WO2011154505A3 - Complex product comprising a cellular carrier and a cytoxic chemotherapeutic drug - Google Patents

Complex product comprising a cellular carrier and a cytoxic chemotherapeutic drug Download PDF

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Publication number
WO2011154505A3
WO2011154505A3 PCT/EP2011/059626 EP2011059626W WO2011154505A3 WO 2011154505 A3 WO2011154505 A3 WO 2011154505A3 EP 2011059626 W EP2011059626 W EP 2011059626W WO 2011154505 A3 WO2011154505 A3 WO 2011154505A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytoxic
chemotherapeutic drug
complex product
cellular carrier
physiological
Prior art date
Application number
PCT/EP2011/059626
Other languages
French (fr)
Other versions
WO2011154505A2 (en
Inventor
Augusto Pessina
Giulio Alessandri
Original Assignee
Fondazione I.R.C.C.S. Istituto Neurologico "Carlo Besta"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fondazione I.R.C.C.S. Istituto Neurologico "Carlo Besta" filed Critical Fondazione I.R.C.C.S. Istituto Neurologico "Carlo Besta"
Publication of WO2011154505A2 publication Critical patent/WO2011154505A2/en
Publication of WO2011154505A3 publication Critical patent/WO2011154505A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The complex product comprises a cellular carrier including physiological mesenchymal cells isolated from a mammal and possessing at least one marker selected from among CD13, CD90, CD73, CD105 and CD14, and a cytoxic chemotherapeutic drug internalized by said physiological mesenchymal cells in a physiological manner in a high concentration which is pharmacologically efficacious against a sensitive cellular target.
PCT/EP2011/059626 2010-06-11 2011-06-09 Complex product comprising a cellular carrier and a cytoxic chemotherapeutic drug WO2011154505A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2010A001064A IT1401457B1 (en) 2010-06-11 2010-06-11 CARRIER OF CELL TYPE FOR THE SIGHTED TRANSPORT OF AT LEAST ONE MOLECULE AND / OR AT LEAST A MOLECULAR COMPOUND AT LEAST ONE TARGET CELL IN A HUMAN OR NON-HUMAN MAMMALY
ITMI2010A001064 2010-06-11

Publications (2)

Publication Number Publication Date
WO2011154505A2 WO2011154505A2 (en) 2011-12-15
WO2011154505A3 true WO2011154505A3 (en) 2012-06-28

Family

ID=43414347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/059626 WO2011154505A2 (en) 2010-06-11 2011-06-09 Complex product comprising a cellular carrier and a cytoxic chemotherapeutic drug

Country Status (2)

Country Link
IT (1) IT1401457B1 (en)
WO (1) WO2011154505A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700043316A1 (en) * 2017-04-20 2018-10-20 Lipogems Int S P A DRUG DELIVERY SYSTEM

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541024B1 (en) * 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO2005079854A1 (en) * 2004-02-02 2005-09-01 Engeneic Molecular Delivery Pty Ltd. Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
WO2007037653A1 (en) * 2005-09-29 2007-04-05 Ajou University Industry-Academic Cooperation Foundation Use of mesenchymal stem cells genetically modified to express a suicide gene for treating a cancer
WO2008012695A2 (en) * 2006-06-23 2008-01-31 Engeneic Molecular Delivery Pty Ltd. Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
WO2009009591A2 (en) * 2007-07-09 2009-01-15 Kansas State University Research Foundation Use of cells to facilitate targeted delivery of nanoparticle therapies
US20090274630A1 (en) * 2008-05-01 2009-11-05 National Health Research Institutes Red blood cell-derived vesicles as a nanoparticle drug delivery system
US20100041133A1 (en) * 2008-08-13 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
EP2182054A1 (en) * 2008-10-16 2010-05-05 Universita' Degli Studi di Bari Process for identification and isolation of mesenchymal cells with marked bone regenerative ability
WO2011024172A2 (en) * 2009-08-27 2011-03-03 Technion Research & Development Foundation Ltd. Liposomal compositions and uses of same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541024B1 (en) * 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO2005079854A1 (en) * 2004-02-02 2005-09-01 Engeneic Molecular Delivery Pty Ltd. Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
WO2007037653A1 (en) * 2005-09-29 2007-04-05 Ajou University Industry-Academic Cooperation Foundation Use of mesenchymal stem cells genetically modified to express a suicide gene for treating a cancer
WO2008012695A2 (en) * 2006-06-23 2008-01-31 Engeneic Molecular Delivery Pty Ltd. Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
WO2009009591A2 (en) * 2007-07-09 2009-01-15 Kansas State University Research Foundation Use of cells to facilitate targeted delivery of nanoparticle therapies
US20090274630A1 (en) * 2008-05-01 2009-11-05 National Health Research Institutes Red blood cell-derived vesicles as a nanoparticle drug delivery system
US20100041133A1 (en) * 2008-08-13 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
EP2182054A1 (en) * 2008-10-16 2010-05-05 Universita' Degli Studi di Bari Process for identification and isolation of mesenchymal cells with marked bone regenerative ability
WO2011024172A2 (en) * 2009-08-27 2011-03-03 Technion Research & Development Foundation Ltd. Liposomal compositions and uses of same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ARBAB ALI S ET AL: "Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, vol. 104, no. 4, 2004, pages 1217 - 1223, XP002453596, ISSN: 0006-4971, DOI: DOI:10.1182/BLOOD-2004-02-0655 *
CHEGLAKOV I B ET AL: "Vital dye Dil and fluorescent magnetic microparticles do not affect the phenotype of mesenchymal stem cells from human amnion and their differentiation capacity", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 145, no. 4, April 2008 (2008-04-01), pages 504 - 510, XP002619135, ISSN: 0007-4888, DOI: 10.1007/s10517-008-0129-z *
DEMBINSKI J L ET AL: "Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells", CANCER GENE THERAPY, vol. 17, no. 4, April 2010 (2010-04-01), pages 289 - 297, XP002619136, ISSN: 0929-1903, DOI: 10.1038/CGT.2009.67 *
FRITZ VANESSA ET AL: "Mesenchymal stem cells: an emerging tool for cancer targeting and therapy", CURRENT STEM CELL RESEARCH & THERAPY, vol. 3, no. 1, 1 January 2008 (2008-01-01), pages 32 - 42, XP009135555, ISSN: 1574-888X *
KOMAROVA SVETLANA ET AL: "Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses", MOLECULAR CANCER THERAPEUTICS, vol. 5, no. 3, 1 March 2006 (2006-03-01), pages 755 - 766, XP002590129, ISSN: 1535-7163 *
MOSCOSO I ET AL: "Analysis of Different Routes of Administration of Heterologous 5-Azacytidine-Treated Mesenchymal Stem Cells in a Porcine Model of Myocardial Infarction", TRANSPLANTATION PROCEEDINGS, vol. 41, no. 6, 1 July 2009 (2009-07-01), pages 2273 - 2275, XP026520199, ISSN: 0041-1345, [retrieved on 20090826], DOI: DOI:10.1016/J.TRANSPROCEED.2009.06.011 *
TSYB A F ET AL: "Morphofunctional study of the therapeutic efficacy of human mesenchymal and neural stem cells in rats with diffuse brain injury.", CELL TECHNOLOGIES IN BIOLOGY AND MEDICINE, vol. 147, no. 1, January 2009 (2009-01-01), pages 132 - 146, XP002619138, ISSN: 0007-4888, DOI: 007-488/09/1471-0132 *
WANG L ET AL: "Effects of cytotoxic agents on proliferation and differentiation of mesenchymal stem cells from mouse lung and compact bone", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH, vol. 13, no. 32, 6 August 2009 (2009-08-06), pages 6279 - 6283, XP008131610, ISSN: 1673-8225, DOI: 10.3969/J.ISSN.1673-8225.2009.32.015 *
YU Y ET AL: "Migration and localization of bone marrow mesenchymal stem cells labeled by DAPI in the brain of glioma rat models", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH, vol. 14, no. 23, 4 June 2010 (2010-06-04), pages 4243 - 4246, XP008131580, ISSN: 1673-8225, DOI: 10.3969/J.ISSN.1673-8225.2010.23.015 *

Also Published As

Publication number Publication date
IT1401457B1 (en) 2013-07-26
WO2011154505A2 (en) 2011-12-15
ITMI20101064A1 (en) 2011-12-12

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