WO2008102155A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
WO2008102155A3
WO2008102155A3 PCT/GB2008/000617 GB2008000617W WO2008102155A3 WO 2008102155 A3 WO2008102155 A3 WO 2008102155A3 GB 2008000617 W GB2008000617 W GB 2008000617W WO 2008102155 A3 WO2008102155 A3 WO 2008102155A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion trap
mass spectrometer
radially
ejected
slot
Prior art date
Application number
PCT/GB2008/000617
Other languages
French (fr)
Other versions
WO2008102155A2 (en
Inventor
Robert Harold Bateman
Martin Green
Jason Lee Wildgoose
Original Assignee
Micromass Ltd
Robert Harold Bateman
Martin Green
Jason Lee Wildgoose
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass Ltd, Robert Harold Bateman, Martin Green, Jason Lee Wildgoose filed Critical Micromass Ltd
Priority to EP08709499.1A priority Critical patent/EP2113129B1/en
Priority to US12/528,173 priority patent/US8519331B2/en
Publication of WO2008102155A2 publication Critical patent/WO2008102155A2/en
Publication of WO2008102155A3 publication Critical patent/WO2008102155A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0095—Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/423—Two-dimensional RF ion traps with radial ejection
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods 1 to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
PCT/GB2008/000617 2007-02-21 2008-02-21 Mass spectrometer WO2008102155A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08709499.1A EP2113129B1 (en) 2007-02-21 2008-02-21 Mass spectrometer
US12/528,173 US8519331B2 (en) 2007-02-21 2008-02-21 Mass spectrometer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0703378.0A GB0703378D0 (en) 2007-02-21 2007-02-21 Mass spectrometer
GB0703378.0 2007-02-21
US89521207P 2007-03-16 2007-03-16
US60/895,212 2007-03-16

Publications (2)

Publication Number Publication Date
WO2008102155A2 WO2008102155A2 (en) 2008-08-28
WO2008102155A3 true WO2008102155A3 (en) 2009-06-25

Family

ID=37909024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000617 WO2008102155A2 (en) 2007-02-21 2008-02-21 Mass spectrometer

Country Status (4)

Country Link
US (1) US8519331B2 (en)
EP (1) EP2113129B1 (en)
GB (2) GB0703378D0 (en)
WO (1) WO2008102155A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007034232B4 (en) 2007-07-23 2012-03-01 Bruker Daltonik Gmbh Three-dimensional high frequency ion traps high trapping efficiency
DE102008023694B4 (en) * 2008-05-15 2010-12-30 Bruker Daltonik Gmbh Fragmentation of analyte ions by ion impact in RF ion traps
US7947948B2 (en) * 2008-09-05 2011-05-24 Thermo Funnigan LLC Two-dimensional radial-ejection ion trap operable as a quadrupole mass filter
GB0817115D0 (en) * 2008-09-18 2008-10-29 Micromass Ltd Mass spectrometer
GB0909292D0 (en) * 2009-05-29 2009-07-15 Micromass Ltd Ion tunnelion guide
FR2950697B1 (en) * 2009-09-25 2011-12-09 Biomerieux Sa METHOD FOR DETECTING MOLECULES BY MASS SPECTROMETRY
RU2466475C2 (en) * 2010-02-11 2012-11-10 Симадзу Корпорейшн Electrode system of linear ion trap
DE102010022184B4 (en) * 2010-05-21 2013-04-04 Bruker Daltonik Gmbh Mixed frequency rod system as ion reactor
GB201120307D0 (en) 2011-11-24 2012-01-04 Thermo Fisher Scient Bremen High duty cycle mass spectrometer
WO2014144667A2 (en) * 2013-03-15 2014-09-18 1St Detect Corporation Ion trap with radial opening in ring electrode
US9281173B2 (en) * 2013-05-30 2016-03-08 Agilent Technologies, Inc. Ion processing utilizing segmented vacuum manifold
CN205984893U (en) 2013-05-30 2017-02-22 珀金埃尔默健康科学股份有限公司 Reflector, lens reach external member including lens
WO2014197348A2 (en) * 2013-06-03 2014-12-11 Perkinelmer Health Sciences, Inc. Ion guide or filters with selected gas conductance
EP3087581A4 (en) * 2013-12-23 2017-07-26 DH Technologies Development PTE. Ltd. Mass spectrometer
US9905407B2 (en) * 2014-10-02 2018-02-27 908 Devices Inc. Mass spectrometry by detecting positively and negatively charged particles
GB201509243D0 (en) * 2015-05-29 2015-07-15 Micromass Ltd Mass filter having extended operational lifetime
GB201608476D0 (en) 2016-05-13 2016-06-29 Micromass Ltd Ion guide
CN108538702B (en) * 2018-05-29 2019-10-11 清华大学深圳研究生院 The method for carrying out negative ions analysis simultaneously in an ion trap
CN113325062A (en) * 2021-04-28 2021-08-31 中国计量科学研究院 Scanning device and scanning method based on ion trap
WO2024123515A2 (en) * 2022-12-07 2024-06-13 Teledyne Flir Detection, Inc. A mass spectrometer and a method for analyzing a sample therein
US20240222106A1 (en) * 2022-12-29 2024-07-04 Thermo Finnigan Llc Apparatus and Method for Ion Separation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014259A1 (en) * 1991-02-12 1992-08-20 Kirchner Nicholas J Ion processing: storage, cooling and spectrometry
US5576540A (en) * 1995-08-11 1996-11-19 Mds Health Group Limited Mass spectrometer with radial ejection
WO2004017358A1 (en) * 2002-08-19 2004-02-26 Mds Inc. , D.B.A. Mds Sciex Quadrupole mass spectrometer with spatial dispersion
WO2004063702A2 (en) * 2003-01-10 2004-07-29 Purdue Research Foundation Rectilinear ion trap and mass analyzer system and method
US20040149903A1 (en) * 2003-01-31 2004-08-05 Yang Wang Ion trap mass spectrometry

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5625186A (en) * 1996-03-21 1997-04-29 Purdue Research Foundation Non-destructive ion trap mass spectrometer and method
JP2003507874A (en) 1999-08-26 2003-02-25 ユニバーシティ オブ ニュー ハンプシャー Multi-stage mass spectrometer
US6844547B2 (en) * 2002-02-04 2005-01-18 Thermo Finnigan Llc Circuit for applying supplementary voltages to RF multipole devices
US6797950B2 (en) * 2002-02-04 2004-09-28 Thermo Finnegan Llc Two-dimensional quadrupole ion trap operated as a mass spectrometer
WO2007112549A1 (en) 2006-04-03 2007-10-11 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Method and apparatus for providing ion barriers at the entrance and exit ends of a mass spectrometer
US7456389B2 (en) 2006-07-11 2008-11-25 Thermo Finnigan Llc High throughput quadrupolar ion trap

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014259A1 (en) * 1991-02-12 1992-08-20 Kirchner Nicholas J Ion processing: storage, cooling and spectrometry
US5576540A (en) * 1995-08-11 1996-11-19 Mds Health Group Limited Mass spectrometer with radial ejection
WO2004017358A1 (en) * 2002-08-19 2004-02-26 Mds Inc. , D.B.A. Mds Sciex Quadrupole mass spectrometer with spatial dispersion
WO2004063702A2 (en) * 2003-01-10 2004-07-29 Purdue Research Foundation Rectilinear ion trap and mass analyzer system and method
US20040149903A1 (en) * 2003-01-31 2004-08-05 Yang Wang Ion trap mass spectrometry

Also Published As

Publication number Publication date
EP2113129B1 (en) 2015-04-29
GB2447325A (en) 2008-09-10
GB2447325B (en) 2010-03-10
EP2113129A2 (en) 2009-11-04
US20110057097A1 (en) 2011-03-10
WO2008102155A2 (en) 2008-08-28
US8519331B2 (en) 2013-08-27
GB0703378D0 (en) 2007-03-28
GB0803193D0 (en) 2008-04-02

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