WO2012023873A1 - Combination of vitamins and minerals - Google Patents

Combination of vitamins and minerals Download PDF

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Publication number
WO2012023873A1
WO2012023873A1 PCT/RO2011/000012 RO2011000012W WO2012023873A1 WO 2012023873 A1 WO2012023873 A1 WO 2012023873A1 RO 2011000012 W RO2011000012 W RO 2011000012W WO 2012023873 A1 WO2012023873 A1 WO 2012023873A1
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
mixture
nutritional supplement
excipients
vitamins
Prior art date
Application number
PCT/RO2011/000012
Other languages
French (fr)
Inventor
Paula Soroceanu
Original Assignee
S.C. Biofarm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S.C. Biofarm S.A. filed Critical S.C. Biofarm S.A.
Publication of WO2012023873A1 publication Critical patent/WO2012023873A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a nutritional supplement composition which contains a mixture of vitamins and minerals incorporated in a fatty base, accompanied by various flavoring agents and presented as chewable tablets for oral intake, and the method of producing the nutritional supplement composition.
  • the invention has applicability in the pharmaceutical field.
  • the invention solves the problem of preparing a nutritional supplement containing a vitamin and mineral complex as chewable tablets, easy to dose and with pleasant tasting, unlike other currently used products that present themselves as hard tablets, coated tablets or capsules.
  • the composition is also well tolerated by children and adolescents, being presented in an attractive form With various flavors such as (but not limited to) chocolate, vanilla or apricot.
  • the formula for one chewable tablet contains: Vitamin A (retinol acetate 1500000 IU/g): between 6 ⁇ g and 1275 g; Vitamin C (ascorbic acid): between 0.4 mg and 210 mg; Vitamin E (alpha-tocophery acetate): between 0.07 ⁇ g and 15 ⁇ g; Vitamin Bi (thiamin chlorhydrate): between 0.01 1 mg and 4.8 mg; Vitamin B 2 (riboflavin): between 0.01 and 4.8 mg; Vitamin B 6 (pyridoxine chlorhydrate): between 0.012 mg and 6 mg; Vitamin D 2 (40000 IU/mg) (ergocalciferol): between 0.05 ⁇ g and 22.5 ⁇ g; Vitamin PP (nicotinic acid): between 0.16 mg and 54 mg; Calcium gluconate: between 13 mg and 3900 mg; Calcium pantotenat: 10 mg; Excipients (up to 5600 mg): fatty base (hydrogenated vegetable fat, such as 100% refined and hydrogenated palm kernel oil), vanill
  • Lutein between 0.1 mg and 2 mg
  • Echinacea between 0.5 g and 3 g
  • Vitamin H (Biotin) between 0.25 ⁇ g and 105 ⁇ g
  • Folic acid between 4 ⁇ g and 1500
  • This formula of nutritional supplement targets children and adolescents, adults, the elderly (above 65 years of age), pregnant and nursing women.
  • Vitamin and mineral dosage can be adapted to specifically match the needs of every target category.
  • the first step is to melt the fatty base: the necessary quantity of fatty base is minced and melted in the duplicator at 35 - 37°C.
  • the second step consists of preparing the vitamin powder mixture.
  • the necessary quantities of liposoluble vitamins (vitamins A, D 2 , and E) are successively homogenized in a portion of molten fatty base.
  • Calcium gluconate powder, powdered sugar and powdered milk are placed in a blending machine called "malaxator" along with vitamins B 2 , B 6 , C, nicotinic acid, calcium pantotenat, vanillin and chocolate/ vanilla/apricot flavors etc. and are homogenized for 10 - 15 minutes.
  • the liposoluble vitamins and fatty base mixture is then added to the powder mixture and is homogenized for 10 - 15 minutes.
  • the mixture is put through a roller mixer having 3 rolls, setting the distance between the rolls so as to obtain homogenous paste layers.
  • the paste obtained with the roller mixer is returned to the malaxator.
  • the remaining melted fatty based is added to the mix in successive portions and homogenized for approximately 15 - 20 minutes.
  • the paste is transferred from the malaxator to a storage vessel using a transvasation pump. Inside the storage vessel, this first lot of paste will be homogenized with a second lot of paste (prepared following the same steps described above), for 20 - 30 minutes, at a temperature of 35 - 37°C.
  • the paste obtained by homogenizing the two lots is then passed to the feeding container of the tablet molding device.
  • the device can be set to mold 5 tablets into one aluminum or opaque PVC blister package.
  • the resulting blister packs go through a cooling tunnel, where they stay for 8— 10 minutes at a temperature of 2 - 8°C. After the cooling, the blister packs are moved to the " packaging machine.
  • the nutritional supplement according to the invention has the following advantages: it is easy to administer as it is comprised of chewable tablets obtained by incorporating vitamins and minerals into a fatty base, along with other excipients such as powdered milk and powdered sugar;
  • the product has an innovative presentation and a very pleasant taste, similar to a dessert, the consumer being protected from the unpleasant taste and smell of certain vitamins and minerals;
  • incorporation within a fatty base allows for an easy absorption of vitamins and minerals by the human body;
  • the product is recommended for supplementing an unbalanced diet, loss of appetite, periods of intense physical or intellectual effort (the composition that also contains lecithin), convalescence, excessive tiredness, maintaining a healthy retina (the composition that also contains lutein), strengthening the immune system (the composition that also contains Echinacea) and maintaining a general state of good health.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a nutritional supplement composition presented as chewable tablets and to the method by which it is obtained. The nutritional supplement, according to the invention, contains a mixture of vitamins A, C, B1, B2, B6, D2, H, PP, calcium in the form of gluconate and pantotenat, folic acid, lutein, Echinacea, soy lecithin mixed with a fatty base such as hydrogenated vegetable oil and excipients such as powdered milk, powdered sugar, flavoring agents. The method, according to the invention, consists of successively incorporating the powdered components into a portion of melted fatty base during continuous homogenization, followed by the passage of the mixture through a rolling device, producing an homogenous paste which is then mixed with the remaining melted fatty base and homogenized for 25... 30 minutes at a temperature of 35... 37 °C; the mixture is then placed in a tablet molding device.

Description

COMBINATION OF VITAMINS AND MINERALS
The present invention relates to a nutritional supplement composition which contains a mixture of vitamins and minerals incorporated in a fatty base, accompanied by various flavoring agents and presented as chewable tablets for oral intake, and the method of producing the nutritional supplement composition.
The invention has applicability in the pharmaceutical field.
There are known medicinal compositions containing vitamins A, Bj, B2, calcium pantotenat (RO 77096), vitamin mixtures as molded tablets containing vitamins C, Bl5 B2, D2 (RO 91976) and medicinal compositions in the form of capsules containing vitamins A, C, Bj, B2, B6, B12, D3, E, Ki (RO 118178 B).
The invention solves the problem of preparing a nutritional supplement containing a vitamin and mineral complex as chewable tablets, easy to dose and with pleasant tasting, unlike other currently used products that present themselves as hard tablets, coated tablets or capsules. The composition is also well tolerated by children and adolescents, being presented in an attractive form With various flavors such as (but not limited to) chocolate, vanilla or apricot.
The formula for one chewable tablet contains: Vitamin A (retinol acetate 1500000 IU/g): between 6 μg and 1275 g; Vitamin C (ascorbic acid): between 0.4 mg and 210 mg; Vitamin E (alpha-tocophery acetate): between 0.07 μg and 15 μg; Vitamin Bi (thiamin chlorhydrate): between 0.01 1 mg and 4.8 mg; Vitamin B2 (riboflavin): between 0.01 and 4.8 mg; Vitamin B6 (pyridoxine chlorhydrate): between 0.012 mg and 6 mg; Vitamin D2 (40000 IU/mg) (ergocalciferol): between 0.05 μg and 22.5 μg; Vitamin PP (nicotinic acid): between 0.16 mg and 54 mg; Calcium gluconate: between 13 mg and 3900 mg; Calcium pantotenat: 10 mg; Excipients (up to 5600 mg): fatty base (hydrogenated vegetable fat, such as 100% refined and hydrogenated palm kernel oil), vanillin, powdered milk, powdered sugar, chocolate/ vanilla/ apricot flavor, natural beta carotene extract, etc.
The following components may be alternatively added to the aforementioned basic composition: Lutein between 0.1 mg and 2 mg; Echinacea between 0.5 g and 3 g, Soy lecithin 250 mg, Vitamin H (Biotin) between 0.25 μg and 105 μg or Folic acid between 4 μg and 1500
This formula of nutritional supplement targets children and adolescents, adults, the elderly (above 65 years of age), pregnant and nursing women. Vitamin and mineral dosage can be adapted to specifically match the needs of every target category.
Here follows an example of the producing method of the invention.
The first step is to melt the fatty base: the necessary quantity of fatty base is minced and melted in the duplicator at 35 - 37°C.
The second step consists of preparing the vitamin powder mixture. The necessary quantities of liposoluble vitamins (vitamins A, D2, and E) are successively homogenized in a portion of molten fatty base. Calcium gluconate powder, powdered sugar and powdered milk are placed in a blending machine called "malaxator" along with vitamins B2, B6, C, nicotinic acid, calcium pantotenat, vanillin and chocolate/ vanilla/apricot flavors etc. and are homogenized for 10 - 15 minutes. The liposoluble vitamins and fatty base mixture is then added to the powder mixture and is homogenized for 10 - 15 minutes.
During the third step the mixture is put through a roller mixer having 3 rolls, setting the distance between the rolls so as to obtain homogenous paste layers.
As a final step, the paste obtained with the roller mixer is returned to the malaxator. The remaining melted fatty based is added to the mix in successive portions and homogenized for approximately 15 - 20 minutes. Then the paste is transferred from the malaxator to a storage vessel using a transvasation pump. Inside the storage vessel, this first lot of paste will be homogenized with a second lot of paste (prepared following the same steps described above), for 20 - 30 minutes, at a temperature of 35 - 37°C.
The paste obtained by homogenizing the two lots is then passed to the feeding container of the tablet molding device. The device can be set to mold 5 tablets into one aluminum or opaque PVC blister package.
The resulting blister packs go through a cooling tunnel, where they stay for 8— 10 minutes at a temperature of 2 - 8°C. After the cooling, the blister packs are moved to the "packaging machine.
The nutritional supplement according to the invention has the following advantages: it is easy to administer as it is comprised of chewable tablets obtained by incorporating vitamins and minerals into a fatty base, along with other excipients such as powdered milk and powdered sugar;
- the product has an innovative presentation and a very pleasant taste, similar to a dessert, the consumer being protected from the unpleasant taste and smell of certain vitamins and minerals;
- incorporation within a fatty base (hydrogenated vegetable oils) maintains all chemical properties of vitamins and minerals; ,
incorporation within a fatty base (hydrogenated vegetable oils) allows for an easy absorption of vitamins and minerals by the human body;
- the product is recommended for supplementing an unbalanced diet, loss of appetite, periods of intense physical or intellectual effort (the composition that also contains lecithin), convalescence, excessive tiredness, maintaining a healthy retina (the composition that also contains lutein), strengthening the immune system (the composition that also contains Echinacea) and maintaining a general state of good health.

Claims

1. Nutritional supplement composition containing a mixture of vitamins and minerals, comprising the following formula: 6 μg ... 1275 μg Vitamin A (retinol acetate 1500000 IU/g); 0.4 mg ... 210 mg Vitamin C (ascorbic acid); 0.07 μg ... 15 μg Vitamin E (alpha-tocopheryl acetate); 0.011 mg ... 4.8 mg Vitamin B1 (thiamin chlorhydrate); 0.01 ... 4.8 mg Vitamin B2 (riboflavin); 0.012 mg ... 6 mg Vitamin B6 (pyridoxine chlorhydrate); 0.05 μg ... 22.5 μg Vitamin D2 (40000 IU/mg) (ergocalciferol); 0.16 mg ... 54 mg Vitamin PP (nicotinic acid); 13 mg ... 3900 mg Calcium gluconate; 10 mg Calcium pantotenat; up to 5600 mg excipients : fatty base (hydrogenated vegetable fat, such as 100% refined and hydrogenated palm kernel oil), vanillin, powdered milk, powdered sugar, chocolate/ vanilla/ apricot flavor, natural beta carotene extract, etc., conditioned as chewable tablets and intended for oral administration.
2. Nutritional supplement composition according to Claim 1, wherein 0.1 mg ... 2 mg Lutein are added before the completion with excipients.
3. Nutritional supplement composition according to Claim 1, wherein 0.5 ... 3g Echinacea are added before the completion with excipients.
4. Nutritional supplement composition according to Claim 1, wherein 250 mg Lecithin are added before the completion with excipients.
5. Nutritional supplement composition according to Claim 1, wherein 0.25 μg ...105 μg Vitamin H (Biotin) are added before before the completion with excipients.
6. Nutritional supplement composition according to Claim 1, wherein 4 μg ...1500 |ig Folic acid are added before the completion with excipients.
7. A method of production of the nutritional supplements defined by Claims 1 - 6, comprising the following steps: first mincing the necessary quantity of fatty base, which is then melted in the duplicator at a temperature of 35 - 37 °C; the vitamin powder mixture is prepared next, successively homogenizing the necessary quantities of liposoluble vitamins (vitamins A, D2 and E) in a portion of fatty base; then the powdered calcium gluconate, powdered sugar and powdered milk are homogenized in the malaxator for 10 - 15 minutes along with vitamin Bi, vitamin B2, vitamin B6, nicotinic acid, vitamin C, calcium pantotenat, vanillin, chocolate/ vanilla/ apricot flavors etc.; the mixture of liposoluble vitamins and fatty base is then added to the powder mixture and the resulting mixture is passed through a roller mixer having 3 rolls, setting the distance between rolls so as to produce homogenous paste layers, after which the resulting paste is returned to the malaxator and the remaining melted fatty base is added in successive portions; this mixture is homogenized for 15 - 20 minutes; the resulting paste is then transferred from the malaxator to a storing vessel using a transvasation pump, where it will be mixed and homogenized for 25 - 30 minutes at a temperature of 35 - 37 °C with a second lot of paste obtained through the aforementioned procedure; the resulting paste is transferred to the feeding vessel of the tablet molding device and the resulting blister packs are put through the cooling tunnel for 8 - 10 minutes at a temperature of 2 - 8 °C.
PCT/RO2011/000012 2010-04-01 2011-03-31 Combination of vitamins and minerals WO2012023873A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ROA201000299 2010-04-01
ROA201000299A RO125888B1 (en) 2010-04-01 2010-04-01 Process for preparing a food supplement with vitamins and minerals in a fat base

Publications (1)

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WO2012023873A1 true WO2012023873A1 (en) 2012-02-23

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3323296A1 (en) * 2016-11-16 2018-05-23 Maresol GmbH & Co. KG Chocolate with added nutrients and method for producing a chocolate
WO2019060510A1 (en) * 2017-09-22 2019-03-28 Nutrivida, Llc Oral supplement
WO2020052742A1 (en) * 2018-09-11 2020-03-19 Parapharm Development Limited Capsule, tablet or pill

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO91976A2 (en) * 1985-07-12 1987-06-30 Intreprinderea De Medicamente"Biofarm",Ro VITAMIN MEDICAL COMPOSITION IN THE FORM OF TURNED TABLETS
US6340471B1 (en) * 1999-12-30 2002-01-22 Alvin Kershman Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US20030138484A1 (en) * 2001-10-23 2003-07-24 Boehringer Ingelheim International Gmbh Chewable tablet containing lysine
US20030206948A1 (en) * 1997-07-10 2003-11-06 Gerhard Gergely Soluble, gum-containing, coated chewable tablet
US20060246116A1 (en) * 2003-07-18 2006-11-02 Petworks, Llc Formula and method for the delivery of medications to animals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO91976A2 (en) * 1985-07-12 1987-06-30 Intreprinderea De Medicamente"Biofarm",Ro VITAMIN MEDICAL COMPOSITION IN THE FORM OF TURNED TABLETS
US20030206948A1 (en) * 1997-07-10 2003-11-06 Gerhard Gergely Soluble, gum-containing, coated chewable tablet
US6340471B1 (en) * 1999-12-30 2002-01-22 Alvin Kershman Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US20030138484A1 (en) * 2001-10-23 2003-07-24 Boehringer Ingelheim International Gmbh Chewable tablet containing lysine
US20060246116A1 (en) * 2003-07-18 2006-11-02 Petworks, Llc Formula and method for the delivery of medications to animals

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3323296A1 (en) * 2016-11-16 2018-05-23 Maresol GmbH & Co. KG Chocolate with added nutrients and method for producing a chocolate
WO2019060510A1 (en) * 2017-09-22 2019-03-28 Nutrivida, Llc Oral supplement
WO2020052742A1 (en) * 2018-09-11 2020-03-19 Parapharm Development Limited Capsule, tablet or pill

Also Published As

Publication number Publication date
RO125888A0 (en) 2010-12-30
RO125888B1 (en) 2015-07-30

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