WO2011152884A9 - 14 gene signature distinguishes between multiple myeloma subtypes - Google Patents

14 gene signature distinguishes between multiple myeloma subtypes Download PDF

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Publication number
WO2011152884A9
WO2011152884A9 PCT/US2011/001020 US2011001020W WO2011152884A9 WO 2011152884 A9 WO2011152884 A9 WO 2011152884A9 US 2011001020 W US2011001020 W US 2011001020W WO 2011152884 A9 WO2011152884 A9 WO 2011152884A9
Authority
WO
WIPO (PCT)
Prior art keywords
multiple myeloma
gene signature
signature distinguishes
subtypes
myeloma subtypes
Prior art date
Application number
PCT/US2011/001020
Other languages
French (fr)
Other versions
WO2011152884A2 (en
Inventor
John D. Shaughnessy, Jr.
Barthel Barlogie
Original Assignee
Board Of Trustees Of The University Of Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Trustees Of The University Of Arkansas filed Critical Board Of Trustees Of The University Of Arkansas
Publication of WO2011152884A2 publication Critical patent/WO2011152884A2/en
Publication of WO2011152884A9 publication Critical patent/WO2011152884A9/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
PCT/US2011/001020 2010-06-04 2011-06-06 14 gene signature distinguishes between multiple myeloma subtypes WO2011152884A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39691710P 2010-06-04 2010-06-04
US61/396,917 2010-06-04

Publications (2)

Publication Number Publication Date
WO2011152884A2 WO2011152884A2 (en) 2011-12-08
WO2011152884A9 true WO2011152884A9 (en) 2012-04-12

Family

ID=45067222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/001020 WO2011152884A2 (en) 2010-06-04 2011-06-06 14 gene signature distinguishes between multiple myeloma subtypes

Country Status (1)

Country Link
WO (1) WO2011152884A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016066665A1 (en) * 2014-10-28 2016-05-06 Institut Gustave Roussy Improved treatments of cancer resistant to taxoids
CA3067730A1 (en) * 2017-07-21 2019-01-24 Liquid Biopsy Research LLC Methods for detection of plasma cell dyscrasia

Also Published As

Publication number Publication date
WO2011152884A2 (en) 2011-12-08

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