WO2012004758A1 - Suture thread - Google Patents

Suture thread Download PDF

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Publication number
WO2012004758A1
WO2012004758A1 PCT/IB2011/053016 IB2011053016W WO2012004758A1 WO 2012004758 A1 WO2012004758 A1 WO 2012004758A1 IB 2011053016 W IB2011053016 W IB 2011053016W WO 2012004758 A1 WO2012004758 A1 WO 2012004758A1
Authority
WO
WIPO (PCT)
Prior art keywords
thread
main body
stopper
correspondence
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2011/053016
Other languages
French (fr)
Inventor
Maurizio Longo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assut Europe SpA
Original Assignee
Assut Europe SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2013517664A priority Critical patent/JP5449621B2/en
Priority to CN201180033245.9A priority patent/CN103025251B/en
Priority to RU2013105012/14A priority patent/RU2559223C2/en
Priority to BR112013000513-0A priority patent/BR112013000513B1/en
Priority to CA2802020A priority patent/CA2802020C/en
Priority to EP11749914.5A priority patent/EP2590574B1/en
Priority to AU2011275357A priority patent/AU2011275357B2/en
Priority to MX2013000304A priority patent/MX2013000304A/en
Application filed by Assut Europe SpA filed Critical Assut Europe SpA
Priority to US13/807,922 priority patent/US8747438B2/en
Priority to ES11749914.5T priority patent/ES2444547T3/en
Priority to KR1020137003143A priority patent/KR101865978B1/en
Publication of WO2012004758A1 publication Critical patent/WO2012004758A1/en
Anticipated expiration legal-status Critical
Priority to US14/266,635 priority patent/US9345466B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B17/06119—Packages or dispensers for needles or sutures of cylindrical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0406—Pledgets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0417—T-fasteners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0464—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B2017/06052—Needle-suture combinations in which a suture is extending inside a hollow tubular needle, e.g. over the entire length of the needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A61B2017/06176—Sutures with protrusions, e.g. barbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A61B2017/0619—Sutures thermoplastic, e.g. for bonding, welding, fusing or cutting the suture by melting it

Definitions

  • the present invention refers to a thread, especially for use as a suture thread.
  • Figure 3 shows a perspective view of the suture thread of Figure 1 , in use during surgery.
  • Figures 4A, 4B and 4C show schematic front views illustrating three respective steps of a preferred method for manufacturing the suture thread of Figure 1.
  • a suture thread according to a first preferred embodiment of the invention is generally denoted by 1.
  • the spikes 4 can be applied on the main body 2 in a monolateral way, as in the depicted example, or in a plurilateral way. In both cases they can be manufactured in a monodirectional way, as in the depicted example, or in a pluridirectional way, i.e. have a tilt along a single direction or along plural divergent directions. Moreover, the spikes 4 can be applied on the main body 2 even along a helical path or a spiral-like path.
  • the thread 1 provides a stopper 3 having a section enlarged with respect to the main body 2 itself.
  • the stopper 3 has a diameter D of about 4 mm and a thickness S comprised in a range of about 1-2 mm.
  • Main body 2 and stopper 3 can be made both of a same material and of different materials, preferably of absorbable synthetic type.
  • the stopper 3 can be fixed to the main body 2 by heat-sealing.
  • a plurality of suture threads may be provided in various calibers, preferably comprised in the range USP 6/0 - 8, and in various lengths.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)

Abstract

A suture thread (1), comprising: - a thread-shaped main body (2) having spikes; and - a stopper cylinder (3) having a diameter enlarged with respect to the main body (2), which stopper cylinder (3) is arranged in correspondence of a longitudinal end (21) of the main body (2) to block said end in abutment against a tissue flap.

Description

SUTURE THREAD
DESCRIPTION
The present invention refers to a thread, especially for use as a suture thread.
The operation of surgical nature most frequently performed in operating room and outpatient clinic surgery is certainly that of suturing by thread. In spite of the frequency and the "historicity" of use of the suture threads, the in situ blocking modes of the ends thereof have not been optimized yet. In particular, in order to secure one end of the thread against a portion of biological tissue, the same thread is generally knotted on itself.
However, this blocking mode is intrinsically less than reliable as the knot, over time, tends to come undone; this entails that, for each suturing operation that proves necessary during surgery, the operator is forced to make a high number of knots in sequence. Therefore, the entire suturing operation carried out through the knotting technique requires a non-negligible time significantly affecting the total length of the intervention, with the associated consequences for the patient's wellbeing.
Therefore, the technical problem set and solved by the present invention is that of providing a thread - and in particular a suture thread - allowing to overcome the drawbacks mentioned above with reference to the known art.
Such a problem is solved by a thread according to claim 1.
Preferred features of the present invention are set forth in the dependent claims thereof.
The present invention provides some relevant advantages. The main advantage lies in the fact that the thread of the invention, by being equipped with a stopper included in correspondence of a longitudinal end of the thread itself, allows to reduce surgical times, eliminating the need to make plural knots, and concomitantly improving the reliability of the sutures, since the block is not subject to the drawback of coming undone. Moreover, by eliminating the need to knot the main body of the thread on itself, the invention allows a greater variety of choice for the rigidity level of the latter and for the materials of which it is made, thereby allowing to meet any type of suturing and surgery need.
Other advantages, features and operation steps of the present invention will be made apparent in the following detailed description of some embodiments thereof, given by way of example and not for limitative purposes. Reference will be made to the figures of the annexed drawings, wherein:
■ Figure 1 shows a perspective view of a first preferred embodiment of the suture thread according to the present invention;
■ Figure 1 A shows an enlarged view of a detail of the thread of Figure 1 ;
■ Figure 2 shows a perspective view of a second preferred embodiment of the suture thread according to the present invention;
■ Figure 3 shows a perspective view of the suture thread of Figure 1 , in use during surgery; and
■ Figures 4A, 4B and 4C show schematic front views illustrating three respective steps of a preferred method for manufacturing the suture thread of Figure 1.
Referring initially to Figures 1 and 1A, a suture thread according to a first preferred embodiment of the invention is generally denoted by 1.
The thread 1 comprises first of all an elongated main body 2 having just a thread-like shape. The main body 2 is preferably flexible and extends, in a straight and extended configuration, along a longitudinal axis A.
On the main body 2 there are preferably provided holding spikes 4, i.e. thread portions arranged obliquely with respect to the prevalent direction of development of the main body 2 and apt, by virtue of said tilt, to engage the tissue sutured by the thread itself so as to prevent the unthreading of the latter along a given pull direction. Also the length and the thickness of the spikes 4 can be selected depending on the selected cutting tilt.
The spikes 4 can be applied on the main body 2 in a monolateral way, as in the depicted example, or in a plurilateral way. In both cases they can be manufactured in a monodirectional way, as in the depicted example, or in a pluridirectional way, i.e. have a tilt along a single direction or along plural divergent directions. Moreover, the spikes 4 can be applied on the main body 2 even along a helical path or a spiral-like path.
In correspondence of a first longitudinal end 21 of the main body 2, the thread 1 provides a stopper 3 having a section enlarged with respect to the main body 2 itself.
Preferably, the stopper 3 has a substantially cylindrical shape, preferably with an axis of the cylinder aligned with the axis A of the main body 2.
Always according to a preferred embodiment, the stopper 3 has a diameter D of about 4 mm and a thickness S comprised in a range of about 1-2 mm.
During suturing, and as shown in Figure 3, the stopper 3, by virtue of its own section enlarged with respect to the main body 2, can block the corresponding longitudinal end 21 of the latter in abutment against a tissue flap.
Main body 2 and stopper 3 can be made both of a same material and of different materials, preferably of absorbable synthetic type.
In the present example, the stopper 3 and/or the main body 2 can be made of a material selected from a group comprising: glycolide polymer (PGA), copolymer of glycolide and lactide (PGLA), Poly(p-dioxanone) (PDO), copolymer of glycolide and epsilon-caprolactone (PGCL), and copolymer of Poly(l-lactide) and epsilon-caprolactone P(LA-CL).
The stopper 3 can be fixed to the main body 2 by heat-sealing.
In particular, a preferred embodiment schematically illustrated in Figures 4A, 4B and 4C envisages that the stopper 3 be made by melting of poly(p- dioxanone) polymer in suitable moulds 60 of cylindrical shape of the above- mentioned dimensions, preferably made in the form of openings shaped on a metal plate 61 resting on a board 62 heated to about 130°C.
The connection between stopper 3 and main body 2 is then obtained by the following steps:
- sealing of the "free" end 21 of the thread into the polymer paste still molten in the mould 60 (the correct positioning of the thread at the center of the cylindrical element can be guaranteed by a truing device positioned on the plate 61) - this step is schematically shown in Figure 4A; - removing the metal plate 61 from the heated board 62, in order to obtain the cooling of the plate itself - this step is schematically shown in Figure 4B; and
- separating the stopper from the metal plate - this step is schematically shown in Figure 4C.
Advantageously, the thread 1 is then prearranged, in correspondence of a second longitudinal end 22 of the main body 2 opposite to that associated to the stopper 3, with a suture needle 5 having a substantially straight or curved shape. Such a needle can be made of stainless steel (e.g. AISI 300 series or AISI 400 series).
According to a second preferred embodiment shown in Figure 2, a suture thread, denoted herein by 100, has a main body, denoted herein by 200, which comprises a pair of thread-shaped members 201 , 202, apt to define a generally ring-shaped or loop-like structure of the thread itself.
The thread 100 comprises a stopper 3 analogous to that already described above, and in this case as well it is prearranged with a suture needle, here substantially straight, denoted by 50.
It will be understood that a plurality of suture threads, each as described above with reference to Figures 1 and 2, may be provided in various calibers, preferably comprised in the range USP 6/0 - 8, and in various lengths.
It will also be understood that a plurality of suture threads, each as described above with reference to Figures 1 and 2, may be provided in the form of a reel. In particular, in that case threads will be arranged in a longitudinal sequence and removably connected in correspondence of respective ends.
It will be understood that although the invention has been described with specific reference to suture applications, it can advantageously be used for any type of surgical need in which the use of a thread to be blocked in situ be required.
Moreover, in a broader meaning the invention can find application also in a field different from the surgical one, for instance that of threads for sewing, especially in specialized fields like those of sewing or stitching technical fabrics, such as for use in fishing, motorcycling, etc.
The present invention has been hereto described with reference to preferred embodiments thereof. It is understood that other embodiments might exist, all falling within the concept of the same invention, as defined by the protective scope of the claims hereinafter.

Claims

1. A thread (1 ) for suture or other sewing or stitching applications, comprising:
- an elongated main body (2); and
- a stopper (3) having a section enlarged with respect to said main body (2), arranged in correspondence of a longitudinal end (21 ) of the latter to block said end in abutment against a tissue flap.
2. The thread (1) according to claim 1 , having, in correspondence of said main body (2), a plurality of holding spikes (4).
3. The thread (1 ) according to the preceding claim, wherein said holding spikes (4) are arranged on said main body (2) in a monolateral way, in a plurilateral way and/or along a helical path.
4. The thread (1) according to claim 2 or 3, wherein said holding spikes (4) are arranged on said main body (2) in a monodirectional or pluridirectional way.
5. The thread (100) according to any one of the preceding claims, having a substantially ring-shaped or loop-like configuration.
6. The thread (100) according to any one of the preceding claims, wherein said main body (200) comprises a pair of thread-shaped members (201 , 202).
7. The thread (1 ) according to any one of the preceding claims, wherein said stopper (3) has a substantially cylindrical shape, preferably with an axis (A) of the cylinder aligned with the direction of longitudinal development of said main body (2).
8. The thread (1) according to the preceding claim, wherein said stopper (3) has a diameter (D) of about 4 mm.
9. The thread (1 ) according to any one of the preceding claims, wherein said stopper (3) has a thickness (S) comprised in a range of about 1-2 mm.
10. The thread (1 ) according to any one of the preceding claims, wherein said stopper (3) is fixed to said main body (2) by heat-sealing.
11. The thread (1) according to any one of the preceding claims, wherein said stopper (3) and/or said main body (2) are made of a material selected from a group comprising: glycolide polymer (PGA), copolymer of glycolide and lactide (PGLA), Poly(p-dioxanone) (PDO), copolymer of glycolide and epsilon-caprolactone (PGCL), and copolymer of Poly(l-lactide) and epsilon- caprolactone P(LA-CL).
12. The thread (1) according to any one of the preceding claims, comprising a suture needle (5; 50) having a substantially straight or curved shape, arranged in correspondence of another longitudinal end (22) of said main body (2) opposite to that associated to said stopper (3).
13. A reel, comprising a plurality of threads (1), each according to any one of the preceding claims, which threads (1) are arranged in a longitudinal sequence and removably connected in correspondence of respective ends.
14. A method for manufacturing a thread (1) according to any one of the claims 1 to 12, comprising the steps of:
- providing the main body (2) of the thread;
- providing a mould having a shape corresponding to that of said stopper (3), preferably in the form of a seat (60) obtained in a plate (61);
- melting inside of said mould a selected material for manufacturing said stopper (3); and
- heat-sealing said main body (2) to said stopper (3) by inserting one end (21) of said main body (2) into said molten material and a subsequent cooling of the assembly.
PCT/IB2011/053016 2010-07-08 2011-07-07 Suture thread Ceased WO2012004758A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2011275357A AU2011275357B2 (en) 2010-07-08 2011-07-07 Suture thread
RU2013105012/14A RU2559223C2 (en) 2010-07-08 2011-07-07 Suture thread
BR112013000513-0A BR112013000513B1 (en) 2010-07-08 2011-07-07 SUTURE YARN, COIL AND METHOD FOR THE MANUFACTURE OF A YARN
CA2802020A CA2802020C (en) 2010-07-08 2011-07-07 Suture thread
EP11749914.5A EP2590574B1 (en) 2010-07-08 2011-07-07 Suture thread
MX2013000304A MX2013000304A (en) 2010-07-08 2011-07-07 Suture thread.
US13/807,922 US8747438B2 (en) 2010-07-08 2011-07-07 Suture thread
JP2013517664A JP5449621B2 (en) 2010-07-08 2011-07-07 Suture
CN201180033245.9A CN103025251B (en) 2010-07-08 2011-07-07 suture
ES11749914.5T ES2444547T3 (en) 2010-07-08 2011-07-07 Suture
KR1020137003143A KR101865978B1 (en) 2010-07-08 2011-07-07 Suture thread
US14/266,635 US9345466B2 (en) 2010-07-08 2014-04-30 Suture thread

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2010A000373 2010-07-08
ITRM2010A000373A IT1400838B1 (en) 2010-07-08 2010-07-08 SUTURE WIRE.

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/807,922 A-371-Of-International US8747438B2 (en) 2010-07-08 2011-07-07 Suture thread
US14/266,635 Continuation US9345466B2 (en) 2010-07-08 2014-04-30 Suture thread

Publications (1)

Publication Number Publication Date
WO2012004758A1 true WO2012004758A1 (en) 2012-01-12

Family

ID=43432073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/053016 Ceased WO2012004758A1 (en) 2010-07-08 2011-07-07 Suture thread

Country Status (13)

Country Link
US (2) US8747438B2 (en)
EP (1) EP2590574B1 (en)
JP (1) JP5449621B2 (en)
KR (1) KR101865978B1 (en)
CN (1) CN103025251B (en)
AU (1) AU2011275357B2 (en)
BR (1) BR112013000513B1 (en)
CA (1) CA2802020C (en)
ES (1) ES2444547T3 (en)
IT (1) IT1400838B1 (en)
MX (1) MX2013000304A (en)
RU (1) RU2559223C2 (en)
WO (1) WO2012004758A1 (en)

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WO2013181327A1 (en) * 2012-06-01 2013-12-05 Ethicon, Inc. Systems to treat upper pharyngeal airway of obstructive sleep apnea patients
US8905033B2 (en) 2011-09-28 2014-12-09 Ethicon, Inc. Modular tissue securement systems
US8915252B2 (en) 2008-12-01 2014-12-23 Ethicon, Inc. Implant systems and methods for treating obstructive sleep apnea
US8973582B2 (en) 2011-11-30 2015-03-10 Ethicon, Inc. Tongue suspension device and method
US9144511B2 (en) 2008-08-14 2015-09-29 Ethicon, Inc. Methods and devices for treatment of obstructive sleep apnea
US9161855B2 (en) 2011-10-24 2015-10-20 Ethicon, Inc. Tissue supporting device and method
US9326886B2 (en) 2009-10-29 2016-05-03 Ethicon, Inc. Fluid filled implants for treating obstructive sleep apnea
US9533446B2 (en) 2014-10-21 2017-01-03 Ethicon, Inc. Suture having a restraining element at an end and method and use thereof
USD780918S1 (en) 2015-09-04 2017-03-07 Ethicon, Inc. Welded end effector
EP3138507A1 (en) * 2015-09-04 2017-03-08 Ethicon, Inc. End effector for wound closure device
WO2017039677A1 (en) * 2015-09-04 2017-03-09 Ethicon, Inc. Improved end effector for wound closure device
US9877862B2 (en) 2009-10-29 2018-01-30 Ethicon, Inc. Tongue suspension system with hyoid-extender for treating obstructive sleep apnea
US9974683B2 (en) 2009-10-30 2018-05-22 Ethicon, Inc. Flexible implants having internal volume shifting capabilities for treating obstructive sleep apnea
US10213197B2 (en) 2014-10-21 2019-02-26 Ethicon Llc Suture having a restraining element at an end and method and use thereof
US10336001B2 (en) 2015-09-04 2019-07-02 Ethicon, Inc. End effector for wound closure device
US10470760B2 (en) 2011-12-08 2019-11-12 Ethicon, Inc. Modified tissue securement fibers

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CN101431947A (en) 2004-05-14 2009-05-13 奎尔医疗公司 Suturing method and apparatus
US20080255612A1 (en) * 2007-04-13 2008-10-16 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
EP2550978B1 (en) * 2007-09-27 2014-04-30 Ethicon, LLC A system for cutting a retainer in a suture
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
KR101883143B1 (en) 2010-05-04 2018-07-31 에티컨, 엘엘씨 Laser cutting system and methods for creating self-retaining sutures
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RU2013105012A (en) 2014-08-20
JP2013531533A (en) 2013-08-08

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