WO2012021707A3 - Premature-termination-codons readthrough compounds - Google Patents

Premature-termination-codons readthrough compounds Download PDF

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Publication number
WO2012021707A3
WO2012021707A3 PCT/US2011/047421 US2011047421W WO2012021707A3 WO 2012021707 A3 WO2012021707 A3 WO 2012021707A3 US 2011047421 W US2011047421 W US 2011047421W WO 2012021707 A3 WO2012021707 A3 WO 2012021707A3
Authority
WO
WIPO (PCT)
Prior art keywords
codons
premature
termination
readthrough
compounds
Prior art date
Application number
PCT/US2011/047421
Other languages
French (fr)
Other versions
WO2012021707A2 (en
Inventor
Richard A. Gatti
Liutao Du
Robert Damoiseaux
Chih-Hung Lai
Michael Jung
Jin-Mo Ku
Carmen Bertoni
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of WO2012021707A2 publication Critical patent/WO2012021707A2/en
Publication of WO2012021707A3 publication Critical patent/WO2012021707A3/en
Priority to US13/764,748 priority Critical patent/US9255088B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Radiation-Therapy Devices (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
PCT/US2011/047421 2010-08-11 2011-08-11 Premature-termination-codons readthrough compounds WO2012021707A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/764,748 US9255088B2 (en) 2010-08-11 2013-02-11 Premature-termination-codons readthrough compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37276810P 2010-08-11 2010-08-11
US61/372,768 2010-08-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/764,748 Continuation US9255088B2 (en) 2010-08-11 2013-02-11 Premature-termination-codons readthrough compounds

Publications (2)

Publication Number Publication Date
WO2012021707A2 WO2012021707A2 (en) 2012-02-16
WO2012021707A3 true WO2012021707A3 (en) 2012-05-10

Family

ID=45568191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/047421 WO2012021707A2 (en) 2010-08-11 2011-08-11 Premature-termination-codons readthrough compounds

Country Status (1)

Country Link
WO (1) WO2012021707A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109248A1 (en) * 2014-01-16 2015-07-23 The Regents Of The University Of California Read-through compound prodrugs suppressing premature nonsense mutations
CN104059060B (en) * 2014-05-30 2017-08-01 西安交通大学 A kind of ketones derivant of 5 (methylene of 1H indoles 3) 1,3 thiazolidine 4 and its synthetic method and application
WO2017049409A1 (en) * 2015-09-25 2017-03-30 The Centre For Drug Research And Development Compositions for promoting readthrough of premature termination codons, and methods of using the same
PL3877052T3 (en) 2018-11-06 2024-02-05 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EA202191084A1 (en) 2018-11-06 2021-10-19 Эджвайз Терапьютикс, Инк. COMPOUNDS OF PYRIDAZINONES AND THEIR APPLICATIONS
JP2022506686A (en) * 2018-11-06 2022-01-17 エッジワイズ セラピューティクス， インコーポレイテッド Pyridadinone compounds and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008317A1 (en) * 1999-12-14 2003-01-09 Tularik Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US20090093418A1 (en) * 2006-04-03 2009-04-09 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008317A1 (en) * 1999-12-14 2003-01-09 Tularik Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US20090093418A1 (en) * 2006-04-03 2009-04-09 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIUTAO DU ET AL.: "Nonaminoglycoside compounds induce read through of nonsense mutations", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 206, no. 10, September 2009 (2009-09-01), pages 2285 - 2297 *
LIUTAO DU ET AL.: "Rapid screen for truncating ATM mutations by PTT-ELISA", MUTATION RESEARCH, vol. 640, no. 1-2, 31 January 2008 (2008-01-31), pages 139 - 144, XP022527908, DOI: doi:10.1016/j.mrfmmm.2008.01.002 *

Also Published As

Publication number Publication date
WO2012021707A2 (en) 2012-02-16

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