WO2011157209A1 - Medicine injector, control methods and driving assembly thereof - Google Patents

Abstract

A medicine injector includes an injector housing, a control system, an injector system and a motor driving system. Control methods of the medicine injector provide several control modes. A driving assembly for the medicine injector is also provided. The medicine injector has advantages of safety, good effect, and lower cost for insulin injection.

Description

 Drug sprayer and its tanning method and drive assembly

 This application is required to be submitted to the Chinese Patent Office on June 13, 2010, and the application number is 201010200726. 1. The Chinese patent application entitled "A pharmaceutical injector and its control method" was submitted to the Chinese Patent Office on May 26, 2011. Application No. 201120170801. 4. Chinese patent application entitled "Gearbox Separate Drive Module for Electronic Insulin Syringe", submitted to China Patent Office on May 26, 2011, application number 201120170589. 1. Named "Electronic Insulin Syringe" The priority of the Chinese Patent Application, the entire disclosure of which is incorporated herein by reference.

Technical field

 The present invention pertains to the field of medical supplies, and more particularly to a medicament injector and a method of controlling the same, and a drive assembly for the medicament injector.

Background technique

 [02] At present, diabetes has become the fourth biggest killer after heart, cerebrovascular disease and cancer.

 [03] The most effective treatment for diabetic patients is long-term injection of insulin. Most of the existing insulin syringes on the market are common syringes, including disposable syringes and reusable syringes.

 [04] Existing reusable insulin syringes, one is a purely mechanical injection pen, and the other is a syringe pump, but it is expensive and difficult to withstand by the general patient population.

 [05] The existing insulin pens such as Novo and pen, excellent pens, etc., have the following disadvantages: The dosage setting is troublesome, and the amount of the injection is adjusted before each use, due to the structure and size limitation of the injection pen itself. The tick marks are not only small but also tight. However, the patient is often old and debilitated, not only has poor eyesight, but also has difficulty completing such fine movements. Therefore, for the patient, the dose before each injection The setup has great difficulty, which has caused considerable obstacles to the life and treatment of the patient. Moreover, if the patient is not set properly, the excessive or insufficient injection may have serious consequences.

 [06] In addition, because the elderly are mostly forgetful, this conventional syringe has no special reminder function and is prone to the risk of missing or repeated injections.

 [07] For the market and society, an insulin syringe with appropriate price and ease of use is needed to help those elderly patients to be scientifically and correctly treated for long-term treatment, to achieve patient care, to maintain vitality and health, and to improve their lives. The comprehensive social purpose of quality.

Summary of the invention

[08] In view of the drawbacks and deficiencies of existing insulin syringes, one object of the present invention is A medicament injector is provided to achieve control of various working modes, and to facilitate the use of the patient.

 Another object of the present invention is to provide a control method for the above-described medicament injector, which comprises a plurality of control modes to facilitate different patients to achieve various conveniences based on different requirements and purposes.

 [10] A further object of the present invention is to provide a driving assembly for the above-mentioned medicine injector, which is driven by a DC motor, has a large reduction ratio range, and the motor can be started and stopped. The DC motor can be controlled by the photoelectric switch. And finally achieve the high-thrust, high-dose precision microinjection requirements of electronic insulin syringes.

 [11] The technical solution of the present invention is as follows:

 [12] A medicament injector comprising a syringe housing, characterized by: further comprising

 a control system, the control system being a microprocessor circuit board;

 In the injection system, the injection system includes an injection needle, an injection assembly and an injection advancement portion, and the injection assembly includes an injection needle fixing sleeve for fixing the injection needle, a drug cartridge and a piston, wherein the injection needle fixing sleeve and the drug cartridge are The integrated structure, the piston is disposed in the liquid cartridge, and the injection propulsion portion comprises a screw and an ejector tube, wherein the screw is disposed in the ejector tube, and a sliding threaded connection is arranged between the ejector tube and the ejector tube passes the sliding fitting The threaded connection moves linearly with the rotation of the screw, and the piston is connected with the ejector tube; the motor drive system includes an induction device and a stepping motor assembly, and the sensing device includes an induction disk and a photoelectric sensor, and the sensing disk edge is evenly distributed. There are a plurality of teeth, the sensing disc is fixedly connected with the output shaft of the stepping motor and rotates synchronously with the output shaft, and the sensing optical path of the photoelectric sensor corresponds to the position of the sensing disc tooth to monitor the rotation of the sensing disc;

 The above control system is electrically connected to the stepping motor and the photoelectric sensor, respectively.

 [13] Optionally, the injection propulsion portion further comprises an ejector tube protection sleeve, wherein the ejector tube is disposed in the ejector tube protection sleeve and is slidable relative to the ejector tube protection sleeve.

 [14] Optionally, the ejector tube and the ejector tube protection sleeve are slid by the T-shaped grooves and the protrusions which are fitted to each other.

 [15] Optionally, the medicament injector further comprises a display screen, a button, a buzzer and a USB interface, and is respectively connected to the control system.

[16] The method for controlling a medicament injector as described above, comprising: the following steps: (1) a microprocessor of the control system issues a pulse signal, and controls the stepping motor to rotate the corresponding angle and step according to the set direction. The angle, the stepping motor correspondingly drives the screw to rotate, and the ejector tube is in the sliding matching thread Under the action, the axial movement of the screw is performed linearly, and the piston is moved in the liquid cartridge to carry out the injection of the liquid medicine. The angular displacement of the stepping motor rotates linearly with the linear displacement of the piston, thereby realizing accurate medicine. Liquid injection; (2) The control system judges the working state of the stepping motor according to the monitoring signal of the photoelectric sensor to compare with the set working state, and judges whether the motor works normally, when the motor stops, blocks or rotates at different speeds due to abnormal conditions. (3) The control system is connected to the display, buttons, buzzer, and USB interface. The display is used for syringe status and injection data display. The button is used to set the working parameters of the syringe. The buzzer is used to remind The USB interface is used to connect and charge with computer equipment.

 [17] Further, the microprocessor is provided with a flash memory, and stores the control set in the following manner: (1) In the injection mode, the shortcut mode and the time sharing mode are included, and in the shortcut mode, the injection dose setting is completed. The stored injection dose parameter is directly stored in the flash memory, and the saved injection dose parameter is directly read from the flash memory as the current injection dose parameter before resetting the injection dose; in the time sharing mode, Corresponding injection dose parameters are set corresponding to different moments, and corresponding time reminders are set; (2) storing injection information, and storing the latest historical injection data in the flash memory in the FIFO mode, including the injection start time and the injection dose. And injection mode; (3) by button selection to display the information stored in the flash memory one by one, including historical injection data, or transfer the stored information to the host computer through the USB interface for display and review; (4) when two injections If the time interval is too short, the injection is prohibited, and the injection time interval threshold is set. When the time interval of the second injection is less than the threshold, the operation is prohibited; (5) The power saving mode is set to a time period, and when there is no operation within the time period, the low power consumption state is automatically entered, when the key operation is encountered. , automatically jumps out of the low power state and enters the normal working state.

 [18] Further, the following reminders are also included: (1) When the end of an injection, the buzzer reminds the end of the injection, and the set dose of the injection is displayed on the display screen, and the injection is ended; 2) The control system calculates the remaining dose in the liquid cartridge according to the stored injection information. When the remaining dose is less than the injection dose set this time, the alarm prompts to replace the liquid cartridge, and when the dose in the cartridge is exhausted, the control The system controls the stepping motor to automatically return to the initial position to replace the new cartridge; (3) monitor the battery voltage in real time, and the voltage information is transmitted to the control system through A/D conversion. When it is less than the set threshold, the alarm prompts charging. Or replace the battery, and prohibit the injection when the remaining battery power is lower than the threshold; (4) Remind the injection time, prompt the injection time through the display or buzzer.

[19] A drive assembly for a medicament injector, comprising: a reduction gear box, A photoelectric switch for detecting a rotation angle of the reduction gear set, and a DC motor and a corresponding power supply and control unit thereof, wherein an output shaft of the reduction gear box is extended as a screw of the medicament injector as described above.

 [20] Optionally, the reduction gear set includes three gear shafts arranged in parallel, which are a high speed gear shaft, an intermediate gear shaft and a low speed gear shaft, and each gear shaft is provided with a large gear and a pinion gear, and The large gear and the pinion rotate on the same gear shaft at the same angular speed, and the photoelectric switch is correspondingly disposed at the large gear of the high speed gear shaft.

 [21] Optionally, the DC motor is a hollow cup motor or a permanent magnet stepping motor.

 [22] Optionally, the driving component comprises a gear box body, a gear box cover, a reduction gear set installed in a cavity formed by the gear box body and the gear box cover, and a photoelectric switch for detecting a rotation angle of the gear of the reduction gear set, a DC motor, a DC stabilized power supply for supplying a DC motor, and a control unit for controlling the operation of the DC motor. The gear housing is provided with an output shaft screw for driving an electronic insulin injector, and the DC motor drives the shaft screw to rotate through the reduction gear set. . The operation of the DC motor is controlled by the control unit. The photoelectric switch detects the gear rotation angle of the reduction gear set in real time and feeds the data back to the control unit, so that the control unit can accurately control the operation of the DC motor. The DC motor drives the shaft screw to rotate through the reduction gear set. Achieve high thrust, high precision output.

 [23] The reduction gear set includes three gear shafts arranged in parallel, which are a high speed gear shaft, an intermediate gear shaft and a low speed gear shaft, and each gear shaft is provided with a large gear and a pinion gear, and the same gear shaft The upper large gear and the pinion rotate at the same angular speed, the pinion of the high speed gear shaft meshes with the large gear of the intermediate gear shaft, the pinion gear of the intermediate gear shaft meshes with the large gear of the low speed gear shaft, and the photoelectric switch is arranged at the high speed gear shaft The big gears. The photoelectric switch directly detects the rotation angle of the large gear of the high speed gear shaft, and feeds the data back to the control unit in real time.

 [24] In order to make the structure compact, the large gears and pinions on the same gear shaft are integrated, and the integrated structure makes the large gear and the pinion rotate synchronously, and the work is more reliable.

 [25] The high speed gear shaft, the intermediate gear shaft and the low speed gear shaft are integrally formed with the gear box body, and the gear box cover is provided with an axis corresponding to the high speed gear shaft, the intermediate gear shaft and the low speed gear shaft. hole. Although the integrated structure of the gear shaft and the gear case is difficult to manufacture, the entire device is assembled.

 [26] The gear box and the gear box cover are correspondingly provided with shaft holes for mounting a high speed gear shaft, an intermediate gear shaft and a low speed gear shaft.

[27] The DC motor is a hollow cup motor, and the gear box has a fixed installation space The motor mounting hole of the core cup motor is provided with a reinforcing rib on the periphery of the motor mounting hole, and the hollow cup motor has an output shaft, and the output shaft is provided with a gear meshing with the large gear of the high speed shaft.

 [28] One end of the shaft screw is provided with a toothed disc, and the shaft screw is mounted on the gear box through a toothed disc, and the toothed disc has a gear that meshes with a pinion of the low speed gear shaft and a mounting and fixing shaft A ring sleeve of the screw, the ring sleeve is provided with a toothed seat, one end of the toothed disc is mounted on the gear box body through a toothed seat, and the other end of the toothed disc is mounted on the gear box cover through a bearing.

 [29] The gear box of the gear box body is provided with a positioning rib for connecting the electronic insulin syringe at the box body of the shaft screw.

 [30] Optionally, the driving component comprises a permanent magnet stepping motor, a gear reduction box, a shaft screw and a control unit, wherein the gear reduction box has a reduction gear set, and the reduction gear set of the gear reduction box The input end is connected with the permanent magnet type stepping motor, and the output end of the reduction gear set is connected with the output shaft screw, and the control unit is connected with the permanent magnet type stepping motor. 7 The magnetic stepping motor drives the shaft screw to rotate through the gear reducer to achieve high torque output.

 [31] The permanent magnet type stepping motor comprises a casing assembly, a cover plate assembly integrally formed with the casing assembly, and a stator assembly and a rotor assembly disposed in the cavity formed by the casing assembly and the cover assembly. The two ends of the rotor assembly are respectively rotatably connected to the casing assembly and the cover assembly through a bearing support. One end of the rotor assembly protrudes from the cover assembly and is provided with an input gear coupled to the reduction gear set. The other end of the rotor assembly extends. The photoelectric module is provided with a photoelectric sensing disk and a photoelectric switch for sensing the rotation angle of the photoelectric sensing disk, and the photoelectric switch is electrically connected to the control unit. The photoelectric sensing disk is disposed on the rotor assembly of the permanent magnet type stepping motor, and the photoelectric sensing disk rotates synchronously following the rotor assembly, and the photoelectric switch detects the rotation angle of the photoelectric sensing disk in real time and feeds the data back to the control unit.

 [32] The gear reduction gearbox has a casing and a cover plate integrated with the casing, and the reduction gear set includes two high-speed gear shafts and a low-speed gear shaft arranged in parallel, and the high-speed gear shaft and the low-speed gear shaft are all set. There are large gears and pinion gears, and the large gears and pinions on the same gear shaft rotate at the same angular speed, and the pinion gears on the high speed gear shaft mesh with the large gears on the low speed gear shaft. Due to the slow speed of the permanent magnet stepping motor, the two-stage reduction gear set is used to make the whole machine smaller.

[33] The end face of the box has a mounting hole, and the input gear of the permanent magnet type stepping motor is meshed with the large gear on the high speed gear shaft through the mounting hole, and the cover plate is provided with a mounting screw Bearing hole, interference bearing in the bearing hole, the interference of the shaft screw is installed in the bore of the rolling bearing The output shaft screw extends into the cover plate and is fitted with an output gear that meshes with a pinion gear on the low speed gear shaft.

 [34] In order to make the shaft screw work more reliable and reduce the interference of radial forces, the rolling bearing is a double row rolling axis 7| or two parallel rolling axes 7

 [35] The technical effects of the present invention are:

 [36] The invention sends a pulse signal to the stepping motor by the control part, and then pushes the piston to move in the liquid cartridge through the screw and the ejector tube, and the angular displacement of the rotation of the stepping motor is thereby converted into a linear displacement of the piston, and the invention It is based on this linear relationship to achieve precise control of the injection dose of the drug (such as insulin), less transmission links, high accuracy, error 0.1U.

 [37] Existing insulin syringes are all prepared after the patient has set the injection volume. The syringe is injected. During the injection, there is no clear indication that the syringe is working properly. Due to the particularity of the injection behavior, whether the injection is correctly completed is not easy to detect, especially In the case that the drug bottle is opaque, the patient can judge whether the injection is successful only by his own feelings. For example, if the syringe has no sensor feedback device, the condition is increased, the patient does not know why, and the patient has a life risk.

 [38] In particular, in the present invention, a photoelectric sensing device is provided in the syringe, and the stepping motor operation information is fed back by the photoelectric sensing device. If the signal detected by the photoelectric sensor corresponds to the pulse signal sent by the control system to the stepping motor, the motor operates normally; if the signal detected by the photoelectric sensor does not match the pulse signal sent by the control system to the stepping motor, the motor runs abnormally. If the signal is not detected, it means that the motor stops. According to the setting of the control system, the motor is in abnormal working condition, then a warning is given to remind the patient that the syringe is not working properly, prompting to check the medication and avoiding hidden dangers.

 [39] The screw and the stepping motor of the invention are directly connected by a transmission component such as a coupling, and the unnecessary transmission link can be reduced. The screw and the ejector tube are threaded and slidable, and the thread angle can be adjusted to adjust the screw to move the motor shaft in a circular motion. It is transformed into the axial linear motion of the ejector tube. The ejector pipe thread material is made of wear-resistant materials such as polytetrafluoroethylene or polyacetal. During the movement, the wear rate is very small, so the service life is long and the wear failure rate is very low.

 [40] At the same time, the ejector tube of the present invention is further provided with an ejector tube sheath, and adopts a T-shaped groove and a slider to fit and slide, thereby ensuring smooth movement of the ejector tube along the ejector tube sheath and preventing The ejector tube rotates with the screw at the same time, which ensures the normal implementation of the injection action.

[41] The invention is intelligent in the control system, the invention is via a USB interface and internal The function of Flash can store and memorize the patient's injection information, which is convenient for users to inquire and use. It is also convenient for doctors to track and analyze. The control of the built-in program also greatly considers the convenience and safety of the patient.

 [42] Shortcut mode can directly replace the existing mechanical syringe, and can also store and recall historical injection dose values, operate clear cartridges for patient operation; Time-sharing mode also reflects intelligent features, rejects incorrect settings And operation, once the injection parameters are set, the injection conditions will be intelligently judged by themselves, and the human-computer interaction mode such as the display prompt, voice alarm, etc., avoids the unpredictable wrong operation caused by the patient's memory or poor eyesight, and avoids the injection. The occurrence of the accident greatly guarantees the safety of the injection.

 [43] The driving assembly of the syringe provided by the invention has a simple structure, is easy to manufacture, is driven by a DC motor, has a large reduction ratio range, and the motor can be controlled to start and stop; the rotation angle of the gear is detected by the photoelectric switch and the DC motor is controlled by the control unit. The operation makes the rotation angle of the reduction gear set accurately controlled, and finally realizes the micro-injection requirement of the high-thrust and high-dose precision of the electronic insulin syringe; the driving component and the electronic insulin injector are assembled reliably and are convenient to operate.

 [44] The driving component of the syringe provided by the invention adopts a permanent magnet type stepping motor to drive the gear reduction gear box, has a large transmission ratio, realizes low rotation speed and high torque output, and has high reliability, and detects the rotation angle of the photoelectric induction disk through the photoelectric switch and passes The control unit controls the permanent magnet stepping motor to realize the high-thrust and high-dose precision micro-injection requirements of the electronic insulin syringe; the driving component and the electronic insulin injector are assembled reliably and are convenient to operate.

DRAWINGS

 1 is a schematic structural view of a syringe according to an embodiment of the present invention.

 Fig. 2 is a partially enlarged schematic view showing a motor driving portion of a syringe according to an embodiment of the present invention.

 Fig. 3 is a partially enlarged schematic view showing the injection advancement portion of the syringe of the embodiment of the present invention.

 4 is a partially enlarged schematic view showing an injection portion of a syringe according to an embodiment of the present invention.

 Fig. 5 is a connection diagram of a driving portion of a syringe motor and an injection propelling portion according to an embodiment of the present invention.

Figure 6 is a cross-sectional view of an injection advancement portion of an embodiment of the present invention. Figure 7 is a block diagram of a power supply section and a control section of an embodiment of the present invention.

 8 is a flow chart showing the operation of the syringe of the embodiment of the present invention.

 Figure 9 is a cross-sectional view showing an embodiment of a driving assembly of a medicament injector of an embodiment of the present invention.

 Figure 10 is a perspective view of the drive assembly of the medicament injector of Figure 9.

 Figure 11 is a perspective view of another perspective view of the drive assembly of the medicament injector of Figure 9.

 Figure 12 is a cross-sectional view showing an embodiment of a driving assembly of a medicament injector of an embodiment of the present invention.

 [57] Figure 13 is a schematic diagram of gear transmission in a gear reduction box.

 [58] FIG. 14 is a schematic exploded view of the reduction gear set of the gear reduction case.

detailed description

 [59] The present invention will be further described below in conjunction with the accompanying drawings.

 [60] As shown in Fig. 1, the medicament injector includes a motor driving portion, an injection propulsion portion, an injection portion, a control portion and a power supply portion 13, and Figures 2, 3, and 4 are partial enlarged views of the respective portions, wherein

 [61] The control part is a microprocessor;

 [62] The motor driving part comprises: a stepping motor 22, the control part sends a pulse signal, and the magnetic steel rotor of the stepping motor 22 is driven to rotate by the chip decoding, the motor shaft 21 rotates synchronously with the magnetic steel rotor, and the induction is fixed on the motor shaft 21. The disk 23 is provided with a drum-shaped hole in the center of the sensing disk 23, and is closely fitted with the drum-shaped portion at the rear end of the motor shaft 21, so that the sensing disk 23 rotates synchronously with the motor shaft 21. The cross section of the sensing disk 23 is a gear shape, and the photoelectric sensor 24 is disposed at the edge of the sensing disc 23, and the sensing optical path corresponds to the tooth position of the sensing disc. Since the sensing disc 23 rotates synchronously with the stepping motor, when the motor rotates, the teeth of the sensing disc 23 intermittently block the sensing optical path, correspondingly, The photosensor 24 accordingly monitors the rotation of the sensing disc 23, and the photosensor 24 is connected to the control system.

 [63] The injection advancement portion includes: a screw 15 and an ejector tube 16, and the outer wall of the screw 15 and the inner wall of the ejector tube 16 are provided with matching threads, and the ejector tube 16 and the screw 15 are relatively axially moved by the thread, and the rotation of the screw Converting to the linear motion of the ejector tube, adjusting the thread angle can adjust the speed of the linear movement of the ejector tube relative to the screw.

[64] The injection part comprises: an injection assembly 5, an injection needle 3, the injection assembly 5 includes a piston 7, a liquid cartridge and an injection needle fixing sleeve 4, and the piston 7 is disposed in the liquid cartridge, and the ejection tube 16 connected, note The needle fixing sleeve 4 is integrally connected with the liquid medicine cartridge, and the injection needle 3 is fixed on the liquid medicine cartridge through the injection needle fixing sleeve 4, and communicates with the medicine liquid cylinder, and the injection liquid assembly 5 can select a commercially available product, and the injection needle 3 Use a single-use injection needle.

 [65] As shown in FIG. 5, the motor shaft 21 of the motor driving portion is connected to the screw 15 through the coupling 20, the screw 15 rotates synchronously with the motor shaft 21, and the screw 15 is converted into the ejector tube 16 along the motor with the synchronous rotation of the motor shaft 21. In the axial linear motion, the piston 7 is located in the liquid cartridge of the injection liquid assembly 5, and moves in the liquid cartridge with the movement of the ejector tube 16. The length of the ejector tube 16 is not less than the movement of the piston 7 in the liquid cartridge. Length of the trip. The coupling 20 is a soft connecting joint connecting the motor shaft 21 and the screw 15, and the inner cross section is a drum-shaped hole, which cooperates with the screw 15 and the drum-shaped outer cross section of the front end of the motor shaft 21.

 [66] The injection propulsion portion is provided with an ejector tube protection sleeve 17, and the ejector tube 16 slides within the ejector tube protection sleeve 17, and an ejector disc 10 is disposed between the ejector tube 16 and the piston 7 for ejector tube The movement of 16 smoothly pushes the piston 7 to move.

 [67] As shown in Fig. 6, the ejector tube sleeve 17 is provided with a T-shaped groove on the inner side thereof, and the outer side of the ejector tube 16 is provided with a protrusion corresponding to the T-shaped groove, and the protrusion slides in the T-shaped groove. The ejector tube sleeve 17 combined with the T-slot and the bumps allows the movement of the ejector tube 16 to be smoother and ensures accurate operation of the syringe.

 [68] As a preferred embodiment of the present invention, the motor driving portion, the injection propelling portion, the injection portion, the control portion and the power supply portion are all disposed in the syringe housing, the syringe housing is a pen type, the motor driving portion, and the injection is advanced. The part and the injection part are arranged on the same axis, the motor driving part is located at the tail end of the pen type syringe housing, the injection part is located at the tip end of the pen, the injection needle of the injection part protrudes out of the syringe casing, and the cap 1 is correspondingly arranged, and the sealed needle is arranged The control portion is disposed at the end of the pen, and the power supply portion 13 is disposed in the gap between the injection advancement portion and the syringe housing. The reasonable layout allows the syringe of the present invention to have a compact size and is convenient to carry.

[69] The injection part structure is specifically: one end of the medicine liquid cylinder connecting the injection needle 3 protrudes out of the syringe casing, and the protruding part is provided with a liquid chemical cartridge sheath 6 , and the cap 1 is sealed with the liquid chemical cartridge sheath 6 The injection needle, the corresponding injection needle in the cap 1 is provided with an injection needle sheath 2. Such a design allows the syringe of the present invention to be adapted to different lengths of the injection assembly 5, when different injection sections are required, mainly in the case where the volume of the injection assembly 5 is different, the syringe housing, the motor is driven In part, the injection propulsion portion, the control portion and the power supply portion 13 can be mass-produced, as long as the liquid cartridge corresponding to the injection liquid assembly is correspondingly configured with a liquid cartridge sheath of different specifications. [70] The drug injector is provided with a display 18, a button 9, a buzzer and a USB interface 25. The display 18, the button 9, the buzzer and the USB interface 25 are respectively connected to the control portion, and likewise, the internal structure of the entire syringe is laid out. Suitably, the display 18 and button 9 utilize a gap between the injection advancement portion and the syringe housing, disposed on the opposite side of the power supply portion, and the USB interface 25 is disposed adjacent to the control portion.

 [71] The display 18 uses a dot-matrix LCD display, and the button 9 uses a membrane button switch. By using the LCD display in conjunction with the button, the menu display is realized, the layer label of each level menu is recorded, and then the button is used. Turn to the layer you need to achieve a menu-like display.

 [72] The LCD status screen display includes:

 [73] (1) The real-time power of the battery;

 [74] (2) the remaining dose of the insulin cartridge;

 [75] (3) Dynamic display of current injection dose;

 [76] (4) Current mode status;

 [77] (5) The number of injections;

 [78] (6) Date and time.

 [79] The size of the selected LCD screen is 128 x 32, with the upper half as the status display and the lower half as the menu bar. This information can be displayed in real time on the LCD screen by monitoring the battery capacity and the remaining dose of the insulin cartridge. The current cycle and time can be displayed on the LCD screen by reading the real-time clock inside the microcontroller. The injection is dynamically displayed on the LCD screen in real time while the injection is in progress, telling the user that the injection is taking place at this time. Each time an injection is completed, information such as injection time and dose is stored in Flash, and these historical information can be viewed through the "Review" item in the menu.

 [80] The settings of button 9 include: real time clock, injection dose, number of injections and each injection time, menu total time, dose and review three options, in which there is a secondary menu under the dose option, secondary menu The content is shortcut mode and time-sharing mode. There are four buttons that match the menu display, namely "Exit (ESC)", "Confirm (ACT)", "Up" (Up), "DOWN" (DOWN). ", through the cooperation of these four buttons and the corresponding prompts on the LCD screen, you can set the system real-time clock, the injection dose (fast mode and the dose corresponding to the time-sharing mode of up to five time points), through the menu " Review the "Options to view information about previous injections.

[81] The injector of the invention is controlled by a control system, and the block diagram of each electronic control module is shown in FIG. 7. The electronic control part involved in the whole syringe is mainly composed of a microprocessor MCU, a button module, and a dot matrix LCD. The display, the motor drive unit, the photoelectric switch monitoring unit, the buzzer alarm unit, the USB interface unit, the power monitoring unit, the storage unit, the real-time clock RTC unit, the rechargeable lithium battery, and the power module.

 [82] The microprocessor MCU is the core of the system. It consists of a low-power high-performance processor MSP430F5437, which is used to accurately set the insulin injection dose, store and display the injection information, and drive the stepper motor to complete the syringe. Accurate drug push, abnormal situation alarm processing; button module and dot matrix LCD constitute the human-computer interaction part of the whole system, man-machine interaction unit completes the setting of real-time clock, insulin injection mode and injection dose setting, dot matrix LCD adopts Menud operation mode, display of syringe related information, various prompts and alarm information, etc. The motor drive unit is mainly composed of motor drive chip A3901, which is used to provide sufficient drive current to drive the stepper motor to rotate at the required speed. The real-time clock RTC is the MCU internal unit, which provides a time reference for the whole system operation; the storage unit is the MCU internal Flash, which is used to save some setting parameters and injection information; the buzzer alarm circuit is mainly used to make the sound prompt of the injection end event. And abnormal situation The photoelectric switch monitoring unit is mainly used for feedback monitoring of the rotating state of the motor. When abnormal conditions such as stalling and stalling occur, the MCU is notified to the abnormal condition in time; the power monitoring unit collects the lithium battery in real time by the A/D channel of the MCU. Voltage, when the voltage is lower than the set threshold, perform a low battery alarm; the USB interface unit is used for data transmission between the insulin injector and the upper computer, and transmits the historical injection information saved in the insulin syringe to the upper computer, and also The lithium battery can be charged by the USB interface; the rechargeable lithium battery provides power for the entire system, and the output voltage of the lithium battery is regulated to 3.3 volts by the power module TPS63031 to provide a stable operating voltage for each part of the system.

 [83] The invention can be powered by a single-cell lithium battery, and the output voltage of the lithium battery is converted into a DC voltage of 3.3V through the DC/DC module TPS63031, and is given to a unit such as a microprocessor, an LCD, a stepper motor driver, and a stepping motor. powered by. Using the universal USB interface, the battery charging management chip BQ24072 is used for control and management, and the lithium battery can be charged. The controller MSP430F5437 monitors the entire charging process. The LCD screen dynamically displays the charging status and real-time power of the lithium battery. After charging is completed. The LCD screen gives a text prompt for the end of charging.

 [84] FIG. 8 is a flow chart showing the operation of the syringe of the present invention, and the method for controlling the medicament injector includes:

[85] 1), the microprocessor of the control section issues a pulse signal, the microprocessor used in the present invention For the company's MSP430F5437, the stepper motor driver is used to drive the stepper motor to rotate the corresponding angle and step angle in the set direction. The screw connected to the stepping motor rotates accordingly, and the ejector tube matches the thread on the inner wall. Under the action, the axial displacement relative to the screw pushes the piston to move in the liquid cartridge, and then pushes the liquid in the liquid cartridge, and the angular displacement of the stepping motor is converted into a linear displacement of the piston. Controlling the injected dose of insulin;

 [86] 2), the sensing disk set on the stepping motor and the corresponding photoelectric sensor monitor the rotation of the motor. Since the sensing disk rotates synchronously with the motor, the control part determines the rotation state of the motor according to the monitoring signal of the photoelectric sensor, according to The currently set motor working state and the monitoring result of the photoelectric sensor determine whether the motor is working normally. When the motor stops or stops due to abnormal conditions, an alarm is issued; the cross section of the sensing disc is a gear shape, and the sensing optical path of the photoelectric sensor Corresponding to the position of the tooth, when the photoelectric sensor is working, there is always a continuous optical signal emitted through the tooth shape of the sensing disc. If the signal is uninterrupted, it means that the sensing disc is not rotating, that is, the motor shaft is not running, and vice versa, the photoelectric sensor Signal intermittent feedback, indicating that the induction disc is rotating, that is, the motor shaft and the screw are rotating, and the screw drives the ejector tube to move forward in the ejector tube sheath, and pushes the piston in the liquid medicine cylinder to squeeze the liquid medicine into the human body through the injection needle. Complete the injection process. If the motor stops during the injection process, the photoelectric sensor does not sense the rotation of the induction disk. According to the set program, the alarm prompts that the injection action is not completed normally. If the syringe shows a uniform rotation of the screw during the injection operation, it indicates that the motor shaft and the induction disc are rotating at a uniform speed, and the photoelectric sensor can sense a uniform intermittent signal, and feed back to the system chip, and the chip determines the injection according to the set program. The action is normal.

 [87] 3), the control part is connected to the man-machine interface, including display screen, button, buzzer and USB interface, the display is used for injector status and injection data display, the button is used to set the operation of the syringe, and the buzzer is used for Remind that the USB interface is used to connect and charge with computer equipment.

 [88] The microprocessor of the control part is equipped with a flash memory, and can intelligently determine the injection conditions, and performs the following operations:

 [89] 1 ), injection mode setting shortcut mode or time sharing mode:

 [90] In the shortcut mode, each time the injection dose is set, the parameters are stored in the flash memory, and if the new injection dose is not reset before each injection, the last save is directly read from the flash memory. Injection dose parameter, as the injection dose of the current injection;

[91] In time-sharing mode, set different injection dose values for different moments and set the alarm time reminder; Quick mode completely replaces the function of the existing pure mechanical insulin syringe, and the dose can be set. Injection, convenient use; Time-sharing mode sets different injection doses of up to five time points in a single day according to the patient's living habits, to meet the needs of different doses of insulin in different feeding states;

 [92] Especially in time-sharing mode, intelligently judges the validity of the set value, the wrong setting, such as the time interval between two injections is decisive, the time of the alarm far exceeds the effective action section of the injection time, etc., will be prohibited. It will not be saved to the flash memory. After the effective setting is completed, the corresponding dose is automatically selected at the time of injection, and the injection is prohibited when the effective section of the injection time is not reached, and the continuous injection within the same time period is prohibited;

 [93] 2), store injection information, use FIFO mode to store information, save the last 20 historical injection information in the storage area, including injection start time, injection dose and injection mode;

 [94] 3), browsing of historical injection data, the information stored in the flash memory is directly displayed on the display screen by button selection, or the stored information is transmitted to the upper computer through the USB interface, in the software on the upper computer Browse and review;

 [95] 4) Considering the efficacy and safety issues, the short interval between injections will have an adverse effect on the body. Therefore, if the interval between injections is too short, the injection is prohibited, and the injection interval threshold is set according to the storage. The last injection information, this injection time interval is less than the threshold to prohibit this injection;

 [96] 5) Set the power saving mode. If there is no operation after the set time, the injector enters the low power state to save power. The control part in the low power state encounters the key interruption. Jump out of the low power state and return to normal working mode.

 [97] The syringe has the following reminders:

 [98] 1), detecting the rotation of the motor during the injection process, once there is a stop, stall, abnormal rotation, the motor stops rotating, and a buzzer alarm is issued;

 [99] 2) When the injection is finished, the control part controls the buzzer to prompt the user to end the injection according to the monitoring signal of the photoelectric sensor, and displays the set dose of the injection on the display screen, and displays the injection. End;

 [100] 3), the control part calculates the remaining dose of the liquid medicine cartridge according to the stored injection information. When the remaining dose in the liquid medicine cylinder is less than the injection dose set this time, the buzzer sounds an alarm to remind the user to change the medicine. After the liquid medicine cartridge is completely injected, the control part controls the motor to automatically return to the initial position, and prepares to use the new liquid medicine cartridge for injection;

[101] 4), real-time monitoring of the battery voltage, voltage information is transmitted to the control part through A/D conversion, When it is less than the set threshold, an alarm is issued to remind the user to charge or replace the battery, and the injection is prohibited when the remaining battery power is lower than the set threshold;

 [102] 5), set the injection moment reminder, including buzzer sound prompt and screen display;

 [103] 6) When the set dose, time, etc. do not meet the established rules, the error message is displayed through the display screen, and the current set parameters are discarded. The predetermined rule may be the warning threshold set in the syringe in advance, or The user sets the previous dose and time;

 [104] 7), When the injection time has not arrived, or when attempting to continuously inject during the specified time period, the injection will be prohibited and a warning message will be displayed on the display.

 9, FIG. 10, FIG. 11 is an embodiment of a drive assembly of a medicament injector of the present invention, comprising a gear housing 51, a gearbox cover 52, a gearbox body 51 and a gearbox cover 52. a reduction gear set 53 in the cavity, a photoelectric switch for detecting a gear rotation angle of the reduction gear set 53, a DC motor 54, a DC stabilized power supply for supplying the DC motor 54, and a control unit for controlling the operation of the DC motor 54, on the gear housing 51 A shaft screw 55 for driving the electronic insulin syringe is provided, and the DC motor 54 is driven to rotate by the reduction gear set 53 to rotate the shaft screw 55. The reduction gear set 53 includes three gear shafts arranged in parallel, which are respectively a high speed gear shaft 531, an intermediate gear shaft 532 and a low speed gear shaft 533. Each gear shaft is provided with an integrated large gear and a pinion gear, and the same gear shaft The upper large gear and the small gear rotate at the same angular speed, the pinion gear of the high speed gear shaft 531 meshes with the large gear of the intermediate gear shaft 532, the pinion gear of the intermediate gear shaft 532 meshes with the large gear of the low speed gear shaft 533, and the photoelectric switch is disposed at the high speed gear The large gear of the shaft 531. The reduction gear ratio of the reduction gear set 53 of the drive assembly is large, i=50~500, the photoelectric switch detects the rotation angle of the large gear of the high speed gear shaft 531, and feeds back the data to the control unit, and the operation of the DC motor 54 is controlled by the control unit. , to achieve precision injection.

 [106] An embodiment of the gear shaft: the high speed gear shaft 531, the intermediate gear shaft 532, and the low speed gear shaft 533 are integrally formed with the gear housing 51. The gear box cover 52 is provided with a high speed gear shaft 531 and an intermediate gear. A shaft hole 532 and a shaft hole corresponding to the low speed gear shaft 533. Although the integral structure of the gear shaft and the gear housing 51 is difficult to manufacture, the entire apparatus is assembled.

 [107] Another embodiment of the gear shaft: The gear housing 51 and the gear case cover 52 are correspondingly provided with shaft holes for mounting the high speed gear shaft 531, the intermediate gear shaft 532 and the low speed gear shaft 533. Although the split structure of the gear shaft and the gear case 51 allows the entire machine to be assembled, the equipment manufacturing is difficult.

[108] The DC motor 54 is a hollow cup motor, and the gear housing 51 has a fixed hollow cup. The motor mounting hole 511 of the machine is installed in the motor mounting hole 511 and can be fixed by a glue or fixed by a heat shrinkable tube. This ensures the stability of the operation of the DC motor 54 and does not cause gear meshing due to the skew of the motor center. The outer periphery of the motor mounting hole 511 is provided with a reinforcing rib 512. The hollow cup motor has an output shaft, and the output shaft is provided with a gear meshingly coupled with the large gear of the high speed shaft 531. Hollow cup motors are DC, permanent magnet and servo micro-motors with outstanding energy-saving features, sensitive and convenient control characteristics and stable operating characteristics.

 [109] In order to secure the shaft screw 55, one end of the shaft screw 55 is provided with a toothed disc 56, and the shaft screw 55 is mounted on the gear housing 51 via the toothed disc 56, and the toothed disc 56 has a low speed gear shaft 533. a pinion meshing gear 561 and a ring sleeve 562 for mounting the shaft screw 55. The ring sleeve 562 is provided with a toothed seat 563. One end of the toothed disk 56 is mounted on the gear case 51 through the toothed seat 563, and the other of the toothed plate 56 One end is mounted to the gear case cover 52 via a bearing 564. The bearing 564 offsets the axial thrust of the shaft screw 55, avoiding the loss of the rotational torque due to the end face friction, and even the stuck.

 The gear housing 51 is provided with a positioning rib 513 for connecting the electronic insulin syringe to the housing of the shaft screw 55. The locating rib 513 ensures the reliability of the drive assembly and the electronic insulin syringe assembly.

 12, FIG. 13, and FIG. 14 are another embodiment of the driving assembly of the medicament injector of the present invention. In this embodiment, the driving assembly is a gear box separated type, including a permanent magnet type stepping motor 71 and a gear reduction box. 72. A shaft screw 73 and a control unit. The gear reduction box 72 has a reduction gear set. The input end of the reduction gear set of the gear reduction box 72 is connected with the permanent magnet type stepping motor 71, and the output end of the reduction gear set is output. The shaft screw 73 is drivingly connected, and the control unit is connected to the permanent magnet type stepping motor 71.

The permanent magnet type stepping motor 71 includes a casing assembly 711, a cover plate assembly 714 integrally formed with the casing assembly 711, and a stator assembly 712 disposed in a cavity formed by the casing assembly 711 and the cover plate assembly 714. The rotor assembly 713 has two ends of the rotor assembly 713 respectively coupled to the casing assembly 711 and the cover assembly 714 via a bearing support. One end of the rotor assembly 713 extends from the cover assembly 714 and is provided with an input gear coupled to the reduction gear set. 715, the other end of the rotor assembly 713 extends out of the casing assembly 711 and is provided with a photoelectric sensing disk 716 and a photoelectric switch 717 for sensing the rotation angle of the photoelectric sensing disk 716. The photoelectric switch 717 is electrically connected to the control unit. When the permanent magnet type stepping motor 71 rotates, the photoelectric induction disk 716 rotates synchronously, and the photoelectric switch 717 detects the angle of rotation of the photoelectric induction disk 716 and feeds back information to the control unit, so that the control unit accurately controls the rotation of the permanent magnet type stepping motor 71. Angle, make the electronic pancreas The island syringe meets the microinjection requirements for high dose accuracy.

 [113] The gear reduction box 72 has a casing 721 and a cover plate 723 integrally coupled with the casing 721. The reduction gear set includes two high-speed gear shafts 722-1 and a low-speed gear shaft 722-2 arranged in parallel, and a high-speed gear shaft. Both the 722-1 and the low-speed gear shaft 722-2 are equipped with integral large gears and pinions. The large gears and pinions on the same gear shaft rotate at the same angular speed, and the small gears and low-speed gears on the high-speed gear shaft 722-1. The large gears on the shaft 722-2 are engaged. The two-stage pinion drives the large gear, and the transmission ratio is large to increase the torque output from the shaft screw 73, thereby achieving high thrust injection requirements. The shaft screw 73 can be centered out of the shaft or eccentrically out of the shaft. Simply change the high speed gear shaft 722-1 and the low speed gear shaft 722-2 position to engage the gears. Figure 13 is a schematic view showing the structure of the center output shaft, and Figure 14 is a schematic view of the transmission after the reduction gear set is deployed.

 [114] A mounting hole is formed in the end surface of the casing 721, and the input gear 715 of the permanent magnet type stepping motor 71 passes through the mounting hole to mesh with the large gear on the high speed gear shaft 722-1, and the cover of the permanent magnet type stepping motor 71 The end surface of the plate assembly 714 is fixedly connected to the end surface of the casing 721 of the gear reduction box 72. The cover plate 723 is provided with a bearing hole for mounting the shaft screw 73. The bearing hole is provided with an interference mounting rolling bearing 731, and the interference of the shaft screw 73 is installed. In the bore of the rolling bearing 731, the take-up screw 73 extends into the cover 723 and is fitted with an output gear 732 which meshes with the pinion on the low speed gear shaft 722-2. The two ends of the gear reduction box 72 are a permanent magnet type stepping motor 71 and an output shaft screw 73, and the whole structure is simple, and the volume is small and easy to operate. The position of the permanent magnet stepping motor 71 and the shaft screw 73 at both ends of the gear reduction box 72 can be changed, and only the position of the reduction gear set in the gear reduction box 72 can be changed.

 [115] Rolling axis 7| 731 is a double-column scrolling axis or two parallel rolling axes ^. Reducing the interference of radial forces improves operational stability.

Claims

Rights request

 A medicament injector comprising a syringe housing, characterized by: further comprising

 a control system, the control system being a microprocessor circuit board;

 In the injection system, the injection system includes an injection needle, an injection assembly and an injection advancement portion, and the injection assembly includes an injection needle fixing sleeve for fixing the injection needle, a drug cartridge and a piston, wherein the injection needle fixing sleeve and the drug cartridge are The integrated structure, the piston is disposed in the liquid cartridge, and the injection propulsion portion comprises a screw and an ejector tube, wherein the screw is disposed in the ejector tube, and a sliding threaded connection is arranged between the ejector tube and the ejector tube passes the sliding fitting The threaded connection moves linearly with the rotation of the screw, and the piston is connected with the ejector tube; the motor drive system, the motor drive system includes an induction device and a stepper motor assembly, and the sensing device includes an induction disk and a photoelectric sensor, and the sensing disk The disk edge is evenly distributed with a plurality of teeth. The sensing disk is fixedly connected with the output shaft of the stepping motor and rotates synchronously with the output shaft. The sensing optical path of the photoelectric sensor corresponds to the position of the sensing disk tooth to monitor the rotation of the sensing disk.

 The control system is electrically coupled to the stepper motor and the photosensor, respectively.

 2. The medicament injector according to claim 1, wherein: the injection propulsion portion further comprises an ejector tube protection sleeve, the ejector tube is disposed in the ejector tube protection sleeve, and is slidable relative to the ejector tube protection sleeve .

 The drug injector according to claim 2, wherein the ejector tube and the ejector tube protector slide between the T-shaped grooves and the projections which are fitted to each other.

 4. The medicament injector of claim 3, wherein: the medicament injector further comprises a display screen, a button, a buzzer and a USB interface, and is respectively connected to the control system.

5. A method of controlling a medicament injector for controlling a medicament injector according to claim 1, comprising: the following steps: (1) a microprocessor of the control system issues a pulse signal, and the stepper motor is controlled according to the setting The corresponding direction rotates the corresponding angle and the step angle, and the stepping motor drives the screw to rotate accordingly. Under the relative action of the sliding thread, the ejector tube moves axially with the screw rotation, and pushes the piston in the liquid cartridge. Move the liquid medicine injection, the angular displacement of the stepping motor rotates and the linear displacement of the piston has a linear relationship; (2) the control system judges the working state of the stepping motor and the set working state according to the monitoring signal of the photoelectric sensor , to determine whether the motor is working properly, when the motor stops, turns, or rotates at an abnormal speed due to abnormal conditions, an alarm is issued; (3) the control system is connected to the display, buttons, buzzer, and USB interface, and the display is used for the injector Status and injection data display, button for setting Set the working parameters of the syringe, the buzzer is used to remind, the USB interface is used to connect and charge with the computer equipment.

 6. The control method according to claim 5, wherein: the microprocessor is provided with a flash memory, and stores a control set in the following manner: (1) In the injection mode, the shortcut mode and the time sharing mode are included. In the shortcut mode, after the injection dose setting is completed, the set injection dose parameter is directly stored in the flash memory, and the saved injection dose parameter is directly read from the flash memory as the current before the injection dose is reset. The dose parameter of the injection; in the time-sharing mode, the corresponding injection dose parameter is set corresponding to different time, and the corresponding time reminder is set; (2) the injection information is stored, and the history of the recent times is saved in the flash memory by using the FIFO mode. Injection data, including injection start time, injection dose and injection mode; (3) Display the information stored in the flash memory one by one by button selection, including historical injection data, or transfer the stored information to the upper computer for display through the USB interface And inspection; (4) When the interval between two injections is too short, injection is prohibited. Set the injection time interval threshold. When the time interval from the last injection is less than the threshold, the operation is prohibited. (5) The power saving mode sets a time period. When there is no operation within the time period, it automatically enters the low level. Power consumption state, when the button operation is encountered, it automatically jumps out of the low power state and enters the normal working state.

 7. The control method according to claim 6, further comprising the following reminding manner: (1) When an injection ends, the buzzer reminds the end of the injection, and displays the injection on the display screen. Set the dose and prompt the end of the injection; (2) The control system calculates the remaining dose in the liquid cartridge according to the stored injection information, and when the remaining dose is less than the injection dose set this time, an alarm is given to remind the replacement of the liquid cartridge. When the dose in the cartridge is exhausted, the control system controls the stepper motor to automatically return to the initial position to replace the new cartridge; (3) monitor the voltage of the battery in real time, and the voltage information is transmitted to the control system through A/D conversion. When it is less than the set threshold, the alarm prompts to charge or replace the battery, and prohibits the injection when the remaining battery power is lower than the threshold; (4) Remind the injection time, prompt the injection time through the display or buzzer.

 8. A drive assembly for a medicament injector, comprising: a reduction gear box, a photoelectric switch for detecting a rotation angle of the reduction gear set, and a DC motor and a corresponding power supply and control unit thereof, the reduction gear box The output shaft is epitaxially extended to the screw of claim 1.

9. The drive assembly according to claim 8, wherein: said reduction gear set comprises three gear shafts arranged in parallel, respectively a high speed gear shaft, an intermediate gear shaft and a low speed gear shaft, each tooth The large and small gears are arranged on the axle, and the large gear and the small gear rotate on the same gear shaft at the same angular speed, and the photoelectric switch is correspondingly disposed at the large gear of the high speed gear shaft.

 10. A drive assembly according to any one of claims 8 or 9, wherein: said DC motor is a hollow cup motor or a permanent magnet stepper motor.