WO2012022858A1 - Method for preparing and packaging a cosmetic pharmaceutical hydrogel to be applied to the skin - Google Patents
Method for preparing and packaging a cosmetic pharmaceutical hydrogel to be applied to the skin Download PDFInfo
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- WO2012022858A1 WO2012022858A1 PCT/FR2011/000456 FR2011000456W WO2012022858A1 WO 2012022858 A1 WO2012022858 A1 WO 2012022858A1 FR 2011000456 W FR2011000456 W FR 2011000456W WO 2012022858 A1 WO2012022858 A1 WO 2012022858A1
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- hydrogel
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- cosmetic
- skin
- active ingredient
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
- A45D44/002—Masks for cosmetic treatment of the face
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1027—Tissues, i.e. thin applicator sheets
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1036—Applicators comprising a pad, tissue, sponge, or the like containing a cosmetic substance, e.g. impregnated with liquid or containing a soluble solid substance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Definitions
- the present invention relates to the preparation of cosmetic and pharmaceutical compositions in the form of a hydrogel, intended to be applied to the skin.
- This invention particularly relates to a process for preparing and conditioning a thin hydrogel based on a natural thickener and gelling complex comprising carrageenan, glucommanane and galactomannan.
- hydrogels have developed more particularly in the field of facials, in the form of hydrogel masks or patches, which are an alternative to the use of creams or serums.
- hydrogels has several advantages including, in particular, the fact of being able to treat at the same time, homogeneously, relatively large skin areas. It is therefore particularly suitable for care to be carried out on an ad hoc basis, especially over a short period of time.
- hydrogels form a very aqueous medium, relatively little concentrated in salts with respect to the skin, the diffusion of the active ingredients in contact with the skin occurs quite easily by osmosis phenomenon.
- hydrogels therefore has the advantage of treating the skin while moisturizing, which is particularly advantageous in cosmetic facial care, including anti-aging care.
- hydrogels also has interesting prospects in the medical field, particularly in the context of interventions with people whose skin has been burned, skinned or grafted, in particular in the context of a medicine. emergency.
- hydrogels have certain disadvantages that limit their use.
- a first disadvantage of conventional hydrogels lies in their fragility.
- a hydrogel In terms of its chemical structure, a hydrogel is generally obtained by introducing gelling agents into the composition of active ingredients that it is desired to formulate. These gelling agents must be dermatologically neutral and not very concentrated in order to allow free circulation of the active ingredients of the hydrogel to the skin. In addition, the gelling complex must be compatible with the active ingredients that it is desired to formulate with the hydrogel. Hydrogels produced according to this principle are for example described in the international application WO 2008/072817, where agar, cellulose or alginates are used as gelling agents. Such hydrogels are difficult to handle and it is then necessary to use additives other than gelling agents, such as, for example, silk fiber proteins, to reinforce the hydrogel in its structure. In practice, hydrogels of this type have a thickness greater than 2 mm, which makes them too rigid to ensure optimal adhesion to the skin.
- hydrogels formed of several layers.
- International application WO 2001/78678 describes, for example, a device for forming a patch consisting of a hydrophilic rigid layer covered with a thin layer of hydrogel comprising active principles. Such a patch thus has two faces, only one of which, the one covered with hydrogel, is intended to be placed in contact with the skin.
- the application US 2010/0055161 describes another type of device in which a hydrogel comprising active ingredients is formed on a peelable rigid support, which is removed at the time of applying the hydrogel.
- a hydrogel comprising active ingredients is formed on a peelable rigid support, which is removed at the time of applying the hydrogel.
- Such a device is formed of at least three layers, a first consisting of the hydrogel containing the active ingredients, a second consisting of an adhesive intermediate layer not comprising active ingredients, and the third semi-rigid, peelable formed for example a cardboard sheet.
- This type of device has the same disadvantage as the previous one because the hydrogel has a place and a back with a single face to be applied to the skin. Such a device makes the production and use of the hydrogel more complex.
- hydrogels are a particularly favorable medium for the development of microorganisms.
- they can deteriorate rapidly due to a change in their water content, and are subject to desiccation. It can then result, a demixing of the constituents of the hydrogel and leakage of the active ingredients.
- Microbiologically it is essential to be able to produce hydrogels under strict hygienic conditions, that is to say in a clean room with the minimum of human intervention.
- hydrogels Due to regulatory requirements in terms of hygiene and technical constraints related to the manufacture of hydrogels, the masks and patches described in the prior art could not be effectively marketed. Indeed, these hydrogels are generally layered on a unrolled support, then cut with a punch in the thickness of the layer to take the final form in which they will be packaged. This mode of production is not favorable to a strict hygiene of the products intended for the cosmetic or pharmaceutical care.
- the Applicant has developed a stable hydrogel composition based on a gelling and thickening complex comprising carrageenan, glucommanane and galactomannan.
- This particular hydrogel composition has enabled it to obtain a thin, dermatologically neutral hydrogel with a structure sufficiently strong to be easily applied to the skin with optimal adhesion.
- the applicant has managed to produce this hydrogel under conditions of strict hygiene.
- the method consists in directly casting the hydrogel composition in its thermoformed packaging container, inducing the formation of the hydrogel by negative heat shock, and pouring a concentrated composition of the active ingredients onto the hydrogel, once this formed, before permanently sealing the package containing it.
- the active ingredient composition is introduced into the hydrogel in concentrated liquid form, which makes it possible, in particular, to produce hydrogels comprising different active ingredients, starting from the same initial hydrogel composition.
- Hydrogels produced and packaged in this way can be stored for more than 24 months at room temperature in the presence of a preservative system.
- FIG. 1 schematically illustrates steps A to E of the process used to produce and condition the hydrogel, of small thickness, according to the invention, with its active ingredient composition.
- FIG. 2 illustrates the implementation of the method according to the invention.
- Figure 3 illustrates the use that can be made of a hydrogel mask according to the present invention.
- the present invention therefore relates to a particular hydrogel comprising a gelling and thickening complex based on carrageenan, glucomannan and galactomannan.
- this gelling complex makes it possible to obtain a thin hydrogel having favorable mechanical properties, in particular a good resistance to tearing, while not being too rigid. Moreover, the hydrogel thus formed has good absorption and diffusion properties of the active ingredients, as is illustrated below.
- the inventors have been able to determine that the gelling and thickening complex of the hydrogel composition according to the invention optimally comprises between 0.2 and 2% carrageenan by hydrated weight of the hydrogel composition, between 0.2 and 2% glucommanane by hydrated weight of said composition, and between 0.2 and 2% of galactomannan by hydrated weight of said composition.
- galactomannan in the form of locust bean gum (natural extract of seeds of Ceratonia siliqua) has proved particularly favorable for obtaining hydrogels having the desired properties.
- patches or hydrogel masks The thickening and gelling system implemented by the applicant therefore forms a very satisfactory compromise for the manufacture of patches or masks intended to be applied to the skin, hereinafter referred to as patches or hydrogel masks.
- the hydrogel composition according to the invention generally comprises between 0.1 and 0.5% of potassium citrate.
- Potassium citrate advantageously participates in the implementation of the gelling complex and accelerates the formation of the hydrogel.
- the hydrogel composition according to the invention generally further comprises between 1 and 5%, preferably between 1 and 3%, more preferably between 2 and 3% glycerol by hydrated weight of said composition.
- Glycerol or glycerin, hydrophilic molecule is useful for its moisturizing effect, well known to those skilled in the art, which is added to that of the hydrogel itself.
- a preferred hydrogel composition according to the invention thus comprises the following components (% hydrated weight of the composition):
- Locust bean gum 0.2 to 1, 6%
- Carrageenan 0.2 to 1%
- Glucomannan 0.2 to 1%
- hydrogel a gelled composition generally comprising between 85% and 97%, preferably between 90 and 97%, and more preferably between 90 and 95% by weight water hydrated of said composition.
- the hydrogel is obtained from the composition comprising the thickening and gelling system (hydrogel composition) by a negative thermal shock, that is to say by a sudden cooling of the composition making it pass from the liquid or semi-liquid state to the solid state hydrogel.
- the negative thermal shock corresponds to a temperature drop of the composition of at least 20 ° C. to 0 ° C. in less than 20 seconds, preferably in less than 10 seconds and more preferably in less than 8 seconds.
- This cooling is generally obtained by ventilation of air at a negative temperature.
- the negative temperature amplitude is greater than 20 ° C, preferably greater than 30 ° C, and more preferably greater than 40 ° C.
- the subject of the invention is also the process for producing and conditioning industrially the hydrogels according to the invention.
- the hydrogel is preferably formed in the absence of active principles, and that these are added, once the gelled hydrogel, in the form of a liquid composition comprising said active ingredients.
- a cosmetic active ingredient composition may comprise, for example, one of the following active ingredients: papain, aloe vera, extracts of Glycyrrhiza or Scutellaria baicalensis. It can also include as an active ingredient an essential oil.
- this liquid composition is a concentrate of active ingredients, that is to say that the active ingredients are found there at least 5 times more concentrated than in the hydrogel obtained, once the active ingredients have diffused to inside said hydrogel.
- the active ingredients are at least 10 times more concentrated, and even more preferably 20 times more concentrated in active ingredients than the hydrogel obtained at the end of step iv) of the process.
- the composition comprising at least one cosmetic or pharmaceutical active ingredient, brought into contact with the hydrogel in step iv) of the process generally represents less than 20%, preferably less than 10% and more preferably less than 5% the volume of the hydrogel composition initially used to form the hydrogel.
- the composition comprising the active ingredients is rapidly absorbed and diffused homogeneously in the hydrogel.
- the volume of the composition comprising concentrated active ingredients is adjusted so that said composition impregnates the hydrogel in its entirety.
- the volume is adjusted so that the hydrogel reaches a state of saturation, so that a The residual volume of said composition remains in the liquid state in the molded container serving as a hydrogel package.
- This residual volume prevents the hydrogel from drying inside the sealed container.
- the fact of adding the active ingredients in the hydrogel after its formation, in the form of a concentrated liquid composition is advantageous because it allows, with a single production line, to be able to produce hydrogels, in which different active ingredient compositions are included. It suffices for this to provide several tanks, in parallel, each containing a composition comprising different active ingredients.
- the molded container used to produce and condition the hydrogel according to the invention is preferably thermoformed. It is advantageously tinted so that it protects the hydrogel from the effects of light (yellowing, deterioration of mechanical properties) related, especially to UV rays.
- the method according to the invention has, moreover, the advantage of being able to be performed in a clean room in an automated or semi-automated manner. It solves the problem of the industrialization of the hydrogels of the prior art, the mechanical properties of which did not make it possible to carry out such conditioning.
- hydrogels comprising different types of pharmaceutical or cosmetic active ingredients.
- These hydrogels have successfully undergone anti-microbial preservation tests (Challenge test and NFT 75-611 eye safety test) showing that they meet European regulatory requirements for cosmetic products.
- the hydrogel obtained according to this process is generally of average thickness between 0.2 and 1.2 mm, preferably less than 1 mm, more preferably between 0.4 and 0.8 mm.
- the hydrogel according to the invention is preferably contained in a molded container hermetically sealed and loaded with a composition comprising at least one cosmetic or pharmaceutical active ingredient.
- the hydrogel according to the invention preferably takes the form of a mask or a patch that is useful for carrying out medical or cosmetic care on the skin, as illustrated in the examples.
- the present patent application also relates to a pharmaceutical or cosmetic kit consisting of or comprising the hydrogel prepared and packaged according to the method described above.
- This kit is more particularly characterized in that it comprises a molded container, preferably hermetically sealed, containing a hydrogel according to the invention, and a liquid composition comprising active pharmaceutical or cosmetic ingredients. Said active ingredients are preferably present in this liquid composition in concentrated form, as previously defined.
- a hydrogel mask with anti-aging effects may include a liquid composition comprising the following active ingredients (percentages expressed by weight of the hydrated hydrogel):
- a hydrogel mask for the treatment of acne can include an active ingredient composition comprising green tea extracts.
- the invention also aims at a cosmetic process, more particularly a skincare, characterized in that a hydrogel obtained according to the invention is applied to the skin, preferably the face.
- the invention also aims at a method of treating the skin, characterized in that it implements a hydrogel as previously described.
- the examples which follow are intended to complete the description without limiting it.
- Step 1 Preparation of the hydrogel composition
- the ingredients forming the hydrogel composition are mixed in a clean tank in the proportions indicated in Table 1 below, taking care to use purified water.
- Purified water 91% Water represents 91% of the final hydrated weight of the composition.
- the mixture is heated to 80 to 85 ° C, and the composition is allowed to cool to about 40 ° C.
- Step 2 pouring the hydrogel composition
- thermoformed containers preferably made of medical grade PVC tinted anti-UV.
- These thermoformed containers form the base of the package in which the hydrogel mask is then packaged. They have a depth of less than cm for a rectangular surface of about 20 cm x 15 cm.
- the bottom of the container is horizontal and adopts the shape of a flat face. It has positive relief spaces in the mouth, nose and eyes.
- thermoformed container The filling of the bottom of this thermoformed container is carried out using a pump and a metering device, directly into the thermoformed packaging container.
- a volume of about 60 ml of the hydrogel composition is poured into the bottom of the thermoformed container to form a homogeneous layer with a thickness of about 0.5 mm. The latter is distributed evenly around the reliefs of the container reproducing the shape of the eyes, nose and mouth.
- the container loaded with the hydrogel composition is then translated horizontally on the conveyor belt and passes through a cooling tunnel, in which cold air is drawn at a negative temperature ("-4 ° C).
- the passage in the refrigerant tunnel takes about 10 seconds.
- the composition which has suddenly cooled gels and forms a hydrogel which follows the wall of the molded container, having the shape of a mask.
- Step 4 Filling the hydrogel mask with a composition of concentrated cosmetic active ingredients
- a liquid cosmetic composition is obtained by mixing the ingredients in the proportions indicated in Table 2 below, in a second clean tank.
- composition of cosmetic active ingredients is provided.
- This composition aims to moisturize the skin and reduce wrinkles and fine lines as part of an anti-aging care.
- This composition is prepared at ambient temperature ( ⁇ 45 ° C.). Using a pump and a dispenser, a volume of 5 ml of this concentrated active ingredient composition is deposited on the hydrogel in the packaging container. Very quickly, the cosmetic composition is found completely absorbed by the hydrogel.
- Step 5 Heat sealing the container
- thermoformed container containing the hydrogel mask is sealed by heat sealing.
- the lid is thermo-welded at the upper edge of the PVC packaging container around the entire circumference of the mask, and at the top of the reliefs forming the eyes, nose and mouth.
- the container thus being sealed and the hydrogel mask being impregnated with the active ingredient composition, it can be preserved, especially in the presence of a suitable preservative system (eg propytparaben, methylparaben and methylisothiazolinone), without drying out nor corrupt, for more than 24 months. 21 Using the hydrogel mask
- the hydrogel mask produced and packaged in Example 1 above was removed from its individual package by removing the seal. After cleaning the skin, it is positioned on the face of the person wishing to make an anti-aging treatment.
- the person applies the mask so that it perfectly matches the shape of his face.
- the mask is left in place for about 20 minutes, allowing the active ingredients in the hydrogel to penetrate the skin (upper layers of the stratum corneum).
- the person When the mask is removed, the person removes the excess liquid on the surface of his skin using a tissue paper.
- This technique consists of calculating a phase image from interference fringe projection images. This image makes it possible to go back to the altitude of each point.
- the acquisition software then makes it possible to obtain 2D measurements and
- 3D determines the parameters of the cutaneous relief on 32 profiles distributed in star on the zone of interest.
- An automatic repositioning system allows precise re-identification of the measurement area.
- Average roughness is defined as the ratio of the integrated area around the average value over the length of the profile. A decrease in Ra reflects a smoothing effect.
- the median relief value is the average of the five maxima of the median relief (vertical distance from the third highest peak and the third deepest hollow).
- a decrease in R3z reflects a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
- the average relief is the average value of all maxima (between peak and trough) over the length of the profile.
- a decrease in Rz reflects a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
- Rt the amplitude (in pm): it is about the average value of the five largest maxima (between peak and hollow) on the length of the profile.
- a decrease of Rt translates a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
- a subjective evaluation questionnaire prepared by the clinical trial center, was completed by 22 volunteers at the end of the study in order to subjectively evaluate the characteristics of the studied product, as well as its overall effectiveness.
- Crystaie de Collagena "induced a smoothing and tensing effect immediately after a single standardized application.
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Abstract
The present invention relates to a method for preparing, producing, and packaging a hydrogel to be applied to the skin in a thin layer, containing a gelling and thickening complex including carrageenan, glucomannan and galactomannan. Specifically, said hydrogel is provided in the form of a mask or patches in a kit for the cosmetic care of the face. The hydrogel of the invention is obtained and packaged according to a method including a first step of forming the hydrogel by the application of a negative heat shock inside the packaging thereof, then a second step of adding the cosmetic or pharmaceutical active principles in the form of a concentrated liquid composition, and a third step in which the packaging is hermetically sealed.
Description
Procédé de préparation et de conditionnement d'un hydrogel cosmétique du pharmaceutique destiné à être appliqué sur la peau Process for preparing and conditioning a cosmetic pharmaceutical hydrogel intended to be applied to the skin
La présente invention concerne la préparation de compositions cosmétiques et pharmaceutiques sous forme d'hydrogel, destinées à être appliquées sur la peau. The present invention relates to the preparation of cosmetic and pharmaceutical compositions in the form of a hydrogel, intended to be applied to the skin.
Cette invention a notamment pour objet un procédé de préparation et de conditionnement d'un hydrogel de faible épaisseur à base d'un complexe épaississant et gélifiant naturel comprenant du carraghénane, du glucommanane et du galactomannane. This invention particularly relates to a process for preparing and conditioning a thin hydrogel based on a natural thickener and gelling complex comprising carrageenan, glucommanane and galactomannan.
Depuis plusieurs années se sont développés des soins de la peau où les agents cosmétiques ou pharmaceutiques sont formulés sous forme d'hydrogel, c'est-à-dire sous forme de compositions aqueuses gélifiées. For several years have developed skin care where the cosmetic or pharmaceutical agents are formulated as a hydrogel, that is to say in the form of gelled aqueous compositions.
Ces hydrogels se sont développés plus particulièrement dans le domaine des soins du visage, sous la forme de masques hydrogels ou de patchs, qui constituent une alternative à l'emploi de crèmes ou de sérums. These hydrogels have developed more particularly in the field of facials, in the form of hydrogel masks or patches, which are an alternative to the use of creams or serums.
L'utilisation d'hydrogels cumule plusieurs avantages dont, notamment, le fait de pouvoir traiter au même moment, de manière homogène, des surfaces de peau relativement importantes. Il est donc particulièrement adapté aux soins devant s'effectuer de manière ponctuelle, notamment sur une courte durée. The use of hydrogels has several advantages including, in particular, the fact of being able to treat at the same time, homogeneously, relatively large skin areas. It is therefore particularly suitable for care to be carried out on an ad hoc basis, especially over a short period of time.
Par ailleurs, du fait que les hydrogels forment un milieu très aqueux, relativement peu concentré en sels par rapport à la peau, la diffusion des principes actifs au contact de la peau s'opère assez facilement par phénomène d'osmose. Moreover, because the hydrogels form a very aqueous medium, relatively little concentrated in salts with respect to the skin, the diffusion of the active ingredients in contact with the skin occurs quite easily by osmosis phenomenon.
L'utilisation d'hydrogels présente donc l'avantage de traiter la peau tout en l'hydratant, ce qui est particulièrement avantageux dans les soins cosmétiques du visage, notamment les soins anti-âge. The use of hydrogels therefore has the advantage of treating the skin while moisturizing, which is particularly advantageous in cosmetic facial care, including anti-aging care.
Ce faisant, l'utilisation d'hydrogels connaît également des perspectives intéressantes dans le domaine médical, notamment dans le cadre d'interventions auprès de personnes dont la peau a été brûlée, écorchée ou greffée, notamment dans le cadre d'une médecine d'urgence. In doing so, the use of hydrogels also has interesting prospects in the medical field, particularly in the context of interventions with people whose skin has been burned, skinned or grafted, in particular in the context of a medicine. emergency.
Cependant, les hydrogels actuellement disponibles présentent certains inconvénients qui limitent leur utilisation.
Un premier inconvénient des hydrogels conventionnels réside dans leur fragilité. However, currently available hydrogels have certain disadvantages that limit their use. A first disadvantage of conventional hydrogels lies in their fragility.
Sur le plan de sa structure chimique, un hydrogel est obtenu généralement en introduisant des gélifiants dans la composition de principes actifs que l'on souhaite formuler. Ces gélifiants doivent être neutres sur le plan dermatologique et peu concentrés pour pouvoir laisser librement circuler les principes actifs de l'hydrogel vers la peau. De plus, le complexe gélifiant doit être compatible avec les principes actifs que l'on souhaite formuler avec l'hydrogel. Des hydrogels produits selon ce principe sont par exemple décrits dans la demande internationale WO 2008/072817, où l'on utilise comme gélifiants de l'agar, de la cellulose ou des alginates. De tels hydrogels sont difficiles à manipuler et il est alors nécessaire d'utiliser des additifs autres que des gélifiants, telles que par exemple, des protéines de fibres de soie, pour renforcer l'hydrogel dans sa structure. En pratique, les hydrogels de ce type présentent une épaisseur supérieure à 2 mm, ce qui les rend trop rigides pour pouvoir assurer une adhérence à la peau qui soit optimale. In terms of its chemical structure, a hydrogel is generally obtained by introducing gelling agents into the composition of active ingredients that it is desired to formulate. These gelling agents must be dermatologically neutral and not very concentrated in order to allow free circulation of the active ingredients of the hydrogel to the skin. In addition, the gelling complex must be compatible with the active ingredients that it is desired to formulate with the hydrogel. Hydrogels produced according to this principle are for example described in the international application WO 2008/072817, where agar, cellulose or alginates are used as gelling agents. Such hydrogels are difficult to handle and it is then necessary to use additives other than gelling agents, such as, for example, silk fiber proteins, to reinforce the hydrogel in its structure. In practice, hydrogels of this type have a thickness greater than 2 mm, which makes them too rigid to ensure optimal adhesion to the skin.
Pour pallier la fragilité des hydrogels conventionnels, il est proposé dans l'art antérieur, des hydrogels formés de plusieurs couches. La demande internationale WO 2001/78678 décrit, par exemple, un dispositif pour former un patch constitué d'une couche rigide hydrophile recouverte d'une fine couche d'hydrogel comprenant des principes actifs. Un tel patch présente donc deux faces, dont l'une seulement, celle recouverte d'hydrogel, est destinée à être placée au contact de la peau. To overcome the fragility of conventional hydrogels, it is proposed in the prior art, hydrogels formed of several layers. International application WO 2001/78678 describes, for example, a device for forming a patch consisting of a hydrophilic rigid layer covered with a thin layer of hydrogel comprising active principles. Such a patch thus has two faces, only one of which, the one covered with hydrogel, is intended to be placed in contact with the skin.
La demande US 2010/0055161 décrit un autre type de dispositif dans lequel un hydrogel comprenant des principes actifs est constitué sur un support rigide pelable, que l'on retire au moment d'appliquer l'hydrogel. Un tel dispositif est formé d'au moins trois couches, une première constituée de l'hydrogel contenant les principes actifs, une seconde constituée d'une couche intermédiaire adhésive ne comprenant pas de principes actifs, et la troisième semi-rigide, pelable, formée par exemple d'une feuille cartonnée. Ce type de dispositif présente le même inconvénient que le précédent car l'hydrogel présente un endroit et un envers avec une seule face devant être
appliquée à la peau. Un tel dispositif rend plus complexe la production et l'utilisation de l'hydrogel. The application US 2010/0055161 describes another type of device in which a hydrogel comprising active ingredients is formed on a peelable rigid support, which is removed at the time of applying the hydrogel. Such a device is formed of at least three layers, a first consisting of the hydrogel containing the active ingredients, a second consisting of an adhesive intermediate layer not comprising active ingredients, and the third semi-rigid, peelable formed for example a cardboard sheet. This type of device has the same disadvantage as the previous one because the hydrogel has a place and a back with a single face to be applied to the skin. Such a device makes the production and use of the hydrogel more complex.
Un autre inconvénient des hydrogels réside dans leur conservation. En raison du fait qu'ils contiennent une proportion importante d'eau, les hydrogels constituent un milieu particulièrement favorable au développement des microorganismes. Ils peuvent, en outre, se détériorer rapidement du fait d'une variation de leur teneur en eau, et sont sujets à la dessiccation. Il peut alors en résulter, une démixtion des constituants de l'hydrogel et une fuite des principes actifs. Another disadvantage of hydrogels is their preservation. Due to the fact that they contain a large proportion of water, hydrogels are a particularly favorable medium for the development of microorganisms. In addition, they can deteriorate rapidly due to a change in their water content, and are subject to desiccation. It can then result, a demixing of the constituents of the hydrogel and leakage of the active ingredients.
Sur le plan microbiologique, il est impératif de pouvoir produire les hydrogels dans des conditions d'hygiène strictes, c'est-à-dire dans une salle blanche avec le minimum d'intervention humaine. Microbiologically, it is essential to be able to produce hydrogels under strict hygienic conditions, that is to say in a clean room with the minimum of human intervention.
Du fait des exigences réglementaires en matière d'hygiène et des contraintes techniques liées à la fabrication des hydrogels, les masques et patch décrits dans l'art antérieur n'ont pas pu faire l'objet d'une commercialisation effective. En effet, ces hydrogels sont généralement produits en couche sur un support déroulé, puis découpés à l'emporte-pièce dans l'épaisseur de la couche pour prendre la forme définitive dans laquelle ils seront conditionnés. Ce mode de production n'est pas favorable à une hygiène stricte des produits destinés aux soins cosmétiques ou pharmaceutiques. Due to regulatory requirements in terms of hygiene and technical constraints related to the manufacture of hydrogels, the masks and patches described in the prior art could not be effectively marketed. Indeed, these hydrogels are generally layered on a unrolled support, then cut with a punch in the thickness of the layer to take the final form in which they will be packaged. This mode of production is not favorable to a strict hygiene of the products intended for the cosmetic or pharmaceutical care.
De manière inattendue, le demandeur a mis au point une composition d'hydrogel stable à base d'un complexe gélifiant et épaississant comprenant de la carraghénane, du glucommanane et du galactomannane. Surprisingly, the Applicant has developed a stable hydrogel composition based on a gelling and thickening complex comprising carrageenan, glucommanane and galactomannan.
Cette composition d'hydrogel particulière lui a permis d'obtenir un hydrogel de faible épaisseur, neutre sur le plan dermatologique, et ayant une structure suffisamment résistante pour être facilement appliqué sur la peau avec une adhérence optimale. This particular hydrogel composition has enabled it to obtain a thin, dermatologically neutral hydrogel with a structure sufficiently strong to be easily applied to the skin with optimal adhesion.
Outre le fait que l'hydrogel est obtenu par un choc thermique négatif, le demandeur est parvenu à produire cet hydrogel dans des conditions d'hygiène stricte.
Le procédé consiste à couler directement la composition d'hydrogel dans son récipient d'emballage thermoformé, à induire la formation de l'hydrogel par choc thermique négatif, et à verser une composition concentrée des principes actifs sur l'hydrogel, une fois celui-ci formé, avant de sceller définitivement l'emballage le contenant. In addition to the fact that the hydrogel is obtained by a negative heat shock, the applicant has managed to produce this hydrogel under conditions of strict hygiene. The method consists in directly casting the hydrogel composition in its thermoformed packaging container, inducing the formation of the hydrogel by negative heat shock, and pouring a concentrated composition of the active ingredients onto the hydrogel, once this formed, before permanently sealing the package containing it.
De manière avantageuse, la composition de principe actif est introduite dans l'hydrogel sous forme liquide concentrée, ce qui permet, notamment, de produire des hydrogels comprenant des principes actifs différents, à partir d'une même composition initiale d'hydrogel. Advantageously, the active ingredient composition is introduced into the hydrogel in concentrated liquid form, which makes it possible, in particular, to produce hydrogels comprising different active ingredients, starting from the same initial hydrogel composition.
Les hydrogels produits et conditionnés de cette façon peuvent être conservés plus de 24 mois à température ambiante en présence d'un système conservateur. Hydrogels produced and packaged in this way can be stored for more than 24 months at room temperature in the presence of a preservative system.
D'autres avantages de la composition d'hydrogel et du procédé selon l'invention sont détaillés ci-après. Other advantages of the hydrogel composition and the process according to the invention are detailed below.
La figure 1 illustre de manière schématique les étapes A à E du procédé mis en œuvre pour produire et conditionner l'hydrogel, de faible épaisseur, selon l'invention, avec sa composition de principe actif. La figure 2 illustre la mise en œuvre du procédé selon l'invention. FIG. 1 schematically illustrates steps A to E of the process used to produce and condition the hydrogel, of small thickness, according to the invention, with its active ingredient composition. FIG. 2 illustrates the implementation of the method according to the invention.
La figure 3 illustre l'utilisation qui peut être faite d'un masque hydrogel selon la présente invention. La présente invention a donc pour objet un hydrogel particulier comprenant un complexe gélifiant et épaississant à base de carraghénane, de glucomannane et de galactomannane. Figure 3 illustrates the use that can be made of a hydrogel mask according to the present invention. The present invention therefore relates to a particular hydrogel comprising a gelling and thickening complex based on carrageenan, glucomannan and galactomannan.
Les inventeurs ont pu déterminer que ce complexe gélifiant permettait d'obtenir un hydrogel de faible épaisseur ayant des propriétés mécaniques favorables, notamment une bonne résistance au déchirement, tout en étant pas trop rigide. Par ailleurs, l'hydrogel ainsi formé présente de
bonnes propriétés d'absorption et de diffusion des principes actifs, ainsi que cela est illustré plus loin. The inventors have been able to determine that this gelling complex makes it possible to obtain a thin hydrogel having favorable mechanical properties, in particular a good resistance to tearing, while not being too rigid. Moreover, the hydrogel thus formed has good absorption and diffusion properties of the active ingredients, as is illustrated below.
Les inventeurs ont pu déterminer que le complexe gélifiant et épaississant de la composition d'hydrogel selon l'invention comprend, de manière optimale, entre 0,2 et 2 % de carraghénane en poids hydraté de la composition d'hydrogel, entre 0,2 et 2 % de glucommanane en poids hydraté de ladite composition, et entre 0,2 et 2 % de galactomannane en poids hydraté de ladite composition. The inventors have been able to determine that the gelling and thickening complex of the hydrogel composition according to the invention optimally comprises between 0.2 and 2% carrageenan by hydrated weight of the hydrogel composition, between 0.2 and 2% glucommanane by hydrated weight of said composition, and between 0.2 and 2% of galactomannan by hydrated weight of said composition.
L'emploi de galactomannane sous forme de gomme de caroube (extrait naturel de graines de Ceratonia siliqua) s'est avéré particulièrement favorable à l'obtention d'hydrogels ayant les propriétés recherchées. The use of galactomannan in the form of locust bean gum (natural extract of seeds of Ceratonia siliqua) has proved particularly favorable for obtaining hydrogels having the desired properties.
Le système épaississant et gélifiant mis en œuvre par le déposant forme donc un compromis très satisfaisant pour la fabrication de patchs ou de masques destiné à être appliqué sur la peau, ci-après désignés patchs ou masques hydrogels. The thickening and gelling system implemented by the applicant therefore forms a very satisfactory compromise for the manufacture of patches or masks intended to be applied to the skin, hereinafter referred to as patches or hydrogel masks.
La composition d'hydrogel selon l'invention comprend généralement entre 0,1 et 0,5 % de citrate de potassium. Le citrate de potassium participe avantageusement à la mise en œuvre du complexe gélifiant et accélère la formation de l'hydrogel. The hydrogel composition according to the invention generally comprises between 0.1 and 0.5% of potassium citrate. Potassium citrate advantageously participates in the implementation of the gelling complex and accelerates the formation of the hydrogel.
La composition d'hydrogel selon l'invention comprend généralement, en outre, entre 1 et 5 %, de préférence entre 1 et 3 %, plus préférentiellement entre 2 et 3 % de glycérol en poids hydraté de ladite composition. Le glycérol ou glycérine, molécule hydrophile, est utile pour son effet hydratant, bien connu de l'homme du métier, qui vient s'ajouter à celui de l'hydrogel lui-même. The hydrogel composition according to the invention generally further comprises between 1 and 5%, preferably between 1 and 3%, more preferably between 2 and 3% glycerol by hydrated weight of said composition. Glycerol or glycerin, hydrophilic molecule, is useful for its moisturizing effect, well known to those skilled in the art, which is added to that of the hydrogel itself.
Une composition d'hydrogel préférée selon l'invention comprend ainsi les composants suivants (% de poids hydraté de la composition) : A preferred hydrogel composition according to the invention thus comprises the following components (% hydrated weight of the composition):
Glycérol : 1 à 5 % Glycerol: 1 to 5%
Gomme de caroube : 0,2 à 1 ,6 % Locust bean gum: 0.2 to 1, 6%
Carraghénane : 0,2 à 1 % Carrageenan: 0.2 to 1%
Glucomannane : 0,2 à 1 % Glucomannan: 0.2 to 1%
Citrate de potassium : 0,1 à 0,5 %
Acide citrique : 0,01 à 0,05 % Potassium citrate: 0.1 to 0.5% Citric acid: 0.01 to 0.05%
Eau purifiée : qsp. Purified water: qsp.
Par hydrogel, on entend une composition gélifiée comprenant généralement entre 85 % et 97 %, préférentiellement entre 90 et 97 %, et plus préférentiellement entre 90 et 95 % d'eau en poids hydraté de ladite composition. By hydrogel is meant a gelled composition generally comprising between 85% and 97%, preferably between 90 and 97%, and more preferably between 90 and 95% by weight water hydrated of said composition.
Selon l'invention, l'hydrogel est obtenu à partir de la composition comprenant le système épaississant et gélifiant (composition d'hydrogel) par un choc thermique négatif, c'est-à-dire par un refroidissement brutal de la composition la faisant passer de l'état liquide ou semi-liquide à l'état solide hydrogel. According to the invention, the hydrogel is obtained from the composition comprising the thickening and gelling system (hydrogel composition) by a negative thermal shock, that is to say by a sudden cooling of the composition making it pass from the liquid or semi-liquid state to the solid state hydrogel.
En général, le choc thermique négatif correspond à une chute de température de la composition d'au moins 20°C à 0°C en moins de 20 secondes, de préférence en moins de 10 secondes et plus préférentiellement en moins de 8 secondes. Ce refroidissement est généralement obtenu par ventilation d'air à une température négative. Avantageusement, l'amplitude négative de température est supérieure à 20°C, préférentiellement supérieure à 30 °C, et plus préférentiellement supérieure à 40°C. In general, the negative thermal shock corresponds to a temperature drop of the composition of at least 20 ° C. to 0 ° C. in less than 20 seconds, preferably in less than 10 seconds and more preferably in less than 8 seconds. This cooling is generally obtained by ventilation of air at a negative temperature. Advantageously, the negative temperature amplitude is greater than 20 ° C, preferably greater than 30 ° C, and more preferably greater than 40 ° C.
L'invention a également pour objet le procédé permettant de produire et de conditionner industriellement les hydrogels selon l'invention. The subject of the invention is also the process for producing and conditioning industrially the hydrogels according to the invention.
Ce procédé se caractérise, notamment, en ce qu'il comprend une ou plusieurs des étapes suivantes : This method is characterized in that it comprises one or more of the following steps:
i) on prépare une composition d'hydrogel comprenant un complexe gélifiant et épaississant, telle que décrite précédemment; i) preparing a hydrogel composition comprising a gelling and thickening complex, as described above;
ii) on coule cette composition d'hydrogel à l'état liquide ou semi- liquide dans un récipient moulé afin de former au fond dudit récipient une couche d'une épaisseur moyenne comprise entre 0,2 et 1,2 mm, de préférence entre 0,4 et 1 mm, plus préférentiellement entre 0,5 et 0,8 mm; iii) on soumet ladite composition dans son récipient moulé, à un choc thermique négatif de sorte à ce que ladite composition d'hydrogel gélifie au contact de la paroi du récipient moulé;
iv) on verse sur l'hydrogel formé à l'étape iii) dans ledit récipient moulé, une composition liquide comprenant au moins un principe actif cosmétique ou pharmaceutique, de préférence sous forme concentrée; ii) pouring said hydrogel composition in a liquid or semi-liquid state into a molded container so as to form at the bottom of said container a layer having an average thickness of between 0.2 and 1.2 mm, preferably between 0.4 and 1 mm, more preferably between 0.5 and 0.8 mm; iii) subjecting said composition in its molded container to a negative thermal shock so that said hydrogel composition gels in contact with the wall of the molded container; iv) pouring on the hydrogel formed in step iii) in said molded container, a liquid composition comprising at least one cosmetic or pharmaceutical active ingredient, preferably in concentrated form;
v) on scelle hermétiquement ledit récipient contenant l'hydrogel et la composition de principe actif, de préférence par thermo-soudure; v) sealing said container containing the hydrogel and the active ingredient composition, preferably by heat-sealing;
On notera que, selon l'invention, l'hydrogel est préférentiellement formé en l'absence de principes actifs, et que ceux-ci sont ajoutés, une fois l'hydrogel gélifié, sous forme d'une composition liquide comprenant lesdits principes actifs. It will be noted that, according to the invention, the hydrogel is preferably formed in the absence of active principles, and that these are added, once the gelled hydrogel, in the form of a liquid composition comprising said active ingredients.
Une composition de principe actif cosmétique peut comprendre, par exempte, un des principes actifs suivants : papaïne, aloe vera, extraits de Glycyrrhiza ou de Scutellaria baicalensis. Elle peut également comprendre comme principe actif une huile essentielle. A cosmetic active ingredient composition may comprise, for example, one of the following active ingredients: papain, aloe vera, extracts of Glycyrrhiza or Scutellaria baicalensis. It can also include as an active ingredient an essential oil.
En général, cette composition liquide est un concentré de principes actifs, c'est-à-dire que les principes actifs s'y trouvent au moins 5 fois plus concentrés que dans l'hydrogel obtenu, une fois que les principes actifs ont diffusé à l'intérieur dudit hydrogel. In general, this liquid composition is a concentrate of active ingredients, that is to say that the active ingredients are found there at least 5 times more concentrated than in the hydrogel obtained, once the active ingredients have diffused to inside said hydrogel.
De préférence, les principes actifs sont au moins 10 fois plus concentrés, et encore plus préférentiellement 20 fois plus concentrés en principes actifs que l'hydrogel obtenu à l'issue de l'étape iv) du procédé. Preferably, the active ingredients are at least 10 times more concentrated, and even more preferably 20 times more concentrated in active ingredients than the hydrogel obtained at the end of step iv) of the process.
Ainsi, la composition comprenant au moins un principe actif cosmétique ou pharmaceutique, mise en contact avec l'hydrogel à l'étape iv) du procédé, représente généralement moins de 20 %, de préférence moins de 10 % et plus préférentiellement moins de 5 % du volume de la composition d'hydrogel utilisée initialement pour former l'hydrogel. Thus, the composition comprising at least one cosmetic or pharmaceutical active ingredient, brought into contact with the hydrogel in step iv) of the process, generally represents less than 20%, preferably less than 10% and more preferably less than 5% the volume of the hydrogel composition initially used to form the hydrogel.
De part les propriétés de l'hydrogel selon l'invention, la composition comprenant les principes actifs est rapidement absorbée et diffusée de manière homogène dans l'hydrogel. Due to the properties of the hydrogel according to the invention, the composition comprising the active ingredients is rapidly absorbed and diffused homogeneously in the hydrogel.
Avantageusement, le volume de la composition comprenant des principes actifs concentrés est ajusté de sorte à ce que ladite composition imprègne l'hydrogel dans sa totalité. De préférence, le volume est ajusté pour que l'hydrogel parvienne à un état de saturation, de telle sorte qu'un
volume résiduel de ladite composition demeure à l'état liquide dans le récipient moulé servant d'emballage à l'hydrogel. Advantageously, the volume of the composition comprising concentrated active ingredients is adjusted so that said composition impregnates the hydrogel in its entirety. Preferably, the volume is adjusted so that the hydrogel reaches a state of saturation, so that a The residual volume of said composition remains in the liquid state in the molded container serving as a hydrogel package.
Ce volume résiduel empêche l'hydrogel de sécher à l'intérieur du récipient scellé. This residual volume prevents the hydrogel from drying inside the sealed container.
Au demeurant, les inventeurs ont constaté que lorsque le volume résiduel liquide était trop important à l'intérieur de l'emballage scellé, un second choc thermique négatif, une fois l'emballage scellé, permettait de résorber ce volume à l'intérieur de l'hydrogel par absorption. Moreover, the inventors have found that when the residual liquid volume was too great inside the sealed package, a second negative heat shock, once the sealed package, allowed to resorb the volume inside the sealed package. hydrogel by absorption.
Sur le plan industriel, le fait d'ajouter les principes actifs dans l'hydrogel postérieurement à sa formation, sous forme d'une composition liquide concentrée, est avantageux car cela permet, avec une seule ligne de production, de pouvoir produire des hydrogels, dans lesquels différentes compositions de principes actifs sont incluses. Il suffit pour cela de prévoir plusieurs cuves, en parallèle, contenant chacune une composition comprenant des principes actifs différents. At the industrial level, the fact of adding the active ingredients in the hydrogel after its formation, in the form of a concentrated liquid composition, is advantageous because it allows, with a single production line, to be able to produce hydrogels, in which different active ingredient compositions are included. It suffices for this to provide several tanks, in parallel, each containing a composition comprising different active ingredients.
Le récipient moulé utilisé pour produire et conditionner l'hydrogel selon l'invention, est de préférence thermoformé. Il est avantageusement teinté de telle sorte qu'il protège l'hydrogel des effets de la lumière (jaunissement, détérioration des propriétés mécaniques) liés, notamment aux rayons UV. The molded container used to produce and condition the hydrogel according to the invention is preferably thermoformed. It is advantageously tinted so that it protects the hydrogel from the effects of light (yellowing, deterioration of mechanical properties) related, especially to UV rays.
Le procédé selon l'invention présente, par ailleurs, l'avantage de pouvoir être réalisé dans une salle blanche de manière automatisée ou semi- automatisée. Il résout le problème de l'industrialisation des hydrogels de l'art antérieur, dont les propriétés mécaniques ne permettaient pas de réaliser un tel conditionnement. The method according to the invention has, moreover, the advantage of being able to be performed in a clean room in an automated or semi-automated manner. It solves the problem of the industrialization of the hydrogels of the prior art, the mechanical properties of which did not make it possible to carry out such conditioning.
En effectuant ces étapes, le demandeur est en effet parvenu à produire de manière répétitive, et à façon, des hydrogels comprenant différents types de principes actifs pharmaceutiques ou cosmétiques. Ces hydrogels ont subi avec succès des tests de conservation anti-microbienne (Challenge test et test d'innocuité oculaire selon la norme NFT 75-611 ) montrant qu'ils satisfont les exigences réglementaires européennes en matière de produits cosmétiques.
L'hydrogel obtenu selon ce procédé est généralement d'une épaisseur moyenne comprise entre 0,2 et 1,2 mm, de préférence inférieure à 1 mm, plus préférentiellement entre 0,4 et 0,8 mm. By performing these steps, the applicant has indeed managed to produce repetitively, and in a manner, hydrogels comprising different types of pharmaceutical or cosmetic active ingredients. These hydrogels have successfully undergone anti-microbial preservation tests (Challenge test and NFT 75-611 eye safety test) showing that they meet European regulatory requirements for cosmetic products. The hydrogel obtained according to this process is generally of average thickness between 0.2 and 1.2 mm, preferably less than 1 mm, more preferably between 0.4 and 0.8 mm.
Dans sa forme conditionnée, l'hydrogel selon l'invention est de préférence contenu dans un récipient moulé scellé hermétiquement et chargé d'une composition comprenant au moins un principe actif cosmétique ou pharmaceutique. In its packaged form, the hydrogel according to the invention is preferably contained in a molded container hermetically sealed and loaded with a composition comprising at least one cosmetic or pharmaceutical active ingredient.
L'hydrogel selon l'invention prend préférentiellement la forme d'un masque ou d'un patch utile pour effectuer des soins médicaux ou cosmétiques sur la peau, comme cela est illustré dans les exemples. The hydrogel according to the invention preferably takes the form of a mask or a patch that is useful for carrying out medical or cosmetic care on the skin, as illustrated in the examples.
La présente demande de brevet vise également un kit pharmaceutique ou cosmétique constitué ou comprenant l'hydrogel préparé et conditionné selon le procédé décrit précédemment. The present patent application also relates to a pharmaceutical or cosmetic kit consisting of or comprising the hydrogel prepared and packaged according to the method described above.
Ce kit se caractérise plus particulièrement en ce qu'il comprend un récipient moulé, de préférence scellé hermétiquement, contenant un hydrogel selon l'invention, ainsi qu'une composition liquide comprenant des principes actifs pharmaceutiques ou cosmétiques. Lesdits principes actifs sont de préférence présents dans cette composition liquide sous forme concentrée, tel que précédemment défini. This kit is more particularly characterized in that it comprises a molded container, preferably hermetically sealed, containing a hydrogel according to the invention, and a liquid composition comprising active pharmaceutical or cosmetic ingredients. Said active ingredients are preferably present in this liquid composition in concentrated form, as previously defined.
A titre d'exemple, un masque hydrogel aux effets anti-âge peut inclure une composition liquide comprenant les principes actifs suivants (pourcentages exprimés en poids de l'hydrogel hydraté) : By way of example, a hydrogel mask with anti-aging effects may include a liquid composition comprising the following active ingredients (percentages expressed by weight of the hydrated hydrogel):
- entre 1 et 5 % d'hydrolysat de collagène ; between 1 and 5% of collagen hydrolyzate;
- entre 0,3 et 5 % de glucane d'avoine ; et 0.3 to 5% of oat glucan; and
- entre 0,2 et 1 % d'acide hyaluronique. between 0.2 and 1% of hyaluronic acid.
Un masque hydrogel pour le traitement de l'acné peut inclure une composition de principes actifs comprenant des extraits de thé vert. A hydrogel mask for the treatment of acne can include an active ingredient composition comprising green tea extracts.
L'invention a également pour finalité un procédé cosmétique, plus particulièrement un soin de la peau, caractérisé en ce qu'on applique sur la peau, de préférence le visage, un hydrogel obtenu selon l'invention.
L'invention a également pour finalité une méthode de traitement de la peau, caractérisée en ce qu'elle met en œuvre un hydrogel tel que précédemment décrit. Les exemples qui suivent, visent à compléter la description sans y apporter de limitation. The invention also aims at a cosmetic process, more particularly a skincare, characterized in that a hydrogel obtained according to the invention is applied to the skin, preferably the face. The invention also aims at a method of treating the skin, characterized in that it implements a hydrogel as previously described. The examples which follow are intended to complete the description without limiting it.
Exemples de réalisation Examples of realization
1/ Préparation d'un masque hvdroael 1 / Preparation of a hvdroael mask
Les différentes étapes 1 à 5 ci-dessous correspondent à celles illustrées A à E dans la figure 1. The various steps 1 to 5 below correspond to those illustrated A to E in FIG.
Etape 1 : Préparation de la composition d'hydrogel Step 1: Preparation of the hydrogel composition
Dans une salle blanche, les ingrédients formant la composition hydrogel sont mélangés dans une cuve propre dans les proportions indiquées dans le tableau 1 ci-dessous, en prenant soin d'utiliser de l'eau purifiée. In a clean room, the ingredients forming the hydrogel composition are mixed in a clean tank in the proportions indicated in Table 1 below, taking care to use purified water.
Tableau 1 Table 1
Composition hydrogel Hydrogel composition
Glycérol 5.0 % Glycerol 5.0%
Galactomannan 1.6 % Galactomannan 1.6%
(gomme de caroube) (carob gum)
Carraghénane 1.0 % Carrageenan 1.0%
Glucomannan 0.8 % Glucomannan 0.8%
Citrate de potassium 0.5 % 0.5% potassium citrate
Acide citrique 0.05 % Citric acid 0.05%
Système conservateur 0.05 % Conservative system 0.05%
Eau purifiée 91 %
L'eau représente 91 % du poids hydraté final de ia composition. Le mélange est porté entre 80 et 85°C, puis on laisse la composition refroidir à environ 40°C. Purified water 91% Water represents 91% of the final hydrated weight of the composition. The mixture is heated to 80 to 85 ° C, and the composition is allowed to cool to about 40 ° C.
Etape 2 : Coulage de la composition d'hydrogel Step 2: Pouring the hydrogel composition
La composition d'hydrogel est coulée à température ambiante dans un récipient thermoformé, préférentiellement réalisé en PVC de qualité médicale teinté anti-UV. Ces récipients thermoformés forment la base de l'emballage dans lequel le masque hydrogel est ensuite conditionné. Ils présentent une profondeur de moins d' cm pour une surface rectangulaire d'environ 20 cm x 15 cm. Le fond du récipient est horizontal et adopte la forme d'un visage à plat. Il présente des espaces en relief positif au niveau de la bouche, du nez et des yeux. The hydrogel composition is cast at room temperature in a thermoformed container, preferably made of medical grade PVC tinted anti-UV. These thermoformed containers form the base of the package in which the hydrogel mask is then packaged. They have a depth of less than cm for a rectangular surface of about 20 cm x 15 cm. The bottom of the container is horizontal and adopts the shape of a flat face. It has positive relief spaces in the mouth, nose and eyes.
Le remplissage du fond de ce récipient thermoformé s'effectue à l'aide d'une pompe et d'un doseur, directement dans le récipient emballage thermoformé. The filling of the bottom of this thermoformed container is carried out using a pump and a metering device, directly into the thermoformed packaging container.
Un volume d'environ 60 ml de la composition d'hydrogel est versé au fond du récipient thermoformé pour former une couche homogène d'une épaisseur d'environ 0,5 mm. Cette dernière se répartie de façon égale autour des reliefs du récipient reproduisant la forme des yeux, du nez et de la bouche. A volume of about 60 ml of the hydrogel composition is poured into the bottom of the thermoformed container to form a homogeneous layer with a thickness of about 0.5 mm. The latter is distributed evenly around the reliefs of the container reproducing the shape of the eyes, nose and mouth.
Etape 3 : Choc thermique négatif Step 3: Negative thermal shock
Le récipient chargé de la composition d'hydrogel est ensuite translaté horizontalement sur le tapis roulant et passe dans un tunnel de refroidissement, dans lequel est puisé de l'air froid à une température négative (« - 4°C). Le passage dans le tunnel réfrigérant dure environ 10 secondes. The container loaded with the hydrogel composition is then translated horizontally on the conveyor belt and passes through a cooling tunnel, in which cold air is drawn at a negative temperature ("-4 ° C). The passage in the refrigerant tunnel takes about 10 seconds.
A la sortie du tunnel réfrigérant, la composition qui s'est brutalement refroidie, gélifie et forme un hydrogel qui épouse la paroi du récipient moulé, ayant la forme d'un masque. At the outlet of the cooling tunnel, the composition which has suddenly cooled, gels and forms a hydrogel which follows the wall of the molded container, having the shape of a mask.
Etape 4 : Remplissage du masque hydrogel avec une composition de principes actifs cosmétiques concentrée
Une composition cosmétique liquide est obtenue en mélangeant les ingrédients dans les proportions indiquées dans le tableau 2 ci-dessous, dans une seconde cuve propre. Step 4: Filling the hydrogel mask with a composition of concentrated cosmetic active ingredients A liquid cosmetic composition is obtained by mixing the ingredients in the proportions indicated in Table 2 below, in a second clean tank.
Tableau 2 : Table 2:
Composition de principes actifs cosmétiques Composition of cosmetic active ingredients
Cette composition a pour but d'hydrater la peau et de réduire les rides et les ridules dans le cadre d'un soin anti-âge. This composition aims to moisturize the skin and reduce wrinkles and fine lines as part of an anti-aging care.
Cette composition est préparée à température ambiante (<45°C). A l'aide d'une pompe et d'un doseur, un volume de 5 ml de cette composition de principes actifs concentrée est déposé sur l'hydrogel dans le récipient d'emballage. Très rapidement, la composition cosmétique se retrouve intégralement absorbée par l'hydrogel. This composition is prepared at ambient temperature (<45 ° C.). Using a pump and a dispenser, a volume of 5 ml of this concentrated active ingredient composition is deposited on the hydrogel in the packaging container. Very quickly, the cosmetic composition is found completely absorbed by the hydrogel.
On notera qu'avec une seule ligne de production, il est possible de prévoir différents concentrés de principes actifs préparés dans différentes cuves, en vue de produire des hydrogels ayant une finalité différente. It will be noted that with a single production line, it is possible to provide different concentrates of active ingredients prepared in different tanks, in order to produce hydrogels having a different purpose.
Etape 5 : Thermoscellage du récipient Step 5: Heat sealing the container
Toujours à l'intérieur de la pièce blanche et peu après que la composition d'actif ait été versée sur l'hydrogel, le récipient thermoformé contenant le masque hydrogel est operculé par thermoscellage. Le film
servant d'opercule est thermo-soudé au niveau de la bordure supérieure du récipient emballage en PVC sur tout le pourtour du masque, ainsi qu'au niveau du sommet des reliefs formant les yeux, le nez et la bouche. Le récipient étant ainsi fermé de manière hermétique et le masque hydrogel étant imprégné de la composition de principes actifs, celui-ci peut se conserver, notamment en présence d'un système conservateur approprié (ex : propytparaben, methylparaben et methylisothiazolinone), sans se dessécher ni se corrompre, pendant plus de 24 mois. 21 Utilisation du masque hydrogel Still inside the white room and shortly after the active composition has been poured onto the hydrogel, the thermoformed container containing the hydrogel mask is sealed by heat sealing. The film The lid is thermo-welded at the upper edge of the PVC packaging container around the entire circumference of the mask, and at the top of the reliefs forming the eyes, nose and mouth. The container thus being sealed and the hydrogel mask being impregnated with the active ingredient composition, it can be preserved, especially in the presence of a suitable preservative system (eg propytparaben, methylparaben and methylisothiazolinone), without drying out nor corrupt, for more than 24 months. 21 Using the hydrogel mask
Le masque hydrogel produit et conditionné dans l'exemple 1 ci- dessus, est sorti de son emballage individuel en retirant l'opercule. Après nettoyage de la peau, il est positionné sur le visage de la personne souhaitant se faire un soin anti-âge. The hydrogel mask produced and packaged in Example 1 above, was removed from its individual package by removing the seal. After cleaning the skin, it is positioned on the face of the person wishing to make an anti-aging treatment.
Pour assurer un bon contact de l'hydrogel avec la surface de la peau, la personne applique le masque pour qu'il épouse parfaitement la forme de son visage. To ensure a good contact of the hydrogel with the surface of the skin, the person applies the mask so that it perfectly matches the shape of his face.
Le masque est laissé en place pendant environ 20 minutes, permettant aux principes actifs contenus dans l'hydrogel de pénétrer dans la peau (couches supérieures du stratum corneum). The mask is left in place for about 20 minutes, allowing the active ingredients in the hydrogel to penetrate the skin (upper layers of the stratum corneum).
Lorsque le masque est retiré, la personne élimine le surplus de liquide à la surface de sa peau à l'aide d'un mouchoir en papier. When the mask is removed, the person removes the excess liquid on the surface of his skin using a tissue paper.
3/ Test d'efficacité du masque hydrogel 3 / Hydrogel mask efficacy test
Objectifs des tests Objectives of the tests
L'objectif de cette étude a été d'évaluer les effets sur le relief cutané du produit "Masque Crystale de Collagena" (nom commercial donné au masque produit dans l'exemple 1 ci-dessus) après une application unique selon l'exemple 2, et après 28 jours d'utilisation, ainsi que l'appréciation subjective de ses caractéristiques organoleptiques et de son efficacité après 28 jours d'utilisation.
Etude des variations des paramètres du relief cutané The objective of this study was to evaluate the effects on the skin relief of the product "Collagena Crystalline Mask" (commercial name given to the mask produced in Example 1 above) after a single application according to Example 2 and after 28 days of use, as well as the subjective appreciation of its organoleptic characteristics and its effectiveness after 28 days of use. Study of the variations of the parameters of the cutaneous relief
Une étude des variations des paramètres du relief cutané (rugosité moyenne Ra, relief médian R3z, amplitude maximale Rt, relief moyen Rz,) à l'aide du système 3D PRIMOS® Compact (Phaseshift Rapid In vivo Measurement Of Skin - GF Messtechnik GmbH - 14513 BERLIN - Allemagne) a été effectuée directement in vivo. A study of the variations of the parameters of the cutaneous relief (average roughness Ra, median relief R3z, maximum amplitude Rt, average relief Rz,) using the 3D PRIMOS® Compact system (Phaseshift Rapid In vivo Measurement Of Skin - GF Messtechnik GmbH - 14513 BERLIN - Germany) was performed directly in vivo.
Cette technique consiste à calculer une image de phase à partir d'images de projection de franges d'interférence. Cette image permet de remonter à l'altitude de chaque point. This technique consists of calculating a phase image from interference fringe projection images. This image makes it possible to go back to the altitude of each point.
Le logiciel d'acquisition permet ensuite d'obtenir des mesures 2D et The acquisition software then makes it possible to obtain 2D measurements and
3D, et de déterminer les paramètres du relief cutané sur 32 profils répartis en étoile sur la zone d'intérêt. Un système de repositionnement automatique permet la réidentification précise de la zone de mesure. 3D, and determine the parameters of the cutaneous relief on 32 profiles distributed in star on the zone of interest. An automatic repositioning system allows precise re-identification of the measurement area.
Les paramètres exploités sur chaque profil (l'analyse porte sur la moyenne des 32 profils) ont été les suivants : The parameters used on each profile (the analysis focuses on the average of the 32 profiles) were as follows:
- Ra : rugosité moyenne (en pm). - Ra: average roughness (in pm).
La rugosité moyenne se définit comme le rapport de la surface intégrée autour de la valeur moyenne sur la longueur du profil. Une diminution de Ra traduit un effet lissant. Average roughness is defined as the ratio of the integrated area around the average value over the length of the profile. A decrease in Ra reflects a smoothing effect.
- R3z: le relief médian (en pm). - R3z: the median relief (in pm).
Le relief médian valeur correspond à la moyenne des cinq maxima du relief médian (distance verticale à partir du troisième pic le plus haut et du troisième creux le plus profond). Une diminution de R3z traduit un effet tenseur après une application standardisée d'un produit et un effet anti- ridules lors d'une utilisation prolongée. The median relief value is the average of the five maxima of the median relief (vertical distance from the third highest peak and the third deepest hollow). A decrease in R3z reflects a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
- Rz: le relief moyen (en pm). - Rz: the average relief (in pm).
Le relief moyen correspond à la valeur moyenne de tous les maxima (entre pic et creux) sur la longueur du profil. Une diminution de Rz traduit un effet tenseur après une application standardisée d'un produit et un effet anti- rides lors d'une utilisation prolongée. The average relief is the average value of all maxima (between peak and trough) over the length of the profile. A decrease in Rz reflects a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
- Rt: l'amplitude (en pm) : il s'agît de la valeur moyenne des cinq plus grands maxima (entre pic et creux) sur la longueur du profil. Une diminution
de Rt traduit un effet tenseur après une application standardisée d'un produit et un effet anti-rides lors d'une utilisation prolongée. - Rt: the amplitude (in pm): it is about the average value of the five largest maxima (between peak and hollow) on the length of the profile. A decrease of Rt translates a tightening effect after a standardized application of a product and an anti-wrinkle effect during prolonged use.
Les résultats obtenus ont été reportés dans le tableau 3 ci-après : The results obtained have been reported in Table 3 below:
Tableau 3 Table 3
Variation des paramètres du relief cutané 5 minutes après une application unique standardisée Variation of the parameters of the cutaneous relief 5 minutes after a standardized single application
en comparaison à l'état initial in comparison to the initial state
Il ressort du tableau 3 que 5 minutes après une application unique standardisée, le produit "Masque Crystale de Collagena" a induit : It can be seen from Table 3 that 5 minutes after a standardized single application, the product "Collagena Crystalline Mask" induced:
• une diminution significative de la rugosité moyenne (Ra) de -4,1 pm en moyenne, soit -13%. • a significant decrease in average roughness (Ra) of -4.1 pm on average, or -13%.
Un effet lissant a été observé chez 86% des volontaires. A smoothing effect was observed in 86% of the volunteers.
• une diminution significative du relief médian (R3z) de -7,3 pm en moyenne, soit - 0%. • a significant decrease in the median relief (R3z) of -7.3 pm on average, ie -0%.
• une diminution significative de l'amplitude du relief (Rt) de -27,6 pm en moyenne, soit -9%. • a significant decrease in the amplitude of the relief (Rt) of -27.6 pm on average, ie -9%.
• une diminution significative du relief moyen (Rz) de -20,8 pm en moyenne, soit -12%. • a significant decrease in average relief (Rz) of -20.8 pm on average, ie -12%.
Un effet tenseur/liftant a été observé chez 68 à 82% des volontaires.
Analyse des réponses données par les volontaires au questionnaire d'évaluation subjective. A tightening / lifting effect was observed in 68 to 82% of the volunteers. Analysis of the answers given by the volunteers to the subjective evaluation questionnaire.
Un questionnaire d'évaluation subjective, préparé par le centre d'essais cliniques a été rempli par 22 volontaires en fin d'étude afin d'évaluer subjectivement les caractéristiques du produit étudié, ainsi que son efficacité globale. A subjective evaluation questionnaire, prepared by the clinical trial center, was completed by 22 volunteers at the end of the study in order to subjectively evaluate the characteristics of the studied product, as well as its overall effectiveness.
La synthèse des réponses des volontaires est présentée dans les tableaux 4, 5 et 6 ci-dessous. The synthesis of volunteers' responses is presented in Tables 4, 5 and 6 below.
Pour plus de lisibilité, les pourcentages ont été arrondis à une unité près. La somme des pourcentages peut par conséquent être différente de 100%. Dans le cadre de cette étude (n=22), un volontaire est représenté par 4,5%. For greater clarity, the percentages have been rounded to one unit. The sum of the percentages can therefore be different from 100%. In this study (n = 22), a volunteer is represented by 4.5%.
Tableau 4 Table 4
Appréciation globale et caractéristiques organoleptiques du produit Overall appreciation and organoleptic characteristics of the product
Efficacité immédiate du produit Immediate effectiveness of the product
Sensation de fraîcheur 86% Sensation of freshness 86%
Sensation d'effet hydratant 95% Moisturizing effect sensation 95%
Sensation d'effet tenseur/liftant après application 86%
Tableau 6 Feeling of tensor / lift effect after application 86% Table 6
Efficacité du produit après 28 jours Efficacy of the product after 28 days
Dans les conditions expérimentales retenues, le produit "Masque In the experimental conditions selected, the product "Mask
Crystaie de Collagena" a induit un effet lissant et tenseur immédiatement après une application unique standardisée. Crystaie de Collagena "induced a smoothing and tensing effect immediately after a single standardized application.
Il a, en outre, satisfait globalement l'ensemble des volontaires pour : In addition, it has globally satisfied all volunteers for:
- ses caractéristiques organoleptiques : aspect, texture et parfum agréables. - its organoleptic characteristics: pleasant appearance, texture and fragrance.
- son efficacité immédiate : sensation de fraîcheur, d'effet hydratant et d'effet tenseur/liftant. - its immediate effectiveness: feeling of freshness, moisturizing effect and lifting / lifting effect.
- son efficacité après 28 jours d'utilisation : peau hydratée, douce, souple, lumineuse, plus jeune, effet relaxant/déstressant et sensation de détente.
- its effectiveness after 28 days of use: hydrated skin, soft, supple, luminous, younger, relaxing / de-stressing effect and relaxing sensation.
Claims
1 . Une composition d'hydrogel destinée à être appliquée sur la peau, caractérisée en ce qu'elle comprend un complexe gélifiant et épaississant comprenant de la carraghénane, du glucomannane et du galactomannane. 1. A hydrogel composition for application to the skin characterized by comprising a gelling and thickening complex comprising carrageenan, glucomannan and galactomannan.
2. Une composition d'hydrogel selon la revendication précédente, caractérisée en ce que le galactomannane est présent sous la forme de gomme de caroube. 2. A hydrogel composition according to the preceding claim, characterized in that the galactomannan is present in the form of locust bean gum.
3. Une composition d'hydrogel selon l'une des revendications précédentes, caractérisée en ce que ledit complexe gélifiant et épaississant comprend entre 0,2 et 2 % de carraghénane en poids hydraté de ladite composition, entre 0,2 et 2 % de glucommanane en poids hydraté de ladite composition, et entre 0,2 et 2 % de galactomannane en poids hydraté de ladite composition. 3. A hydrogel composition according to one of the preceding claims, characterized in that said gelling and thickening complex comprises between 0.2 and 2% carrageenan by hydrated weight of said composition, between 0.2 and 2% glucommanane. by hydrated weight of said composition, and between 0.2 and 2% of galactomannan by hydrated weight of said composition.
4. Une composition d'hydrogel selon l'une des revendications précédentes, caractérisée en ce qu'elle comprend, en outre, entre 0,1 et 1 % de citrate de potassium en poids hydraté de ladite composition. 4. A hydrogel composition according to one of the preceding claims, characterized in that it comprises, in addition, between 0.1 and 1% of potassium citrate by hydrated weight of said composition.
5. Une composition d'hydrogel selon l'une des revendications précédentes, caractérisée en ce qu'elfe comprend en outre entre 1 et 5 % de glycérol en poids hydraté de ladite composition. 5. A hydrogel composition according to one of the preceding claims, characterized in that ele further comprises between 1 and 5% glycerol by hydrated weight of said composition.
6. Procédé de préparation et de conditionnement d'un hydrogel destiné à être appliqué sur la peau, caractérisé en ce qu'il comprend les étapes suivantes : 6. A process for preparing and conditioning a hydrogel intended to be applied to the skin, characterized in that it comprises the following steps:
i) on prépare une composition d'hydrogel selon l'une des revendications 1 à 5; ii) on coule cette composition d'hydrogel à l'état liquide ou semi- liquide dans un récipient moulé afin de former une couche d'une épaisseur moyenne comprise entre 0,2 et 1 ,2 mm, de préférence entre 0,4 et 1 mm, au fond dudit récipient; i) preparing a hydrogel composition according to one of claims 1 to 5; ii) pouring said hydrogel composition in a liquid or semi-liquid state into a molded container to form a layer having an average thickness of between 0.2 and 1.2 mm, preferably between 0.4 and 1 mm at the bottom of said container;
iii) on soumet ladite composition dans son récipient moulé, à un choc thermique négatif de sorte à ce que ladite composition d'hydrogel gélifie au contact de la paroi du récipient moulé, iv) on verse sur l'hydrogel formé à l'étape iii) dans ledit récipient moulé, une composition liquide comprenant au moins un principe actif cosmétique ou pharmaceutique, de préférence sous forme concentrée ; iii) subjecting said composition in its molded container, to a negative thermal shock so that said hydrogel composition gels in contact with the wall of the molded container, iv) poured on the hydrogel formed in step iii ) in said molded container, a liquid composition comprising at least one cosmetic or pharmaceutical active ingredient, preferably in concentrated form;
v) on scelle hermétiquement ledit récipient contenant l'hydrogel et la composition de principe actif. v) hermetically sealing said container containing the hydrogel and the active ingredient composition.
7. Procédé selon la revendication 6, caractérisé en ce que la composition comprenant au moins un principe actif cosmétique ou pharmaceutique versée à l'étape iv) est concentrée et représente moins de 10 % du volume de la composition d'hydrogel. 7. Method according to claim 6, characterized in that the composition comprising at least one cosmetic or pharmaceutical active ingredient poured in step iv) is concentrated and represents less than 10% of the volume of the hydrogel composition.
8. Procédé selon l'une des revendications 6 et 7, caractérisé en ce que la composition de principe actif cosmétique comprend entre 1 et 5 % d'hydrolysat de collagène, entre 0,3 et 5 % de glucane d'avoine et entre 0,2 et 1 % d'acide hyaluronique. 8. Method according to one of claims 6 and 7, characterized in that the composition of the active cosmetic ingredient comprises between 1 and 5% of collagen hydrolyzate, between 0.3 and 5% of oat glucan and between 0 , 2 and 1% hyaluronic acid.
9. Procédé selon l'une des revendications 6 à 8, caractérisé en ce que la composition de principe actif cosmétique comprend au moins un des principes actifs suivants : papaïne, aloe vera, extraits de Glycyrrhiza ou de Scutellaria baicalensis. 9. Method according to one of claims 6 to 8, characterized in that the cosmetic active ingredient composition comprises at least one of the following active ingredients: papain, aloe vera, extracts of Glycyrrhiza or Scutellaria baicalensis.
10. Procédé selon l'une des revendications 6 à 9, caractérisé en ce que la composition de principe actif cosmétique comprend un parfum. 10. Method according to one of claims 6 to 9, characterized in that the cosmetic active ingredient composition comprises a perfume.
11. Procédé selon l'une des revendications 6 à 10, caractérisé en ce que le récipient moulé est scellé hermétiquement à l'étape v) par thermosoudure. 11. Method according to one of claims 6 to 10, characterized in that the molded container is hermetically sealed in step v) by heat sealing.
12. Kit pharmaceutique ou cosmétique susceptible d'être obtenu selon le procédé de l'une des revendications 1 à 6, caractérisé en ce qu'il comprend un hydroge! d'une épaisseur moyenne comprise entre 0,2 et 1,2 mm, de préférence inférieure à 1 mm, ledit hydrogel étant chargé d'une composition comprenant au moins un principe actif cosmétique ou pharmaceutique, et ledit hydrogel étant contenu dans un récipient moulé scellé hermétiquement. 12. Pharmaceutical or cosmetic kit obtainable according to the method of one of claims 1 to 6, characterized in that it comprises a hydrogen! of an average thickness of between 0.2 and 1.2 mm, preferably less than 1 mm, said hydrogel being loaded with a composition comprising at least one cosmetic or pharmaceutical active ingredient, and said hydrogel being contained in a molded container hermetically sealed.
13. Kit pharmaceutique ou cosmétique selon la revendication 12, caractérisé en ce que ledit hydrogel a la forme d'un masque. 13. Pharmaceutical or cosmetic kit according to claim 12, characterized in that said hydrogel is in the form of a mask.
14. Kit pharmaceutique ou cosmétique selon la revendication 12, caractérisé en ce que ledit hydrogel a la forme d'un patch. 14. Pharmaceutical or cosmetic kit according to claim 12, characterized in that said hydrogel is in the form of a patch.
15. Soin cosmétique, caractérisé en ce qu'on applique sur la peau, de préférence le visage, un hydrogel formé d'une composition d'hydrogel selon l'une quelconque des revendications 1 à 5. 15. Cosmetic treatment, characterized in that is applied to the skin, preferably the face, a hydrogel formed of a hydrogel composition according to any one of claims 1 to 5.
16. Soin cosmétique, caractérisé en ce qu'on applique sur la peau, de préférence le visage, un hydrogel obtenu et conditionné selon le procédé de l'une quelconque des revendications 6 à 11. 16. Cosmetic treatment, characterized in that a hydrogel obtained and packaged according to the method of any one of Claims 6 to 11 is applied to the skin, preferably the face.
Applications Claiming Priority (2)
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FR1056639A FR2963888B1 (en) | 2010-08-17 | 2010-08-17 | PROCESS FOR THE PREPARATION AND PACKAGING OF A COSMETIC OR PHARMACEUTICAL HYDROGEL FOR APPLICATION TO SKIN |
FR1056639 | 2010-08-17 |
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WO2012022858A1 true WO2012022858A1 (en) | 2012-02-23 |
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PCT/FR2011/000456 WO2012022858A1 (en) | 2010-08-17 | 2011-08-03 | Method for preparing and packaging a cosmetic pharmaceutical hydrogel to be applied to the skin |
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WO2016179269A1 (en) * | 2015-05-04 | 2016-11-10 | Makefield Llc | Ascorbic acid and biopolymer cosmetic compositions |
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FR3102485B1 (en) | 2019-10-23 | 2021-11-26 | Univ Paris Sud | BIODEGRADABLE STRETCH FILM |
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JP2005320264A (en) * | 2004-05-06 | 2005-11-17 | Daiya Seiyaku Kk | Gel base for external use and padding material filled in container |
WO2008072817A1 (en) | 2006-12-14 | 2008-06-19 | Fineco Ltd. | Hydrogel mask pack, method of preparing the same, and related composition |
KR100853301B1 (en) * | 2007-04-13 | 2008-08-21 | 주식회사 제닉 | Hydrogel composition having function for prevention of water release and molded object comprising the same |
WO2009024275A1 (en) * | 2007-08-20 | 2009-02-26 | Ics Innovative Care Systems Andernach Gmbh | Water- and active ingredient-containing gel |
EP2210583A1 (en) * | 2007-10-31 | 2010-07-28 | FUJIFILM Corporation | Gel sheet and cosmetic preparation in sheet form using the same |
US20100055161A1 (en) | 2008-08-27 | 2010-03-04 | Dong June Ahn | Hydrogel face mask for delivering skin care agents |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2016179269A1 (en) * | 2015-05-04 | 2016-11-10 | Makefield Llc | Ascorbic acid and biopolymer cosmetic compositions |
Also Published As
Publication number | Publication date |
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FR2963888A1 (en) | 2012-02-24 |
FR2963888B1 (en) | 2013-04-05 |
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