WO2011156000A3 - Use of il-4/il-13 antagonists to treat eosinophilic disorders - Google Patents
Use of il-4/il-13 antagonists to treat eosinophilic disorders Download PDFInfo
- Publication number
- WO2011156000A3 WO2011156000A3 PCT/US2011/001050 US2011001050W WO2011156000A3 WO 2011156000 A3 WO2011156000 A3 WO 2011156000A3 US 2011001050 W US2011001050 W US 2011001050W WO 2011156000 A3 WO2011156000 A3 WO 2011156000A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antagonists
- eosinophic
- provides methods
- disorders
- eosinophilic disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
Abstract
The present invention provides methods for treating eosinophic disorders, including eosinophic asthma, by administering compositions that act as antagonists to IL 4 and IL-13, in particular antisense, RNAi, antibody, and mutant human interleukin-4 (IL-4) antagonists. The invention also provides methods and kits for determining the major allele in certain SNPs in the IL-4 receptor α polypeptide (IL-4RA) as an indication of likely response to IL-4/IL-13 antagonist treatment.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39717410P | 2010-06-07 | 2010-06-07 | |
US61/397,174 | 2010-06-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011156000A2 WO2011156000A2 (en) | 2011-12-15 |
WO2011156000A3 true WO2011156000A3 (en) | 2013-11-07 |
Family
ID=45098570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/001050 WO2011156000A2 (en) | 2010-06-07 | 2011-06-07 | Use of il-4/il-13 antagonists to treat eosinophilic disorders |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011156000A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230167770A (en) * | 2014-02-21 | 2023-12-11 | 사노피 바이오테크놀로지 | Methods for treating or preventing asthma by administering an il-4r antagonist |
MX2016013372A (en) * | 2014-04-11 | 2017-01-26 | Novartis Ag | Methods of selectively treating asthma using il-13 antagonists. |
US9815894B2 (en) * | 2014-09-08 | 2017-11-14 | Cephalon, Inc. | Use of reslizumab to treat moderate to severe eosinophilic asthma |
US20230151426A1 (en) * | 2021-09-30 | 2023-05-18 | Regeneron Pharmaceuticals, Inc. | Reticulocalbin-3 (RCN3) Variants And Treatment Of Asthma With Interleukin-4 Receptor Alpha (IL4R) Antagonists |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090010874A1 (en) * | 2003-08-29 | 2009-01-08 | Aerovance, Inc. | Modified il-4 mutein receptor antagonists |
US20090291981A1 (en) * | 2008-05-23 | 2009-11-26 | Amira Pharmaceuticals, Inc. | 5-Lipoxygenase-Activating Protein Inhibitor |
-
2011
- 2011-06-07 WO PCT/US2011/001050 patent/WO2011156000A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090010874A1 (en) * | 2003-08-29 | 2009-01-08 | Aerovance, Inc. | Modified il-4 mutein receptor antagonists |
US20090291981A1 (en) * | 2008-05-23 | 2009-11-26 | Amira Pharmaceuticals, Inc. | 5-Lipoxygenase-Activating Protein Inhibitor |
Non-Patent Citations (4)
Title |
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BORISH, L.C. ET AL.: "Efficacy Of Soluble IL-4 Receptor For The Treatment Of Adults With Asthma", J ALLERGY CLIN IMMUNOL., vol. 107, no. 6, June 2001 (2001-06-01), pages 963 - 970 * |
LECKIE, M.J. ET AL.: "Effects Of An Interleukin-5 Blocking Monoclonal Antibody On Eosinophils, Airway Hyper-Responsiveness, And The Late Asthmatic Response", THE LANCET, vol. 356, 23 December 2000 (2000-12-23), pages 2144 - 2148 * |
UMHS ASTHMA QUALITY IMPROVEMENT STEERING COMMITTEE: "Quick Reference Charts For The Classification And Stepwise Treatment Of Asthma", ADAPTED FROM 2007 NHLBI GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF ASTHMA EXPERT PANEL REPORT 3, 30 June 2008 (2008-06-30) * |
YING, S. ET AL.: "Associations Between IL-13 And IL-4 (mRNA And Protein), Vascular Cell Adhesion Molecule-1 Expression, And The Infiltration Of Eosinophils, Macrophages, And T Cells In Allergen-Induced Late-Phase Cutaneous Reactions In Atopic Subjects", THE JOURNAL OF IMMUNOLOGY, vol. 158, no. 10, 10 February 1997 (1997-02-10), pages 5050 - 5057 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011156000A2 (en) | 2011-12-15 |
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