WO2012016050A3 - Chemoradiotherapy for kras-mutant colorectal cancer - Google Patents
Chemoradiotherapy for kras-mutant colorectal cancer Download PDFInfo
- Publication number
- WO2012016050A3 WO2012016050A3 PCT/US2011/045735 US2011045735W WO2012016050A3 WO 2012016050 A3 WO2012016050 A3 WO 2012016050A3 US 2011045735 W US2011045735 W US 2011045735W WO 2012016050 A3 WO2012016050 A3 WO 2012016050A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- kras
- chemoradiotherapy
- colorectal cancer
- mutant colorectal
- mutant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
This invention relates to methods of treating KRAS-mutant cancers by administering a composition comprising Midostaurin (PKC-412), and methods for increasing the sensitivity of colorectal cancers to radiation, e.g., using Midostaurin (PKC-412) to radiosensitize colorectal cancers or cancer cells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36848210P | 2010-07-28 | 2010-07-28 | |
US61/368,482 | 2010-07-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012016050A2 WO2012016050A2 (en) | 2012-02-02 |
WO2012016050A3 true WO2012016050A3 (en) | 2012-05-24 |
Family
ID=45530722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/045735 WO2012016050A2 (en) | 2010-07-28 | 2011-07-28 | Chemoradiotherapy for kras-mutant colorectal cancer |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012016050A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015041837A1 (en) | 2013-09-19 | 2015-03-26 | The Research Foundation For The State University Of New York | Methods and materials for treating diabetes or liver steatosis |
JP2015096049A (en) * | 2013-11-15 | 2015-05-21 | 凸版印刷株式会社 | Method for predicting long-term success of vegf inhibitor |
AU2016243512A1 (en) * | 2015-03-27 | 2017-11-09 | The Research Foundation For The State University Of New York | Methods and materials for treating cancer |
WO2016160594A1 (en) | 2015-03-27 | 2016-10-06 | The Research Foundation For The State University Of New York | Methods and materials for reducing amyloid beta levels within a mammal |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3325104A (en) * | 1963-07-15 | 1967-06-13 | Hartford Machine Screw | Fuel injection nozzle |
US6543421B2 (en) * | 2000-03-21 | 2003-04-08 | Siemens Automotive Corporation | Fuel injector assembly for mounting a fuel injector to a fuel rail and permitting alignment of the fuel injector |
-
2011
- 2011-07-28 WO PCT/US2011/045735 patent/WO2012016050A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3325104A (en) * | 1963-07-15 | 1967-06-13 | Hartford Machine Screw | Fuel injection nozzle |
US6543421B2 (en) * | 2000-03-21 | 2003-04-08 | Siemens Automotive Corporation | Fuel injector assembly for mounting a fuel injector to a fuel rail and permitting alignment of the fuel injector |
Also Published As
Publication number | Publication date |
---|---|
WO2012016050A2 (en) | 2012-02-02 |
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