WO2011158248A3 - Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole - Google Patents

Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole Download PDF

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Publication number
WO2011158248A3
WO2011158248A3 PCT/IN2011/000254 IN2011000254W WO2011158248A3 WO 2011158248 A3 WO2011158248 A3 WO 2011158248A3 IN 2011000254 W IN2011000254 W IN 2011000254W WO 2011158248 A3 WO2011158248 A3 WO 2011158248A3
Authority
WO
WIPO (PCT)
Prior art keywords
posaconazole
preparation
polymorphic form
crystalline polymorphic
antifungal agent
Prior art date
Application number
PCT/IN2011/000254
Other languages
French (fr)
Other versions
WO2011158248A2 (en
Inventor
Milind Gharpure
Vivek Krishna
Srinivas Reddy Sanikommu
Ganesh Chaudhari
Jitendra Verdia
Mubeen Ahmed Khan
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2011158248A2 publication Critical patent/WO2011158248A2/en
Publication of WO2011158248A3 publication Critical patent/WO2011158248A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Disclosed are a process for preparation of an antifungal agent posaconazole and crystalline polymorphic form V of antifungal agent posaconazole.
PCT/IN2011/000254 2010-05-12 2011-04-15 Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole WO2011158248A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1520MU2010 2010-05-12
IN1520/MUM/2010 2010-05-12
IN2446/MUM/2010 2010-09-03
IN2446MU2010 2010-09-03
US40526610P 2010-10-21 2010-10-21
US61/405,266 2010-10-21

Publications (2)

Publication Number Publication Date
WO2011158248A2 WO2011158248A2 (en) 2011-12-22
WO2011158248A3 true WO2011158248A3 (en) 2012-03-08

Family

ID=45348684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000254 WO2011158248A2 (en) 2010-05-12 2011-04-15 Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole

Country Status (1)

Country Link
WO (1) WO2011158248A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105606736A (en) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 Method for separation determination of posaconazole intermediate Z1 and related substances of posaconazole intermediate Z1

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103852528B (en) * 2012-12-07 2016-02-03 重庆莱美药业股份有限公司 A kind of detection method of posaconazole
EP2789610A1 (en) * 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
ITMI20132114A1 (en) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa A CRYSTAL SHAPE OF POSACONAZOLO
ITMI20132117A1 (en) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa A CRYSTAL SHAPE OF POSACONAZOLO
ITMI20132118A1 (en) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa A CRYSTAL SHAPE OF POSACONAZOLO
ITMI20132115A1 (en) * 2013-12-18 2015-06-19 Djada Pharmaceutical Sa A CRYSTAL SHAPE OF POSACONAZOLO
CN104370894A (en) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 Preparation process of amorphous posaconazole
CN105622591B (en) * 2014-11-06 2018-09-21 博瑞生物医药（苏州）股份有限公司 A kind of preparation method of Novel triazole antifungal drug
ES2759801T3 (en) 2015-08-08 2020-05-12 Tiefenbacher Alfred E Gmbh & Co Kg Gastro-resistant formulation containing posaconazole
RU2750898C2 (en) * 2015-09-23 2021-07-05 Биокон Лимитед Crystal forms of the posaconazole intermediate compound and a method for the preparation of amorphous posaconazole
EP3210599A1 (en) 2016-02-26 2017-08-30 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
CN106749207A (en) * 2016-11-22 2017-05-31 上海博志研新药物技术有限公司 A kind of preparation method of posaconazole
CN108239077A (en) * 2016-12-26 2018-07-03 昆明积大制药股份有限公司 A kind of novel preparation method of posaconazole and its intermediate
EP4196096A1 (en) 2020-08-13 2023-06-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant high-strength formulation containing posaconazole
CN112903857A (en) * 2021-01-23 2021-06-04 河南泰丰生物科技有限公司 Method for effectively detecting isomer in posaconazole injection
WO2023012378A1 (en) 2021-11-25 2023-02-09 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN1850744A (en) * 2006-05-26 2006-10-25 中国科学院上海有机化学研究所 Method for synthesizing chiral methyl 1,3 functional group synthon
WO2009141837A2 (en) * 2008-05-21 2009-11-26 Ind-Swift Laboratories Limited Process for preparing posaconazole and intermediates thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN1850744A (en) * 2006-05-26 2006-10-25 中国科学院上海有机化学研究所 Method for synthesizing chiral methyl 1,3 functional group synthon
WO2009141837A2 (en) * 2008-05-21 2009-11-26 Ind-Swift Laboratories Limited Process for preparing posaconazole and intermediates thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105606736A (en) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 Method for separation determination of posaconazole intermediate Z1 and related substances of posaconazole intermediate Z1

Also Published As

Publication number Publication date
WO2011158248A2 (en) 2011-12-22

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