WO2011141822A3 - Methods for induction, predictive diagnosis, and treatment of affective behaviors by modulation of ppar and rxr receptors - Google Patents
Methods for induction, predictive diagnosis, and treatment of affective behaviors by modulation of ppar and rxr receptors Download PDFInfo
- Publication number
- WO2011141822A3 WO2011141822A3 PCT/IB2011/001447 IB2011001447W WO2011141822A3 WO 2011141822 A3 WO2011141822 A3 WO 2011141822A3 IB 2011001447 W IB2011001447 W IB 2011001447W WO 2011141822 A3 WO2011141822 A3 WO 2011141822A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- ppar
- induction
- modulation
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 101150014691 PPARA gene Proteins 0.000 title 1
- 230000006399 behavior Effects 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 2
- 102000034527 Retinoid X Receptors Human genes 0.000 abstract 2
- 108010038912 Retinoid X Receptors Proteins 0.000 abstract 2
- 230000002411 adverse Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 150000004492 retinoid derivatives Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/30—Psychoses; Psychiatry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention is directed to methods for modulating or detecting changes in peroxisome proliferator activated receptors (PPARs) and retinoid X receptors (RXR) to: 1) treat certain neuropsychiatric disorders, 2) identify susceptibility to such disorders in a clinical setting, and 3) screen novel pharmacological agents, including retinoids and retinoid derivatives for adverse psychiatric side-effects, and 4) generate certain neuropsychiatric disorders in preclinical conditions.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33372710P | 2010-05-11 | 2010-05-11 | |
US33372510P | 2010-05-11 | 2010-05-11 | |
US61/333,727 | 2010-05-11 | ||
US61/333,725 | 2010-05-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011141822A2 WO2011141822A2 (en) | 2011-11-17 |
WO2011141822A3 true WO2011141822A3 (en) | 2012-03-29 |
Family
ID=44630266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2011/001447 WO2011141822A2 (en) | 2010-05-11 | 2011-05-11 | Methods for induction, predictive diagnosis, and treatment of affective behaviors by modulation of ppar and rxr receptors |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011141822A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8475775B1 (en) * | 2012-08-24 | 2013-07-02 | The Uab Research Foundation | Retinoids and use thereof |
EP3649950A4 (en) * | 2017-07-07 | 2020-06-03 | Panasonic Intellectual Property Management Co., Ltd. | Information provision method, information processing system, information terminal, and information processing method |
EP3650858A4 (en) * | 2017-07-07 | 2020-05-27 | Panasonic Intellectual Property Management Co., Ltd. | Information provision method, information processing system, information terminal, and information processing method |
CN110546501B (en) * | 2017-07-07 | 2022-01-11 | 松下知识产权经营株式会社 | Information providing method, information processing system, information terminal, and information processing method |
CN110612445B (en) * | 2017-07-07 | 2022-07-08 | 松下知识产权经营株式会社 | Information providing method, information processing system, information terminal, and information processing method |
CN110537097B (en) * | 2017-07-07 | 2022-03-08 | 松下知识产权经营株式会社 | Information providing method, information processing system, information terminal, and information processing method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
DE102005020229A1 (en) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Use of indoline-phenylsulfonamide derivatives |
JP2008247829A (en) * | 2007-03-30 | 2008-10-16 | National Institute Of Advanced Industrial & Technology | Therapeutic agent for rhythm trouble containing ligand of intranuclear receptor |
WO2010068750A2 (en) * | 2008-12-11 | 2010-06-17 | Board Of Trustees Of Leland Stanford Junior University | Compositons and method for treatment of mood and cognitive impairments |
-
2011
- 2011-05-11 WO PCT/IB2011/001447 patent/WO2011141822A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
DE102005020229A1 (en) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Use of indoline-phenylsulfonamide derivatives |
JP2008247829A (en) * | 2007-03-30 | 2008-10-16 | National Institute Of Advanced Industrial & Technology | Therapeutic agent for rhythm trouble containing ligand of intranuclear receptor |
WO2010068750A2 (en) * | 2008-12-11 | 2010-06-17 | Board Of Trustees Of Leland Stanford Junior University | Compositons and method for treatment of mood and cognitive impairments |
Non-Patent Citations (2)
Title |
---|
LOGAN ALAN C: "Omega-3 fatty acids and major depression: A primer for the mental health professional", LIPIDS IN HEALTH AND DISEASE, BIOMED CENTRAL, LONDON, GB, vol. 3, no. 1, 9 November 2004 (2004-11-09), pages 25, XP021008308, ISSN: 1476-511X, DOI: 10.1186/1476-511X-3-25 * |
VAN NEERVEN S ET AL: "RAR/RXR and PPAR/RXR signaling in neurological and psychiatric diseases", PROGRESS IN NEUROBIOLOGY, PERGAMON PRESS, GB, vol. 85, no. 4, 1 August 2008 (2008-08-01), pages 433 - 451, XP023521896, ISSN: 0301-0082, [retrieved on 20080504], DOI: 10.1016/J.PNEUROBIO.2008.04.006 * |
Also Published As
Publication number | Publication date |
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WO2011141822A2 (en) | 2011-11-17 |
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