WO2012019192A3 - Cell-permeable molecules as growth factor receptor antagonists - Google Patents

Cell-permeable molecules as growth factor receptor antagonists Download PDF

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Publication number
WO2012019192A3
WO2012019192A3 PCT/US2011/046956 US2011046956W WO2012019192A3 WO 2012019192 A3 WO2012019192 A3 WO 2012019192A3 US 2011046956 W US2011046956 W US 2011046956W WO 2012019192 A3 WO2012019192 A3 WO 2012019192A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
factor receptor
cell
molecules
receptor antagonists
Prior art date
Application number
PCT/US2011/046956
Other languages
French (fr)
Other versions
WO2012019192A2 (en
Inventor
Ravi Iyengar
Aislyn Dara Wist Boran
Yibang Chen
Original Assignee
Mount Sinai School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai School Of Medicine filed Critical Mount Sinai School Of Medicine
Publication of WO2012019192A2 publication Critical patent/WO2012019192A2/en
Publication of WO2012019192A3 publication Critical patent/WO2012019192A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides growth factor receptor inhibitory molecules and methods of identifying such molecules, as well as methods of making such molecules and methods of using such molecules, for example in the treatment of cancer such as breast, colorectal, pancreatic, or lung cancer.
PCT/US2011/046956 2010-08-06 2011-08-08 Cell-permeable molecules as growth factor receptor antagonists WO2012019192A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37158910P 2010-08-06 2010-08-06
US61/371,589 2010-08-06
US201161454209P 2011-03-18 2011-03-18
US61/454,209 2011-03-18

Publications (2)

Publication Number Publication Date
WO2012019192A2 WO2012019192A2 (en) 2012-02-09
WO2012019192A3 true WO2012019192A3 (en) 2012-05-03

Family

ID=45560114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/046956 WO2012019192A2 (en) 2010-08-06 2011-08-08 Cell-permeable molecules as growth factor receptor antagonists

Country Status (1)

Country Link
WO (1) WO2012019192A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015515282A (en) 2012-04-25 2015-05-28 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント Compositions and methods for wound healing and tissue repair

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. BARDELLI ET AL: "Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 95, no. 24, 24 November 1998 (1998-11-24), pages 14379 - 14383, XP055012290, ISSN: 0027-8424, DOI: 10.1073/pnas.95.24.14379 *
ANONYMOUS: "EGFR (Epidermal Growth Factor Receptor) inhibitor: Petide Antagonists targeting Juxtamembrane.", 23 July 2009 (2009-07-23), XP002663757, Retrieved from the Internet <URL:http://mssm.technologypublisher.com/technology/3228> [retrieved on 20111116] *
CHRISTENSEN J G ET AL: "c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention", CANCER LETTERS, vol. 225, no. 1, 8 July 2005 (2005-07-08), NEW YORK, NY, US, pages 1 - 26, XP027608071, ISSN: 0304-3835, [retrieved on 20050708] *
HOOSHMAND RAD ET AL: "PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells.", JOURNAL OF CELL SCIENCE, vol. 111, no. 5, 1 March 1998 (1998-03-01), pages 607 - 614, XP055012379, ISSN: 0021-9533 *
JAE-HO LEE ET AL: "A novel germ line juxtamembrane Met mutation in human gastric cancer", ONCOGENE, vol. 19, no. 43, 1 January 2000 (2000-01-01), pages 4947 - 4953, XP055012366, ISSN: 0950-9232, DOI: 10.1038/sj.onc.1203874 *
P. M. CHAN ET AL: "Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region", MOLECULAR AND CELLULAR BIOLOGY, vol. 23, no. 9, 1 May 2003 (2003-05-01), pages 3067 - 3078, XP055012332, ISSN: 0270-7306, DOI: 10.1128/MCB.23.9.3067-3078.2003 *

Also Published As

Publication number Publication date
WO2012019192A2 (en) 2012-02-09

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