WO2012019049A1 - Devices, systems, and methods for excavating cancer cells - Google Patents
Devices, systems, and methods for excavating cancer cells Download PDFInfo
- Publication number
- WO2012019049A1 WO2012019049A1 PCT/US2011/046653 US2011046653W WO2012019049A1 WO 2012019049 A1 WO2012019049 A1 WO 2012019049A1 US 2011046653 W US2011046653 W US 2011046653W WO 2012019049 A1 WO2012019049 A1 WO 2012019049A1
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- WO
- WIPO (PCT)
- Prior art keywords
- tumor
- migration
- nanofibers
- tumor cells
- substrate
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2011285639A AU2011285639B2 (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
JP2013523347A JP5894989B2 (en) | 2010-08-04 | 2011-08-04 | Apparatus, system, and method for extracting cancer cells |
CA2807483A CA2807483C (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
EP11815346.9A EP2600792B1 (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
US13/814,009 US11273250B2 (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37063010P | 2010-08-04 | 2010-08-04 | |
US61/370,630 | 2010-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012019049A1 true WO2012019049A1 (en) | 2012-02-09 |
Family
ID=45559831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/046653 WO2012019049A1 (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
Country Status (6)
Country | Link |
---|---|
US (1) | US11273250B2 (en) |
EP (2) | EP2600792B1 (en) |
JP (1) | JP5894989B2 (en) |
AU (1) | AU2011285639B2 (en) |
CA (1) | CA2807483C (en) |
WO (1) | WO2012019049A1 (en) |
Cited By (24)
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WO2013134352A1 (en) * | 2012-03-06 | 2013-09-12 | The Uab Research Foundation | Aligned nanofibrous structures for axonal regeneration after spinal cord injury or surgery |
EP2714073A1 (en) * | 2011-06-03 | 2014-04-09 | President and Fellows of Harvard College | In situ antigen-generating cancer vaccine |
WO2014083019A2 (en) * | 2012-11-27 | 2014-06-05 | Sergas | Agent, product and use |
US9132210B2 (en) | 2005-12-13 | 2015-09-15 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
US9297005B2 (en) | 2009-04-13 | 2016-03-29 | President And Fellows Of Harvard College | Harnessing cell dynamics to engineer materials |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
US9381235B2 (en) | 2009-07-31 | 2016-07-05 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
US9610328B2 (en) | 2010-03-05 | 2017-04-04 | President And Fellows Of Harvard College | Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1 |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
US9693954B2 (en) | 2010-06-25 | 2017-07-04 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
US9770535B2 (en) | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
US9821045B2 (en) | 2008-02-13 | 2017-11-21 | President And Fellows Of Harvard College | Controlled delivery of TLR3 agonists in structural polymeric devices |
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US9937249B2 (en) | 2012-04-16 | 2018-04-10 | President And Fellows Of Harvard College | Mesoporous silica compositions for modulating immune responses |
US10045947B2 (en) | 2011-04-28 | 2018-08-14 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
US10111935B2 (en) | 2014-04-30 | 2018-10-30 | Fundaciön Pedro Barrié De La Maza, Condo De Fenosa | Agent for capturing tumor cells and methods of use thereof |
US10647959B2 (en) | 2011-04-27 | 2020-05-12 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
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US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030017141A1 (en) * | 1999-04-08 | 2003-01-23 | Poznansky Mark C. | Purposeful movement of human migratory cells away from an agent source |
WO2008137659A1 (en) * | 2007-05-04 | 2008-11-13 | University Of Virginia Patent Foundation | Compositions and methods for making and using laminin nanofibers |
US20100129418A1 (en) * | 2008-11-18 | 2010-05-27 | Lowell Jeffry Lawrence | Method of inducing negative chemotaxis using an ellagitannin or gallotannin |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2121286B (en) | 1982-06-02 | 1985-11-06 | Ethicon Inc | Improvements in synthetic vascular grafts, and methods of manufacturing such grafts |
US5217492A (en) | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
CA1233953A (en) | 1984-03-30 | 1988-03-15 | Robert D. Ainsworth | Orthopedic device and method of making the same |
US5053453A (en) | 1988-11-01 | 1991-10-01 | Baxter International Inc. | Thromboresistant materials and methods for making same |
USRE36370E (en) | 1992-01-13 | 1999-11-02 | Li; Shu-Tung | Resorbable vascular wound dressings |
US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
US6347930B1 (en) | 1997-09-11 | 2002-02-19 | Hospal R & D Int. | Device and method for manufacturing a segmented tubular capsule containing a biologically active medium |
US6165217A (en) | 1997-10-02 | 2000-12-26 | Gore Enterprise Holdings, Inc. | Self-cohering, continuous filament non-woven webs |
US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
JP4341049B2 (en) | 1998-06-05 | 2009-10-07 | オルガノジェネシス インク. | Tubular graft prosthesis made by biotechnology |
US20020081732A1 (en) | 2000-10-18 | 2002-06-27 | Bowlin Gary L. | Electroprocessing in drug delivery and cell encapsulation |
US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
US6716225B2 (en) | 2001-08-02 | 2004-04-06 | Collagen Matrix, Inc. | Implant devices for nerve repair |
US6893431B2 (en) | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
US7622299B2 (en) | 2002-02-22 | 2009-11-24 | University Of Washington | Bioengineered tissue substitutes |
US20030175410A1 (en) | 2002-03-18 | 2003-09-18 | Campbell Phil G. | Method and apparatus for preparing biomimetic scaffold |
US8337893B2 (en) | 2002-07-10 | 2012-12-25 | Florida Research Foundation, Inc, University Of | Sol-gel derived bioactive glass polymer composite |
US20050038498A1 (en) | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US7163920B2 (en) | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
US7704740B2 (en) | 2003-11-05 | 2010-04-27 | Michigan State University | Nanofibrillar structure and applications including cell and tissue culture |
US20060085063A1 (en) | 2004-10-15 | 2006-04-20 | Shastri V P | Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering |
WO2006096791A2 (en) | 2005-03-07 | 2006-09-14 | Georgia Tech Research Corporation | Nanofilament scaffold for tissue regeneration |
US7531503B2 (en) | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
CN101410508B (en) | 2006-01-27 | 2013-07-03 | 加利福尼亚大学董事会 | Biomimetic scaffolds |
US20080220042A1 (en) | 2006-01-27 | 2008-09-11 | The Regents Of The University Of California | Biomolecule-linked biomimetic scaffolds |
WO2008122044A2 (en) | 2007-04-02 | 2008-10-09 | Georgia Tech Research Corporation | Implantable device for communicating with biological tissue |
US9770535B2 (en) * | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
US20090043380A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Coatings for promoting endothelization of medical devices |
US20090082856A1 (en) * | 2007-09-21 | 2009-03-26 | Boston Scientific Scimed, Inc. | Medical devices having nanofiber-textured surfaces |
US8940331B2 (en) * | 2008-11-22 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogels, methods of making hydrogels, methods of using hydrogels, and methods of isolating, trapping, attracting, and/or killing cancer cells |
JP2012527217A (en) | 2009-04-24 | 2012-11-08 | ジ・オハイオ・ステート・ユニバーシティ | Bidirectional microenvironment system |
US20110038936A1 (en) | 2009-08-17 | 2011-02-17 | Kimberly Ann Griswold | System and method for electrospun drug loaded biodegradable chemotherapy applications |
US9572909B2 (en) | 2009-09-14 | 2017-02-21 | Virginia Commonwealth University | Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture |
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2011
- 2011-08-04 AU AU2011285639A patent/AU2011285639B2/en active Active
- 2011-08-04 EP EP11815346.9A patent/EP2600792B1/en active Active
- 2011-08-04 EP EP17199344.7A patent/EP3298986A1/en not_active Withdrawn
- 2011-08-04 US US13/814,009 patent/US11273250B2/en active Active
- 2011-08-04 CA CA2807483A patent/CA2807483C/en active Active
- 2011-08-04 WO PCT/US2011/046653 patent/WO2012019049A1/en active Application Filing
- 2011-08-04 JP JP2013523347A patent/JP5894989B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030017141A1 (en) * | 1999-04-08 | 2003-01-23 | Poznansky Mark C. | Purposeful movement of human migratory cells away from an agent source |
WO2008137659A1 (en) * | 2007-05-04 | 2008-11-13 | University Of Virginia Patent Foundation | Compositions and methods for making and using laminin nanofibers |
US20100129418A1 (en) * | 2008-11-18 | 2010-05-27 | Lowell Jeffry Lawrence | Method of inducing negative chemotaxis using an ellagitannin or gallotannin |
Non-Patent Citations (5)
Title |
---|
JOHNSON ET AL.: "Quantitative Analysis of Complex Glioma Cell Migration on Electrospun Polycaprolactone Using Time-Lapse Microscopy.", TISSUE ENGINEERING: PART C., vol. 15, 2009, pages 531 - 541, XP055083103 * |
LI ET AL.: "Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site.", NANO LETTERS, vol. 9, 2009, pages 2763 - 2768, XP055083107 * |
SCHWALL ET AL.: "Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering.", MATERIALS., vol. 2, 2009, pages 577 - 612, XP055083106 * |
See also references of EP2600792A4 * |
XIE ET AL.: "Electrospun Micro- and Nanofibers for Sustained Delivery of Paclitaxel to Treat C6 Glioma in Vitro.", PHARMACEUTICAL RESEARCH., vol. 23, 2006, pages 1817 - 1826, XP019405186 * |
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Also Published As
Publication number | Publication date |
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US20130172846A1 (en) | 2013-07-04 |
US11273250B2 (en) | 2022-03-15 |
AU2011285639A1 (en) | 2013-02-21 |
EP2600792B1 (en) | 2017-11-01 |
CA2807483C (en) | 2019-02-26 |
EP2600792A4 (en) | 2014-04-16 |
JP2013538079A (en) | 2013-10-10 |
EP2600792A1 (en) | 2013-06-12 |
EP3298986A1 (en) | 2018-03-28 |
JP5894989B2 (en) | 2016-03-30 |
AU2011285639B2 (en) | 2014-12-18 |
CA2807483A1 (en) | 2012-02-09 |
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