WO2012005605A1 - A combination composition comprising ibuprofen and paracetamol - Google Patents

A combination composition comprising ibuprofen and paracetamol Download PDF

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Publication number
WO2012005605A1
WO2012005605A1 PCT/NZ2011/000117 NZ2011000117W WO2012005605A1 WO 2012005605 A1 WO2012005605 A1 WO 2012005605A1 NZ 2011000117 W NZ2011000117 W NZ 2011000117W WO 2012005605 A1 WO2012005605 A1 WO 2012005605A1
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WIPO (PCT)
Prior art keywords
approximately
ibuprofen
paracetamol
composition
combination
Prior art date
Application number
PCT/NZ2011/000117
Other languages
French (fr)
Inventor
Hartley Campbell Atkinson
Original Assignee
Aft Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aft Pharmaceuticals Limited filed Critical Aft Pharmaceuticals Limited
Priority to AU2011274652A priority Critical patent/AU2011274652B2/en
Priority to SG2012093183A priority patent/SG186388A1/en
Priority to NZ60400911A priority patent/NZ604009A/en
Publication of WO2012005605A1 publication Critical patent/WO2012005605A1/en
Priority to ZA2012/08210A priority patent/ZA201208210B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Definitions

  • This invention relates to a combination composition comprising paracetamol and ibuprofen.
  • a particularly preferred embodiment of the invention relates to a combination composition comprising these as active ingredients for use in relieving pain and/or inflammation.
  • Combinations of paracetamol and ibuprofen are known, for example as relatively low dose tablets having 150 mg ibuprofen and 500 mg.
  • a medication particularly one which can be administered intravenously in a hospital environment, which delivers higher doses of ibuprofen to provide pain relief in cases of severe or extreme pain. It is an object of one embodiment of the present invention to go at least some way towards facilitating this.
  • references in this specification to an adult mean a person weighing 50 kg or more.
  • references in this specification to a child mean a person weighing less than 50 kg.
  • compositions for providing relief for pain and/or inflammation having ibuprofen and paracetamol in combination for delivering to a human at each dose:
  • composition for delivering to the human (preferably an adult) at each dose approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol.
  • composition for delivering to the human (preferably an adult) at each dose approximately 600 mg ibuprofen and approximately 1 ,000 mg paracetamol.
  • composition for delivering to a child at each dose approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
  • composition for delivering to a child at each dose approximately 300 mg ibuprofen and approximately 500 mg paracetamol.
  • composition is for delivering the ibuprofen and paracetamol to the human (eg a child or adult) intravenously.
  • composition is in the form of a solution.
  • composition is in the form of a suspension.
  • a further aspect of the invention involves the use of ibuprofen and paracetamol in the manufacture of a medicament for treating pain and/or inflammation in a human, the medicament having:
  • the medicament has approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol. In this instance the medicament may be for treating an adult.
  • the medicament has approximately 600 mg ibuprofen and approximately 1 ,000 mg paracetamol.
  • the medicament may be for treating an adult.
  • the medicament is for treating a child and has approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
  • the medicament is for treating a child and has approximately 300 mg ibuprofen and approximately 500 mg paracetamol.
  • the medicament is for intravenous administration.
  • composition is in the form of a solution.
  • composition is in the form of a suspension.
  • a method of treating a human to relieve pain and/or inflammation comprising administering to the human: a) approximately 375 mg to approximately 425 mg ibuprofen,
  • approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol are administered to the human per dose.
  • the human is preferably an adult.
  • approximately 600 mg ibuprofen and approximately 1,000 mg paracetamol are administered to the human per dose.
  • the human is preferably an adult.
  • approximately 200 mg ibuprofen and approximately 500 mg paracetamol are administered to a child per dose.
  • approximately 300 mg ibuprofen and approximately 500 mg paracetamol are administered to a child per dose.
  • composition is administered to the human (eg an adult or child) intravenously.
  • composition is in the form of a solution.
  • composition is in the form of a suspension.
  • an intravenous solution for use in treating severe pain in human patients.
  • the solution is a combination medication comprising ibuprofen, paracetamol, purified water and suitable excipients as will be known to those with ordinary skills in the art of formulating intravenous medicines.
  • the excipients may be standard and may include one or more of suspending agents, viscosity regulating agents, buffering agents, wetting agents, preservatives, sweetening agents, flavouring agents and solvents.
  • Example 1 Example 2
  • Example 3 Example 4 mg/ 100ml vial mg/ 100ml vial mg/ 50ml vial mg/ 50ml vial
  • composition to composition 100 ml
  • All of the above infusion solutions are for delivery to a patient as a full dose, for example in each case the patient receives the complete vial contents as a 15 minute infusion every 6 hours.
  • Examples 1 , 2 and 5 are each an adult dose and Examples 3, 4 and 6 are each a child dose. In the case of very young or small children only part of the vial contents of Examples 3, 4 and 6 may be dosed, commensurate with instructions from the prescribing physician.
  • Paracetamol at 4,000 mg per 24 hour period taken in 4 doses of 1,000 mg every 6 hours, has long been considered sufficient for relieving low level pain but for many patients suffering significant pain, for example in some post-operative situations, it is not sufficient. However it is generally not advisable to dose paracetamol at more than 1 ,000 mg per dose or at more than 4,000 mg per 24 hour period, because to do so can lead to undesirable side effects.
  • ibuprofen It is known to treat severe pain with ibuprofen in doses of 800 mg every 8 hours. However, doses as high as 800 mg can lead to undesirable side effects, for example adverse cardio renal conditions, thrombotic risks and gastrointestinal bleeding. Reducing the amount of ibuprofen at each dosing event may reduce the risk of side affects but at the same time may provide substantially less pain relief.
  • a combination medicine comprising 600 mg or 400 mg ibuprofen, plus 1 ,000 mg paracetamol, for use every 6 hours, provides adequate pain relief for some patients that would otherwise take 800 mg ibuprofen every 8 hours.
  • ibuprofen and paracetamol are specifically referred to in this specification, suitable other pharmaceutically acceptable forms of these two actives (eg salts, etc) may also be used and are intended to be embraced in the claims by references to the actives per se, with the weight amounts adjusted accordingly.
  • suitable other pharmaceutically acceptable forms of these two actives eg salts, etc
  • sufficient quantity may be included to meet the desired amount of the compound per se (eg, 200 mg ibuprofen corresponds with 368 mg ibuprofen arginine, or 342 mg ibuprofen lysinate).
  • a reference to 200 mg ibuprofen may be construed as sufficient to embrace the therapeutically equivalent amount of ibuprofen arginine or ibuprofen lysinate.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A combination composition for providing relief for pain and/or inflammation, the composition having ibuprofen and paracetamol and being suitable for use in delivering to a human intravenously at each dose: a) approximately 375 mg to approximately 425 mg ibuprofen, in combination with approximately 975 mg to approximately 1,025 mg paracetamol; or b) approximately 175 mg to approximately 225 mg ibuprofen, in combination with approximately 475 mg to approximately 525 mg paracetamol.

Description

TITLE
A COMBINATION COMPOSITION COMPRISING IBUPROFEN AND PARACETAMOL
FIELD OF INVENTION
This invention relates to a combination composition comprising paracetamol and ibuprofen. A particularly preferred embodiment of the invention relates to a combination composition comprising these as active ingredients for use in relieving pain and/or inflammation.
BACKGROUND
Combinations of paracetamol and ibuprofen are known, for example as relatively low dose tablets having 150 mg ibuprofen and 500 mg. However there is a need for a medication, particularly one which can be administered intravenously in a hospital environment, which delivers higher doses of ibuprofen to provide pain relief in cases of severe or extreme pain. It is an object of one embodiment of the present invention to go at least some way towards facilitating this.
DEFINITIONS
References in this specification to an adult mean a person weighing 50 kg or more.
References in this specification to a child mean a person weighing less than 50 kg.
The term "comprising" and derivatives thereof, eg "comprises", if and when used herein in relation to a combination of features should not be taken as excluding the possibility that the combination may have further unspecified features.
SUMMARY OF INVENTION
According to one aspect of the invention there is provided a composition for providing relief for pain and/or inflammation, the composition having ibuprofen and paracetamol in combination for delivering to a human at each dose:
a) approximately 375 mg to approximately 425 mg ibuprofen,
b) approximately 575 mg to approximately 625 mg ibuprofen,
c) approximately 175 mg to approximately 225 mg ibuprofen, or
d) approximately 275 mg to approximately 325 mg ibuprofen, in the case of option a) or b) in combination with approximately 975 mg to approximately 1 ,025 mg paracetamol, or in the case of options c) or d) in combination with approximately 475 mg to approximately 525 mg paracetamol.
Optionally the composition is for delivering to the human (preferably an adult) at each dose approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol.
Optionally the composition is for delivering to the human (preferably an adult) at each dose approximately 600 mg ibuprofen and approximately 1 ,000 mg paracetamol.
Optionally the composition is for delivering to a child at each dose approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
Optionally the composition is for delivering to a child at each dose approximately 300 mg ibuprofen and approximately 500 mg paracetamol.
Optionally the composition is for delivering the ibuprofen and paracetamol to the human (eg a child or adult) intravenously.
Optionally the composition is in the form of a solution.
Optionally the composition is in the form of a suspension.
A further aspect of the invention involves the use of ibuprofen and paracetamol in the manufacture of a medicament for treating pain and/or inflammation in a human, the medicament having:
a) approximately 375 mg to approximately 425 mg ibuprofen,
b) approximately 575 mg to approximately 625 mg ibuprofen,
c) approximately 175 mg to approximately 225 mg ibuprofen, or
d) approximately 275 mg to approximately 325 mg ibuprofen,
in the case of option a) or b) in combination with approximately 975 mg to approximately 1 ,025 mg paracetamol, or in the case of options c) or d) in combination with approximately 475 mg to approximately 525 mg paracetamol. Optionally the medicament has approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol. In this instance the medicament may be for treating an adult.
Optionally the medicament has approximately 600 mg ibuprofen and approximately 1 ,000 mg paracetamol. In this instance the medicament may be for treating an adult.
Optionally the medicament is for treating a child and has approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
Optionally the medicament is for treating a child and has approximately 300 mg ibuprofen and approximately 500 mg paracetamol.
Optionally the medicament is for intravenous administration.
Optionally the composition is in the form of a solution.
Optionally the composition is in the form of a suspension.
According to a further aspect of the invention there is provided a method of treating a human to relieve pain and/or inflammation, comprising administering to the human: a) approximately 375 mg to approximately 425 mg ibuprofen,
b) approximately 575 mg to approximately 625 mg ibuprofen,
c) approximately 175 mg to approximately 225 mg ibuprofen, or
d) approximately 275 mg to approximately 325 mg ibuprofen,
in the case of option a) or b) in combination with approximately 975 mg to approximately 1 ,025 mg paracetamol, or in the case of options c) or d) in combination with approximately 475 mg to approximately 525 mg paracetamol.
Optionally approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol are administered to the human per dose. In this instance the human is preferably an adult. Optionally approximately 600 mg ibuprofen and approximately 1,000 mg paracetamol are administered to the human per dose. In this instance the human is preferably an adult.
Optionally approximately 200 mg ibuprofen and approximately 500 mg paracetamol are administered to a child per dose.
Optionally approximately 300 mg ibuprofen and approximately 500 mg paracetamol are administered to a child per dose.
Optionally the composition is administered to the human (eg an adult or child) intravenously.
Optionally the composition is in the form of a solution. Optionally the composition is in the form of a suspension. DETAILED DESCRIPTION
In a preferred embodiment of the invention an intravenous solution is provided for use in treating severe pain in human patients. The solution is a combination medication comprising ibuprofen, paracetamol, purified water and suitable excipients as will be known to those with ordinary skills in the art of formulating intravenous medicines.
The excipients may be standard and may include one or more of suspending agents, viscosity regulating agents, buffering agents, wetting agents, preservatives, sweetening agents, flavouring agents and solvents.
The following examples illustrate preferred embodiments of the invention in the form of intravenous infusion solutions although the invention should not be seen as limited to these. Ingredient Example 1 Example 2 Example 3 Example 4 mg/ 100ml vial mg/ 100ml vial mg/ 50ml vial mg/ 50ml vial
Ibuprofen 400 600 200 300
Paracetamol 1 ,000 1 ,000 500 500
For each of the above examples the two active ingredients are mixed with suitable amounts of the following excipients to give the vial volumes indicated in the above table:
• Cysteine hydrochloride monohydrate
• Disodium phosphate dehydrate
• Mannitol
• Hydrochloric acid
• Sodium hydroxide
• Purified water
Further examples of intravenous infusion solutions are provided below
Ingredient Example 5 Example 6
(adult dose) (child dose)
Ibuprofen arginine 737 mg 368 mg
(active ingredient) (corresponds to 400 mg (corresponds to 200 mg
ibuprofen) ibuprofen)
Paracetamol 1 ,000 mg 500 mg
(active ingredient)
Reduced glutathione 20 mg 20 mg
(antioxidant)
Sodium hydroxide or Sufficient to give a Sufficient to give a pH hydrochloric acid pH of 5-6 of 5-6
(pH modulator) Sodium citrate 10 mg 10 mg
(buffering agent)
Sodium chloride Sufficient to impart Sufficient to impart
(isotonicity agent) isotonicity isotonicity
Purified water Sufficient to bring Sufficient to bring the
the composition to composition to 100 ml
100 ml
All of the above infusion solutions are for delivery to a patient as a full dose, for example in each case the patient receives the complete vial contents as a 15 minute infusion every 6 hours. Examples 1 , 2 and 5 are each an adult dose and Examples 3, 4 and 6 are each a child dose. In the case of very young or small children only part of the vial contents of Examples 3, 4 and 6 may be dosed, commensurate with instructions from the prescribing physician.
Paracetamol at 4,000 mg per 24 hour period, taken in 4 doses of 1,000 mg every 6 hours, has long been considered sufficient for relieving low level pain but for many patients suffering significant pain, for example in some post-operative situations, it is not sufficient. However it is generally not advisable to dose paracetamol at more than 1 ,000 mg per dose or at more than 4,000 mg per 24 hour period, because to do so can lead to undesirable side effects.
It is known to treat severe pain with ibuprofen in doses of 800 mg every 8 hours. However, doses as high as 800 mg can lead to undesirable side effects, for example adverse cardio renal conditions, thrombotic risks and gastrointestinal bleeding. Reducing the amount of ibuprofen at each dosing event may reduce the risk of side affects but at the same time may provide substantially less pain relief.
Surprisingly, a combination medicine comprising 600 mg or 400 mg ibuprofen, plus 1 ,000 mg paracetamol, for use every 6 hours, provides adequate pain relief for some patients that would otherwise take 800 mg ibuprofen every 8 hours. The lower dose of ibuprofen, ie 600 mg or 400 mg, versus 800 mg, may reduce the risk of undesirable side affects but the effectiveness of the medication is for such patients not compromised due to the presence of the paracetamol. This is unexpected because one would not predict the presence of paracetamol at only 1 ,000 mg per dose to assist to any significant degree. The combination is counterintuitive because 800 mg ibuprofen for relief of severe pain is generally seen as an 8 hourly medicament, and 1 ,000 mg paracetamol is generally seen as a 6 hourly medicament for treating lower level pain. The normal dosage regimens for these active ingredients are out of step with one another, ie 8 hourly versus 6 hourly, and thus to the normally skilled artesian they would not, at the doses of the present invention, be seen as suitable for a combination medication.
Similar considerations apply in the case of 200 mg or 300 mg ibuprofen, in combination with 500 mg paracetamol, for treating children suffering from severe pain. In this regard, surprisingly, some children that would normally be given 400 mg ibuprofen for severe pain can be given, as an alternative, 200 mg or 300 mg ibuprofen, in combination with 500 mg paracetamol.
ALTERNATIVE CHEMICAL FORMS
While ibuprofen and paracetamol are specifically referred to in this specification, suitable other pharmaceutically acceptable forms of these two actives (eg salts, etc) may also be used and are intended to be embraced in the claims by references to the actives per se, with the weight amounts adjusted accordingly. For example, when a salt form is used, sufficient quantity may be included to meet the desired amount of the compound per se (eg, 200 mg ibuprofen corresponds with 368 mg ibuprofen arginine, or 342 mg ibuprofen lysinate). Thus, for example, a reference to 200 mg ibuprofen may be construed as sufficient to embrace the therapeutically equivalent amount of ibuprofen arginine or ibuprofen lysinate.
While some preferred forms of the invention have been described by way of example it should be appreciated that modifications and improvements can occur without departing from the scope of the appended claims.

Claims

1. A combination composition for providing relief for pain and/or inflammation, the composition having ibuprofen and paracetamol and being suitable for use in delivering to a human intravenously at each dose:
a) approximately 375 mg to approximately 425 mg ibuprofen, in combination with approximately 975 mg to approximately 1 ,025 mg paracetamol; or
b) approximately 175 mg to approximately 225 mg ibuprofen, in combination with approximately 475 mg to approximately 525 mg paracetamol.
2. A composition according to claim 1 , for delivering to the human at each dose approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol.
3. A composition according to claim 2, wherein the human is an adult.
4. A composition according to claim 1 , for delivering to a child at each dose approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
5. A composition according to any one of claims 1 to 4, in the form of a solution.
6. A composition according to any one of claims 1 to 4, in the form of a solid suitable for mixing with a fluid to provide a solution.
7. A composition according to claim 1 , for intravenous administration on a 12.5 mg paracetamol per kg body weight basis.
8. A composition according to claim 7, for administration every 6 hours.
9. The use of ibuprofen and paracetamol in the manufacture of a combination medicament for treating pain and/or inflammation in a human by intravenous administration, the medicament having: a) approximately 375 mg to approximately 425 mg ibuprofen, in combination with approximately 975 mg to approximately 1 ,025 mg paracetamol; or
b) approximately 175 mg to approximately 225 mg ibuprofen, in combination with 475 mg to 525 mg paracetamol.
10. A use according to claim 9, wherein the medicament has approximately 400 mg ibuprofen and approximately 1 ,000 mg paracetamol.
11. A use according to claim 10, wherein the medicament is for treating an adult.
12. A use according to claim 9, wherein the medicament is for treating a child and has approximately 200 mg ibuprofen and approximately 500 mg paracetamol.
13. A use according to any one of claims 9 to 12, wherein the composition is in the form of a solution.
14. A use according to any one of claims 9 to 12, wherein the composition is in the form of a solid suitable for mixing with a fluid to provide a solution.
15. A use according to claim 9, wherein the composition is for intravenous administration on a 12.5 mg paracetamol per kg body weight basis.
16. A use according to claim 15, wherein the composition is for administration every 6 hours.
PCT/NZ2011/000117 2010-07-07 2011-06-21 A combination composition comprising ibuprofen and paracetamol WO2012005605A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2011274652A AU2011274652B2 (en) 2010-07-07 2011-06-21 A combination composition comprising ibuprofen and paracetamol
SG2012093183A SG186388A1 (en) 2010-07-07 2011-06-21 A combination composition comprising ibuprofen and paracetamol
NZ60400911A NZ604009A (en) 2010-07-07 2011-06-21 A combination composition comprising ibuprofen and paracetamol
ZA2012/08210A ZA201208210B (en) 2010-07-07 2012-12-06 A combination composition comprising ibuprofen and paracetamal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ58666110 2010-07-07
NZ586661 2010-07-07

Publications (1)

Publication Number Publication Date
WO2012005605A1 true WO2012005605A1 (en) 2012-01-12

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AU (1) AU2011274652B2 (en)
MY (1) MY164112A (en)
NZ (1) NZ604009A (en)
SG (1) SG186388A1 (en)
WO (1) WO2012005605A1 (en)
ZA (1) ZA201208210B (en)

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WO2012060719A1 (en) * 2010-11-04 2012-05-10 Aft Pharmaceuticals Limited A combination composition
CN103565733A (en) * 2012-07-31 2014-02-12 南京帝易医药科技有限公司 Ibuprofen sodium chloride injection preparation with pH of 6.0-6.5, and preparation method thereof
US11197830B2 (en) 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen
WO2023281089A2 (en) 2021-07-08 2023-01-12 Krka, D.D., Novo Mesto Pharmaceutical composition comprising naproxen and paracetamol

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Cited By (9)

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Publication number Priority date Publication date Assignee Title
WO2012060719A1 (en) * 2010-11-04 2012-05-10 Aft Pharmaceuticals Limited A combination composition
AU2011324137B2 (en) * 2010-11-04 2015-05-07 Aft Pharmaceuticals Limited A combination composition
US11446266B2 (en) 2010-11-04 2022-09-20 Aft Pharmaceuticals Limited Combination composition
US11896567B2 (en) 2010-11-04 2024-02-13 Aft Pharmaceuticals Limited Combination composition
CN103565733A (en) * 2012-07-31 2014-02-12 南京帝易医药科技有限公司 Ibuprofen sodium chloride injection preparation with pH of 6.0-6.5, and preparation method thereof
US11197830B2 (en) 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen
US11534407B2 (en) 2019-02-27 2022-12-27 Aft Pharmaceuticals Limited Pharmaceutical compostion containing acetominophen and ibuprofen
US11872317B2 (en) 2019-02-27 2024-01-16 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetominophen and ibuprofen
WO2023281089A2 (en) 2021-07-08 2023-01-12 Krka, D.D., Novo Mesto Pharmaceutical composition comprising naproxen and paracetamol

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MY164112A (en) 2017-11-30
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