WO2012007531A3 - Methods and compositions for diagnosing medical conditions - Google Patents

Methods and compositions for diagnosing medical conditions Download PDF

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Publication number
WO2012007531A3
WO2012007531A3 PCT/EP2011/062006 EP2011062006W WO2012007531A3 WO 2012007531 A3 WO2012007531 A3 WO 2012007531A3 EP 2011062006 W EP2011062006 W EP 2011062006W WO 2012007531 A3 WO2012007531 A3 WO 2012007531A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyamines
derivatives
salts
medical condition
predisposition
Prior art date
Application number
PCT/EP2011/062006
Other languages
French (fr)
Other versions
WO2012007531A2 (en
Inventor
Frank Madeo
Tobias Eisenberg
Thomas Pieber
Christoph Magnes
Frank Sinner
Joris Winderickx
Gret Van Den Berghe
Jan Gunst
Original Assignee
Frank Madeo
Tobias Eisenberg
Thomas Pieber
Christoph Magnes
Frank Sinner
Joris Winderickx
Gret Van Den Berghe
Jan Gunst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Madeo, Tobias Eisenberg, Thomas Pieber, Christoph Magnes, Frank Sinner, Joris Winderickx, Gret Van Den Berghe, Jan Gunst filed Critical Frank Madeo
Publication of WO2012007531A2 publication Critical patent/WO2012007531A2/en
Publication of WO2012007531A3 publication Critical patent/WO2012007531A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Abstract

The present invention relates to a method for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop a non-infectious medical condition, comprising detecting and/or analyzing in a test sample derived from the subject one or more polyamines or one or more salts or derivatives thereof, wherein the presence of any one of the polyamines or the salts or derivatives thereof in the test sample is indicative of the medical condition or a predisposition to develop the medical condition. In particular embodiments, the method further comprises quantifying the levels of the one or more polyamines or the one or more salts or derivatives thereof in the test sample, wherein an altered level of any one the polyamines or the salts or derivatives thereof in the test sample as compared to a reference is indicative of the non-infectious medical condition or a predisposition to develop such condition. The present invention is also directed to a kit-of-parts for diagnosing and/or monitoring in a subject a non-infectious medical condition or a predisposition to develop such condition, comprising means for detecting and/or analyzing one or more polyamines or one or more salts or derivatives thereof, as defined herein, as well as to the use of one or more polyamines or one or more salts or derivatives thereof, as defined herein, as a panel of molecular markers for diagnosing a non-infectious medical condition or a predisposition to develop such condition.
PCT/EP2011/062006 2010-07-13 2011-07-13 Methods and compositions for diagnosing medical conditions WO2012007531A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36380310P 2010-07-13 2010-07-13
US61/363,803 2010-07-13

Publications (2)

Publication Number Publication Date
WO2012007531A2 WO2012007531A2 (en) 2012-01-19
WO2012007531A3 true WO2012007531A3 (en) 2012-03-08

Family

ID=44512366

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/062006 WO2012007531A2 (en) 2010-07-13 2011-07-13 Methods and compositions for diagnosing medical conditions

Country Status (1)

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WO (1) WO2012007531A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104678003A (en) * 2013-11-29 2015-06-03 沈阳药科大学 Biomarker for evaluating liver cancer disease by using urine
JP6820545B2 (en) * 2016-10-27 2021-01-27 学校法人順天堂 How to determine the severity of Parkinson's disease
RU2766728C1 (en) * 2021-04-27 2022-03-15 Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью Method for determining predisposition to dysfunction of the autonomic nervous system in females associated with excessive contamination with hexane
WO2023039245A1 (en) * 2021-09-10 2023-03-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Biomarkers for nonalcoholic steatohepatitis and treatments thereof

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Publication number Priority date Publication date Assignee Title
US5948625A (en) * 1997-03-17 1999-09-07 Incyte Pharmaceuticals, Inc. Method of screening for ATP synthase Fo subunit
EP1729129A1 (en) * 2004-03-25 2006-12-06 Fuence Co. Ltd. Method of diagnosing apoplectic stroke/asymptomatic brain infarction using polyamine and acrolein contents, polyamine oxidase activity or protein content thereof as indication
US20090263400A1 (en) * 2006-02-06 2009-10-22 Tethys Bioscience, Inc. Osteoporosis associated markers and methods of use thereof

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US5349381A (en) 1992-02-28 1994-09-20 Sony Corporation Video camera with aperture correction having reduced power consumption
ITBZ20040048A1 (en) 2004-10-06 2005-01-06 Genprofiler METHOD FOR THE IDENTIFICATION OF NEOPLASTIC TRANSFORMATION, WITH PARTICULAR REFERENCE TO PROSTATIC CANCER
US20090176218A1 (en) 2005-10-21 2009-07-09 The General Hospital Corporation Method for the Diagnosis and Prognosis of Cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948625A (en) * 1997-03-17 1999-09-07 Incyte Pharmaceuticals, Inc. Method of screening for ATP synthase Fo subunit
EP1729129A1 (en) * 2004-03-25 2006-12-06 Fuence Co. Ltd. Method of diagnosing apoplectic stroke/asymptomatic brain infarction using polyamine and acrolein contents, polyamine oxidase activity or protein content thereof as indication
US20090263400A1 (en) * 2006-02-06 2009-10-22 Tethys Bioscience, Inc. Osteoporosis associated markers and methods of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Polyamine", INTERNET CITATION, 1 January 2011 (2011-01-01), pages 1 - 2, XP007919366, Retrieved from the Internet <URL:http://dictionary.reference.com/browse/polyamine?qsrc=2446> [retrieved on 20110907] *
DUAN BO ET AL: "Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 31, no. 6, 9 February 2011 (2011-02-09), pages 2101 - 2112, XP008142604, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.4351-10.2011 *
MOTYL T ET AL: "Polyamines and pyrimidines in blood plasma and urine of dogs bearing mammary tumours", JOURNAL OF VETERINARY MEDICINE SERIES A, vol. 41, no. 10, 1994, pages 766 - 769, XP008142680, ISSN: 0931-184X *
SAKATA KAORI ET AL: "Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 305, no. 1, 23 May 2003 (2003-05-23), pages 143 - 149, XP009121767, ISSN: 0006-291X, DOI: 10.1016/S0006-291X(03)00716-2 *
WIKIPEDIA: "Polyamine", INTERNET CITATION, 29 May 2010 (2010-05-29), pages 1 - 3, XP007919364, Retrieved from the Internet <URL:http://en.wikipedia.org/wiki/Polyamine> [retrieved on 20110907] *

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