WO2011148312A3 - Improvements relating to the control of ions - Google Patents

Improvements relating to the control of ions Download PDF

Info

Publication number
WO2011148312A3
WO2011148312A3 PCT/IB2011/052244 IB2011052244W WO2011148312A3 WO 2011148312 A3 WO2011148312 A3 WO 2011148312A3 IB 2011052244 W IB2011052244 W IB 2011052244W WO 2011148312 A3 WO2011148312 A3 WO 2011148312A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
ions
electrical potential
lens
mass
Prior art date
Application number
PCT/IB2011/052244
Other languages
French (fr)
Other versions
WO2011148312A2 (en
Inventor
Emmanuel Raptakis
Dimitris Papanastasiou
Original Assignee
Fasmatech Science And Technology Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasmatech Science And Technology Sa filed Critical Fasmatech Science And Technology Sa
Priority to US13/699,721 priority Critical patent/US9190255B2/en
Priority to EP11735541.2A priority patent/EP2577710B1/en
Publication of WO2011148312A2 publication Critical patent/WO2011148312A2/en
Publication of WO2011148312A3 publication Critical patent/WO2011148312A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/067—Ion lenses, apertures, skimmers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/4245—Electrostatic ion traps
    • H01J49/425—Electrostatic ion traps with a logarithmic radial electric potential, e.g. orbitraps
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
PCT/IB2011/052244 2010-05-24 2011-05-23 Improvements relating to the control of ions WO2011148312A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/699,721 US9190255B2 (en) 2010-05-24 2011-05-23 Control of ions
EP11735541.2A EP2577710B1 (en) 2010-05-24 2011-05-23 Improvements relating to the control of ions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1008609.8 2010-05-24
GB1008609A GB2476844B (en) 2010-05-24 2010-05-24 Improvements relating to the control of ions

Publications (2)

Publication Number Publication Date
WO2011148312A2 WO2011148312A2 (en) 2011-12-01
WO2011148312A3 true WO2011148312A3 (en) 2012-02-16

Family

ID=42341202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/052244 WO2011148312A2 (en) 2010-05-24 2011-05-23 Improvements relating to the control of ions

Country Status (4)

Country Link
US (1) US9190255B2 (en)
EP (1) EP2577710B1 (en)
GB (1) GB2476844B (en)
WO (1) WO2011148312A2 (en)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
CA2670871C (en) * 2006-12-08 2016-02-02 Micromass Uk Limited Mass spectrometer
US9673034B2 (en) 2006-12-08 2017-06-06 Micromass Uk Limited Mass spectrometer
CN102751163B (en) * 2012-07-02 2015-07-15 西北核技术研究所 Device and method for improving abundance sensitivity of magnetic mass spectrum
DE112014001280T5 (en) * 2013-03-14 2015-12-03 Leco Corporation Method and system for tandem mass spectrometry
US9490115B2 (en) * 2014-12-18 2016-11-08 Thermo Finnigan Llc Varying frequency during a quadrupole scan for improved resolution and mass range
DE102014115034B4 (en) * 2014-10-16 2017-06-08 Bruker Daltonik Gmbh Time-of-flight mass spectrometer with spatial focusing of a broad mass range
US9847218B2 (en) * 2015-11-05 2017-12-19 Thermo Finnigan Llc High-resolution ion trap mass spectrometer
GB2563604B (en) 2017-06-20 2021-03-10 Thermo Fisher Scient Bremen Gmbh Mass spectrometer and method for time-of-flight mass spectrometry
GB2583758B (en) * 2019-05-10 2021-09-15 Thermo Fisher Scient Bremen Gmbh Improved injection of ions into an ion storage device
US11049713B1 (en) * 2020-05-12 2021-06-29 Honeywell International Inc. Deterministic reshaping and/or reordering of groups of atomic objects within an atomic object confinement apparatus
GB2595226B (en) * 2020-05-18 2024-10-16 Ascend Diagnostics Ltd Mass spectrometer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040232327A1 (en) * 2003-03-11 2004-11-25 Bateman Robert Harold Mass spectrometer
US20090014647A1 (en) * 2007-07-13 2009-01-15 Senko Michael W Correction of Time of Flight Separation in Hybrid Mass Spectrometers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506695D0 (en) 1995-03-31 1995-05-24 Hd Technologies Limited Improvements in or relating to a mass spectrometer
DE19635643C2 (en) 1996-09-03 2001-03-15 Bruker Daltonik Gmbh Spectra acquisition method and linear time-of-flight mass spectrometer therefor
DE19638577C1 (en) 1996-09-20 1998-01-15 Bruker Franzen Analytik Gmbh Simultaneous focussing of all masses in time of flight mass spectrometer
US5747801A (en) * 1997-01-24 1998-05-05 University Of Florida Method and device for improved trapping efficiency of injected ions for quadrupole ion traps
US6130426A (en) 1998-02-27 2000-10-10 Bruker Daltonics, Inc. Kinetic energy focusing for pulsed ion desorption mass spectrometry
US6518568B1 (en) 1999-06-11 2003-02-11 Johns Hopkins University Method and apparatus of mass-correlated pulsed extraction for a time-of-flight mass spectrometer
GB2404784B (en) * 2001-03-23 2005-06-22 Thermo Finnigan Llc Mass spectrometry method and apparatus
GB0107380D0 (en) * 2001-03-23 2001-05-16 Thermo Masslab Ltd Mass spectrometry method and apparatus
US7385187B2 (en) * 2003-06-21 2008-06-10 Leco Corporation Multi-reflecting time-of-flight mass spectrometer and method of use
US20050253059A1 (en) * 2004-05-13 2005-11-17 Goeringer Douglas E Tandem-in-time and-in-space mass spectrometer and associated method for tandem mass spectrometry
GB0424426D0 (en) * 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB0526245D0 (en) * 2005-12-22 2006-02-01 Shimadzu Res Lab Europe Ltd A mass spectrometer using a dynamic pressure ion source
GB0624740D0 (en) * 2006-12-12 2007-01-17 Micromass Ltd Mass spectrometer
US7932491B2 (en) * 2009-02-04 2011-04-26 Virgin Instruments Corporation Quantitative measurement of isotope ratios by time-of-flight mass spectrometry
GB201110662D0 (en) * 2011-06-23 2011-08-10 Thermo Fisher Scient Bremen Targeted analysis for tandem mass spectrometry

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040232327A1 (en) * 2003-03-11 2004-11-25 Bateman Robert Harold Mass spectrometer
US20090014647A1 (en) * 2007-07-13 2009-01-15 Senko Michael W Correction of Time of Flight Separation in Hybrid Mass Spectrometers

Also Published As

Publication number Publication date
US9190255B2 (en) 2015-11-17
EP2577710B1 (en) 2016-11-02
GB201008609D0 (en) 2010-07-07
GB2476844A (en) 2011-07-13
WO2011148312A2 (en) 2011-12-01
US20130068944A1 (en) 2013-03-21
EP2577710A2 (en) 2013-04-10
GB2476844B (en) 2011-12-07

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