WO2012018241A3 - 치아를 이용한 골 이식재 가공방법 및 그에 의해 가공된 골 이식재 - Google Patents

치아를 이용한 골 이식재 가공방법 및 그에 의해 가공된 골 이식재 Download PDF

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Publication number
WO2012018241A3
WO2012018241A3 PCT/KR2011/005748 KR2011005748W WO2012018241A3 WO 2012018241 A3 WO2012018241 A3 WO 2012018241A3 KR 2011005748 W KR2011005748 W KR 2011005748W WO 2012018241 A3 WO2012018241 A3 WO 2012018241A3
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WIPO (PCT)
Prior art keywords
graft material
bone graft
tooth
powder
crown
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PCT/KR2011/005748
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English (en)
French (fr)
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WO2012018241A2 (ko
Inventor
엄인웅
Original Assignee
Um In Woong
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Publication date
Application filed by Um In Woong filed Critical Um In Woong
Priority to CN201180038594.XA priority Critical patent/CN103068415B/zh
Priority to JP2013523097A priority patent/JP2013535284A/ja
Priority to US13/814,001 priority patent/US20130143179A1/en
Priority to EP11814841.0A priority patent/EP2601982B1/en
Publication of WO2012018241A2 publication Critical patent/WO2012018241A2/ko
Publication of WO2012018241A3 publication Critical patent/WO2012018241A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3865—Dental/periodontal tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 발치된 치아를 부위 별로 구분하여 가공하여 치조골 이식이나 치조골 증강과 같은 이용 용도에 따라 부위 별 파우더를 독립적으로 또는 혼합하여 사용할 수 있도록 개선한 치아를 이용한 골 이식재 가공방법 및 그에 따른 골 이식재에 관한 것이며, 상기 골 이식재 가공방법은 (a) 환자로부터 발치된 치아를 치관과 치근의 경계면에서 절단하는 단계; (b) 수평 절단된 상기 치관의 결손 부위와 연조직 및 치수조직을 제거하는 단계; (c) 상기 치관 조직을 급속 냉동한 후 분쇄하여 평균입경 200 내지 1500 μm 입자 크기의 파우더로 만드는 단계; (d) 상기 파우더를 탈지하는 단계; (e) 상기 파우더를 탈수하는 단계; 및 (f) 탈지 및 탈수된 상기 파우더를 적어도 멸균을 포함하는 후처리를 수행하여 골 이식재로 제조하는 단계;를 포함한다.
PCT/KR2011/005748 2010-08-05 2011-08-05 치아를 이용한 골 이식재 가공방법 및 그에 의해 가공된 골 이식재 WO2012018241A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201180038594.XA CN103068415B (zh) 2010-08-05 2011-08-05 使用牙齿的骨移植材料的加工方法及由其加工的骨移植材料
JP2013523097A JP2013535284A (ja) 2010-08-05 2011-08-05 歯を利用した骨移植材の加工方法、及びそれにより加工された骨移植材（ｐｒｏｃｅｓｓｉｎｇｍｅｔｈｏｄｏｆａｎｂｏｎｅｇｒａｆｔｓｗｉｔｈｔｏｏｔｈａｎｄｔｈｅｂｏｎｅｇｒａｆｔｓｐｒｏｃｅｓｓｅｄｔｈｅｓａｍｅ）
US13/814,001 US20130143179A1 (en) 2010-08-05 2011-08-05 Method for processing bone graft material using teeth, and bone graft material processed thereby
EP11814841.0A EP2601982B1 (en) 2010-08-05 2011-08-05 Method for processing bone graft material using teeth, and bone graft material processed thereby

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0075400 2010-08-05
KR20100075400 2010-08-05

Publications (2)

Publication Number Publication Date
WO2012018241A2 WO2012018241A2 (ko) 2012-02-09
WO2012018241A3 true WO2012018241A3 (ko) 2012-05-18

Family

ID=45559938

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/005748 WO2012018241A2 (ko) 2010-08-05 2011-08-05 치아를 이용한 골 이식재 가공방법 및 그에 의해 가공된 골 이식재

Country Status (6)

Country Link
US (1) US20130143179A1 (ko)
EP (1) EP2601982B1 (ko)
JP (1) JP2013535284A (ko)
KR (1) KR101391420B1 (ko)
CN (1) CN103068415B (ko)
WO (1) WO2012018241A2 (ko)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
KR101524774B1 (ko) * 2012-07-23 2015-06-01 조선대학교산학협력단 자가치아 골 이식재 및 그 제조방법
KR102251719B1 (ko) * 2013-01-15 2021-05-14 코메타바이오 인코포레이티드 치아 골 이식편 제조 장치 및 방법
KR101386322B1 (ko) * 2013-02-14 2014-04-17 티비엠 주식회사 자가 치아 뼈 이식재의 가공방법
KR101382067B1 (ko) * 2013-02-14 2014-04-04 티비엠 주식회사 크라운 지지부를 갖는 자가 치아 이식재의 가공방법
WO2015186846A1 (ko) * 2014-06-02 2015-12-10 장재우 골이식용 이식물 및 이를 이용한 골이식 방법
US11291612B2 (en) 2019-12-10 2022-04-05 Rutgers, The State University Of New Jersey Injectable hybrid cement for dental implants and methods of manufacture thereof
EP3668445A4 (en) * 2017-08-14 2021-04-21 Rutgers, the State University of New Jersey PROCESSES FOR CUSTOMIZED DENTAL IMPLANTS CONTAINED FROM A BIOMIMETIC COMPOSITE MATERIAL AND THEIR MANUFACTURING PROCESSES
US11406478B2 (en) 2017-08-14 2022-08-09 Rutgers, The State University Of New Jersey Methods for customized dental implants formed of a biometric composite material and methods of manufacture thereof
JP2019063191A (ja) * 2017-09-29 2019-04-25 国立研究開発法人国立長寿医療研究センター 非細胞性根管充填材及び非細胞性歯組織再生促進キット
JP7446617B2 (ja) * 2018-07-20 2024-03-11 国立大学法人北海道大学 医療用膜材料
CN109172048A (zh) * 2018-08-20 2019-01-11 郭建群 一种恒牙提取物在制备下颌填充材料中的应用
CN110420354B (zh) * 2019-09-03 2022-08-02 杨兴华 一种增强型丝素蛋白人工颌骨载体支架及其制备方法
CN112716627B (zh) * 2020-11-25 2021-12-07 广州市弘健生物医用制品科技有限公司 一种基于超声波系统的牙槽骨重建套件
CN114795556B (zh) * 2022-05-10 2023-05-12 图斯邦柯生物科技(苏州)有限公司 离体牙骨储存和制备方法

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KR20040087438A (ko) * 2003-04-08 2004-10-14 김영균 동물 치아를 이용한 경조직 결손부 수복 및 이식재와 그제조방법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04114656A (ja) * 1990-09-06 1992-04-15 Tech Res & Dev Inst Of Japan Def Agency 骨誘導性脱灰歯牙物とその製造方法
KR20020011164A (ko) * 2000-08-01 2002-02-08 이건일 골이식 물질의 제조방법
KR20040087438A (ko) * 2003-04-08 2004-10-14 김영균 동물 치아를 이용한 경조직 결손부 수복 및 이식재와 그제조방법
KR20040065203A (ko) * 2004-07-03 2004-07-21 정필훈 발치된 치아로부터 치아 단백질의 추출방법과 그의 이용방법
KR20100040427A (ko) * 2008-10-10 2010-04-20 주식회사 코리아티슈뱅크 자기 치아를 이용한 치료방법 및 치아 처리방법

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CN103068415A (zh) 2013-04-24
EP2601982A2 (en) 2013-06-12
CN103068415B (zh) 2014-11-26
JP2013535284A (ja) 2013-09-12
US20130143179A1 (en) 2013-06-06
EP2601982B1 (en) 2015-04-08

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