WO2012023873A1 - Combination of vitamins and minerals - Google Patents
Combination of vitamins and minerals Download PDFInfo
- Publication number
- WO2012023873A1 WO2012023873A1 PCT/RO2011/000012 RO2011000012W WO2012023873A1 WO 2012023873 A1 WO2012023873 A1 WO 2012023873A1 RO 2011000012 W RO2011000012 W RO 2011000012W WO 2012023873 A1 WO2012023873 A1 WO 2012023873A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vitamin
- mixture
- nutritional supplement
- excipients
- vitamins
- Prior art date
Links
- 229940088594 vitamin Drugs 0.000 title claims description 17
- 229930003231 vitamin Natural products 0.000 title claims description 17
- 235000013343 vitamin Nutrition 0.000 title claims description 17
- 239000011782 vitamin Substances 0.000 title claims description 17
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims description 10
- 239000011707 mineral Substances 0.000 title claims description 10
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 9
- 239000000796 flavoring agent Substances 0.000 claims abstract description 7
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 7
- 239000011719 vitamin A Substances 0.000 claims abstract description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000011575 calcium Substances 0.000 claims abstract description 6
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 6
- 239000007910 chewable tablet Substances 0.000 claims abstract description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- 235000008476 powdered milk Nutrition 0.000 claims abstract description 6
- 239000003826 tablet Substances 0.000 claims abstract description 6
- 235000014134 echinacea Nutrition 0.000 claims abstract description 4
- 235000012680 lutein Nutrition 0.000 claims abstract description 4
- 239000001656 lutein Substances 0.000 claims abstract description 4
- 229960005375 lutein Drugs 0.000 claims abstract description 4
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims abstract description 4
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims abstract description 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims abstract description 4
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims abstract description 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229960000304 folic acid Drugs 0.000 claims abstract description 3
- 235000019152 folic acid Nutrition 0.000 claims abstract description 3
- 239000011724 folic acid Substances 0.000 claims abstract description 3
- 238000000465 moulding Methods 0.000 claims abstract description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 9
- 235000010755 mineral Nutrition 0.000 claims description 9
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 8
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- 244000018633 Prunus armeniaca Species 0.000 claims description 5
- 235000009827 Prunus armeniaca Nutrition 0.000 claims description 5
- 244000299461 Theobroma cacao Species 0.000 claims description 5
- 244000290333 Vanilla fragrans Species 0.000 claims description 5
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 5
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims description 5
- 229960005069 calcium Drugs 0.000 claims description 5
- 235000001465 calcium Nutrition 0.000 claims description 5
- 235000019219 chocolate Nutrition 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 5
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 229960004494 calcium gluconate Drugs 0.000 claims description 4
- 239000004227 calcium gluconate Substances 0.000 claims description 4
- 235000013927 calcium gluconate Nutrition 0.000 claims description 4
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 4
- 239000011664 nicotinic acid Substances 0.000 claims description 4
- 235000001968 nicotinic acid Nutrition 0.000 claims description 4
- 229960003512 nicotinic acid Drugs 0.000 claims description 4
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 4
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 4
- 235000012141 vanillin Nutrition 0.000 claims description 4
- 239000011716 vitamin B2 Substances 0.000 claims description 4
- 239000011653 vitamin D2 Substances 0.000 claims description 4
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 4
- 244000133098 Echinacea angustifolia Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000011726 vitamin B6 Substances 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- PYASDJRYVQOSJZ-UHFFFAOYSA-N 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hypochlorous acid Chemical compound ClO.CC1=NC=C(CO)C(CO)=C1O PYASDJRYVQOSJZ-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- 229930003756 Vitamin B7 Natural products 0.000 claims description 2
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
- 235000013734 beta-carotene Nutrition 0.000 claims description 2
- 239000011648 beta-carotene Substances 0.000 claims description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 2
- 229960002747 betacarotene Drugs 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 229960002061 ergocalciferol Drugs 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019866 hydrogenated palm kernel oil Nutrition 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229960000342 retinol acetate Drugs 0.000 claims description 2
- 235000019173 retinyl acetate Nutrition 0.000 claims description 2
- 239000011770 retinyl acetate Substances 0.000 claims description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 2
- 235000019192 riboflavin Nutrition 0.000 claims description 2
- 239000002151 riboflavin Substances 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 235000019157 thiamine Nutrition 0.000 claims description 2
- 239000011721 thiamine Substances 0.000 claims description 2
- 235000019871 vegetable fat Nutrition 0.000 claims description 2
- 239000011708 vitamin B3 Substances 0.000 claims description 2
- 235000019160 vitamin B3 Nutrition 0.000 claims description 2
- 239000011735 vitamin B7 Substances 0.000 claims description 2
- 235000011912 vitamin B7 Nutrition 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 235000001892 vitamin D2 Nutrition 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011691 vitamin B1 Substances 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 abstract description 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 abstract description 2
- 235000013355 food flavoring agent Nutrition 0.000 abstract description 2
- 239000008347 soybean phospholipid Substances 0.000 abstract description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 abstract 1
- 241000258180 Echinacea <Echinodermata> Species 0.000 abstract 1
- 229940050410 gluconate Drugs 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 238000005096 rolling process Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 208000034657 Convalescence Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 235000021185 dessert Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a nutritional supplement composition which contains a mixture of vitamins and minerals incorporated in a fatty base, accompanied by various flavoring agents and presented as chewable tablets for oral intake, and the method of producing the nutritional supplement composition.
- the invention has applicability in the pharmaceutical field.
- the invention solves the problem of preparing a nutritional supplement containing a vitamin and mineral complex as chewable tablets, easy to dose and with pleasant tasting, unlike other currently used products that present themselves as hard tablets, coated tablets or capsules.
- the composition is also well tolerated by children and adolescents, being presented in an attractive form With various flavors such as (but not limited to) chocolate, vanilla or apricot.
- the formula for one chewable tablet contains: Vitamin A (retinol acetate 1500000 IU/g): between 6 ⁇ g and 1275 g; Vitamin C (ascorbic acid): between 0.4 mg and 210 mg; Vitamin E (alpha-tocophery acetate): between 0.07 ⁇ g and 15 ⁇ g; Vitamin Bi (thiamin chlorhydrate): between 0.01 1 mg and 4.8 mg; Vitamin B 2 (riboflavin): between 0.01 and 4.8 mg; Vitamin B 6 (pyridoxine chlorhydrate): between 0.012 mg and 6 mg; Vitamin D 2 (40000 IU/mg) (ergocalciferol): between 0.05 ⁇ g and 22.5 ⁇ g; Vitamin PP (nicotinic acid): between 0.16 mg and 54 mg; Calcium gluconate: between 13 mg and 3900 mg; Calcium pantotenat: 10 mg; Excipients (up to 5600 mg): fatty base (hydrogenated vegetable fat, such as 100% refined and hydrogenated palm kernel oil), vanill
- Lutein between 0.1 mg and 2 mg
- Echinacea between 0.5 g and 3 g
- Vitamin H (Biotin) between 0.25 ⁇ g and 105 ⁇ g
- Folic acid between 4 ⁇ g and 1500
- This formula of nutritional supplement targets children and adolescents, adults, the elderly (above 65 years of age), pregnant and nursing women.
- Vitamin and mineral dosage can be adapted to specifically match the needs of every target category.
- the first step is to melt the fatty base: the necessary quantity of fatty base is minced and melted in the duplicator at 35 - 37°C.
- the second step consists of preparing the vitamin powder mixture.
- the necessary quantities of liposoluble vitamins (vitamins A, D 2 , and E) are successively homogenized in a portion of molten fatty base.
- Calcium gluconate powder, powdered sugar and powdered milk are placed in a blending machine called "malaxator" along with vitamins B 2 , B 6 , C, nicotinic acid, calcium pantotenat, vanillin and chocolate/ vanilla/apricot flavors etc. and are homogenized for 10 - 15 minutes.
- the liposoluble vitamins and fatty base mixture is then added to the powder mixture and is homogenized for 10 - 15 minutes.
- the mixture is put through a roller mixer having 3 rolls, setting the distance between the rolls so as to obtain homogenous paste layers.
- the paste obtained with the roller mixer is returned to the malaxator.
- the remaining melted fatty based is added to the mix in successive portions and homogenized for approximately 15 - 20 minutes.
- the paste is transferred from the malaxator to a storage vessel using a transvasation pump. Inside the storage vessel, this first lot of paste will be homogenized with a second lot of paste (prepared following the same steps described above), for 20 - 30 minutes, at a temperature of 35 - 37°C.
- the paste obtained by homogenizing the two lots is then passed to the feeding container of the tablet molding device.
- the device can be set to mold 5 tablets into one aluminum or opaque PVC blister package.
- the resulting blister packs go through a cooling tunnel, where they stay for 8— 10 minutes at a temperature of 2 - 8°C. After the cooling, the blister packs are moved to the " packaging machine.
- the nutritional supplement according to the invention has the following advantages: it is easy to administer as it is comprised of chewable tablets obtained by incorporating vitamins and minerals into a fatty base, along with other excipients such as powdered milk and powdered sugar;
- the product has an innovative presentation and a very pleasant taste, similar to a dessert, the consumer being protected from the unpleasant taste and smell of certain vitamins and minerals;
- incorporation within a fatty base allows for an easy absorption of vitamins and minerals by the human body;
- the product is recommended for supplementing an unbalanced diet, loss of appetite, periods of intense physical or intellectual effort (the composition that also contains lecithin), convalescence, excessive tiredness, maintaining a healthy retina (the composition that also contains lutein), strengthening the immune system (the composition that also contains Echinacea) and maintaining a general state of good health.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention relates to a nutritional supplement composition presented as chewable tablets and to the method by which it is obtained. The nutritional supplement, according to the invention, contains a mixture of vitamins A, C, B1, B2, B6, D2, H, PP, calcium in the form of gluconate and pantotenat, folic acid, lutein, Echinacea, soy lecithin mixed with a fatty base such as hydrogenated vegetable oil and excipients such as powdered milk, powdered sugar, flavoring agents. The method, according to the invention, consists of successively incorporating the powdered components into a portion of melted fatty base during continuous homogenization, followed by the passage of the mixture through a rolling device, producing an homogenous paste which is then mixed with the remaining melted fatty base and homogenized for 25... 30 minutes at a temperature of 35... 37 °C; the mixture is then placed in a tablet molding device.
Description
COMBINATION OF VITAMINS AND MINERALS
The present invention relates to a nutritional supplement composition which contains a mixture of vitamins and minerals incorporated in a fatty base, accompanied by various flavoring agents and presented as chewable tablets for oral intake, and the method of producing the nutritional supplement composition.
The invention has applicability in the pharmaceutical field.
There are known medicinal compositions containing vitamins A, Bj, B2, calcium pantotenat (RO 77096), vitamin mixtures as molded tablets containing vitamins C, Bl5 B2, D2 (RO 91976) and medicinal compositions in the form of capsules containing vitamins A, C, Bj, B2, B6, B12, D3, E, Ki (RO 118178 B).
The invention solves the problem of preparing a nutritional supplement containing a vitamin and mineral complex as chewable tablets, easy to dose and with pleasant tasting, unlike other currently used products that present themselves as hard tablets, coated tablets or capsules. The composition is also well tolerated by children and adolescents, being presented in an attractive form With various flavors such as (but not limited to) chocolate, vanilla or apricot.
The formula for one chewable tablet contains: Vitamin A (retinol acetate 1500000 IU/g): between 6 μg and 1275 g; Vitamin C (ascorbic acid): between 0.4 mg and 210 mg; Vitamin E (alpha-tocophery acetate): between 0.07 μg and 15 μg; Vitamin Bi (thiamin chlorhydrate): between 0.01 1 mg and 4.8 mg; Vitamin B2 (riboflavin): between 0.01 and 4.8 mg; Vitamin B6 (pyridoxine chlorhydrate): between 0.012 mg and 6 mg; Vitamin D2 (40000 IU/mg) (ergocalciferol): between 0.05 μg and 22.5 μg; Vitamin PP (nicotinic acid): between 0.16 mg and 54 mg; Calcium gluconate: between 13 mg and 3900 mg; Calcium pantotenat: 10 mg; Excipients (up to 5600 mg): fatty base (hydrogenated vegetable fat, such as 100% refined
and hydrogenated palm kernel oil), vanillin, powdered milk, powdered sugar, chocolate/ vanilla/ apricot flavor, natural beta carotene extract, etc.
The following components may be alternatively added to the aforementioned basic composition: Lutein between 0.1 mg and 2 mg; Echinacea between 0.5 g and 3 g, Soy lecithin 250 mg, Vitamin H (Biotin) between 0.25 μg and 105 μg or Folic acid between 4 μg and 1500
This formula of nutritional supplement targets children and adolescents, adults, the elderly (above 65 years of age), pregnant and nursing women. Vitamin and mineral dosage can be adapted to specifically match the needs of every target category.
Here follows an example of the producing method of the invention.
The first step is to melt the fatty base: the necessary quantity of fatty base is minced and melted in the duplicator at 35 - 37°C.
The second step consists of preparing the vitamin powder mixture. The necessary quantities of liposoluble vitamins (vitamins A, D2, and E) are successively homogenized in a portion of molten fatty base. Calcium gluconate powder, powdered sugar and powdered milk are placed in a blending machine called "malaxator" along with vitamins B2, B6, C, nicotinic acid, calcium pantotenat, vanillin and chocolate/ vanilla/apricot flavors etc. and are homogenized for 10 - 15 minutes. The liposoluble vitamins and fatty base mixture is then added to the powder mixture and is homogenized for 10 - 15 minutes.
During the third step the mixture is put through a roller mixer having 3 rolls, setting the distance between the rolls so as to obtain homogenous paste layers.
As a final step, the paste obtained with the roller mixer is returned to the malaxator. The remaining melted fatty based is added to the mix in successive portions and homogenized for approximately 15 - 20 minutes.
Then the paste is transferred from the malaxator to a storage vessel using a transvasation pump. Inside the storage vessel, this first lot of paste will be homogenized with a second lot of paste (prepared following the same steps described above), for 20 - 30 minutes, at a temperature of 35 - 37°C.
The paste obtained by homogenizing the two lots is then passed to the feeding container of the tablet molding device. The device can be set to mold 5 tablets into one aluminum or opaque PVC blister package.
The resulting blister packs go through a cooling tunnel, where they stay for 8— 10 minutes at a temperature of 2 - 8°C. After the cooling, the blister packs are moved to the "packaging machine.
The nutritional supplement according to the invention has the following advantages: it is easy to administer as it is comprised of chewable tablets obtained by incorporating vitamins and minerals into a fatty base, along with other excipients such as powdered milk and powdered sugar;
- the product has an innovative presentation and a very pleasant taste, similar to a dessert, the consumer being protected from the unpleasant taste and smell of certain vitamins and minerals;
- incorporation within a fatty base (hydrogenated vegetable oils) maintains all chemical properties of vitamins and minerals; ,
incorporation within a fatty base (hydrogenated vegetable oils) allows for an easy absorption of vitamins and minerals by the human body;
- the product is recommended for supplementing an unbalanced diet, loss of appetite, periods of intense physical or intellectual effort (the composition that also contains lecithin), convalescence, excessive tiredness, maintaining a healthy retina (the composition that also contains lutein), strengthening the immune system (the
composition that also contains Echinacea) and maintaining a general state of good health.
Claims
1. Nutritional supplement composition containing a mixture of vitamins and minerals, comprising the following formula: 6 μg ... 1275 μg Vitamin A (retinol acetate 1500000 IU/g); 0.4 mg ... 210 mg Vitamin C (ascorbic acid); 0.07 μg ... 15 μg Vitamin E (alpha-tocopheryl acetate); 0.011 mg ... 4.8 mg Vitamin B1 (thiamin chlorhydrate); 0.01 ... 4.8 mg Vitamin B2 (riboflavin); 0.012 mg ... 6 mg Vitamin B6 (pyridoxine chlorhydrate); 0.05 μg ... 22.5 μg Vitamin D2 (40000 IU/mg) (ergocalciferol); 0.16 mg ... 54 mg Vitamin PP (nicotinic acid); 13 mg ... 3900 mg Calcium gluconate; 10 mg Calcium pantotenat; up to 5600 mg excipients : fatty base (hydrogenated vegetable fat, such as 100% refined and hydrogenated palm kernel oil), vanillin, powdered milk, powdered sugar, chocolate/ vanilla/ apricot flavor, natural beta carotene extract, etc., conditioned as chewable tablets and intended for oral administration.
2. Nutritional supplement composition according to Claim 1, wherein 0.1 mg ... 2 mg Lutein are added before the completion with excipients.
3. Nutritional supplement composition according to Claim 1, wherein 0.5 ... 3g Echinacea are added before the completion with excipients.
4. Nutritional supplement composition according to Claim 1, wherein 250 mg Lecithin are added before the completion with excipients.
5. Nutritional supplement composition according to Claim 1, wherein 0.25 μg ...105 μg Vitamin H (Biotin) are added before before the completion with excipients.
6. Nutritional supplement composition according to Claim 1, wherein 4 μg ...1500 |ig Folic acid are added before the completion with excipients.
7. A method of production of the nutritional supplements defined by Claims 1 - 6, comprising the following steps: first mincing the necessary quantity of fatty base, which is then melted in the duplicator at a temperature of 35 - 37 °C; the vitamin powder mixture is prepared next, successively homogenizing the necessary quantities of liposoluble vitamins (vitamins A, D2 and E) in a portion of fatty base; then the powdered calcium gluconate, powdered sugar and powdered milk are homogenized in the malaxator for 10 - 15 minutes along with vitamin Bi, vitamin B2, vitamin B6, nicotinic acid, vitamin C, calcium pantotenat, vanillin, chocolate/ vanilla/ apricot flavors etc.; the mixture of liposoluble vitamins and fatty base is then added to the powder mixture and the resulting mixture is passed through a roller mixer having 3 rolls, setting the distance between rolls so as to produce homogenous paste layers, after which the resulting paste is returned to the malaxator and the remaining melted fatty base is added in successive portions; this mixture is homogenized for 15 - 20 minutes; the resulting paste is then transferred from the malaxator to a storing vessel using a transvasation pump, where it will be mixed and homogenized for 25 - 30 minutes at a temperature of 35 - 37 °C with a second lot of paste obtained through the aforementioned procedure; the resulting paste is transferred to the feeding vessel of the tablet molding device and the resulting blister packs are put through the cooling tunnel for 8 - 10 minutes at a temperature of 2 - 8 °C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ROA201000299 | 2010-04-01 | ||
ROA201000299A RO125888B1 (en) | 2010-04-01 | 2010-04-01 | Process for preparing a food supplement with vitamins and minerals in a fat base |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012023873A1 true WO2012023873A1 (en) | 2012-02-23 |
Family
ID=45349267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RO2011/000012 WO2012023873A1 (en) | 2010-04-01 | 2011-03-31 | Combination of vitamins and minerals |
Country Status (2)
Country | Link |
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RO (1) | RO125888B1 (en) |
WO (1) | WO2012023873A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3323296A1 (en) * | 2016-11-16 | 2018-05-23 | Maresol GmbH & Co. KG | Chocolate with added nutrients and method for producing a chocolate |
WO2019060510A1 (en) * | 2017-09-22 | 2019-03-28 | Nutrivida, Llc | Oral supplement |
WO2020052742A1 (en) * | 2018-09-11 | 2020-03-19 | Parapharm Development Limited | Capsule, tablet or pill |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO91976A2 (en) * | 1985-07-12 | 1987-06-30 | Intreprinderea De Medicamente"Biofarm",Ro | VITAMIN MEDICAL COMPOSITION IN THE FORM OF TURNED TABLETS |
US6340471B1 (en) * | 1999-12-30 | 2002-01-22 | Alvin Kershman | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
US20030138484A1 (en) * | 2001-10-23 | 2003-07-24 | Boehringer Ingelheim International Gmbh | Chewable tablet containing lysine |
US20030206948A1 (en) * | 1997-07-10 | 2003-11-06 | Gerhard Gergely | Soluble, gum-containing, coated chewable tablet |
US20060246116A1 (en) * | 2003-07-18 | 2006-11-02 | Petworks, Llc | Formula and method for the delivery of medications to animals |
-
2010
- 2010-04-01 RO ROA201000299A patent/RO125888B1/en unknown
-
2011
- 2011-03-31 WO PCT/RO2011/000012 patent/WO2012023873A1/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO91976A2 (en) * | 1985-07-12 | 1987-06-30 | Intreprinderea De Medicamente"Biofarm",Ro | VITAMIN MEDICAL COMPOSITION IN THE FORM OF TURNED TABLETS |
US20030206948A1 (en) * | 1997-07-10 | 2003-11-06 | Gerhard Gergely | Soluble, gum-containing, coated chewable tablet |
US6340471B1 (en) * | 1999-12-30 | 2002-01-22 | Alvin Kershman | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
US20030138484A1 (en) * | 2001-10-23 | 2003-07-24 | Boehringer Ingelheim International Gmbh | Chewable tablet containing lysine |
US20060246116A1 (en) * | 2003-07-18 | 2006-11-02 | Petworks, Llc | Formula and method for the delivery of medications to animals |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3323296A1 (en) * | 2016-11-16 | 2018-05-23 | Maresol GmbH & Co. KG | Chocolate with added nutrients and method for producing a chocolate |
WO2019060510A1 (en) * | 2017-09-22 | 2019-03-28 | Nutrivida, Llc | Oral supplement |
WO2020052742A1 (en) * | 2018-09-11 | 2020-03-19 | Parapharm Development Limited | Capsule, tablet or pill |
Also Published As
Publication number | Publication date |
---|---|
RO125888A0 (en) | 2010-12-30 |
RO125888B1 (en) | 2015-07-30 |
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