WO2011151618A3 - Compounds for the treatment of clostridium difficile associated disease (cdad) - Google Patents
Compounds for the treatment of clostridium difficile associated disease (cdad) Download PDFInfo
- Publication number
- WO2011151618A3 WO2011151618A3 PCT/GB2011/000828 GB2011000828W WO2011151618A3 WO 2011151618 A3 WO2011151618 A3 WO 2011151618A3 GB 2011000828 W GB2011000828 W GB 2011000828W WO 2011151618 A3 WO2011151618 A3 WO 2011151618A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- treatment
- clostridium difficile
- cdad
- associated disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Disclosed are compounds of formula (I): or a pharmaceutically acceptable N-oxide, salt, hydrate, solvate, complex, bioisostere, metabolite or prodrug thereof, which are of use in the treatment of infection with, and diseases caused by, Clostridium difficile.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1009094.2A GB201009094D0 (en) | 2010-06-01 | 2010-06-01 | Compounds for the treatment of closridium difficile-associated disease |
GB1009094.2 | 2010-06-01 | ||
GBGB1106970.5A GB201106970D0 (en) | 2011-04-27 | 2011-04-27 | Compounds for the treatment of clostridium difficile-associated disease |
GB1106970.5 | 2011-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011151618A2 WO2011151618A2 (en) | 2011-12-08 |
WO2011151618A3 true WO2011151618A3 (en) | 2012-03-08 |
Family
ID=44947122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2011/000828 WO2011151618A2 (en) | 2010-06-01 | 2011-06-01 | Compounds for the treatment of clostridium difficile-associated disease |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011151618A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103282034A (en) * | 2010-11-18 | 2013-09-04 | 利亘制药公司 | Use of hematopoietic growth factor mimetics |
KR101585288B1 (en) | 2012-05-31 | 2016-01-14 | 주식회사 엘지화학 | Aromatic compound and organic solar cell comprising the same |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
US11168062B2 (en) | 2016-09-12 | 2021-11-09 | University Of Notre Dame Du Lac | Compounds for the treatment of Clostridium difficile infection |
BR112022000484A2 (en) * | 2019-07-17 | 2022-03-08 | Summit Oxford Ltd | Ridinylazole preparation process and crystalline forms thereof |
KR102296290B1 (en) * | 2020-12-31 | 2021-09-01 | 주식회사 바이오뱅크힐링 | Bifidobacterium adolescentis strain, and vesicles from thereof and anti-inflammation and anti-bacteria uses of thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006076009A2 (en) * | 2004-04-23 | 2006-07-20 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
WO2011046954A1 (en) * | 2009-10-13 | 2011-04-21 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3696495A (en) | 1994-11-17 | 1996-06-17 | F. Hoffmann-La Roche Ag | Antibacterial dibenzimidazole derivatives |
AP2003002824A0 (en) | 2000-12-15 | 2003-09-30 | Vertex Pharma | Gyrase inhibitors and uses thereof |
KR101052433B1 (en) | 2002-06-13 | 2011-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 2-ureido-6-heteroaryl-3H-benzoimidazole-4-carboxylic acid derivatives as gyrase and / or topoisomerase IV inhibitors and pharmaceutical compositions for treating bacterial infections comprising the same |
WO2004041209A2 (en) | 2002-11-01 | 2004-05-21 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
AU2006345003A1 (en) | 2005-08-12 | 2008-04-10 | United States Government As Represented By The Secretary Of The United States Army And The U.S. Army Medical Research & Materiel Command | Broad spectrum antibacterial compounds |
CA2626685A1 (en) | 2005-11-07 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Benzimidazole derivatives as gyrase inhibitors |
GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
-
2011
- 2011-06-01 WO PCT/GB2011/000828 patent/WO2011151618A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006076009A2 (en) * | 2004-04-23 | 2006-07-20 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
WO2011046954A1 (en) * | 2009-10-13 | 2011-04-21 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
Non-Patent Citations (4)
Title |
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AKASHI, HIROYOSHI: "Reactions and applications of itaconic acid. XV. Synthesis of heat resistant polymers from the reaction products between itaconic acid and two aromatic diamines", MEMOIRS OF THE FACULTY OF ENGINEERING, KOBE UNIVERSITY , NO. 16, 162-74 CODEN: MFEKAF; ISSN: 0368-9638, 1970 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1970, AKASHI, HIROYOSHI: "Reactions and applications of itaconic acid. XV. Synthesis of heat resistant polymers from the reaction products between itaconic acid and two aromatic diamines", XP002666796, retrieved from STN Database accession no. 1970:415332 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1972, YOKOTA, RIKIO ET AL: "Evaluation of the thermal stability of high polymers by thermogravimetry. Poly(benzimidazole) and its model compounds", XP002666795, retrieved from STN Database accession no. 1972:540641 * |
YOKOTA, RIKIO ET AL: "Evaluation of the thermal stability of high polymers by thermogravimetry. Poly(benzimidazole) and its model compounds", KOBUNSHI KAGAKU , 29(6), 428-31 CODEN: KOKAAM; ISSN: 0023-2556, 1972 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011151618A2 (en) | 2011-12-08 |
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