH3
G4-920 3-CF3Ph (3-BrPh)OCH2 CH3
G4-921 3-CF3Ph (4-BrPh)OCH2 CH3
G4-922 3-CF3Ph (2-CF3OPh)OCH2 CH3
G4-923 3-CF3Ph (3-CF3OPh)OCH2 CH3
G4-924 3-CF3Ph (4-CF3OPh)OCH2 CH3
G4-925 3-CF3Ph (2-CNPh)OCH2 CH3
G4-926 3-CF3Ph (3-CNPh)OCH2 CH3
G4-927 3-CF3Ph (4-CNPh)OCH2 CH3
G4-928 3-CF3Ph (2-N02Ph)OCH2 CH3
G4-929 3-CF3Ph (3-N02Ph)OCH2 CH3
G4-930 3-CF3Ph (4-N02Ph)OCH2 CH3
G4-931 3-CF3Ph (2-CF3Ph)OCH2 CH3
G4-932 3-CF3Ph (3-CF3Ph)OCH2 CH3
G4-933 3-CF3Ph (4-CF3Ph)OCH2 CH3
G4-934 3-CF3Ph PhCH2OCH2 CH3
G4-935 3-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G4-936 3-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G4-937 3-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G4-938 3-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G4-939 3-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G4-940 3-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G4-941 3-CF3Ph (2-FPh)CH2OCH2 CH3
G4-942 3-CF3Ph (3-FPh)CH2OCH2 CH3
G4-943 3-CF3Ph (4-FPh)CH2OCH2 CH3
G4-944 3-CF3Ph (2-CIPh)CH2OCH2 CH3
G4-945 3-CF3Ph (3-CIPh)CH2OCH2 CH3
G4-946 3-CF3Ph (4-CIPh)CH2OCH2 CH3
G4-947 3-CF3Ph (2-BrPh)CH2OCH2 CH3
G4-948 3-CF3Ph (3-BrPh)CH2OCH2 CH3
G4-949 3-CF3Ph (4-BrPh)CH2OCH2 CH3
G4-950 3-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G4-951 3-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G4-952 3-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G4-953 3-CF3Ph (2-CNPh)CH2OCH2 CH3
G4-954 3-CF3Ph (3-CNPh)CH2OCH2 CH3
G4-955 3-CF3Ph (4-CNPh)CH2OCH2 CH3
G4-956 3-CF3Ph (2-N02Ph)CH2OCH2 CH3
G4-957 3-CF3Ph (3-N02Ph)CH2OCH2 CH3
G4-958 3-CF3Ph (4-N02Ph)CH2OCH2 CH3
G4-959 3-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G4-960 3-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G4-961 3-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G4-962 3-CF3Ph CH3C(=0)OCH2 CH3
G4-963 3-CF3Ph CH3CH2C(=0)OCH2 CH3
G4-964 3-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G4-965 3-CF3Ph (CH3)3C(=0)OCH2 CH3
G4-966 3-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G4-967 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G4-968 3-CF3Ph CF3C(=0)OCH2 CH3
G4-969 3-CF3Ph CF3CF2C(=0)OCH2 CH3
G4-970 3-CF3Ph (c-hex)C(=0)OCH2 CH3
G4-971 3-CF3Ph PhC(=0)OCH2 CH3
G4-972 3-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G4-973 3-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G4-974 3-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G4-975 3-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G4-976 3-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G4-977 3-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G4-978 3-CF3Ph (2-FPh)C(=0)OCH2 CH3
G4-979 3-CF3Ph (3-FPh)C(=0)OCH2 CH3
G4-980 3-CF3Ph (4-FPh)C(=0)OCH2 CH3
G4-981 3-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G4-982 3-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G4-983 3-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G4-984 3-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G4-985 3-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G4-986 3-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G4-987 3-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G4-988 3-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G4-989 3-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G4-990 3-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G4-991 3-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G4-992 3-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G4-993 3-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G4-994 3-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G4-995 3-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G4-996 3-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G4-997 3-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G4-998 3-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G4-999 4-CF3Ph CH3 H
G4-1000 4-CF3Ph CH3CH2 H
G4-1001 4-CF3Ph CH3CH2CH2 H
G4-1002 4-CF3Ph (CH3)2CH H
G4-1003 4-CF3Ph CH3C(=0) H
G4-1004 4-CF3Ph CH3CH2C(=0) H
G4-1005 4-CF3Ph (CH3)2CHC(=0) H
G4-1006 4-CF3Ph (CH3)3CC(=0) H
G4-1050 4-CF3Ph (4-BrPh)OCH2 H
G4-1051 4-CF3Ph (2-CF3OPh)OCH2 H
G4-1052 4-CF3Ph (3-CF3OPh)OCH2 H
G4-1053 4-CF3Ph (4-CF3OPh)OCH2 H
G4-1054 4-CF3Ph (2-CNPh)OCH2 H
G4-1055 4-CF3Ph (3-CNPh)OCH2 H
G4-1056 4-CF3Ph (4-CNPh)OCH2 H
G4-1057 4-CF3Ph (2-N02Ph)OCH2 H
G4-1058 4-CF3Ph (3-N02Ph)OCH2 H
G4-1059 4-CF3Ph (4-N02Ph)OCH2 H
G4-1060 4-CF3Ph (2-CF3Ph)OCH2 H
G4-1061 4-CF3Ph (3-CF3Ph)OCH2 H
G4-1062 4-CF3Ph (4-CF3Ph)OCH2 H
G4-1063 4-CF3Ph PhCH2OCH2 H
G4-1064 4-CF3Ph (2-CH3Ph)CH2OCH2 H
G4-1065 4-CF3Ph (3-CH3Ph)CH2OCH2 H
G4-1066 4-CF3Ph (4-CH3Ph)CH2OCH2 H
G4-1067 4-CF3Ph (2-CH3OPh)CH2OCH2 H
G4-1068 4-CF3Ph (3-CH3OPh)CH2OCH2 H
G4-1069 4-CF3Ph (4-CH3OPh)CH2OCH2 H
G4-1070 4-CF3Ph (2-FPh)CH2OCH2 H
G4-1071 4-CF3Ph (3-FPh)CH2OCH2 H
G4-1072 4-CF3Ph (4-FPh)CH2OCH2 H
G4-1073 4-CF3Ph (2-CIPh)CH2OCH2 H
G4-1074 4-CF3Ph (3-CIPh)CH2OCH2 H
G4-1075 4-CF3Ph (4-CIPh)CH2OCH2 H
G4-1076 4-CF3Ph (2-BrPh)CH2OCH2 H
G4-1077 4-CF3Ph (3-BrPh)CH2OCH2 H
G4-1078 4-CF3Ph (4-BrPh)CH2OCH2 H
G4-1079 4-CF3Ph (2-CF3OPh)CH2OCH2 H
G4-1080 4-CF3Ph (3-CF3OPh)CH2OCH2 H
G4-1081 4-CF3Ph (4-CF3OPh)CH2OCH2 H
G4-1082 4-CF3Ph (2-CNPh)CH2OCH2 H
G4-1083 4-CF3Ph (3-CNPh)CH2OCH2 H
G4-1084 4-CF3Ph (4-CNPh)CH2OCH2 H
G4-1085 4-CF3Ph (2-N02Ph)CH2OCH2 H
G4-1086 4-CF3Ph (3-N02Ph)CH2OCH2 H
G4-1087 4-CF3Ph (4-N02Ph)CH2OCH2 H
G4-1088 4-CF3Ph (2-CF3Ph)CH2OCH2 H
G4-1089 4-CF3Ph (3-CF3Ph)CH2OCH2 H
G4-1090 4-CF3Ph (4-CF3Ph)CH2OCH2 H
G4-1091 4-CF3Ph CH3C(=0)OCH2 H
G4-1092 4-CF3Ph CH3CH2C(=0)OCH2 H
G4-1093 4-CF3Ph CH(CH3)2C(=0)OCH2 H
G4-1094 4-CF3Ph (CH3)3C(=0)OCH2 H
G4-1095 4-CF3Ph (CH3)3CCH2(=0)OCH2 H
G4-1096 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G4-1097 4-CF3Ph CF3C(=0)OCH2 H
G4-1098 4-CF3Ph CF3CF2C(=0)OCH2 H
G4-1099 4-CF3Ph (c-hex)C(=0)OCH2 H
G4-1100 4-CF3Ph PhC(=0)OCH2 H
G4-1101 4-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G4-1102 4-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G4-1103 4-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G4-1104 4-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G4-1105 4-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G4-1106 4-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G4-1107 4-CF3Ph (2-FPh)C(=0)OCH2 H
G4-1108 4-CF3Ph (3-FPh)C(=0)OCH2 H
G4-1109 4-CF3Ph (4-FPh)C(=0)OCH2 H
G4-1110 4-CF3Ph (2-CIPh)C(=0)OCH2 H
G4-1111 4-CF3Ph (3-CIPh)C(=0)OCH2 H
G4-1112 4-CF3Ph (4-CIPh)C(=0)OCH2 H
G4-1113 4-CF3Ph (2-BrPh)C(=0)OCH2 H
G4-1114 4-CF3Ph (3-BrPh)C(=0)OCH2 H
G4-1115 4-CF3Ph (4-BrPh)C(=0)OCH2 H
G4-1116 4-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G4-1117 4-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G4-1118 4-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G4-1119 4-CF3Ph (2-CNPh)C(=0)OCH2 H
G4-1120 4-CF3Ph (3-CNPh)C(=0)OCH2 H
G4-1121 4-CF3Ph (4-CNPh)C(=0)OCH2 H
G4-1122 4-CF3Ph (2-N02Ph)C(=0)OCH2 H
G4-1123 4-CF3Ph (3-N02Ph)C(=0)OCH2 H
G4-1124 4-CF3Ph (4-N02Ph)C(=0)OCH2 H
G4-1125 4-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G4-1126 4-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G4-1127 4-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G4-1128 4-CF3Ph CH3 CH3
G4-1129 4-CF3Ph CH3CH2 CH3
G4-1130 4-CF3Ph CH3CH2CH2 CH3
G4-1131 4-CF3Ph (CH3)2CH CH3
G4-1132 4-CF3Ph CH3C(=0) CH3
G4-1133 4-CF3Ph CH3CH2C(=0) CH3
G4-1134 4-CF3Ph (CH3)2CHC(=0) CH3
G4-1135 4-CF3Ph (CH3)3CC(=0) CH3
G4-1136 4-CF3Ph (CH3)3CCH2C(=0) CH3
G4-1137 4-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G4-1138 4-CF3Ph (CH3)2CHCH2C(=0) CH3
G4-1139 4-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G4-1140 4-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G4-1141 4-CF3Ph (c-hex)C(=0) CH3
G4-1142 4-CF3Ph (c-pen)C(=0) CH3
G4-1143 4-CF3Ph (c-hep)C(=0) CH3
G4-1144 4-CF3Ph (c-pro)C(=0) CH3
G4-1188 4-CF3Ph (4-N02Ph)OCH2 CH3
G4-1189 4-CF3Ph (2-CF3Ph)OCH2 CH3
G4-1190 4-CF3Ph (3-CF3Ph)OCH2 CH3
G4-1191 4-CF3Ph (4-CF3Ph)OCH2 CH3
G4-1192 4-CF3Ph PhCH2OCH2 CH3
G4-1193 4-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G4-1194 4-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G4-1195 4-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G4-1196 4-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G4-1197 4-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G4-1198 4-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G4-1199 4-CF3Ph (2-FPh)CH2OCH2 CH3
G4-1200 4-CF3Ph (3-FPh)CH2OCH2 CH3
G4-1201 4-CF3Ph (4-FPh)CH2OCH2 CH3
G4-1202 4-CF3Ph (2-CIPh)CH2OCH2 CH3
G4-1203 4-CF3Ph (3-CIPh)CH2OCH2 CH3
G4-1204 4-CF3Ph (4-CIPh)CH2OCH2 CH3
G4-1205 4-CF3Ph (2-BrPh)CH2OCH2 CH3
G4-1206 4-CF3Ph (3-BrPh)CH2OCH2 CH3
G4-1207 4-CF3Ph (4-BrPh)CH2OCH2 CH3
G4-1208 4-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G4-1209 4-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G4-1210 4-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G4-1211 4-CF3Ph (2-CNPh)CH2OCH2 CH3
G4-1212 4-CF3Ph (3-CNPh)CH2OCH2 CH3
G4-1213 4-CF3Ph (4-CNPh)CH2OCH2 CH3
G4-1214 4-CF3Ph (2-N02Ph)CH2OCH2 CH3
G4-1215 4-CF3Ph (3-N02Ph)CH2OCH2 CH3
G4-1216 4-CF3Ph (4-N02Ph)CH2OCH2 CH3
G4-1217 4-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G4-1218 4-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G4-1219 4-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G4-1220 4-CF3Ph CH3C(=0)OCH2 CH3
G4-1221 4-CF3Ph CH3CH2C(=0)OCH2 CH3
G4-1222 4-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G4-1223 4-CF3Ph (CH3)3C(=0)OCH2 CH3
G4-1224 4-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G4-1225 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G4-1226 4-CF3Ph CF3C(=0)OCH2 CH3
G4-1227 4-CF3Ph CF3CF2C(=0)OCH2 CH3
G4-1228 4-CF3Ph (c-hex)C(=0)OCH2 CH3
G4-1229 4-CF3Ph PhC(=0)OCH2 CH3
G4-1230 4-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G4-1231 4-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G4-1232 4-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G4-1233 4-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G4-1234 4-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G4-1235 4-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G4-1236 4-CF3Ph (2-FPh)C(=0)OCH2 CH3
G4-1237 4-CF3Ph (3-FPh)C(=0)OCH2 CH3
G4-1238 4-CF3Ph (4-FPh)C(=0)OCH2 CH3
G4-1239 4-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G4-1240 4-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G4-1241 4-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G4-1242 4-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G4-1243 4-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G4-1244 4-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G4-1245 4-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G4-1246 4-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G4-1247 4-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G4-1248 4-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G4-1249 4-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G4-1250 4-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G4-1251 4-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G4-1252 4-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G4-1253 4-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G4-1254 4-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G4-1255 4-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G4-1256 4-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G4-1257 3,5-(CF3)2Ph CH3 H
G4-1258 3,5-(CF3)2Ph CH3CH2 H
G4-1259 3,5-(CF3)2Ph CH3CH2CH2 H
G4-1260 3,5-(CF3)2Ph (CH3)2CH H
G4-1261 3,5-(CF3)2Ph CH3C(=0) H
G4-1262 3,5-(CF3)2Ph CH3CH2C(=0) H
G4-1263 3,5-(CF3)2Ph (CH3)2CHC(=0) H
G4-1264 3,5-(CF3)2Ph (CH3)3CC(=0) H
G4-1265 3,5-(CF3)2Ph (CH3)3CCH2C(=0) H
G4-1266 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0) H
G4-1267 3,5-(CF3)2Ph (CH3)2CHCH2C(=0) H
G4-1268 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0) H
G4-1269 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0) H
G4-1270 3,5-(CF3)2Ph (c-hex)C(=0) H
G4-1271 3,5-(CF3)2Ph (c-pen)C(=0) H
G4-1272 3,5-(CF3)2Ph (c-hep)C(=0) H
G4-1273 3,5-(CF3)2Ph (c-pro)C(=0) H
G4-1274 3,5-(CF3)2Ph CF3C(=0) H
G4-1275 3,5-(CF3)2Ph (CH3)2NC(=0) H
G4-1276 3,5-(CF3)2Ph (CH3CH2)2NC(=0) H
G4-1277 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0) H
G4-1278 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0) H
G4-1279 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0) H
G4-1280 3,5-(CF3)2Ph CH3ON(CH3)C(=0) H
G4-1281 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0) H
G4-1326 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 H
G4-1327 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 H
G4-1328 3,5-(CF3)2Ph (2-FPh)CH2OCH2 H
G4-1329 3,5-(CF3)2Ph (3-FPh)CH2OCH2 H
G4-1330 3,5-(CF3)2Ph (4-FPh)CH2OCH2 H
G4-1331 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 H
G4-1332 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 H
G4-1333 3,5-(CF3)2P (4-CIPh)CH2OCH2 H
G4-1334 3,5-(CF3)2Ph (2-BrPh)CH2OCH2 H
G4-1335 3,5-(CF3)2Ph (3-BrPh)CH2OCH2 H
G4-1336 3,5-(CF3)2Ph (4-BrPh)CH2OCH2 H
G4-1337 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2 H
G4-1338 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2 H
G4-1339 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2 H
G4-1340 3,5-(CF3)2Ph (2-CNPh)CH2OCH2 H
G4-1341 3,5-(CF3)2Ph (3-CNPh)CH2OCH2 H
G4-1342 3,5-(CF3)2Ph (4-CNPh)CH2OCH2 H
G4-1343 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2 H
G4-1344 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2 H
G4-1345 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2 H
G4-1346 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2 H
G4-1347 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2 H
G4-1348 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2 H
G4-1349 3,5-(CF3)2Ph CH3C(=0)OCH2 H
G4-1350 3,5-(CF3)2Ph CH3CH2C(=0)OCH2 H
G4-1351 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2 H
G4-1352 3,5-(CF3)2Ph (CH3)3C(=0)OCH2 H
G4-1353 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2 H
G4-1354 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2 H
G4-1355 3,5-(CF3)2Ph CF3C(=0)OCH2 H
G4-1356 3,5-(CF3)2Ph CF3CF2C(=0)OCH2 H
G4-1357 3,5-(CF3)2Ph (c-hex)C(=0)OCH2 H
G4-1358 3,5-(CF3)2Ph PhC(=0)OCH2 H
G4-1359 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2 H
G4-1360 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2 H
G4-1361 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2 H
G4-1362 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2 H
G4-1363 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2 H
G4-1364 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2 H
G4-1365 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2 H
G4-1366 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2 H
G4-1367 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2 H
G4-1368 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2 H
G4-1369 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2 H
G4-1370 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2 H
G4-1371 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2 H
G4-1372 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2 H
G4-1373 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2 H
G4-1374 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2 H
G4-1375 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2 H
G4-1376 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2 H
G4-1377 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2 H
G4-1378 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2 H
G4-1379 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2 H
G4-1380 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2 H
G4-1381 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2 H
G4-1382 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2 H
G4-1383 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2 H
G4-1384 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2 H
G4-1385 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2 H
G4-1386 3,5-(CF3)2Ph CH3 CH3
G4-1387 3,5-(CF3)2Ph CH3CH2 CH3
G4-1388 3,5-(CF3)2Ph CH3CH2CH2 CH3
G4-1389 3,5-(CF3)2Ph (CH3)2CH CH3
G4-1390 3,5-(CF3)2Ph CH3C(=0) CH3
G4-1391 3,5-(CF3)2Ph CH3CH2C(=0) CH3
G4-1392 3,5-(CF3)2Ph (CH3)2CHC(=0) CH3
G4-1393 3,5-(CF3)2Ph (CH3)3CC(=0) CH3
G4-1394 3,5-(CF3)2Ph (CH3)3CCH2C(=0) CH3
G4-1395 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0) CH3
G4-1396 3,5-(CF3)2Ph (CH3)2CHCH2C(=0) CH3
G4-1397 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0) CH3
G4-1398 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0) CH3
G4-1399 3,5-(CF3)2Ph (c-hex)C(=0) CH3
G4-1400 3,5-(CF3)2Ph (c-pen)C(=0) CH3
G4-1401 3,5-(CF3)2Ph (c-hep)C(=0) CH3
G4-1402 3,5-(CF3)2Ph (c-pro)C(=0) CH3
G4-1403 3,5-(CF3)2Ph CF3C(=0) CH3
G4-1404 3,5-(CF3)2Ph (CH3)2NC(=0) CH3
G4-1405 3,5-(CF3)2Ph (CH3CH2)2NC(=0) CH3
G4-1406 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0) CH3
G4-1407 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0) CH3
G4-1408 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0) CH3
G4-1409 3,5-(CF3)2Ph CH3ON(CH3)C(=0) CH3
G4-1410 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0) CH3
G4-1411 3,5-(CF3)2Ph (CHCCH2)2NC(=0) CH3
G4-1412 3,5-(CF3)2Ph CH3
G4-1413 3,5-(CF3)2Ph CH3
G4-1414 3,5-(CF3)2Ph CH3
G4-1415 3,5-(CF3)2Ph CH3OCH2 CH3
G4-1416 3,5-(CF3)2Ph CH3CH2OCH2 CH3
G4-1417 3,5-(CF3)2Ph (CH3)2CHOCH2 CH3
G4-1418 3,5-(CF3)2Ph (CH3)3COCH2 CH3
G4-1419 3,5-(CF3)2Ph (CH3)3CCH20CH2 CH3
G4-1420 3,5-(CF3)2Ph CH3CH2C(CH3)2OCH2 CH3
G4-1421 3,5-(CF3)2Ph (c-hex)OCH2 CH3
G4-1422 3,5-(CF3)2Ph PhOCH2 CH3
G4-1423 3,5-(CF3)2Ph (2-CH3Ph)OCH2 CH3
G4-1424 3,5-(CF3)2Ph (3-CH3Ph)OCH2 CH3
G4-1425 3,5-(CF3)2Ph (4-CH3Ph)OCH2 CH3
G4-1426 3,5-(CF3)2Ph (2-CH3OPh)OCH2 CH3
G4-1427 3,5-(CF3)2Ph (3-CH3OPh)OCH2 CH3
G4-1428 3,5-(CF3)2Ph (4-CH3OPh)OCH2 CH3
G4-1429 3,5-(CF3)2Ph (2-FPh)OCH2 CH3
G4-1430 3,5-(CF3)2Ph (3-FPh)OCH2 CH3
G4-1431 3,5-(CF3)2Ph (4-FPh)OCH2 CH3
G4-1432 3,5-(CF3)2Ph (2-CIPh)OCH2 CH3
G4-1433 3,5-(CF3)2Ph (3-CIPh)OCH2 CH3
G4-1434 3,5-(CF3)2Ph (4-CIPh)OCH2 CH3
G4-1435 3,5-(CF3)2Ph (2-BrPh)OCH2 CH3
G4-1436 3,5-(CF3)2Ph (3-BrPh)OCH2 CH3
G4-1437 3,5-(CF3)2Ph (4-BrPh)OCH2 CH3
G4-1438 3,5-(CF3)2Ph (2-CF3OPh)OCH2 CH3
G4-1439 3,5-(CF3)2Ph (3-CF3OPh)OCH2 CH3
G4-1440 3,5-(CF3)2Ph (4-CF3OPh)OCH2 CH3
G4-1441 3,5-(CF3)2Ph (2-CNPh)OCH2 CH3
G4-1442 3,5-(CF3)2Ph (3-CNPh)OCH2 CH3
G4-1443 3,5-(CF3)2Ph (4-CNPh)OCH2 CH3
G4-1444 3,5-(CF3)2Ph (2-N02Ph)OCH2 CH3
G4-1445 3,5-(CF3)2Ph (3-N02Ph)OCH2 CH3
G4-1446 3,5-(CF3)2Ph (4-N02Ph)OCH2 CH3
G4-1447 3,5-(CF3)2Ph (2-CF3Ph)OCH2 CH3
G4-1448 3,5-(CF3)2Ph (3-CF3Ph)OCH2 CH3
G4-1449 3,5-(CF3)2Ph (4-CF3Ph)OCH2 CH3
G4-1450 3,5-(CF3)2Ph PhCH2OCH2 CH3
G4-1451 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2 CH3
G4-1452 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2 CH3
G4-1453 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2 CH3
G4-1454 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2 CH3
G4-1455 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 CH3
G4-1456 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 CH3
G4-1457 3,5-(CF3)2Ph (2-FPh)CH2OCH2 CH3
G4-1458 3,5-(CF3)2Ph (3-FPh)CH2OCH2 CH3
G4-1459 3,5-(CF3)2Ph (4-FPh)CH2OCH2 CH3
G4-1460 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 CH3
G4-1461 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 CH3
G4-1560 CF3 CH3 4-Pyridyl
G4-1561 CF3 CH3 3-CI-Pyridin-2-yl
G4-1562 CF3 CF3CH2 2-Pyridyl
G4-1563 CF3 CF3CH2 3-Pyridyl
G4-1564 CF3 CF3CH2 4-Pyridyl
G4-1565 CF3 CF3CH2 3-CI-Pyridin-2-yl
[0298] Table 5
G5-124 2-FPh H CH3
G5-125 3-FPh H CH3
G5-126 4-FPh H CH3
G5-127 2-CIPh H CH3
G5-128 3-CIPh H CH3
G5-129 4-CIPh H CH3
G5-130 2-CF3Ph H CH3
G5-131 3-CF3Ph H CH3
G5-132 4-CF3Ph H CH3
G5-133 2-CF3CF2Ph H CH3
G5-134 3-CF3CF2Ph H CH3
G5-135 4-CF3CF2Ph H CH3
G5-136 2-CF3OPh H CH3
G5-137 3-CF3OPh H CH3
G5-138 4-CF3OPh H CH3
G5-139 2-CF3CH2OPh H CH3
G5-140 3-CF3CH2OPh H CH3
G5-141 4-CF3CH2OPh H CH3
G5-142 2-CF3-3-F-Ph H CH3
G5-143 2-CF3-4-F-Ph H CH3
G5-144 2-CF3-5-F-Ph H CH3
G5-145 2-CF3-6-F-Ph H CH3
G5-146 2-CF3-3-CI-Ph H CH3
G5-147 2-CF3-4-CI-Ph H CH3
G5-148 2-CF3-5-CI-Ph H CH3
G5-149 2-CF3-6-CI-Ph H CH3
G5-150 2-CF3-3-CH3-Ph H CH3
G5-151 2-CF3-4-CH3-Ph H CH3
G5-152 2-CF3-5-CH3-Ph H CH3
G5-153 2-CF3-6-CH3-Ph H CH3
G5-154 2,3-(CF3)2Ph H CH3
G5-155 2,4-(CF3)2Ph H CH3
G5-156 2,6-(CF3)2Ph H CH3
G5-157 3,5-(CF3)2Ph H CH3
G5-158 2-CF3-3-CN-Ph H CH3
G5-159 2-CF3-4-CNPh H CH3
G5-160 2-CF3-5-CN-Ph H CH3
G5-161 2-CF3-6-CN-Ph H CH3
G5-162 PhO H CH3
G5-163 2-CF3PhO H CH3
G5-164 3-CF3PhO H CH3
G5-165 4-CF3PhO H CH3
G5-166 2-CF3CF2PhO H CH3
G5-167 3-CF3CF2PhO H CH3
G5-168 4-CF3CF2PhO H CH3
G5-169 2-CF3OPhO H CH3
G5-170 3-CF3OPhO H CH3
G5-171 4-CF3OPhO H CH3
G5-172 2-CF3-3-F-PhO H CH3
G5-173 2-CF3-4-F-PhO H CH3
G5-174 2-CF3-5-F-PhO H CH3
G5-175 2-CF3-6-F-PhO H CH3
G5-176 2-CF3-3-CI-PhO H CH3
G5-177 2-CF3-4-CI-PhO H CH3
G5-178 2-CF3-5-CI-PhO H CH3
G5-179 2-CF3-6-CI-PhO H CH3
G5-180 2-CF3-3-CH3-PhO H CH3
G5-181 2-CF3-4-CH3-PhO H CH3
G5-182 2-CF3-5-CH3-PhO H CH3
G5-183 2-CF3-6-CH3-PhO H CH3
G5-184 2,3-(CF3)2PhO H CH3
G5-185 2,4-(CF3)2PhO H CH3
G5-186 2,6-(CF3)2PhO H CH3
G5-187 3,5-(CF3)2PhO H CH3
G5-188 PhCH20 H CH3
G5-189 2-CF3PhCH20 H CH3
G5-190 3-CF3PhCH20 H CH3
G5-191 4-CF3PhCH20 H CH3
G5-192 2-CF3CF2PhCH20 H CH3
G5-193 3-CF3CF2PhCH20 H CH3
G5-194 4-CF3CF2PhCH20 H CH3
G5-195 2-CF3OPhCH20 H CH3
G5-196 3-CF3OPhCH20 H CH3
G5-197 4-CF3OPhCH20 H CH3
G5-198 2-CF3-3-F-PhCH20 H CH3
G5-199 2-CF3-4-F-PhCH20 H CH3
G5-200 2-CF3-5-F-PhCH20 H CH3
G5-201 2-CF3-6-F-PhCH20 H CH3
G5-202 2-CF3-3-CI-PhCH20 H CH3
G5-203 2-CF3-4-CI-PhCH20 H CH3
G5-204 2-CF3-5-CI-PhCH20 H CH3
G5-205 2-CF3-6-CI-PhCH20 H CH3
G5-206 2-CF3-3-CH3-PhCH20 H CH3
G5-207 2-CF3-4-CH3-PhCH20 H CH3
G5-208 2-CF3-5-CH3-PhCH20 H CH3
G5-209 2-CF3-6-CH3-PhCH20 H CH3
G5-210 2,3-(CF3)2PhCH20 H CH3
G5-21 1 2,4-(CF3)2PhCH20 H CH3
G5-212 2,6-(CF3)2PhCH20 H CH3
G5-213 3,5-(CF3)2PhCH20 H CH3
G5-214 PhS H CH3
G5-215 2-CF3PhS H CH3
G5-216 3-CF3PhS H CH3
G5-260 CF3 (c-hex)OCH2 H
G5-261 CF3 PhOCH2 H
G5-262 CF3 (2-CH3Ph)OCH2 H
G5-263 CF3 (3-CH3Ph)OCH2 H
G5-264 CF3 (4-CH3Ph)OCH2 H
G5-265 CF3 (2-CH3OPh)OCH2 H
G5-266 CF3 (3-CH3OPh)OCH2 H
G5-267 CF3 (4-CH3OPh)OCH2 H
G5-268 CF3 (2-FPh)OCH2 H
G5-269 CF3 (3-FPh)OCH2 H
G5-270 CF3 (4-FPh)OCH2 H
G5-271 CF3 (2-CIPh)OCH2 H
G5-272 CF3 (3-CIPh)OCH2 H
G5-273 CF3 (4-CIPh)OCH2 H
G5-274 CF3 (2-BrPh)OCH2 H
G5-275 CF3 (3-BrPh)OCH2 H
G5-276 CF3 (4-BrPh)OCH2 H
G5-277 CF3 (2-CF3OPh)OCH2 H
G5-278 CF3 (3-CF3OPh)OCH2 H
G5-279 CF3 (4-CF3OPh)OCH2 H
G5-280 CF3 (2-CNPh)OCH2 H
G5-281 CF3 (3-CNPh)OCH2 H
G5-282 CF3 (4-CNPh)OCH2 H
G5-283 CF3 (2-N02Ph)OCH2 H
G5-284 CF3 (3-N02Ph)OCH2 H
G5-285 CF3 (4-N02Ph)OCH2 H
G5-286 CF3 (2-CF3Ph)OCH2 H
G5-287 CF3 (3-CF3Ph)OCH2 H
G5-288 CF3 (4-CF3Ph)OCH2 H
G5-289 CF3 PhCH2OCH2 H
G5-290 CF3 (2-CH3Ph)CH2OCH2 H
G5-291 CF3 (3-CH3Ph)CH2OCH2 H
G5-292 CF3 (4-CH3Ph)CH2OCH2 H
G5-293 CF3 (2-CH3OPh)CH2OCH2 H
G5-294 CF3 (3-CH3OPh)CH2OCH2 H
G5-295 CF3 (4-CH3OPh)CH2OCH2 H
G5-296 CF3 (2-FPh)CH2OCH2 H
G5-297 CF3 (3-FPh)CH2OCH2 H
G5-298 CF3 (4-FPh)CH2OCH2 H
G5-299 CF3 (2-CIPh)CH2OCH2 H
G5-300 CF3 (3-CIPh)CH2OCH2 H
G5-301 CF3 (4-CIPh)CH2OCH2 H
G5-302 CF3 (2-BrPh)CH2OCH2 H
G5-303 CF3 (3-BrPh)CH2OCH2 H
G5-304 CF3 (4-BrPh)CH2OCH2 H
G5-305 CF3 (2-CF3OPh)CH2OCH2 H
G5-306 CF3 (3-CF3OPh)CH2OCH2 H
G5-307 CF3 (4-CF3OPh)CH2OCH2 H
G5-308 CF3 (2-CNPh)CH2OCH2 H
G5-309 CF3 (3-CNPh)CH2OCH2 H
G5-310 CF3 (4-CNPh)CH2OCH2 H
G5-311 CF3 (2-N02Ph)CH2OCH2 H
G5-312 CF3 (3-N02Ph)CH2OCH2 H
G5-313 CF3 (4-N02Ph)CH2OCH2 H
G5-314 CF3 (2-CF3Ph)CH2OCH2 H
G5-315 CF3 (3-CF3Ph)CH2OCH2 H
G5-316 CF3 (4-CF3Ph)CH2OCH2 H
G5-317 CF3 CH3C(=0)OCH2 H
G5-318 CF3 CH3CH2C(=0)OCH2 H
G5-319 CF3 CH(CH3)2C(=0)OCH2 H
G5-320 CF3 (CH3)3C(=0)OCH2 H
G5-321 CF3 (CH3)3CCH2(=0)OCH2 H
G5-322 CF3 CH3CH2C(CH3)2C(=0)OCH2 H
G5-323 CF3 CF3C(=0)OCH2 H
G5-324 CF3 CF3CF2C(=0)OCH2 H
G5-325 CF3 (c-hex)C(=0)OCH2 H
G5-326 CF3 PhC(=0)OCH2 H
G5-327 CF3 (2-CH3Ph)C(=0)OCH2 H
G5-328 CF3 (3-CH3Ph)C(=0)OCH2 H
G5-329 CF3 (4-CH3Ph)C(=0)OCH2 H
G5-330 CF3 (2-CH3OPh)C(=0)OCH2 H
G5-331 CF3 (3-CH3OPh)C(=0)OCH2 H
G5-332 CF3 (4-CH3OPh)C(=0)OCH2 H
G5-333 CF3 (2-FPh)C(=0)OCH2 H
G5-334 CF3 (3-FPh)C(=0)OCH2 H
G5-335 CF3 (4-FPh)C(=0)OCH2 H
G5-336 CF3 (2-CIPh)C(=0)OCH2 H
G5-337 CF3 (3-CIPh)C(=0)OCH2 H
G5-338 CF3 (4-CIPh)C(=0)OCH2 H
G5-339 CF3 (2-BrPh)C(=0)OCH2 H
G5-340 CF3 (3-BrPh)C(=0)OCH2 H
G5-341 CF3 (4-BrPh)C(=0)OCH2 H
G5-342 CF3 (2-CF3OPh)C(=0)OCH2 H
G5-343 CF3 (3-CF3OPh)C(=0)OCH2 H
G5-344 CF3 (4-CF3OPh)C(=0)OCH2 H
G5-345 CF3 (2-CNPh)C(=0)OCH2 H
G5-346 CF3 (3-CNPh)C(=0)OCH2 H
G5-347 CF3 (4-CNPh)C(=0)OCH2 H
G5-348 CF3 (2-N02Ph)C(=0)OCH2 H
G5-349 CF3 (3-N02Ph)C(=0)OCH2 H
G5-350 CF3 (4-N02Ph)C(=0)OCH2 H
G5-351 CF3 (2-CF3Ph)C(=0)OCH2 H
G5-352 CF3 (3-CF3Ph)C(=0)OCH2 H
G5-353 CF3 (4-CF3Ph)C(=0)OCH2 H
G5-354 CF3 CH3 CH3
G5-398 CF3 (3-FPh)OCH2 CH3
G5-399 CF3 (4-FPh)OCH2 CH3
G5-400 CF3 (2-CIPh)OCH2 CH3
G5-401 CF3 (3-CIPh)OCH2 CH3
G5-402 CF3 (4-CIPh)OCH2 CH3
G5-403 CF3 (2-BrPh)OCH2 CH3
G5-404 CF3 (3-BrPh)OCH2 CH3
G5-405 CF3 (4-BrPh)OCH2 CH3
G5-406 CF3 (2-CF3OPh)OCH2 CH3
G5-407 CF3 (3-CF3OPh)OCH2 CH3
G5-408 CF3 (4-CF3OPh)OCH2 CH3
G5-409 CF3 (2-CNPh)OCH2 CH3
G5-410 CF3 (3-CNPh)OCH2 CH3
G5-411 CF3 (4-CNPh)OCH2 CH3
G5-412 CF3 (2-N02Ph)OCH2 CH3
G5-413 CF3 (3-N02Ph)OCH2 CH3
G5-414 CF3 (4-N02Ph)OCH2 CH3
G5-415 CF3 (2-CF3Ph)OCH2 CH3
G5-416 CF3 (3-CF3Ph)OCH2 CH3
G5-417 CF3 (4-CF3Ph)OCH2 CH3
G5-418 CF3 PhCH2OCH2 CH3
G5-419 CF3 (2-CH3Ph)CH2OCH2 CH3
G5-420 CF3 (3-CH3Ph)CH2OCH2 CH3
G5-421 CF3 (4-CH3Ph)CH2OCH2 CH3
G5-422 CF3 (2-CH3OPh)CH2OCH2 CH3
G5-423 CF3 (3-CH3OPh)CH2OCH2 CH3
G5-424 CF3 (4-CH3OPh)CH2OCH2 CH3
G5-425 CF3 (2-FPh)CH2OCH2 CH3
G5-426 CF3 (3-FPh)CH2OCH2 CH3
G5-427 CF3 (4-FPh)CH2OCH2 CH3
G5-428 CF3 (2-CIPh)CH2OCH2 CH3
G5-429 CF3 (3-CIPh)CH2OCH2 CH3
G5-430 CF3 (4-CIPh)CH2OCH2 CH3
G5-431 CF3 (2-BrPh)CH2OCH2 CH3
G5-432 CF3 (3-BrPh)CH2OCH2 CH3
G5-433 CF3 (4-BrPh)CH2OCH2 CH3
G5-434 CF3 (2-CF3OPh)CH2OCH2 CH3
G5-435 CF3 (3-CF3OPh)CH2OCH2 CH3
G5-436 CF3 (4-CF3OPh)CH2OCH2 CH3
G5-437 CF3 (2-CNPh)CH2OCH2 CH3
G5-438 CF3 (3-CNPh)CH2OCH2 CH3
G5-439 CF3 (4-CNPh)CH2OCH2 CH3
G5-440 CF3 (2-N02Ph)CH2OCH2 CH3
G5-441 CF3 (3-N02Ph)CH2OCH2 CH3
G5-442 CF3 (4-N02Ph)CH2OCH2 CH3
G5-443 CF3 (2-CF3Ph)CH2OCH2 CH3
G5-536 2-CF3Ph (3-CF3OPh)OCH2 H
G5-537 2-CF3Ph (4-CF3OPh)OCH2 H
G5-538 2-CF3Ph (2-CNPh)OCH2 H
G5-539 2-CF3Ph (3-CNPh)OCH2 H
G5-540 2-CF3Ph (4-CNPh)OCH2 H
G5-541 2-CF3Ph (2-N02Ph)OCH2 H
G5-542 2-CF3Ph (3-N02Ph)OCH2 H
G5-543 2-CF3Ph (4-N02Ph)OCH2 H
G5-544 2-CF3Ph (2-CF3Ph)OCH2 H
G5-545 2-CF3Ph (3-CF3Ph)OCH2 H
G5-546 2-CF3Ph (4-CF3Ph)OCH2 H
G5-547 2-CF3Ph PhCH2OCH2 H
G5-548 2-CF3Ph (2-CH3Ph)CH2OCH2 H
G5-549 2-CF3Ph (3-CH3Ph)CH2OCH2 H
G5-550 2-CF3Ph (4-CH3Ph)CH2OCH2 H
G5-551 2-CF3Ph (2-CH3OPh)CH2OCH2 H
G5-552 2-CF3Ph (3-CH3OPh)CH2OCH2 H
G5-553 2-CF3Ph (4-CH3OPh)CH2OCH2 H
G5-554 2-CF3Ph (2-FPh)CH2OCH2 H
G5-555 2-CF3Ph (3-FPh)CH2OCH2 H
G5-556 2-CF3Ph (4-FPh)CH2OCH2 H
G5-557 2-CF3Ph (2-CIPh)CH2OCH2 H
G5-558 2-CF3Ph (3-CIPh)CH2OCH2 H
G5-559 2-CF3Ph (4-CIPh)CH2OCH2 H
G5-560 2-CF3Ph (2-BrPh)CH2OCH2 H
G5-561 2-CF3Ph (3-BrPh)CH2OCH2 H
G5-562 2-CF3Ph (4-BrPh)CH2OCH2 H
G5-563 2-CF3Ph (2-CF3OPh)CH2OCH2 H
G5-564 2-CF3Ph (3-CF3OPh)CH2OCH2 H
G5-565 2-CF3Ph (4-CF3OPh)CH2OCH2 H
G5-566 2-CF3Ph (2-CNPh)CH2OCH2 H
G5-567 2-CF3Ph (3-CNPh)CH2OCH2 H
G5-568 2-CF3Ph (4-CNPh)CH2OCH2 H
G5-569 2-CF3Ph (2-N02Ph)CH2OCH2 H
G5-570 2-CF3Ph (3-N02Ph)CH2OCH2 H
G5-571 2-CF3Ph (4-N02Ph)CH2OCH2 H
G5-572 2-CF3Ph (2-CF3Ph)CH2OCH2 H
G5-573 2-CF3Ph (3-CF3Ph)CH2OCH2 H
G5-574 2-CF3Ph (4-CF3Ph)CH2OCH2 H
G5-575 2-CF3Ph CH3C(=0)OCH2 H
G5-576 2-CF3Ph CH3CH2C(=0)OCH2 H
G5-577 2-CF3Ph CH(CH3)2C(=0)OCH2 H
G5-578 2-CF3Ph (CH3)3C(=0)OCH2 H
G5-579 2-CF3Ph (CH3)3CCH2(=0)OCH2 H
G5-580 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G5-581 2-CF3Ph CF3C(=0)OCH2 H
G5-582 2-CF3Ph CF3CF2C(=0)OCH2 H
G5-583 2-CF3Ph (c-hex)C(=0)OCH2 H
G5-584 2-CF3Ph PhC(=0)OCH2 H
G5-585 2-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G5-586 2-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G5-587 2-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G5-588 2-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G5-589 2-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G5-590 2-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G5-591 2-CF3Ph (2-FPh)C(=0)OCH2 H
G5-592 2-CF3Ph (3-FPh)C(=0)OCH2 H
G5-593 2-CF3Ph (4-FPh)C(=0)OCH2 H
G5-594 2-CF3Ph (2-CIPh)C(=0)OCH2 H
G5-595 2-CF3Ph (3-CIPh)C(=0)OCH2 H
G5-596 2-CF3Ph (4-CIPh)C(=0)OCH2 H
G5-597 2-CF3Ph (2-BrPh)C(=0)OCH2 H
G5-598 2-CF3Ph (3-BrPh)C(=0)OCH2 H
G5-599 2-CF3Ph (4-BrPh)C(=0)OCH2 H
G5-600 2-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G5-601 2-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G5-602 2-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G5-603 2-CF3Ph (2-CNPh)C(=0)OCH2 H
G5-604 2-CF3Ph (3-CNPh)C(=0)OCH2 H
G5-605 2-CF3Ph (4-CNPh)C(=0)OCH2 H
G5-606 2-CF3Ph (2-N02Ph)C(=0)OCH2 H
G5-607 2-CF3Ph (3-N02Ph)C(=0)OCH2 H
G5-608 2-CF3Ph (4-N02Ph)C(=0)OCH2 H
G5-609 2-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G5-610 2-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G5-611 2-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G5-612 2-CF3Ph CH3 CH3
G5-613 2-CF3Ph CH3CH2 CH3
G5-614 2-CF3Ph CH3CH2CH2 CH3
G5-615 2-CF3Ph (CH3)2CH CH3
G5-616 2-CF3Ph CH3C(=0) CH3
G5-617 2-CF3Ph CH3CH2C(=0) CH3
G5-618 2-CF3Ph (CH3)2CHC(=0) CH3
G5-619 2-CF3Ph (CH3)3CC(=0) CH3
G5-620 2-CF3Ph (CH3)3CCH2C(=0) CH3
G5-621 2-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G5-622 2-CF3Ph (CH3)2CHCH2C(=0) CH3
G5-623 2-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G5-624 2-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G5-625 2-CF3Ph (c-hex)C(=0) CH3
G5-626 2-CF3Ph (c-pen)C(=0) CH3
G5-627 2-CF3Ph (c-hep)C(=0) CH3
G5-628 2-CF3Ph (c-pro)C(=0) CH3
G5-629 2-CF3Ph CF3C(=0) CH3
G5-674 2-CF3Ph (3-CF3Ph)OCH2 CH3
G5-675 2-CF3Ph (4-CF3Ph)OCH2 CH3
G5-676 2-CF3Ph PhCH2OCH2 CH3
G5-677 2-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G5-678 2-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G5-679 2-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G5-680 2-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G5-681 2-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G5-682 2-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G5-683 2-CF3Ph (2-FPh)CH2OCH2 CH3
G5-684 2-CF3Ph (3-FPh)CH2OCH2 CH3
G5-685 2-CF3Ph (4-FPh)CH2OCH2 CH3
G5-686 2-CF3Ph (2-CIPh)CH2OCH2 CH3
G5-687 2-CF3Ph (3-CIPh)CH2OCH2 CH3
G5-688 2-CF3Ph (4-CIPh)CH2OCH2 CH3
G5-689 2-CF3Ph (2-BrPh)CH2OCH2 CH3
G5-690 2-CF3Ph (3-BrPh)CH2OCH2 CH3
G5-691 2-CF3Ph (4-BrPh)CH2OCH2 CH3
G5-692 2-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G5-693 2-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G5-694 2-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G5-695 2-CF3Ph (2-CNPh)CH2OCH2 CH3
G5-696 2-CF3Ph (3-CNPh)CH2OCH2 CH3
G5-697 2-CF3Ph (4-CNPh)CH2OCH2 CH3
G5-698 2-CF3Ph (2-N02Ph)CH2OCH2 CH3
G5-699 2-CF3Ph (3-N02Ph)CH2OCH2 CH3
G5-700 2-CF3Ph (4-N02Ph)CH2OCH2 CH3
G5-701 2-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G5-702 2-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G5-703 2-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G5-704 2-CF3Ph CH3C(=0)OCH2 CH3
G5-705 2-CF3Ph CH3CH2C(=0)OCH2 CH3
G5-706 2-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G5-707 2-CF3Ph (CH3)3C(=0)OCH2 CH3
G5-708 2-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G5-709 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G5-710 2-CF3Ph CF3C(=0)OCH2 CH3
G5-711 2-CF3Ph CF3CF2C(=0)OCH2 CH3
G5-712 2-CF3Ph (c-hex)C(=0)OCH2 CH3
G5-713 2-CF3Ph PhC(=0)OCH2 CH3
G5-714 2-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G5-715 2-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G5-716 2-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G5-717 2-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G5-718 2-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G5-719 2-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G5-810 3-CF3Ph (3-CH3OPh)CH2OCH2 H
G5-811 3-CF3Ph (4-CH3OPh)CH2OCH2 H
G5-812 3-CF3Ph (2-FPh)CH2OCH2 H
G5-813 3-CF3Ph (3-FPh)CH2OCH2 H
G5-814 3-CF3Ph (4-FPh)CH2OCH2 H
G5-815 3-CF3Ph (2-CIPh)CH2OCH2 H
G5-816 3-CF3Ph (3-CIPh)CH2OCH2 H
G5-817 3-CF3Ph (4-CIPh)CH2OCH2 H
G5-818 3-CF3Ph (2-BrPh)CH2OCH2 H
G5-819 3-CF3Ph (3-BrPh)CH2OCH2 H
G5-820 3-CF3Ph (4-BrPh)CH2OCH2 H
G5-821 3-CF3Ph (2-CF3OPh)CH2OCH2 H
G5-822 3-CF3Ph (3-CF3OPh)CH2OCH2 H
G5-823 3-CF3Ph (4-CF3OPh)CH2OCH2 H
G5-824 3-CF3Ph (2-CNPh)CH2OCH2 H
G5-825 3-CF3Ph (3-CNPh)CH2OCH2 H
G5-826 3-CF3Ph (4-CNPh)CH2OCH2 H
G5-827 3-CF3Ph (2-N02Ph)CH2OCH2 H
G5-828 3-CF3Ph (3-N02Ph)CH2OCH2 H
G5-829 3-CF3Ph (4-N02Ph)CH2OCH2 H
G5-830 3-CF3Ph (2-CF3Ph)CH2OCH2 H
G5-831 3-CF3Ph (3-CF3Ph)CH2OCH2 H
G5-832 3-CF3Ph (4-CF3Ph)CH2OCH2 H
G5-833 3-CF3Ph CH3C(=0)OCH2 H
G5-834 3-CF3Ph CH3CH2C(=0)OCH2 H
G5-835 3-CF3Ph CH(CH3)2C(=0)OCH2 H
G5-836 3-CF3Ph (CH3)3C(=0)OCH2 H
G5-837 3-CF3Ph (CH3)3CCH2(=0)OCH2 H
G5-838 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G5-839 3-CF3Ph CF3C(=0)OCH2 H
G5-840 3-CF3Ph CF3CF2C(=0)OCH2 H
G5-841 3-CF3Ph (c-hex)C(=0)OCH2 H
G5-842 3-CF3Ph PhC(=0)OCH2 H
G5-843 3-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G5-844 3-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G5-845 3-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G5-846 3-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G5-847 3-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G5-848 3-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G5-849 3-CF3Ph (2-FPh)C(=0)OCH2 H
G5-850 3-CF3Ph (3-FPh)C(=0)OCH2 H
G5-851 3-CF3Ph (4-FPh)C(=0)OCH2 H
G5-852 3-CF3Ph (2-CIPh)C(=0)OCH2 H
G5-853 3-CF3Ph (3-CIPh)C(=0)OCH2 H
G5-854 3-CF3Ph (4-CIPh)C(=0)OCH2 H
G5-855 3-CF3Ph (2-BrPh)C(=0)OCH2 H
G5-856 3-CF3Ph (3-BrPh)C(=0)OCH2 H
G5-948 3-CF3Ph (3-BrPh)CH2OCH2 CH3
G5-949 3-CF3Ph (4-BrPh)CH2OCH2 CH3
G5-950 3-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G5-951 3-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G5-952 3-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G5-953 3-CF3Ph (2-CNPh)CH2OCH2 CH3
G5-954 3-CF3Ph (3-CNPh)CH2OCH2 CH3
G5-955 3-CF3Ph (4-CNPh)CH2OCH2 CH3
G5-956 3-CF3Ph (2-N02Ph)CH2OCH2 CH3
G5-957 3-CF3Ph (3-N02Ph)CH2OCH2 CH3
G5-958 3-CF3Ph (4-N02Ph)CH2OCH2 CH3
G5-959 3-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G5-960 3-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G5-961 3-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G5-962 3-CF3Ph CH3C(=0)OCH2 CH3
G5-963 3-CF3Ph CH3CH2C(=0)OCH2 CH3
G5-964 3-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G5-965 3-CF3Ph (CH3)3C(=0)OCH2 CH3
G5-966 3-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G5-967 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G5-968 3-CF3Ph CF3C(=0)OCH2 CH3
G5-969 3-CF3Ph CF3CF2C(=0)OCH2 CH3
G5-970 3-CF3Ph (c-hex)C(=0)OCH2 CH3
G5-971 3-CF3Ph PhC(=0)OCH2 CH3
G5-972 3-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G5-973 3-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G5-974 3-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G5-975 3-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G5-976 3-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G5-977 3-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G5-978 3-CF3Ph (2-FPh)C(=0)OCH2 CH3
G5-979 3-CF3Ph (3-FPh)C(=0)OCH2 CH3
G5-980 3-CF3Ph (4-FPh)C(=0)OCH2 CH3
G5-981 3-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G5-982 3-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G5-983 3-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G5-984 3-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G5-985 3-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G5-986 3-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G5-987 3-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G5-988 3-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G5-989 3-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G5-990 3-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G5-991 3-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G5-992 3-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G5-993 3-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G5-994 3-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G5-1038 4-CF3Ph (4-CH3Ph)OCH2 H
G5-1039 4-CF3Ph (2-CH3OPh)OCH2 H
G5-1040 4-CF3Ph (3-CH3OPh)OCH2 H
G5-1041 4-CF3Ph (4-CH3OPh)OCH2 H
G5-1042 4-CF3Ph (2-FPh)OCH2 H
G5-1043 4-CF3Ph (3-FPh)OCH2 H
G5-1044 4-CF3Ph (4-FPh)OCH2 H
G5-1045 4-CF3Ph (2-CIPh)OCH2 H
G5-1046 4-CF3Ph (3-CIPh)OCH2 H
G5-1047 4-CF3Ph (4-CIPh)OCH2 H
G5-1048 4-CF3Ph (2-BrPh)OCH2 H
G5-1049 4-CF3Ph (3-BrPh)OCH2 H
G5-1050 4-CF3Ph (4-BrPh)OCH2 H
G5-1051 4-CF3Ph (2-CF3OPh)OCH2 H
G5-1052 4-CF3Ph (3-CF3OPh)OCH2 H
G5-1053 4-CF3Ph (4-CF3OPh)OCH2 H
G5-1054 4-CF3Ph (2-CNPh)OCH2 H
G5-1055 4-CF3Ph (3-CNPh)OCH2 H
G5-1056 4-CF3Ph (4-CNPh)OCH2 H
G5-1057 4-CF3Ph (2-N02Ph)OCH2 H
G5-1058 4-CF3Ph (3-N02Ph)OCH2 H
G5-1059 4-CF3Ph (4-N02Ph)OCH2 H
G5-1060 4-CF3Ph (2-CF3Ph)OCH2 H
G5-1061 4-CF3Ph (3-CF3Ph)OCH2 H
G5-1062 4-CF3Ph (4-CF3Ph)OCH2 H
G5-1063 4-CF3Ph PhCH2OCH2 H
G5-1064 4-CF3Ph (2-CH3Ph)CH2OCH2 H
G5-1065 4-CF3Ph (3-CH3Ph)CH2OCH2 H
G5-1066 4-CF3Ph (4-CH3Ph)CH2OCH2 H
G5-1067 4-CF3Ph (2-CH3OPh)CH2OCH2 H
G5-1068 4-CF3Ph (3-CH3OPh)CH2OCH2 H
G5-1069 4-CF3Ph (4-CH3OPh)CH2OCH2 H
G5-1070 4-CF3Ph (2-FPh)CH2OCH2 H
G5-1071 4-CF3Ph (3-FPh)CH2OCH2 H
G5-1072 4-CF3Ph (4-FPh)CH2OCH2 H
G5-1073 4-CF3Ph (2-CIPh)CH2OCH2 H
G5-1074 4-CF3Ph (3-CIPh)CH2OCH2 H
G5-1075 4-CF3Ph (4-CIPh)CH2OCH2 H
G5-1076 4-CF3Ph (2-BrPh)CH2OCH2 H
G5-1077 4-CF3Ph (3-BrPh)CH2OCH2 H
G5-1078 4-CF3Ph (4-BrPh)CH2OCH2 H
G5-1079 4-CF3Ph (2-CF3OPh)CH2OCH2 H
G5-1080 4-CF3Ph (3-CF3OPh)CH2OCH2 H
G5-1081 4-CF3Ph (4-CF3OPh)CH2OCH2 H
G5-1082 4-CF3Ph (2-CNPh)CH2OCH2 H
G5-1083 4-CF3Ph (3-CNPh)CH2OCH2 H
G5-1084 4-CF3Ph (4-CNPh)CH2OCH2 H
G5-1085 4-CF3Ph (2-N02Ph)CH2OCH2 H
G5-1086 4-CF3Ph (3-N02Ph)CH2OCH2 H
G5-1087 4-CF3Ph (4-N02Ph)CH2OCH2 H
G5-1088 4-CF3Ph (2-CF3Ph)CH2OCH2 H
G5-1089 4-CF3Ph (3-CF3Ph)CH2OCH2 H
G5-1090 4-CF3Ph (4-CF3Ph)CH2OCH2 H
G5-1091 4-CF3Ph CH3C(=0)OCH2 H
G5-1092 4-CF3Ph CH3CH2C(=0)OCH2 H
G5-1093 4-CF3Ph CH(CH3)2C(=0)OCH2 H
G5-1094 4-CF3Ph (CH3)3C(=0)OCH2 H
G5-1095 4-CF3Ph (CH3)3CCH2(=0)OCH2 H
G5-1096 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G5-1097 4-CF3Ph CF3C(=0)OCH2 H
G5-1098 4-CF3Ph CF3CF2C(=0)OCH2 H
G5-1099 4-CF3Ph (c-hex)C(=0)OCH2 H
G5-1100 4-CF3Ph PhC(=0)OCH2 H
G5-1101 4-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G5-1102 4-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G5-1103 4-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G5-1104 4-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G5-1105 4-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G5-1106 4-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G5-1107 4-CF3Ph (2-FPh)C(=0)OCH2 H
G5-1108 4-CF3Ph (3-FPh)C(=0)OCH2 H
G5-1109 4-CF3Ph (4-FPh)C(=0)OCH2 H
G5-1110 4-CF3Ph (2-CIPh)C(=0)OCH2 H
G5-1111 4-CF3Ph (3-CIPh)C(=0)OCH2 H
G5-1112 4-CF3Ph (4-CIPh)C(=0)OCH2 H
G5-1113 4-CF3Ph (2-BrPh)C(=0)OCH2 H
G5-1114 4-CF3Ph (3-BrPh)C(=0)OCH2 H
G5-1115 4-CF3Ph (4-BrPh)C(=0)OCH2 H
G5-1116 4-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G5-1117 4-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G5-1118 4-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G5-1119 4-CF3Ph (2-CNPh)C(=0)OCH2 H
G5-1120 4-CF3Ph (3-CNPh)C(=0)OCH2 H
G5-1121 4-CF3Ph (4-CNPh)C(=0)OCH2 H
G5-1122 4-CF3Ph (2-N02Ph)C(=0)OCH2 H
G5-1123 4-CF3Ph (3-N02Ph)C(=0)OCH2 H
G5-1124 4-CF3Ph (4-N02Ph)C(=0)OCH2 H
G5-1125 4-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G5-1126 4-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G5-1127 4-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G5-1128 4-CF3Ph CH3 CH3
G5-1129 4-CF3Ph CH3CH2 CH3
G5-1130 4-CF3Ph CH3CH2CH2 CH3
G5-1131 4-CF3Ph (CH3)2CH CH3
G5-1132 4-CF3Ph CH3C(=0) CH3
G5-1176 4-CF3Ph (4-CIPh)OCH2 CH3
G5-1177 4-CF3Ph (2-BrPh)OCH2 CH3
G5-1178 4-CF3Ph (3-BrPh)OCH2 CH3
G5-1179 4-CF3Ph (4-BrPh)OCH2 CH3
G5-1180 4-CF3Ph (2-CF3OPh)OCH2 CH3
G5-1181 4-CF3Ph (3-CF3OPh)OCH2 CH3
G5-1182 4-CF3Ph (4-CF3OPh)OCH2 CH3
G5-1183 4-CF3Ph (2-CNPh)OCH2 CH3
G5-1184 4-CF3Ph (3-CNPh)OCH2 CH3
G5-1185 4-CF3Ph (4-CNPh)OCH2 CH3
G5-1186 4-CF3Ph (2-N02Ph)OCH2 CH3
G5-1187 4-CF3Ph (3-N02Ph)OCH2 CH3
G5-1188 4-CF3Ph (4-N02Ph)OCH2 CH3
G5-1189 4-CF3Ph (2-CF3Ph)OCH2 CH3
G5-1190 4-CF3Ph (3-CF3Ph)OCH2 CH3
G5-1191 4-CF3Ph (4-CF3Ph)OCH2 CH3
G5-1192 4-CF3Ph PhCH2OCH2 CH3
G5-1193 4-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G5-1194 4-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G5-1195 4-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G5-1196 4-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G5-1197 4-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G5-1198 4-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G5-1199 4-CF3Ph (2-FPh)CH2OCH2 CH3
G5-1200 4-CF3Ph (3-FPh)CH2OCH2 CH3
G5-1201 4-CF3Ph (4-FPh)CH2OCH2 CH3
G5-1202 4-CF3Ph (2-CIPh)CH2OCH2 CH3
G5-1203 4-CF3Ph (3-CIPh)CH2OCH2 CH3
G5-1204 4-CF3Ph (4-CIPh)CH2OCH2 CH3
G5-1205 4-CF3Ph (2-BrPh)CH2OCH2 CH3
G5-1206 4-CF3Ph (3-BrPh)CH2OCH2 CH3
G5-1207 4-CF3Ph (4-BrPh)CH2OCH2 CH3
G5-1208 4-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G5-1209 4-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G5-1210 4-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G5-1211 4-CF3Ph (2-CNPh)CH2OCH2 CH3
G5-1212 4-CF3Ph (3-CNPh)CH2OCH2 CH3
G5-1213 4-CF3Ph (4-CNPh)CH2OCH2 CH3
G5-1214 4-CF3Ph (2-N02Ph)CH2OCH2 CH3
G5-1215 4-CF3Ph (3-N02Ph)CH2OCH2 CH3
G5-1216 4-CF3Ph (4-N02Ph)CH2OCH2 CH3
G5-1217 4-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G5-1218 4-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G5-1219 4-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G5-1220 4-CF3Ph CH3C(=0)OCH2 CH3
G5-1221 4-CF3Ph CH3CH2C(=0)OCH2 CH3
G5-1222 4-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G5-1223 4-CF3Ph (CH3)3C(=0)OCH2 CH3
G5-1224 4-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G5-1225 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G5-1226 4-CF3Ph CF3C(=0)OCH2 CH3
G5-1227 4-CF3Ph CF3CF2C(=0)OCH2 CH3
G5-1228 4-CF3Ph (c-hex)C(=0)OCH2 CH3
G5-1229 4-CF3Ph PhC(=0)OCH2 CH3
G5-1230 4-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G5-1231 4-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G5-1232 4-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G5-1233 4-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G5-1234 4-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G5-1235 4-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G5-1236 4-CF3Ph (2-FPh)C(=0)OCH2 CH3
G5-1237 4-CF3Ph (3-FPh)C(=0)OCH2 CH3
G5-1238 4-CF3Ph (4-FPh)C(=0)OCH2 CH3
G5-1239 4-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G5-1240 4-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G5-1241 4-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G5-1242 4-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G5-1243 4-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G5-1244 4-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G5-1245 4-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G5-1246 4-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G5-1247 4-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G5-1248 4-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G5-1249 4-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G5-1250 4-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G5-1251 4-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G5-1252 4-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G5-1253 4-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G5-1254 4-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G5-1255 4-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G5-1256 4-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G5-1257 3,5-(CF3)2Ph CH3 H
G5-1258 3,5-(CF3)2Ph CH3CH2 H
G5-1259 3,5-(CF3)2Ph CH3CH2CH2 H
G5-1260 3,5-(CF3)2Ph (CH3)2CH H
G5-1261 3,5-(CF3)2Ph CH3C(=0) H
G5-1262 3,5-(CF3)2Ph CH3CH2C(=0) H
G5-1263 3,5-(CF3)2Ph (CH3)2CHC(=0) H
G5-1264 3,5-(CF3)2Ph (CH3)3CC(=0) H
G5-1265 3,5-(CF3)2Ph (CH3)3CCH2C(=0) H
G5-1266 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0) H
G5-1267 3,5-(CF3)2Ph (CH3)2CHCH2C(=0) H
G5-1268 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0) H
G5-1269 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0) H
G5-1270 3,5-(CF3)2Ph (c-hex)C(=Q) H
G5-1314 3,5-(CF3)2Ph (4-CNPh)OCH2 H
G5-1315 3,5-(CF3)2Ph (2-N02Ph)OCH2 H
G5-1316 3,5-(CF3)2Ph (3-N02Ph)OCH2 H
G5-1317 3,5-(CF3)2Ph (4-N02Ph)OCH2 H
G5-1318 3,5-(CF3)2Ph (2-CF3Ph)OCH2 H
G5-1319 3,5-(CF3)2Ph (3-CF3Ph)OCH2 H
G5-1320 3,5-(CF3)2Ph (4-CF3Ph)OCH2 H
G5-1321 3,5-(CF3)2Ph PhCH2OCH2 H
G5-1322 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2 H
G5-1323 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2 H
G5-1324 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2 H
G5-1325 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2 H
G5-1326 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 H
G5-1327 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 H
G5-1328 3,5-(CF3)2Ph (2-FPh)CH2OCH2 H
G5-1329 3,5-(CF3)2Ph (3-FPh)CH2OCH2 H
G5-1330 3,5-(CF3)2Ph (4-FPh)CH2OCH2 H
G5-1331 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 H
G5-1332 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 H
G5-1333 3,5-(CF3)2Ph (4-CIPh)CH2OCH2 H
G5-1334 3,5-(CF3)2Ph (2-BrPh)CH2OCH2 H
G5-1335 3,5-(CF3)2Ph (3-BrPh)CH2OCH2 H
G5-1336 3,5-(CF3)2Ph (4-BrPh)CH2OCH2 H
G5-1337 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2 H
G5-1338 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2 H
G5-1339 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2 H
G5-1340 3,5-(CF3)2Ph (2-CNPh)CH2OCH2 H
G5-1341 3,5-(CF3)2Ph (3-CNPh)CH2OCH2 H
G5-1342 3,5-(CF3)2Ph (4-CNPh)CH2OCH2 H
G5-1343 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2 H
G5-1344 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2 H
G5-1345 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2 H
G5-1346 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2 H
G5-1347 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2 H
G5-1348 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2 H
G5-1349 3,5-(CF3)2Ph CH3C(=0)OCH2 H
G5-1350 3,5-(CF3)2Ph CH3CH2C(=0)OCH2 H
G5-1351 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2 H
G5-1352 3,5-(CF3)2Ph (CH3)3C(=0)OCH2 H
G5-1353 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2 H
G5-1354 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2 H
G5-1355 3,5-(CF3)2Ph CF3C(=0)OCH2 H
G5-1356 3,5-(CF3)2Ph CF3CF2C(=0)OCH2 H
G5-1357 3,5-(CF3)2Ph (c-hex)C(=0)OCH2 H
G5-1358 3,5-(CF3)2Ph PhC(=0)OCH2 H
G5-1359 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2 H
G5-1360 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2 H
G5-1361 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2 H
G5-1362 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2 H
G5-1363 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2 H
G5-1364 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2 H
G5-1365 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2 H
G5-1366 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2 H
G5-1367 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2 H
G5-1368 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2 H
G5-1369 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2 H
G5-1370 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2 H
G5-1371 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2 H
G5-1372 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2 H
G5-1373 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2 H
G5-1374 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2 H
G5-1375 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2 H
G5-1376 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2 H
G5-1377 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2 H
G5-1378 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2 H
G5-1379 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2 H
G5-1380 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2 H
G5-1381 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2 H
G5-1382 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2 H
G5-1383 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2 H
G5-1384 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2 H
G5-1385 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2 H
G5-1386 3,5-(CF3)2Ph CH3 CH3
G5-1387 3,5-(CF3)2Ph CH3CH2 CH3
G5-1388 3,5-(CF3)2Ph CH3CH2CH2 CH3
G5-1389 3,5-(CF3)2Ph (CH3)2CH CH3
G5-1390 3,5-(CF3)2Ph CH3C(=0) CH3
G5-1391 3,5-(CF3)2Ph CH3CH2C(=0) CH3
G5-1392 3,5-(CF3)2Ph (CH3)2CHC(=0) CH3
G5-1393 3,5-(CF3)2Ph (CH3)3CC(=0) CH3
G5-1394 3,5-(CF3)2Ph (CH3)3CCH2C(=0) CH3
G5-1395 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0) CH3
G5-1396 3,5-(CF3)2Ph (CH3)2CHCH2C(=0) CH3
G5-1397 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0) CH3
G5-1398 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0) CH3
G5-1399 3,5-(CF3)2Ph (c-hex)C(=0) CH3
G5-1400 3,5-(CF3)2Ph (c-pen)C(=0) CH3
G5-1401 3,5-(CF3)2Ph (c-hep)C(=0) CH3
G5-1402 3,5-(CF3)2Ph (c-pro)C(=0) CH3
G5-1403 3,5-(CF3)2Ph CF3C(=0) CH3
G5-1404 3,5-(CF3)2Ph (CH3)2NC(=0) CH3
G5-1405 3,5-(CF3)2Ph (CH3CH2)2NC(=0) CH3
G5-1406 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0) CH3
G5-1407 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0) CH3
G5-1408 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0) CH3
G5-1409 3,5-(CF3)2Ph CH3ON(CH3)C(=0) CH3
G5-1410 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0) CH3
G5-141 1 3,5-(CF3)2Ph (CHCCH2)2NC(=0) CH3
G5-1412 3,5-(CF3)2Ph hO CH3
G5-1414 3,5-(CF3)2Ph CH3
G5-1415 3,5-(CF3)2Ph CH3OCH2 CH3
G5-1416 3,5-(CF3)2Ph CH3CH2OCH2 CH3
G5-1417 3,5-(CF3)2Ph (CH3)2CHOCH2 CH3
G5-1418 3,5-(CF3)2Ph (CH3)3COCH2 CH3
G5-1419 3,5-(CF3)2Ph (CH3)3CCH20CH2 CH3
G5-1420 3,5-(CF3)2Ph CH3CH2C(CH3)2OCH2 CH3
G5-1421 3,5-(CF3)2Ph (c-hex)OCH2 CH3
G5-1422 3,5-(CF3)2Ph PhOCH2 CH3
G5-1423 3,5-(CF3)2Ph (2-CH3Ph)OCH2 CH3
G5-1424 3,5-(CF3)2Ph (3-CH3Ph)OCH2 CH3
G5-1425 3,5-(CF3)2Ph (4-CH3Ph)OCH2 CH3
G5-1426 3,5-(CF3)2Ph (2-CH3OPh)OCH2 CH3
G5-1427 3,5-(CF3)2Ph (3-CH3OPh)OCH2 CH3
G5-1428 3,5-(CF3)2Ph (4-CH3OPh)OCH2 CH3
G5-1429 3,5-(CF3)2Ph (2-FPh)OCH2 CH3
G5-1430 3,5-(CF3)2Ph (3-FPh)OCH2 CH3
G5-1431 3,5-(CF3)2Ph (4-FPh)OCH2 CH3
G5-1432 3,5-(CF3)2Ph (2-CIPh)OCH2 CH3
G5-1433 3,5-(CF3)2Ph (3-CIPh)OCH2 CH3
G5-1434 3,5-(CF3)2Ph (4-CIPh)OCH2 CH3
G5-1435 3,5-(CF3)2Ph (2-BrPh)OCH2 CH3
G5-1436 3,5-(CF3)2Ph (3-BrPh)OCH2 CH3
G5-1437 3,5-(CF3)2Ph (4-BrPh)OCH2 CH3
G5-1438 3,5-(CF3)2Ph (2-CF3OPh)OCH2 CH3
G5-1439 3,5-(CF3)2Ph (3-CF3OPh)OCH2 CH3
G5-1440 3,5-(CF3)2Ph (4-CF3OPh)OCH2 CH3
G5-1441 3,5-(CF3)2Ph (2-CNPh)OCH2 CH3
G5-1442 3,5-(CF3)2Ph (3-CNPh)OCH2 CH3
G5-1443 3,5-(CF3)2Ph (4-CNPh)OCH2 CH3
G5-1444 3,5-(CF3)2Ph (2-N02Ph)OCH2 CH3
G5-1445 3,5-(CF3)2Ph (3-N02Ph)OCH2 CH3
G5-1446 3,5-(CF3)2Ph (4-N02Ph)OCH2 CH3
G5-1447 3,5-(CF3)2Ph (2-CF3Ph)OCH2 CH3
G5-1448 3,5-(CF3)2Ph (3-CF3Ph)OCH2 CH3
G5-1449 3,5-(CF3)2Ph (4-CF3Ph)OCH2 CH3
G5-1450 3,5-(CF3)2Ph PhCH2OCH2 CH3
G5-1451 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2 CH3
G5-1452 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2 CH3
G5-1453 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2 CH3
G5-1454 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2 CH3
G5-1455 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 CH3
G5-1456 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 CH3
G5-1457 3,5-(CF3)2Ph (2-FPh)CH2OCH2 CH3
G5-1458 3,5-(CF3)2Ph (3-FPh)CH2OCH2 CH3
G5-1459 3,5-(CF3)2Ph (4-FPh)CH2OCH2 CH3
G5-1460 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 CH3
G5-1461 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 CH3
G5-1462 3,5-(CF3)2Ph (4-CIPh)CH2OCH2 CH3
G5-1463 3,5-(CF3)2Ph (2-BrPh)CH2OCH2 CH3
G5-1464 3,5-(CF3)2Ph (3-BrPh)CH2OCH2 CH3
G5-1465 3,5-(CF3)2Ph (4-BrPh)CH2OCH2 CH3
G5-1466 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2 CH3
G5-1467 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2 CH3
G5-1468 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2 CH3
G5-1469 3,5-(CF3)2Ph (2-CNPh)CH2OCH2 CH3
G5-1470 3,5-(CF3)2Ph (3-CNPh)CH2OCH2 CH3
G5-1471 3,5-(CF3)2Ph (4-CNPh)CH2OCH2 CH3
G5-1472 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2 CH3
G5-1473 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2 CH3
G5-1474 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2 CH3
G5-1475 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2 CH3
G5-1476 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2 CH3
G5-1477 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2 CH3
G5-1478 3,5-(CF3)2Ph CH3C(=0)OCH2 CH3
G5-1479 3,5-(CF3)2Ph CH3CH2C(=0)OCH2 CH3
G5-1480 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2 CH3
G5-1481 3,5-(CF3)2Ph (CH3)3C(=0)OCH2 CH3
G5-1482 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2 CH3
G5-1483 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G5-1484 3,5-(CF3)2Ph CF3C(=0)OCH2 CH3
G5-1485 3,5-(CF3)2Ph CF3CF2C(=0)OCH2 CH3
G5-1486 3,5-(CF3)2Ph (c-hex)C(=0)OCH2 CH3
G5-1487 3,5-(CF3)2Ph PhC(=0)OCH2 CH3
G5-1488 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2 CH3
G5-1489 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2 CH3
G5-1490 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2 CH3
G5-1491 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2 CH3
G5-1492 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2 CH3
G5-1493 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2 CH3
G5-1494 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2 CH3
G5-1495 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2 CH3
G5-1496 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2 CH3
G5-1497 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2 CH3
G5-1498 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2 CH3
G5-1499 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2 CH3
G5-1500 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2 CH3
G5-1501 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2 CH3
G5-1502 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2 CH3
G5-1503 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2 CH3
G5-1504 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2 CH3
G5-1505 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2 CH3
G5-1506 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2 CH3
G5-1507 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2 CH3
G5-1508 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2 CH3
G5-1509 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2 CH3
G5-1510 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2 CH3
G5-1511 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2 CH3
G5-1512 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2 CH3
G5-1513 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2 CH3
G5-1514 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2 CH3
[0299] Table 6
G6-161 2-CF3-6-CN-Ph H CH3
G6-162 PhO H CH3
G6-163 2-CFsPhO H CH3
G6-164 3-CFsPhO H CH3
G6-165 4-CFsPhO H CH3
G6-166 2-CF3CF2PhO H CH3
G6-167 3-CF3CF2PhO H CH3
G6-168 4-CF3CF2PhO H CH3
G6-169 2-CFsOPhO H CH3
G6-170 3-CFsOPhO H CH3
G6-171 4-CFsOPhO H CH3
G6-172 2-CF3-3-F-PhO H CH3
G6-173 2-CF3-4-F-PhO H CH3
G6-174 2-CF3-5-F-PhO H CH3
G6-175 2-CF3-6-F-PhO H CH3
G6-176 2-CF3-3-CI-PhO H CH3
G6-177 2-CF3-4-CI-PhO H CH3
G6-178 2-CF3-5-CI-PhO H CH3
G6-179 2-CF3-6-CI-PhO H CH3
G6-180 2-CF3-3-CH3-PhO H CH3
G6-181 2-CF3-4-CH3-PhO H CH3
G6-182 2-CF3-5-CH3-PhO H CH3
G6-183 2-CF3-6-CH3-PhO H CH3
G6-184 2,3-(CF3)2PhO H CH3
G6-185 2,4-(CF3)2PhO H CH3
G6-186 2,6-(CF3)2PhO H CH3
G6-187 3,5-(CF3)2PhO H CH3
G6-188 PhCH20 H CH3
G6-189 2-CF3PhCH20 H CH3
G6-190 3-CF3PhCH20 H CH3
G6-191 4-CF3PhCH20 H CH3
G6-192 2-CF3CF2PhCH20 H CH3
G6-193 3-CF3CF2PhCH20 H CH3
G6-194 4-CF3CF2PhCH20 H CH3
G6-195 2-CF3OPhCH20 H CH3
G6-196 3-CF3OPhCH20 H CH3
G6-197 4-CF3OPhCH20 H CH3
G6-198 2-CF3-3-F-PhCH20 H CH3
G6-199 2-CF3-4-F-PhCH20 H CH3
G6-200 2-CF3-5-F-PhCH20 H CH3
G6-201 2-CF3-6-F-PhCH20 H CH3
G6-202 2-CF3-3-CI-PhCH20 H CH3
G6-203 2-CF3-4-CI-PhCH20 H CH3
G6-204 2-CF3-5-CI-PhCH20 H CH3
G6-205 2-CF3-6-CI-PhCH20 H CH3
G6-297 CF3 (3-FPh)CH2OCH2 H
G6-298 CF3 (4-FPh)CH2OCH2 H
G6-299 CF3 (2-CIPh)CH2OCH2 H
G6-300 CF3 (3-CIPh)CH2OCH2 H
G6-301 CF3 (4-CIPh)CH2OCH2 H
G6-302 CF3 (2-BrPh)CH2OCH2 H
G6-303 CF3 (3-BrPh)CH2OCH2 H
G6-304 CF3 (4-BrPh)CH2OCH2 H
G6-305 CF3 (2-CF3OPh)CH2OCH2 H
G6-306 CF3 (3-CF3OPh)CH2OCH2 H
G6-307 CF3 (4-CF3OPh)CH2OCH2 H
G6-308 CF3 (2-CNPh)CH2OCH2 H
G6-309 CF3 (3-CNPh)CH2OCH2 H
G6-310 CF3 (4-CNPh)CH2OCH2 H
G6-311 CF3 (2-N02Ph)CH2OCH2 H
G6-312 CF3 (3-N02Ph)CH2OCH2 H
G6-313 CF3 (4-N02Ph)CH2OCH2 H
G6-314 CF3 (2-CF3Ph)CH2OCH2 H
G6-315 CF3 (3-CF3Ph)CH2OCH2 H
G6-316 CF3 (4-CF3Ph)CH2OCH2 H
G6-317 CF3 CH3C(=0)OCH2 H
G6-318 CF3 CH3CH2C(=0)OCH2 H
G6-319 CF3 CH(CH3)2C(=0)OCH2 H
G6-320 CF3 (CH3)3C(=0)OCH2 H
G6-321 CF3 (CH3)3CCH2(=0)OCH2 H
G6-322 CF3 CH3CH2C(CH3)2C(=0)OCH2 H
G6-323 CF3 CF3C(=0)OCH2 H
G6-324 CF3 CF3CF2C(=0)OCH2 H
G6-325 CF3 (c-hex)C(=0)OCH2 H
G6-326 CF3 PhC(=0)OCH2 H
G6-327 CF3 (2-CH3Ph)C(=0)OCH2 H
G6-328 CF3 (3-CH3Ph)C(=0)OCH2 H
G6-329 CF3 (4-CH3Ph)C(=0)OCH2 H
G6-330 CF3 (2-CH3OPh)C(=0)OCH2 H
G6-331 CF3 (3-CH3OPh)C(=0)OCH2 H
G6-332 CF3 (4-CH3OPh)C(=0)OCH2 H
G6-333 CF3 (2-FPh)C(=0)OCH2 H
G6-334 CF3 (3-FPh)C(=0)OCH2 H
G6-335 CF3 (4-FPh)C(=0)OCH2 H
G6-336 CF3 (2-CIPh)C(=0)OCH2 H
G6-337 CF3 (3-CIPh)C(=0)OCH2 H
G6-338 CF3 (4-CIPh)C(=0)OCH2 H
G6-339 CF3 (2-BrPh)C(=0)OCH2 H
G6-340 CF3 (3-BrPh)C(=0)OCH2 H
G6-341 CF3 (4-BrPh)C(=0)OCH2 H
G6-342 CF3 (2-CF3OPh)C(=0)OCH2 H
G6-343 CF3 (3-CF3OPh)C(=0)OCH2 H
G6-387 CF3 (CH3)3CCH20CH2 CH3
G6-388 CF3 CH3CH2C(CH3)2OCH2 CH3
G6-389 CF3 (c-hex)OCH2 CH3
G6-390 CF3 PhOCH2 CH3
G6-391 CF3 (2-CH3Ph)OCH2 CH3
G6-392 CF3 (3-CH3Ph)OCH2 CH3
G6-393 CF3 (4-CH3Ph)OCH2 CH3
G6-394 CF3 (2-CH3OPh)OCH2 CH3
G6-395 CF3 (3-CH3OPh)OCH2 CH3
G6-396 CF3 (4-CH3OPh)OCH2 CH3
G6-397 CF3 (2-FPh)OCH2 CH3
G6-398 CF3 (3-FPh)OCH2 CH3
G6-399 CF3 (4-FPh)OCH2 CH3
G6-400 CF3 (2-CIPh)OCH2 CH3
G6-401 CF3 (3-CIPh)OCH2 CH3
G6-402 CF3 (4-CIPh)OCH2 CH3
G6-403 CF3 (2-BrPh)OCH2 CH3
G6-404 CF3 (3-BrPh)OCH2 CH3
G6-405 CF3 (4-BrPh)OCH2 CH3
G6-406 CF3 (2-CF3OPh)OCH2 CH3
G6-407 CF3 (3-CF3OPh)OCH2 CH3
G6-408 CF3 (4-CF3OPh)OCH2 CH3
G6-409 CF3 (2-CNPh)OCH2 CH3
G6-410 CF3 (3-CNPh)OCH2 CH3
G6-41 1 CF3 (4-CNPh)OCH2 CH3
G6-412 CF3 (2-N02Ph)OCH2 CH3
G6-413 CF3 (3-N02Ph)OCH2 CH3
G6-414 CF3 (4-N02Ph)OCH2 CH3
G6-415 CF3 (2-CF3Ph)OCH2 CH3
G6-416 CF3 (3-CF3Ph)OCH2 CH3
G6-417 CF3 (4-CF3Ph)OCH2 CH3
G6-418 CF3 PhCH2OCH2 CH3
G6-419 CF3 (2-CH3Ph)CH2OCH2 CH3
G6-420 CF3 (3-CH3Ph)CH2OCH2 CH3
G6-421 CF3 (4-CH3Ph)CH2OCH2 CH3
G6-422 CF3 (2-CH3OPh)CH2OCH2 CH3
G6-423 CF3 (3-CH3OPh)CH2OCH2 CH3
G6-424 CF3 (4-CH3OPh)CH2OCH2 CH3
G6-425 CF3 (2-FPh)CH2OCH2 CH3
G6-426 CF3 (3-FPh)CH2OCH2 CH3
G6-427 CF3 (4-FPh)CH2OCH2 CH3
G6-428 CF3 (2-CIPh)CH2OCH2 CH3
G6-429 CF3 (3-CIPh)CH2OCH2 CH3
G6-430 CF3 (4-CIPh)CH2OCH2 CH3
G6-431 CF3 (2-BrPh)CH2OCH2 CH3
G6-432 CF3 (3-BrPh)CH2OCH2 CH3
G6-433 CF3 (4-BrPh)CH2OCH2 CH3
G6-434 CF3 (2-CF3OPh)CH2OCH2 CH3
G6-435 CF3 (3-CF3OPh)CH2OCH2 CH3
G6-436 CF3 (4-CF3OPh)CH2OCH2 CH3
G6-437 CF3 (2-CNPh)CH2OCH2 CH3
G6-438 CF3 (3-CNPh)CH2OCH2 CH3
G6-439 CF3 (4-CNPh)CH2OCH2 CH3
G6-440 CF3 (2-N02Ph)CH2OCH2 CH3
G6-441 CF3 (3-N02Ph)CH2OCH2 CH3
G6-442 CF3 (4-N02Ph)CH2OCH2 CH3
G6-443 CF3 (2-CF3Ph)CH2OCH2 CH3
G6-444 CF3 (3-CF3Ph)CH2OCH2 CH3
G6-445 CF3 (4-CF3Ph)CH2OCH2 CH3
G6-446 CF3 CH3C(=0)OCH2 CH3
G6-447 CF3 CH3CH2C(=0)OCH2 CH3
G6-448 CF3 CH(CH3)2C(=0)OCH2 CH3
G6-449 CF3 (CH3)3C(=0)OCH2 CH3
G6-450 CF3 (CH3)3CCH2(=0)OCH2 CH3
G6-451 CF3 CH3CH2C(CH3)2C(=0)OCH2 CH3
G6-452 CF3 CF3C(=0)OCH2 CH3
G6-453 CF3 CF3CF2C(=0)OCH2 CH3
G6-454 CF3 (c-hex)C(=0)OCH2 CH3
G6-455 CF3 PhC(=0)OCH2 CH3
G6-456 CF3 (2-CH3Ph)C(=0)OCH2 CH3
G6-457 CF3 (3-CH3Ph)C(=0)OCH2 CH3
G6-458 CF3 (4-CH3Ph)C(=0)OCH2 CH3
G6-459 CF3 (2-CH3OPh)C(=0)OCH2 CH3
G6-460 CF3 (3-CH3OPh)C(=0)OCH2 CH3
G6-461 CF3 (4-CH3OPh)C(=0)OCH2 CH3
G6-462 CF3 (2-FPh)C(=0)OCH2 CH3
G6-463 CF3 (3-FPh)C(=0)OCH2 CH3
G6-464 CF3 (4-FPh)C(=0)OCH2 CH3
G6-465 CF3 (2-CIPh)C(=0)OCH2 CH3
G6-466 CF3 (3-CIPh)C(=0)OCH2 CH3
G6-467 CF3 (4-CIPh)C(=0)OCH2 CH3
G6-468 CF3 (2-BrPh)C(=0)OCH2 CH3
G6-469 CF3 (3-BrPh)C(=0)OCH2 CH3
G6-470 CF3 (4-BrPh)C(=0)OCH2 CH3
G6-471 CF3 (2-CF3OPh)C(=0)OCH2 CH3
G6-472 CF3 (3-CF3OPh)C(=0)OCH2 CH3
G6-473 CF3 (4-CF3OPh)C(=0)OCH2 CH3
G6-474 CF3 (2-CNPh)C(=0)OCH2 CH3
G6-475 CF3 (3-CNPh)C(=0)OCH2 CH3
G6-476 CF3 (4-CNPh)C(=0)OCH2 CH3
G6-477 CF3 (2-N02Ph)C(=0)OCH2 CH3
G6-478 CF3 (3-N02Ph)C(=0)OCH2 CH3
G6-479 CF3 (4-N02Ph)C(=0)OCH2 CH3
G6-480 CF3 (2-CF3Ph)C(=0)OCH2 CH3
G6-481 CF3 (3-CF3Ph)C(=0)OCH2 CH3
G6-525 2-CF3Ph (4-CH3OPh)OCH2 H
G6-526 2-CF3Ph (2-FPh)OCH2 H
G6-527 2-CF3Ph (3-FPh)OCH2 H
G6-528 2-CF3Ph (4-FPh)OCH2 H
G6-529 2-CF3Ph (2-CIPh)OCH2 H
G6-530 2-CF3Ph (3-CIPh)OCH2 H
G6-531 2-CF3Ph (4-CIPh)OCH2 H
G6-532 2-CF3Ph (2-BrPh)OCH2 H
G6-533 2-CF3Ph (3-BrPh)OCH2 H
G6-534 2-CF3Ph (4-BrPh)OCH2 H
G6-535 2-CF3Ph (2-CF3OPh)OCH2 H
G6-536 2-CF3Ph (3-CF3OPh)OCH2 H
G6-537 2-CF3Ph (4-CF3OPh)OCH2 H
G6-538 2-CF3Ph (2-CNPh)OCH2 H
G6-539 2-CF3Ph (3-CNPh)OCH2 H
G6-540 2-CF3Ph (4-CNPh)OCH2 H
G6-541 2-CF3Ph (2-N02Ph)OCH2 H
G6-542 2-CF3Ph (3-N02Ph)OCH2 H
G6-543 2-CF3Ph (4-N02Ph)OCH2 H
G6-544 2-CF3Ph (2-CF3Ph)OCH2 H
G6-545 2-CF3Ph (3-CF3Ph)OCH2 H
G6-546 2-CF3Ph (4-CF3Ph)OCH2 H
G6-547 2-CF3Ph PhCH2OCH2 H
G6-548 2-CF3Ph (2-CH3Ph)CH2OCH2 H
G6-549 2-CF3Ph (3-CH3Ph)CH2OCH2 H
G6-550 2-CF3Ph (4-CH3Ph)CH2OCH2 H
G6-551 2-CF3Ph (2-CH3OPh)CH2OCH2 H
G6-552 2-CF3Ph (3-CH3OPh)CH2OCH2 H
G6-553 2-CF3Ph (4-CH3OPh)CH2OCH2 H
G6-554 2-CF3Ph (2-FPh)CH2OCH2 H
G6-555 2-CF3Ph (3-FPh)CH2OCH2 H
G6-556 2-CF3Ph (4-FPh)CH2OCH2 H
G6-557 2-CF3Ph (2-CIPh)CH2OCH2 H
G6-558 2-CF3Ph (3-CIPh)CH2OCH2 H
G6-559 2-CF3Ph (4-CIPh)CH2OCH2 H
G6-560 2-CF3Ph (2-BrPh)CH2OCH2 H
G6-561 2-CF3Ph (3-BrPh)CH2OCH2 H
G6-562 2-CF3Ph (4-BrPh)CH2OCH2 H
G6-563 2-CF3Ph (2-CF3OPh)CH2OCH2 H
G6-564 2-CF3Ph (3-CF3OPh)CH2OCH2 H
G6-565 2-CF3Ph (4-CF3OPh)CH2OCH2 H
G6-566 2-CF3Ph (2-CNPh)CH2OCH2 H
G6-567 2-CF3Ph (3-CNPh)CH2OCH2 H
G6-568 2-CF3Ph (4-CNPh)CH2OCH2 H
G6-569 2-CF3Ph (2-N02Ph)CH2OCH2 H
G6-570 2-CF3Ph (3-N02Ph)CH2OCH2 H
G6-571 2-CF3Ph (4-N02Ph)CH2OCH2 H
G6-572 2-CF3Ph (2-CF3Ph)CH2OCH2 H
G6-573 2-CF3Ph (3-CF3Ph)CH2OCH2 H
G6-574 2-CF3Ph (4-CF3Ph)CH2OCH2 H
G6-575 2-CF3Ph CH3C(=0)OCH2 H
G6-576 2-CF3Ph CH3CH2C(=0)OCH2 H
G6-577 2-CF3Ph CH(CH3)2C(=0)OCH2 H
G6-578 2-CF3Ph (CH3)3C(=0)OCH2 H
G6-579 2-CF3Ph (CH3)3CCH2(=0)OCH2 H
G6-580 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G6-581 2-CF3Ph CF3C(=0)OCH2 H
G6-582 2-CF3Ph CF3CF2C(=0)OCH2 H
G6-583 2-CF3Ph (c-hex)C(=0)OCH2 H
G6-584 2-CF3Ph PhC(=0)OCH2 H
G6-585 2-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G6-586 2-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G6-587 2-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G6-588 2-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G6-589 2-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G6-590 2-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G6-591 2-CF3Ph (2-FPh)C(=0)OCH2 H
G6-592 2-CF3Ph (3-FPh)C(=0)OCH2 H
G6-593 2-CF3Ph (4-FPh)C(=0)OCH2 H
G6-594 2-CF3Ph (2-CIPh)C(=0)OCH2 H
G6-595 2-CF3Ph (3-CIPh)C(=0)OCH2 H
G6-596 2-CF3Ph (4-CIPh)C(=0)OCH2 H
G6-597 2-CF3Ph (2-BrPh)C(=0)OCH2 H
G6-598 2-CF3Ph (3-BrPh)C(=0)OCH2 H
G6-599 2-CF3Ph (4-BrPh)C(=0)OCH2 H
G6-600 2-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G6-601 2-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G6-602 2-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G6-603 2-CF3Ph (2-CNPh)C(=0)OCH2 H
G6-604 2-CF3Ph (3-CNPh)C(=0)OCH2 H
G6-605 2-CF3Ph (4-CNPh)C(=0)OCH2 H
G6-606 2-CF3Ph (2-N02Ph)C(=0)OCH2 H
G6-607 2-CF3Ph (3-N02Ph)C(=0)OCH2 H
G6-608 2-CF3Ph (4-N02Ph)C(=0)OCH2 H
G6-609 2-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G6-610 2-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G6-611 2-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G6-612 2-CF3Ph CH3 CH3
G6-613 2-CF3Ph CH3CH2 CH3
G6-614 2-CF3Ph CH3CH2CH2 CH3
G6-615 2-CF3Ph (CH3)2CH CH3
G6-616 2-CF3Ph CH3C(=0) CH3
G6-617 2-CF3Ph CH3CH2C(=0) CH3
G6-618 2-CF3Ph (CH3)2CHC(=0) CH3
G6-619 2-CF3Ph (CH3)3CC(=0) CH3
G6-620 2-CF3Ph (CH3)3CCH2C(=0) CH3
G6-621 2-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G6-622 2-CF3Ph (CH3)2CHCH2C(=0) CH3
G6-623 2-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G6-624 2-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G6-625 2-CF3Ph (c-hex)C(=0) CH3
G6-626 2-CF3Ph (c-pen)C(=0) CH3
G6-627 2-CF3Ph (c-hep)C(=0) CH3
G6-628 2-CF3Ph (c-pro)C(=0) CH3
G6-629 2-CF3Ph CF3C(=0) CH3
G6-630 2-CF3Ph (CH3)2NC(=0) CH3
G6-631 2-CF3Ph (CH3CH2)2NC(=0) CH3
G6-632 2-CF3Ph (CH3CH2CH2)2NC(=0) CH3
G6-633 2-CF3Ph CH3CH2N(CH3)C(=0) CH3
G6-634 2-CF3Ph [(CH3)2CHCH2]2NC(=0) CH3
G6-635 2-CF3Ph CH3ON(CH3)C(=0) CH3
G6-636 2-CF3Ph (CH2=CHCH2)2N C(=0) CH3
G6-637 2-CF3Ph (CHCCH2)2NC(=0) CH3
G6-638 2-CF3Ph CH3
G6-639 2-CF3Ph CH3
G6-640 2-CF3Ph CH3
G6-641 2-CF3Ph CH3OCH2 CH3
G6-642 2-CF3Ph CH3CH2OCH2 CH3
G6-643 2-CF3Ph (CH3)2CHOCH2 CH3
G6-644 2-CF3Ph (CH3)3COCH2 CH3
G6-645 2-CF3Ph (CH3)3CCH2OCH2 CH3
G6-646 2-CF3Ph CH3CH2C(CH3)2OCH2 CH3
G6-647 2-CF3Ph (c-hex)OCH2 CH3
G6-648 2-CF3Ph PhOCH2 CH3
G6-649 2-CF3Ph (2-CH3Ph)OCH2 CH3
G6-650 2-CF3Ph (3-CH3Ph)OCH2 CH3
G6-651 2-CF3Ph (4-CH3Ph)OCH2 CH3
G6-652 2-CF3Ph (2-CH3OPh)OCH2 CH3
G6-653 2-CF3Ph (3-CH3OPh)OCH2 CH3
G6-654 2-CF3Ph (4-CH3OPh)OCH2 CH3
G6-655 2-CF3Ph (2-FPh)OCH2 CH3
G6-656 2-CF3Ph (3-FPh)OCH2 CH3
G6-657 2-CF3Ph (4-FPh)OCH2 CH3
G6-658 2-CF3Ph (2-CIPh)OCH2 CH3
G6-659 2-CF3Ph (3-CIPh)OCH2 CH3
G6-660 2-CF3Ph (4-CIPh)OCH2 CH3
G6-661 2-CF3Ph (2-BrPh)OCH2 CH3
G6-662 2-CF3Ph (3-BrPh)OCH2 CH3
G6-663 2-CF3Ph (4-BrPh)OCH2 CH3
G6-664 2-CF3Ph (2-CF3OPh)OCH2 CH3
G6-665 2-CF3Ph (3-CF3OPh)OCH2 CH3
G6-666 2-CF3Ph (4-CF3OPh)OCH2 CH3
G6-667 2-CF3Ph (2-CNPh)OCH2 CH3
G6-668 2-CF3Ph (3-CNPh)OCH2 CH3
G6-669 2-CF3Ph (4-CNPh)OCH2 CH3
G6-670 2-CF3Ph (2-N02Ph)OCH2 CH3
G6-671 2-CF3Ph (3-N02Ph)OCH2 CH3
G6-672 2-CF3Ph (4-N02Ph)OCH2 CH3
G6-673 2-CF3Ph (2-CF3Ph)OCH2 CH3
G6-674 2-CF3Ph (3-CF3Ph)OCH2 CH3
G6-675 2-CF3Ph (4-CF3Ph)OCH2 CH3
G6-676 2-CF3Ph PhCH2OCH2 CH3
G6-677 2-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G6-678 2-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G6-679 2-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G6-680 2-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G6-681 2-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G6-682 2-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G6-683 2-CF3Ph (2-FPh)CH2OCH2 CH3
G6-684 2-CF3Ph (3-FPh)CH2OCH2 CH3
G6-685 2-CF3Ph (4-FPh)CH2OCH2 CH3
G6-686 2-CF3Ph (2-CIPh)CH2OCH2 CH3
G6-687 2-CF3Ph (3-CIPh)CH2OCH2 CH3
G6-688 2-CF3Ph (4-CIPh)CH2OCH2 CH3
G6-689 2-CF3Ph (2-BrPh)CH2OCH2 CH3
G6-690 2-CF3Ph (3-BrPh)CH2OCH2 CH3
G6-691 2-CF3Ph (4-BrPh)CH2OCH2 CH3
G6-692 2-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G6-693 2-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G6-694 2-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G6-695 2-CF3Ph (2-CNPh)CH2OCH2 CH3
G6-696 2-CF3Ph (3-CNPh)CH2OCH2 CH3
G6-697 2-CF3Ph (4-CNPh)CH2OCH2 CH3
G6-698 2-CF3Ph (2-N02Ph)CH2OCH2 CH3
G6-699 2-CF3Ph (3-N02Ph)CH2OCH2 CH3
G6-700 2-CF3Ph (4-N02Ph)CH2OCH2 CH3
G6-701 2-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G6-702 2-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G6-703 2-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G6-704 2-CF3Ph CH3C(=0)OCH2 CH3
G6-705 2-CF3Ph CH3CH2C(=0)OCH2 CH3
G6-706 2-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G6-707 2-CF3Ph (CH3)3C(=0)OCH2 CH3
G6-708 2-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G6-709 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G6-710 2-CF3Ph CF3C(=0)OCH2 CH3
G6-711 2-CF3Ph CF3CF2C(=0)OCH2 CH3
G6-712 2-CF3Ph (c-hex)C(=0)OCH2 CH3
G6-713 2-CF3Ph PhC(=0)OCH2 CH3
G6-714 2-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G6-715 2-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G6-716 2-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G6-717 2-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G6-718 2-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G6-719 2-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G6-720 2-CF3Ph (2-FPh)C(=0)OCH2 CH3
G6-721 2-CF3Ph (3-FPh)C(=0)OCH2 CH3
G6-722 2-CF3Ph (4-FPh)C(=0)OCH2 CH3
G6-723 2-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G6-724 2-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G6-725 2-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G6-726 2-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G6-727 2-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G6-728 2-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G6-729 2-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G6-730 2-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G6-731 2-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G6-732 2-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G6-733 2-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G6-734 2-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G6-735 2-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G6-736 2-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G6-737 2-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G6-738 2-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G6-739 2-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G6-740 2-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G6-741 3-CF3Ph CH3 H
G6-742 3-CF3Ph CH3CH2 H
G6-743 3-CF3Ph CH3CH2CH2 H
G6-744 3-CF3Ph (CH3)2CH H
G6-745 3-CF3Ph CH3C(=0) H
G6-746 3-CF3Ph CH3CH2C(=0) H
G6-747 3-CF3Ph (CH3)2CHC(=0) H
G6-748 3-CF3Ph (CH3)3CC(=0) H
G6-749 3-CF3Ph (CH3)3CCH2C(=0) H
G6-750 3-CF3Ph CH3CH2CH(CH3)C(=0) H
G6-751 3-CF3Ph (CH3)2CHCH2C(=0) H
G6-752 3-CF3Ph (CH3)3CCH2CH2C(=0) H
G6-753 3-CF3Ph CH3CH2C(CH3)2C(=0) H
G6-754 3-CF3Ph (c-hex)C(=0) H
G6-755 3-CF3Ph (c-pen)C(=0) H
G6-756 3-CF3Ph (c-hep)C(=0) H
G6-757 3-CF3Ph (c-pro)C(=0) H
G6-758 3-CF3Ph CF3C(=0) H
G6-759 3-CF3Ph (CH3)2NC(=0) H
G6-760 3-CF3Ph (CH3CH2)2NC(=0) H
G6-761 3-CF3Ph (CH3CH2CH2)2NC(=0) H
G6-762 3-CF3Ph CH3CH2N(CH3)C(=0) H
G6-763 3-CF3Ph [(CH3)2CHCH2]2NC(=0) H
G6-764 3-CF3Ph CH3ON(CH3)C(=0) H
G6-765 3-CF3Ph (CH2=CHCH2)2N C(=0) H
G6-766 3-CF3Ph (CHCCH2)2NC(=0) H
G6-767 3-CF3Ph H
G6-768 3-CF3Ph H
G6-769 3-CF3Ph H
G6-770 3-CF3Ph CH3OCH2 H
G6-771 3-CF3Ph CH3CH2OCH2 H
G6-772 3-CF3Ph (CH3)2CHOCH2 H
G6-773 3-CF3Ph (CH3)3COCH2 H
G6-774 3-CF3Ph (CH3)3CCH2OCH2 H
G6-775 3-CF3Ph CH3CH2C(CH3)2OCH2 H
G6-776 3-CF3Ph (c-hex)OCH2 H
G6-777 3-CF3Ph PhOCH2 H
G6-778 3-CF3Ph (2-CH3Ph)OCH2 H
G6-779 3-CF3Ph (3-CH3Ph)OCH2 H
G6-780 3-CF3Ph (4-CH3Ph)OCH2 H
G6-781 3-CF3Ph (2-CH3OPh)OCH2 H
G6-782 3-CF3Ph (3-CH3OPh)OCH2 H
G6-783 3-CF3Ph (4-CH3OPh)OCH2 H
G6-784 3-CF3Ph (2-FPh)OCH2 H
G6-785 3-CF3Ph (3-FPh)OCH2 H
G6-786 3-CF3Ph (4-FPh)OCH2 H
G6-787 3-CF3Ph (2-CIPh)OCH2 H
G6-788 3-CF3Ph (3-CIPh)OCH2 H
G6-789 3-CF3Ph (4-CIPh)OCH2 H
G6-790 3-CF3Ph (2-BrPh)OCH2 H
G6-791 3-CF3Ph (3-BrPh)OCH2 H
G6-792 3-CF3Ph (4-BrPh)OCH2 H
G6-793 3-CF3Ph (2-CF3OPh)OCH2 H
G6-794 3-CF3Ph (3-CF3OPh)OCH2 H
G6-795 3-CF3Ph (4-CF3OPh)OCH2 H
G6-796 3-CF3Ph (2-CNPh)OCH2 H
G6-797 3-CF3Ph (3-CNPh)OCH2 H
G6-798 3-CF3Ph (4-CNPh)OCH2 H
G6-799 3-CF3Ph (2-N02Ph)OCH2 H
G6-800 3-CF3Ph (3-N02Ph)OCH2 H
G6-801 3-CF3Ph (4-N02Ph)OCH2 H
G6-802 3-CF3Ph (2-CF3Ph)OCH2 H
G6-803 3-CF3Ph (3-CF3Ph)OCH2 H
G6-804 3-CF3Ph (4-CF3Ph)OCH2 H
G6-805 3-CF3Ph PhCH2OCH2 H
G6-806 3-CF3Ph (2-CH3Ph)CH2OCH2 H
G6-807 3-CF3Ph (3-CH3Ph)CH2OCH2 H
G6-808 3-CF3Ph (4-CH3Ph)CH2OCH2 H
G6-809 3-CF3Ph (2-CH3OPh)CH2OCH2 H
G6-810 3-CF3Ph (3-CH3OPh)CH2OCH2 H
G6-811 3-CF3Ph (4-CH3OPh)CH2OCH2 H
G6-812 3-CF3Ph (2-FPh)CH2OCH2 H
G6-813 3-CF3Ph (3-FPh)CH2OCH2 H
G6-814 3-CF3Ph (4-FPh)CH2OCH2 H
G6-815 3-CF3Ph (2-CIPh)CH2OCH2 H
G6-816 3-CF3Ph (3-CIPh)CH2OCH2 H
G6-817 3-CF3Ph (4-CIPh)CH2OCH2 H
G6-818 3-CF3Ph (2-BrPh)CH2OCH2 H
G6-819 3-CF3Ph (3-BrPh)CH2OCH2 H
G6-820 3-CF3Ph (4-BrPh)CH2OCH2 H
G6-821 3-CF3Ph (2-CF3OPh)CH2OCH2 H
G6-822 3-CF3Ph (3-CF3OPh)CH2OCH2 H
G6-823 3-CF3Ph (4-CF3OPh)CH2OCH2 H
G6-824 3-CF3Ph (2-CNPh)CH2OCH2 H
G6-825 3-CF3Ph (3-CNPh)CH2OCH2 H
G6-826 3-CF3Ph (4-CNPh)CH2OCH2 H
G6-827 3-CF3Ph (2-N02Ph)CH2OCH2 H
G6-828 3-CF3Ph (3-N02Ph)CH2OCH2 H
G6-829 3-CF3Ph (4-N02Ph)CH2OCH2 H
G6-830 3-CF3Ph (2-CF3Ph)CH2OCH2 H
G6-831 3-CF3Ph (3-CF3Ph)CH2OCH2 H
G6-832 3-CF3Ph (4-CF3Ph)CH2OCH2 H
G6-833 3-CF3Ph CH3C(=0)OCH2 H
G6-834 3-CF3Ph CH3CH2C(=0)OCH2 H
G6-835 3-CF3Ph CH(CH3)2C(=0)OCH2 H
G6-836 3-CF3Ph (CH3)3C(=0)OCH2 H
G6-837 3-CF3Ph (CH3)3CCH2(=0)OCH2 H
G6-838 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G6-839 3-CF3Ph CF3C(=0)OCH2 H
G6-840 3-CF3Ph CF3CF2C(=0)OCH2 H
G6-841 3-CF3Ph (c-hex)C(=0)OCH2 H
G6-842 3-CF3Ph PhC(=0)OCH2 H
G6-843 3-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G6-844 3-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G6-845 3-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G6-846 3-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G6-847 3-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G6-848 3-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G6-849 3-CF3Ph (2-FPh)C(=0)OCH2 H
G6-850 3-CF3Ph (3-FPh)C(=0)OCH2 H
G6-851 3-CF3Ph (4-FPh)C(=0)OCH2 H
G6-852 3-CF3Ph (2-CIPh)C(=0)OCH2 H
G6-853 3-CF3Ph (3-CIPh)C(=0)OCH2 H
G6-854 3-CF3Ph (4-CIPh)C(=0)OCH2 H
G6-855 3-CF3Ph (2-BrPh)C(=0)OCH2 H
G6-856 3-CF3Ph (3-BrPh)C(=0)OCH2 H
G6-857 3-CF3Ph (4-BrPh)C(=0)OCH2 H
G6-858 3-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G6-859 3-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G6-860 3-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G6-861 3-CF3Ph (2-CNPh)C(=0)OCH2 H
G6-862 3-CF3Ph (3-CNPh)C(=0)OCH2 H
G6-863 3-CF3Ph (4-CNPh)C(=0)OCH2 H
G6-864 3-CF3Ph (2-N02Ph)C(=0)OCH2 H
G6-865 3-CF3Ph (3-N02Ph)C(=0)OCH2 H
G6-866 3-CF3Ph (4-N02Ph)C(=0)OCH2 H
G6-867 3-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G6-868 3-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G6-869 3-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G6-870 3-CF3Ph CH3 CH3
G6-871 3-CF3Ph CH3CH2 CH3
G6-872 3-CF3Ph CH3CH2CH2 CH3
G6-873 3-CF3Ph (CH3)2CH CH3
G6-874 3-CF3Ph CH3C(=0) CH3
G6-875 3-CF3Ph CH3CH2C(=0) CH3
G6-876 3-CF3Ph (CH3)2CHC(=0) CH3
G6-877 3-CF3Ph (CH3)3CC(=0) CH3
G6-878 3-CF3Ph (CH3)3CCH2C(=0) CH3
G6-879 3-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G6-880 3-CF3Ph (CH3)2CHCH2C(=0) CH3
G6-881 3-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G6-882 3-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G6-883 3-CF3Ph (c-hex)C(=0) CH3
G6-884 3-CF3Ph (c-pen)C(=0) CH3
G6-885 3-CF3Ph (c-hep)C(=0) CH3
G6-886 3-CF3Ph (c-pro)C(=0) CH3
G6-887 3-CF3Ph CF3C(=0) CH3
G6-888 3-CF3Ph (CH3)2NC(=0) CH3
G6-889 3-CF3Ph (CH3CH2)2NC(=0) CH3
G6-890 3-CF3Ph (CH3CH2CH2)2NC(=0) CH3
G6-891 3-CF3Ph CH3CH2N(CH3)C(=0) CH3
G6-892 3-CF3Ph [(CH3)2CHCH2]2NC(=0) CH3
G6-893 3-CF3Ph CH3ON(CH3)C(=0) CH3
G6-894 3-CF3Ph (CH2=CHCH2)2N C(=0) CH3
G6-895 3-CF3Ph (CHCCH2)2NC(=0) CH3
G6-896 3-CF3Ph CH3
G6-897 3-CF3Ph CH3
G6-898 3-CF3Ph CH3
G6-899 3-CF3Ph CH3OCH2 CH3
G6-900 3-CF3Ph CH3CH20CH2 CH3
G6-901 3-CF3Ph (CH3)2CHOCH2 CH3
G6-902 3-CF3Ph (CH3)3COCH2 CH3
G6-903 3-CF3Ph (CH3)3CCH20CH2 CH3
G6-904 3-CF3Ph CH3CH2C(CH3)2OCH2 CH3
G6-905 3-CF3Ph (c-hex)OCH2 CH3
G6-906 3-CF3Ph PhOCH2 CH3
G6-907 3-CF3Ph (2-CH3Ph)OCH2 CH3
G6-908 3-CF3Ph (3-CH3Ph)OCH2 CH3
G6-909 3-CF3Ph (4-CH3Ph)OCH2 CH3
G6-910 3-CF3Ph (2-CH3OPh)OCH2 CH3
G6-911 3-CF3Ph (3-CH3OPh)OCH2 CH3
G6-912 3-CF3Ph (4-CH3OPh)OCH2 CH3
G6-913 3-CF3Ph (2-FPh)OCH2 CH3
G6-914 3-CF3Ph (3-FPh)OCH2 CH3
G6-915 3-CF3Ph (4-FPh)OCH2 CH3
G6-916 3-CF3Ph (2-CIPh)OCH2 CH3
G6-917 3-CF3Ph (3-CIPh)OCH2 CH3
G6-918 3-CF3Ph (4-CIPh)OCH2 CH3
G6-919 3-CF3Ph (2-BrPh)OCH2 CH3
G6-920 3-CF3Ph (3-BrPh)OCH2 CH3
G6-921 3-CF3Ph (4-BrPh)OCH2 CH3
G6-922 3-CF3Ph (2-CF3OPh)OCH2 CH3
G6-923 3-CF3Ph (3-CF3OPh)OCH2 CH3
G6-924 3-CF3Ph (4-CF3OPh)OCH2 CH3
G6-925 3-CF3Ph (2-CNPh)OCH2 CH3
G6-926 3-CF3Ph (3-CNPh)OCH2 CH3
G6-927 3-CF3Ph (4-CNPh)OCH2 CH3
G6-928 3-CF3Ph (2-N02Ph)OCH2 CH3
G6-929 3-CF3Ph (3-N02Ph)OCH2 CH3
G6-930 3-CF3Ph (4-N02Ph)OCH2 CH3
G6-931 3-CF3Ph (2-CF3Ph)OCH2 CH3
G6-932 3-CF3Ph (3-CF3Ph)OCH2 CH3
G6-933 3-CF3Ph (4-CF3Ph)OCH2 CH3
G6-934 3-CF3Ph PhCH2OCH2 CH3
G6-935 3-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G6-936 3-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G6-937 3-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G6-938 3-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G6-939 3-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G6-940 3-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G6-941 3-CF3Ph (2-FPh)CH2OCH2 CH3
G6-942 3-CF3Ph (3-FPh)CH2OCH2 CH3
G6-943 3-CF3Ph (4-FPh)CH2OCH2 CH3
G6-944 3-CF3Ph (2-CIPh)CH2OCH2 CH3
G6-945 3-CF3Ph (3-CIPh)CH2OCH2 CH3
G6-946 3-CF3Ph (4-CIPh)CH2OCH2 CH3
G6-947 3-CF3Ph (2-BrPh)CH2OCH2 CH3
G6-948 3-CF3Ph (3-BrPh)CH2OCH2 CH3
G6-949 3-CF3Ph (4-BrPh)CH2OCH2 CH3
G6-950 3-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G6-951 3-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G6-952 3-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G6-953 3-CF3Ph (2-CNPh)CH2OCH2 CH3
G6-954 3-CF3Ph (3-CNPh)CH2OCH2 CH3
G6-955 3-CF3Ph (4-CNPh)CH2OCH2 CH3
G6-956 3-CF3Ph (2-N02Ph)CH2OCH2 CH3
G6-957 3-CF3Ph (3-N02Ph)CH2OCH2 CH3
G6-958 3-CF3Ph (4-N02Ph)CH2OCH2 CH3
G6-959 3-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G6-960 3-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G6-961 3-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G6-962 3-CF3Ph CH3C(=0)OCH2 CH3
G6-963 3-CF3Ph CH3CH2C(=0)OCH2 CH3
G6-964 3-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G6-965 3-CF3Ph (CH3)3C(=0)OCH2 CH3
G6-966 3-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G6-967 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G6-968 3-CF3Ph CF3C(=0)OCH2 CH3
G6-969 3-CF3Ph CF3CF2C(=0)OCH2 CH3
G6-970 3-CF3Ph (c-hex)C(=0)OCH2 CH3
G6-971 3-CF3Ph PhC(=0)OCH2 CH3
G6-972 3-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G6-973 3-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G6-974 3-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G6-975 3-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G6-976 3-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G6-977 3-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G6-978 3-CF3Ph (2-FPh)C(=0)OCH2 CH3
G6-979 3-CF3Ph (3-FPh)C(=0)OCH2 CH3
G6-980 3-CF3Ph (4-FPh)C(=0)OCH2 CH3
G6-981 3-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G6-982 3-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G6-983 3-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G6-984 3-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G6-985 3-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G6-986 3-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G6-987 3-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G6-988 3-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G6-989 3-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G6-990 3-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G6-991 3-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G6-992 3-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G6-993 3-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G6-994 3-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G6-995 3-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G6-996 3-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G6-997 3-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G6-998 3-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G6-999 4-CF3Ph CH3 H
G6-1000 4-CF3Ph CH3CH2 H
G6-1001 4-CF3Ph CH3CH2CH2 H
G6-1002 4-CF3Ph (CH3)2CH H
G6-1003 4-CF3Ph CH3C(=0) H
G6-1004 4-CF3Ph CH3CH2C(=0) H
G6-1005 4-CF3Ph (CH3)2CHC(=0) H
G6-1006 4-CF3Ph (CH3)3CC(=0) H
G6-1007 4-CF3Ph (CH3)3CCH2C(=0) H
G6-1008 4-CF3Ph CH3CH2CH(CH3)C(=0) H
G6-1009 4-CF3Ph (CH3)2CHCH2C(=0) H
G6-1010 4-CF3Ph (CH3)3CCH2CH2C(=0) H
G6-1011 4-CF3Ph CH3CH2C(CH3)2C(=0) H
G6-1012 4-CF3Ph (c-hex)C(=0) H
G6-1013 4-CF3Ph (c-pen)C(=0) H
G6-1014 4-CF3Ph (c-hep)C(=0) H
G6-1015 4-CF3Ph (c-pro)C(=0) H
G6-1016 4-CF3Ph CF3C(=0) H
G6-1017 4-CF3Ph (CH3)2NC(=0) H
G6-1018 4-CF3Ph (CH3CH2)2NC(=0) H
G6-1019 4-CF3Ph (CH3CH2CH2)2NC(=0) H
G6-1020 4-CF3Ph CH3CH2N(CH3)C(=0) H
G6-1021 4-CF3Ph [(CH3)2CHCH2]2NC(=0) H
G6-1022 4-CF3Ph CH3ON(CH3)C(=0) H
G6-1023 4-CF3Ph (CH2=CHCH2)2N C(=0) H
G6-1024 4-CF3Ph (CHCCH2)2NC(=0) H
G6-1025 4-CF3Ph H
G6-1026 4-CF3Ph H
G6-1027 4-CF3Ph H
G6-1028 4-CF3Ph CH3OCH2 H
G6-1029 4-CF3Ph CH3CH20CH2 H
G6-1030 4-CF3Ph (CH3)2CHOCH2 H
G6-1031 4-CF3Ph (CH3)3COCH2 H
G6-1032 4-CF3Ph (CH3)3CCH20CH2 H
G6-1033 4-CF3Ph CH3CH2C(CH3)2OCH2 H
G6-1034 4-CF3Ph (c-hex)OCH2 H
G6-1035 4-CF3Ph PhOCH2 H
G6-1036 4-CF3Ph (2-CH3Ph)OCH2 H
G6-1037 4-CF3Ph (3-CH3Ph)OCH2 H
G6-1038 4-CF3Ph (4-CH3Ph)OCH2 H
G6-1039 4-CF3Ph (2-CH3OPh)OCH2 H
G6-1040 4-CF3Ph (3-CH3OPh)OCH2 H
G6-1041 4-CF3Ph (4-CH3OPh)OCH2 H
G6-1042 4-CF3Ph (2-FPh)OCH2 H
G6-1043 4-CF3Ph (3-FPh)OCH2 H
G6-1044 4-CF3Ph (4-FPh)OCH2 H
G6-1045 4-CF3Ph (2-CIPh)OCH2 H
G6-1046 4-CF3Ph (3-CIPh)OCH2 H
G6-1047 4-CF3Ph (4-CIPh)OCH2 H
G6-1048 4-CF3Ph (2-BrPh)OCH2 H
G6-1049 4-CF3Ph (3-BrPh)OCH2 H
G6-1050 4-CF3Ph (4-BrPh)OCH2 H
G6-1051 4-CF3Ph (2-CF3OPh)OCH2 H
G6-1052 4-CF3Ph (3-CF3OPh)OCH2 H
G6-1053 4-CF3Ph (4-CF3OPh)OCH2 H
G6-1054 4-CF3Ph (2-CNPh)OCH2 H
G6-1055 4-CF3Ph (3-CNPh)OCH2 H
G6-1056 4-CF3Ph (4-CNPh)OCH2 H
G6-1057 4-CF3Ph (2-N02Ph)OCH2 H
G6-1058 4-CF3Ph (3-N02Ph)OCH2 H
G6-1059 4-CF3Ph (4-N02Ph)OCH2 H
G6-1060 4-CF3Ph (2-CF3Ph)OCH2 H
G6-1061 4-CF3Ph (3-CF3Ph)OCH2 H
G6-1062 4-CF3Ph (4-CF3Ph)OCH2 H
G6-1063 4-CF3Ph PhCH2OCH2 H
G6-1064 4-CF3Ph (2-CH3Ph)CH2OCH2 H
G6-1065 4-CF3Ph (3-CH3Ph)CH2OCH2 H
G6-1066 4-CF3Ph (4-CH3Ph)CH2OCH2 H
G6-1067 4-CF3Ph (2-CH3OPh)CH2OCH2 H
G6-1068 4-CF3Ph (3-CH3OPh)CH2OCH2 H
G6-1069 4-CF3Ph (4-CH3OPh)CH2OCH2 H
G6-1070 4-CF3Ph (2-FPh)CH2OCH2 H
G6-1071 4-CF3Ph (3-FPh)CH2OCH2 H
G6-1072 4-CF3Ph (4-FPh)CH2OCH2 H
G6-1073 4-CF3Ph (2-CIPh)CH2OCH2 H
G6-1074 4-CF3Ph (3-CIPh)CH2OCH2 H
G6-1075 4-CF3Ph (4-CIPh)CH2OCH2 H
G6-1076 4-CF3Ph (2-BrPh)CH2OCH2 H
G6-1077 4-CF3Ph (3-BrPh)CH2OCH2 H
G6-1078 4-CF3Ph (4-BrPh)CH2OCH2 H
G6-1079 4-CF3Ph (2-CF3OPh)CH2OCH2 H
G6-1080 4-CF3Ph (3-CF3OPh)CH2OCH2 H
G6-1081 4-CF3Ph (4-CF3OPh)CH2OCH2 H
G6-1082 4-CF3Ph (2-CNPh)CH2OCH2 H
G6-1083 4-CF3Ph (3-CNPh)CH2OCH2 H
G6-1084 4-CF3Ph (4-CNPh)CH2OCH2 H
G6-1085 4-CF3Ph (2-N02Ph)CH2OCH2 H
G6-1086 4-CF3Ph (3-N02Ph)CH2OCH2 H
G6-1087 4-CF3Ph (4-N02Ph)CH2OCH2 H
G6-1088 4-CF3Ph (2-CF3Ph)CH2OCH2 H
G6-1089 4-CF3Ph (3-CF3Ph)CH2OCH2 H
G6-1090 4-CF3Ph (4-CF3Ph)CH2OCH2 H
G6-1091 4-CF3Ph CH3C(=0)OCH2 H
G6-1092 4-CF3Ph CH3CH2C(=0)OCH2 H
G6-1093 4-CF3Ph CH(CH3)2C(=0)OCH2 H
G6-1094 4-CF3Ph (CH3)3C(=0)OCH2 H
G6-1095 4-CF3Ph (CH3)3CCH2(=0)OCH2 H
G6-1096 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 H
G6-1097 4-CF3Ph CF3C(=0)OCH2 H
G6-1098 4-CF3Ph CF3CF2C(=0)OCH2 H
G6-1099 4-CF3Ph (c-hex)C(=0)OCH2 H
G6-1100 4-CF3Ph PhC(=0)OCH2 H
G6-1101 4-CF3Ph (2-CH3Ph)C(=0)OCH2 H
G6-1102 4-CF3Ph (3-CH3Ph)C(=0)OCH2 H
G6-1103 4-CF3Ph (4-CH3Ph)C(=0)OCH2 H
G6-1104 4-CF3Ph (2-CH3OPh)C(=0)OCH2 H
G6-1105 4-CF3Ph (3-CH3OPh)C(=0)OCH2 H
G6-1106 4-CF3Ph (4-CH3OPh)C(=0)OCH2 H
G6-1107 4-CF3Ph (2-FPh)C(=0)OCH2 H
G6-1108 4-CF3Ph (3-FPh)C(=0)OCH2 H
G6-1109 4-CF3Ph (4-FPh)C(=0)OCH2 H
G6-1110 4-CF3Ph (2-CIPh)C(=0)OCH2 H
G6-1111 4-CF3Ph (3-CIPh)C(=0)OCH2 H
G6-1112 4-CF3Ph (4-CIPh)C(=0)OCH2 H
G6-1113 4-CF3Ph (2-BrPh)C(=0)OCH2 H
G6-1114 4-CF3Ph (3-BrPh)C(=0)OCH2 H
G6-1115 4-CF3Ph (4-BrPh)C(=0)OCH2 H
G6-1116 4-CF3Ph (2-CF3OPh)C(=0)OCH2 H
G6-1117 4-CF3Ph (3-CF3OPh)C(=0)OCH2 H
G6-1118 4-CF3Ph (4-CF3OPh)C(=0)OCH2 H
G6-1119 4-CF3Ph (2-CNPh)C(=0)OCH2 H
G6-1120 4-CF3Ph (3-CNPh)C(=0)OCH2 H
G6-1121 4-CF3Ph (4-CNPh)C(=0)OCH2 H
G6-1122 4-CF3Ph (2-N02Ph)C(=0)OCH2 H
G6-1123 4-CF3Ph (3-N02Ph)C(=0)OCH2 H
G6-1124 4-CF3Ph (4-N02Ph)C(=0)OCH2 H
G6-1125 4-CF3Ph (2-CF3Ph)C(=0)OCH2 H
G6-1126 4-CF3Ph (3-CF3Ph)C(=0)OCH2 H
G6-1127 4-CF3Ph (4-CF3Ph)C(=0)OCH2 H
G6-1128 4-CF3Ph CH3 CH3
G6-1129 4-CF3Ph CH3CH2 CH3
G6-1130 4-CF3Ph CH3CH2CH2 CH3
G6-1131 4-CF3Ph (CH3)2CH CH3
G6-1132 4-CF3Ph CH3C(=0) CH3
G6-1133 4-CF3Ph CH3CH2C(=0) CH3
G6-1134 4-CF3Ph (CH3)2CHC(=0) CH3
G6-1135 4-CF3Ph (CH3)3CC(=0) CH3
G6-1136 4-CF3Ph (CH3)3CCH2C(=0) CH3
G6-1137 4-CF3Ph CH3CH2CH(CH3)C(=0) CH3
G6-1138 4-CF3Ph (CH3)2CHCH2C(=0) CH3
G6-1139 4-CF3Ph (CH3)3CCH2CH2C(=0) CH3
G6-1140 4-CF3Ph CH3CH2C(CH3)2C(=0) CH3
G6-1141 4-CF3Ph (c-hex)C(=0) CH3
G6-1142 4-CF3Ph (c-pen)C(=0) CH3
G6-1143 4-CF3Ph (c-hep)C(=0) CH3
G6-1144 4-CF3Ph (c-pro)C(=0) CH3
G6-1145 4-CF3Ph CF3C(=0) CH3
G6-1146 4-CF3Ph (CH3)2NC(=0) CH3
G6-1147 4-CF3Ph (CH3CH2)2NC(=0) CH3
G6-1148 4-CF3Ph (CH3CH2CH2)2NC(=0) CH3
G6-1149 4-CF3Ph CH3CH2N(CH3)C(=0) CH3
G6-1150 4-CF3Ph [(CH3)2CHCH2]2NC(=0) CH3
G6-1151 4-CF3Ph CH3ON(CH3)C(=0) CH3
G6-1152 4-CF3Ph (CH2=CHCH2)2N C(=0) CH3
G6-1153 4-CF3Ph (CHCCH2)2NC(=0) CH3
G6-1154 4-CF3Ph CH3
G6-1155 4-CF3Ph CH3
G6-1156 4-CF3Ph CH3
G6-1157 4-CF3Ph CH3OCH2 CH3
G6-1158 4-CF3Ph CH3CH2OCH2 CH3
G6-1159 4-CF3Ph (CH3)2CHOCH2 CH3
G6-1160 4-CF3Ph (CH3)3COCH2 CH3
G6-1161 4-CF3Ph (CH3)3CCH2OCH2 CH3
G6-1162 4-CF3Ph CH3CH2C(CH3)2OCH2 CH3
G6-1163 4-CF3Ph (c-hex)OCH2 CH3
G6-1164 4-CF3Ph PhOCH2 CH3
G6-1165 4-CF3Ph (2-CH3Ph)OCH2 CH3
G6-1166 4-CF3Ph (3-CH3Ph)OCH2 CH3
G6-1167 4-CF3Ph (4-CH3Ph)OCH2 CH3
G6-1168 4-CF3Ph (2-CH3OPh)OCH2 CH3
G6-1169 4-CF3Ph (3-CH3OPh)OCH2 CH3
G6-1170 4-CF3Ph (4-CH3OPh)OCH2 CH3
G6-1171 4-CF3Ph (2-FPh)OCH2 CH3
G6-1172 4-CF3Ph (3-FPh)OCH2 CH3
G6-1173 4-CF3Ph (4-FPh)OCH2 CH3
G6-1174 4-CF3Ph (2-CIPh)OCH2 CH3
G6-1175 4-CF3Ph (3-CIPh)OCH2 CH3
G6-1176 4-CF3Ph (4-CIPh)OCH2 CH3
G6-1177 4-CF3Ph (2-BrPh)OCH2 CH3
G6-1178 4-CF3Ph (3-BrPh)OCH2 CH3
G6-1179 4-CF3Ph (4-BrPh)OCH2 CH3
G6-1180 4-CF3Ph (2-CF3OPh)OCH2 CH3
G6-1181 4-CF3Ph (3-CF3OPh)OCH2 CH3
G6-1182 4-CF3Ph (4-CF3OPh)OCH2 CH3
G6-1183 4-CF3Ph (2-CNPh)OCH2 CH3
G6-1184 4-CF3Ph (3-CNPh)OCH2 CH3
G6-1185 4-CF3Ph (4-CNPh)OCH2 CH3
G6-1186 4-CF3Ph (2-N02Ph)OCH2 CH3
G6-1187 4-CF3Ph (3-N02Ph)OCH2 CH3
G6-1188 4-CF3Ph (4-N02Ph)OCH2 CH3
G6-1189 4-CF3Ph (2-CF3Ph)OCH2 CH3
G6-1190 4-CF3Ph (3-CF3Ph)OCH2 CH3
G6-1191 4-CF3Ph (4-CF3Ph)OCH2 CH3
G6-1192 4-CF3Ph PhCH2OCH2 CH3
G6-1193 4-CF3Ph (2-CH3Ph)CH2OCH2 CH3
G6-1194 4-CF3Ph (3-CH3Ph)CH2OCH2 CH3
G6-1195 4-CF3Ph (4-CH3Ph)CH2OCH2 CH3
G6-1196 4-CF3Ph (2-CH3OPh)CH2OCH2 CH3
G6-1197 4-CF3Ph (3-CH3OPh)CH2OCH2 CH3
G6-1198 4-CF3Ph (4-CH3OPh)CH2OCH2 CH3
G6-1199 4-CF3Ph (2-FPh)CH2OCH2 CH3
G6-1200 4-CF3Ph (3-FPh)CH2OCH2 CH3
G6-1201 4-CF3Ph (4-FPh)CH2OCH2 CH3
G6-1202 4-CF3Ph (2-CIPh)CH2OCH2 CH3
G6-1203 4-CF3Ph (3-CIPh)CH2OCH2 CH3
G6-1204 4-CF3Ph (4-CIPh)CH2OCH2 CH3
G6-1205 4-CF3Ph (2-BrPh)CH2OCH2 CH3
G6-1206 4-CF3Ph (3-BrPh)CH2OCH2 CH3
G6-1207 4-CF3Ph (4-BrPh)CH2OCH2 CH3
G6-1208 4-CF3Ph (2-CF3OPh)CH2OCH2 CH3
G6-1209 4-CF3Ph (3-CF3OPh)CH2OCH2 CH3
G6-1210 4-CF3Ph (4-CF3OPh)CH2OCH2 CH3
G6-1211 4-CF3Ph (2-CNPh)CH2OCH2 CH3
G6-1212 4-CF3Ph (3-CNPh)CH2OCH2 CH3
G6-1213 4-CF3Ph (4-CNPh)CH2OCH2 CH3
G6-1214 4-CF3Ph (2-N02Ph)CH2OCH2 CH3
G6-1215 4-CF3Ph (3-N02Ph)CH2OCH2 CH3
G6-1216 4-CF3Ph (4-N02Ph)CH2OCH2 CH3
G6-1217 4-CF3Ph (2-CF3Ph)CH2OCH2 CH3
G6-1218 4-CF3Ph (3-CF3Ph)CH2OCH2 CH3
G6-1219 4-CF3Ph (4-CF3Ph)CH2OCH2 CH3
G6-1220 4-CF3Ph CH3C(=0)OCH2 CH3
G6-1221 4-CF3Ph CH3CH2C(=0)OCH2 CH3
G6-1222 4-CF3Ph CH(CH3)2C(=0)OCH2 CH3
G6-1223 4-CF3Ph (CH3)3C(=0)OCH2 CH3
G6-1224 4-CF3Ph (CH3)3CCH2(=0)OCH2 CH3
G6-1225 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G6-1226 4-CF3Ph CF3C(=0)OCH2 CH3
G6-1227 4-CF3Ph CF3CF2C(=0)OCH2 CH3
G6-1228 4-CF3Ph (c-hex)C(=0)OCH2 CH3
G6-1229 4-CF3Ph PhC(=0)OCH2 CH3
G6-1230 4-CF3Ph (2-CH3Ph)C(=0)OCH2 CH3
G6-1231 4-CF3Ph (3-CH3Ph)C(=0)OCH2 CH3
G6-1232 4-CF3Ph (4-CH3Ph)C(=0)OCH2 CH3
G6-1233 4-CF3Ph (2-CH3OPh)C(=0)OCH2 CH3
G6-1234 4-CF3Ph (3-CH3OPh)C(=0)OCH2 CH3
G6-1235 4-CF3Ph (4-CH3OPh)C(=0)OCH2 CH3
G6-1236 4-CF3Ph (2-FPh)C(=0)OCH2 CH3
G6-1237 4-CF3Ph (3-FPh)C(=0)OCH2 CH3
G6-1238 4-CF3Ph (4-FPh)C(=0)OCH2 CH3
G6-1239 4-CF3Ph (2-CIPh)C(=0)OCH2 CH3
G6-1240 4-CF3Ph (3-CIPh)C(=0)OCH2 CH3
G6-1241 4-CF3Ph (4-CIPh)C(=0)OCH2 CH3
G6-1242 4-CF3Ph (2-BrPh)C(=0)OCH2 CH3
G6-1243 4-CF3Ph (3-BrPh)C(=0)OCH2 CH3
G6-1244 4-CF3Ph (4-BrPh)C(=0)OCH2 CH3
G6-1245 4-CF3Ph (2-CF3OPh)C(=0)OCH2 CH3
G6-1246 4-CF3Ph (3-CF3OPh)C(=0)OCH2 CH3
G6-1247 4-CF3Ph (4-CF3OPh)C(=0)OCH2 CH3
G6-1248 4-CF3Ph (2-CNPh)C(=0)OCH2 CH3
G6-1249 4-CF3Ph (3-CNPh)C(=0)OCH2 CH3
G6-1250 4-CF3Ph (4-CNPh)C(=0)OCH2 CH3
G6-1251 4-CF3Ph (2-N02Ph)C(=0)OCH2 CH3
G6-1252 4-CF3Ph (3-N02Ph)C(=0)OCH2 CH3
G6-1253 4-CF3Ph (4-N02Ph)C(=0)OCH2 CH3
G6-1254 4-CF3Ph (2-CF3Ph)C(=0)OCH2 CH3
G6-1255 4-CF3Ph (3-CF3Ph)C(=0)OCH2 CH3
G6-1256 4-CF3Ph (4-CF3Ph)C(=0)OCH2 CH3
G6-1257 3,5-(CF3)2Ph CH3 H
G6-1258 3,5-(CF3)2Ph CH3CH2 H
G6-1259 3,5-(CF3)2Ph CH3CH2CH2 H
G6-1260 3,5-(CF3)2Ph (CH3)2CH H
G6-1261 3,5-(CF3)2Ph CH3C(=0) H
G6-1305 3,5-(CF3)2Ph (4-CIPh)OCH2 H
G6-1306 3,5-(CF3)2Ph (2-BrPh)OCH2 H
G6-1307 3,5-(CF3)2Ph (3-BrPh)OCH2 H
G6-1308 3,5-(CF3)2Ph (4-BrPh)OCH2 H
G6-1309 3,5-(CF3)2Ph (2-CF3OPh)OCH2 H
G6-1310 3,5-(CF3)2Ph (3-CF3OPh)OCH2 H
G6-1311 3,5-(CF3)2Ph (4-CF3OPh)OCH2 H
G6-1312 3,5-(CF3)2Ph (2-CNPh)OCH2 H
G6-1313 3,5-(CF3)2Ph (3-CNPh)OCH2 H
G6-1314 3,5-(CF3)2Ph (4-CNPh)OCH2 H
G6-1315 3,5-(CF3)2Ph (2-N02Ph)OCH2 H
G6-1316 3,5-(CF3)2Ph (3-N02Ph)OCH2 H
G6-1317 3,5-(CF3)2Ph (4-N02Ph)OCH2 H
G6-1318 3,5-(CF3)2Ph (2-CF3Ph)OCH2 H
G6-1319 3,5-(CF3)2Ph (3-CF3Ph)OCH2 H
G6-1320 3,5-(CF3)2Ph (4-CF3Ph)OCH2 H
G6-1321 3,5-(CF3)2Ph PhCH2OCH2 H
G6-1322 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2 H
G6-1323 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2 H
G6-1324 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2 H
G6-1325 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2 H
G6-1326 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 H
G6-1327 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 H
G6-1328 3,5-(CF3)2Ph (2-FPh)CH2OCH2 H
G6-1329 3,5-(CF3)2Ph (3-FPh)CH2OCH2 H
G6-1330 3,5-(CF3)2Ph (4-FPh)CH2OCH2 H
G6-1331 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 H
G6-1332 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 H
G6-1333 3,5-(CF3)2Ph (4-CIPh)CH2OCH2 H
G6-1334 3,5-(CF3)2Ph (2-BrPh)CH2OCH2 H
G6-1335 3,5-(CF3)2Ph (3-BrPh)CH2OCH2 H
G6-1336 3,5-(CF3)2Ph (4-BrPh)CH2OCH2 H
G6-1337 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2 H
G6-1338 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2 H
G6-1339 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2 H
G6-1340 3,5-(CF3)2Ph (2-CNPh)CH2OCH2 H
G6-1341 3,5-(CF3)2Ph (3-CNPh)CH2OCH2 H
G6-1342 3,5-(CF3)2Ph (4-CNPh)CH2OCH2 H
G6-1343 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2 H
G6-1344 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2 H
G6-1345 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2 H
G6-1346 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2 H
G6-1347 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2 H
G6-1348 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2 H
G6-1349 3,5-(CF3)2Ph CH3C(=0)OCH2 H
G6-1350 3,5-(CF3)2Ph CH3CH2C(=0)OCH2 H
G6-1351 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2 H
G6-1352 3,5-(CF3)2Ph (CH3)3C(=0)OCH2 H
G6-1353 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2 H
G6-1354 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2 H
G6-1355 3,5-(CF3)2Ph CF3C(=0)OCH2 H
G6-1356 3,5-(CF3)2Ph CF3CF2C(=0)OCH2 H
G6-1357 3,5-(CF3)2Ph (c-hex)C(=0)OCH2 H
G6-1358 3,5-(CF3)2Ph PhC(=0)OCH2 H
G6-1359 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2 H
G6-1360 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2 H
G6-1361 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2 H
G6-1362 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2 H
G6-1363 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2 H
G6-1364 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2 H
G6-1365 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2 H
G6-1366 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2 H
G6-1367 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2 H
G6-1368 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2 H
G6-1369 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2 H
G6-1370 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2 H
G6-1371 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2 H
G6-1372 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2 H
G6-1373 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2 H
G6-1374 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2 H
G6-1375 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2 H
G6-1376 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2 H
G6-1377 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2 H
G6-1378 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2 H
G6-1379 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2 H
G6-1380 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2 H
G6-1381 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2 H
G6-1382 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2 H
G6-1383 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2 H
G6-1384 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2 H
G6-1385 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2 H
G6-1386 3,5-(CF3)2Ph CH3 CH3
G6-1387 3,5-(CF3)2Ph CH3CH2 CH3
G6-1388 3,5-(CF3)2Ph CH3CH2CH2 CH3
G6-1389 3,5-(CF3)2Ph (CH3)2CH CH3
G6-1390 3,5-(CF3)2Ph CH3C(=0) CH3
G6-1391 3,5-(CF3)2Ph CH3CH2C(=0) CH3
G6-1392 3,5-(CF3)2Ph (CH3)2CHC(=0) CH3
G6-1393 3,5-(CF3)2Ph (CH3)3CC(=0) CH3
G6-1394 3,5-(CF3)2Ph (CH3)3CCH2C(=0) CH3
G6-1395 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0) CH3
G6-1396 3,5-(CF3)2Ph (CH3)2CHCH2C(=0) CH3
G6-1397 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0) CH3
G6-1398 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0) CH3
G6-1399 3,5-(CF3)2Ph (c-hex)C(=0) CH3
G6-1400 3,5-(CF3)2Ph (c-pen)C(=0) CH3
G6-1401 3,5-(CF3)2Ph (c-hep)C(=0) CH3
G6-1402 3,5-(CF3)2Ph (c-pro)C(=0) CH3
G6-1403 3,5-(CF3)2Ph CF3C(=0) CH3
G6-1404 3,5-(CF3)2Ph (CH3)2NC(=0) CH3
G6-1405 3,5-(CF3)2Ph (CH3CH2)2NC(=0) CH3
G6-1406 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0) CH3
G6-1407 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0) CH3
G6-1408 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0) CH3
G6-1409 3,5-(CF3)2Ph CH3ON(CH3)C(=0) CH3
G6-1410 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0) CH3
G6-1411 3,5-(CF3)2Ph (CHCCH2)2NC(=0) CH3
CO-N^]
G6-1412 3,5-(CF3)2Ph CH3
CO-N^
G6-1413 3,5-(CF3)2Ph CH3
CO-N^O
G6-1414 3 5-(CF3)2Ph CH3
G6-1415 3 5-(CF3)2Ph CH3OCH2 CH3
G6-1416 3 5-(CF3)2Ph CH3CH2OCH2 CH3
G6-1417 3 5-(CF3)2Ph (CH3)2CHOCH2 CH3
G6-1418 3 5-(CF3)2Ph (CH3)3COCH2 CH3
G6-1419 3 5-(CF3)2Ph (CH3)3CCH2OCH2 CH3
G6-1420 3 5-(CF3)2Ph CH3CH2C(CH3)2OCH2 CH3
G6-1421 3 5-(CF3)2Ph (c-hex)OCH2 CH3
G6-1422 3 5-(CF3)2Ph PhOCH2 CH3
G6-1423 3 5-(CF3)2Ph (2-CH3Ph)OCH2 CH3
G6-1424 3 5-(CF3)2Ph (3-CH3Ph)OCH2 CH3
G6-1425 3 5-(CF3)2Ph (4-CH3Ph)OCH2 CH3
G6-1426 3 5-(CF3)2Ph (2-CH3OPh)OCH2 CH3
G6-1427 3 5-(CF3)2Ph (3-CH3OPh)OCH2 CH3
G6-1428 3 5-(CF3)2Ph (4-CH3OPh)OCH2 CH3
G6-1429 3 5-(CF3)2Ph (2-FPh)OCH2 CH3
G6-1430 3 5-(CF3)2Ph (3-FPh)OCH2 CH3
G6-1431 3 5-(CF3)2Ph (4-FPh)OCH2 CH3
G6-1432 3 5-(CF3)2Ph (2-CIPh)OCH2 CH3
G6-1433 3 5-(CF3)2Ph (3-CIPh)OCH2 CH3
G6-1434 3 5-(CF3)2Ph (4-CIPh)OCH2 CH3
G6-1435 3 5-(CF3)2Ph (2-BrPh)OCH2 CH3
G6-1436 3 5-(CF3)2Ph (3-BrPh)OCH2 CH3
G6-1437 3 5-(CF3)2Ph (4-BrPh)OCH2 CH3
G6-1438 3 5-(CF3)2Ph (2-CF3OPh)OCH2 CH3
G6-1439 3 5-(CF3)2Ph (3-CF3OPh)OCH2 CH3
G6-1440 3 5-(CF3)2Ph (4-CF3OPh)OCH2 CH3
G6-1441 3 5-(CF3)2Ph (2-CNPh)OCH2 CH3
G6-1442 3,5-(CF3)2Ph (3-CNPh)OCH2 CH3
G6-1443 3,5-(CF3)2Ph (4-CNPh)OCH2 CH3
G6-1444 3,5-(CF3)2Ph (2-N02Ph)OCH2 CH3
G6-1445 3,5-(CF3)2Ph (3-N02Ph)OCH2 CH3
G6-1446 3,5-(CF3)2Ph (4-N02Ph)OCH2 CH3
G6-1447 3,5-(CF3)2Ph (2-CF3Ph)OCH2 CH3
G6-1448 3,5-(CF3)2Ph (3-CF3Ph)OCH2 CH3
G6-1449 3,5-(CF3)2Ph (4-CF3Ph)OCH2 CH3
G6-1450 3,5-(CF3)2Ph PhCH2OCH2 CH3
G6-1451 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2 CH3
G6-1452 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2 CH3
G6-1453 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2 CH3
G6-1454 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2 CH3
G6-1455 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2 CH3
G6-1456 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2 CH3
G6-1457 3,5-(CF3)2Ph (2-FPh)CH2OCH2 CH3
G6-1458 3,5-(CF3)2Ph (3-FPh)CH2OCH2 CH3
G6-1459 3,5-(CF3)2Ph (4-FPh)CH2OCH2 CH3
G6-1460 3,5-(CF3)2Ph (2-CIPh)CH2OCH2 CH3
G6-1461 3,5-(CF3)2Ph (3-CIPh)CH2OCH2 CH3
G6-1462 3,5-(CF3)2Ph (4-CIPh)CH2OCH2 CH3
G6-1463 3,5-(CF3)2Ph (2-BrPh)CH2OCH2 CH3
G6-1464 3,5-(CF3)2Ph (3-BrPh)CH2OCH2 CH3
G6-1465 3,5-(CF3)2Ph (4-BrPh)CH2OCH2 CH3
G6-1466 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2 CH3
G6-1467 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2 CH3
G6-1468 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2 CH3
G6-1469 3,5-(CF3)2Ph (2-CNPh)CH2OCH2 CH3
G6-1470 3,5-(CF3)2Ph (3-CNPh)CH2OCH2 CH3
G6-1471 3,5-(CF3)2Ph (4-CNPh)CH2OCH2 CH3
G6-1472 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2 CH3
G6-1473 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2 CH3
G6-1474 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2 CH3
G6-1475 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2 CH3
G6-1476 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2 CH3
G6-1477 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2 CH3
G6-1478 3,5-(CF3)2Ph CH3C(=0)OCH2 CH3
G6-1479 3,5-(CF3)2Ph CH3CH2C(=0)OCH2 CH3
G6-1480 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2 CH3
G6-1481 3,5-(CF3)2Ph (CH3)3C(=0)OCH2 CH3
G6-1482 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2 CH3
G6-1483 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2 CH3
G6-1484 3,5-(CF3)2Ph CF3C(=0)OCH2 CH3
G6-1485 3,5-(CF3)2Ph CF3CF2C(=0)OCH2 CH3
G6-1486 3,5-(CF3)2Ph (c-hex)C(=0)OCH2 CH3
G6-1487 3,5-(CF3)2Ph PhC(=0)OCH2 CH3
G6-1488 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2 CH3
G6-1489 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2 CH3
G6-1490 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2 CH3
G6-1491 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2 CH3
G6-1492 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2 CH3
G6-1493 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2 CH3
G6-1494 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2 CH3
G6-1495 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2 CH3
G6-1496 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2 CH3
G6-1497 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2 CH3
G6-1498 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2 CH3
G6-1499 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2 CH3
G6-1500 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2 CH3
G6-1501 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2 CH3
G6-1502 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2 CH3
G6-1503 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2 CH3
G6-1504 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2 CH3
G6-1505 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2 CH3
G6-1506 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2 CH3
G6-1507 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2 CH3
G6-1508 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2 CH3
G6-1509 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2 CH3
G6-1510 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2 CH3
G6-1511 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2 CH3
G6-1512 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2 CH3
G6-1513 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2 CH3
G6-1514 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2 CH3
[0300] [Table 7]
G7-288 2-CF3Ph (2-FPh)OCH2
G7-289 2-CF3Ph (3-FPh)OCH2
G7-290 2-CF3Ph (4-FPh)OCH2
G7-291 2-CF3Ph (2-CIPh)OCH2
G7-292 2-CF3Ph (3-CIPh)OCH2
G7-293 2-CF3Ph (4-CIPh)OCH2
G7-294 2-CF3Ph (2-BrPh)OCH2
G7-295 2-CF3Ph (3-BrPh)OCH2
G7-296 2-CF3Ph (4-BrPh)OCH2
G7-297 2-CF3Ph (2-CF3OPh)OCH2
G7-298 2-CF3Ph (3-CF3OPh)OCH2
G7-299 2-CF3Ph (4-CF3OPh)OCH2
G7-300 2-CF3Ph (2-CNPh)OCH2
G7-301 2-CF3Ph (3-CNPh)OCH2
G7-302 2-CF3Ph (4-CNPh)OCH2
G7-303 2-CF3Ph (2-N02Ph)OCH2
G7-304 2-CF3Ph (3-N02Ph)OCH2
G7-305 2-CF3Ph (4-N02Ph)OCH2
G7-306 2-CF3Ph (2-CF3Ph)OCH2
G7-307 2-CF3Ph (3-CF3Ph)OCH2
G7-308 2-CF3Ph (4-CF3Ph)OCH2
G7-309 2-CF3Ph PhCH2OCH2
G7-310 2-CF3Ph (2-CH3Ph)CH2OCH2
G7-311 2-CF3Ph (3-CH3Ph)CH2OCH2
G7-312 2-CF3Ph (4-CH3Ph)CH2OCH2
G7-313 2-CF3Ph (2-CH3OPh)CH2OCH2
G7-314 2-CF3Ph (3-CH3OPh)CH2OCH2
G7-315 2-CF3Ph (4-CH3OPh)CH2OCH2
G7-316 2-CF3Ph (2-FPh)CH2OCH2
G7-317 2-CF3Ph (3-FPh)CH2OCH2
G7-318 2-CF3Ph (4-FPh)CH2OCH2
G7-319 2-CF3Ph (2-CIPh)CH2OCH2
G7-320 2-CF3Ph (3-CIPh)CH2OCH2
G7-321 2-CF3Ph (4-CIPh)CH2OCH2
G7-322 2-CF3Ph (2-BrPh)CH2OCH2
G7-323 2-CF3Ph (3-BrPh)CH2OCH2
G7-324 2-CF3Ph (4-BrPh)CH2OCH2
G7-325 2-CF3Ph (2-CF3OPh)CH2OCH2
G7-326 2-CF3Ph (3-CF3OPh)CH2OCH2
G7-327 2-CF3Ph (4-CF3OPh)CH2OCH2
G7-328 2-CF3Ph (2-CNPh)CH2OCH2
G7-329 2-CF3Ph (3-CNPh)CH2OCH2
G7-330 2-CF3Ph (4-CNPh)CH2OCH2
G7-331 2-CF3Ph (2-N02Ph)CH2OCH2
G7-332 2-CF3Ph (3-N02Ph)CH2OCH2
G7-333 2-CF3Ph (4-N02Ph)CH2OCH2
G7-426 3-CF3Ph (2-CF3OPh)OCH2
G7-427 3-CF3Ph (3-CF3OPh)OCH2
G7-428 3-CF3Ph (4-CF3OPh)OCH2
G7-429 3-CF3Ph (2-CNPh)OCH2
G7-430 3-CF3Ph (3-CNPh)OCH2
G7-431 3-CF3Ph (4-CNPh)OCH2
G7-432 3-CF3Ph (2-N02Ph)OCH2
G7-433 3-CF3Ph (3-N02Ph)OCH2
G7-434 3-CF3Ph (4-N02Ph)OCH2
G7-435 3-CF3Ph (2-CF3Ph)OCH2
G7-436 3-CF3Ph (3-CF3Ph)OCH2
G7-437 3-CF3Ph (4-CF3Ph)OCH2
G7-438 3-CF3Ph PhCH2OCH2
G7-439 3-CF3Ph (2-CH3Ph)CH2OCH2
G7-440 3-CF3Ph (3-CH3Ph)CH2OCH2
G7-441 3-CF3Ph (4-CH3Ph)CH2OCH2
G7-442 3-CF3Ph (2-CH3OPh)CH2OCH2
G7-443 3-CF3Ph (3-CH3OPh)CH2OCH2
G7-444 3-CF3Ph (4-CH3OPh)CH2OCH2
G7-445 3-CF3Ph (2-FPh)CH2OCH2
G7-446 3-CF3Ph (3-FPh)CH2OCH2
G7-447 3-CF3Ph (4-FPh)CH2OCH2
G7-448 3-CF3Ph (2-CIPh)CH2OCH2
G7-449 3-CF3Ph (3-CIPh)CH2OCH2
G7-450 3-CF3Ph (4-CIPh)CH2OCH2
G7-451 3-CF3Ph (2-BrPh)CH2OCH2
G7-452 3-CF3Ph (3-BrPh)CH2OCH2
G7-453 3-CF3Ph (4-BrPh)CH2OCH2
G7-454 3-CF3Ph (2-CF3OPh)CH2OCH2
G7-455 3-CF3Ph (3-CF3OPh)CH2OCH2
G7-456 3-CF3Ph (4-CF3OPh)CH2OCH2
G7-457 3-CF3Ph (2-CNPh)CH2OCH2
G7-458 3-CF3Ph (3-CNPh)CH2OCH2
G7-459 3-CF3Ph (4-CNPh)CH2OCH2
G7-460 3-CF3Ph (2-N02Ph)CH2OCH2
G7-461 3-CF3Ph (3-N02Ph)CH2OCH2
G7-462 3-CF3Ph (4-N02Ph)CH2OCH2
G7-463 3-CF3Ph (2-CF3Ph)CH2OCH2
G7-464 3-CF3Ph (3-CF3Ph)CH2OCH2
G7-465 3-CF3Ph (4-CF3Ph)CH2OCH2
G7-466 3-CF3Ph CH3C(=0)OCH2
G7-467 3-CF3Ph CH3CH2C(=0)OCH2
G7-468 3-CF3Ph CH(CH3)2C(=0)OCH2
G7-469 3-CF3Ph (CH3)3C(=0)OCH2
G7-470 3-CF3Ph (CH3)3CCH2(=0)OCH2
G7-471 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G7-564 4-CF3Ph (2-CF3Ph)OCH2
G7-565 4-CF3Ph (3-CF3Ph)OCH2
G7-566 4-CF3Ph (4-CF3Ph)OCH2
G7-567 4-CF3Ph PhCH2OCH2
G7-568 4-CF3Ph (2-CH3Ph)CH2OCH2
G7-569 4-CF3Ph (3-CH3Ph)CH2OCH2
G7-570 4-CF3Ph (4-CH3Ph)CH2OCH2
G7-571 4-CF3Ph (2-CH3OPh)CH2OCH2
G7-572 4-CF3Ph (3-CH3OPh)CH2OCH2
G7-573 4-CF3Ph (4-CH3OPh)CH2OCH2
G7-574 4-CF3Ph (2-FPh)CH2OCH2
G7-575 4-CF3Ph (3-FPh)CH2OCH2
G7-576 4-CF3Ph (4-FPh)CH2OCH2
G7-577 4-CF3Ph (2-CIPh)CH2OCH2
G7-578 4-CF3Ph (3-CIPh)CH2OCH2
G7-579 4-CF3Ph (4-CIPh)CH2OCH2
G7-580 4-CF3Ph (2-BrPh)CH2OCH2
G7-581 4-CF3Ph (3-BrPh)CH2OCH2
G7-582 4-CF3Ph (4-BrPh)CH2OCH2
G7-583 4-CF3Ph (2-CF3OPh)CH2OCH2
G7-584 4-CF3Ph (3-CF3OPh)CH2OCH2
G7-585 4-CF3Ph (4-CF3OPh)CH2OCH2
G7-586 4-CF3Ph (2-CNPh)CH2OCH2
G7-587 4-CF3Ph (3-CNPh)CH2OCH2
G7-588 4-CF3Ph (4-CNPh)CH2OCH2
G7-589 4-CF3Ph (2-N02Ph)CH2OCH2
G7-590 4-CF3Ph (3-N02Ph)CH2OCH2
G7-591 4-CF3Ph (4-N02Ph)CH2OCH2
G7-592 4-CF3Ph (2-CF3Ph)CH2OCH2
G7-593 4-CF3Ph (3-CF3Ph)CH2OCH2
G7-594 4-CF3Ph (4-CF3Ph)CH2OCH2
G7-595 4-CF3Ph CH3C(=0)OCH2
G7-596 4-CF3Ph CH3CH2C(=0)OCH2
G7-597 4-CF3Ph CH(CH3)2C(=0)OCH2
G7-598 4-CF3Ph (CH3)3C(=0)OCH2
G7-599 4-CF3Ph (CH3)3CCH2(=0)OCH2
G7-600 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G7-601 4-CF3Ph CF3C(=0)OCH2
G7-602 4-CF3Ph CF3CF2C(=0)OCH2
G7-603 4-CF3Ph (c-hex)C(=0)OCH2
G7-604 4-CF3Ph PhC(=0)OCH2
G7-605 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G7-606 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G7-607 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G7-608 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G7-609 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G7-610 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G7-611 4-CF3Ph (2-FPh)C(=0)OCH2
G7-612 4-CF3Ph (3-FPh)C(=0)OCH2
G7-613 4-CF3Ph (4-FPh)C(=0)OCH2
G7-614 4-CF3Ph (2-CIPh)C(=0)OCH2
G7-615 4-CF3Ph (3-CIPh)C(=0)OCH2
G7-616 4-CF3Ph (4-CIPh)C(=0)OCH2
G7-617 4-CF3Ph (2-BrPh)C(=0)OCH2
G7-618 4-CF3Ph (3-BrPh)C(=0)OCH2
G7-619 4-CF3Ph (4-BrPh)C(=0)OCH2
G7-620 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G7-621 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G7-622 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G7-623 4-CF3Ph (2-CNPh)C(=0)OCH2
G7-624 4-CF3Ph (3-CNPh)C(=0)OCH2
G7-625 4-CF3Ph (4-CNPh)C(=0)OCH2
G7-626 4-CF3Ph (2-N02Ph)C(=0)OCH2
G7-627 4-CF3Ph (3-N02Ph)C(=0)OCH2
G7-628 4-CF3Ph (4-N02Ph)C(=0)OCH2
G7-629 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G7-630 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G7-631 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G7-632 3,5-(CF3)2Ph CH3
G7-633 3,5-(CF3)2Ph CH3CH2
G7-634 3,5-(CF3)2Ph CH3CH2CH2
G7-635 3,5-(CF3)2Ph (CH3)2CH
G7-636 3,5-(CF3)2Ph CH3C(=0)
G7-637 3,5-(CF3)2Ph CH3CH2C(=0)
G7-638 3,5-(CF3)2Ph (CH3)2CHC(=0)
G7-639 3,5-(CF3)2Ph (CH3)3CC(=0)
G7-640 3,5-(CF3)2Ph (CH3)3CCH2C(=0)
G7-641 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0)
G7-642 3,5-(CF3)2Ph (CH3)2CHCH2C(=0)
G7-643 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0)
G7-644 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)
G7-645 3,5-(CF3)2Ph (c-hex)C(=0)
G7-646 3,5-(CF3)2Ph (c-pen)C(=0)
G7-647 3,5-(CF3)2Ph (c-hep)C(=0)
G7-648 3,5-(CF3)2Ph (c-pro)C(=0)
G7-649 3,5-(CF3)2Ph CF3C(=0)
G7-650 3,5-(CF3)2Ph (CH3)2NC(=0)
G7-651 3,5-(CF3)2Ph (CH3CH2)2NC(=0)
G7-652 3,5-(CF3)2Ph (CH3CH2CH2)2NC(=0)
G7-653 3,5-(CF3)2Ph CH3CH2N(CH3)C(=0)
G7-654 3,5-(CF3)2Ph [(CH3)2CHCH2]2NC(=0)
G7-655 3,5-(CF3)2Ph CH3ON(CH3)C(=0)
G7-656 3,5-(CF3)2Ph (CH2=CHCH2)2N C(=0)
G7-701 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G7-702 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G7-703 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G7-704 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G7-705 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G7-706 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G7-707 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G7-708 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G7-709 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G7-710 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G7-711 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G7-712 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G7-713 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G7-714 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G7-715 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G7-716 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G7-717 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G7-718 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G7-719 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G7-720 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G7-721 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G7-722 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G7-723 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G7-724 3,5-(CF3)2Ph CH3C(=0)OCH2
G7-725 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G7-726 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G7-727 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G7-728 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G7-729 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G7-730 3,5-(CF3)2Ph CF3C(=0)OCH2
G7-731 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G7-732 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G7-733 3,5-(CF3)2Ph PhC(=0)OCH2
G7-734 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G7-735 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G7-736 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G7-737 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G7-738 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G7-739 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G7-740 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G7-741 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G7-742 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G7-743 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G7-744 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G7-745 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G7-746 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G7-747 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G7-748 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G7-749 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G7-750 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G7-751 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G7-752 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G7-753 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G7-754 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G7-755 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G7-756 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G7-757 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G7-758 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G7-759 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G7-760 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0301] Table 8
G8-161 CF3 (4-CIPh)OCH2
G8-162 CF3 (2-BrPh)OCH2
G8-163 CF3 (3-BrPh)OCH2
G8-164 CF3 (4-BrPh)OCH2
G8-165 CF3 (2-CF3OPh)OCH2
G8-166 CF3 (3-CF3OPh)OCH2
G8-167 CF3 (4-CF3OPh)OCH2
G8-168 CF3 (2-CNPh)OCH2
G8-169 CF3 (3-CNPh)OCH2
G8-170 CF3 (4-CNPh)OCH2
G8-171 CF3 (2-N02Ph)OCH2
G8-172 CF3 (3-N02Ph)OCH2
G8-173 CF3 (4-N02Ph)OCH2
G8-174 CF3 (2-CF3Ph)OCH2
G8-175 CF3 (3-CF3Ph)OCH2
G8-176 CF3 (4-CF3Ph)OCH2
G8-177 CF3 PhCH2OCH2
G8-178 CF3 (2-CH3Ph)CH2OCH2
G8-179 CF3 (3-CH3Ph)CH2OCH2
G8-180 CF3 (4-CH3Ph)CH2OCH2
G8-181 CF3 (2-CH3OPh)CH2OCH2
G8-182 CF3 (3-CH3OPh)CH2OCH2
G8-183 CF3 (4-CH3OPh)CH2OCH2
G8-184 CF3 (2-FPh)CH2OCH2
G8-185 CF3 (3-FPh)CH2OCH2
G8-186 CF3 (4-FPh)CH2OCH2
G8-187 CF3 (2-CIPh)CH2OCH2
G8-188 CF3 (3-CIPh)CH2OCH2
G8-189 CF3 (4-CIPh)CH2OCH2
G8-190 CF3 (2-BrPh)CH2OCH2
G8-191 CF3 (3-BrPh)CH2OCH2
G8-192 CF3 (4-BrPh)CH2OCH2
G8-193 CF3 (2-CF3OP )CH2OCH2
G8-194 CF3 (3-CF3OPh)CH2OCH2
G8-195 CF3 (4-CF3OPh)CH2OCH2
G8-196 CF3 (2-CNPh)CH2OCH2
G8-197 CF3 (3-CNPh)CH2OCH2
G8-198 CF3 (4-CNPh)CH2OCH2
G8-199 CF3 (2-N02Ph)CH2OCH2
G8-200 CF3 (3-N02P )CH2OCH2
G8-201 CF3 (4-N02Ph)CH2OCH2
G8-202 CF3 (2-CF3Ph)CH2OCH2
G8-203 CF3 (3-CF3Ph)CH2OCH2
G8-204 CF3 (4-CF3Ph)CH2OCH2
G8-205 CF3 CH3C(=0)OCH2
G8-206 CF3 CH3CH2C(=0)OCH2
G8-299 2-CF3Ph (4-CNPh)OCH2
G8-300 2-CF3Ph (2-N02Ph)OCH2
G8-301 2-CF3Ph (3-N02Ph)OCH2
G8-302 2-CF3Ph (4-N02Ph)OCH2
G8-303 2-CF3Ph (2-CF3Ph)OCH2
G8-304 2-CF3Ph (3-CF3Ph)OCH2
G8-305 2-CF3Ph (4-CF3Ph)OCH2
G8-306 2-CF3Ph PhCH2OCH2
G8-307 2-CF3Ph (2-CH3Ph)CH2OCH2
G8-308 2-CF3Ph (3-CH3Ph)CH2OCH2
G8-309 2-CF3Ph (4-CH3Ph)CH2OCH2
G8-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G8-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G8-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G8-313 2-CF3Ph (2-FP )CH2OCH2
G8-314 2-CF3Ph (3-FPh)CH2OCH2
G8-315 2-CF3Ph (4-FPh)CH2OCH2
G8-316 2-CF3Ph (2-CIPh)CH2OCH2
G8-317 2-CF3Ph (3-CIPh)CH2OCH2
G8-318 2-CF3Ph (4-CIPh)CH2OCH2
G8-319 2-CF3Ph (2-BrPh)CH2OCH2
G8-320 2-CF3Ph (3-BrPh)CH2OCH2
G8-321 2-CF3Ph (4-BrPh)CH2OCH2
G8-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G8-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G8-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G8-325 2-CF3Ph (2-CNPh)CH2OCH2
G8-326 2-CF3Ph (3-CNPh)CH2OCH2
G8-327 2-CF3Ph (4-CNPh)CH2OCH2
G8-328 2-CF3Ph (2-N02Ph)CH2OCH2
G8-329 2-CF3Ph (3-N02Ph)CH2OCH2
G8-330 2-CF3Ph (4-N02Ph)CH2OCH2
G8-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G8-332 2-CF3Ph (3-CF3Ph)CH2OCH2
G8-333 2-CF3Ph (4-CF3Ph)CH2OCH2
G8-334 2-CF3Ph CH3C(=0)OCH2
G8-335 2-CF3Ph CH3CH2C(=0)OCH2
G8-336 2-CF3Ph CH(CH3)2C(=0)OCH2
G8-337 2-CF3Ph (CH3)3C(=0)OCH2
G8-338 2-CF3Ph (CH3)3CCH2(=0)OCH2
G8-339 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G8-340 2-CF3Ph CF3C(=0)OCH2
G8-341 2-CF3Ph CF3CF2C(=0)OCH2
G8-342 2-CF3Ph (c-hex)C(=0)OCH2
G8-343 2-CF3Ph PhC(=0)OCH2
G8-344 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G8-665 3,5-(CF3)2Ph PhOCH2
G8-666 3,5-(CF3)2Ph (2-CH3Ph)OCH2
G8-667 3,5-(CF3)2Ph (3-CH3Ph)OCH2
G8-668 3,5-(CF3)2Ph (4-CH3Ph)OCH2
G8-669 3,5-(CF3)2Ph (2-CH3OPh)OCH2
G8-670 3,5-(CF3)2Ph (3-CH3OPh)OCH2
G8-671 3,5-(CF3)2Ph (4-CH3OPh)OCH2
G8-672 3,5-(CF3)2Ph (2-FPh)OCH2
G8-673 3,5-(CF3)2Ph (3-FPh)OCH2
G8-674 3,5-(CF3)2Ph (4-FPh)OCH2
G8-675 3,5-(CF3)2Ph (2-CIPh)OCH2
G8-676 3,5-(CF3)2Ph (3-CIPh)OCH2
G8-677 3,5-(CF3)2Ph (4-CIPh)OCH2
G8-678 3,5-(CF3)2Ph (2-BrPh)OCH2
G8-679 3,5-(CF3)2Ph (3-BrPh)OCH2
G8-680 3,5-(CF3)2Ph (4-BrPh)OCH2
G8-681 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G8-682 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G8-683 3,5-(CF3)2P (4-CF3OPh)OCH2
G8-684 3,5-(CF3)2Ph (2-CNPh)OCH2
G8-685 3,5-(CF3)2Ph (3-CNPh)OCH2
G8-686 3,5-(CF3)2Ph (4-CNPh)OCH2
G8-687 3,5-(CF3)2Ph (2-N02Ph)OCH2
G8-688 3,5-(CF3)2Ph (3-N02Ph)OCH2
G8-689 3,5-(CF3)2Ph (4-N02Ph)OCH2
G8-690 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G8-691 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G8-692 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G8-693 3,5-(CF3)2Ph PhCH2OCH2
G8-694 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G8-695 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G8-696 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G8-697 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G8-698 3,5-(CF3)2Ph (3-CH3OP )CH2OCH2
G8-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G8-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G8-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G8-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G8-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G8-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G8-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G8-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G8-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G8-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G8-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G8-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G8-761 2-CIPhS H
G8-762 3-CIPhS H
G8-763 4-CIPhS H
[0302] Table 9
G9-309 2-CF3Ph (4-CH3Ph)CH2OCH2
G9-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G9-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G9-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G9-313 2-CF3Ph (2-FPh)CH2OCH2
G9-314 2-CF3Ph (3-FPh)CH2OCH2
G9-315 2-CF3Ph (4-FPh)CH2OCH2
G9-316 2-CF3Ph (2-CIPh)CH2OCH2
G9-317 2-CF3Ph (3-CIPh)CH2OCH2
G9-318 2-CF3Ph (4-CIPh)CH2OCH2
G9-319 2-CF3Ph (2-BrPh)CH2OCH2
G9-320 2-CF3Ph (3-BrPh)CH2OCH2
G9-321 2-CF3Ph (4-BrPh)CH2OCH2
G9-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G9-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G9-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G9-325 2-CF3Ph (2-CNPh)CH2OCH2
G9-326 2-CF3Ph (3-CNPh)CH2OCH2
G9-327 2-CF3Ph (4-CNPh)CH2OCH2
G9-328 2-CF3Ph (2-N02Ph)CH2OCH2
G9-329 2-CF3Ph (3-N02Ph)CH2OCH2
G9-330 2-CF3Ph (4-N02Ph)CH2OCH2
G9-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G9-332 2-CF3Ph (3-CF3Ph)CH2OCH2
G9-333 2-CF3Ph (4-CF3Ph)CH2OCH2
G9-334 2-CF3Ph CH3C(=0)OCH2
G9-335 2-CF3Ph CH3CH2C(=0)OCH2
G9-336 2-CF3Ph CH(CH3)2C(=0)OCH2
G9-337 2-CF3Ph (CH3)3C(=0)OCH2
G9-338 2-CF3Ph (CH3)3CCH2(=0)OCH2
G9-339 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G9-340 2-CF3Ph CF3C(=0)OCH2
G9-341 2-CF3Ph CF3CF2C(=0)OCH2
G9-342 2-CF3Ph (c-hex)C(=0)OCH2
G9-343 2-CF3Ph PhC(=0)OCH2
G9-344 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G9-345 2-CF3Ph (3-CH3Ph)C(=0)OCH2
G9-346 2-CF3Ph (4-CH3Ph)C(=0)OCH2
G9-347 2-CF3Ph (2-CH3OPh)C(=0)OCH2
G9-348 2-CF3Ph (3-CH3OPh)C(=0)OCH2
G9-349 2-CF3Ph (4-CH3OPh)C(=0)OCH2
G9-350 2-CF3Ph (2-FPh)C(=0)OCH2
G9-351 2-CF3Ph (3-FPh)C(=0)OCH2
G9-352 2-CF3Ph (4-FPh)C(=0)OCH2
G9-353 2-CF3Ph (2-CIPh)C(=0)OCH2
G9-354 2-CF3Ph (3-CIPh)C(=0)OCH2
G9-355 2-CF3Ph (4-CIPh)C(=0)OCH2
G9-446 3-CF3Ph (3-CIPh)CH2OCH2
G9-447 3-CF3Ph (4-CIPh)CH2OCH2
G9-448 3-CF3Ph (2-BrPh)CH2OCH2
G9-449 3-CF3Ph (3-BrPh)CH2OCH2
G9-450 3-CF3Ph (4-BrPh)CH2OCH2
G9-451 3-CF3Ph (2-CF3OPh)CH2OCH2
G9-452 3-CF3Ph (3-CF3OPh)CH2OCH2
G9-453 3-CF3Ph (4-CF3OPh)CH2OCH2
G9-454 3-CF3Ph (2-CNPh)CH2OCH2
G9-455 3-CF3Ph (3-CNPh)CH2OCH2
G9-456 3-CF3Ph (4-CNPh)CH2OCH2
G9-457 3-CF3Ph (2-N02Ph)CH2OCH2
G9-458 3-CF3Ph (3-N02Ph)CH2OCH2
G9-459 3-CF3Ph (4-N02Ph)CH2OCH2
G9-460 3-CF3Ph (2-CF3Ph)CH2OCH2
G9-461 3-CF3Ph (3-CF3Ph)CH2OCH2
G9-462 3-CF3Ph (4-CF3Ph)CH2OCH2
G9-463 3-CF3Ph CH3C(=0)OCH2
G9-464 3-CF3Ph CH3CH2C(=0)OCH2
G9-465 3-CF3Ph CH(CH3)2C(=0)OCH2
G9-466 3-CF3Ph (CH3)3C(=0)OCH2
G9-467 3-CF3Ph (CH3)3CCH2(=0)OCH2
G9-468 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G9-469 3-CF3Ph CF3C(=0)OCH2
G9-470 3-CF3Ph CF3CF2C(=0)OCH2
G9-471 3-CF3Ph (c-hex)C(=0)OCH2
G9-472 3-CF3Ph PhC(=0)OCH2
G9-473 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G9-474 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G9-475 3-CF3Ph (4-CH3Ph)C(=0)OCH2
G9-476 3-CF3Ph (2-CH3OPh)C(=0)OCH2
G9-477 3-CF3Ph (3-CH3OPh)C(=0)OCH2
G9-478 3-CF3Ph (4-CH3OPh)C(=0)OCH2
G9-479 3-CF3Ph (2-FPh)C(=0)OCH2
G9-480 3-CF3Ph (3-FPh)C(=0)OCH2
G9-481 3-CF3Ph (4-FPh)C(=0)OCH2
G9-482 3-CF3Ph (2-CIPh)C(=0)OCH2
G9-483 3-CF3Ph (3-CIPh)C(=0)OCH2
G9-484 3-CF3Ph (4-CIPh)C(=0)OCH2
G9-485 3-CF3Ph (2-BrPh)C(=0)OCH2
G9-486 3-CF3Ph (3-BrPh)C(=0)OCH2
G9-487 3-CF3Ph (4-BrPh)C(=0)OCH2
G9-488 3-CF3Ph (2-CF3OPh)C(=0)OCH2
G9-489 3-CF3Ph (3-CF3OPh)C(=0)OCH2
G9-490 3-CF3Ph (4-CF3OPh)C(=0)OCH2
G9-491 3-CF3Ph (2-CNPh)C(=0)OCH2
G9-492 3-CF3Ph (3-CNPh)C(=0)OCH2
G9-536 4-CF3Ph PhOCH2
G9-537 4-CF3Ph (2-CH3Ph)OCH2
G9-538 4-CF3Ph (3-CH3Ph)OCH2
G9-539 4-CF3Ph (4-CH3Ph)OCH2
G9-540 4-CF3Ph (2-CH3OPh)OCH2
G9-541 4-CF3Ph (3-CH3OPh)OCH2
G9-542 4-CF3Ph (4-CH3OPh)OCH2
G9-543 4-CF3Ph (2-FPh)OCH2
G9-544 4-CF3Ph (3-FPh)OCH2
G9-545 4-CF3Ph (4-FPh)OCH2
G9-546 4-CF3Ph (2-CIPh)OCH2
G9-547 4-CF3Ph (3-CIPh)OCH2
G9-548 4-CF3Ph (4-CIPh)OCH2
G9-549 4-CF3Ph (2-BrPh)OCH2
G9-550 4-CF3Ph (3-BrPh)OCH2
G9-551 4-CF3Ph (4-BrPh)OCH2
G9-552 4-CF3Ph (2-CF3OPh)OCH2
G9-553 4-CF3Ph (3-CF3OPh)OCH2
G9-554 4-CF3Ph (4-CF3OPh)OCH2
G9-555 4-CF3Ph (2-CNPh)OCH2
G9-556 4-CF3Ph (3-CNPh)OCH2
G9-557 4-CF3Ph (4-CNPh)OCH2
G9-558 4-CF3Ph (2-N02Ph)OCH2
G9-559 4-CF3Ph (3-N02Ph)OCH2
G9-560 4-CF3Ph (4-N02Ph)OCH2
G9-561 4-CF3Ph (2-CF3Ph)OCH2
G9-562 4-CF3Ph (3-CF3Ph)OCH2
G9-563 4-CF3Ph (4-CF3Ph)OCH2
G9-564 4-CF3Ph PhCH2OCH2
G9-565 4-CF3Ph (2-CH3Ph)CH2OCH2
G9-566 4-CF3Ph (3-CH3Ph)CH2OCH2
G9-567 4-CF3Ph (4-CH3Ph)CH2OCH2
G9-568 4-CF3Ph (2-CH3OPh)CH2OCH2
G9-569 4-CF3Ph (3-CH3OPh)CH2OCH2
G9-570 4-CF3Ph (4-CH3OPh)CH2OCH2
G9-571 4-CF3Ph (2-FPh)CH2OCH2
G9-572 4-CF3Ph (3-FPh)CH2OCH2
G9-573 4-CF3Ph (4-FPh)CH2OCH2
G9-574 4-CF3Ph (2-CIPh)CH2OCH2
G9-575 4-CF3Ph (3-CIPh)CH2OCH2
G9-576 4-CF3Ph (4-CIPh)CH2OCH2
G9-577 4-CF3Ph (2-BrPh)CH2OCH2
G9-578 4-CF3Ph (3-BrPh)CH2OCH2
G9-579 4-CF3Ph (4-BrPh)CH2OCH2
G9-580 4-CF3Ph (2-CF3OPh)CH2OCH2
G9-581 4-CF3Ph (3-CF3OPh)CH2OCH2
G9-582 4-CF3Ph (4-CF3OPh)CH2OCH2
G9-583 4-CF3Ph (2-CNPh)CH2OCH2
G9-584 4-CF3Ph (3-CNPh)CH2OCH2
G9-585 4-CF3Ph (4-CNPh)CH2OCH2
G9-586 4-CF3Ph (2-N02Ph)CH2OCH2
G9-587 4-CF3Ph (3-N02Ph)CH2OCH2
G9-588 4-CF3Ph (4-N02Ph)CH2OCH2
G9-589 4-CF3Ph (2-CF3Ph)CH2OCH2
G9-590 4-CF3Ph (3-CF3Ph)CH2OCH2
G9-591 4-CF3Ph (4-CF3Ph)CH2OCH2
G9-592 4-CF3Ph CH3C(=0)OCH2
G9-593 4-CF3Ph CH3CH2C(=0)OCH2
G9-594 4-CF3Ph CH(CH3)2C(=0)OCH2
G9-595 4-CF3Ph (CH3)3C(=0)OCH2
G9-596 4-CF3Ph (CH3)3CCH2(=0)OCH2
G9-597 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G9-598 4-CF3Ph CF3C(=0)OCH2
G9-599 4-CF3Ph CF3CF2C(=0)OCH2
G9-600 4-CF3Ph (c-hex)C(=0)OCH2
G9-601 4-CF3Ph PhC(=0)OCH2
G9-602 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G9-603 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G9-604 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G9-605 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G9-606 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G9-607 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G9-608 4-CF3Ph (2-FPh)C(=0)OCH2
G9-609 4-CF3Ph (3-FPh)C(=0)OCH2
G9-610 4-CF3Ph (4-FPh)C(=0)OCH2
G9-611 4-CF3Ph (2-CIPh)C(=0)OCH2
G9-612 4-CF3Ph (3-CIPh)C(=0)OCH2
G9-613 4-CF3Ph (4-CIPh)C(=0)OCH2
G9-614 4-CF3Ph (2-BrPh)C(=0)OCH2
G9-615 4-CF3Ph (3-BrPh)C(=0)OCH2
G9-616 4-CF3Ph (4-BrPh)C(=0)OCH2
G9-617 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G9-618 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G9-619 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G9-620 4-CF3Ph (2-CNPh)C(=0)OCH2
G9-621 4-CF3Ph (3-CNPh)C(=0)OCH2
G9-622 4-CF3Ph (4-CNPh)C(=0)OCH2
G9-623 4-CF3Ph (2-N02Ph)C(=0)OCH2
G9-624 4-CF3Ph (3-N02Ph)C(=0)OCH2
G9-625 4-CF3Ph (4-N02Ph)C(=0)OCH2
G9-626 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G9-627 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G9-628 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G9-629 3,5-(CF3)2Ph CH3
G9-630 3,5-(CF3)2Ph CH3CH2
G9-674 3,5-(CF3)2Ph (4-FPh)OCH2
G9-675 3,5-(CF3)2Ph (2-CIPh)OCH2
G9-676 3,5-(CF3)2Ph (3-CIPh)OCH2
G9-677 3,5-(CF3)2Ph (4-CIPh)OCH2
G9-678 3,5-(CF3)2Ph (2-BrPh)OCH2
G9-679 3,5-(CF3)2Ph (3-BrPh)OCH2
G9-680 3,5-(CF3)2Ph (4-BrPh)OCH2
G9-681 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G9-682 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G9-683 3,5-(CF3)2Ph (4-CF3OPh)OCH2
G9-684 3,5-(CF3)2Ph (2-CNPh)OCH2
G9-685 3,5-(CF3)2Ph (3-CNPh)OCH2
G9-686 3,5-(CF3)2Ph (4-CNPh)OCH2
G9-687 3,5-(CF3)2Ph (2-N02Ph)OCH2
G9-688 3,5-(CF3)2Ph (3-N02Ph)OCH2
G9-689 3,5-(CF3)2Ph (4-N02Ph)OCH2
G9-690 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G9-691 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G9-692 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G9-693 3,5-(CF3)2Ph PhCH2OCH2
G9-694 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G9-695 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G9-696 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G9-697 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G9-698 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G9-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G9-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G9-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G9-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G9-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G9-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G9-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G9-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G9-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G9-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G9-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G9-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G9-711 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G9-712 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G9-713 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G9-714 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G9-715 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G9-716 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G9-717 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G9-718 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G9-719 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G9-720 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G9-721 3,5-(CF3)2Ph CH3C(=0)OCH2
G9-722 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G9-723 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G9-724 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G9-725 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G9-726 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G9-727 3,5-(CF3)2Ph CF3C(=0)OCH2
G9-728 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G9-729 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G9-730 3,5-(CF3)2Ph PhC(=0)OCH2
G9-731 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G9-732 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G9-733 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G9-734 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G9-735 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G9-736 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G9-737 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G9-738 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G9-739 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G9-740 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G9-741 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G9-742 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G9-743 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G9-744 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G9-745 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G9-746 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G9-747 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G9-748 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G9-749 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G9-750 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G9-751 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G9-752 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G9-753 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G9-754 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G9-755 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G9-756 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G9-757 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0303] Table 9a
G13-185 CF3 (3-FPh)CH2OCH2
G13-186 CF3 (4-FPh)CH2OCH2
G13-187 CF3 (2-CIPh)CH2OCH2
G13-188 CF3 (3-CIPh)CH2OCH2
G13-189 CF3 (4-CIPh)CH2OCH2
G13-190 CF3 (2-BrPh)CH2OCH2
G13-191 CF3 (3-BrPh)CH2OCH2
G13-192 CF3 (4-BrPh)CH2OCH2
G13-193 CF3 (2-CF3OPh)CH2OCH2
G13-194 CF3 (3-CF3OPh)CH2OCH2
G13-195 CF3 (4-CF3OPh)CH2OCH2
G13-196 CF3 (2-CNPh)CH2OCH2
G13-197 CF3 (3-CNPh)CH2OCH2
G13-198 CF3 (4-CNPh)CH2OCH2
G13-199 CF3 (2-N02Ph)CH2OCH2
G 13-200 CF3 (3-N02Ph)CH2OCH2
G13-201 CF3 (4-N02Ph)CH2OCH2
G 13-202 CF3 (2-CF3Ph)CH2OCH2
G 13-203 CF3 (3-CF3Ph)CH2OCH2
G 13-204 CF3 (4-CF3Ph)CH2OCH2
G 13-205 CF3 CH3C(=0)OCH2
G 13-206 CF3 CH3CH2C(=0)OCH2
G 13-207 CF3 CH(CH3)2C(=0)OCH2
G 13-208 CF3 (CH3)3C(=0)OCH2
G 13-209 CF3 (CH3)3CCH2(=0)OCH2
G13-210 CF3 CH3CH2C(CH3)2C(=0)OCH2
G13-211 CF3 CF3C(=0)OCH2
G13-212 CF3 CF3CF2C(=0)OCH2
G13-213 CF3 (c-hex)C(=0)OCH2
G13-214 CF3 PhC(=0)OCH2
G13-215 CF3 (2-CH3Ph)C(=0)OCH2
G13-216 CF3 (3-CH3Ph)C(=0)OCH2
G13-217 CF3 (4-CH3Ph)C(=0)OCH2
G13-218 CF3 (2-CH3OPh)C(=0)OCH2
G13-219 CF3 (3-CH3OPh)C(=0)OCH2
G 13-220 CF3 (4-CH3OPh)C(=0)OCH2
G 13-221 CF3 (2-FPh)C(=0)OCH2
G 13-222 CF3 (3-FPh)C(=0)OCH2
G 13-223 CF3 (4-FPh)C(=0)OCH2
G 13-224 CF3 (2-CIPh)C(=0)OCH2
G 13-225 CF3 (3-CIPh)C(=0)OCH2
G 13-226 CF3 (4-CIPh)C(=0)OCH2
G 13-227 CF3 (2-BrPh)C(=0)OCH2
G 13-228 CF3 (3-BrPh)C(=0)OCH2
G 13-229 CF3 (4-BrPh)C(=0)OCH2
G 13-230 CF3 (2-CF3OPh)C(=0)OCH2
G13-231 CF3 (3-CF3OPh)C(=0)OCH2
G 13-275 2-CF3Ph (CH3)3CCH20CH2
G 13-276 2-CF3Ph CH3CH2C(CH3)2OCH2
G 13-277 2-CF3Ph (c-hex)OCH2
G 13-278 2-CF3Ph PhOCH2
G 13-279 2-CF3Ph (2-CH3Ph)OCH2
G 13-280 2-CF3Ph (3-CH3Ph)OCH2
G13-281 2-CF3Ph (4-CH3Ph)OCH2
G 13-282 2-CF3Ph (2-CH3OPh)OCH2
G 13-283 2-CF3Ph (3-CH3OPh)OCH2
G 13-284 2-CF3Ph (4-CH3OPh)OCH2
G 13-285 2-CF3Ph (2-FPh)OCH2
G 13-286 2-CF3Ph (3-FPh)OCH2
G 13-287 2-CF3Ph (4-FPh)OCH2
G 13-288 2-CF3Ph (2-CIPh)OCH2
G 13-289 2-CF3Ph (3-CIPh)OCH2
G 13-290 2-CF3Ph (4-CIPh)OCH2
G13-291 2-CF3Ph (2-BrPh)OCH2
G 13-292 2-CF3Ph (3-BrPh)OCH2
G 13-293 2-CF3Ph (4-BrPh)OCH2
G 13-294 2-CF3Ph (2-CF3OPh)OCH2
G 13-295 2-CF3Ph (3-CF3OPh)OCH2
G 13-296 2-CF3Ph (4-CF3OPh)OCH2
G 13-297 2-CF3Ph (2-CNPh)OCH2
G 13-298 2-CF3Ph (3-CNPh)OCH2
G 13-299 2-CF3Ph (4-CNPh)OCH2
G13-300 2-CF3Ph (2-N02Ph)OCH2
G13-301 2-CF3Ph (3-N02Ph)OCH2
G 13-302 2-CF3Ph (4-N02Ph)OCH2
G13-303 2-CF3Ph (2-CF3Ph)OCH2
G 13-304 2-CF3Ph (3-CF3Ph)OCH2
G13-305 2-CF3Ph (4-CF3Ph)OCH2
G 13-306 2-CF3Ph PhCH2OCH2
G13-307 2-CF3Ph (2-CH3Ph)CH2OCH2
G13-308 2-CF3Ph (3-CH3Ph)CH2OCH2
G13-309 2-CF3Ph (4-CH3Ph)CH2OCH2
G13-310 2-CF3Ph (2-CH3OPh)CH2OCH2
G13-311 2-CF3Ph (3-CH3OPh)CH2OCH2
G13-312 2-CF3Ph (4-CH3OPh)CH2OCH2
G13-313 2-CF3Ph (2-FPh)CH2OCH2
G13-314 2-CF3Ph (3-FPh)CH2OCH2
G13-315 2-CF3Ph (4-FPh)CH2OCH2
G13-316 2-CF3Ph (2-CIPh)CH2OCH2
G13-317 2-CF3Ph (3-CIPh)CH2OCH2
G13-318 2-CF3Ph (4-CIPh)CH2OCH2
G13-319 2-CF3Ph (2-BrPh)CH2OCH2
G 13-320 2-CF3Ph (3-BrPh)CH2OCH2
G13-321 2-CF3Ph (4-BrPh)CH2OCH2
G 13-322 2-CF3Ph (2-CF3OPh)CH2OCH2
G 13-323 2-CF3Ph (3-CF3OPh)CH2OCH2
G 13-324 2-CF3Ph (4-CF3OPh)CH2OCH2
G 13-325 2-CF3Ph (2-CNPh)CH2OCH2
G 13-326 2-CF3Ph (3-CNPh)CH2OCH2
G 13-327 2-CF3Ph (4-CNPh)CH2OCH2
G 13-328 2-CF3Ph (2-N02Ph)CH2OCH2
G 13-329 2-CF3Ph (3-N02Ph)CH2OCH2
G13-330 2-CF3Ph (4-N02Ph)CH2OCH2
G13-331 2-CF3Ph (2-CF3Ph)CH2OCH2
G 13-332 2-CF3Ph (3-CF3Ph)CH2OCH2
G13-333 2-CF3Ph (4-CF3Ph)CH2OCH2
G 13-334 2-CF3Ph CH3C(=0)OCH2
G13-335 2-CF3Ph CH3CH2C(=0)OCH2
G 13-336 2-CF3Ph CH(CH3)2C(=0)OCH2
G13-337 2-CF3Ph (CH3)3C(=0)OCH2
G13-338 2-CF3Ph (CH3)3CCH2(=0)OCH2
G13-339 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 13-340 2-CF3Ph CF3C(=0)OCH2
G13-341 2-CF3Ph CF3CF2C(=0)OCH2
G 13-342 2-CF3Ph (c-hex)C(=0)OCH2
G 13-343 2-CF3Ph PhC(=0)OCH2
G 13-344 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G 13-345 2-CF3Ph (3-CH3Ph)C(=0)OCH2
G 13-346 2-CF3Ph (4-CH3Ph)C(=0)OCH2
G 13-347 2-CF3Ph (2-CH3OPh)C(=0)OCH2
G 13-348 2-CF3Ph (3-CH3OPh)C(=0)OCH2
G 13-349 2-CF3Ph (4-CH3OPh)C(=0)OCH2
G13-350 2-CF3Ph (2-FPh)C(=0)OCH2
G13-351 2-CF3Ph (3-FPh)C(=0)OCH2
G 13-352 2-CF3Ph (4-FPh)C(=0)OCH2
G13-353 2-CF3Ph (2-CIPh)C(=0)OCH2
G 13-354 2-CF3Ph (3-CIPh)C(=0)OCH2
G13-355 2-CF3Ph (4-CIPh)C(=0)OCH2
G 13-356 2-CF3Ph (2-BrPh)C(=0)OCH2
G13-357 2-CF3Ph (3-BrPh)C(=0)OCH2
G13-358 2-CF3Ph (4-BrPh)C(=0)OCH2
G13-359 2-CF3Ph (2-CF3OPh)C(=0)OCH2
G 13-360 2-CF3Ph (3-CF3OPh)C(=0)OCH2
G13-361 2-CF3Ph (4-CF3OPh)C(=0)OCH2
G 13-362 2-CF3Ph (2-CNPh)C(=0)OCH2
G 13-363 2-CF3Ph (3-CNPh)C(=0)OCH2
G 13-364 2-CF3Ph (4-CNPh)C(=0)OCH2
G 13-365 2-CF3Ph (2-N02Ph)C(=0)OCH2
G 13-366 2-CF3Ph (3-N02Ph)C(=0)OCH2
G 13-367 2-CF3Ph (4-N02Ph)C(=0)OCH2
G 13-368 2-CF3Ph (2-CF3Ph)C(=0)OCH2
G13-413 3-CF3Ph (4-CH3OPh)OCH2
G13-414 3-CF3Ph (2-FPh)OCH2
G13-415 3-CF3Ph (3-FPh)OCH2
G13-416 3-CF3Ph (4-FPh)OCH2
G13-417 3-CF3Ph (2-CIPh)OCH2
G13-418 3-CF3Ph (3-CIPh)OCH2
G13-419 3-CF3Ph (4-CIPh)OCH2
G 13-420 3-CF3Ph (2-BrPh)OCH2
G 13-421 3-CF3Ph (3-BrPh)OCH2
G 13-422 3-CF3Ph (4-BrPh)OCH2
G 13-423 3-CF3Ph (2-CF3OPh)OCH2
G 13-424 3-CF3Ph (3-CF3OPh)OCH2
G 13-425 3-CF3Ph (4-CF3OPh)OCH2
G 13-426 3-CF3Ph (2-CNPh)OCH2
G 13-427 3-CF3Ph (3-CNPh)OCH2
G 13-428 3-CF3Ph (4-CNPh)OCH2
G 13-429 3-CF3Ph (2-N02Ph)OCH2
G 13-430 3-CF3Ph (3-N02Ph)OCH2
G13-431 3-CF3Ph (4-N02Ph)OCH2
G 13-432 3-CF3Ph (2-CF3Ph)OCH2
G 13-433 3-CF3Ph (3-CF3Ph)OCH2
G 13-434 3-CF3Ph (4-CF3Ph)OCH2
G 13-435 3-CF3Ph PhCH2OCH2
G 13-436 3-CF3Ph (2-CH3Ph)CH2OCH2
G 13-437 3-CF3Ph (3-CH3Ph)CH2OCH2
G 13-438 3-CF3Ph (4-CH3Ph)CH2OCH2
G 13-439 3-CF3Ph (2-CH3OPh)CH2OCH2
G 13-440 3-CF3Ph (3-CH3OPh)CH2OCH2
G 13-441 3-CF3Ph (4-CH3OPh)CH2OCH2
G 13-442 3-CF3Ph (2-FPh)CH2OCH2
G 13-443 3-CF3Ph (3-FPh)CH2OCH2
G 13-444 3-CF3Ph (4-FPh)CH2OCH2
G 13-445 3-CF3Ph (2-CIPh)CH2OCH2
G 13-446 3-CF3Ph (3-CIPh)CH2OCH2
G 13-447 3-CF3Ph (4-CIPh)CH2OCH2
G 13-448 3-CF3Ph (2-BrPh)CH2OCH2
G 13-449 3-CF3Ph (3-BrPh)CH2OCH2
G 13-450 3-CF3Ph (4-BrPh)CH2OCH2
G13-451 3-CF3Ph (2-CF3OPh)CH2OCH2
G 13-452 3-CF3Ph (3-CF3OPh)CH2OCH2
G 13-453 3-CF3Ph (4-CF3OPh)CH2OCH2
G 13-454 3-CF3Ph (2-CNPh)CH2OCH2
G 13-455 3-CF3Ph (3-CNPh)CH2OCH2
G 13-456 3-CF3Ph (4-CNPh)CH2OCH2
G 13-457 3-CF3Ph (2-N02Ph)CH2OCH2
G 13-458 3-CF3Ph (3-N02Ph)CH2OCH2
G13-551 4-CF3Ph (4-BrPh)OCH2
G 13-552 4-CF3Ph (2-CF3OPh)OCH2
G13-553 4-CF3Ph (3-CF3OPh)OCH2
G 13-554 4-CF3Ph (4-CF3OPh)OCH2
G13-555 4-CF3Ph (2-CNPh)OCH2
G 13-556 4-CF3Ph (3-CNPh)OCH2
G13-557 4-CF3Ph (4-CNPh)OCH2
G13-558 4-CF3Ph (2-N02Ph)OCH2
G13-559 4-CF3Ph (3-N02Ph)OCH2
G 13-560 4-CF3Ph (4-N02Ph)OCH2
G13-561 4-CF3Ph (2-CF3Ph)OCH2
G 13-562 4-CF3Ph (3-CF3Ph)OCH2
G 13-563 4-CF3Ph (4-CF3Ph)OCH2
G 13-564 4-CF3Ph PhCH2OCH2
G 13-565 4-CF3Ph (2-CH3Ph)CH2OCH2
G 13-566 4-CF3Ph (3-CH3Ph)CH2OCH2
G 13-567 4-CF3Ph (4-CH3Ph)CH2OCH2
G 13-568 4-CF3Ph (2-CH3OPh)CH2OCH2
G 13-569 4-CF3Ph (3-CH3OPh)CH2OCH2
G13-570 4-CF3Ph (4-CH3OPh)CH2OCH2
G13-571 4-CF3Ph (2-FPh)CH2OCH2
G 13-572 4-CF3Ph (3-FPh)CH2OCH2
G13-573 4-CF3Ph (4-FPh)CH2OCH2
G 13-574 4-CF3Ph (2-CIPh)CH2OCH2
G13-575 4-CF3Ph (3-CIPh)CH2OCH2
G 13-576 4-CF3Ph (4-CIPh)CH2OCH2
G13-577 4-CF3Ph (2-BrPh)CH2OCH2
G13-578 4-CF3Ph (3-BrPh)CH2OCH2
G13-579 4-CF3Ph (4-BrPh)CH2OCH2
G13-580 4-CF3Ph (2-CF3OPh)CH2OCH2
G13-581 4-CF3Ph (3-CF3OPh)CH2OCH2
G 13-582 4-CF3Ph (4-CF3OPh)CH2OCH2
G13-583 4-CF3Ph (2-CNPh)CH2OCH2
G 13-584 4-CF3Ph (3-CNPh)CH2OCH2
G13-585 4-CF3Ph (4-CNPh)CH2OCH2
G 13-586 4-CF3Ph (2-N02Ph)CH2OCH2
G13-587 4-CF3Ph (3-N02Ph)CH2OCH2
G13-588 4-CF3Ph (4-N02Ph)CH2OCH2
G13-589 4-CF3Ph (2-CF3Ph)CH2OCH2
G13-590 4-CF3Ph (3-CF3Ph)CH2OCH2
G13-591 4-CF3Ph (4-CF3Ph)CH2OCH2
G 13-592 4-CF3Ph CH3C(=0)OCH2
G13-593 4-CF3Ph CH3CH2C(=0)OCH2
G 13-594 4-CF3Ph CH(CH3)2C(=0)OCH2
G13-595 4-CF3Ph (CH3)3C(=0)OCH2
G 13-596 4-CF3Ph (CH3)3CCH2(=0)OCH2
G13-597 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G13-598 4-CF3Ph CF3C(=0)OCH2
G13-599 4-CF3Ph CF3CF2C(=0)OCH2
G 13-600 4-CF3Ph (c-hex)C(=0)OCH2
G13-601 4-CF3Ph PhC(=0)OCH2
G 13-602 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G 13-603 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G 13-604 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G 13-605 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G 13-606 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G 13-607 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G 13-608 4-CF3Ph (2-FPh)C(=0)OCH2
G 13-609 4-CF3Ph (3-FPh)C(=0)OCH2
G13-610 4-CF3Ph (4-FPh)C(=0)OCH2
G13-611 4-CF3Ph (2-CIPh)C(=0)OCH2
G13-612 4-CF3Ph (3-CIPh)C(=0)OCH2
G13-613 4-CF3Ph (4-CIPh)C(=0)OCH2
G13-614 4-CF3Ph (2-BrPh)C(=0)OCH2
G13-615 4-CF3Ph (3-BrPh)C(=0)OCH2
G13-616 4-CF3Ph (4-BrPh)C(=0)OCH2
G13-617 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G13-618 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G13-619 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G 13-620 4-CF3Ph (2-CNPh)C(=0)OCH2
G 13-621 4-CF3Ph (3-CNPh)C(=0)OCH2
G 13-622 4-CF3Ph (4-CNPh)C(=0)OCH2
G 13-623 4-CF3Ph (2-N02Ph)C(=0)OCH2
G 13-624 4-CF3Ph (3-N02Ph)C(=0)OCH2
G 13-625 4-CF3Ph (4-N02Ph)C(=0)OCH2
G 13-626 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G 13-627 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G 13-628 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G 13-629 3,5-(CF3)2Ph CH3
G 13-630 3,5-(CF3)2Ph CH3CH2
G13-631 3,5-(CF3)2Ph CH3CH2CH2
G 13-632 3,5-(CF3)2Ph (CH3)2CH
G 13-633 3,5-(CF3)2Ph CH3C(=0)
G 13-634 3,5-(CF3)2Ph CH3CH2C(=0)
G 13-635 3,5-(CF3)2Ph (CH3)2CHC(=0)
G 13-636 3,5-(CF3)2Ph (CH3)3CC(=0)
G 13-637 3,5-(CF3)2Ph (CH3)3CCH2C(=0)
G 13-638 3,5-(CF3)2Ph CH3CH2CH(CH3)C(=0)
G 13-639 3,5-(CF3)2Ph (CH3)2CHCH2C(=0)
G 13-640 3,5-(CF3)2Ph (CH3)3CCH2CH2C(=0)
G 13-641 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)
G 13-642 3,5-(CF3)2Ph (c-hex)C(=0)
G 13-643 3,5-(CF3)2Ph (c-pen)C(=0)
G 13-644 3,5-(CF3)2Ph (c-hep)C(=0)
G 13-645 3,5-(CF3)2Ph (c-pro)C(=0)
G 13-689 3,5-(CF3)2Ph (4-N02Ph)OCH2
G 13-690 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G13-691 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G 13-692 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G 13-693 3,5-(CF3)2Ph PhCH2OCH2
G 13-694 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G 13-695 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G 13-696 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G 13-697 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G 13-698 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G 13-699 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G13-700 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G13-701 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G 13-702 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G13-703 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G 13-704 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G13-705 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G 13-706 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G13-707 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G13-708 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G13-709 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G13-710 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G13-711 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G13-712 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G13-713 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G13-714 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G13-715 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G13-716 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G13-717 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G13-718 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G13-719 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G 13-720 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G13-721 3,5-(CF3)2Ph CH3C(=0)OCH2
G 13-722 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G 13-723 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G 13-724 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G 13-725 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G 13-726 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G 13-727 3,5-(CF3)2Ph CF3C(=0)OCH2
G 13-728 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G 13-729 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G13-730 3,5-(CF3)2Ph PhC(=0)OCH2
G13-731 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G 13-732 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G13-733 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G 13-734 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G13-735 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G 13-736 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G13-737 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G13-738 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G13-739 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G 13-740 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G13-741 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G 13-742 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G 13-743 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G 13-744 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G 13-745 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G 13-746 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G 13-747 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G 13-748 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G 13-749 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G13-750 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G13-751 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G 13-752 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G13-753 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G 13-754 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G13-755 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G 13-756 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G13-757 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0304] Table 9b
G 14-62 2-CF3Ph H CH3
G 14-63 3-CF3Ph H CH3
G 14-64 4-CF3Ph H CH3
G 14-65 2-CF3CF2Ph H CH3
G 14-66 3-CF3CF2Ph H CH3
G 14-67 4-CF3CF2Ph H CH3
G 14-68 2-CF3OPh H CH3
G 14-69 3-CF3OPh H CH3
G14-70 4-CF3OPh H CH3
G14-71 2-CF3CH2OPh H CH3
G 14-72 3-CF3CH2OPh H CH3
G14-73 4-CF3CH2OPh H CH3
G 14-74 2-CF3-3-F-Ph H CH3
G14-75 2-CF3-4-F-Ph H CH3
G 14-76 2-CF3-5-F-Ph H CH3
G14-77 2-CF3-6-F-Ph H CH3
G14-78 2-CF3-3-CI-Ph H CH3
G14-79 2-CF3-4-CI-Ph H CH3
G14-80 2-CF3-5-CI-Ph H CH3
G14-81 2-CF3-6-CI-Ph H CH3
G 14-82 2-CF3-3-CH3-Ph H CH3
G14-83 2-CF3-4-CH3-Ph H CH3
G 14-84 2-CF3-5-CH3-Ph H CH3
G14-85 2-CF3-6-CH3-Ph H CH3
G 14-86 2,3-(CF3)2Ph H CH3
G14-87 2,4-(CF3)2Ph H CH3
G14-88 2,6-(CF3)2Ph H CH3
G14-89 3,5-(CF3)2Ph H CH3
G14-90 2-CF3-3-CN-Ph H CH3
G14-91 2-CF3-4-CNPh H CH3
G 14-92 2-CF3-5-CN-Ph H CH3
G14-93 2-CF3-6-CN-Ph H CH3
G 14-94 2-Pyridyl H CH3
G14-95 3-Pyridyl H CH3
G 14-96 4-Pyridyl H CH3
G14-97 CF3 H Ph
G14-98 CF3 H 2-F-Ph
G14-99 CF3 H 3-F-Ph
G14-100 CF3 H 4-F-Ph
G14-101 CF3 H 2-CI-Ph
G14-102 CF3 H 3-CI-Ph
G14-103 CF3 H 4-CI-Ph
G14-104 CF3 H 2-CF3-Ph
G14-105 CF3 H 3-CF3-Ph
G14-106 CF3 H 4-CF3-Ph
G14-107 CF3 H 2-CF3Q-Ph
G14-151 CF3 (3-CH3OPh)OCH2 2-CI-Ph
G14-152 CF3 (4-CH3OPh)OCH2 2-CI-Ph
G14-153 CF3 (2-FPh)OCH2 2-CI-Ph
G14-154 CF3 (3-FPh)OCH2 2-CI-Ph
G14-155 CF3 (4-FPh)OCH2 2-CI-Ph
G14-156 CF3 (2-CIPh)OCH2 2-CI-Ph
G14-157 CF3 (3-CIPh)OCH2 2-CI-Ph
G14-158 CF3 (4-CIPh)OCH2 2-CI-Ph
G14-159 CF3 (2-BrPh)OCH2 2-CI-Ph
G14-160 CF3 (3-BrPh)OCH2 2-CI-Ph
G14-161 CF3 (4-BrPh)OCH2 2-CI-Ph
G14-162 CF3 (2-CF3OPh)OCH2 2-CI-Ph
G14-163 CF3 (3-CF3OPh)OCH2 2-CI-Ph
G14-164 CF3 (4-CF3OPh)OCH2 2-CI-Ph
G14-165 CF3 (2-CNPh)OCH2 2-CI-Ph
G14-166 CF3 (3-CNPh)OCH2 2-CI-Ph
G14-167 CF3 (4-CNPh)OCH2 2-CI-Ph
G14-168 CF3 (2-N02Ph)OCH2 2-CI-Ph
G14-169 CF3 (3-N02Ph)OCH2 2-CI-Ph
G14-170 CF3 (4-N02Ph)OCH2 2-CI-Ph
G14-171 CF3 (2-CF3Ph)OCH2 2-CI-Ph
G14-172 CF3 (3-CF3Ph)OCH2 2-CI-Ph
G14-173 CF3 (4-CF3Ph)OCH2 2-CI-Ph
G14-174 CF3 PhCH2OCH2 2-CI-Ph
G14-175 CF3 (2-CH3Ph)CH2OCH2 2-CI-Ph
G14-176 CF3 (3-CH3Ph)CH2OCH2 2-CI-Ph
G14-177 CF3 (4-CH3Ph)CH2OCH2 2-CI-Ph
G14-178 CF3 (2-CH3OPh)CH2OCH2 2-CI-Ph
G14-179 CF3 (3-CH3OPh)CH2OCH2 2-CI-Ph
G14-180 CF3 (4-CH3OPh)CH2OCH2 2-CI-Ph
G14-181 CF3 (2-FPh)CH2OCH2 2-CI-Ph
G14-182 CF3 (3-FPh)CH2OCH2 2-CI-Ph
G14-183 CF3 (4-FPh)CH2OCH2 2-CI-Ph
G14-184 CF3 (2-CIPh)CH2OCH2 2-CI-Ph
G14-185 CF3 (3-CIPh)CH2OCH2 2-CI-Ph
G14-186 CF3 (4-CIPh)CH2OCH2 2-CI-Ph
G14-187 CF3 (2-BrPh)CH2OCH2 2-CI-Ph
G14-188 CF3 (3-BrPh)CH2OCH2 2-CI-Ph
G14-189 CF3 (4-BrPh)CH2OCH2 2-CI-Ph
G14-190 CF3 (2-CF3OPh)CH2OCH2 2-CI-Ph
G14-191 CF3 (3-CF3OPh)CH2OCH2 2-CI-Ph
G14-192 CF3 (4-CF3OPh)CH2OCH2 2-CI-Ph
G14-193 CF3 (2-CNPh)CH2OCH2 2-CI-Ph
G14-194 CF3 (3-CNPh)CH2OCH2 2-CI-Ph
G14-195 CF3 (4-CNPh)CH2OCH2 2-CI-Ph
G14-196 CF3 (2-N02Ph)CH2OCH2 2-CI-Ph
G14-197 CF3 (3-N02Ph)CH2OCH2 2-CI-Ph
G14-198 CF3 (4-N02Ph)CH2OCH2 2-CI-Ph
G14-199 CF3 (2-CF3Ph)CH2OCH2 2-CI-Ph
G 14-200 CF3 (3-CF3Ph)CH2OCH2 2-CI-Ph
G14-201 CF3 (4-CF3Ph)CH2OCH2 2-CI-Ph
G 14-202 CF3 CH3C(=0)OCH2 2-CI-Ph
G 14-203 CF3 CH3CH2C(=0)OCH2 2-CI-Ph
G 14-204 CF3 CH(CH3)2C(=0)OCH2 2-CI-Ph
G 14-205 CF3 (CH3)3C(=0)OCH2 2-CI-Ph
G 14-206 CF3 (CH3)3CCH2(=0)OCH2 2-CI-Ph
G 14-207 CF3 CH3CH2C(CH3)2C(=0)OCH2 2-CI-Ph
G 14-208 CF3 CF3C(=0)OCH2 2-CI-Ph
G 14-209 CF3 CF3CF2C(=0)OCH2 2-CI-Ph
G14-210 CF3 (c-hex)C(=0)OCH2 2-CI-Ph
G14-211 CF3 PhC(=0)OCH2 2-CI-Ph
G14-212 CF3 (2-CH3Ph)C(=0)OCH2 2-CI-Ph
G14-213 CF3 (3-CH3Ph)C(=0)OCH2 2-CI-Ph
G14-214 CF3 (4-CH3Ph)C(=0)OCH2 2-CI-Ph
G14-215 CF3 (2-CH3OPh)C(=0)OCH2 2-CI-Ph
G14-216 CF3 (3-CH3OPh)C(=0)OCH2 2-CI-Ph
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G14-793 CF3 (3-CH3Ph)OCH2 4-CF3-Ph
G 14-794 CF3 (4-CH3Ph)OCH2 4-CF3-Ph
G14-795 CF3 (2-CH3OPh)OCH2 4-CF3-Ph
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G14-797 CF3 (4-CH3OPh)OCH2 4-CF3-Ph
G14-798 CF3 (2-FPh)OCH2 4-CF3-Ph
G14-799 CF3 (3-FPh)OCH2 4-CF3-Ph
G14-800 CF3 (4-FPh)OCH2 4-CF3-Ph
G14-801 CF3 (2-CIPh)OCH2 4-CF3-Ph
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G14-803 CF3 (4-CIPh)OCH2 4-CF3-Ph
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G14-805 CF3 (3-BrPh)OCH2 4-CF3-Ph
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G14-807 CF3 (2-CF3OPh)OCH2 4-CF3-Ph
G14-808 CF3 (3-CF3OPh)OCH2 4-CF3-Ph
G14-809 CF3 (4-CF3OPh)OCH2 4-CF3-Ph
G14-810 CF3 (2-CNPh)OCH2 4-CF3-Ph
G14-811 CF3 (3-CNPh)OCH2 4-CF3-Ph
G14-812 CF3 (4-CNPh)OCH2 4-CF3-Ph
G14-813 CF3 (2-N02Ph)OCH2 4-CF3-Ph
G14-814 CF3 (3-N02Ph)OCH2 4-CF3-Ph
G14-815 CF3 (4-N02Ph)OCH2 4-CF3-Ph
G14-816 CF3 (2-CF3Ph)OCH2 4-CF3-Ph
G14-817 CF3 (3-CF3Ph)OCH2 4-CF3-Ph
G14-818 CF3 (4-CF3Ph)OCH2 4-CF3-Ph
G14-819 CF3 PhCH2OCH2 4-CF3-Ph
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G14-821 CF3 (3-CH3Ph)CH2OCH2 4-CF3-Ph
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G14-830 CF3 (3-CIPh)CH2OCH2 4-CF3-Ph
G14-831 CF3 (4-CIPh)CH2OCH2 4-CF3-Ph
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G14-833 CF3 (3-BrPh)CH2OCH2 4-CF3-Ph
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G14-835 CF3 (2-CF3OPh)CH2OCH2 4-CF3-Ph
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G14-837 CF3 (4-CF3OPh)CH2OCH2 4-CF3-Ph
G14-838 CF3 (2-CNPh)CH2OCH2 4-CF3-Ph
G14-839 CF3 (3-CNPh)CH2OCH2 4-CF3-Ph
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G14-850 CF3 (CH3)3C(=0)OCH2 4-CF3-Ph
G14-851 CF3 (CH3)3CCH2(=0)OCH2 4-CF3-Ph
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G14-857 CF3 (2-CH3Ph)C(=0)OCH2 4-CF3-Ph
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G14-859 CF3 (4-CH3Ph)C(=0)OCH2 4-CF3-Ph
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G15-87 2,4-(CF3)2Ph H CH3
G15-88 2,6-(CF3)2Ph H CH3
G15-89 3,5-(CF3)2Ph H CH3
G15-90 2-CF3-3-CN-Ph H CH3
G15-91 2-CF3-4-CNPh H CH3
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G15-93 2-CF3-6-CN-Ph H CH3
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G15-95 3-Pyridyl H CH3
G 15-96 4-Pyridyl H CH3
G15-97 CF3 H Ph
G15-98 CF3 H 2-F-Ph
G15-99 CF3 H 3-F-Ph
G15-100 CF3 H 4-F-Ph
G15-101 CF3 H 2-CI-Ph
G15-102 CF3 H 3-CI-Ph
G15-103 CF3 H 4-CI-Ph
G15-104 CF3 H 2-CF3-Ph
G15-105 CF3 H 3-CF3-Ph
G15-106 CF3 H 4-CF3-Ph
G15-107 CF3 H 2-CF30-Ph
G15-108 CF3 H 3-CF30-Ph
G15-109 CF3 H 4-CF30-Ph
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G15-111 CF3 CH3CH2 2-CI-Ph
G15-112 CF3 CH3CH2CH2 2-CI-Ph
G15-113 CF3 (CH3)2CH 2-CI-Ph
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G15-117 CF3 (CH3)3CC(=0) 2-CI-Ph
G15-118 CF3 (CH3)3CCH2C(=0) 2-CI-Ph
G15-119 CF3 CH3CH2CH(CH3)C(=0) 2-CI-Ph
G15-120 CF3 (CH3)2CHCH2C(=0) 2-CI-Ph
G15-121 CF3 (CH3)3CCH2CH2C(=0) 2-CI-Ph
G15-122 CF3 CH3CH2C(CH3)2C(=0) 2-CI-Ph
G15-123 CF3 (c-hex)C(=0) 2-CI-Ph
G15-124 CF3 (c-pen)C(=0) 2-CI-Ph
G15-125 CF3 (c-hep)C(=0) 2-CI-Ph
G15-126 CF3 (c-pro)C(=0) 2-CI-Ph
G15-127 CF3 CF3C(=0) 2-CI-Ph
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G15-129 CF3 (CH3CH2)2NC(=0) 2-CI-Ph
G15-130 CF3 (CH3CH2CH2)2NC(=0) 2-CI-Ph
G15-131 CF3 CH3CH2N(CH3)C(=0) 2-CI-Ph
G15-132 CF3 [(CH3)2CHCH2]2NC(=0) 2-CI-Ph
G15-177 CF3 (4-CH3Ph)CH2OCH2 2-CI-Ph
G15-178 CF3 (2-CH3OPh)CH2OCH2 2-CI-Ph
G15-179 CF3 (3-CH3OPh)CH2OCH2 2-CI-Ph
G15-180 CF3 (4-CH3OPh)CH2OCH2 2-CI-Ph
G15-181 CF3 (2-FPh)CH2OCH2 2-CI-Ph
G15-182 CF3 (3-FPh)CH2OCH2 2-CI-Ph
G15-183 CF3 (4-FPh)CH2OCH2 2-CI-Ph
G15-184 CF3 (2-CIPh)CH2OCH2 2-CI-Ph
G15-185 CF3 (3-CIPh)CH2OCH2 2-CI-Ph
G15-186 CF3 (4-CIPh)CH2OCH2 2-CI-Ph
G15-187 CF3 (2-BrPh)CH2OCH2 2-CI-Ph
G15-188 CF3 (3-BrPh)CH2OCH2 2-CI-Ph
G15-189 CF3 (4-BrPh)CH2OCH2 2-CI-Ph
G15-190 CF3 (2-CF3OPh)CH2OCH2 2-CI-Ph
G15-191 CF3 (3-CF3OPh)CH2OCH2 2-CI-Ph
G15-192 CF3 (4-CF3OPh)CH2OCH2 2-CI-Ph
G15-193 CF3 (2-CNPh)CH2OCH2 2-CI-Ph
G15-194 CF3 (3-CNPh)CH2OCH2 2-CI-Ph
G15-195 CF3 (4-CNPh)CH2OCH2 2-CI-Ph
G15-196 CF3 (2-N02Ph)CH2OCH2 2-CI-Ph
G15-197 CF3 (3-N02Ph)CH2OCH2 2-CI-Ph
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G15-212 CF3 (2-CH3Ph)C(=0)OCH2 2-CI-Ph
G15-213 CF3 (3-CH3Ph)C(=0)OCH2 2-CI-Ph
G15-214 CF3 (4-CH3Ph)C(=0)OCH2 2-CI-Ph
G15-215 CF3 (2-CH3OPh)C(=0)OCH2 2-CI-Ph
G15-216 CF3 (3-CH3OPh)C(=0)OCH2 2-CI-Ph
G15-217 CF3 (4-CH3OPh)C(=0)OCH2 2-CI-Ph
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G 15-460 CF3 CH3C(=0)OCH2 4-CI-Ph
G 15-461 CF3 CH3CH2C(=0)OCH2 4-CI-Ph
G 15-462 CF3 CH(CH3)2C(=0)OCH2 4-CI-Ph
G 15-463 CF3 (CH3)3C(=0)OCH2 4-CI-Ph
G 15-464 CF3 (CH3)3CCH2(=0)OCH2 4-CI-Ph
G 15-465 CF3 CH3CH2C(CH3)2C(=0)OCH2 4-CI-Ph
G 15-466 CF3 CF3C(=0)OCH2 4-CI-Ph
G 15-467 CF3 CF3CF2C(=0)OCH2 4-CI-Ph
G 15-468 CF3 (c-hex)C(=0)OCH2 4-CI-Ph
G 15-469 CF3 PhC(=0)OCH2 4-CI-Ph
G 15-470 CF3 (2-CH3Ph)C(=0)OCH2 4-CI-Ph
G15-471 CF3 (3-CH3Ph)C(=0)OCH2 4-CI-Ph
G 15-472 CF3 (4-CH3Ph)C(=0)OCH2 4-CI-Ph
G 15-473 CF3 (2-CH3OPh)C(=0)OCH2 4-CI-Ph
G 15-474 CF3 (3-CH3OPh)C(=0)OCH2 4-CI-Ph
G 15-475 CF3 (4-CH3OPh)C(=0)OCH2 4-CI-Ph
G 15-476 CF3 (2-FPh)C(=0)OCH2 4-CI-Ph
G 15-477 CF3 (3-FPh)C(=0)OCH2 4-CI-Ph
G 15-478 CF3 (4-FPh)C(=0)OCH2 4-CI-Ph
G 15-479 CF3 (2-CIPh)C(=0)OCH2 4-CI-Ph
G 15-480 CF3 (3-CIPh)C(=0)OCH2 4-CI-Ph
G15-481 CF3 (4-CIPh)C(=0)OCH2 4-CI-Ph
G 15-482 CF3 (2-BrPh)C(=0)OCH2 4-CI-Ph
G 15-483 CF3 (3-BrPh)C(=0)OCH2 4-CI-Ph
G 15-484 CF3 (4-BrPh)C(=0)OCH2 4-CI-Ph
G 15-485 CF3 (2-CF3OPh)C(=0)OCH2 4-CI-Ph
G 15-486 CF3 (3-CF3OPh)C(=0)OCH2 4-CI-Ph
G 15-487 CF3 (4-CF3OPh)C(=0)OCH2 4-CI-Ph
G 15-488 CF3 (2-CNPh)C(=0)OCH2 4-CI-Ph
G 15-489 CF3 (3-CNPh)C(=0)OCH2 4-CI-Ph
G 15-490 CF3 (4-CNPh)C(=0)OCH2 4-CI-Ph
G15-491 CF3 (2-N02Ph)C(=0)OCH2 4-CI-Ph
G 15-492 CF3 (3-N02Ph)C(=0)OCH2 4-CI-Ph
G 15-493 CF3 (4-N02Ph)C(=0)OCH2 4-CI-Ph
G 15-494 CF3 (2-CF3Ph)C(=0)OCH2 4-CI-Ph
G 15-495 CF3 (3-CF3Ph)C(=0)OCH2 4-CI-Ph
G 15-496 CF3 (4-CF3Ph)C(=0)OCH2 4-CI-Ph
G 15-497 CF3 CH3 2-CF3-Ph
G 15-498 CF3 CH3CH2 2-CF3-Ph
G 15-542 CF3 (4-FPh)OCH2 2-CF3-Ph
G 15-543 CF3 (2-CIPh)OCH2 2-CF3-Ph
G 15-544 CF3 (3-CIPh)OCH2 2-CF3-Ph
G 15-545 CF3 (4-CIPh)OCH2 2-CF3-Ph
G 15-546 CF3 (2-BrPh)OCH2 2-CF3-Ph
G 15-547 CF3 (3-BrPh)OCH2 2-CF3-Ph
G 15-548 CF3 (4-BrPh)OCH2 2-CF3-Ph
G 15-549 CF3 (2-CF3OPh)OCH2 2-CF3-Ph
G15-550 CF3 (3-CF3OPh)OCH2 2-CF3-Ph
G15-551 CF3 (4-CF3OPh)OCH2 2-CF3-Ph
G 15-552 CF3 (2-CNPh)OCH2 2-CF3-Ph
G15-553 CF3 (3-CNPh)OCH2 2-CF3-Ph
G 15-554 CF3 (4-CNPh)OCH2 2-CF3-Ph
G15-555 CF3 (2-N02Ph)OCH2 2-CF3-Ph
G 15-556 CF3 (3-N02Ph)OCH2 2-CF3-Ph
G15-557 CF3 (4-N02Ph)OCH2 2-CF3-Ph
G15-558 CF3 (2-CF3Ph)OCH2 2-CF3-Ph
G15-559 CF3 (3-CF3Ph)OCH2 2-CF3-Ph
G 15-560 CF3 (4-CF3Ph)OCH2 2-CF3-Ph
G15-561 CF3 PhCH2OCH2 2-CF3-Ph
G 15-562 CF3 (2-CH3Ph)CH2OCH2 2-CF3-Ph
G 15-563 CF3 (3-CH3Ph)CH2OCH2 2-CF3-Ph
G 15-564 CF3 (4-CH3Ph)CH2OCH2 2-CF3-Ph
G 15-565 CF3 (2-CH3OPh)CH2OCH2 2-CF3-Ph
G 15-566 CF3 (3-CH3OPh)CH2OCH2 2-CF3-Ph
G 15-567 CF3 (4-CH3OPh)CH2OCH2 2-CF3-Ph
G 15-568 CF3 (2-FPh)CH2OCH2 2-CF3-Ph
G 15-569 CF3 (3-FPh)CH2OCH2 2-CF3-Ph
G15-570 CF3 (4-FPh)CH2OCH2 2-CF3-Ph
G15-571 CF3 (2-CIPh)CH2OCH2 2-CF3-Ph
G 15-572 CF3 (3-CIPh)CH2OCH2 2-CF3-Ph
G15-573 CF3 (4-CIPh)CH2OCH2 2-CF3-Ph
G 15-574 CF3 (2-BrPh)CH2OCH2 2-CF3-Ph
G15-575 CF3 (3-BrPh)CH2OCH2 2-CF3-Ph
G 15-576 CF3 (4-BrPh)CH2OCH2 2-CF3-Ph
G15-577 CF3 (2-CF3OPh)CH2OCH2 2-CF3-Ph
G15-578 CF3 (3-CF3OPh)CH2OCH2 2-CF3-Ph
G15-579 CF3 (4-CF3OPh)CH2OCH2 2-CF3-Ph
G15-580 CF3 (2-CNPh)CH2OCH2 2-CF3-Ph
G15-581 CF3 (3-CNPh)CH2OCH2 2-CF3-Ph
G 15-582 CF3 (4-CNPh)CH2OCH2 2-CF3-Ph
G15-583 CF3 (2-N02Ph)CH2OCH2 2-CF3-Ph
G 15-584 CF3 (3-N02Ph)CH2OCH2 2-CF3-Ph
G15-585 CF3 (4-N02Ph)CH2OCH2 2-CF3-Ph
G 15-586 CF3 (2-CF3Ph)CH2OCH2 2-CF3-Ph
G15-587 CF3 (3-CF3Ph)CH2OCH2 2-CF3-Ph
G15-588 CF3 (4-CF3Ph)CH2OCH2 2-CF3-Ph
G15-589 CF3 CH3C(=0)OCH2 2-CF3-Ph
G15-590 CF3 CH3CH2C(=0)OCH2 2-CF3-Ph
G15-591 CF3 CH(CH3)2C(=0)OCH2 2-CF3-Ph
G 15-592 CF3 (CH3)3C(=0)OCH2 2-CF3-Ph
G15-593 CF3 (CH3)3CCH2(=0)OCH2 2-CF3-Ph
G 15-594 CF3 CH3CH2C(CH3)2C(=0)OCH2 2-CF3-Ph
G15-595 CF3 CF3C(=0)OCH2 2-CF3-Ph
G 15-596 CF3 CF3CF2C(=0)OCH2 2-CF3-Ph
G15-597 CF3 (c-hex)C(=0)OCH2 2-CF3-Ph
G15-598 CF3 PhC(=0)OCH2 2-CF3-Ph
G15-599 CF3 (2-CH3Ph)C(=0)OCH2 2-CF3-Ph
G 15-600 CF3 (3-CH3Ph)C(=0)OCH2 2-CF3-Ph
G15-601 CF3 (4-CH3Ph)C(=0)OCH2 2-CF3-Ph
G 15-602 CF3 (2-CH3OPh)C(=0)OCH2 2-CF3-Ph
G 15-603 CF3 (3-CH3OPh)C(=0)OCH2 2-CF3-Ph
G 15-604 CF3 (4-CH3OPh)C(=0)OCH2 2-CF3-Ph
G 15-605 CF3 (2-FPh)C(=0)OCH2 2-CF3-Ph
G 15-606 CF3 (3-FPh)C(=0)OCH2 2-CF3-Ph
G 15-607 CF3 (4-FPh)C(=0)OCH2 2-CF3-Ph
G 15-608 CF3 (2-CIPh)C(=0)OCH2 2-CF3-Ph
G 15-609 CF3 (3-CIPh)C(=0)OCH2 2-CF3-Ph
G15-610 CF3 (4-CIPh)C(=0)OCH2 2-CF3-Ph
G15-611 CF3 (2-BrPh)C(=0)OCH2 2-CF3-Ph
G15-612 CF3 (3-BrPh)C(=0)OCH2 2-CF3-Ph
G15-613 CF3 (4-BrPh)C(=0)OCH2 2-CF3-Ph
G15-614 CF3 (2-CF3OPh)C(=0)OCH2 2-CF3-Ph
G15-615 CF3 (3-CF3OPh)C(=0)OCH2 2-CF3-Ph
G15-616 CF3 (4-CF3OPh)C(=0)OCH2 2-CF3-Ph
G15-617 CF3 (2-CNPh)C(=0)OCH2 2-CF3-Ph
G15-618 CF3 (3-CNPh)C(=0)OCH2 2-CF3-Ph
G15-619 CF3 (4-CNPh)C(=0)OCH2 2-CF3-Ph
G 15-620 CF3 (2-N02Ph)C(=0)OCH2 2-CF3-Ph
G 15-621 CF3 (3-N02Ph)C(=0)OCH2 2-CF3-Ph
G 15-622 CF3 (4-N02Ph)C(=0)OCH2 2-CF3-Ph
G 15-623 CF3 (2-CF3Ph)C(=0)OCH2 2-CF3-Ph
G 15-624 CF3 (3-CF3Ph)C(=0)OCH2 2-CF3-Ph
G 15-625 CF3 (4-CF3Ph)C(=0)OCH2 2-CF3-Ph
G 15-626 CF3 CH3 3-CF3-Ph
G 15-627 CF3 CH3CH2 3-CF3-Ph
G 15-628 CF3 CH3CH2CH2 3-CF3-Ph
G 15-629 CF3 (CH3)2CH 3-CF3-Ph
G 15-630 CF3 CH3C(=0) 3-CF3-Ph
G15-631 CF3 CH3CH2C(=0) 3-CF3-Ph
G 15-632 CF3 (CH3)2CHC(=0) 3-CF3-Ph
G 15-633 CF3 (CH3)3CC(=0) 3-CF3-Ph
G 15-634 CF3 (CH3)3CCH2C(=0) 3-CF3-Ph
G 15-635 CF3 CH3CH2CH(CH3)C(=0) 3-CF3-Ph
G 15-636 CF3 (CH3)2CHCH2C(=0) 3-CF3-Ph
G 15-680 CF3 (4-CF3OPh)OCH2 3-CF3-Ph
G15-681 CF3 (2-CNPh)OCH2 3-CF3-Ph
G 15-682 CF3 (3-CNPh)OCH2 3-CF3-Ph
G 15-683 CF3 (4-CNPh)OCH2 3-CF3-Ph
G 15-684 CF3 (2-N02Ph)OCH2 3-CF3-Ph
G 15-685 CF3 (3-N02Ph)OCH2 3-CF3-Ph
G 15-686 CF3 (4-N02Ph)OCH2 3-CF3-Ph
G 15-687 CF3 (2-CF3Ph)OCH2 3-CF3-Ph
G 15-688 CF3 (3-CF3Ph)OCH2 3-CF3-Ph
G 15-689 CF3 (4-CF3Ph)OCH2 3-CF3-Ph
G 15-690 CF3 PhCH2OCH2 3-CF3-Ph
G15-691 CF3 (2-CH3Ph)CH2OCH2 3-CF3-Ph
G 15-692 CF3 (3-CH3Ph)CH2OCH2 3-CF3-Ph
G 15-693 CF3 (4-CH3Ph)CH2OCH2 3-CF3-Ph
G 15-694 CF3 (2-CH3OPh)CH2OCH2 3-CF3-Ph
G 15-695 CF3 (3-CH3OPh)CH2OCH2 3-CF3-Ph
G 15-696 CF3 (4-CH3OPh)CH2OCH2 3-CF3-Ph
G 15-697 CF3 (2-FPh)CH2OCH2 3-CF3-Ph
G 15-698 CF3 (3-FPh)CH2OCH2 3-CF3-Ph
G 15-699 CF3 (4-FPh)CH2OCH2 3-CF3-Ph
G15-700 CF3 (2-CIPh)CH2OCH2 3-CF3-Ph
G15-701 CF3 (3-CIPh)CH2OCH2 3-CF3-Ph
G 15-702 CF3 (4-CIPh)CH2OCH2 3-CF3-Ph
G15-703 CF3 (2-BrPh)CH2OCH2 3-CF3-Ph
G 15-704 CF3 (3-BrPh)CH2OCH2 3-CF3-Ph
G15-705 CF3 (4-BrPh)CH2OCH2 3-CF3-Ph
G 15-706 CF3 (2-CF3OPh)CH2OCH2 3-CF3-Ph
G15-707 CF3 (3-CF3OPh)CH2OCH2 3-CF3-Ph
G15-708 CF3 (4-CF3OPh)CH2OCH2 3-CF3-Ph
G15-709 CF3 (2-CNPh)CH2OCH2 3-CF3-Ph
G15-710 CF3 (3-CNPh)CH2OCH2 3-CF3-Ph
G15-711 CF3 (4-CNPh)CH2OCH2 3-CF3-Ph
G15-712 CF3 (2-N02Ph)CH2OCH2 3-CF3-Ph
G15-713 CF3 (3-N02Ph)CH2OCH2 3-CF3-Ph
G15-714 CF3 (4-N02Ph)CH2OCH2 3-CF3-Ph
G15-715 CF3 (2-CF3Ph)CH2OCH2 3-CF3-Ph
G15-716 CF3 (3-CF3Ph)CH2OCH2 3-CF3-Ph
G15-717 CF3 (4-CF3Ph)CH2OCH2 3-CF3-Ph
G15-718 CF3 CH3C(=0)OCH2 3-CF3-Ph
G15-719 CF3 CH3CH2C(=0)OCH2 3-CF3-Ph
G 15-720 CF3 CH(CH3)2C(=0)OCH2 3-CF3-Ph
G15-721 CF3 (CH3)3C(=0)OCH2 3-CF3-Ph
G 15-722 CF3 (CH3)3CCH2(=0)OCH2 3-CF3-Ph
G 15-723 CF3 CH3CH2C(CH3)2C(=0)OCH2 3-CF3-Ph
G 15-724 CF3 CF3C(=0)OCH2 3-CF3-Ph
G 15-725 CF3 CF3CF2C(=0)OCH2 3-CF3-Ph
G 15-726 CF3 (c-hex)C(=0)OCH2 3-CF3-Ph
G 15-727 CF3 PhC(=0)OCH2 3-CF3-Ph
G 15-728 CF3 (2-CH3Ph)C(=0)OCH2 3-CF3-Ph
G 15-729 CF3 (3-CH3Ph)C(=0)OCH2 3-CF3-Ph
G15-730 CF3 (4-CH3Ph)C(=0)OCH2 3-CF3-Ph
G15-731 CF3 (2-CH3OPh)C(=0)OCH2 3-CF3-Ph
G 15-732 CF3 (3-CH3OPh)C(=0)OCH2 3-CF3-Ph
G15-733 CF3 (4-CH3OPh)C(=0)OCH2 3-CF3-Ph
G 15-734 CF3 (2-FPh)C(=0)OCH2 3-CF3-Ph
G15-735 CF3 (3-FPh)C(=0)OCH2 3-CF3-Ph
G 15-736 CF3 (4-FPh)C(=0)OCH2 3-CF3-Ph
G15-737 CF3 (2-CIPh)C(=0)OCH2 3-CF3-Ph
G15-738 CF3 (3-CIPh)C(=0)OCH2 3-CF3-Ph
G15-739 CF3 (4-CIPh)C(=0)OCH2 3-CF3-Ph
G 15-740 CF3 (2-BrPh)C(=0)OCH2 3-CF3-Ph
G15-741 CF3 (3-BrPh)C(=0)OCH2 3-CF3-Ph
G 15-742 CF3 (4-BrPh)C(=0)OCH2 3-CF3-Ph
G 15-743 CF3 (2-CF3OPh)C(=0)OCH2 3-CF3-Ph
G 15-744 CF3 (3-CF3OPh)C(=0)OCH2 3-CF3-Ph
G 15-745 CF3 (4-CF3OPh)C(=0)OCH2 3-CF3-Ph
G 15-746 CF3 (2-CNPh)C(=0)OCH2 3-CF3-Ph
G 15-747 CF3 (3-CNPh)C(=0)OCH2 3-CF3-Ph
G 15-748 CF3 (4-CNPh)C(=0)OCH2 3-CF3-Ph
G 15-749 CF3 (2-N02Ph)C(=0)OCH2 3-CF3-Ph
G15-750 CF3 (3-N02Ph)C(=0)OCH2 3-CF3-Ph
G15-751 CF3 (4-N02Ph)C(=0)OCH2 3-CF3-Ph
G 15-752 CF3 (2-CF3Ph)C(=0)OCH2 3-CF3-Ph
G15-753 CF3 (3-CF3Ph)C(=0)OCH2 3-CF3-Ph
G 15-754 CF3 (4-CF3Ph)C(=0)OCH2 3-CF3-Ph
G15-755 CF3 CH3 4-CF3-Ph
G 15-756 CF3 CH3CH2 4-CF3-Ph
G15-757 CF3 CH3CH2CH2 4-CF3-Ph
G15-758 CF3 (CH3)2CH 4-CF3-Ph
G15-759 CF3 CH3C(=0) 4-CF3-Ph
G 15-760 CF3 CH3CH2C(=0) 4-CF3-Ph
G15-761 CF3 (CH3)2CHC(=0) 4-CF3-Ph
G 15-762 CF3 (CH3)3CC(=0) 4-CF3-Ph
G 15-763 CF3 (CH3)3CCH2C(=0) 4-CF3-Ph
G 15-764 CF3 CH3CH2CH(CH3)C(=0) 4-CF3-Ph
G 15-765 CF3 (CH3)2CHCH2C(=0) 4-CF3-Ph
G 15-766 CF3 (CH3)3CCH2CH2C(=0) 4-CF3-Ph
G 15-767 CF3 CH3CH2C(CH3)2C(=0) 4-CF3-Ph
G 15-768 CF3 (c-hex)C(=0) 4-CF3-Ph
G 15-769 CF3 (c-pen)C(=0) 4-CF3-Ph
G15-770 CF3 (c-hep)C(=0) 4-CF3-Ph
G15-771 CF3 (c-pro)C(=0) 4-CF3-Ph
G 15-772 CF3 CF3C(=0) 4-CF3-Ph
G15-773 CF3 (CH3)2NC(=0) 4-CF3-Ph
G15-818 CF3 (4-CF3Ph)OCH2 4-CF3-Ph
G15-819 CF3 PhCH2OCH2 4-CF3-Ph
G 15-820 CF3 (2-CH3Ph)CH2OCH2 4-CF3-Ph
G15-821 CF3 (3-CH3Ph)CH2OCH2 4-CF3-Ph
G 15-822 CF3 (4-CH3Ph)CH2OCH2 4-CF3-Ph
G 15-823 CF3 (2-CH3OPh)CH2OCH2 4-CF3-Ph
G 15-824 CF3 (3-CH3OPh)CH2OCH2 4-CF3-Ph
G 15-825 CF3 (4-CH3OPh)CH2OCH2 4-CF3-Ph
G 15-826 CF3 (2-FPh)CH2OCH2 4-CF3-Ph
G 15-827 CF3 (3-FPh)CH2OCH2 4-CF3-Ph
G 15-828 CF3 (4-FPh)CH2OCH2 4-CF3-Ph
G 15-829 CF3 (2-CIPh)CH2OCH2 4-CF3-Ph
G15-830 CF3 (3-CIPh)CH2OCH2 4-CF3-Ph
G15-831 CF3 (4-CIPh)CH2OCH2 4-CF3-Ph
G 15-832 CF3 (2-BrPh)CH2OCH2 4-CF3-Ph
G15-833 CF3 (3-BrPh)CH2OCH2 4-CF3-Ph
G 15-834 CF3 (4-BrPh)CH2OCH2 4-CF3-Ph
G15-835 CF3 (2-CF3OPh)CH2OCH2 4-CF3-Ph
G 15-836 CF3 (3-CF3OPh)CH2OCH2 4-CF3-Ph
G15-837 CF3 (4-CF3OPh)CH2OCH2 4-CF3-Ph
G15-838 CF3 (2-CNPh)CH2OCH2 4-CF3-Ph
G15-839 CF3 (3-CNPh)CH2OCH2 4-CF3-Ph
G 15-840 CF3 (4-CNPh)CH2OCH2 4-CF3-Ph
G15-841 CF3 (2-N02Ph)CH2OCH2 4-CF3-Ph
G 15-842 CF3 (3-N02Ph)CH2OCH2 4-CF3-Ph
G 15-843 CF3 (4-N02Ph)CH2OCH2 4-CF3-Ph
G 15-844 CF3 (2-CF3Ph)CH2OCH2 4-CF3-Ph
G 15-845 CF3 (3-CF3Ph)CH2OCH2 4-CF3-Ph
G 15-846 CF3 (4-CF3Ph)CH2OCH2 4-CF3-Ph
G 15-847 CF3 CH3C(=0)OCH2 4-CF3-Ph
G 15-848 CF3 CH3CH2C(=0)OCH2 4-CF3-Ph
G 15-849 CF3 CH(CH3)2C(=0)OCH2 4-CF3-Ph
G15-850 CF3 (CH3)3C(=0)OCH2 4-CF3-Ph
G15-851 CF3 (CH3)3CCH2(=0)OCH2 4-CF3-Ph
G 15-852 CF3 CH3CH2C(CH3)2C(=0)OCH2 4-CF3-Ph
G15-853 CF3 CF3C(=0)OCH2 4-CF3-Ph
G 15-854 CF3 CF3CF2C(=0)OCH2 4-CF3-Ph
G15-855 CF3 (c-hex)C(=0)OCH2 4-CF3-Ph
G 15-856 CF3 PhC(=0)OCH2 4-CF3-Ph
G15-857 CF3 (2-CH3Ph)C(=0)OCH2 4-CF3-Ph
G15-858 CF3 (3-CH3Ph)C(=0)OCH2 4-CF3-Ph
G15-859 CF3 (4-CH3Ph)C(=0)OCH2 4-CF3-Ph
G 15-860 CF3 (2-CH3OPh)C(=0)OCH2 4-CF3-Ph
G15-861 CF3 (3-CH3OPh)C(=0)OCH2 4-CF3-Ph
G 15-862 CF3 (4-CH3OPh)C(=0)OCH2 4-CF3-Ph
G 15-863 CF3 (2-FPh)C(=0)OCH2 4-CF3-Ph
G 15-864 CF3 (3-FPh)C(=0)OCH2 4-CF3-Ph
G 15-865 CF3 (4-FPh)C(=0)OCH2 4-CF3-Ph
G 15-866 CF3 (2-CIPh)C(=0)OCH2 4-CF3-Ph
G 15-867 CF3 (3-CIPh)C(=0)OCH2 4-CF3-Ph
G 15-868 CF3 (4-CIPh)C(=0)OCH2 4-CF3-Ph
G 15-869 CF3 (2-BrPh)C(=0)OCH2 4-CF3-Ph
G15-870 CF3 (3-BrPh)C(=0)OCH2 4-CF3-Ph
G15-871 CF3 (4-BrPh)C(=0)OCH2 4-CF3-Ph
G 15-872 CF3 (2-CF3OPh)C(=0)OCH2 4-CF3-Ph
G15-873 CF3 (3-CF3OPh)C(=0)OCH2 4-CF3-Ph
G 15-874 CF3 (4-CF3OPh)C(=0)OCH2 4-CF3-Ph
G15-875 CF3 (2-CNPh)C(=0)OCH2 4-CF3-Ph
G 15-876 CF3 (3-CNPh)C(=0)OCH2 4-CF3-Ph
G15-877 CF3 (4-CNPh)C(=0)OCH2 4-CF3-Ph
G15-878 CF3 (2-N02Ph)C(=0)OCH2 4-CF3-Ph
G15-879 CF3 (3-N02Ph)C(=0)OCH2 4-CF3-Ph
G15-880 CF3 (4-N02Ph)C(=0)OCH2 4-CF3-Ph
G15-881 CF3 (2-CF3Ph)C(=0)OCH2 4-CF3-Ph
G 15-882 CF3 (3-CF3Ph)C(=0)OCH2 4-CF3-Ph
G15-883 CF3 (4-CF3Ph)C(=0)OCH2 4-CF3-Ph
[0306] Table 9 d
G16-156 CF3 (2-CH3OPh)OCH2
G16-157 CF3 (3-CH3OPh)OCH2
G16-158 CF3 (4-CH3OPh)OCH2
G16-159 CF3 (2-FPh)OCH2
G16-160 CF3 (3-FPh)OCH2
G16-161 CF3 (4-FPh)OCH2
G16-162 CF3 (2-CIPh)OCH2
G16-163 CF3 (3-CIPh)OCH2
G16-164 CF3 (4-CIPh)OCH2
G16-165 CF3 (2-BrPh)OCH2
G16-166 CF3 (3-BrPh)OCH2
G16-167 CF3 (4-BrPh)OCH2
G16-168 CF3 (2-CF3OPh)OCH2
G16-169 CF3 (3-CF3OPh)OCH2
G16-170 CF3 (4-CF3OPh)OCH2
G16-171 CF3 (2-CNPh)OCH2
G16-172 CF3 (3-CNPh)OCH2
G16-173 CF3 (4-CNPh)OCH2
G16-174 CF3 (2-N02Ph)OCH2
G16-175 CF3 (3-N02Ph)OCH2
G16-176 CF3 (4-N02Ph)OCH2
G16-177 CF3 (2-CF3Ph)OCH2
G16-178 CF3 (3-CF3Ph)OCH2
G16-179 CF3 (4-CF3Ph)OCH2
G16-180 CF3 PhCH2OCH2
G16-181 CF3 (2-CH3Ph)CH2OCH2
G16-182 CF3 (3-CH3Ph)CH2OCH2
G16-183 CF3 (4-CH3Ph)CH2OCH2
G16-184 CF3 (2-CH3OPh)CH2OCH2
G16-185 CF3 (3-CH3OPh)CH2OCH2
G16-186 CF3 (4-CH3OPh)CH2OCH2
G16-187 CF3 (2-FPh)CH2OCH2
G16-188 CF3 (3-FPh)CH2OCH2
G16-189 CF3 (4-FPh)CH2OCH2
G16-190 CF3 (2-CIPh)CH2OCH2
G16-191 CF3 (3-CIPh)CH2OCH2
G16-192 CF3 (4-CIPh)CH2OCH2
G16-193 CF3 (2-BrPh)CH2OCH2
G16-194 CF3 (3-BrPh)CH2OCH2
G16-195 CF3 (4-BrPh)CH2OCH2
G16-196 CF3 (2-CF3OPh)CH2OCH2
G16-197 CF3 (3-CF3OPh)CH2OCH2
G16-198 CF3 (4-CF3OPh)CH2OCH2
G16-199 CF3 (2-CNPh)CH2OCH2
G 16-200 CF3 (3-CNPh)CH2OCH2
G16-201 CF3 (4-CNPh)CH2OCH2
G 16-202 CF3 (2-N02Ph)CH2OCH2
G 16-294 2-CF3Ph (2-BrPh)OCH2
G 16-295 2-CF3Ph (3-BrPh)OCH2
G 16-296 2-CF3Ph (4-BrPh)OCH2
G 16-297 2-CF3Ph (2-CF3OPh)OCH2
G 16-298 2-CF3Ph (3-CF3OPh)OCH2
G 16-299 2-CF3Ph (4-CF3OPh)OCH2
G16-300 2-CF3Ph (2-CNPh)OCH2
G16-301 2-CF3Ph (3-CNPh)OCH2
G 16-302 2-CF3Ph (4-CNPh)OCH2
G16-303 2-CF3Ph (2-N02Ph)OCH2
G 16-304 2-CF3Ph (3-N02Ph)OCH2
G16-305 2-CF3Ph (4-N02Ph)OCH2
G 16-306 2-CF3Ph (2-CF3Ph)OCH2
G16-307 2-CF3Ph (3-CF3Ph)OCH2
G16-308 2-CF3Ph (4-CF3Ph)OCH2
G16-309 2-CF3Ph PhCH2OCH2
G16-310 2-CF3Ph (2-CH3Ph)CH2OCH2
G16-311 2-CF3Ph (3-CH3Ph)CH2OCH2
G16-312 2-CF3Ph (4-CH3Ph)CH2OCH2
G16-313 2-CF3Ph (2-CH3OPh)CH2OCH2
G16-314 2-CF3Ph (3-CH3OPh)CH2OCH2
G16-315 2-CF3Ph (4-CH3OPh)CH2OCH2
G16-316 2-CF3Ph (2-FPh)CH2OCH2
G16-317 2-CF3Ph (3-FPh)CH2OCH2
G16-318 2-CF3Ph (4-FPh)CH2OCH2
G16-319 2-CF3Ph (2-CIPh)CH2OCH2
G 16-320 2-CF3Ph (3-CIPh)CH2OCH2
G16-321 2-CF3Ph (4-CIPh)CH2OCH2
G 16-322 2-CF3Ph (2-BrPh)CH2OCH2
G 16-323 2-CF3Ph (3-BrPh)CH2OCH2
G 16-324 2-CF3Ph (4-BrPh)CH2OCH2
G 16-325 2-CF3Ph (2-CF3OPh)CH2OCH2
G 16-326 2-CF3Ph (3-CF3OPh)CH2OCH2
G 16-327 2-CF3Ph (4-CF3OPh)CH2OCH2
G 16-328 2-CF3Ph (2-CNPh)CH2OCH2
G 16-329 2-CF3Ph (3-CNPh)CH2OCH2
G16-330 2-CF3Ph (4-CNPh)CH2OCH2
G16-331 2-CF3Ph (2-N02Ph)CH2OCH2
G 16-332 2-CF3Ph (3-N02Ph)CH2OCH2
G16-333 2-CF3Ph (4-N02Ph)CH2OCH2
G 16-334 2-CF3Ph (2-CF3Ph)CH2OCH2
G16-335 2-CF3Ph (3-CF3Ph)CH2OCH2
G 16-336 2-CF3Ph (4-CF3Ph)CH2OCH2
G16-337 2-CF3Ph CH3C(=0)OCH2
G16-338 2-CF3Ph CH3CH2C(=0)OCH2
G16-339 2-CF3Ph CH(CH3)2C(=0)OCH2
G 16-432 3-CF3Ph (2-N02Ph)OCH2
G 16-433 3-CF3Ph (3-N02Ph)OCH2
G 16-434 3-CF3Ph (4-N02Ph)OCH2
G 16-435 3-CF3Ph (2-CF3Ph)OCH2
G 16-436 3-CF3Ph (3-CF3Ph)OCH2
G 16-437 3-CF3Ph (4-CF3Ph)OCH2
G 16-438 3-CF3Ph PhCH2OCH2
G 16-439 3-CF3Ph (2-CH3Ph)CH2OCH2
G 16-440 3-CF3Ph (3-CH3Ph)CH2OCH2
G 16-441 3-CF3Ph (4-CH3Ph)CH2OCH2
G 16-442 3-CF3Ph (2-CH3OPh)CH2OCH2
G 16-443 3-CF3Ph (3-CH3OPh)CH2OCH2
G 16-444 3-CF3Ph (4-CH3OPh)CH2OCH2
G 16-445 3-CF3Ph (2-FPh)CH2OCH2
G 16-446 3-CF3Ph (3-FPh)CH2OCH2
G 16-447 3-CF3Ph (4-FPh)CH2OCH2
G 16-448 3-CF3Ph (2-CIPh)CH2OCH2
G 16-449 3-CF3Ph (3-CIPh)CH2OCH2
G 16-450 3-CF3Ph (4-CIPh)CH2OCH2
G16-451 3-CF3Ph (2-BrPh)CH2OCH2
G 16-452 3-CF3Ph (3-BrPh)CH2OCH2
G 16-453 3-CF3Ph (4-BrPh)CH2OCH2
G 16-454 3-CF3Ph (2-CF3OPh)CH2OCH2
G 16-455 3-CF3Ph (3-CF3OPh)CH2OCH2
G 16-456 3-CF3Ph (4-CF3OPh)CH2OCH2
G 16-457 3-CF3Ph (2-CNPh)CH2OCH2
G 16-458 3-CF3Ph (3-CNPh)CH2OCH2
G 16-459 3-CF3Ph (4-CNPh)CH2OCH2
G 16-460 3-CF3Ph (2-N02Ph)CH2OCH2
G 16-461 3-CF3Ph (3-N02Ph)CH2OCH2
G 16-462 3-CF3Ph (4-N02Ph)CH2OCH2
G 16-463 3-CF3Ph (2-CF3Ph)CH2OCH2
G 16-464 3-CF3Ph (3-CF3Ph)CH2OCH2
G 16-465 3-CF3Ph (4-CF3Ph)CH2OCH2
G 16-466 3-CF3Ph CH3C(=0)OCH2
G 16-467 3-CF3Ph CH3CH2C(=0)OCH2
G 16-468 3-CF3Ph CH(CH3)2C(=0)OCH2
G 16-469 3-CF3Ph (CH3)3C(=0)OCH2
G 16-470 3-CF3Ph (CH3)3CCH2(=0)OCH2
G16-471 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 16-472 3-CF3Ph CF3C(=0)OCH2
G 16-473 3-CF3Ph CF3CF2C(=0)OCH2
G 16-474 3-CF3Ph (c-hex)C(=0)OCH2
G 16-475 3-CF3Ph PhC(=0)OCH2
G 16-476 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G 16-477 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G16-570 4-CF3Ph (4-CH3Ph)CH2OCH2
G16-571 4-CF3Ph (2-CH3OPh)CH2OCH2
G 16-572 4-CF3Ph (3-CH3OPh)CH2OCH2
G16-573 4-CF3Ph (4-CH3OPh)CH2OCH2
G 16-574 4-CF3Ph (2-FPh)CH2OCH2
G16-575 4-CF3Ph (3-FPh)CH2OCH2
G 16-576 4-CF3Ph (4-FPh)CH2OCH2
G16-577 4-CF3Ph (2-CIPh)CH2OCH2
G16-578 4-CF3Ph (3-CIPh)CH2OCH2
G16-579 4-CF3Ph (4-CIPh)CH2OCH2
G16-580 4-CF3Ph (2-BrPh)CH2OCH2
G16-581 4-CF3Ph (3-BrPh)CH2OCH2
G 16-582 4-CF3Ph (4-BrPh)CH2OCH2
G16-583 4-CF3Ph (2-CF3OPh)CH2OCH2
G 16-584 4-CF3Ph (3-CF3OPh)CH2OCH2
G16-585 4-CF3Ph (4-CF3OPh)CH2OCH2
G 16-586 4-CF3Ph (2-CNPh)CH2OCH2
G16-587 4-CF3Ph (3-CNPh)CH2OCH2
G16-588 4-CF3Ph (4-CNPh)CH2OCH2
G16-589 4-CF3Ph (2-N02Ph)CH2OCH2
G16-590 4-CF3Ph (3-N02Ph)CH2OCH2
G16-591 4-CF3Ph (4-N02Ph)CH2OCH2
G 16-592 4-CF3Ph (2-CF3Ph)CH2OCH2
G16-593 4-CF3Ph (3-CF3Ph)CH2OCH2
G 16-594 4-CF3Ph (4-CF3Ph)CH2OCH2
G16-595 4-CF3Ph CH3C(=0)OCH2
G 16-596 4-CF3Ph CH3CH2C(=0)OCH2
G16-597 4-CF3Ph CH(CH3)2C(=0)OCH2
G16-598 4-CF3Ph (CH3)3C(=0)OCH2
G16-599 4-CF3Ph (CH3)3CCH2(=0)OCH2
G 16-600 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G16-601 4-CF3Ph CF3C(=0)OCH2
G 16-602 4-CF3Ph CF3CF2C(=0)OCH2
G 16-603 4-CF3Ph (c-hex)C(=0)OCH2
G 16-604 4-CF3Ph PhC(=0)OCH2
G 16-605 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G 16-606 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G 16-607 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G 16-608 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G 16-609 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G16-610 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G16-611 4-CF3Ph (2-FPh)C(=0)OCH2
G16-612 4-CF3Ph (3-FPh)C(=0)OCH2
G16-613 4-CF3Ph (4-FPh)C(=0)OCH2
G16-614 4-CF3Ph (2-CIPh)C(=0)OCH2
G16-615 4-CF3Ph (3-CIPh)C(=0)OCH2
G16-616 4-CF3Ph (4-CIPh)C(=0)OCH2
G16-707 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G16-708 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G16-709 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G16-710 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G16-711 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G16-712 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G16-713 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G16-714 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G16-715 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G16-716 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G16-717 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G16-718 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G16-719 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G 16-720 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G16-721 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G 16-722 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G 16-723 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G 16-724 3,5-(CF3)2Ph CH3C(=0)OCH2
G 16-725 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G 16-726 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G 16-727 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G 16-728 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G 16-729 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G16-730 3,5-(CF3)2Ph CF3C(=0)OCH2
G16-731 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G 16-732 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G16-733 3,5-(CF3)2Ph PhC(=0)OCH2
G 16-734 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G16-735 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G 16-736 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G16-737 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G16-738 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G16-739 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G 16-740 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G16-741 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G 16-742 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G 16-743 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G 16-744 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G 16-745 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G 16-746 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G 16-747 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G 16-748 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G 16-749 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G16-750 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G16-751 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G 16-752 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G16-753 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G 16-754 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G16-755 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G 16-756 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G16-757 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G16-758 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G16-759 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G 16-760 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0307] Table 9 e
G17-168 CF3 (2-CF3OPh)OCH2
G17-169 CF3 (3-CF3OPh)OCH2
G17-170 CF3 (4-CF3OPh)OCH2
G17-171 CF3 (2-CNPh)OCH2
G17-172 CF3 (3-CNPh)OCH2
G17-173 CF3 (4-CNPh)OCH2
G17-174 CF3 (2-N02Ph)OCH2
G17-175 CF3 (3-N02Ph)OCH2
G17-176 CF3 (4-N02Ph)OCH2
G17-177 CF3 (2-CF3Ph)OCH2
G17-178 CF3 (3-CF3Ph)OCH2
G17-179 CF3 (4-CF3Ph)OCH2
G17-180 CF3 PhCH2OCH2
G17-181 CF3 (2-CH3Ph)CH2OCH2
G17-182 CF3 (3-CH3Ph)CH2OCH2
G17-183 CF3 (4-CH3Ph)CH2OCH2
G17-184 CF3 (2-CH3OPh)CH2OCH2
G17-185 CF3 (3-CH3OPh)CH2OCH2
G17-186 CF3 (4-CH3OPh)CH2OCH2
G17-187 CF3 (2-FPh)CH2OCH2
G17-188 CF3 (3-FPh)CH2OCH2
G17-189 CF3 (4-FPh)CH2OCH2
G17-190 CF3 (2-CIPh)CH2OCH2
G17-191 CF3 (3-CIPh)CH2OCH2
G17-192 CF3 (4-CIPh)CH2OCH2
G17-193 CF3 (2-BrPh)CH2OCH2
G17-194 CF3 (3-BrPh)CH2OCH2
G17-195 CF3 (4-BrPh)CH2OCH2
G17-196 CF3 (2-CF3OPh)CH2OCH2
G17-197 CF3 (3-CF3OPh)CH2OCH2
G17-198 CF3 (4-CF3OPh)CH2OCH2
G17-199 CF3 (2-CNPh)CH2OCH2
G 17-200 CF3 (3-CNPh)CH2OCH2
G17-201 CF3 (4-CNPh)CH2OCH2
G 17-202 CF3 (2-N02Ph)CH2OCH2
G 17-203 CF3 (3-N02Ph)CH2OCH2
G 17-204 CF3 (4-N02Ph)CH2OCH2
G 17-205 CF3 (2-CF3Ph)CH2OCH2
G 17-206 CF3 (3-CF3Ph)CH2OCH2
G 17-207 CF3 (4-CF3Ph)CH2OCH2
G 17-208 CF3 CH3C(=0)OCH2
G 17-209 CF3 CH3CH2C(=0)OCH2
G17-210 CF3 CH(CH3)2C(=0)OCH2
G17-211 CF3 (CH3)3C(=0)OCH2
G17-212 CF3 (CH3)3CCH2(=0)OCH2
G17-213 CF3 CH3CH2C(CH3)2C(=0)OCH2
G 17-306 2-CF3Ph (2-CF3Ph)OCH2
G17-307 2-CF3Ph (3-CF3Ph)OCH2
G17-308 2-CF3Ph (4-CF3Ph)OCH2
G17-309 2-CF3Ph PhCH2OCH2
G17-310 2-CF3Ph (2-CH3Ph)CH2OCH2
G17-311 2-CF3Ph (3-CH3Ph)CH2OCH2
G17-312 2-CF3Ph (4-CH3Ph)CH2OCH2
G17-313 2-CF3Ph (2-CH3OPh)CH2OCH2
G17-314 2-CF3Ph (3-CH3OPh)CH2OCH2
G17-315 2-CF3Ph (4-CH3OPh)CH2OCH2
G17-316 2-CF3Ph (2-FPh)CH2OCH2
G17-317 2-CF3Ph (3-FPh)CH2OCH2
G17-318 2-CF3Ph (4-FPh)CH2OCH2
G17-319 2-CF3Ph (2-CIPh)CH2OCH2
G 17-320 2-CF3Ph (3-CIPh)CH2OCH2
G17-321 2-CF3Ph (4-CIPh)CH2OCH2
G 17-322 2-CF3Ph (2-BrPh)CH2OCH2
G 17-323 2-CF3Ph (3-BrPh)CH2OCH2
G 17-324 2-CF3Ph (4-BrPh)CH2OCH2
G 17-325 2-CF3Ph (2-CF3OPh)CH2OCH2
G 17-326 2-CF3Ph (3-CF3OPh)CH2OCH2
G 17-327 2-CF3Ph (4-CF3OPh)CH2OCH2
G 17-328 2-CF3Ph (2-CNPh)CH2OCH2
G 17-329 2-CF3Ph (3-CNPh)CH2OCH2
G17-330 2-CF3Ph (4-CNPh)CH2OCH2
G17-331 2-CF3Ph (2-N02Ph)CH2OCH2
G 17-332 2-CF3Ph (3-N02Ph)CH2OCH2
G17-333 2-CF3Ph (4-N02Ph)CH2OCH2
G 17-334 2-CF3Ph (2-CF3Ph)CH2OCH2
G17-335 2-CF3Ph (3-CF3Ph)CH2OCH2
G 17-336 2-CF3Ph (4-CF3Ph)CH2OCH2
G17-337 2-CF3Ph CH3C(=0)OCH2
G17-338 2-CF3Ph CH3CH2C(=0)OCH2
G17-339 2-CF3Ph CH(CH3)2C(=0)OCH2
G 17-340 2-CF3Ph (CH3)3C(=0)OCH2
G17-341 2-CF3Ph (CH3)3CCH2(=0)OCH2
G 17-342 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 17-343 2-CF3Ph CF3C(=0)OCH2
G 17-344 2-CF3Ph CF3CF2C(=0)OCH2
G 17-345 2-CF3Ph (c-hex)C(=0)OCH2
G 17-346 2-CF3Ph PhC(=0)OCH2
G 17-347 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G 17-348 2-CF3Ph (3-CH3Ph)C(=0)OCH2
G 17-349 2-CF3Ph (4-CH3Ph)C(=0)OCH2
G17-350 2-CF3Ph (2-CH3OPh)C(=0)OCH2
G17-351 2-CF3Ph (3-CH3OPh)C(=0)OCH2
G 17-443 3-CF3Ph (3-CH3OPh)CH2OCH2
G 17-444 3-CF3Ph (4-CH3OPh)CH2OCH2
G 17-445 3-CF3Ph (2-FPh)CH2OCH2
G 17-446 3-CF3Ph (3-FPh)CH2OCH2
G 17-447 3-CF3Ph (4-FPh)CH2OCH2
G 17-448 3-CF3Ph (2-CIPh)CH2OCH2
G 17-449 3-CF3Ph (3-CIPh)CH2OCH2
G 17-450 3-CF3Ph (4-CIPh)CH2OCH2
G17-451 3-CF3Ph (2-BrPh)CH2OCH2
G 17-452 3-CF3Ph (3-BrPh)CH2OCH2
G 17-453 3-CF3Ph (4-BrPh)CH2OCH2
G 17-454 3-CF3Ph (2-CF3OPh)CH2OCH2
G 17-455 3-CF3Ph (3-CF3OPh)CH2OCH2
G 17-456 3-CF3Ph (4-CF3OPh)CH2OCH2
G 17-457 3-CF3Ph (2-CNPh)CH2OCH2
G 17-458 3-CF3Ph (3-CNPh)CH2OCH2
G 17-459 3-CF3Ph (4-CNPh)CH2OCH2
G 17-460 3-CF3Ph (2-N02Ph)CH2OCH2
G 17-461 3-CF3Ph (3-N02Ph)CH2OCH2
G 17-462 3-CF3Ph (4-N02Ph)CH2OCH2
G 17-463 3-CF3Ph (2-CF3Ph)CH2OCH2
G 17-464 3-CF3Ph (3-CF3Ph)CH2OCH2
G 17-465 3-CF3Ph (4-CF3Ph)CH2OCH2
G 17-466 3-CF3Ph CH3C(=0)OCH2
G 17-467 3-CF3Ph CH3CH2C(=0)OCH2
G 17-468 3-CF3Ph CH(CH3)2C(=0)OCH2
G 17-469 3-CF3Ph (CH3)3C(=0)OCH2
G 17-470 3-CF3Ph (CH3)3CCH2(=0)OCH2
G17-471 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 17-472 3-CF3Ph CF3C(=0)OCH2
G 17-473 3-CF3Ph CF3CF2C(=0)OCH2
G 17-474 3-CF3Ph (c-hex)C(=0)OCH2
G 17-475 3-CF3Ph PhC(=0)OCH2
G 17-476 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G 17-477 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G 17-478 3-CF3Ph (4-CH3Ph)C(=0)OCH2
G 17-479 3-CF3Ph (2-CH3OPh)C(=0)OCH2
G 17-480 3-CF3Ph (3-CH3OPh)C(=0)OCH2
G17-481 3-CF3Ph (4-CH3OPh)C(=0)OCH2
G 17-482 3-CF3Ph (2-FPh)C(=0)OCH2
G 17-483 3-CF3Ph (3-FPh)C(=0)OCH2
G 17-484 3-CF3Ph (4-FPh)C(=0)OCH2
G 17-485 3-CF3Ph (2-CIPh)C(=0)OCH2
G 17-486 3-CF3Ph (3-CIPh)C(=0)OCH2
G 17-487 3-CF3Ph (4-CIPh)C(=0)OCH2
G 17-488 3-CF3Ph (2-BrPh)C(=0)OCH2
G 17-489 3-CF3Ph (3-BrPh)C(=0)OCH2
G17-533 4-CF3Ph CH3CH2OCH2
G 17-534 4-CF3Ph (CH3)2CHOCH2
G17-535 4-CF3Ph (CH3)3COCH2
G 17-536 4-CF3Ph (CH3)3CCH20CH2
G17-537 4-CF3Ph CH3CH2C(CH3)2OCH2
G17-538 4-CF3Ph (c-hex)OCH2
G17-539 4-CF3Ph PhOCH2
G 17-540 4-CF3Ph (2-CH3Ph)OCH2
G17-541 4-CF3Ph (3-CH3Ph)OCH2
G 17-542 4-CF3Ph (4-CH3Ph)OCH2
G 17-543 4-CF3Ph (2-CH3OPh)OCH2
G 17-544 4-CF3Ph (3-CH3OPh)OCH2
G 17-545 4-CF3Ph (4-CH3OPh)OCH2
G 17-546 4-CF3Ph (2-FPh)OCH2
G 17-547 4-CF3Ph (3-FPh)OCH2
G 17-548 4-CF3Ph (4-FPh)OCH2
G 17-549 4-CF3Ph (2-CIPh)OCH2
G17-550 4-CF3Ph (3-CIPh)OCH2
G17-551 4-CF3Ph (4-CIPh)OCH2
G 17-552 4-CF3Ph (2-BrPh)OCH2
G17-553 4-CF3Ph (3-BrPh)OCH2
G 17-554 4-CF3Ph (4-BrPh)OCH2
G17-555 4-CF3Ph (2-CF3OPh)OCH2
G 17-556 4-CF3Ph (3-CF3OPh)OCH2
G17-557 4-CF3Ph (4-CF3OPh)OCH2
G17-558 4-CF3Ph (2-CNPh)OCH2
G17-559 4-CF3Ph (3-CNPh)OCH2
G 17-560 4-CF3Ph (4-CNPh)OCH2
G17-561 4-CF3Ph (2-N02Ph)OCH2
G 17-562 4-CF3Ph (3-N02Ph)OCH2
G 17-563 4-CF3Ph (4-N02Ph)OCH2
G 17-564 4-CF3Ph (2-CF3Ph)OCH2
G 17-565 4-CF3Ph (3-CF3Ph)OCH2
G 17-566 4-CF3Ph (4-CF3Ph)OCH2
G 17-567 4-CF3Ph PhCH2OCH2
G 17-568 4-CF3Ph (2-CH3Ph)CH2OCH2
G 17-569 4-CF3Ph (3-CH3Ph)CH2OCH2
G17-570 4-CF3Ph (4-CH3Ph)CH2OCH2
G17-571 4-CF3Ph (2-CH3OPh)CH2OCH2
G 17-572 4-CF3Ph (3-CH3OPh)CH2OCH2
G17-573 4-CF3Ph (4-CH3OPh)CH2OCH2
G 17-574 4-CF3Ph (2-FPh)CH2OCH2
G17-575 4-CF3Ph (3-FPh)CH2OCH2
G 17-576 4-CF3Ph (4-FPh)CH2OCH2
G17-577 4-CF3Ph (2-CIPh)CH2OCH2
G17-578 4-CF3Ph (3-CIPh)CH2OCH2
G17-579 4-CF3Ph (4-CIPh)CH2OCH2
G17-580 4-CF3Ph (2-BrPh)CH2OCH2
G17-581 4-CF3Ph (3-BrPh)CH2OCH2
G 17-582 4-CF3Ph (4-BrPh)CH2OCH2
G17-583 4-CF3Ph (2-CF3OPh)CH2OCH2
G 17-584 4-CF3Ph (3-CF3OPh)CH2OCH2
G17-585 4-CF3Ph (4-CF3OPh)CH2OCH2
G 17-586 4-CF3Ph (2-CNPh)CH2OCH2
G17-587 4-CF3Ph (3-CNPh)CH2OCH2
G17-588 4-CF3Ph (4-CNPh)CH2OCH2
G17-589 4-CF3Ph (2-N02Ph)CH2OCH2
G17-590 4-CF3Ph (3-N02Ph)CH2OCH2
G17-591 4-CF3Ph (4-N02Ph)CH2OCH2
G 17-592 4-CF3Ph (2-CF3Ph)CH2OCH2
G17-593 4-CF3Ph (3-CF3Ph)CH2OCH2
G 17-594 4-CF3Ph (4-CF3Ph)CH2OCH2
G17-595 4-CF3Ph CH3C(=0)OCH2
G 17-596 4-CF3Ph CH3CH2C(=0)OCH2
G17-597 4-CF3Ph CH(CH3)2C(=0)OCH2
G17-598 4-CF3Ph (CH3)3C(=0)OCH2
G17-599 4-CF3Ph (CH3)3CCH2(=0)OCH2
G 17-600 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G17-601 4-CF3Ph CF3C(=0)OCH2
G 17-602 4-CF3Ph CF3CF2C(=0)OCH2
G 17-603 4-CF3Ph (c-hex)C(=0)OCH2
G 17-604 4-CF3Ph PhC(=0)OCH2
G 17-605 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G 17-606 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G 17-607 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G 17-608 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G 17-609 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G17-610 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G17-611 4-CF3Ph (2-FPh)C(=0)OCH2
G17-612 4-CF3Ph (3-FPh)C(=0)OCH2
G17-613 4-CF3Ph (4-FPh)C(=0)OCH2
G17-614 4-CF3Ph (2-CIPh)C(=0)OCH2
G17-615 4-CF3Ph (3-CIPh)C(=0)OCH2
G17-616 4-CF3Ph (4-CIPh)C(=0)OCH2
G17-617 4-CF3Ph (2-BrPh)C(=0)OCH2
G17-618 4-CF3Ph (3-BrPh)C(=0)OCH2
G17-619 4-CF3Ph (4-BrPh)C(=0)OCH2
G 17-620 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G 17-621 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G 17-622 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G 17-623 4-CF3Ph (2-CNPh)C(=0)OCH2
G 17-624 4-CF3Ph (3-CNPh)C(=0)OCH2
G 17-625 4-CF3Ph (4-CNPh)C(=0)OCH2
G 17-626 4-CF3Ph (2-N02Ph)C(=0)OCH2
G 17-627 4-CF3Ph (3-N02Ph)C(=0)OCH2
G17-671 3,5-(CF3)2Ph (4-CH3Ph)OCH2
G 17-672 3,5-(CF3)2Ph (2-CH3OPh)OCH2
G 17-673 3,5-(CF3)2Ph (3-CH3OPh)OCH2
G 17-674 3,5-(CF3)2Ph (4-CH3OPh)OCH2
G 17-675 3,5-(CF3)2Ph (2-FPh)OCH2
G 17-676 3,5-(CF3)2Ph (3-FPh)OCH2
G 17-677 3,5-(CF3)2Ph (4-FPh)OCH2
G 17-678 3,5-(CF3)2Ph (2-CIPh)OCH2
G 17-679 3,5-(CF3)2Ph (3-CIPh)OCH2
G 17-680 3,5-(CF3)2Ph (4-CIPh)OCH2
G17-681 3,5-(CF3)2Ph (2-BrPh)OCH2
G 17-682 3,5-(CF3)2Ph (3-BrPh)OCH2
G 17-683 3,5-(CF3)2Ph (4-BrPh)OCH2
G 17-684 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G 17-685 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G 17-686 3,5-(CF3)2Ph (4-CF3OPh)OCH2
G 17-687 3,5-(CF3)2Ph (2-CNPh)OCH2
G 17-688 3,5-(CF3)2Ph (3-CNPh)OCH2
G 17-689 3,5-(CF3)2Ph (4-CNPh)OCH2
G 17-690 3,5-(CF3)2Ph (2-N02Ph)OCH2
G17-691 3,5-(CF3)2Ph (3-N02Ph)OCH2
G 17-692 3,5-(CF3)2Ph (4-N02Ph)OCH2
G 17-693 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G 17-694 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G 17-695 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G 17-696 3,5-(CF3)2Ph PhCH2OCH2
G 17-697 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G 17-698 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G 17-699 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G17-700 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G17-701 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G 17-702 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G17-703 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G 17-704 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G17-705 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G 17-706 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G17-707 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G17-708 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G17-709 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G17-710 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G17-711 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G17-712 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G17-713 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G17-714 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G17-715 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G17-716 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G17-717 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G17-718 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G17-719 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G 17-720 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G17-721 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G 17-722 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G 17-723 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G 17-724 3,5-(CF3)2Ph CH3C(=0)OCH2
G 17-725 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G 17-726 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G 17-727 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G 17-728 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G 17-729 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G17-730 3,5-(CF3)2Ph CF3C(=0)OCH2
G17-731 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G 17-732 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G17-733 3,5-(CF3)2Ph PhC(=0)OCH2
G 17-734 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G17-735 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G 17-736 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G17-737 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G17-738 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G17-739 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G 17-740 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G17-741 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G 17-742 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G 17-743 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G 17-744 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G 17-745 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G 17-746 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G 17-747 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G 17-748 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G 17-749 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G17-750 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G17-751 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G 17-752 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G17-753 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G 17-754 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G17-755 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G 17-756 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G17-757 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G17-758 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G17-759 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G 17-760 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
G18-178 CF3 (3-CF3Ph)OCH2
G18-179 CF3 (4-CF3Ph)OCH2
G18-180 CF3 PhCH2OCH2
G18-181 CF3 (2-CH3Ph)CH2OCH2
G18-182 CF3 (3-CH3Ph)CH2OCH2
G18-183 CF3 (4-CH3Ph)CH2OCH2
G18-184 CF3 (2-CH3OPh)CH2OCH2
G18-185 CF3 (3-CH3OPh)CH2OCH2
G18-186 CF3 (4-CH3OPh)CH2OCH2
G18-187 CF3 (2-FPh)CH2OCH2
G18-188 CF3 (3-FPh)CH2OCH2
G18-189 CF3 (4-FPh)CH2OCH2
G18-190 CF3 (2-CIPh)CH2OCH2
G18-191 CF3 (3-CIPh)CH2OCH2
G18-192 CF3 (4-CIPh)CH2OCH2
G18-193 CF3 (2-BrPh)CH2OCH2
G18-194 CF3 (3-BrPh)CH2OCH2
G18-195 CF3 (4-BrPh)CH2OCH2
G18-196 CF3 (2-CF3OPh)CH2OCH2
G18-197 CF3 (3-CF3OPh)CH2OCH2
G18-198 CF3 (4-CF3OPh)CH2OCH2
G18-199 CF3 (2-CNPh)CH2OCH2
G 18-200 CF3 (3-CNPh)CH2OCH2
G18-201 CF3 (4-CNPh)CH2OCH2
G 18-202 CF3 (2-N02Ph)CH2OCH2
G 18-203 CF3 (3-N02Ph)CH2OCH2
G 18-204 CF3 (4-N02Ph)CH2OCH2
G 18-205 CF3 (2-CF3Ph)CH2OCH2
G 18-206 CF3 (3-CF3Ph)CH2OCH2
G 18-207 CF3 (4-CF3Ph)CH2OCH2
G 18-208 CF3 CH3C(=0)OCH2
G 18-209 CF3 CH3CH2C(=0)OCH2
G18-210 CF3 CH(CH3)2C(=0)OCH2
G18-211 CF3 (CH3)3C(=0)OCH2
G18-212 CF3 (CH3)3CCH2(=0)OCH2
G18-213 CF3 CH3CH2C(CH3)2C(=0)OCH2
G18-214 CF3 CF3C(=0)OCH2
G18-215 CF3 CF3CF2C(=0)OCH2
G18-216 CF3 (c-hex)C(=0)OCH2
G18-217 CF3 PhC(=0)OCH2
G18-218 CF3 (2-CH3Ph)C(=0)OCH2
G18-219 CF3 (3-CH3Ph)C(=0)OCH2
G 18-220 CF3 (4-CH3Ph)C(=0)OCH2
G 18-221 CF3 (2-CH3OPh)C(=0)OCH2
G 18-222 CF3 (3-CH3OPh)C(=0)OCH2
G 18-223 CF3 (4-CH3OPh)C(=0)OCH2
G18-314 2-CF3Ph (3-CH3OPh)CH2OCH2
G18-315 2-CF3Ph (4-CH3OPh)CH2OCH2
G18-316 2-CF3Ph (2-FPh)CH2OCH2
G18-317 2-CF3Ph (3-FPh)CH2OCH2
G18-318 2-CF3Ph (4-FPh)CH2OCH2
G18-319 2-CF3Ph (2-CIPh)CH2OCH2
G 18-320 2-CF3Ph (3-CIPh)CH2OCH2
G18-321 2-CF3Ph (4-CIPh)CH2OCH2
G 18-322 2-CF3Ph (2-BrPh)CH2OCH2
G 18-323 2-CF3Ph (3-BrPh)CH2OCH2
G 18-324 2-CF3Ph (4-BrPh)CH2OCH2
G 18-325 2-CF3Ph (2-CF3OPh)CH2OCH2
G 18-326 2-CF3Ph (3-CF3OPh)CH2OCH2
G 18-327 2-CF3Ph (4-CF3OPh)CH2OCH2
G 18-328 2-CF3Ph (2-CNPh)CH2OCH2
G 18-329 2-CF3Ph (3-CNPh)CH2OCH2
G18-330 2-CF3Ph (4-CNPh)CH2OCH2
G18-331 2-CF3Ph (2-N02Ph)CH2OCH2
G 18-332 2-CF3Ph (3-N02Ph)CH2OCH2
G18-333 2-CF3Ph (4-N02Ph)CH2OCH2
G 18-334 2-CF3Ph (2-CF3Ph)CH2OCH2
G18-335 2-CF3Ph (3-CF3Ph)CH2OCH2
G 18-336 2-CF3Ph (4-CF3Ph)CH2OCH2
G18-337 2-CF3Ph CH3C(=0)OCH2
G18-338 2-CF3Ph CH3CH2C(=0)OCH2
G18-339 2-CF3Ph CH(CH3)2C(=0)OCH2
G 18-340 2-CF3Ph (CH3)3C(=0)OCH2
G18-341 2-CF3Ph (CH3)3CCH2(=0)OCH2
G 18-342 2-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 18-343 2-CF3Ph CF3C(=0)OCH2
G 18-344 2-CF3Ph CF3CF2C(=0)OCH2
G 18-345 2-CF3Ph (c-hex)C(=0)OCH2
G 18-346 2-CF3Ph PhC(=0)OCH2
G 18-347 2-CF3Ph (2-CH3Ph)C(=0)OCH2
G 18-348 2-CF3Ph (3-CH3Ph)C(=0)OCH2
G 18-349 2-CF3Ph (4-CH3Ph)C(=0)OCH2
G18-350 2-CF3Ph (2-CH3OPh)C(=0)OCH2
G18-351 2-CF3Ph (3-CH3OPh)C(=0)OCH2
G 18-352 2-CF3Ph (4-CH3OPh)C(=0)OCH2
G18-353 2-CF3Ph (2-FPh)C(=0)OCH2
G 18-354 2-CF3Ph (3-FPh)C(=0)OCH2
G18-355 2-CF3Ph (4-FPh)C(=0)OCH2
G 18-356 2-CF3Ph (2-CIPh)C(=0)OCH2
G18-357 2-CF3Ph (3-CIPh)C(=0)OCH2
G18-358 2-CF3Ph (4-CIPh)C(=0)OCH2
G18-359 2-CF3Ph (2-BrPh)C(=0)OCH2
G 18-360 2-CF3Ph (3-BrPh)C(=0)OCH2
G 18-404 3-CF3Ph CH3CH2OCH2
G 18-405 3-CF3Ph (CH3)2CHOCH2
G 18-406 3-CF3Ph (CH3)3COCH2
G 18-407 3-CF3Ph (CH3)3CCH20CH2
G 18-408 3-CF3Ph CH3CH2C(CH3)2OCH2
G 18-409 3-CF3Ph (c-hex)OCH2
G18-410 3-CF3Ph PhOCH2
G18-41 1 3-CF3Ph (2-CH3Ph)OCH2
G18-412 3-CF3Ph (3-CH3Ph)OCH2
G18-413 3-CF3Ph (4-CH3Ph)OCH2
G18-414 3-CF3Ph (2-CH3OPh)OCH2
G18-415 3-CF3Ph (3-CH3OPh)OCH2
G18-416 3-CF3Ph (4-CH3OPh)OCH2
G18-417 3-CF3Ph (2-FPh)OCH2
G18-418 3-CF3Ph (3-FPh)OCH2
G18-419 3-CF3Ph (4-FPh)OCH2
G 18-420 3-CF3Ph (2-CIPh)OCH2
G 18-421 3-CF3Ph (3-CIPh)OCH2
G 18-422 3-CF3Ph (4-CIPh)OCH2
G 18-423 3-CF3Ph (2-BrPh)OCH2
G 18-424 3-CF3Ph (3-BrPh)OCH2
G 18-425 3-CF3Ph (4-BrPh)OCH2
G 18-426 3-CF3Ph (2-CF3OPh)OCH2
G 18-427 3-CF3Ph (3-CF3OPh)OCH2
G 18-428 3-CF3Ph (4-CF3OPh)OCH2
G 18-429 3-CF3Ph (2-CNPh)OCH2
G 18-430 3-CF3Ph (3-CNPh)OCH2
G18-431 3-CF3Ph (4-CNPh)OCH2
G 18-432 3-CF3Ph (2-N02Ph)OCH2
G 18-433 3-CF3Ph (3-N02Ph)OCH2
G 18-434 3-CF3Ph (4-N02Ph)OCH2
G 18-435 3-CF3Ph (2-CF3Ph)OCH2
G 18-436 3-CF3Ph (3-CF3Ph)OCH2
G 18-437 3-CF3Ph (4-CF3Ph)OCH2
G 18-438 3-CF3Ph PhCH2OCH2
G 18-439 3-CF3Ph (2-CH3Ph)CH2OCH2
G 18-440 3-CF3Ph (3-CH3Ph)CH2OCH2
G 18-441 3-CF3Ph (4-CH3Ph)CH2OCH2
G 18-442 3-CF3Ph (2-CH3OPh)CH2OCH2
G 18-443 3-CF3Ph (3-CH3OPh)CH2OCH2
G 18-444 3-CF3Ph (4-CH3OPh)CH2OCH2
G 18-445 3-CF3Ph (2-FPh)CH2OCH2
G 18-446 3-CF3Ph (3-FPh)CH2OCH2
G 18-447 3-CF3Ph (4-FPh)CH2OCH2
G 18-448 3-CF3Ph (2-CIPh)CH2OCH2
G 18-449 3-CF3Ph (3-CIPh)CH2OCH2
G 18-450 3-CF3Ph (4-CIPh)CH2OCH2
G18-451 3-CF3Ph (2-BrPh)CH2OCH2
G 18-452 3-CF3Ph (3-BrPh)CH2OCH2
G 18-453 3-CF3Ph (4-BrPh)CH2OCH2
G 18-454 3-CF3Ph (2-CF3OPh)CH2OCH2
G 18-455 3-CF3Ph (3-CF3OPh)CH2OCH2
G 18-456 3-CF3Ph (4-CF3OPh)CH2OCH2
G 18-457 3-CF3Ph (2-CNPh)CH2OCH2
G 18-458 3-CF3Ph (3-CNPh)CH2OCH2
G 18-459 3-CF3Ph (4-CNPh)CH2OCH2
G 18-460 3-CF3Ph (2-N02Ph)CH2OCH2
G 18-461 3-CF3Ph (3-N02Ph)CH2OCH2
G 18-462 3-CF3Ph (4-N02Ph)CH2OCH2
G 18-463 3-CF3Ph (2-CF3Ph)CH2OCH2
G 18-464 3-CF3Ph (3-CF3Ph)CH2OCH2
G 18-465 3-CF3Ph (4-CF3Ph)CH2OCH2
G 18-466 3-CF3Ph CH3C(=0)OCH2
G 18-467 3-CF3Ph CH3CH2C(=0)OCH2
G 18-468 3-CF3Ph CH(CH3)2C(=0)OCH2
G 18-469 3-CF3Ph (CH3)3C(=0)OCH2
G 18-470 3-CF3Ph (CH3)3CCH2(=0)OCH2
G18-471 3-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G 18-472 3-CF3Ph CF3C(=0)OCH2
G 18-473 3-CF3Ph CF3CF2C(=0)OCH2
G 18-474 3-CF3Ph (c-hex)C(=0)OCH2
G 18-475 3-CF3Ph PhC(=0)OCH2
G 18-476 3-CF3Ph (2-CH3Ph)C(=0)OCH2
G 18-477 3-CF3Ph (3-CH3Ph)C(=0)OCH2
G 18-478 3-CF3Ph (4-CH3Ph)C(=0)OCH2
G 18-479 3-CF3Ph (2-CH3OPh)C(=0)OCH2
G 18-480 3-CF3Ph (3-CH3OPh)C(=0)OCH2
G18-481 3-CF3Ph (4-CH3OPh)C(=0)OCH2
G 18-482 3-CF3Ph (2-FPh)C(=0)OCH2
G 18-483 3-CF3Ph (3-FPh)C(=0)OCH2
G 18-484 3-CF3Ph (4-FPh)C(=0)OCH2
G 18-485 3-CF3Ph (2-CIPh)C(=0)OCH2
G 18-486 3-CF3Ph (3-CIPh)C(=0)OCH2
G 18-487 3-CF3Ph (4-CIPh)C(=0)OCH2
G 18-488 3-CF3Ph (2-BrPh)C(=0)OCH2
G 18-489 3-CF3Ph (3-BrPh)C(=0)OCH2
G 18-490 3-CF3Ph (4-BrPh)C(=0)OCH2
G18-491 3-CF3Ph (2-CF3OPh)C(=0)OCH2
G 18-492 3-CF3Ph (3-CF3OPh)C(=0)OCH2
G 18-493 3-CF3Ph (4-CF3OPh)C(=0)OCH2
G 18-494 3-CF3Ph (2-CNPh)C(=0)OCH2
G 18-495 3-CF3Ph (3-CNPh)C(=0)OCH2
G 18-496 3-CF3Ph (4-CNPh)C(=0)OCH2
G 18-497 3-CF3Ph (2-N02Ph)C(=0)OCH2
G 18-498 3-CF3Ph (3-N02Ph)C(=0)OCH2
G 18-542 4-CF3Ph (4-CH3Ph)OCH2
G 18-543 4-CF3Ph (2-CH3OPh)OCH2
G 18-544 4-CF3Ph (3-CH3OPh)OCH2
G 18-545 4-CF3Ph (4-CH3OPh)OCH2
G 18-546 4-CF3Ph (2-FPh)OCH2
G 18-547 4-CF3Ph (3-FPh)OCH2
G 18-548 4-CF3Ph (4-FPh)OCH2
G 18-549 4-CF3Ph (2-CIPh)OCH2
G18-550 4-CF3Ph (3-CIPh)OCH2
G18-551 4-CF3Ph (4-CIPh)OCH2
G 18-552 4-CF3Ph (2-BrPh)OCH2
G18-553 4-CF3Ph (3-BrPh)OCH2
G 18-554 4-CF3Ph (4-BrPh)OCH2
G18-555 4-CF3Ph (2-CF3OPh)OCH2
G 18-556 4-CF3Ph (3-CF3OPh)OCH2
G18-557 4-CF3Ph (4-CF3OPh)OCH2
G18-558 4-CF3Ph (2-CNPh)OCH2
G18-559 4-CF3Ph (3-CNPh)OCH2
G 18-560 4-CF3Ph (4-CNPh)OCH2
G18-561 4-CF3Ph (2-N02Ph)OCH2
G 18-562 4-CF3Ph (3-N02Ph)OCH2
G 18-563 4-CF3Ph (4-N02Ph)OCH2
G 18-564 4-CF3Ph (2-CF3Ph)OCH2
G 18-565 4-CF3Ph (3-CF3Ph)OCH2
G 18-566 4-CF3Ph (4-CF3Ph)OCH2
G 18-567 4-CF3Ph PhCH2OCH2
G 18-568 4-CF3Ph (2-CH3Ph)CH2OCH2
G 18-569 4-CF3Ph (3-CH3Ph)CH2OCH2
G18-570 4-CF3Ph (4-CH3Ph)CH2OCH2
G18-571 4-CF3Ph (2-CH3OPh)CH2OCH2
G 18-572 4-CF3Ph (3-CH3OPh)CH2OCH2
G18-573 4-CF3Ph (4-CH3OPh)CH2OCH2
G 18-574 4-CF3Ph (2-FPh)CH2OCH2
G18-575 4-CF3Ph (3-FPh)CH2OCH2
G 18-576 4-CF3Ph (4-FPh)CH2OCH2
G18-577 4-CF3Ph (2-CIPh)CH2OCH2
G18-578 4-CF3Ph (3-CIPh)CH2OCH2
G18-579 4-CF3Ph (4-CIPh)CH2OCH2
G18-580 4-CF3Ph (2-BrPh)CH2OCH2
G18-581 4-CF3Ph (3-BrPh)CH2OCH2
G 18-582 4-CF3Ph (4-BrPh)CH2OCH2
G18-583 4-CF3Ph (2-CF3OPh)CH2OCH2
G 18-584 4-CF3Ph (3-CF3OPh)CH2OCH2
G18-585 4-CF3Ph (4-CF3OPh)CH2OCH2
G 18-586 4-CF3Ph (2-CNPh)CH2OCH2
G18-587 4-CF3Ph (3-CNPh)CH2OCH2
G18-588 4-CF3Ph (4-CNPh)CH2OCH2
G18-589 4-CF3Ph (2-N02Ph)CH2OCH2
G18-590 4-CF3Ph (3-N02Ph)CH2OCH2
G18-591 4-CF3Ph (4-N02Ph)CH2OCH2
G 18-592 4-CF3Ph (2-CF3Ph)CH2OCH2
G18-593 4-CF3Ph (3-CF3Ph)CH2OCH2
G 18-594 4-CF3Ph (4-CF3Ph)CH2OCH2
G18-595 4-CF3Ph CH3C(=0)OCH2
G 18-596 4-CF3Ph CH3CH2C(=0)OCH2
G18-597 4-CF3Ph CH(CH3)2C(=0)OCH2
G18-598 4-CF3Ph (CH3)3C(=0)OCH2
G18-599 4-CF3Ph (CH3)3CCH2(=0)OCH2
G 18-600 4-CF3Ph CH3CH2C(CH3)2C(=0)OCH2
G18-601 4-CF3Ph CF3C(=0)OCH2
G 18-602 4-CF3Ph CF3CF2C(=0)OCH2
G 18-603 4-CF3Ph (c-hex)C(=0)OCH2
G 18-604 4-CF3Ph PhC(=0)OCH2
G 18-605 4-CF3Ph (2-CH3Ph)C(=0)OCH2
G 18-606 4-CF3Ph (3-CH3Ph)C(=0)OCH2
G 18-607 4-CF3Ph (4-CH3Ph)C(=0)OCH2
G 18-608 4-CF3Ph (2-CH3OPh)C(=0)OCH2
G 18-609 4-CF3Ph (3-CH3OPh)C(=0)OCH2
G18-610 4-CF3Ph (4-CH3OPh)C(=0)OCH2
G18-611 4-CF3Ph (2-FPh)C(=0)OCH2
G18-612 4-CF3Ph (3-FPh)C(=0)OCH2
G18-613 4-CF3Ph (4-FPh)C(=0)OCH2
G18-614 4-CF3Ph (2-CIPh)C(=0)OCH2
G18-615 4-CF3Ph (3-CIPh)C(=0)OCH2
G18-616 4-CF3Ph (4-CIPh)C(=0)OCH2
G18-617 4-CF3Ph (2-BrPh)C(=0)OCH2
G18-618 4-CF3Ph (3-BrPh)C(=0)OCH2
G18-619 4-CF3Ph (4-BrPh)C(=0)OCH2
G 18-620 4-CF3Ph (2-CF3OPh)C(=0)OCH2
G 18-621 4-CF3Ph (3-CF3OPh)C(=0)OCH2
G 18-622 4-CF3Ph (4-CF3OPh)C(=0)OCH2
G 18-623 4-CF3Ph (2-CNPh)C(=0)OCH2
G 18-624 4-CF3Ph (3-CNPh)C(=0)OCH2
G 18-625 4-CF3Ph (4-CNPh)C(=0)OCH2
G 18-626 4-CF3Ph (2-N02Ph)C(=0)OCH2
G 18-627 4-CF3Ph (3-N02Ph)C(=0)OCH2
G 18-628 4-CF3Ph (4-N02Ph)C(=0)OCH2
G 18-629 4-CF3Ph (2-CF3Ph)C(=0)OCH2
G 18-630 4-CF3Ph (3-CF3Ph)C(=0)OCH2
G18-631 4-CF3Ph (4-CF3Ph)C(=0)OCH2
G 18-632 3,5-(CF3)2Ph CH3
G 18-633 3,5-(CF3)2Ph CH3CH2
G 18-634 3,5-(CF3)2Ph CH3CH2CH2
G 18-635 3,5-(CF3)2Ph (CH3)2CH
G 18-636 3,5-(CF3)2Ph CH3C(=0)
G 18-680 3,5-(CF3)2Ph (4-CIPh)OCH2
G18-681 3,5-(CF3)2Ph (2-BrPh)OCH2
G 18-682 3,5-(CF3)2Ph (3-BrPh)OCH2
G 18-683 3,5-(CF3)2Ph (4-BrPh)OCH2
G 18-684 3,5-(CF3)2Ph (2-CF3OPh)OCH2
G 18-685 3,5-(CF3)2Ph (3-CF3OPh)OCH2
G 18-686 3,5-(CF3)2Ph (4-CF3OPh)OCH2
G 18-687 3,5-(CF3)2Ph (2-CNPh)OCH2
G 18-688 3,5-(CF3)2Ph (3-CNPh)OCH2
G 18-689 3,5-(CF3)2Ph (4-CNPh)OCH2
G 18-690 3,5-(CF3)2Ph (2-N02Ph)OCH2
G18-691 3,5-(CF3)2Ph (3-N02Ph)OCH2
G 18-692 3,5-(CF3)2Ph (4-N02Ph)OCH2
G 18-693 3,5-(CF3)2Ph (2-CF3Ph)OCH2
G 18-694 3,5-(CF3)2Ph (3-CF3Ph)OCH2
G 18-695 3,5-(CF3)2Ph (4-CF3Ph)OCH2
G 18-696 3,5-(CF3)2Ph PhCH2OCH2
G 18-697 3,5-(CF3)2Ph (2-CH3Ph)CH2OCH2
G 18-698 3,5-(CF3)2Ph (3-CH3Ph)CH2OCH2
G 18-699 3,5-(CF3)2Ph (4-CH3Ph)CH2OCH2
G18-700 3,5-(CF3)2Ph (2-CH3OPh)CH2OCH2
G18-701 3,5-(CF3)2Ph (3-CH3OPh)CH2OCH2
G 18-702 3,5-(CF3)2Ph (4-CH3OPh)CH2OCH2
G18-703 3,5-(CF3)2Ph (2-FPh)CH2OCH2
G 18-704 3,5-(CF3)2Ph (3-FPh)CH2OCH2
G18-705 3,5-(CF3)2Ph (4-FPh)CH2OCH2
G 18-706 3,5-(CF3)2Ph (2-CIPh)CH2OCH2
G18-707 3,5-(CF3)2Ph (3-CIPh)CH2OCH2
G18-708 3,5-(CF3)2Ph (4-CIPh)CH2OCH2
G18-709 3,5-(CF3)2Ph (2-BrPh)CH2OCH2
G18-710 3,5-(CF3)2Ph (3-BrPh)CH2OCH2
G18-711 3,5-(CF3)2Ph (4-BrPh)CH2OCH2
G18-712 3,5-(CF3)2Ph (2-CF3OPh)CH2OCH2
G18-713 3,5-(CF3)2Ph (3-CF3OPh)CH2OCH2
G18-714 3,5-(CF3)2Ph (4-CF3OPh)CH2OCH2
G18-715 3,5-(CF3)2Ph (2-CNPh)CH2OCH2
G18-716 3,5-(CF3)2Ph (3-CNPh)CH2OCH2
G18-717 3,5-(CF3)2Ph (4-CNPh)CH2OCH2
G18-718 3,5-(CF3)2Ph (2-N02Ph)CH2OCH2
G18-719 3,5-(CF3)2Ph (3-N02Ph)CH2OCH2
G 18-720 3,5-(CF3)2Ph (4-N02Ph)CH2OCH2
G18-721 3,5-(CF3)2Ph (2-CF3Ph)CH2OCH2
G 18-722 3,5-(CF3)2Ph (3-CF3Ph)CH2OCH2
G 18-723 3,5-(CF3)2Ph (4-CF3Ph)CH2OCH2
G 18-724 3,5-(CF3)2Ph CH3C(=0)OCH2
G 18-725 3,5-(CF3)2Ph CH3CH2C(=0)OCH2
G 18-726 3,5-(CF3)2Ph CH(CH3)2C(=0)OCH2
G 18-727 3,5-(CF3)2Ph (CH3)3C(=0)OCH2
G 18-728 3,5-(CF3)2Ph (CH3)3CCH2(=0)OCH2
G 18-729 3,5-(CF3)2Ph CH3CH2C(CH3)2C(=0)OCH2
G18-730 3,5-(CF3)2Ph CF3C(=0)OCH2
G18-731 3,5-(CF3)2Ph CF3CF2C(=0)OCH2
G 18-732 3,5-(CF3)2Ph (c-hex)C(=0)OCH2
G18-733 3,5-(CF3)2Ph PhC(=0)OCH2
G 18-734 3,5-(CF3)2Ph (2-CH3Ph)C(=0)OCH2
G18-735 3,5-(CF3)2Ph (3-CH3Ph)C(=0)OCH2
G 18-736 3,5-(CF3)2Ph (4-CH3Ph)C(=0)OCH2
G18-737 3,5-(CF3)2Ph (2-CH3OPh)C(=0)OCH2
G18-738 3,5-(CF3)2Ph (3-CH3OPh)C(=0)OCH2
G18-739 3,5-(CF3)2Ph (4-CH3OPh)C(=0)OCH2
G 18-740 3,5-(CF3)2Ph (2-FPh)C(=0)OCH2
G18-741 3,5-(CF3)2Ph (3-FPh)C(=0)OCH2
G 18-742 3,5-(CF3)2Ph (4-FPh)C(=0)OCH2
G 18-743 3,5-(CF3)2Ph (2-CIPh)C(=0)OCH2
G 18-744 3,5-(CF3)2Ph (3-CIPh)C(=0)OCH2
G 18-745 3,5-(CF3)2Ph (4-CIPh)C(=0)OCH2
G 18-746 3,5-(CF3)2Ph (2-BrPh)C(=0)OCH2
G 18-747 3,5-(CF3)2Ph (3-BrPh)C(=0)OCH2
G 18-748 3,5-(CF3)2Ph (4-BrPh)C(=0)OCH2
G 18-749 3,5-(CF3)2Ph (2-CF3OPh)C(=0)OCH2
G18-750 3,5-(CF3)2Ph (3-CF3OPh)C(=0)OCH2
G18-751 3,5-(CF3)2Ph (4-CF3OPh)C(=0)OCH2
G 18-752 3,5-(CF3)2Ph (2-CNPh)C(=0)OCH2
G18-753 3,5-(CF3)2Ph (3-CNPh)C(=0)OCH2
G 18-754 3,5-(CF3)2Ph (4-CNPh)C(=0)OCH2
G18-755 3,5-(CF3)2Ph (2-N02Ph)C(=0)OCH2
G 18-756 3,5-(CF3)2Ph (3-N02Ph)C(=0)OCH2
G18-757 3,5-(CF3)2Ph (4-N02Ph)C(=0)OCH2
G18-758 3,5-(CF3)2Ph (2-CF3Ph)C(=0)OCH2
G18-759 3,5-(CF3)2Ph (3-CF3Ph)C(=0)OCH2
G 18-760 3,5-(CF3)2Ph (4-CF3Ph)C(=0)OCH2
[0309] Table 10
G16-1 H-NMR (DMSO-d6) δ: 8.78 (1 H, s)
G18-1 H-NMR (DMSO-d6) δ: 8.88 (1 H, s)
[0310] A novel insecticidal oxadiazolinone derivative of the present invention usually has high activity and exhibits safety. Furthermore, the oxadiazolinone derivative of the present invention is highly environmentally safe because of being degraded in the natural world and is exceedingly useful as an insecticide and the like.
Claims
1. An oxadiazolinone derivative represented by the formula (I):
wherein
G represents a 5- or 6-membered heterocyclic ring containing at least one of oxygen, nitrogen and sulfur atoms, and the heterocyclic ring may be substituted by R3, with the proviso that when G represents a pyridine ring substituted by R3 and when the nitrogen atom in the pyridine ring is at an ortho position relative to the carbon atom bonded to the oxadiazolinone ring, the positions of the carbon atom bonded to R1 and the carbon atom bonded to R3 are each limited to any position selected from the ortho and meta positions relative to this nitrogen atom;
R3 represents hydrogen, halogen, nitro, cyano, CM2 alkyl, CM2 haloalkyi, CM2 alkoxy, Ci-12 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, Ci-12 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy, mercapto or C3.8 cycloalkyl;
X represents an oxygen or sulfur atom;
R1 represents CM2 haloalkyi, CM2 haloalkoxy, CM2 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_i2 alkyl)amino, phenyl- Ci-12 alkoxy, phenyl-Ci_i2 alkylsulfenyl, phenyl-Ci_i2 alkylsulfinyl, phenyl-Ci_i2 alkylsulfonyl, phenyl-Ci_i2 alkylamino, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM 2
haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, CM2 alkylsulfinyl-Ci-i2 alkyl, Ci. 12 alkylsulfonyl-Ci-12 alkyl, CM2 haloalkylsulfenyl-Ci-i2 alkyl, CM2 haloalkylsulfinyl-Ci-i2 alkyl, Ci- 12 haloalkylsulfonyl-Ci-i2 alkyl, C2-12 alkenyloxy, C2-12 haloalkenyloxy, C2-12 alkynyloxy, C2-12 haloalkynyloxy, (CM2 alkyl)3 silyloxy or hydroxy, and these substituents can be optionally substituted by a substituent(s) selected from halogen, cyano, amino, mercapto, CM2 alkyl, Ci- 12 haloalkyi, CM2 haloalkoxy, C2-12 alkenyloxy, C2-12 haloalkenyloxy, C2-12 alkynyloxy, C2-12 haloalkynyloxy, CM2 alkylsulfenyl-Ci-12 alkyl and hydroxy; and
R2 represents hydrogen, -CH2CN, CM2 alkyl, CM2 haloalkyi, C3.8 cycloalkyl which may be optionally substituted by a substituent(s) selected from halogen, CM2 alkyl and CM 2 haloalkyi, benzyl which may be optionally substituted by a substituent selected from halogen, cyano, nitro, Ci_3 alkyl, Ci_3 haloalkyl and Ci_3 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
wherein, in each of the formulas Q1 to Q5,
a bond marked with * represents a bond with the nitrogen atom bonded to R2 in the formula (I);
R21 represents hydrogen, CM2 alkyl, CM2 haloalkyl or C3.8 cycloalkyl;
R22 and R23 individually represent hydrogen, CM2 alkyl, CM2 haloalkyl, CM2 alkoxy, C3.8 cycloalkyl, C2_i2 alkenyloxy or C2_i2 alkynyloxy, or R22 and R23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring may be substituted by a substituent(s) selected from halogen, CM2 alkyl, CM2 haloalkyl, nitro, CM2 alkoxy, cyano, CM2 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy and mercapto;
R24 and R25 individually represent a substituent selected from CM2 alkyl, CM2 haloalkyl, C3-8 cycloalkyl, phenyl and phenyl-Ci_3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, CM2 alkyl, CM2 haloalkyl, nitro, CM2 alkoxy, cyano, CM2 haloalkoxy, CM2 alkylsulfenyl, CM2 alkylsulfinyl, CM2 alkylsulfonyl, CM2 haloalkylsulfenyl, CM2 haloalkylsulfinyl, CM2 haloalkylsulfonyl, hydroxy and mercapto; and
R26 represents a hydrogen atom or CM2 alkyl.
2. The oxadiazolinone derivative according to claim 1 , wherein when the heterocyclic ring constituting G is substituted by R3,
R3 represents hydrogen, halogen, nitro, cyano, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 alkoxy, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy, mercapto or C3.7 cycloalkyl;
X represents an oxygen or sulfur atom;
R1 represents Ci_6 haloalkyl, Ci_6 haloalkoxy, Ci_6 alkoxy, phenyl, phenoxy, pyridyl, phenylsulfenyl, phenylsulfinyl, phenylsulfonyl, phenylamino, (phenyl)(Ci_6 alkyl)amino, phenyl- Ci-3 alkoxy, phenyl-Ci_3 alkylsulfenyl, phenyl-Ci_3 alkylsulfinyl, phenyl-Ci_3 alkylsulfonyl, phenyl- Ci-3 alkylamino, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, Ci_6 alkylsulfinyl-Ci-3 alkyl, Ci_6 alkylsulfonyl-Ci_3 alkyl, Ci-6 haloalkylsulfenyl-Ci_3 alkyl, Ci_6 haloalkylsulfinyl-Ci-3 alkyl, Ci_6 haloalkylsulfonyl-Ci_3 alkyl, C2-6 alkenyloxy, C2-6 haloalkenyloxy, C2-6 alkynyloxy, C2-6 haloalkynyloxy, (Ci_6 alkyl)3 silyloxy or hydroxy, and these substituents can be optionally substituted by a substituent(s) selected from halogen, cyano, amino, mercapto, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 haloalkoxy, C2-6 alkenyloxy, C2. 6 haloalkenyloxy, C2.6 alkynyloxy, C2.6 haloalkynyloxy, Ci_6 alkylsulfenyl-Ci.3 alkyl and hydroxy; and
R2 represents hydrogen, -CH2CN, Ci_6 alkyl, Ci_6 haloalkyl, C3.6 cycloalkyl optionally substituted by a substituent selected from halogen, Ci_6 alkyl and Ci_6 haloalkyl, benzyl optionally substituted by a substituent selected from halogen, cyano, nitro, Ci_6 alkyl, Ci_6 haloalkyl and Ci_6 alkoxy or a substituent represented by one selected from the following formulas Q1 , Q2, Q3, Q4, and Q5:
Q 1 Q 2 Q 3 Q 4 Q 5
wherein, in each of the formulas Q1 to Q5,
a bond marked with * represents a bond with the nitrogen atom bonded to R2 in the formula (I);
R21 represents hydrogen, Ci_6 alkyl, Ci_6 haloalkyl or C3.6 cycloalkyl;
R22 and R23 individually represent hydrogen, Ci_6 alkyl, Ci_6 haloalkyl, Ci_6 alkoxy, C3.7 cycloalkyl, C2.6 alkenyloxy or C2.6 alkynyloxy, or R22 and R23 form a 3- to 8-membered heterocyclic ring together with the nitrogen atom bonded thereto, and the heterocyclic ring can be optionally substituted by a substituent selected from halogen, Ci_6 alkyl, Ci_6 haloalkyl, nitro, C1-6 alkoxy, cyano, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy and mercapto;
R24 and R25 individually represent a substituent selected from Ci_6 alkyl, Ci_6 haloalkyl, C3.7 cycloalkyl, phenyl and phenyl-Ci_3 alkyl, and these substituents can be optionally substituted by a substituent(s) selected from halogen, Ci_6 alkyl, Ci_6 haloalkyl, nitro, Ci_6 alkoxy, cyano, Ci_6 haloalkoxy, Ci_6 alkylsulfenyl, Ci_6 alkylsulfinyl, Ci_6 alkylsulfonyl, Ci_6 haloalkylsulfenyl, Ci_6 haloalkylsulfinyl, Ci_6 haloalkylsulfonyl, hydroxy and mercapto; and
R26 represents a hydrogen atom or Ci_6 alkyl.
3. An insecticide containing the oxadiazolinone derivative according to claim 1 or 2 as an active ingredient.
4. An animal parasite control agent containing the oxadiazolinone derivative according to claim 1 or 2 as an active ingredient.
5. Use of an oxadiazolinone derivative according to claim 1 or 2 as an insecticide.
6. Use of an oxadiazolinone derivative according to claim 1 or 2 for combating aphids and/or mites.
7. A seed coated with an oxadiazolinone derivative according to claim 1 or 2.
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KR20170040243A (en) * | 2014-08-13 | 2017-04-12 | 닛뽕소다 가부시키가이샤 | Diaryl imidazole compound and pest control agent |
CN107108492A (en) * | 2014-12-24 | 2017-08-29 | 北京生命科学研究所 | Inhibitor of cellular necrosis |
WO2018185187A1 (en) | 2017-04-05 | 2018-10-11 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
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