WO2012020985A3 - Method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry - Google Patents

Method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry Download PDF

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Publication number
WO2012020985A3
WO2012020985A3 PCT/KR2011/005843 KR2011005843W WO2012020985A3 WO 2012020985 A3 WO2012020985 A3 WO 2012020985A3 KR 2011005843 W KR2011005843 W KR 2011005843W WO 2012020985 A3 WO2012020985 A3 WO 2012020985A3
Authority
WO
WIPO (PCT)
Prior art keywords
aspirin
analyzing
plasma
mass spectrometry
liquid chromatography
Prior art date
Application number
PCT/KR2011/005843
Other languages
French (fr)
Other versions
WO2012020985A2 (en
Inventor
Eun Young Kim
Han Kyong Kim
Eun Young Lee
Original Assignee
Hanmi Holdings Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Holdings Co., Ltd. filed Critical Hanmi Holdings Co., Ltd.
Publication of WO2012020985A2 publication Critical patent/WO2012020985A2/en
Publication of WO2012020985A3 publication Critical patent/WO2012020985A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The present invention relates to a method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry, which can stably and easily analyze ASA and SA without loss of their amounts even after sampling.
PCT/KR2011/005843 2010-08-10 2011-08-10 Method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry WO2012020985A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0076890 2010-08-10
KR1020100076890A KR20120014736A (en) 2010-08-10 2010-08-10 Method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry

Publications (2)

Publication Number Publication Date
WO2012020985A2 WO2012020985A2 (en) 2012-02-16
WO2012020985A3 true WO2012020985A3 (en) 2012-05-31

Family

ID=45568044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/005843 WO2012020985A2 (en) 2010-08-10 2011-08-10 Method for analyzing aspirin in plasma with liquid chromatography-mass spectrometry

Country Status (2)

Country Link
KR (1) KR20120014736A (en)
WO (1) WO2012020985A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101495450B1 (en) * 2013-11-22 2015-03-02 한국마사회 A method for analysis of acidic drugs in equine blood sample using on-column methylation
KR102033857B1 (en) 2018-05-30 2019-10-17 경상대학교산학협력단 Method for increasing the amino acid recovery of serum or plasma and Analytical method for determination of free amino acid in serum or plasma using LC-MS/MS
CN109085262A (en) * 2018-08-03 2018-12-25 杭州佰勤医疗器械有限公司 Serum plasma pharmaceutical extraction composition and application thereof
CN112485340A (en) * 2019-11-27 2021-03-12 南京品生医学检验实验室有限公司 Method for detecting 1, 5-sorbitan in plasma by ultra-high performance liquid chromatography tandem mass spectrometry
CN112345683A (en) * 2020-11-24 2021-02-09 辽宁药联制药有限公司 LC-MS simultaneous determination of ligustrazine and aspirin in blood plasma
CN114778737B (en) * 2022-04-27 2024-05-10 天津国科医疗科技发展有限公司 Liquid chromatography detection sample pretreatment method capable of shortening time

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALANO, M. A. ET AL.: "Analysis of nonsteroidal anti-inflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn", PEDIATRICS, vol. 107, 1 March 2001 (2001-03-01), pages 519 - 523 *
BAE, S. K. ET AL.: "Determination of acetylsalicylic acid and its major metabolite, salicylic acid, in human plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study of Astrix in Korean healthy volunteers", BIOMEDICAL CHROMATOGRAPHY, vol. 22, 6 February 2008 (2008-02-06), pages 590 - 595 *
GENTILI, A.: "Determination of non-steroidal anti-inflammatory drugs in environmental samples by chromatographic and electrophoretic techniques", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 387, 1 December 2006 (2006-12-01), pages 1185 - 1202, XP019488755 *
LEE, H.-B. ET AL.: "Acidic pharmaceuticals in sewage-methodology stability test, occurrence, and removal from Ontario samples", WATER QUALITY RESEARCH JOURNAL OF CANADA, vol. 38, 31 December 2003 (2003-12-31), pages 667 - 682 *
VERENITCH, S. S. ET AL.: "Determination of acidic drugs and caffeine in municipal wastewaters and receiving waters by gas chromatography-ion trap tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY A, vol. 1116, 20 March 2006 (2006-03-20), pages 193 - 203, XP024967392, DOI: doi:10.1016/j.chroma.2006.03.005 *

Also Published As

Publication number Publication date
KR20120014736A (en) 2012-02-20
WO2012020985A2 (en) 2012-02-16

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