WO2011154711A8 - Peptide-carrying nanoparticles - Google Patents

Peptide-carrying nanoparticles Download PDF

Info

Publication number
WO2011154711A8
WO2011154711A8 PCT/GB2011/000882 GB2011000882W WO2011154711A8 WO 2011154711 A8 WO2011154711 A8 WO 2011154711A8 GB 2011000882 W GB2011000882 W GB 2011000882W WO 2011154711 A8 WO2011154711 A8 WO 2011154711A8
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
carrying nanoparticles
nanoparticles
corona
core
Prior art date
Application number
PCT/GB2011/000882
Other languages
French (fr)
Other versions
WO2011154711A1 (en
Inventor
Thomas Rademacher
Phillip Williams
Christof Bachmann
Africa Garcia Barrientos
Ester De Torres Dominguez
Javier Del Campo Menoyo
Original Assignee
Midatech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Midatech Limited filed Critical Midatech Limited
Priority to AU2011263546A priority Critical patent/AU2011263546B2/en
Priority to CA2802031A priority patent/CA2802031C/en
Priority to JP2013513749A priority patent/JP5755732B2/en
Priority to CN201180035108.9A priority patent/CN103002922B/en
Priority to ES11728365T priority patent/ES2718303T3/en
Priority to EP11728365.5A priority patent/EP2579898B1/en
Publication of WO2011154711A1 publication Critical patent/WO2011154711A1/en
Priority to CN201280036039.8A priority patent/CN103732215B/en
Priority to CA2838762A priority patent/CA2838762A1/en
Priority to PCT/US2012/041569 priority patent/WO2012170828A1/en
Priority to EP12796229.8A priority patent/EP2717858B1/en
Priority to JP2014514884A priority patent/JP6040231B2/en
Priority to US13/492,040 priority patent/US8790704B2/en
Priority to AU2012267605A priority patent/AU2012267605C1/en
Publication of WO2011154711A8 publication Critical patent/WO2011154711A8/en
Priority to US14/048,286 priority patent/US9474687B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nanoparticles comprising: (i) a core comprising a metal; (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein at least one of said ligands comprises a carbohydrate moiety; and (iii) at least one peptide bound to the corona.
PCT/GB2011/000882 2010-06-10 2011-06-10 Peptide-carrying nanoparticles WO2011154711A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU2011263546A AU2011263546B2 (en) 2010-06-10 2011-06-10 Peptide-carrying nanoparticles
CA2802031A CA2802031C (en) 2010-06-10 2011-06-10 Peptide-carrying nanoparticles
JP2013513749A JP5755732B2 (en) 2010-06-10 2011-06-10 Peptide-supported nanoparticles
CN201180035108.9A CN103002922B (en) 2010-06-10 2011-06-10 The nano-particle of carry peptides
ES11728365T ES2718303T3 (en) 2010-06-10 2011-06-10 Nanoparticles that carry peptides
EP11728365.5A EP2579898B1 (en) 2010-06-10 2011-06-10 Peptide-carrying nanoparticles
AU2012267605A AU2012267605C1 (en) 2011-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same
CN201280036039.8A CN103732215B (en) 2011-06-10 2012-06-08 Combine peptide nanoparticles and mix its delivery system
CA2838762A CA2838762A1 (en) 2011-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same
PCT/US2012/041569 WO2012170828A1 (en) 2011-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same
EP12796229.8A EP2717858B1 (en) 2011-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same
JP2014514884A JP6040231B2 (en) 2011-06-10 2012-06-08 Peptide-nanoparticle combination and delivery system incorporating it
US13/492,040 US8790704B2 (en) 2010-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same
US14/048,286 US9474687B2 (en) 2010-06-10 2013-10-08 Combination peptide-nanoparticles and delivery systems incorporating same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35338010P 2010-06-10 2010-06-10
US61/353,380 2010-06-10
GB61/353,380 2010-06-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/039979 Continuation-In-Part WO2011156711A1 (en) 2010-06-10 2011-06-10 Nanoparticle film delivery systems

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/157,836 Continuation-In-Part US8974826B2 (en) 2010-06-10 2011-06-10 Nanoparticle film delivery systems
US13/492,040 Continuation-In-Part US8790704B2 (en) 2010-06-10 2012-06-08 Combination peptide-nanoparticles and delivery systems incorporating same

Publications (2)

Publication Number Publication Date
WO2011154711A1 WO2011154711A1 (en) 2011-12-15
WO2011154711A8 true WO2011154711A8 (en) 2012-07-26

Family

ID=44627635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/000882 WO2011154711A1 (en) 2010-06-10 2011-06-10 Peptide-carrying nanoparticles

Country Status (8)

Country Link
US (1) US8568781B2 (en)
EP (1) EP2579898B1 (en)
JP (2) JP5755732B2 (en)
CN (1) CN103002922B (en)
AU (1) AU2011263546B2 (en)
CA (1) CA2802031C (en)
ES (1) ES2718303T3 (en)
WO (1) WO2011154711A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105188765A (en) * 2013-03-04 2015-12-23 Mida科技有限公司 Nanoparticle peptide compositions

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ITRM20030376A1 (en) 2003-07-31 2005-02-01 Univ Roma PROCEDURE FOR THE ISOLATION AND EXPANSION OF CARDIOC STAMIN CELLS FROM BIOPSIA.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
WO2011156711A1 (en) * 2010-06-10 2011-12-15 Schobel Alexander M Nanoparticle film delivery systems
US8790704B2 (en) * 2010-06-10 2014-07-29 Monosol Rx, Llc Combination peptide-nanoparticles and delivery systems incorporating same
US9370490B2 (en) 2012-02-28 2016-06-21 Loma Linda University Methods for the production, modification and use of metallic nanoparticles
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
GB201301991D0 (en) 2013-02-05 2013-03-20 Midatech Ltd Permeation enhanced active-carrying nanoparticles
GB201302427D0 (en) 2013-02-12 2013-03-27 Midatech Ltd Nanoparticle delivery compositions
GB201303787D0 (en) * 2013-03-04 2013-04-17 Midatech Ltd Nanoparticle peptide compositions
ES2877898T3 (en) 2013-03-14 2021-11-17 Univ California Thiosaccharide mucolytic agents
CN103289985A (en) * 2013-05-10 2013-09-11 福州大学 Protein doped organic-inorganic hybridized flower-shaped nano material
CN103275965A (en) * 2013-05-22 2013-09-04 武汉理工大学 Self-recovery soft-embedding cell immobilization system with multiple functions and preparation method thereof
GB201401706D0 (en) 2014-01-31 2014-03-19 Midatech Ltd Nanoparticle-insulin and insulin analogue compositions
AU2015327812B2 (en) 2014-10-03 2021-04-15 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
GB201420080D0 (en) * 2014-11-11 2014-12-24 Midatech Ltd And Q Chip Ltd Sustained release encapsulated nanoparticles
US10688125B2 (en) 2014-12-23 2020-06-23 Midatech Ltd. Nanoparticles and their use in cancer therapy
GB2541166A (en) 2015-07-24 2017-02-15 Midatech Ltd Nanoparticle-based liver-targeting therapy and imaging
WO2017049125A1 (en) 2015-09-16 2017-03-23 La Jolla Nanomedical A cellular activity targeted nanoparticle system and methods of producing the nanoparticle system
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
GB2548084A (en) * 2016-02-26 2017-09-13 Midatech Ltd Nanoparticle production
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
GB201701745D0 (en) * 2017-02-02 2017-03-22 Midatech Ltd Nanoparticle-based liver-targeting therapy and imaging
AU2018255346B2 (en) 2017-04-19 2024-05-02 Capricor Inc Methods and compositions for treating skeletal muscular dystrophy
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
JP2021509400A (en) * 2018-01-06 2021-03-25 イマージェクス ヴァクシンズ ホールディング リミテッドＥｍｅｒｇｅｘ Ｖａｃｃｉｎｅｓ Ｈｏｌｄｉｎｇ Ｌｉｍｉｔｅｄ MHC class I-related peptides for the prevention and treatment of multiple flaviviruses
KR102594366B1 (en) 2018-11-07 2023-10-27 시어 인코퍼레이티드 Compositions, methods and systems for protein corona analysis and their uses
GB201820470D0 (en) 2018-12-14 2019-01-30 Midatech Ltd Antifolate-carrying nanoparticles and their use in medicine
GB201820471D0 (en) 2018-12-14 2019-01-30 Midatech Ltd Nanoparticle-based therapy of inflammatory disorders
WO2021087407A1 (en) * 2019-11-02 2021-05-06 Seer, Inc. Systems for protein corona analysis
EP3909612A1 (en) 2020-05-12 2021-11-17 Life Science Inkubator Betriebs GmbH & Co. KG Composition of nanoparticles
CN113289014B (en) * 2021-05-10 2022-05-17 上海交通大学 Zwitterionic polypeptide/gallic acid/iron coordination nanoparticle with ultra-small particle size as well as preparation method and application thereof
CN113358800A (en) * 2021-05-26 2021-09-07 吉林化工学院 Magnetic nitrogen-doped carbon material and method for extracting and analyzing phthalic acid ester in plastic bottled water by using same

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FR2876103B1 (en) * 2004-10-01 2008-02-22 Aventis Pharma Sa NOVEL BIS-AZAINDOL DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS INHIBITORS OF KINASES
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GB0820309D0 (en) * 2008-11-06 2008-12-17 Middlesex University Higher Ed Detection of cancer
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WO2011156711A1 (en) * 2010-06-10 2011-12-15 Schobel Alexander M Nanoparticle film delivery systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105188765A (en) * 2013-03-04 2015-12-23 Mida科技有限公司 Nanoparticle peptide compositions

Also Published As

Publication number Publication date
JP5933659B2 (en) 2016-06-15
ES2718303T3 (en) 2019-07-01
JP2015038091A (en) 2015-02-26
AU2011263546A1 (en) 2013-01-31
AU2011263546B2 (en) 2015-01-22
US20120171291A1 (en) 2012-07-05
JP5755732B2 (en) 2015-07-29
US8568781B2 (en) 2013-10-29
CN103002922A (en) 2013-03-27
CA2802031C (en) 2015-05-12
CN103002922B (en) 2015-11-25
WO2011154711A1 (en) 2011-12-15
EP2579898B1 (en) 2019-01-09
CA2802031A1 (en) 2011-12-15
EP2579898A1 (en) 2013-04-17
JP2013528202A (en) 2013-07-08

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